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sequence
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2.75k
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5.51k
AlphaFoldDB
stringlengths
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10
A5CR32
OBG_CLAM3
GTP-binding protein Obg
Clavibacter
MATFVDTVTLHLRAGNGGNGCVSVRREKFKPLAGPDGGNGGNGGDIVLVADPQVTTLLAYHRGPHRSSRNGGPGMGDHRHGTLGEALELHVPVGTVVKDADGNELADMATPGMRFIAAEAGQGGLGNASLATTKRKAPGFALLGTRGYEGDVVLELKVVADVALVGYPSAGKSSLVAAISAAKPKIADYPFTTLHPNLGVVEVADSRYTVADVPGLIEGASEGKGLGLEFLRHVERCSALLHVLDCATLDPGRDPISDLDIILTELAAYPVPDGQVPLLDRPQLIALNKIDVPEARELAELVRPELEARGYRVFDISTVSHDGLRQLSFALAELVEDARTKAAEEPEAPRIVLRPRAVNEKPFTIRVDGGSYGDIYRVIGTKPERWVQQTDFTNDEAVGYLADRLAKLGVEDGLFKAGAVAGSSVVIGEGDGIVFDWEPTLTSTAELITSPRGADARVDPISRRTNQARREDYFARMDAKAEARAQLVREGEAGLWADEDGTDEDASSDAKA
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
A5CR32
O54457
PPSA_ENTAG
Pyruvate, water dikinase
Pantoea agglomerans group
MSSKGEQPLVLWYNQLGMHDVDRVGGKNPSLGEMITNLSSLGVSVPNGFATTSYAFNLFLD
Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.
O54457
Q0TC49
MALT_ECOL5
ATP-dependent transcriptional activator MalT
Escherichia
MLIPSKLSRPVRLDHTVVRERLLAKLSGANNFRLALITSPAGYGKTTLISQWAAGKNDIGWYSLDEGDNQQERFASYLIAAVQQATNGHCAICETMAQKRQYASLTSLFAQLFIELAEWHSPLYLVIDDYHLITNPVIHESMRFFIRHQPENLTLVVLSRNLPQLGIANLRVRDQLLEIGSQQLAFTHQEAKQFFDCRLSSPIEAAESSRICDDVSGWATALQLIALSARQNTHSAHKSARRLAGINASHLSDYLVDEVLDNVDLATRHFLLKSAILRSMNDALITRVTGEENGQMRLEEIERQGLFLQRMDDTGEWFCYHPLFGNFLRQRCQWELAAELPEIHRAAAESWMAQGFPSEAIHHALAAGDALMLRDILLNHAWSLFNHSELSLLEESLKALPWDSLLENPQLVLLQAWLMQSQHRYGEVNTLLARAEHEIKDIREGTMHAEFNALRAQVAINDGSPDEAERLAKLALEELPPGWFYSRIVATSVLGEVLHCKGELTRSLALMQQTEQMARQHDVWHYALWSLIQQSEILFAQGFLQTAWETQEKAFQLINEQHLEQLPMHEFLVRIRAQLLWAWARLDEAEASARSGIEVLSSYQPQQQLQCLAMLIQCSLARGDLDNARSQLNRLENLLGNGKYHSDWISNANKVRVIYWQMTGDKAAAANWLRHTAKPEFANNHFLQGQWRNIARAQILLGEFESAEIVLEELNENARSLRLMSDLNRNLLLLNQLYWQAGRKSDAQRVLLDALKLANRTGFISHFVIEGEAMAQQLRQLIQLNTLPELEQHRAQRILREINQHHRHKFAHFDENFVERLLNHPEVPELIRTSPLTQREWQVLGLIYSGYSNEQIAGELEVAATTIKTHIRNLYQKLGVAHRQAAVQHAQKLLKMMGYGV
Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides. Specifically binds to the promoter region of its target genes, recognizing a short DNA motif called the MalT box.
Q0TC49
P31415
CASQ1_HUMAN
Calsequestrin, skeletal muscle isoform
Homo
MSATDRMGPRAVPGLRLALLLLLVLGTPKSGVQGQEGLDFPEYDGVDRVINVNAKNYKNVFKKYEVLALLYHEPPEDDKASQRQFEMEELILELAAQVLEDKGVGFGLVDSEKDAAVAKKLGLTEVDSMYVFKGDEVIEYDGEFSADTIVEFLLDVLEDPVELIEGERELQAFENIEDEIKLIGYFKSKDSEHYKAFEDAAEEFHPYIPFFATFDSKVAKKLTLKLNEIDFYEAFMEEPVTIPDKPNSEEEIVNFVEEHRRSTLRKLKPESMYETWEDDMDGIHIVAFAEEADPDGFEFLETLKAVAQDNTENPDLSIIWIDPDDFPLLVPYWEKTFDIDLSAPQIGVVNVTDADSVWMEMDDEEDLPSAEELEDWLEDVLEGEINTEDDDDDDDD
Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle . Calcium ions are bound by clusters of acidic residues at the protein surface, often at the interface between subunits. Can bind around 80 Ca(2+) ions . Regulates the release of lumenal Ca(2+) via the calcium release channel RYR1; this plays an important role in triggering muscle contraction. Negatively regulates store-operated Ca(2+) entry (SOCE) activity .
P31415
Q8A749
NTPPA_BACTN
Nucleotide pyrophosphatase
Bacteroides
MLGNLDKYQIILASNSPRRKELMSGLGVDYVVRTLPDVDESYPADLAGAEIPEYISREKADAYRSIMQPGELLITADTIVWLDGKVLGKPEGREGAVEMLRSLSGKSHQVFTGVCLTTTEWQKSFTAASDVEFDVLSEEEIRYYVDKYQPMDKAGAYGVQEWIGYIGVKSISGSFYNIMGLPIQKLYGELKKL
Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
Q8A749
Q3ZBJ8
MFRN1_BOVIN
Solute carrier family 25 member 37
Bos
MELRRGGVGSQARARRMDGDSRDGGGGCKDAGSEDYENLPTSASLSTHMTAGAMAGILEHSVMYPVDSVKTRMQSLNPDPKAHYTSVYGALKKIIRTEGFWRPLRGLNVMMMGAGPAHAMYFACYENMKRTLNAVFHHQGNSHLANGICKRLSGVRKVSPSTDPSPGFSSL
Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis.
Q3ZBJ8
Q9LXZ8
TRH10_ARATH
Putative thioredoxin H10
Arabidopsis
MGNRCARTSCCRKLWSCICCCSNNNNNSYGQTRSQHGSKGKVHPVSRIEKWEEKITEANNHGKILVVNFSAPWCVPCKKIEPVFRDLASRYPSMIFVTVDVEELAEFSNEWNVEATPTVVFLKDGRQMDKLVGAETSELQKKTAAAADLFLRKP
Probable thiol-disulfide oxidoreductase that may be involved in the redox regulation of a number of cytosolic enzymes.
Q9LXZ8
O57774
DTDA_PYRHO
D-tyrosyl-tRNA(Tyr) deacylase
Pyrococcus
MKVIMTTKVDKASMNIMNKLIENFGFKETEYVFDGNPVYKRGDVLILTTNDEMIYYDYLDREIENQLGFKPEIIAFASRHSSKQKLPALTTHVTGNWGKAMYGGKDESFAVAIPSAMKLSLLKMSELNDLGWTVCYEATHHGPTELEVPSFFIEIGSSEEEWINDRAGEIIAETIIYVLDNYEKGRSKFKVALGIGGGHYAPKQTKRALEGDLAFGHILPKYAQPVSRDVMIKALNRFGEKVEAIYVDWKGSRGETRQLAKSLAQELGLEFIKD
D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.
O57774
Q6D1T5
LUXS_PECAS
Autoinducer-2 production protein LuxS
Pectobacterium
MPLLDSFTVDHTRMAAPAVRVAKTMKTPHGDNITVFDLRFCRPNIEVMPERGIHTLEHLFAGFMRDHLNGDGVEIIDISPMGCRTGFYMSLIGTPDEQRVAESWKAAMSDVLKVTDQRKIPELNEYQCGTYDMHSLKEAQEIAQHIVDHDIGINQNDDLALPKDKLAELHI
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).
Q6D1T5
G9FRD7
HDHA_CLOSR
NADP-dependent 7alpha-hydroxysteroid dehydrogenase
Clostridium
MKRLEGKVAIVTSSTRGIGRASAEALAKEGALVYLAARSEELANEVIADIKKQGGVAKFVYFNAREEETYTSMVEKVAEAEGRIDILVNNYGGTNVNLDKNLTAGDTDEFFRILKDNVQSVYLPAKAAIPHMEKVGGGSIVNISTIGSVVPDISRIAYCVSKSAINSLTQNIALQYARKNIRCNAVLPGLIGTRAALENMTDEFRDSFLGHVPLNRVGRPEDIANAVLYYASDDSGYVTGMIHEVAGGFALGTPQYSEYCPR
7alpha-hydroxysteroid dehydrogenase that catalyzes the NADP(+)-dependent oxidation of the 7alpha-hydroxy group of 7alpha-hydroxysteroids, such as cholate, chenodeoxycholate, glycochenodeoxycholate and taurochenodeoxycholate, to the corresponding 7-oxosteroids . Is also able to catalyze the reverse reduction reactions . Together with 7beta-HSDH encoded in the adjacent gene, is likely involved in the epimerization of the hydroxy group at C-7 of primary bile acids through 7-keto bile acid intermediates .
G9FRD7
Q4K629
PANB1_PSEF5
Ketopantoate hydroxymethyltransferase 1
Pseudomonas
MSSHTRTQRLSVPQLVAMKGRQKIVSLTAYTSHMARLMDPFVDFILIGDSTAMVGYGRTSTLDMSLAEIIAHTRAVVAGSRLACVIADMPFGSYQESPQQAYRNCAEVMARTGCAALKLEGGRALAPTVEFLVQRGIPVMAHIGLMPQFVNQMGGFKAQGLDSEAARKIEEDARAHLEAGAFSLLLEGVAEPLARRISDFSPMPTIGIGASPACDGQVLVTEDLLGLGGPQVPRFVKQYADAGALISQACERFAAEVREQAFPQLQHCYGVVQEA
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
Q4K629
B1Y500
BIOF_LEPCP
8-amino-7-ketopelargonate synthase
Leptothrix
MLIEHLNRQLREREAQSLRRRRRIAETPCAPHQRVSLDGQTASEARELLAFCSNDYLGLANHPALIGALAEGARLWGAGAGASHLISGHTRAHAALEDTLAEWAAPNIPGAKALSFCTGYMANLALLTALGDAEATLFADKLNHASLVDGALLAKAKLQRYAHRQFDVLERQLAACTTPIKLIVTDAVFSMDGDLAELDQLLSLAERFDAWLVIDDAHGFGVLGPKGRGSLAHFGLRSERLILMGTLGKAAGLGGAFVAAHPSVIDWLVQSARAYIYTTAAPPAIAHALSASLALIAGDEGEARRQHLRELIAALRCQLAALIAAQPQLGWRLAESDTAIQPLIVGSNDSALALAAALDAQGLWVPAIRPPTVPVGTARLRITLSAAHSQADVTRLVAALATTARELA
Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
B1Y500
Q8BWQ4
CMTR2_MOUSE
FtsJ methyltransferase domain-containing protein 1
Mus
MSKRRKLPARQPACLETFSPDVLNDVSELFAKSFSYRKPLDNEWQLPAPTESFSCGHLEFRALLDLKNSLNEVKNLLSDKKLDEWHRHTAFTNKAGKIISHVKKAVNAELCTQAWCKFQEILCSFPLIPQEAFQSGRLNSLHLCEAPGAFIASLNHYLKSHRFPCEWSWVANSLNPYHEANDNLRMITDDRLMANTLHCWYFGPDNTGDIMTLKYLTGLQDFLSGMSPIHLVTADGSFDCQGNPGEQEALVSSLHYCEAVTALITLGDGGSFVLKMFTLFEHCSVNLMYLLNCSFDQVHVFKPATSKAGNSEVYVVCLRYKGREAVQPLLSRMVLNFGTEMTRKALFPHHVIPKSFLERHEECCTFFHRYQLETISENIRLFESMGTGEQERLNNLRDCAVQYFMQKFQLKPLSRNHWLVKKSNIGCSMNTKWFGQRNKYFKTYNERKMMETLSWKDKVAKGYFNSWAEEHTVYHPGQNSLLEGTASSLEYQSWQVLEGKKLPKVKCSPFCDGEILKTLNEAIEKSLGEALSVDAKVSSKQQYRCCPVFSEESVLSELLRLTKCLPDEQGAEPSGPVKCLLVGSPAVCDLQMPAPLEIQLVESVELTAFSCSLLHDGDPAYQHLFLDCLLHSLRRLHRGDVMVLPILSCFTRFMAGLTFVLHGCFRFITFSCPTSLEPLRTCAVLLCIGYQNLPDAVFQFLQNVHDLLSKLLHPSAPRQILQFLPMEALLQGTLLDFLWDLNAAIAKRHLHLIIQGERDQAIGSLEL
S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap2 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the second nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) (cap0) to produce m(7)GpppRmpNm (cap2). Recognizes a guanosine cap on RNA independently of its N(7) methylation status. Display cap2 methylation on both cap0 and cap1. Displays a preference for cap1 RNAs.
Q8BWQ4
P01848
TRAC_HUMAN
T cell receptor alpha chain constant
Homo
IQNPDPAVYQLRDSKSSDKSVCLFTDFDSQTNVSQSKDSDVYITDKTVLDMRSMDFKSNSAVAWSNKSDFACANAFNNSIIPEDTFFPSPESSCDVKLVEKSFETDTNLNFQNLSVIGFRILLLKVAGFNLLMTLRLWSS
Constant region of T cell receptor (TR) alpha chain . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens . Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation . The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity .
P01848
B3TN47
ATPF_BRADI
ATPase subunit I
Brachypodium
MKNVTHSFVFLAHWPSAGSFGLNTDILATNLINLTVVVGVLIFFGKGVLKDLLDNRKQRILSTIRNSEELRRGTFEQLEKARIRLQKVELEADEYRMNGYSEIEREKENLINATSISLEQLEKSKNETLYFEKQRAMNQVRQRVFQQAVQGALGTLNSCLNTELHFRTIRANIGILGSMEWKR
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
B3TN47
P35861
CH602_BRADU
Chaperonin-60 2
Bradyrhizobium
MSAKEVKFGVDARDRMLRGVDILHNAVKVTLGPKGRNVVLDKSFGAPRITKDGVTVAKEIELEDKFENMGAQMVREVASKSADAAGDGTTTATVLAAAIVREGAKSVAAGMNPMDLKRGIDMAVEAVVADLVKNSKKVTSNEEIAQVGTISANGDAEIGKFISDAMKKVGNEGVITVEEAKSLETELEVVEGMQFDRGYISPYFVTNADKMRVEMDDAYVLINEKKLSQLNELLPLLEAVVQSGKPLVIIAEDVEGEALATLVVNRLRGGLKVAAVKAPGFGDRRKAMLQDIAILTGGQAISEDLGIKLENVTLNMLGRAKKVMIDKENTTIVSGAGKKADIEARVAQIKAQIEETTSDYDREKLQERLAKLAGGVAVIRVGGATEVEVKERKDRVDDAMHATRAAVEEGILPGGGVALLRASEHLKGIRTKNDDQKTGVEIVRKALSYPARQIAINAGEDGSVIVGKILEKDQYSYGYDSQTGEYGNLVSKGIIDPTKVVRVAIQNAASVAALLITTEAMVAEVPKKNTGAGGMPPGGGGMGGMGGMDF
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
P35861
A1AHD0
SELA_ECOK1
Selenocysteinyl-tRNA(Sec) synthase
Escherichia
MTTETRSLYSQLPAIDRLLRDSSFLSLRDTYGHTRVVELLRQMLDEAREVIRDSQTLPAWCENWAQEVDARLTKEAQSALRPVINLTGTVLHTNLGRALQAEAAVEAVTKAMRSPVTLEYDLDDAGRGHRDRALAQLLCRITGAEDACIVNNNAAAVLLMLAATASGKEVVVSRGELVEIGGAFRIPDVMRQAGCTLHEVGTTNRTHANDYRQAVNENTALLMKVHTSNYSIQGFTKAIDEAELVALGKELDVPVVTDLGSGSLVDLSQYGLPKEPMPQELIAAGVSLVSFSGDKLLGGPQAGIIVGKKEMIARLQSHPLKRALRADKMTLAALEATLRLYLHPEALSEKLPTLRLLTRSAEVIQIQAQRLQAPLAAHYGAEFAVQVMPCLSQIGSGSLPVDRLPSAALTFTPHDGRGSHLESLAARWRELPVPVIGRIYDGRLWLDLRCLEDEQRFLEMLLK
Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
A1AHD0
Q039F7
TYSY_LACP3
Thymidylate synthase
Lacticaseibacillus
MLEQPYLDLAQKVLDEGHFKPDRTHTGTYSIFGHQMRFDLSKGFPLLTTKKVPFGLIKSELLWFLRGDTNIRFLLQHKNHIWDEWAFEKWVASPDYHGPDMTDFGHRSQKDPEFAASYREQMAKFDERILTDESFAAKYGDLGLVYGSQWRAWHTSRGDTIDQLGDVIEQIKTHPYSRRLIVSAWNPEDVPTMALPPCHTLFQFYVNDGKLSLQLYQRSADIFLGVPFNIASYALLTHLVAHECGLQVGDFIHTFGDAHLYVNHLDQIKEQLTRTPRQAPTLVLNPDKHDIFDFDMQDIKLLNYDPYPAIKAPVAV
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Q039F7
A1VUV0
BPHD_POLNA
2,6-dioxo-6-phenylhexa-3-enoate hydrolase
Polaromonas
MTALTESSTSKFVKINEKGFSDFQIHYNEAGNGETVIMLHGGGPGAGGWSNYYRNIGAFVEAGYRVILKDSPGFNKSDAVVMDEQRGLVNARAVKGLMDALDIDRAHLVGNSMGGATALNFALEYPDRIGKLILMGPGGLGPSMFAPMPMEGIKLLFKLYAEPSYETLKQMLQVFLYDQSLITEELLQGRWEAIQRNPEHLKNFLVSAQKAPLSTWDVSARLGEIKAKTFITWGRDDRFVPLDHGLKLVWGINDARLHVFSKCGHWAQWEHADEFNRLVIDFLRHA
Catalyzes an unusual C-C bond hydrolysis of 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid (HOPDA) to produce benzoic acid and 2-hydroxy-2,4-pentadienoic acid (HPD).
A1VUV0
B3PY58
NUOC2_RHIE6
NDH-1 subunit C 2
Rhizobium
MSVEPSLNRAPIMERFGDTIEDLGTAHGIDVFAVPPERIVEFCRFLKEHPAMQFNFLSDICGVDHYPETPRFEAVYHLYSLPNRWRVRIKCRLGDPPEVPSVTGVWRTANWHEREAWDMYGIRFAGHPDLRRIYMWEGFEGFPQRKDFPLRGYKDKLNPFGAEGPPPTQPDLATRDIPQGRPSTPES
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
B3PY58
E1VBK3
TEAC_HALED
Ectoine TRAP transporter large permease protein TeaC
Halomonas
MTTIMVATMIGLLLLGFPMMIPLATASIIGFFMMFGGLGQMETLIQQLMAGIRPASLIAVPMFILAADIMTRGQSANRLINMVMAFIGHIKGGLAVSTAASCTLFGAVSGSTQATVVAVGSPLRPRMLKAGYSDSFSLALIINSSDIAFLIPPSIGMIIYGIISGTSIGELFIAGIGPGLMILVMFAIYCVIYAIVRGVPTEPKASWGERFSAVRLALWPLGFPVIIIGGIYGGIFSPTEAAAACVLYAVLLEFVVFRSLKISDIYAIAKSTGLITAVVFILVAVGNSFSWIISFAQIPQAILEAVGINEAGPTGVLIAICVAFFVACMFVDPIVVILVLTPVFAPAIEATGLDPVLVGILITLQVAIGSATPPFGCDIFTAIAIFKRPYLDVIKGTPPFIFMLVLAAALLILFPQIALFLRDLAFR
Part of the tripartite ATP-independent periplasmic (TRAP) transport system TeaABC involved in the uptake of ectoine and hydroxyectoine in response to osmotic upshock. Probably functions as a recovery system for synthesized ectoine that leaks out of the cell.
E1VBK3
A6W5U9
RL24_KINRD
50S ribosomal protein L24
Kineococcus
MGKTRIKKGDLVQVITRVRGRRNADGTKTSDLGKQGKVLEVIAETDRVLVEGVNRIKRHTKARPGVEGGIVEREAPIHISNVQLVDPETKKPTRVGIRTEQVERDGRTKTNRIRVAKRSGKDI
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
A6W5U9
P15529
MCP_HUMAN
Trophoblast leukocyte common antigen
Homo
MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSSTKPPALSHSVSTSSTTKSPASSASGPRPTYKPPVSNYPGYPKPEEGILDSLDVWVIAVIVIAIVVGVAVICVVPYRYLQRRKKKGTYLTDETHREVKFTSL
(Microbial infection) May act as a receptor for pathogenic bacteria Neisseria and Streptococcus pyogenes .
P15529
Q253V7
DUT_CHLFF
dUTP pyrophosphatase
Chlamydia
MTIFCELESGVDLPEYATEGASGADLRANIEEPIAVLPGQRVLVPTGIKMQIPQGYEVQVRPRSGLALKHGIMVVNSPGTIDADYRGEVCIILANFGESTFIIEPKMRVAQAVVAPVVQAKFIVVDQEEGLTTTSRGSRGFGHTGEK
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
Q253V7
P44305
RIMI_HAEIN
[Ribosomal protein S18]-alanine N-acetyltransferase
Haemophilus
MSIISQIEACDFERLYEIEQQAHLVPWSFGTLKNNQGERYLNLKLIENNQIIGFAICQTVLDEATLFNIAILPTYQGCGFGKLLLGKLIFQLKEKGVQTLWLEVRESNSARFLYEKIGFNEVDIRKNYYPKPSGGRENAVVMACYL
Acetylates the N-terminal alanine of ribosomal protein S18.
P44305
B4TJ42
KEFC_SALHS
K(+)/H(+) antiporter
Salmonella
MDSHTLLQALIYLGSAALIVPIAVRLGLGSVLGYLIAGCIIGPWGLRLVTDAESILHFAEIGVVLMLFVIGLELDPQRLWKLRASVFGGGALQMVVCGGLIGLFCMFLGLRWQVAELIGMTLALSSTAIAMQAMNERNLTVSQVGRSAFAVLLFQDIAAIPLVAMIPLLAASGASTTLGAFALSALKVAGALALVVLLGRYVTRPALRFVARSGLREVFSAVALFLVFGFGLLLEEVGLSMAMGAFLAGVLLASSEYRHALESDIEPFKGLLLGLFFIGVGMSIDFGTLVENPLRILLLLAGFLAIKIVMLWLVARPLGVPAKQRRWFAVLLGQGSEFAFVVFGAAQMAGVLEPEWAKALTLAVALSMAATPIFLMLLTRMEKTEKGEAREADEIDEEQPRVIVAGFGRFGQIAGRLLLSSGVKMVVLDHDPDHIETLRKFGMKVFYGDATRMDLLESAGAAKAEVLINAIDDPQTNLQLSELVKSHFPHLQIIARARDVDHYIRLRQAGVAMPERETFEGALKSGRQALEALGLGRYEARERADLFRHFNTRMVEEMAKGENDPLSRAAAYKRTSAMLSEIITEDREHLSLIQRHGWQGTAEGKHSGEAADEPEVKPSI
Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport.
B4TJ42
C3K330
GLPE_PSEFS
Thiosulfate sulfurtransferase GlpE
Pseudomonas
MSEFKRIPPEHAQALREQGAVVVDIRDQPTYAAGHITGAQHVDNVNIADFIRAADLDAPVIVACYHGNSSQSAAAYLVSQGFSDVYSLDGGFELWRTTYPAEISSGNSQ
Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide.
C3K330
B7HJE9
NAMA_BACC4
NADPH dehydrogenase
Bacillus cereus group
MNSKLFSPYTIKNVTLKNRIVMSPMCMYSSGNEDGSVTNFHLIHYGTRAAGQVGLVMVEATAVLAEGRISNKDLGIWDDNLIEGLHKTTTFIHDNGAKAAIQLAHAGRKAELDTNAFAPSAIPFNDKMKIPVEMNIQQIKETILAFQRAALRSKQAGFDVIELHGAHGYLINEFLSPLTNKRTDKYGGSPENRYRFLREIIDSVNEVWDGPIFVRISANDYHPDGLTVQDYVQYTKWMKEQGIDLIDCSSGAVVPAHIDVYPGYQVQYAKHIKEHTKIATGAVGLITTGSQAEQILNNNEADLIFIGRELLRNPYFPRIAANELGFELQEPYQYKRAPGKIHTNK
Catalyzes the reduction of the double bond of an array of alpha,beta-unsaturated aldehydes and ketones. It also reduces the nitro group of nitroester and nitroaromatic compounds. It could have a role in detoxification processes.
B7HJE9
Q5LH44
DXS_BACFN
1-deoxyxylulose-5-phosphate synthase
Bacteroides
MKNEPTYSLLNAINYPKDLRQLSVDQLPEVCEELRQDIIKELSCNPGHFAASLGVVELTVALHYVYNTPYDRIVWDVGHQAYGHKILTGRREAFSTNRKLGGIRPFPSPEESEYDTFTCGHASNSISAALGMAVAAERKGEKDRHVVAVIGDGSMSGGLAFEGLNNASSTANNLLIILNDNDMAIDRSVGGMKQYLFNLTTSNRYNQLRFKTSRLLFKMGLLNEERRKALIRLGNSLKSLAAQQQNIFEGMNIRYFGPIDGHDVKNIARILHDIKDMQGPKILHLHTIKGKGFGPAEKQATIWHAPGKFDPVTGKRIVANTDGMPPLFQDVFGHTLVELAEKNKRIMGVTPAMPSGCSMNMLMDRMPDRAFDVGIAEGHAVTFSGGMAKDGLLPFCNIYSSFMQRAYDNIIHDVAIQKLNVVFCLDRAGLVGEDGPTHHGVFDMAYLRPIPNLTISSPMDEHELRRLMYTAQLPDKGPFAIRYPRGRGSLVDWECPLEEIPVGKGRKLKDGNDLAVITIGPIGKLAARAIERAEADTGISVAHYDLRFLKPLDEELLHEVGKKFRHIVTIEDGIIKGGMGCAILEFMADNGYYPEIRRIGVPDQFIEHGSVQQLYHLCGMDEEGIYKVITKNKLRMDAPVESCMATHS
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
Q5LH44
Q72R59
FLAB_LEPIC
Flagellin class B
Leptospira
MIINHNLSAVNAHRSLKFNELAVDKTMKALSSGMRINSAADDASGLAVSEKLRTQVNGLRQAERNTEDGMSFIQTAEGFLEQTSNIIQRIRVLAIQTSNGIYSNEDRQLVQVEVSALVDEVDRIASQAEFNKFKLFEGQFARGSRVASMWFHMGPNQNQRERFYIGTMTSKALKLVKADGRPIAISSPGEANDVIGLADAALTKIMKQRADMGAYYNRLEYTAKGLMGAYENMQASESRIRDADMAEEVVSLTTKQILVQSGTAMLAQANMKPNSVLKLLQQI
Component of the core of the flagella.
Q72R59
Q0K634
RL6_CUPNH
50S ribosomal protein L6
Cupriavidus
MSRVGKAPIALPKGAEVNVAAGVLSVKGPLGTLSQPIHSLVKVNVENDTLTFSPADESREANALQGTMRALVANMVKGVTTGFERKLNLVGVGYRAQLQGAALKLQLGFSHDVIHEMPEGVKAETPTQTEIIIKGADKQKVGQVAAEVRAYRPPEPYKGKGVRYSDERVILKETKKK
This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
Q0K634
Q9M373
AGP20_ARATH
Arabinogalactan peptide 20
Arabidopsis
MASRNSVAVIALFAFVFAVISPFAGAQSLAPAPSPTSDGTSIDQGIAYLLMVVALVLTYLIHPLDASSSSYTFF
Proteoglycan that seems to be implicated in diverse developmental roles such as differentiation, cell-cell recognition, embryogenesis and programmed cell death.
Q9M373
Q0RE66
MDH_FRAAA
Malate dehydrogenase
Frankia
MSSTPVNVTVTGAAGQIGYALLFRIASGQLLGADTPVRLRLLEIPQAVRAAEGTALELEDSAFPLLAGVDVFDDAKRAFEGTNVALLVGARPRTKGMERGDLLSANGGIFKPQGEAINSGAAEDIRVLVVGNPANTNALIAQTHAPDVPAERFTAMTRLDHNRAIAQLAKKLGVPSAEIRKITIWGNHSATQYPDIFHAQVGGRSGAEAVGDQKWIAEEFIPRVAKRGAEIIEVRGASSAASAASAAIDHVYTWVNGTPEGDWTSAAIPSDGSYGVPEGLISSFPVTAAGGKFEIVQGLELDAFSREKIDASVRELAEEREAVRALGLI
Catalyzes the reversible oxidation of malate to oxaloacetate.
Q0RE66
Q8FQZ4
ISPE_COREF
4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase
Corynebacterium
MRITARAWGKINLHLGVGPAREDGYHELVTVFQTIDLAETITLTTLEDELVEEGSVVRQLTVTGPRGVPTTPDNLAWRAVDALVGRRREHDRTPLPAVELHIDKGIPVAGGMAGGSADAAAALRAVDAWIGPFGEETLLEVAAELGSDVPFCLLGGTKLGTGRGEQLVDMLSRGTYHWALVVSPKGLSTPEVFAKFDEMSLPSSMDVTPMSQALLDGSAGALAEVLENDLAPAALSLRPDLRKTQLAGLRAGALATMVSGSGPTIALLCDDAQSARDVADALMDEGVGLSVHPATSPVPGPAKNRGAHIVSIESE
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
Q8FQZ4
C3PPA3
RS19_RICAE
30S ribosomal protein S19
spotted fever group
MARSIWKGPFVDGYLIKKVQKLMESGKSEMIKTWSRRSTILPIFVGFTFSVHNGNKFIPVSVNEEMVGRKLGEFAPTRTFHGHGADKKIKRK
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
C3PPA3
Q69XJ0
SPX1_ORYSJ
Protein SPX DOMAIN GENE 1
Oryza sativa
MKFGKSLSSQIVETLPEWRDKFLSYKDLKKRLKLIGGGGGGEERQAKRARVAADGGEEEAAAAAMTPEEAGFMRLLEAELDKFNSFFVEKEEEYIIRQKELQDRVARAAGRESKEELMRVRKEIVDFHGEMVLLENYSALNYTGLVKILKKYDKRTGALIRLPFIQKVLQQPFFTTDLLYKLVKQCEAMLDQLLPSNELSVSSEDGRGDSTNEDKPSNPSSSLVNGGTIPELDEIEYMESMYMKGTVAALRSLKEIRSGSSTVSAFSLPPLQGDSSPEEQQELWNKIPVIEQAAK
Involved in plant adaptation to phosphate starvation . Inhibits PHR2 DNA-binding activity via a Pi-dependent protein interaction . Suppresses the regulation on expression of PT2 by PHR2 and accumulation of shoot Pi . Optimizes growth under phosphate-limited conditions through a negative feedback loop of the PSI (phosphate starvation-induced) signaling pathway . Regulates the expression of SPX2, SPX3 and SPX5 . May be an important link between signal transduction pathways related to phosphate starvation and cold stress .
Q69XJ0
Q12645
PID9_FUSVN
Cytochrome P450 57A1
Fusarium solani species complex
MLVDTGLGLISELQAKLGWAVLLQIVPITIVAYNLLWFIYASFFSSLRKIPGPFLARISRVWEMKKTATGNIHEIMMDLHRRHGAIVRIGPRRYDFDTMEALKIIYRIGNALPKADYYKPFGLPSFPNLFDEQNPARHSAIKKQVASLYTMTALLSYEEGVDGQTAILKEQLQRFCDQKQVIDLPRFLQYYAFDVIGVITVGKSMGMMESNSDTNGACSALDGMWHYASMMAYIPNMHAWWLRLSSLLPIEVPIKGLTEYVERRIIQYRLKAAEFGDDAALKGENNFLAKLLLMEKKGTVTPVETQQAVGLNIGAGSDTTANALSTILYYLYTNPRTLHTLREELERYVKDGPISFQQSQSMPYLQAVIKEALRLHPGVGTQLTRVVPKGGLVIEGQFFPEGTEVGVNGWALYHNKAIFGNDASIFRPERWLEANENINIGGSFAFGAGSRSCIGKNISILEMSKAIPQIVRNFDIEINHGDMTWKNECWWFVKPEYKAMIKPRRCCLSRDESLV
Can detoxify the phytoalexin pisatin from garden pea. Pisatin is an antimicrobial compound produced by pea in response to infection by plant pathogens.
Q12645
B8GIX8
DTDA_METPE
D-tyrosyl-tRNA(Tyr) deacylase
Methanosphaerula
MKITLVNSRLDPAGVTIREQIQVLLADPEYQREGIDWEFLEIDGRLIHQERIDTGLNSDLLIFLSRHTSRRPVPVLTVHPTGNPGEALLGGEAGSFAPAAPGWMQAVLQNLVRLVPDGYQASYEVTHHGPTTLSTPSFFVEIGSTDHEWSDPVAGAAVAEAVLTAAPVDPISLIGFGGTHYAPRETAVALETRGAFGHILHSREIGGLTGSLLAKIATAAEAEAVYIDRKAIDRPALDHLYALLEETDLPVLGEKELHQIGSLSWQEYRSLRQIAGDAAPGAHLVIGTLPGGGTPVTATVPADLLAQAISADQGRVMTAIGRMPVVGLTGRGGLLLPIIITYERYRSQIIHDLITLCVKTIREEQHAVIDGDRLIIKKERFDPGLAASLGVPPGALFGMLKGGQAVRVGDQVIKPEMVRSCTVTAIHLRGLERYT
D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.
B8GIX8
O87940
TDIR_THAAR
Transcriptional regulatory protein TdiR
Thauera
MQATKTGNASTVFVVDDEASVRDSLTWLLNSISLDVRTFESAKDFLDADISCTHGCVVLDVRMQNVSGLQLQQALSERGFKLPIIFLSAYGDAQMGAQAVKKGAFDFLQKPYRNQDLLDAVNAALALNREMADKQNEKQKHLDLLATLSQREMEILDKVVAGSSSKEIAKLLGISYKTVEAHRGRIISKLGLKSTGDLMHFVMRGSSHCSDCGRQPLPGSSPCRPAA
Member of the two-component regulatory system TdiR/TdiS, which probably regulates transcription of toluene catabolic genes (bss operon). Binds to DNA.
O87940
C1DCC3
ENO_LARHH
2-phosphoglycerate dehydratase
Laribacter
MSSIVDVIAREILDSRGNPTVECDVWLDSGVMGRAAVPSGASTGEKEALELRDGDARRYLGKGVLKAVEHVNNEICEALIGLDPTDQAYIDQTLLELDGTDNKGSLGANAILAVSVAVAKAAALEVGLPLYRYLGGSGPMSLPVPMMNVINGGAHANNTLDIQEFMIMPVGARSFREALRCGAEIFHTLKKICADKGYSTAVGDEGGFAPNLARNEDAIKLILEATDKAGYVPGEDVLIALDCASSEFYKDGKYHLAGENLALSSEEFTNYLATLCDNYPIISIEDGMSEHDWAGWKLLTDKLGDKVQLVGDDVFVTNPAILAEGIKQGICNSLLVKINQIGSLSETLKAVDLAKRSGYTSVMSHRSGETEDSTIADLAVATNCMQIKTGSLSRSDRMAKYNQLLRIEEELGSAASYPGRAAFYHLK
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
C1DCC3
B0S0K8
RECR_FINM2
Recombination protein RecR
Finegoldia
MSLYPKAMDELIKNLSNLPTIGRKSARRLAYRIIDMDPKKVDELVESIVNVKTNIRPCANCGNLTDKKLCDICSDQKRDNSVITVVEDSMNVISIEKTGEYNGKYHVLGGLLSPRDNIAPQDLNLENLFLRCKKDYVKEVILALSPTTNGDLTTNFIIEVLKNEEYNVKVSRIAMGVPLGANLEYYDEMSLYKAILDRREIK
May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.
B0S0K8
Q865X5
IL4_LAMGL
Lymphocyte stimulatory factor 1
Lama
MGLTSQLIPTLVCLLVCTSNFAHGHKCDITLQEIIKTLNTLTARKNSCMELTVADVFAAPKNTTEKETFCKAATALRHIYRHHNCLSKHLSGLDRNLSGLANTTCSVNDSKKSTLRDFLERLKKIMKEKYSKC
Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4.
Q865X5
Q91VZ6
SMAP1_MOUSE
Stromal membrane-associated protein 1
Mus
MATRSCREKAQKLNEQHQLILSKLLREEDNKYCADCEAKGPRWASWNIGVFICIRCAGIHRNLGVHISRVKSVNLDQWTPEQIQCMQDMGNTKARLLYEANLPENFRRPQTDQAVEFFIRDKYEKKKYYDKNAIAITNKEKEKKKDEKKREKEPEKPAKPLTTEKLPKKEEQQLEPKKSTSPKNAAEPTIDLLGLDGPAEAPVTNGNPATAPALSDDLDIFGPMISNPLPAAVMPPAQGTASVPAPATLSTVTSGDLDLFTEQTTKSEEVAKKQLSKDSILSLYGTGAQQSTPGVFMGPTNIPFTSQAPTAFQGFPSMGVPVPAAPGLIGNMMGQNTGMMVGMPMHNGFMGNAQTGVMPLPQNVVGPQGGMVGQMGAPQSKFGLPQAQQPQWNLSQMNQQMAAMNLSSANASAGFGQPPSTTAGWSGSSSGQTLSTQLWK
GTPase activating protein that acts on ARF6. Plays a role in clathrin-dependent endocytosis. May play a role in erythropoiesis.
Q91VZ6
D5EXZ4
AXFA_PRER2
Ferulic acid esterase
Prevotella
MYQSTLKTILLASALLILPASMSAQKRKAAPKKAATEQVGKPDPNFYIFLCFGQSNMEGNARPEAQDLTSPGPRFLLMPAVDFPEKGRKMGEWCEASAPLCRPNTGLTPADWFGRTLVASLPENIKIGVIHVAIGGIDIKGFLPDSIQNYLKVAPNWMKGMLAAYDNNPYERLVTLAKKAQKDGVIKGILMHQGETNTGDPKWAGMVKQVYDNLCGDLNLKPEEVNLYAGNIVQADGKGVCIGCKKQIDELPLTLHTSQVISSDGCTNGPDRLHFDAAGYRELGCRYGEAVARHLGYEPKRPYIEMPKQIEVPADAFIAETTVPGNEFPKVDKEGRAYFRIAAPEARKVVLDICNKKYDMQRDGKGNFMAVTDPLPVGFHYYFLNINGVNFIDPSTETFFGCNRESGGIEIPEGSEGDYYRPQQGVPAGQVRSIYYYSNEQQTWRHAMVYTPAEYELAKNAKKRYPVLYLQHGMGEDETGWSKQGHMQHIMDNAIAKGEAVPMIVVMESGDIKAPFGGGNNQAGRSAYGASFYPVLLNDLIPYIDSNYRTKSDRENRAMAGLSWGGHQTFDVVLTNLDKFAWLGTFSGAIFGLDVKTAYDGVFANADEFNKKIHYMYMNWGEEDFIKSGDIVKQLRELGIKVDSNESKGTAHEWLTWRRGLNEFIPHLFKK
Involved in degradation of plant cell wall polysaccharides. Bifunctional esterase that possesses both acetyl esterase and ferulic acid esterase activities. Has deacetylase activity towards acetylated xylo-oligosaccharides smaller than xylo-heptaose, as well as from glucose-pentaacetate. Is also able to release ferulic acid from methylferulate, and from the more natural substrates wheat bran, corn fiber, and XOS(FA,Ac), a corn fiber-derived substrate enriched in O-acetyl and ferulic acid esters.
D5EXZ4
Q0AGN5
LEU1_NITEC
Alpha-isopropylmalate synthase
Nitrosomonas
MKERLVIFDTTLRDGEQSPGASMTMEEKVRIARQLERMGVDVIEAGFPAASKGDFEAVKAVAEAVSNSTVCGLSRAIEADINRAGEALQANQNMRIHTFIATSPIHMKNKLRMSPDRVIEQAIKAVKWARQYTDNVEFSPEDAGRSEIDFLCRILEAVIDAGARTLNIPDTVGYTMPDQFGGLIRTLRERIPNSDKAVFSVHCHNDLGLAVANSLSAVMNGARQVECTINGLGERAGNAALEEVVMAVRTRQDYFPCDTRIDTTQIVSTSKLVSGITGFPVQPNKAIVGANAFAHESGIHQDGVLKHRETYEIMRAEDVGWGANKLLLGKHSGRNAFRSRLKELGIELESEEKLNTIFIRFKDLADKKHEIFDEDLHALVSDEAQIPEEHYRLLSLVAHSETGEIPFAQVVIATGNNEQQAESEGSGPVDATFRAIEKILNSKAELQLFSVNNITSGTDALGEVTVRLQKVGRIVNGHGADTDIIAASAKAYLNACNKLHSSLERTHPQV
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Q0AGN5
Q6ME32
CLPP1_PARUW
Endopeptidase Clp 1
Candidatus Protochlamydia
MTRETSMPKHDKNKSAIPSKMADRIEHAILDSRRIFISDAVDSGSASEIIRKLWYLELTDPGKPILFVINSPGGAVDSGFAIWDQIKMITSPVTTLVTGLAASMGSILSLCASPGRRFATPHSRIMIHQPLLSGVIKGQATDLEIQAKEMLKTRNGLIEIYVQATGKNFAAIEKAIDRDTWMTAQEALEFGLLDKVINSFEEIEST
Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
Q6ME32
Q6D6H3
FLGH_PECAS
Basal body L-ring protein
Pectobacterium
MNAKSVIKPLRRPRLLALIAMLALNGCAYIPHDKVVTGPTTAQPGSPVLAGPNGSIFQTVQPMNYGYQPMFEDRRPRNIGDTLTIVLQENVSASKSSSANAARNGSSTFGVATTPRYLEGPLGNNRAALDATGTNDFSGKGGANANNTFSGTITVTVGQVLANGNLNVVGEKQIAINQGTEFIRFSGVVNPRTISGNNSVPSTQVADARIEYVGNGYINEAQNMGWLQRFFLNVSPF
Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
Q6D6H3
A8GCZ9
TRHO_SERP5
tRNA hydroxylation protein O
Serratia
MPVLHNRISNEELKARMLAETEPRTTVSFYKYFTIEDPKAFRDSLYVQFDKLKVFGRIYVAKEGINAQISVPQNKFEAFKAALFASHPALDQVRLNIALEDDGKSFWVLRLKVRERIVADGLDDESFNPANVGEYLQADRVNQMIDDPDTLFVDMRNHYEYEVGHFENAIEVPSDTFRDQLPMAVEMLQDNKDKNIVMYCTGGIRCEKASAYMLHNGFKNVYHVEGGIIEYARKAKEQGLPLKFVGKNFVFDERMGERISDDVIANCHQCGAPCDTHTNCLNDGCHLLFIQCPSCAAKFEGCCSEICREELKLPREEQRARRAGRENGIKIFNKSKGLLQTTMHIPAPEEDKDSAN
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
A8GCZ9
Q5IS50
DPP6_PANTR
Dipeptidyl peptidase VI
Pan
MTTAKEPSASGKSVQQQEQELVGSNPPQRNWKGIAIALLVILVICSLIVTSVILLTPAEDNSLSQKKKVTVEDLFSEDFKIHDPEAKWISDTEFIYREQKGTVRLWNVETNISTVLIEGKKIESLRAIRYEISPDREYALFSYNVEPIYQHSYTGYYVLSKIPHGDPQSLDPPEVSNAKLQYAGWGPKGQQLIFIFENNIYYCAHVGKQAIRVVSTGKEGVIYNGLSDWLYEEEILKTHIAHWWSPDGTRLAYATINDSRVPIMELPTYTGSIYPTVKPYHYPKAGSENPSISLHVIGLNGPTHDLEMMPPDDPRMREYYITMVKWATSTKVAVTWLNRAQNVSILTLCDATTGVCTKKHEDESEAWLHRQNEEPVFSKDGRKFFFIRAIPQGGRGKFYHITMSLSQPNSSNDNIQSITSGDWDVTKILAYDEKGNKIYFLSTEDLPRRRQLYSANTVGNFNRQCLSCDLVDNCTYFSASFSHSMDFFLLKCEGPGVPMVTVHNTTDKKKMFDLETNEHVKKAINDRQMPKVEYRDIEIDDYNLPMQILKPATFTDTTHYPLLLVVDGTPGSQSVAEKFEVSWETVMVSSHGAVVVKCDGRGSGFQGTKLLHEVRRRLGLLEEKDQMEAVRTMLKEQYIDRTRVAVFGKDYGGYLSTYILPAKGENQGQTFTCGSALSPITDFKLYASAFSERYLGLHGLDNRAYEMTKVAHRVSALEEQQFLIIHPTADEKIHFQHTAELITQLIRGKANYSLQIYPDESHYFTSSSLKQHLYRSIINFFVECFRIQDKLPTVTAKEDEEED
Promotes cell surface expression of the potassium channel KCND2. Modulates the activity and gating characteristics of the potassium channel KCND2. Has no dipeptidyl aminopeptidase activity.
Q5IS50
Q18KQ9
NOP10_HALWD
Ribosome biogenesis protein Nop10
Haloquadratum
MKSNIKICASWQKKHEQPVYTLADTCPKCNSVTKNTAPAPFDPTDAYGEYRRALKQRVRE
Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.
Q18KQ9
O52025
ARSM_HALSA
Arsenite methyltransferase
Halobacterium
MELWTHPTPAAPRLATSTRTRWRRTSRCSQPWATTPGTNSSDASRTPTTASASATSKPQSASARARSVRRSPDCTPRAWSRGARKDRGATTNRPRRPKFCSKRSTTCEATMSNDNETMVADRDPEETREMVRERYAGIATSGQDCCGDVGLDVSGDGGCCSDETEASGSERLGYDADDVASVADGADLGLGCGNPKAFAAMAPGETVLDLGSGAGFDCFLAAQEVGPDGHVIGVDMTPEMISKARENVAKNDAENVEFRLGEIGHLPVADESVNVVISNCVVNLAPEKQRVFDDTYRVLRPGGRVAISDVVQTAPFPDDVQMDPDSLTGCVAGASTVDDLKAMLDEAGFEAVEIAPKDESTEFISDWDADRDLGEYLVSATIEARKPARDD
Catalyzes the transfer of a methyl group from AdoMet to arsenite, producing methylated arsenicals.
O52025
Q1I169
SCX5_TITDI
P*T-beta* NaTx14.4
Tityus
IGMVVECKDGYLVGNDGCKYSCSTRPGHYCASECSRVKGKDGYCYAWLACYCYNMPNWAPIWNSATNRCRGRK
Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing.
Q1I169
P29552
ABDA_AEDAE
Homeobox protein abdominal-A homolog
Stegomyia
MSNPFDRVVCGDFAGPNGCPRRRGRQTYTRFQTLELEKEFHFNHYLTRRRRIEIAHALCLTERQIKIWFQNRRMKLKKELRAVKEINEQARREREEQDKMKNDSLKSAQQHHNSQKQQEQTIVGSQQSSGGGGGGGGGGGSSSLGSHLHHPSIVAQNDLKLGLGSMGVGVGVGGNLSMMGGLDNKTNQDILKARGSLVRESFFTVNETILRLRWTTREYVIVALFYPVAASSLLLKFRD
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
P29552
Q46DN2
SECG_METBF
Protein transport protein Sec61 subunit beta homolog
Methanosarcina
MAKKSGSGLQSSAGLMRYYEADKNAVQVQPKVVLIVGAIVGIAVLFLSAVNGFWP
Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.
Q46DN2
Q39688
EP1G_DAUCA
52/54 kDa medium protein
Daucus sect. Daucus
MARFFPLTLTILLFFIQRIDFCHTLVPANETFKFVNEGELGQYISEYFGDYRPLDPFTSPFQLCFYNQTPTAFTLALRMGLRRTESLMRWVWEANRGNPVDENATLTFGPDGNLVLARSNGQVAWQTSTANKGVVGLKILPNGNMVLYDSKGKFLWQSFDTPTDTLLVGQSLKMGAVTKLVSRASPGENVNGPYSLVMEPKGLHLYYKPTTSPKPIRYYSFSLFTKLNKNESLQNVTFEFENENDQGFAFLLSLKYGTSNSLGGASILNRIKYNTTLSFLRLEIDGNVKIYTYNDKVDYGAWEVTYTLFLKAPPPLFQVSLAATESESSECQLPKKCGNFGLCEESQCVGCPTSSGPVLAWSKTCEPPKLSSCGPKDFHYNKLGGWITT
May be involved in the limitation of water flow through the outer epidermal cell wall, either by direct modification of wall structure or as a signal instructing the protoplast to restrict water transport across the cell wall.
Q39688
Q7Z553
MDGA2_HUMAN
MAM domain-containing protein 1
Homo
MDLLYGLVWLLTVLLEGISGQGVYAPPTVRIVHSGLACNIEEERYSERVYTIREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVFNETLRITNIQRHQGGRYYCKAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVRYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPDKMVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAGAGRCSFLVTGKAYAPEFYYDTYNPVWQNRHRVYSYSLQWTQMNPDAVDRIVAYRLGIRQAGQQRWWEQEIKINGNIQKGELITYNLTELIKPEAYEVRLTPLTKFGEGDSTIRVIKYSAPVNPHLREFHCGFEDGNICLFTQDDTDNFDWTKQSTATRNTKYTPNTGPNADRSGSKEGFYMYIETSRPRLEGEKARLLSPVFSIAPKNPYGPTNTAYCFSFFYHMYGQHIGVLNVYLRLKGQTTIENPLWSSSGNKGQRWNEAHVNIYPITSFQLIFEGIRGPGIEGDIAIDDVSIAEGECAKQDLATKNSVDGAVGILVHIWLFPIIVLISILSPRR
May be involved in cell-cell interactions.
Q7Z553
Q8ZED3
RNFG_YERPE
Rnf electron transport complex subunit G
Yersinia
MLKTMRRHGITLALFAAGATGLTAVVNSLTENTIAHQAALQQKALLDQVVPAENYDNDMQAECYVVTDSALGNMAPHRLYLARKGNQPVAAAIETTAPDGYSGAIQLLVGADFHGNVLGSRVIEHHETPGLGDKIDIRISDWINHFSGQHVTGDDDKRWAVKKDGGSFDQFTGATITPRAVVRAVKNAALYLQTLPPQLSRLPSCGEDQ
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
Q8ZED3
Q9V9I4
OR42B_DROME
Odorant receptor 42b
Sophophora
MVFELIRPAPLTEQKRSRDGCIYLYRAMKFIGWLPPKQGVLRYVYLTWTLMTFVWCTTYLPLGFLGSYMTQIKSFSPGEFLTSLQVCINAYGSSVKVAITYSMLWRLIKAKNILDQLDLRCTAMEEREKIHLVVARSNHAFLIFTFVYCGYAGSTYLSSVLSGRPPWQLYNPFIDWHDGTLKLWVASTLEYMVMSGAVLQDQLSDSYPLIYTLILRAHLDMLRERIRRLRSDENLSEAESYEELVKCVMDHKLILRYCAIIKPVIQGTIFTQFLLIGLVLGFTLINVFFFSDIWTGIASFMFVITILLQTFPFCYTCNLIMEDCESLTHAIFQSNWVDASRRYKTTLLYFLQNVQQPIVFIAGGIFQISMSSNISVAKFAFSVITITKQMNIADKFKTD
Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Involved in the behavioral responses to ethyl acetate and pentyl acetate.
Q9V9I4
Q2P0X3
TRUB_XANOM
tRNA-uridine isomerase
Xanthomonas
MKPRIAYRPLHGILLLDKPAGLSSNNALQAARRLLRAEKGGHTGSLDPLATGLLPLCFGEATKIAGLLLGSAKAYDAEIVLGVTTDTDDADGEPLRERAVPDVSEADLQVALAAFIGRIQQQAPIYSALKQGGEPLYAKARRGEVIDAPVREVEVQAIEVLGYSAPRLTLRVTCGSGTYIRSLARDLGEVLGCGAHIASLRRLWVEPFRAPQMITLEGLATALEAGAEAQTVLLPIEAGLADFARIVLDAALAARFRMGQRLRDAAFPTGQVAVFGPDGSPSGLGLVDADGRLSPQRLFNGLNEISVC
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
Q2P0X3
P67827
KC1A_BOVIN
CK1
Bos
MASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDWTMLKQKAAQQAASSSGQGQQAQTPTGF
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis. May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration.
P67827
Q66HY7
IF4E3_DANRE
Eukaryotic translation initiation factor 4E type 3
Danio
MAVPAAPNLQLNTARQSSPVNSTENDIHIDERELENITNHVEDGTSLPLHSPWTFWLDRSLPGTTAAECESNLKKIYTVHTVQSFWSVYNNIPPVSCLPLRCSYHLMRGERRPLWEEESNAKGGVWKMKVPKESTLAVWKELLLATIGEQFTDYCASEDEVVGVSVSVREREDVVQVWNGNASFANEANVLGRIYELLPQISFKAVFYKPHEEHHAFEGGRSRH
Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis.
Q66HY7
Q4FNM7
RS15_PELUB
30S ribosomal protein S15
Candidatus Pelagibacter
MTKKAEELKMHEKDTGSSEVQIALLTGKIETLSAHIKQFKKDKHSSVGLLRAVNRRKKLLEYLKKNKFDSYKNVLTQLNLRK
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
Q4FNM7
Q9TLU2
RK14_CYACA
50S ribosomal protein L14, chloroplastic
Cyanidium
MISVHTRLKVIDNSGGKEIMCIRVLGTNRKYATLGDVIIGVVKNAVPNMPVKKSDVVRAVVVRIKKTINRKNFFSVRFDDNAAVIIGSDGNPKGTRIFGPVARELRDKNFSKIASLAQEVV
Binds to 23S rRNA.
Q9TLU2
A1T5Q3
NTPP_MYCVP
Nucleotide pyrophosphatase
Mycolicibacterium
MTRVVLASASKGRLGVLRQAGIDPQVIVSAVDEDTLLAALDPDLPPEAVVAKLATAKALSVAAELPDELLADCVVIGCDSMLFLDGTLRGKPGSAEAARAQWESMAGSAGHLLTGHALLRISGGVITHTEGDTGSTKVHFGKPAEDEITRYVDSGEPIHVAGAFTLNGLGGWFVDRIEGDPSNVIGLSLPLVHRLVRRTGLSISDLWQR
Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
A1T5Q3
Q4WUS1
ABCI_ASPFU
ABC multidrug transporter I
Aspergillus subgen. Fumigati
MDEKPAVSESSNGSDVDSLSTASAYEQHRERLRDANPQGVTSHRSGVNVKEAEEEFSELNRQFSTISHQAHCLSKQISRASKPTGKTEDVERSDSPADSDEPWDLETALRGNRDAETAAGIRSKRIGVIWDNLTVRGMGGVKTYIKTFPDAIIDFFNVPETIMHMLGYGKKGKEFEILRNFRGVLQPGEMVLVLGRPGSGCTTFLKTITNQRFGYTSIDGDVLYGIFDADTFAKRFRGEAVYNQEDDVHQPTLTVKQTLGFALDTKTPGKRPLGVSKAEFREKVINMLLKMFNIEHTANTVIGNQFIRGVSGGERRRVSIAEMMITSATVLAWDNSTRGLDASTALDFAKSLRIMTNIYKTTTFVSLYQASENIYKQFDKVLVIDSGRQVFFGPASEARSYFESLGFKERPRQTTPDYLTGCTDPFEREFKEGRSEDDVPSTPDSLVEAFNRSSYSERLAQEMDAYRKKLEQEKHVYEDFEIANQEAKRKFTPKSSVYSIPFHLQIWALMQRQFLIKWQDRFAQTVSWITSTGVAIILGTVWLRLPKTSAGAFTRGGLLFISLLFNGFQAFSELVSTMMGRSIVNKHRQFTFYRPSALWIAQILVDTTFAIARILVFSIIVYFMCGLVLDAGAFFTFILIIVLGYLCMTCFFRVIGCMSPDFDYAMKFASVVITLFVLTSGYLIQWSSEQEWLRWLYYINPFGLGFAALMVNEFKDLTMTCTADSLVPSGPGYDDMASRVCTLAGGEPGSVIIPGASYLAKTFSYFPGDLWRNFGIMVALTVGFLTLNLYHGETLQFGAGGRTVTFYQKENKERRALNGALMEKRTNRESKDQSAANLKITSKSVFTWEDVCYDVPVPSGTRRLLQSVYGYVQPGKLTALMGASGAGKTTLLDVLASRKNIGVISGNILVDGAPPPGSFLRTVSYAEQLDIHEPMQTVREALRFSADLRQPYETPQSEKYEYVEGIIQLLELEDLADAIIGTPETGLSVEERKRVTIGVELAAKPELLLFLDEPTSGLDSQSAFNIIRFLRKLAAAGQAILCTIHQPNSALFENFDRLLLLQRGGECVYFGDIGEDSHVLLDYFRRNGADCPPDANPAEWMLDAIGAGQTRRIGDRDWGEIWRTSSEFEQVKREIIQIKAQRAEEVRQSGGSQIIVREYATPLWHQIKVVCKRTNIVFWRSRNYGFTRLFNHVVIALVTGLAFLNLDDSRASLQYRIFVIFNVTVLPAIILQQVEPRFEFSRLVFFRESACKSYSQFAFALSMVIAELPYSILCAVCFFLPLYYIPGFQAAPSRAGYQFLMVLITELFSVTLGQMISALTPNSFIASQINPPIVIIFSLFCGVAIPRPQMPGFWRAWLYQLDPFTRLISGMVTTELHGRTVSCSPSEFNRFQAPENQTCGEYMLPFFERGGLGYLADNTTQACEYCAYKIGDEFYSAFSMSFNTRWRDLGIFLAFIGSNLIILFLAVSFMSPRCRLRYKLIYDIF
ABC efflux transporter that confers resistance to fluconazole (FLC) but shows no resistance to other azoles . Is also able to transport rhodamine 6G (R-6G), a known substrate for many ABC transporters .
Q4WUS1
Q87QY1
LFTR_VIBPA
Phenyalanyltransferase
Vibrio
MAIYLTELDSTFNFPSPYEALSDPNGLLAFGGDLDPHRILSGYYQGIFPWYGPGEPILWWSPSPRAVFDPLTFKPSKSLKKFQRKHQYKVTINQATEHVIQLCSSTRPADETWLNEEMQAAYIQLSNLGHCHSVEVWHDNTLVGGLYGISVGQLFCGESMFSLKDNASKIALWYLCTHLASKHGQLIDCQVMNPHLASLGAFELDRDEFIQKLLSLREKQTASDTFTPQVLQDSES
Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.
Q87QY1
P13104
TPM1_DANRE
Tropomyosin-1
Danio
MDAIKKKMQMLKLDKENALDRAEQAETDKKAAEERSKQLEDDLVALQKKLKATEDELDKYSEALKDAQEKLELAEKKATDAEGDVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKLVIVEGELERTEERAELNEGKCSELEEELKTVTNNMKSLEAQAEKYSAKEDKYEEEIKVLTDKLKEAETRAEFAERSVAKLEKTIDDLEDELYAQKLKYKAISEELDHALNDMTSI
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.
P13104
Q71XT8
TSAD_LISMF
tRNA threonylcarbamoyladenosine biosynthesis protein TsaD
Listeria
MGGLMKKNTLILGIESSCDETAASVVKNGNEIISSVVASQIESHKRFGGVVPEIASRHHVEQITLVIEEALKQANVTMDDLDGIAVTEGPGLVGALLIGVNAAKTLAFMHNLPLVGVHHIAGHIYANRFETEFKFPLLSLVVSGGHTELVLMKADNEFEIIGETRDDAAGEAYDKVARTLGLAYPGGVQIDKLAKDGEDTFHFPRAMMDEGSFDFSFSGLKSSFINTLHNLRQRGEEPNPNDMAASFQASVVDVLVSKTIRAAKQYDVKQLLLAGGVAANQGLRERLIQEVKLELPETELIIPPLALCGDNAAMIAAAGTVSFLQGKRSGFDMNANPGLLLEDI
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.
Q71XT8
Q03KJ9
DEOB_STRTD
Phosphodeoxyribomutase
Streptococcus
MSKFNRMHLIVLDSVGIGAAPDANNFVNAGVPDGASDTLGHISKTVGLNVPNMAKLGLGNIPREQPLKTVPAESNPTGYATKLEEVSLGKDTMTGHWEIMGLNITEPFDTFWNGFPEEILTQIEEFSGRKVIRESNRPYSGTAVIDDFGPRQMETGELIIYTSADPVLQIAAHEDIIPVEELYRICEFARSITLERPALLGRIIARPYVGEPGNFTRTSNRRDLAISPFAPTVLDKLNEAGIDTYSVGKISDIFNGEGINHDMGHNKSNNHGVDNLIKAMTSEDFKHGFSFTNLVDFDALYGHRRNPQGYRDCLHEFDERLPEIIAAMKEDDLLMITADHGNDPTYAGTDHTREYIPFLAYSPSFKCSGLIPVGHFADISATIADNFGVEKAMIGESFLDKLV
Phosphotransfer between the C1 and C5 carbon atoms of pentose.
Q03KJ9
Q29RQ5
TRIM9_BOVIN
Tripartite motif-containing protein 9
Bos
MEEMEEELKCPVCGSFYREPIILPCSHNICQACARNILVQTPESESPQSRRASGSGVSDYDYLDLDKMSLYSEADSGYGSYGGFASAPTTPCQKSPNGVRVFPPAMPPPATHLSPALASVPRNSCITCPQCHRSLILDDRGLRGFPKNRVLEGVIDRYQQSKAAALKCQLCEKAPKEATVMCEQCDVFYCDPCRLRCHPPRGPLAKHRLVPPAQGRVSRRLSPRKVSTCTDHELENHSMYCVQCKMPVCYQCLEEGKHSSHEVKALGAMWKLHKSQLSQALNGLSDRAKEAKEFLVQLRNMVQQIQENSVEFEACLVAQCDALIDALNRRKAQLLARVNKEHEHKLKVVRDQISHCTVKLRQTTGLMEYCLEVIKENDPSGFLQISDALIRRVHLTEDQWGKGTLTPRMTTDFDLSLDNSPLLQSIHQLDFVQMKASSPVPATPILQLEDCCTHNNSATLSWKQPPLSTVPAEGYILELDDGNGGQFREVYVGKETMCTVDGLHFNSTYNARIKAFNKTGVSQYSKTLVLQTSEVAWFAFDPGSAHSDIIFSNDNLTVTCSSYDDRVVLGKTGFSKGVHYWELTVDRYDNHPDPAFGVARIDVMKDVMLGKDDKAWAMYVDNNRSWFMHNNSHTNRTEGGITKGATIGVLLDFNRKTLTFFINDEQQGPIAFENVEGLFFPAVSLNRNVQVTLHTGLQVPDFYSSRASIA
E3 ubiquitin-protein ligase which ubiquitinates itself in cooperation with an E2 enzyme UBE2D2/UBC4 and serves as a targeting signal for proteasomal degradation. May play a role in regulation of neuronal functions. May act as a regulator of synaptic vesicle exocytosis by controlling the availability of SNAP25 for the SNARE complex formation.
Q29RQ5
P11409
MTP2_PROHU
N-4 cytosine-specific methyltransferase PvuII
Proteus
MMTLNLQTMSSNDMLNFGKKPAYTTSNGSMYIGDSLELLESFPDESISLVMTSPPFALQRKKEYGNLEQHEYVDWFLSFAKVVNKKLKPDGSFVVDFGGAYMKGVPARSIYNFRVLIRMIDEVGFFLAEDFYWFNPSKLPSPIEWVNKRKIRVKDAVNTVWWFSKTEWPKSDITKVLAPYSDRMKKLIEDPDKFYTPKTRPSGHDIGKSFSKDNGGSIPPNLLQISNSESNGQYLANCKLMGIKAHPARFPAKLPEFFIRMLTEPDDLVVDIFGGSNTTGLVAERESRKWISFEMKPEYVAASAFRFLDNNISEEKITDIYNRILNGESLDLNSII
A beta subtype methylase, recognizes the double-stranded sequence 5'-CAGCTG-3', methylates C-4 on both strands, and protects the DNA from cleavage by the PvuII endonuclease.
P11409
B5ZB76
ENGB_UREU1
Probable GTP-binding protein EngB
Ureaplasma
MAKFIKSAQYFDQYPVDKQFEICVIGRSNVGKSSLINALANEKIARTSNTPGRTQLVNFFDFNSFRLVDLPGYGFARVSKDKQLDLATIIDQYLGYRQNLCAVFQICDINVLTNDDVEMSRYFENQNYAHFVVLNKVDKVNKSHFDNNKQKIAKFLNISVDRLLCVSAQKNTNVATLFALMKKVVIETRQKQLLLKKEEKKSSEEEIK
Necessary for normal cell division and for the maintenance of normal septation.
B5ZB76
C3N652
COXX_SULIA
Heme O synthase
Sulfolobus
MSLQQKIKAYLKLGKLGVVSLLDLAAVAGAFLAYKHGISLLPIIPMFIGGTLASMGAMIINSGIEIDRDKVMSRTSKRPTVVGYVNRKEAIIVGSLLAILGTALGFIDNILTAFFIALGVVIYIFVYTILLKPRTWLNIVIGGFAGSAAAWAGYTSLTNSLTLEGFLLGFLIFMWTPGHFWSLALKYREDYVNAHYPMLPAVVGITTSARAIAISNALMIPIVLLLGYYINLIALIAFSILSLFLMFLSYRLILNPTKEEAIKSFIFSNIYLMLILLIMIIVKLI
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
C3N652
C1FKN5
HSLO_CLOBJ
Heat shock protein 33 homolog
Clostridium
MKDKLVKAIAKDGQVRIIGAITTELVNEGVRLHNCAPTAAAALGRMLTAGALMGTTLKSEKDTLTLQIHGGGIAKGVVVTSYADGHVKGYIGNPTADIEPNSKGKLDVSGIIGKNGNLLVIRDMGLKEPYIGQVPIYTGEIGEDLAYYYTVSEQTPSAVGLGVLVDKDLSIKSAGGFIIQMMPGADEMLADLISYRLEEIPSITEMISKGMTIEEILEYIFEDMDLNILESIVPEYRCDCSREKVERALASIGQKDLKEIYDEVKEEELKCHFCNKAYAFSHDEIGNILESYYNEK
Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.
C1FKN5
A7FP85
FDHD_YERP3
Sulfur carrier protein FdhD
Yersinia
MSQIKPSRLSSSAEIRGARQLDVLQRHKLAEPQQDWLAEEVPVALVYNGISHVVMMATPKDLAAFALGFSLSEGIISSPQEIYAIEITPGCNGIEVNIELSSRRFAGLKERRRAMAGRTGCGVCGIEQLDDIFRPITPLPFTQAFNLEHLDTALAQLKQVQPVGQLTGCTHAAAWINPEGELLGGCEDVGRHVALDKLLGIRAKQPWQQGAVLVSSRASYEMVQKTAMCGAEILFAVSAATTLAVEVAERCNLTLVGFSKPGRATVYTHPQRIK
Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.
A7FP85
A8A6R1
CYAY_ECOHS
Iron-sulfur cluster assembly protein CyaY
Escherichia
MNDSEFHRLADQLWLTIEERLDYWDGDSDIDCEINGGVLTITFENGSKIIINRQEPLHQVWLATKQGGYHFDLKGDEWICDRSGETFWDLLEQAATQQAGETVSFR
Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis.
A8A6R1
A3GGU2
EIF3G_PICST
Translation initiation factor eIF3 p33 subunit homolog
Scheffersomyces
MSTTVIGSWADAGDEFSAPDITTNPDGTKTVITYRTNQDGKKVKITQKIKEVKVQERVHPLIAQRKNWKKYGKESKSPPGPDTSTTQLGEKVELKLGTSWKQQEKEEEEEKAENRAQKLSVQTIRCRTCGGDHYTSKCPFKDTLGATTSSPAAESGAGDNGPGKYVPRHLRADANGNLPSKEGRDDSTTLKVSQLNSFVDEDMLRNELFARFGPLQRVTLVRNRETGDSRGFAYVSFITEDMAQRALDALNGKGYHSLILHLEWSKKKKTV
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA.
A3GGU2
A3DJF7
HIS6_ACET2
ImGP synthase subunit HisF
Acetivibrio
MVTKRIIPCLDVHNGRVVKGVNFVNIRDAGDPVEIASYYDKAGADELTFLDITASAEARNIMIDVVRRVAEQVFIPFTVGGGIRTVEDFREILKAGADKVSINSAAVKRPELISEAASRFGSQCVVVAIDAKRRDDNSGWDVYINGGRINTGKDAVEWAVEVEKLGAGEILLTSMDCDGTKKGYDIELTRKVSESVRIPVIASGGAGTMEHFREALVEGKADAVLAASLFHYREIEIMELKKYLKENGIEIRM
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
A3DJF7
Q9VZI2
ACK_DROME
Activated Cdc42 kinase Ack
Sophophora
MTSTSAVDGGLGSETAWLEDLLREVQLEQFLDRIRDDLQVTRLAHFDYVLPDDLERCGLGKPAIRRLMEAVRKKKAHQWRKNILSKLIGGGKQPSSKKQSSAARESSQGNGTQLTCLIHEKDITMGLKLGDGSFGVVRRGEWSASPAGKVIPVAVKVLKSDNLTQPGIIDDFFREVQAMHALDHANLVRLYGVVLSQPMMMITELAERGSLLDTLRKQCRHTSLTIIWNWSVQIVTGMAYLEQKRFLHRDLACRNVLLAAGNKIKIGDFGLMRALPQEDDCYVMSEHKKVPFPWCAPESLRFRQFSHASDTWMFGVTLWEMFSFGEDPWVGLNGSQILRKIDREGERLHQPDACPPDVYAMMLQCWDKTPAERPTFAALKEYLASMSPPVMRASRSHHESKGLQIEPGDTIAIIDGRHELKLIKGQNQRTFDIGIFPRNLLEQRKVGAAGDVVMRSSVGNGSSSSPFGFCWGGAAAMANGDDRQRKCASMTNQPHAKERKSTSSKQFAYNKLVNDSATGLQRRNAVKHKGVVVGPQRPPPPQFQQEGILIDISPDMRPIAEAGTGGAKGAGDSSSLQADSSFCILDAPIDVPTYAGSSGSGDLNVSPTYYNEQPQFDFDPAKMTASPGRLQPPPYQMPPTYSNTMEFVQKRDLHQQQLATPVRERDPFDTTNVETTVALYSNFNQSLEAASPPAPIYNSPSVRKSLFGGSKSNKENIPALESAAMQLNLSNLTLERHDATCIQPVEPVPAPPGDGVLLDKSFIAELEKDMYSNGQNRAQEEYQRNSTQMYASKDMVYKQNLTPLKNGAAPGSVHSNHSSPSSTASPKQNNVEAAAAAAATTQSVVNRIWYEQVASTQSEYYAQPPTEQAEEQIYQNHRHQQQQQQELNHSFVAISNRVVAPKNNAYSSTASLYDAVAASTAGSTYYGQVPNGSGAVLYDEVTQDDYLRPTRPAPLAPPPLSAQQIQRRMEKMRLQQQQQLDGAHQLYAPVPSDYGREQEKLQQLMQELGSSAVEQDVRNALRAASGDVGLATRHYKIDQLARLGVAGRPQCEQALQQTNWSLEVAAELLLNAG
Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in diverse biological functions such as cell survival, cell differentiation, cell growth and proliferation . Phosphorylates SH3PX1 and ex . Phosphorylates SH3PX1 predominantly on 'Tyr-56', which likely promotes the recruitment of SH3PX1 to an axonal guidance receptor complex that includes dock and Dscam; because phosphorylation of SH3PX1 increases its interaction with the complex member dock while decreasing its interaction with the actin cytoskeleton modulator WASp . In the wing and eye, promotes tissue growth, and during embryogenesis coordinates cell shape changes required for correct dorsal closure . Functions in the negative regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway by enhancing yki activity thereby promoting cell proliferation and inhibiting apoptosis . This is accomplished, at least in part, by phosphorylating ex thereby reducing its ability to efficiently activate the Hippo signaling cascade . In the eye disk, wing disk and possibly spermatids, inhibits programmed cell death induced by hid and rpr through a mechanism that is independent of the MAP kinase signal transduction pathway . Essential for male and female fertility . During oogenesis required for the correct temporal assembly, and consequently the catalytic activity of long CTPsyn filaments (cytoophidium) in the germline nurse cells, likely by phosphorylating an unidentified substrate that is essential for linking individual CTPsyn filaments into large, catalytically active assemblies .
Q9VZI2
A1V292
HTPG_BURMS
High temperature protein G
pseudomallei group
MTQQTMSFQAEVKQLLHLMIHSLYSNKEIFLRELVSNASDAADKLRFEALENNALYESDPNLRIRLSFDKAARTITIDDNGIGMSRDEAIANLGTIARSGTKEFFSKLSGDQQKDAALIGQFGVGFYSGFIVADRITVETRRAGLPASEGVRWESAGEGDFQVDTIERAARGTTITLHLREGEDELLSSYRLKSIVQKYSDHVALPILMKKEEWDQEKGEMVEKDEDETINQASALWTRAKSEVTDEQYKQFYQHVAHDHQDPLAWTHNRVEGRSEYTQLLFVPSHAPFDLWNRDYRGGLKLYVKRVFIMDDAEQLLPQYLRFIKGVVDSSDLPLNVSREILQESRDVKAIREGVTKRALSMLEELANAEDDAGKEKYKTFWSAFGQVLKEGVGEDHANRERVAKLLRFASTHGDTDAQDVALADYVARMKPEQTKIYYVTADTWQAAKNSPHLEVFRKKGVEVLLLTDRVDEWMLSFLHEFDGKPLASVARGDLDLGALNDDEKKAQEETGEAMKPVVDKMKETLGEKVKDVRVTFRLTDSPSCLVADDNDMSGYLQRMLKAAGQSAPSFQPILEINPEHPLVKALKADGADFGDWCHLLFDQALLAEGGALEDPASFVKRTNALLLSRAA
Molecular chaperone. Has ATPase activity.
A1V292
Q0A7Z2
SYS_ALKEH
Seryl-tRNA(Ser/Sec) synthetase
Alkalilimnicola
MLDTRKLRQDPEGVARALARRGYRLDVAHYRALDERRRELQVRTQELQNERNTRSKGIGQAKARGEDIEPLKAEVADLGRQLEAAKGELQAVQDELHDIHVGMPNLPHPDVPEGEDDSENVEVRRWGTPPEFGFRPRDHVELGELLDGGLDFEAAAKLTGARFVVMRGAVARLHRALIQFMLDTHTAEHGYQEIYVPYMVNRDSLFGTGQLPKFAADLFHLDAEQDYYLIPTAEVPVTNMARDEIIADGQLPLKFACHTPCFRSEAGSHGKDTRGMIRQHQFEKVELVQMVRPEASWEALEALTGHAETILQRLDLPYRVVTLCTGDLGFSSAKTYDIEVWLPAQETYREISSCSNFLDFQARRMQARWRNPETGKPEPLHTLNGSGLAVGRCLVAILENYQEADGRVTVPEALRPYMGGITRL
Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
Q0A7Z2
Q3AY05
THF1_SYNS9
Protein Thf1
unclassified Synechococcus
MGERQTIADSKRAFHQAFPHVIAPLYRRLADELLVELHLLSHQSSFKTTPLFAVGLCTVFDTFSAGYRPEEHITGLLDALCSSNGYDANTFRKESKRCIDAAKTESVDAMDSHLAGQKLGEGSHYSRLMAIGVLRLFEEAKGDADQPDEADLRKRCKELSTALNFPAERVEKDLSLFASNSERMSAAIELVQETIAAERRKKERRQAEQAQRSES
May be involved in photosynthetic membrane biogenesis.
Q3AY05
P41746
RODL_ASPFU
Rodlet protein
Aspergillus subgen. Fumigati
MKFSLSAAVLAFAVSVAALPQHDVNAAGNGVGNKGNANVRFPVPDDITVKQATEKCGDQAQLSCCNKATYAGDVTDIDEGILAGTLKNLIGGGSGTEGLGLFNQCSKLDLQIPVIGIPIQALVNQKCKQNIACCQNSPSDASGSLIGLGLPCIALGSIL
Cell wall protein regularly arranged in interwoven fascicules of clustered proteinaceous microfibrils, or rodlets, to form the outer spore coat protein. It is involved in resistance to environmental stress and may well be associated with conidial hydrophobicity. It is important in the morphogenesis of the dispersible conidia.
P41746
Q8R7W9
RL6_CALS4
50S ribosomal protein L6
Caldanaerobacter
MSRIGRLPIPIPKGVEVKVSPDNVVTVKGAKGTLEKKFPPIVNIEVRDGEVVVTRKGDDKEERAMHGTTRAIIANMVKGVTEGFEKALEIVGVGYRAAKQGKKLILNVGYSHPVEIEEEPGIEIIVEGNNRIIVRGADKERVGQVAANIRRVREPDAYQGKGIRYVGEVVRLKEGKTGKK
This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
Q8R7W9
P53874
UBP10_YEAST
Ubiquitin-specific-processing protease 10
Saccharomyces
MTTQESIKPLVDRILSNPLQFNAAMISNKSNNNDTSAAPENSSYIVIGKQHNNNSNSTAIAATAESKQIKENNLIDRPNGKKTNTVPKSMAEALLLYTSKNDKDAADATGAKKSAELSTELSTEPPSSSSEDDKVGKEEEEEGEIFHEARDYVEPRKASLKERDNADKGDGEDIGEDIGEDIGEDIGEDIGEDIGENLGSPLATIDDSSNENEKEKRKELSTSISSDDEIEDDEDEDDMDYDSSAMEKELPEEEENDSSSKISEGEKKSLYQDLMENSTVEVNRYEPVNNTKENGNRNPKGEEEEEEEEELKHKSRSITPPVTISNLSNFYQFNENINDRGSLNSTRIVKNWGDKFTNLKPRGLLNHGVTCYTNAAVQAMLHIPSIQHYLFDILMGKYDSTISKNSVSYTLAETSKKMWLPVSKNPRKNVSASYINPKHLISRLDDINCMMSEWQQEDSHEYFMSLMSRLQEDSVPKGHKLIESIIYDIFGGLLKQIVTCKSCGSISKTEQPFYDLSLHLKGKKKLDPNSDLSSDSINGTSATTSTTTSNAATKPSLSSSSSVNLNNGSPFAAASDLSSANRRFSIEKSIKDFFNPELIKVDKEQKGYVCEKCHKTTNAVKHSSILRAPETLLVHLKKFRFNGTSSSKMKQAVSYPMFLDLTEYCESKELPVKYQLLSVVVHEGRSLSSGHYIAHCKQPDGSWATYDDEYINIISERDVLKEPNAYYLLYTRLTPKSVPLPLAKSAMATGNVTSKSKQEQAVNEPNNRPLKINSKKNNRKKWKKNKKRKFTK
Deubiquitinating enzyme involved in telomere and HM loci silencing, which is the repression of chromatin structure which leads to a stop in the transcription of nearby genes . Targets histone H2B for deubiquitination, thus helping to localize SIR2 to the telomere . At silent chromatin, including telomeres and the rDNA locus, not only maintains low H2B 'Lys-123' ubiquitination (H2BK123Ub), but also low H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively) . Controls the proliferating-cell nuclear antigen PCNA/POL30 deubiquitination which is crucial for keeping TLS polymerases in check as well as for down-regulating the error-free bypass . Deubiquitinates and stabilizes RPA190, the largest subunit of RNA polymerase I, to achieve optimal levels of ribosomes and cell growth . Protects also nutrient transporters such as GAP1 from ubiquitin-dependent endocytosis .
P53874
A1BHM3
ISPE_CHLPD
4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase
Chlorobium
MDHLSVKSFAKINLGLLITGKRKDGYHTLETIFAPINWYDTIGFSDSDVISMSCSNIDLPVDDNNLCIRAARALQQSASCSKGAAMNLQKVVPFGAGLGGGSSDAATVLRVLNELWKINVSSAELHELAVKLGADVPYFLEMKGLAFARGIGDELEDLGLTLPFHVVTVFPEEHISTVWAYKNFYQKFDRPVPDLRLLLQRLCLDGDRSVLGAFENDFEPAVFDHYPKVRVVKESLLDAGSFYASLSGSGSAVFGLFDTLENAAGAVCAMQQKGYRVTLTPPGFSMEAQAGSRL
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
A1BHM3
Q76MJ5
ERN2_HUMAN
Endoribonuclease
Homo
MASAVRGSRPWPRLGLQLQFAALLLGTLSPQVHTLRPENLLLVSTLDGSLHALSKQTGDLKWTLRDDPVIEGPMYVTEMAFLSDPADGSLYILGTQKQQGLMKLPFTIPELVHASPCRSSDGVFYTGRKQDAWFVVDPESGETQMTLTTEGPSTPRLYIGRTQYTVTMHDPRAPALRWNTTYRRYSAPPMDGSPGKYMSHLASCGMGLLLTVDPGSGTVLWTQDLGVPVMGVYTWHQDGLRQLPHLTLARDTLHFLALRWGHIRLPASGPRDTATLFSTLDTQLLMTLYVGKDETGFYVSKALVHTGVALVPRGLTLAPADGPTTDEVTLQVSGEREGSPSTAVRYPSGSVALPSQWLLIGHHELPPVLHTTMLRVHPTLGSGTAETRPPENTQAPAFFLELLSLSREKLWDSELHPEEKTPDSYLGLGPQDLLAASLTAVLLGGWILFVMRQQQPQVVEKQQETPLAPADFAHISQDAQSLHSGASRRSQKRLQSPSKQAQPLDDPEAEQLTVVGKISFNPKDVLGRGAGGTFVFRGQFEGRAVAVKRLLRECFGLVRREVQLLQESDRHPNVLRYFCTERGPQFHYIALELCRASLQEYVENPDLDRGGLEPEVVLQQLMSGLAHLHSLHIVHRDLKPGNILITGPDSQGLGRVVLSDFGLCKKLPAGRCSFSLHSGIPGTEGWMAPELLQLLPPDSPTSAVDIFSAGCVFYYVLSGGSHPFGDSLYRQANILTGAPCLAHLEEEVHDKVVARDLVGAMLSPLPQPRPSAPQVLAHPFFWSRAKQLQFFQDVSDWLEKESEQEPLVRALEAGGCAVVRDNWHEHISMPLQTDLRKFRSYKGTSVRDLLRAVRNKKHHYRELPVEVRQALGQVPDGFVQYFTNRFPRLLLHTHRAMRSCASESLFLPYYPPDSEARRPCPGATGR
Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins.
Q76MJ5
B4F103
SECM_PROMH
Secretion monitor
Proteus
MSIINFWRQFGRRYFWSHLLLGMVAAGIGMPSLVSAHAENPSQTDTPSSQNRQSQALIAFDNLFLRQSVQNPASSFTFNYWQQHAVKNVIKQLSFAFTIHSPELMVKAKDEPSPVANVAEVMLDTLYALLTQAPSSTLVNLPISRGVLTENRISYHTGLWLAQIRGIRAGPYLTA
Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation.
B4F103
Q5P9M7
SSRP_ANAMM
Small protein B
Anaplasma
MEIVAENRKARFDYFVLQEYDAGMVLVGSEVKSLRQRKVNMGDAYVLEKDMELWIHNLHISEYNRADRKNHKPLRVRKLLLRKREIHKIAGNIKVSGLAVVPLMIFFNNKGIAKIKIAIVKGKKLYDKREAIKTRDWQREKSRISRREV
Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
Q5P9M7
Q82M90
G6PI1_STRAW
Phosphohexose isomerase 1
Streptomyces
MSDSPRLTRRPEWTELEDHRAGPLLHPALRELFAADPERAERYVVRAGDLRLDYSKHLITDETLALLQELATATDVFGLRDAMFRGEKINVTENRAVLHTALRAPRDAVIEVDGENVVPAVHAVLDRMADFADRVRSGEWTGHTGSRIRTVVNIGIGGSDLGPAMAYEALRAFTDRSLTVRFVSNVDGADLHEAVRDLDPAETLFVIASKTFTTIETITNATSARSWLLAGLDGDEKAVAKHFVALSTNAGKVSDFGIDTANMFEFWDWVGGRYSFDSAIGLSLMIAIGPERFRELLDGFRIVDEHFRTAPAEANAPLLLGLLGVWYGSFFGAQSHAVLPYSHYLSKFTAYLQQLDMESNGKSVDRDGHPVEWQTGPVVWGTPGTNGQHAYYQLLHQGTKVIPADLIGFINPVDGLSDELAAQHDLLMANLFAQGQALAFGKTGDEVRAEGVPEEQVPHRTFRGNHPTTTILAAELTPSVLGQLIALYEHKVFVQGAIWNIDSFDQWGVELGKVLAKRVEPALTEGADVPGLDPSTAALVAAYRTHRKK
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
Q82M90
P79875
TPG_RANTE
Temporin-G
Rana
MFTLKKSLLLLFFLGTINLSLCEEERDADEERRDDLEERDVEVEKRFFPVIGRILNGILGK
Amphipathic alpha-helical antimicrobial peptide with activity against Gram-positive bacteria (M.luteus), Gram-negative bacteria (E.coli), and fungi (S.cerevisiae) . Stimulates insulin release from pancreatic beta-cells in a dose-dependent manner, without increasing intracellular calcium . Does not protects BRIN-BD11 beta-cells against cytokine-induced apoptosis . In vivo, intraperitoneal injection together with a glucose load into mice improves glucose tolerance with a concomitant increase in insulin secretion .
P79875
B5FP62
BIOF_SALDC
8-amino-7-ketopelargonate synthase
Salmonella
MSWQQRVDDALTARRATDTLRRRYVVSQGAGRWLVANGRQYLNFSSNDYLGLSQHPQIIRAWQQAATRFGVGSGGSGHISGYSVAHQALEEELAQWLGYPRALLFISGFAANQAVITALMKKNDRIVADRLSHASLLEAANLSPAQLRRFIHNDTQHLSRLLQSPCVGQQLVVTEGVYSMDGDSAPLAEIQHIARRHHAWLLVDDAHGIGVTGDEGRGTCWQRGGKPELLVVTFGKGFGVSGAAVLCSESVADYLLQFARHLVYSTSMPPAQAQALSASLAVIRSDEGRERREKLAALVQRFRAGVNASRFTLLNAHSAIQPLIVGDNSRALRLAEALRQQGCWATAIRPPTVPVGTARLRLTLTQAHEACDIDRLLEVLHGAGE
Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
B5FP62
Q72L31
DCUP_THET2
Uroporphyrinogen decarboxylase
Thermus
MDLVNDLILRAARGEPTPRPPVWFMRQAGRYQKAYRKLRERYTLPEIVQNPEVCAEVTLLPVKALGVDAAILFADITTPLYGMGVDLSLVENKGPVIHNPVRDEKGVEALRPLVPEEAVPFVLETIRILKRELPVPLIGFAGAPFTLASYLVEGGPSRRFLRVKALMYGEEALWHRLMEKLTEAMARYLRAQAEAGADLLQVFDSWVGALSPADYRRYVKPHMERLFQSLRPAGVPVIHFGVGTMGLLEDMKEAGGDVLGLDHHTPLPWARALLGATPVQGNLDPAVLLAPKGVIRREVQRILKENGGKSGHIFNLGHGIVPETPEENVRYVVELIQEVAA
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
Q72L31
C3PP47
RL25_RICAE
General stress protein CTC
spotted fever group
MSEILELEAESRTEFGTGAARALRRAGRVPAIIYGAGKTPVSISLEEKEITKYYRKPAFISQLINLTIDKKKYKVLPKAVELHPVTDIVRHVDFVFLEEKTQKMEVPVVYEGKERALGVKRGGYFNIVKRRVTLLCDVNNIPRNITIDVTNMPMATSLKSSKIELPKGCSFVTKKEFVLATIIGRRGAKTEAEGEQQAAEAGK
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
C3PP47
Q9S4Z0
METN_SALEN
Methionine import ATP-binding protein MetN
Salmonella
MIEIEKVCVDFTAGRGTSGAGKSTLLRTLNALTRPSQGRVNVNGVEISALDGKALRQARQRIGMIFQHFNLMHTRTVAQNVAFSLKAAGWERSKIAPRVAEILTLVGLADKANRFPVQLSGGQKQRVGIARAIANHPDVLLCDEPTSALDLETSATILALLRQINAQLGITIVLITHEMNVIKSICDRVAVMSGGKVVESGEVFDEFAHPQHAFTQQLVSHTLNLTLPERLREHLPGQLLKILFIGDSAEQPVLSEVAIKFGVAVNILHGKIEYIGERALGILVVQLTAPHNPTAVAAAVEHIRQRTAQVEVIRG
Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system.
Q9S4Z0
Q15Q18
MURC_PSEA6
UDP-N-acetylmuramoyl-L-alanine synthetase
Pseudoalteromonas
MIAPDKVHYHVPEMRRIKNIHFVGIGGAGMGGIAEVLLNEGYQVSGSDRQANGMTDRLSGLGATIFFGHQASNVEKANVVVVSSAIDPTNPEVNAANEMRIPVIRRAEMLAELMRFRHGIAIAGTHGKTTTTSLIATIFAQAELDPTFVIGGLLNSAGTNARLGSSQYLIAEADESDASFVHLQPMVSVVTNIEPDHMETYQGDFQKMQDTYIDFLHNLPFYGLAVLCIDDPVITQLLPRIKRKYLTYGYSEVADVRATHVKHTFNQSEFTLKRKDHQDIQVVVNAPGKHNVLNALAAIAVATDENIEDAAITAALANFSGIGRRFEMLGEFATGEGDVLLVDDYGHHPTEVEATIAVARNNWPDRRLVMAYQPHRYSRTRDLYEDFVRVLSQVDVLLLLDVYSAGEEKIEGADSKSLCRSMRQRGQLEPIYVADKNELPKLLADNLKDQDILLTQGAGNIGQIAKELQEMKLDKGALRTGWSK
Cell wall formation.
Q15Q18
Q86BY9
RIG_DROME
Protein rigor mortis
Sophophora
MNSQVMYHNVPTPPGNVSLAAAAPDGGLLYAGIRCINYISAPPANGEQPQVVTMSTRINILALDVSPMWGLGNGGPTKPFAIVGDDLSVQVWDCALGEAVIGHKAHQHQHEARDVRVVHHTTNSVLMSYLANGNILSMDASDLVIYCVASNTYCRRSTFISPRNHQLTMVRCSPYNDNLFAVGTAMGNVLVCDLRKMNIVYKFHGHKAPICGLAWREVPAAEDEKTNNLALSAEEWRSRNGGQEEKPKTKPPPLTKSKAAESDDPFDIYNFDHLEYEFGAPIAERRRKSSEDCGGEFVGLEKPAGAAVLDFVEACESVKAELLASRQEDKTQHVEVTLHDCEPTKPTGPLSDASTISNKNDASDSTEGSLEVIQYSSSSDDAVIVDGEAAKPKREVLHHIYHQAEVHASGTPQTKSEPQSNLQVVPAISAETISLTSVNSTHLETLLVSIDGDEVMMIWNTNTGAHAGKNYSKSKTAGKLNNVYWLNNHVIVSLSRHQLFFWSVEFERKMLRYKISKDKSHSCHLQDIVSFACDSSKEMIWLCRNNRQIGMMNPKTGRMADFYGTVAFGVRAMAECPDDMNKIALGCSDRRVAFFDISKLTTSCLPIDSVYVSSNVYCLAWSPNCLELAFGTFDGTVGILDVERMKVKTHLRTPHKKEVYSLVWQDHFIYFIVNRVLGFFDLRKSKIEPTIVNCISRPSYLSIRDSFLFVGTDDGLLQIHERDSGMEKSWSPFIRQSALFARYVTDIAWCPLDSNKFAVSGNDRSVYVMEFQPTERNWKTLHTFTANTEKASITSMRWSHTQKHLLLTFHIEGKVCLWNCNAPEKPPLTITYHCPMWCGMFLPTNENIIMCSGKALSVELIDIKDALEGDEKSICPKVDALLNVKWASKSLTQPYAPVLTAAEKKRQRRDQRKAAAKLEVDVANKDQKKIQESVTAVIDNPTNDKCTQETPVEEMLEALSLDKEQNNRSAKECPKCKEQSPDSFTHSRTCLYLTQKELNKSALEKLAIVLTEDSAKIDKSVLISKLFSSKVMAKELIATELTNLKHSNTKDIAPLCLAMSTFKLREELEQHIANKTLTERHVSLAPSVSFTLWQDCCRAYAKQMEEKGYIMHAATYLFSQGMQSEAIKLFLANEYYKEALVHARICLPATDPLIKTVINNWLEHLEGTGNFAAAALICVLDNEMLRGYSYLRKYRNCTPEIADLMDQIKRIGQLGGVLDGCAPNEPIHNGSTAEH
Nuclear receptor cofactor for the ecdysone-regulated processes of molting and puparium formation. Acts downstream from ecdysone biosynthesis and release to control the expression of specific ecdysone-regulated genes such as Eip74EF (E74).
Q86BY9
Q9MLJ8
CYB_BUNFA
Ubiquinol-cytochrome-c reductase complex cytochrome b subunit
Bungarus
MSNQHILLMSNLLPVGSNISTWWNFGSMLLTCLLLQIMTGFFLAIHYTANINLAFSSVVHILRDVPYGWIMQNIHAIGASLFFICIYIHIARGLYYGLYLNKEVWLSGTALLITLMATAFFGYVLPWGQMSFLAATVITNLLTAIPYLGNTLTIWLWGGFSINDPTLTRFFALHFILPFAIISLSSIHIILLHNEGSNNPLGTNSDIDKIPLHPYHSYKDMLMITIMITMLFITMSFTPNLLNDPENFSKANPLLTPQHIKPEWYFLFAYGILRSIPNKLGGTMALIMSVAILITVPFTHTSHTRSMLFRPLTQILFWTLISTFIIITWTATKPVESPFISISQMTSIIYFSFFIINPLLGWIENKIMMP
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
Q9MLJ8
Q0V869
OTU11_ARATH
Deubiquitinating enzyme OTU11
Arabidopsis
MDENHRNPFANASTSARASGSTSASSNSSFSSSVADTDDDQTIARILAEDESLRREGKLGKRLSHLDSIPHTPRVNREIPDINDATLDHELLSGRLATYGLAELQMEGDGNCQFRALADQLFRNADYHKHVRKHVVKQLKQQRKLYEEYVPMKYRHYTRKMKKHGEWGDHVTLQAAADRFEAKICLVTSFRDQSYIEILPHNKNPLREAWLSFWSEVHYNSLYANGVLALPDVPTRKPRRKHWLF
Hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation (Probable). Inactive cysteine protease .
Q0V869
Q986D2
ATPF1_RHILO
F-type ATPase subunit b 1
Mesorhizobium
MFVTSAFAEETAPAVTGGDTHSGTGVPAEAHGTFPPFDPATFPSQLLWLAITFGLFYLFLKKVAMPRIGGIIDVRNDRISQDLDQASKLKGEADAAVAAYEQELAEAKKNASSIGQQAADAAKAEAETARKKIEAALDEKLGEAEARISSIKANAMKEVGSIAEDTASAIVEALVGGKASKAEIAAAVKSVAR
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
Q986D2