accession
stringlengths 6
10
| name
stringlengths 6
11
| Full Name
stringlengths 1
147
⌀ | taxon
stringlengths 3
46
⌀ | sequence
stringlengths 16
2.75k
| function
stringlengths 6
5.51k
| AlphaFoldDB
stringlengths 6
10
|
|---|---|---|---|---|---|---|
B0SFU0
|
NUOH_LEPBA
|
NDH-1 subunit H
|
Leptospira
|
MDWALILAWGIKILSLFFVILTGVAYYTLAERKFAGFIQDRPGPNRAGPFGIFQPLADGIKFIAKEEIFPKNVSKGMYLLAPTISMTCAIMAWAVIPFGGTLPAPEWLTTLTGVATIDLQIANPDSGVLYMLAISSLSVYGIMIAGWSSNNKYSLLGGVRSTAQMISYELPMGLSIVAIVIMTGSLKLTDISDSQKDMWNILSPPGFVAFFIYVTAMFAETNRLPFDLAEAESELVVGFHTEYGAFKFALFFLAEYMNMITMSCLTTLLFFGGYNVPFQLGAGSEYQAFIGLGFFILKVLFFAFLFIWVRWTLPRFRYDQLMKLGWKKMIPWGLFVVMFASIYTVYWKEGWMKLFI
|
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.
|
B0SFU0
|
Q6CLS2
|
LIPA_KLULA
|
Lipoic acid synthase
|
Kluyveromyces
|
MLKPGIRSVQKRFITETVVRSTQPSVSRRRKTTHFTDKLNKGPSFEDFVNGNAQKFTLDPLEKARQNSEEVQRLPTWLKVPIAKGSNFHKLKNDVKELKLSTVCEEAKCPNIGECWGGGDKSKATATIMLLGDTCTRGCRFCSVKTNRKPSAPDPTEPENTAEAISRWGLGYVVLTTVDRDDLVDGGAYHLAETVQKIKQKAPNILVETLSGDFRGDLEMVKVMALSGLDVYAHNMETVEALTPHVRDRRATYRQSLSVLECAKKTVPTLVTKTSVMLGLGETDEQVLQTMKDLRAIGCDVITFGQYMRPTKRHMKVVEYVTPEKFDYWKQKALELGFLYCASGPLVRSSYKAGESFIENVLRGRSRARI
|
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
|
Q6CLS2
|
A0Q8E2
|
ATPD_FRATN
|
F-type ATPase subunit delta
|
Francisella
|
MTNISVIAKPYAKAAFEFANEHNLLQQWSKLLQTFSELIKDKSVAAIVSSPTISQIEVVDALKKQLDENFFNFLALIAENKKMLIMPEIADQFESIKNIHNNVRVADVTLAYATDKNILDSLKTSLEKKFGCTIDMHINIDPAIIGGAVVKVGDTVIDSSVSGHLEKLKSILLS
|
This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
|
A0Q8E2
|
P0CN51
|
EIF3E_CRYNB
|
Eukaryotic translation initiation factor 3 subunit E
|
Cryptococcus neoformans species complex
|
MADYDLTQKLIPHLDRHLAIPLLNHLSDIAIYPAEQLARAQYDLAKGTNMVNYVEQFHAQIENAEPTDFARLRDEATAKYQELQEKAQPVTKVIEDPDAVAKLRSGGDKDRNLDLLRSEYQIDIDQINALYHFGQYQYSLGDYGSAGNLLYHFLILSPSYELNISAQWGKLASNILNGEWDAALMQVRDLRETIDNPHGTSLAKPLAQLQARTWLLHWSLFVFFNLGENQGCQGLLDMFLSPAYLNTIQTSCPHLLRYLVAAAIISRRAPKPANVRSRDHVKELTRIVETEEYQYTDPITSFLKDVFADFDLTQAQQRLSVAESVVRSDFFLSGFADEFVENARWLISEVICRLHRRIDIGQLSKTLNLSNEEGEKWIVNLIRDSRMGVEAKIDLKENMLHITRPHATPTATLIETTRGLAFRSQAIQFAMQSSVGEPRERGERGERGNKGGRGRPRTQEVAA
|
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
|
P0CN51
|
P00119
|
CYC6_EUGGR
|
Soluble cytochrome f
|
Euglena
|
GGADVFADNCSTCHVNGGNVISAGKVLSKTAIEEYLDGGYTKEAIEYQVRNGKGPMPAWEGVLSEDEIVAVTDYVYTQAGGAWANVS
|
Functions as an electron carrier between membrane-bound cytochrome b6-f and photosystem I in oxygenic photosynthesis.
|
P00119
|
B3R7A2
|
MURA_CUPTR
|
UDP-N-acetylglucosamine enolpyruvyl transferase
|
Cupriavidus
|
MDKFQIHGNGPLKGEIRVSGAKNAALPILCAGLLTADTVALDNVPNLQDVRTTLKLLRLMGMQAEFDGARVTLNGADVNVLEAPYELVKTMRASILVLGPLVARFGEARVSLPGGCGIGARPVDQHIKGLQAMGAEITIEHGFIHARAKRLKGARVVTDMITVTGTENLLMAATLAEGETVLENAAREPEVTDLAHLLVKMGAKIDGIGTDRLVVHGVERLHGASHSVIADRIEAGTFLCAAAATLGDLVLRGVQPDILDTVLDKLREAGARLETGDDWIRLAMPHRAKAVSFRTSEYPAFPTDMQAQFMALNAVAEGTARVTETIFENRFMHVQELNRLGADITVEGNTAVVNGVPRLSGANVMATDLRASASLVIAGLVADGETVIDRIYHLDRGYDRMEDKLSAVGAKIRRIA
|
Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
|
B3R7A2
|
P20900
|
PSAE_THEVL
|
p30 protein
|
Thermostichus
|
MVQRGSKVKILRPESYVYNEVGTVAS
|
Stabilizes the interaction between PsaC and the PSI core, assists the docking of the ferredoxin to PSI and interacts with ferredoxin-NADP oxidoreductase.
|
P20900
|
Q9Y6Y1
|
CMTA1_HUMAN
|
Calmodulin-binding transcription activator 1
|
Homo
|
MWRAEGKWLPKTSRKSVSQSVFCGTSTYCVLNTVPPIEDDHGNSNSSHVKIFLPKKLLECLPKCSSLPKERHRWNTNEEIAAYLITFEKHEEWLTTSPKTRPQNGSMILYNRKKVKYRKDGYCWKKRKDGKTTREDHMKLKVQGVECLYGCYVHSSIIPTFHRRCYWLLQNPDIVLVHYLNVPAIEDCGKPCGPILCSINTDKKEWAKWTKEELIGQLKPMFHGIKWTCSNGNSSSGFSVEQLVQQILDSHQTKPQPRTHNCLCTGSLGAGGSVHHKCNSAKHRIISPKVEPRTGGYGSHSEVQHNDVSEGKHEHSHSKGSSREKRNGKVAKPVLLHQSSTEVSSTNQVEVPDTTQSSPVSISSGLNSDPDMVDSPVVTGVSGMAVASVMGSLSQSATVFMSEVTNEAVYTMSPTAGPNHHLLSPDASQGLVLAVSSDGHKFAFPTTGSSESLSMLPTNVSEELVLSTTLDGGRKIPETTMNFDPDCFLNNPKQGQTYGGGGLKAEMVSSNIRHSPPGERSFSFTTVLTKEIKTEDTSFEQQMAKEAYSSSAAAVAASSLTLTAGSSLLPSGGGLSPSTTLEQMDFSAIDSNKDYTSSFSQTGHSPHIHQTPSPSFFLQDASKPLPVEQNTHSSLSDSGGTFVMPTVKTEASSQTSSCSGHVETRIESTSSLHLMQFQANFQAMTAEGEVTMETSQAAEGSEVLLKSGELQACSSEHYLQPETNGVIRSAGGVPILPGNVVQGLYPVAQPSLGNASNMELSLDHFDISFSNQFSDLINDFISVEGGSSTIYGHQLVSGDSTALSQSEDGARAPFTQAEMCLPCCSPQQGSLQLSSSEGGASTMAYMHVAEVVSAASAQGTLGMLQQSGRVFMVTDYSPEWSYPEGGVKVLITGPWQEASNNYSCLFDQISVPASLIQPGVLRCYCPAHDTGLVTLQVAFNNQIISNSVVFEYKARALPTLPSSQHDWLSLDDNQFRMSILERLEQMERRMAEMTGSQQHKQASGGGSSGGGSGSGNGGSQAQCASGTGALGSCFESRVVVVCEKMMSRACWAKSKHLIHSKTFRGMTLLHLAAAQGYATLIQTLIKWRTKHADSIDLELEVDPLNVDHFSCTPLMWACALGHLEAAVVLYKWDRRAISIPDSLGRLPLGIARSRGHVKLAECLEHLQRDEQAQLGQNPRIHCPASEEPSTESWMAQWHSEAISSPEIPKGVTVIASTNPELRRPRSEPSNYYSSESHKDYPAPKKHKLNPEYFQTRQEKLLPTALSLEEPNIRKQSPSSKQSVPETLSPSEGVRDFSRELSPPTPETAAFQASGSQPVGKWNSKDLYIGVSTVQVTGNPKGTSVGKEAAPSQVRPREPMSVLMMANREVVNTELGSYRDSAENEECGQPMDDIQVNMMTLAEHIIEATPDRIKQENFVPMESSGLERTDPATISSTMSWLASYLADADCLPSAAQIRSAYNEPLTPSSNTSLSPVGSPVSEIAFEKPNLPSAADWSEFLSASTSEKVENEFAQLTLSDHEQRELYEAARLVQTAFRKYKGRPLREQQEVAAAVIQRCYRKYKQYALYKKMTQAAILIQSKFRSYYEQKKFQQSRRAAVLIQKYYRSYKKCGKRRQARRTAVIVQQKLRSSLLTKKQDQAARKIMRFLRRCRHSPLVDHRLYKRSERIEKGQGT
|
Transcriptional activator.
|
Q9Y6Y1
|
Q7XDQ7
|
PIRL8_ORYSJ
|
Intracellular Ras-group-related LRR protein 8
|
Oryza sativa
|
MESSPPPPPPTITVQVKFGGRTIPVEVPAAATAADLKRLLQPLTNVLPRGQRLICKGKVLADAASLSSMQVVNGSKVMLMASQGLHQGDGPITKNSSVPAPSTRRASNVKEAQIQKSDTNVSKIRPERWKATGIIALSDSSLKAVPEEVWGCGSSIRVLDVSNNCIEAIPQEIAALRSLQKLILTANDIADGNISWEGLTCVQTLTVLSLSQNRLVTLPSSLGSITHLRELRIANNRLENLPVEIGLLKHLEILIANNNRITSLPSSIGGCESLNEVDLSSNLLAELPEAFGNLQHLKALSVRNNGLTSLPSAFFIKCSQLITLDLHGTEITNDVLRQVDGWEEFDERRRKKHQKQLDFRVGSSVVFDEGADDDYRRL
|
Leucine-rich repeat protein that likely mediates protein interactions, possibly in the context of signal transduction.
|
Q7XDQ7
|
B2K767
|
PYRC_YERPB
|
Dihydroorotase
|
Yersinia
|
MTAQPQTLKIRRPDDWHIHLRDDEMLSTVLPYTSEVFARAIVMPNLAQPITTVASAIAYRERILAAVPAGHKFTPLMTCYLTNSLDVKELTTGFEQGVFTAAKLYPANATTNSTHGVSDIPAIYPLFEQMQKIGMPLLIHGEVTDAAVDIFDREARFIDQILEPIRQKFPELKIVFEHITTKDAADYVLAGNRFLGATVTPQHLMFNRNHMLVGGIRPHLFCLPILKRSTHQQALRAAVASGSDRFFLGTDSAPHAKHRKESSCGCAGVFNAPAALPAYASVFEELNALQHLEAFCALNGPRFYGLPVNDDVVELVRTPFLQPEEIPLGNESVIPFLAGQTLNWSVKR
|
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
|
B2K767
|
Q7TU07
|
TRUA_RHOBA
|
tRNA-uridine isomerase I
|
Rhodopirellula
|
MQANDRPRTFHLTVAYDGTEYCGWQVQPEQRSIQSELERVIRPLAGRPVRVLGSGRTDAGVHAIGQVARCVLPVWKADTVALQRAINSKLPNDIRVKAVRETRERFHPIADATGKQYQYLVQVGGSRDPFANRFVNRVGGPIDHSAMQSAAAKFVGRHDFKAFQGTGAERPSTVRTIHSARWIPRVATGPTGAELEGEHWCFEIDGEGFLYNMVRNLMGTMLEVGRGKKSPNWIDEVLASRDRKMAGPTAPPQGLFLCRVDYPDEVFQVEEPDVIE
|
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
|
Q7TU07
|
A1DGY9
|
MTLD_NEOFI
|
Mannitol-1-phosphate 5-dehydrogenase
|
Aspergillus subgen. Fumigati
|
MGKKAIQFGGGNIGRGFVAEFLHEAGYEVVFIDVVDKIIDALKSTPSYEVSEVSEEGEKTKTITNYRAINSKTNEEDVVKEIGTADVVTCAVGPNVLKFIAPVIAKGIDARTASKPVAVIACENAIGATDTLRGFIEQHTDKDRLSSMSERARFANSAIDRIVPNQPPNAGLNVRIEKFYEWTVEQTPFGEFGHPDIPAIHWVDDLKPYIERKLFTVNTGHATTAYYGHVRGKKMIADALADAEIRKIVHNVLEQTAMLITTKHEITEQEQNEYVDTIVKRMSNPFLEDNVERVGRAPLRKLSRNERFIGPASQLAEKGLPFDALLGSIEMALRFQNVPGDEESAELAKILKEMSADEATGKLTGLEKSHPLYKPVQNVVAKVQKDSK
|
Catalyzes the NAD(H)-dependent interconversion of D-fructose 6-phosphate and D-mannitol 1-phosphate in the mannitol metabolic pathway.
|
A1DGY9
|
P0CF26
|
INSB2_ECOLI
|
IS1b
|
Escherichia
|
MPGNRPHYGRWPQHDFPPFKKLRPQSVTSRIQPGSDVIVCAEMDEQWGYVGAKSRQRWLFYAYDRLRKTVVAHVFGERTMATLGRLMSLLSPFDVVIWMTDGWPLYESRLKGKLHVISKRYTQRIERHNLNLRQHLARLGRKSLSFSKSVEQHDKVIGHYLNIKHYQ
|
Absolutely required for transposition of IS1.
|
P0CF26
|
P23763
|
VAMP1_HUMAN
|
Synaptobrevin-1
|
Homo
|
MSAPAQPPAEGTEGTAPGGGPPGPPPNMTSNRRLQQTQAQVEEVVDIIRVNVDKVLERDQKLSELDDRADALQAGASQFESSAAKLKRKYWWKNCKMMIMLGAICAIIVVVIVIYFFT
|
Involved in the targeting and/or fusion of transport vesicles to their target membrane.
|
P23763
|
B4TBX8
|
RHAM_SALHS
|
Type-3 mutarotase
|
Salmonella
|
MIRKAFVMQVNADAHEEYQRRHNPIWPELEAVLKSHGAHHYAIYLDQERNLLFATVEIESEERWNAVASTDVCQRWWKHMRDVMPANPDNSPVNAELKEVFYLQ
|
Involved in the anomeric conversion of L-rhamnose.
|
B4TBX8
|
Q5ZIB9
|
ANM7_CHICK
|
[Myelin basic protein]-arginine N-methyltransferase PRMT7
|
Gallus
|
MKTFCGRANPTTGSLEWVEEDEDYDYHQEIARSRYADMLHDKDRNMKYYQGIRAAVSRVKGRGEKAIVLDIGTGTGLLSMMAASAGADFCYAVEVFKPMANAAVKIVEKNGFGDKIKVINKHSTEVTVGPDGDMQCRANILVTELFDTELIGEGALPTYEHAHKYLVQEGCEAVPHRATVYVQLVESKRMWSWNKLFPVHVEAEDGEKIIVSPSEMENCPGVPSVCDIQLNQMPSSDFTILSDVVTMFSVDFSKPVRSASTCYRAQLDPVKSGKAQIVLSWWDIDMDPSGTINCTMAPYWVKPMSAFQWRDHWMQCVYFLPKEEQVLQGEKVHLTACRDEYSVWYTLQKAREEDESKADARVESPVCRCQAHLLWNRPRFGELNDQNRTRQYIKSLMSVLRTDSVCLCISDGSLLPVLAHYLGAEQVFTLENSAVSCSVMKKFFKANHLEDKIKIVEARPELLTSSHLEEKKISVLVGEPFFTTSLLPWHNLYFWYARTAVTEHLASDVTVLPQSAALHMMIVEFQDLWRIRSPCGTCEGFDVQTMDDMIKNSLNFRESKEAEPHPLWEYPCKSLSNPQEVLLFDFRKTVPQHCLSTEGSVNLLRKGKSHGAVLWMEYHLTADISVSTGLMQISNEKGNCEWNPHCKQAVYFFSSVIESETLADVPTAVTYAIKFDTKTGEIAMDFKLL
|
Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo.
|
Q5ZIB9
|
Q92203
|
KAPS_EMENI
|
Adenosine-5'-phosphosulfate kinase
|
Aspergillus subgen. Nidulantes
|
MATNITHHAGITRNERNQLRKQKGLTIWLTGLSASGKSTIAVELEHQLLQRGLHAYRLDGDNVRFGLNKDLGFSDADRNENIRRIAEVAKLFADSSSIAITSFISPFRADRDTARKLHEVPTPNDSTGLPFVEVFVDVPIEVAEKRDPKGLYKKAREGIIKEFTGISSPYEAPENPEVHVKNVDLPIQEAVKQIIDYLDSKKLLDA
|
Catalyzes the synthesis of activated sulfate.
|
Q92203
|
Q8LCH9
|
TRL33_ARATH
|
Thioredoxin-like 3-3
|
Arabidopsis
|
MRKQESEGANLEFESKSNDNGNVKIAPNDQSFLTILDDIKSSKSPAVINYGASWCGVCSQILPAFRKLSNSFSKLKFVYADIDECPETTRHIRYTPTFQFYRDGEKVDEMFGAGEQRLHDRLWLHS
|
Probable thiol-disulfide oxidoreductase that may participate in various redox reactions.
|
Q8LCH9
|
Q9IA02
|
FZD9_CHICK
|
Frizzled-9
|
Gallus
|
ACDNPEKFQYVEKSLSCAPRCSPGVDVYWSREDKDFAFVWMAVWSTLCFVSTAFTVLTFLLDPHRFQYPERPIIFLSMCYNVYSVAFIIRSVAGAETIACDRENGELYIIQEGLESTGCTIVFLILYYFGMASSLWWVVLTLTWFLAAGKKWGHEAIEAHSSYFHMAAWGIPAMKTIVILTMRKVAGDELTGLCYVGSMDVSALTGFVLIPLSCYLVVGTSFILTGFVALFHIRKIMKTGGTNTEKLEKLMVKIGVFSILYTVPATCVIVCYFYERLNVDYWNLRALERACVPLPGRRAADCSLEASVPTVAVFMLKIFMSLVVGITSGVWVWSSKTLQTWQSLCNRKLGVRTRGKPCSGVSCGGVHCHYKAPTVMLHMTKTDPYLDNPTHV
|
Receptor for WNT2 that is coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes.
|
Q9IA02
|
Q4ZNI9
|
RF3_PSEU2
|
Peptide chain release factor 3
|
Pseudomonas syringae
|
MTQQAAEVAKRRTFAIISHPDAGKTTITEKLLLMGKAISVAGTVKSRKSDRHATSDWMEMEKQRGISITTSVMQFPYRDHMINLLDTPGHEDFSEDTYRTLTAVDSALMVLDGGKGVEPRTIALMDVCRLRDTPIVSFINKLDRDIRDPIELLDEIEAVLKIKAAPITWPIGCYRDFKGVYHLADDYIIVYTAGHGHERTETKIIEKLDSDEARAHLGDEYERFVEQLELVQGACHEFNQQEFIDGQLTPVFFGTALGNFGVDHVLDAVVNWAPKPLARVANERTVEPAEEKFSGFVFKIQANMDPKHRDRIAFMRICSGRYDKGMKMRHVRLGKDVRIGDALTFFSSEREQLEEAYAGDIIGLHNHGTIQIGDTFTEGEALGFTGIPHFAPELFRRVRLKDPLKSKQLRQGLQQLAEEGATQVFFPQRSNDIILGAVGVLQFDVVASRLKEEYKVECAYEPITVWSARWIDCDDKKKLEEFENKAVENLAVDGGGHLTYLAPTRVNLALMEERWPDVKFRATREHH
|
Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.
|
Q4ZNI9
|
A4W5M3
|
KDGT_ENT38
|
2-keto-3-deoxygluconate permease
|
Enterobacter
|
MKIKATIERIPGGMMLVPLVLGAILNTLAPNTGAYFGGFTKGMISGTVPILAVWFFCIGASINLRATGTVLRKSGTLVLTKIAVAWVVAMGCAMFIPENGIQTGFFAGLSVLAIVSAMDMTNGGLYASLMNQYGTKEESGAFVLMSLESGPLVTMLILGSAGLASFEPHHFVGAVLPFLIGFALGNLDTDLRDFFSKATPVLIPFFGFALGNTINLNVIMDTGLLGIVLGVAVIIITGIPLIIADRVIGGGNGTAGVAASSAAGAAVANPMIIAQINPSFEPVAASATALVAASVIVTAILVPIITALYAKRYGNIPKADVEPQPVESLHH
|
Catalyzes the proton-dependent uptake of 2-keto-3-deoxygluconate (KDG) into the cell.
|
A4W5M3
|
Q8H0V4
|
DUF7_ARATH
|
ABAP1-interacting protein 1
|
Arabidopsis
|
MLLTTGRKEKLSVSKGSEIEISSQEYEYGSGNVWYCVILEENLAKSKRKKLSVRHLDPLLKYDYSPPLIKTTVHRFMRPVPPPDPFPEVDFEEGDVVDAAYKGGWCSGSVVKVLGNRRFLVYLRFQPDVIELLRKDLRPHFVWKDEEWFRCEKQQLIESDFSAGKSVEVRTKVDKLGDVWAPAMVIKEDEDGTMLVKLKTLKEEEVNCTKISVSYSEIRPSPLPIGLRDYKLMENVDALVESGWCPGVVSKVLAGKRYAVDLGPNRESKEFSRLQLRPSIEWKDGIWHRKEKVSGSEESSHAVEETAASTRIRITVRTALKEKKALGTGINVRTTRSSSGAMHNPLPASFNGGDVAEAGRVSVTVNETPLFETAALSGELGNSLADVVMNESAPVTSQPEIAAPKEFHPSVVLGVAAAVKTQGKTTPKKKLQAMKNQKSSTNDSVGEKVSVNKRKRGQPRKFIVAEPKQKIGVSGNNSKAATIEHADMTDDDRPLASWVHTGNSSSGQSVSRTPDIGLNTVVEKHVDIVETPPGRESTMVLPFVKKSQLWKVLESMEVFKVVPQSPHFSPLLESEEECREGDAIGRMVMFSSLLEKVNNLQVDDPISSINRIDECFLKLEKHGFNVTTPRSRIAKILSIKERQTCALEELKAVEEKITENDNKRRKYEEDIVELQRQEVLMKEAKVTLDNEIARMQSQAAVLDQEVQNVDHEFQAILAAPWK
|
May act as a link between DNA replication, transcription and chromatin remodeling during flower development. May participate in the repression of LHP1-targeted genes during flower development by direct interaction with LHP1 . May be involved in the polar growth of plant cells via transportation of RNAs (Probable).
|
Q8H0V4
|
A3N186
|
METK_ACTP2
|
Methionine adenosyltransferase
|
Actinobacillus
|
MAINLFTSESVSEGHPDKIADQISDAVLDEILKQDPKARVACETYVKTGMALVGGEITTSAWVDIENLTRQVICDIGYTHSDMGFDAHSCAVLNAIGKQSPDINQGVDRADPLEQGAGDQGIMFGYATNETDVLMPAPITYAHRLMEQQAKVRKSGKLDWLRPDAKSQLTFAYENNKIVGIDAVVLSTQHAEHVSQKDLVEGVMEEIIKPVLPSEWLSQNTKYFINPTGRFVIGGPMGDCGLTGRKIIVDTYGGAARHGGGAFSGKDPSKVDRSAAYAARYVAKNIVAAGLADRCEIQLSYAIGVADPTSIMVETFGTGRVSNETLVKLIYQNFDLRPYGLIKMLDLIQPIYRETAAYGHFGREHFPWEQTDKAEALRAGAGL
|
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
|
A3N186
|
Q9WX57
|
MAIA_GEOSE
|
Maleate cis-trans isomerase
|
Geobacillus
|
MAKHFRIGMIVPSSNTTMETEIPAMLQSRMKEIPEETFTFHSSRMRMMHVTKEELKKMDEESDRCAIELSDARCDVLAYACLVAIMCQGPGYHEKSEARLASLTAQNGGAAPVISSAGALIDGIRTLGAKKIALIAPYMKPLTNQVIEYITASGIEVTDSISLEIPDNLEVGRQDPMRLIEIVKNLDVSNADAVVLSACVQMPSLPAIQKVQDQLGLPVLSAATSTVYKILKSLNLKTYVPNAGSLLSGKY
|
Catalyzes cis-trans isomerization of the C2-C3 double bond in maleate to yield fumarate.
|
Q9WX57
|
Q8NGI4
|
OR4DB_HUMAN
|
Olfactory receptor 4D11
|
Homo
|
MELGNVTRVKEFIFLGLTQSQDQSLVLFLFLCLVYMTTLLGNLLIMVTVTCESRLHTPMYFLLRNLAILDICFSSTTAPKVLLDLLSKKKTISYTSCMTQIFLFHLLGGADIFSLSVMAFDCYMAISKPLHYVTIMSRGQCTALISASWMGGFVHSIVQISLLLPLPFCGPNVLDTFYCDVPQVLKLTCTDTFALEFLMISNNGLVTTLWFIFLLVSYTVILMTLRSQAGGGRRKAISTCTSHITVVTLHFVPCIYVYARPFTALPTEKAISVTFTVISPLLNPLIYTLRNQEMKSAMRRLKRRLVPSERE
|
Odorant receptor.
|
Q8NGI4
|
Q9FIF7
|
PP435_ARATH
|
Protein ORGANELLE TRANSCRIPT PROCESSING 80
|
Arabidopsis
|
MISSLAAITGGPSTFRRDPDSNTLRLSRRKTLISVLRSCKNIAHVPSIHAKIIRTFHDQDAFVVFELIRVCSTLDSVDYAYDVFSYVSNPNVYLYTAMIDGFVSSGRSADGVSLYHRMIHNSVLPDNYVITSVLKACDLKVCREIHAQVLKLGFGSSRSVGLKMMEIYGKSGELVNAKKMFDEMPDRDHVAATVMINCYSECGFIKEALELFQDVKIKDTVCWTAMIDGLVRNKEMNKALELFREMQMENVSANEFTAVCVLSACSDLGALELGRWVHSFVENQRMELSNFVGNALINMYSRCGDINEARRVFRVMRDKDVISYNTMISGLAMHGASVEAINEFRDMVNRGFRPNQVTLVALLNACSHGGLLDIGLEVFNSMKRVFNVEPQIEHYGCIVDLLGRVGRLEEAYRFIENIPIEPDHIMLGTLLSACKIHGNMELGEKIAKRLFESENPDSGTYVLLSNLYASSGKWKESTEIRESMRDSGIEKEPGCSTIEVDNQIHEFLVGDIAHPHKEAIYQRLQELNRILRFKENQIDIIMGF
|
Involved in RNA editing event in chloroplasts. Required for the editing of a single site in rpl23 transcript.
|
Q9FIF7
|
A9L0V0
|
RLMG_SHEB9
|
rRNA (guanine-N(2)-)-methyltransferase RlmG
|
Shewanella
|
MTTQFSVAGVELELLRYPAQQESNLQAWDAADEHLLKSLIESEQAAVPTAIINDSFGALSCGVSKLNPSWPLCVETDARTSFLGTEQNHGRNQLPLDNLQWFTSRDTLPENLALVLMKLPKNLSYFAHQLTRLSQVLPAGTRVLVAAKAKSINGALLDIFAKHLGPASASLAWKNTRVITCVSDGKPRPLAKEVTWTVPEYQLEISNLSNVFAANKLDIGARIMLENLPKGDFKSIVDLGCGNGVLGLRTAQLFPEADIHFIDDSEMAVASAKANWARNQLPADKGHFYWDDCMTHLPEEVQPDLVLCNPPFHQGEAITDHIAWQMFLDARRRLKDGGILHIVGNRHLAYHVKLQRLFKNCTTVASNGKFVILQAQKK
|
Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA.
|
A9L0V0
|
Q8YY90
|
MOBA_NOSS1
|
Molybdopterin-guanine dinucleotide synthase
|
Nostoc
|
MNNLTAIVLAGGQSSRMGQDKALITVQGVPLLQFVCNIAASCADTVYIVTPWPERYEHLFLPGCKFLPEAATQGPLIGFAQGLAEVKSEWVLLLACDLPKLRVEVLQEWAANLDSVPEEAIAALPHHAKGWEPLCGFYRRRCLPQLLEFIHQGGRSFQQWLQHHSVQVLSLPTPEILFNCNTPEDLAVIQGEFDDLSPNPSPTRRGA
|
Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.
|
Q8YY90
|
A6TVD3
|
PFKA_ALKMQ
|
Phosphohexokinase
|
Alkaliphilus
|
MKTIGVLTSGGDSPGMNAAIRAVVRSGIYNGCKIMGIKQGYSGLINAKIEEMNLSSVADIIHRGGTILRTARCEEFRTEEGRKKALNVLKVLKIDGVVVIGGDGSFQGAKKLSELGIPTVAVPGTIDNDLGYSDYTIGFDTAMNTVLDAISKIRDTSTSHGRANIIEVMGRHCGDIALYTGLAGGAESIIIPEVGLDIDEICRKLLQGKNRGKLHSLIVLAEGVGGAIDLGKIIEEKTGIETRSTVFGHIQRGGSPTAFDRILASKMGARAVDLLIEEKGNRAVGIKGNQIFDMDIEEALNIENKFDQETFELAKILSI
|
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
|
A6TVD3
|
B7LUZ9
|
RECO_ESCF3
|
Recombination protein O
|
Escherichia
|
MEGWQRAFVLHSRPWSETSLMLDVFTEESGRVRLVAKGARSKRSTLKGALQPFTPLLLRFGGRGEVKTLRSAEAVSLALPLSGITLYSGLYINELLSRVLEYETRFSELFFDYLHCIQSLAGATGTPEPALRRFELALLGHLGYGVNFTHCAGSGEPVDDTMTYRYREEKGFIASVVIDNKTFTGRQLKALNAREFPDADTLRAAKRFTRMALKPYLGGKPLKSRELFRQFMPKRTVKTHYE
|
Involved in DNA repair and RecF pathway recombination.
|
B7LUZ9
|
Q00420
|
GABP1_MOUSE
|
GABP subunit beta-2
|
Mus
|
MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHFSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHANIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGGVVNLTDETGVSAVQFGNSSTSVLATLAALAEASAPLSNSSETPVVATEEVVTAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLHSIPTSGMGQPIIVTMPDGQQVLTVPATDIAEETVISEEPPAKRQCMEIIESRVECAEIEEREALQKQLDEANREAQKYRQQLLKKEQEAEAYRQKLEAMTRIQTNKEAV
|
Transcription factor capable of interacting with purine rich repeats (GA repeats) . Acts as a a master regulator of nuclear-encoded mitochondrial genes .
|
Q00420
|
A3PU84
|
MSHA_MYCSJ
|
N-acetylglucosamine-inositol-phosphate N-acetylglucosaminyltransferase
|
unclassified Mycobacterium
|
MRLATDQLGRPPQRVAVLSVHTSPLAQPGTGDAGGMNVYVLQSALHMARRGVEVEIFTRATTSADPPVVRVAPGVLVRNVVAGPFEGLDKYDLPTQLCAFTAGVLRAEATHEPGYYDIVHSHYWLSGQVGWLARDRWAVPLVHTAHTLAAVKNAALAEGDSPEPPLRAVGEQQVVDEADRLIVNTELEAEQLVSLHNADPSRIDVVHPGVDLDTFTPGDQAAARAALGLDPRETVVAFVGRIQPLKAPDILLRAAAKLPDVRVLVAGGPSGSGLAAPDNLVALADELGISERVTFLPPQSREDLVRVYRAADLVAVPSYSESFGLVAVEAQACGTPVVAAAVGGLPVAVRDGVTGALVDGHDVGDWAHTIDSLLSRGPATMRRAAVEHAATFSWAHTVDDLLASYGRAISDYRDRHPHADETLSRRTARRFSRRRGVRA
|
Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway.
|
A3PU84
|
B7LE10
|
OPGB_ECO55
|
Phosphatidylglycerol--membrane-oligosaccharide glycerophosphotransferase
|
Escherichia
|
MSELLSFALFLASVLIYAWKAGRNTWWFAATLTVLGLFVVLNITLFASDYFTGDGINDAVLYTLTNSLTGAGVSKYILPGIGIVLGLTAVFGALGWILRRRRHHPHHFGYSLLALLLALGSVDASPAFRQITELVKSQSRDGDPDFAAYYKEPSKTIPDPKLNLVYIYGESLERTYFDNEAFPDLTPELGALKNEGLDFSHTQQLPGTDYTIAGMVASQCGIPLFAPFEGNASASVSSFFPQNICLGDILKNSGYQNYFVQGANLRFAGKDVFLKSHGFDHLYGSEELKSVVADPHYRNDWGFYDDTVLDEAWKKFEELSRSSQRFSLFTLTVDTHHPDGFISRTCNRKKYDFDGKPNQSFSAVSCSQENIAAFINKIKASPWFKDTVIVVSSDHLAMNNTAWKYLNKQDRNNLFFVIRGDKPQQETLAVKRNTMDNGATVLDILGGDNYLGLGRSSLSGQSMSEIFLNIKEKTLAWKPDIIRLWKFPKEMKEFTIDQQKNMIAFSGSHFRLPLLLRVSDKRVEPLPESEYSAPLRFQLADFAPRDNFVWVDRCYKMAQLWAPELALSTDWCVSQGQLGGQQIVQHVDKTTWQGKTAFKDTVIDMARYKGNVDTLKIVDNDIRYKADSFIFNVAGAPEEVKQFSGISRPESWGRWSNAQLGDEVKIEYKHPLPKKFDLVITAKAYGNNASRPIPVRVGNEEQTLVLGNEVTTTTLHFDNPTDADTLVIVPPEPVSTNEGNILGHSPRKLGIGMVEIKVVEREG
|
Transfers a phosphoglycerol residue from phosphatidylglycerol to the membrane-bound nascent glucan backbones.
|
B7LE10
|
P93798
|
SNAA_VITVI
|
N-ethylmaleimide-sensitive factor attachment protein alpha
|
Vitis
|
MADNIQRGEEFEKKAEKKISGWGLFGSKYEDAADFYDKAANCFKLAKSWDRAGSTYVKLSTVIQSSDSKHEAAQAYADAGHCYKKTSAKEAISCLEQAAYLFLDNGRFNMAGKYYKEIAELYELEQNFEQAIIYFEKAADIYQSEEATTAANQCNAKVAQFAAQLEQYQKAIQIYEDIGRPSLNNNLLKYGVKGHLLNAGICQLCKGDVVAITNALDRYQEMDPTFSGTREYKLLVDLAAAVDEEDVVKFTDAVKEFDSMTQLDAWKTTLLLRVKEAIKAKELEEDDLT
|
Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.
|
P93798
|
A0M583
|
RL6_GRAFK
|
50S ribosomal protein L6
|
Gramella
|
MSRIGKSPVTIPEGVTVDHKDGVVTVKGKLGELKQEIRDIDVKIEDNVITFERSSEKSDQKAKHGLYRALVNNMIEGVTNGYTKSLELVGVGYRATNQGNKLDLAVGYSHNIVLDLAPEVKVETISEKGKNPIVKVTSHDKQLVGQVAAKIRSFRAPEPYKGKGIKFVGEQLRRKAGKSA
|
This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
|
A0M583
|
Q9LK73
|
U88A1_ARATH
|
UDP-glycosyltransferase 88A1
|
Arabidopsis
|
MGEEAIVLYPAPPIGHLVSMVELGKTILSKNPSLSIHIILVPPPYQPESTATYISSVSSSFPSITFHHLPAVTPYSSSSTSRHHHESLLLEILCFSNPSVHRTLFSLSRNFNVRAMIIDFFCTAVLDITADFTFPVYFFYTSGAACLAFSFYLPTIDETTPGKNLKDIPTVHIPGVPPMKGSDMPKAVLERDDEVYDVFIMFGKQLSKSSGIIINTFDALENRAIKAITEELCFRNIYPIGPLIVNGRIEDRNDNKAVSCLNWLDSQPEKSVVFLCFGSLGLFSKEQVIEIAVGLEKSGQRFLWVVRNPPELEKTELDLKSLLPEGFLSRTEDKGMVVKSWAPQVPVLNHKAVGGFVTHCGWNSILEAVCAGVPMVAWPLYAEQRFNRVMIVDEIKIAISMNESETGFVSSTEVEKRVQEIIGECPVRERTMAMKNAAELALTETGSSHTALTTLLQSWSPK
|
Possesses low quercetin 3-O-glucosyltransferase, 7-O-glucosyltransferase, 3'-O-glucosyltransferase and 4'-O-glucosyltransferase activities in vitro.
|
Q9LK73
|
Q9BQY4
|
RHXF2_HUMAN
|
Testis homeobox gene 1
|
Homo
|
MEPPDQCSQYMTSLLSPAVDDEKELQDMNAMVLSLTEEVKEEEEDAQPEPEQGTAAGEKLKSAGAQGGEEKDGGGEEKDGGGAGVPGHLWEGDLEGTSGSDGNVEDSDQSEKEPGQQYSRPQGAVGGLEPGNAQQPNVHAFTPLQLQELERIFQREQFPSEFLRRRLARSMNVTELAVQIWFENRRAKWRRHQRALMARNMLPFMAVGQPVMVTAAEAITAPLFISGMRDDYFWDHSHSSSLCFPMPPFPPPSLPLPLMLLPPMPPAGQAEFGPFPFVIVPSFTFPNV
|
Transcription factor maybe involved in reproductive processes. Modulates expression of target genes encoding proteins involved in processes relevant to spermatogenesis.
|
Q9BQY4
|
A6WL14
|
RLMM_SHEB8
|
23S rRNA 2'-O-ribose methyltransferase RlmM
|
Shewanella
|
MKNLFLFCRAGFEKECAAEIQQRAGELNVGGFVKANNNDAYVVYQCFEDDAADTLVKQLPLDSLIFARQMFAASDLLVDLPENDRISPIVAALSDVSKAGEVRVETPDTNEAKELSAFCRKFTVPLRQHLKKSGSLLAQENPKRPIIHVCFIGPGRAYVGYSYSNNSSPHFMGIPRLKMAADAPSRSSLKLDEAFGQFVPKEEQEERIRSGMNSVDLGACPGGWTYQLVRRGMFVSAVDNGPMDEKLMETGQVKHYREDGFRFEPQRKNIYWLVCDMVEKPARVAELIEAWAINGWFKEAIFNLKLPMKSRYKEVTAILETMQTILKENGVSDFKVQCKHLYHDRDEVTVHLWLRPNTAWN
|
Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA.
|
A6WL14
|
A9BBW6
|
KAIB_PROM4
|
Circadian clock protein KaiB
|
Prochlorococcus
|
MSPRKTYILKLYVAGNTPNSMRALKTLHEILENEFKGVYALKVIDILKSPQLAEEDKILATPTLTKILPPPVRRIIGDLSDRERVLIGLDLLYEELSGNEFLSSIASPNSDEDN
|
Probable component of the KaiBC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. In the complex, it may affect the phosphorylation status of KaiC.
|
A9BBW6
|
Q0K9I2
|
SSUB_CUPNH
|
Aliphatic sulfonates import ATP-binding protein SsuB
|
Cupriavidus
|
MQMYPVEQAALVELEAGLARREAAQPAAEAPRKAGGVALHVRQVVKRYDGREVLHNVALDVAPGEFLAIVGRSGCGKSTLLRLVAGLEAADGGSITVDGESAAKGRARHADVRVMFQDARLLPWKRVLDNVALGLPRTRRGEAADVLAQVGLADRAREWPARLSGGQRQRVALARALVHHPQLLLLDEPLGALDALTRIEMQGLIESLWRRLGFTALLVTHDVSEAVALADRIVLIEDGRIAMDERVALARPRERGAAGFAQLEAAVLKRVMRQAPQAQVPSHAGAHADPAATTAPLNVSWAA
|
Part of the ABC transporter complex SsuABC involved in aliphatic sulfonates import. Responsible for energy coupling to the transport system.
|
Q0K9I2
|
A1SE35
|
NUOI_NOCSJ
|
NDH-1 subunit I
|
Nocardioides
|
MAGSPEPKSMREQFWDPIAGFGVTFRTMFKKVVTEQYPFDKYPTAPRFHGRHQLNRWPDGLEKCVGCELCAWACPADAIYVEGASNSDDPDGGERFSPGERYGRVYQINYLRCILCGLCIEACPTRALTMTNEYELADDNRADLIYEKSDLLAPLLPGMEQPPHPMRLGDDEGAYYRGEFAAPAPTAPGSSTEAGA
|
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
|
A1SE35
|
Q92HF9
|
RECO_RICCN
|
Recombination protein O
|
spotted fever group
|
MNIKDIGVIIAKKPLKENTFIITVFTKNHGLYSGVVKEFSKKSKFIYQEGNIIDFLWQARLHEHIGMAKCELIKSYTGYFITNKAKLYAFNSVISLIKELFHEREEHSKFFSFLINYLDNLSKNFCFRDYINFELALLAETGYKLDLTKCGVSHVTTDLIYVSPKSARALSYEVGKPYKDKLLMLPRFLLSDNSEITLEEKRQALALTNYFFNRYLFHNNRQVEARQTFIEYTLNNF
|
Involved in DNA repair and RecF pathway recombination.
|
Q92HF9
|
B2VF76
|
RNPH_ERWT9
|
tRNA nucleotidyltransferase
|
Erwinia
|
MRPSGRSAQQVRPVTLTRHYTKHAEGSVLVEFGDTKVLCTATIEEGVPRFLKGKGQGWVTAEYGMLPRATHSRNAREAAKGKQGGRTLEIQRLIARSLRAAIDLKVLGEFTITLDCDVLQADGGTRTASITGACVALADALNHLVSTGKLKANPMKGMVAAISVGIVNGEALCDLEYVEDAAAETDMNVVMTEDGRMIEVQGTAEGEPFSHEELLKLLELARGGIDTLVAAQKAALTD
|
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
|
B2VF76
|
Q8DA68
|
AZOR_VIBVU
|
FMN-dependent NADH-azoreductase
|
Vibrio
|
MSRLLVLKSSILGDYSQSNKLVDEFINHFDHQQLVVRDLAQQPLPVLDFQVATALRAAGELTAEQQAIVTLSDTLIDEIKEADTLVIAAPMYNFTIPTQLKNWIDLIARAGVTFTYTEQGPKGLIEGKKAVIVTTRGGIHKDAASDIITPYLKTVLGFVGITEVEFVYAEALNMGDDFANKGLASASEHLAALTA
|
Also exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
|
Q8DA68
|
Q187T6
|
MUTS_CLOD6
|
DNA mismatch repair protein MutS
|
Clostridioides
|
MQIDMNKLTPMMKQYLEVKNRYKDCILFFRLGDFYEMFFEDALVASKALEIALTGKACGLEERAPMCGVPFHSANSYISKLVENGYKVAIGEQMEDPSTAKGIVRREVIRVITPGTVLDGNLLENKKNNYLLSLYKDGTNIGLTYVDISTGETNATCLNEDKVIEEIAKIHPTEIIINDLDFIEKLRDIATVSNIYINESFSDNYLDINILKEYFPDVYLQKLKFDDKGLIKSSLSILLNYIYNTQKQITSNINNINIYNSSEYMVLDMFTRTNLELTQTIRGNKKKGSLLHVLDKTSTAMGGRLLRKYVEEPLINKSKIENRLDVIEEIKDDFILREDLNDILKNIYDIERICGKIAFERVTPKELIHLKNSIEKLPNLKDTINLSNAKILKEYVSEMDKLDDIYNLIDEAILEEPTITIKDGNIIKSDFSDELKELREISKNGAFLVKEIENREREKTGVKSLKIGFNKVFGYYIEITKANFKQAKLDETYIRKQTLSNAERYITPELKEIEEKILHAEEKIKSLEYEIFVEIRDTIYKNIDRIQKVAKTIANIDVFVSLATVAHINNYVKPAINENNKLDIRNGRHPVVENIVGEENFVPNDTYLNRGENIINIITGPNMSGKSTYMRQTAIIALMAHIGSFVPAESADIPILDRIFTRVGASDDLSQGQSTFMVEMNEVSLILKNATERSLVILDEIGRGTSTYDGISLAWSIVEYIQKNIRCKTLFATHYHELTDLEEEFKEVKNYSIAVKEDGEGIIFLRKIIPQGADKSYGIYVAKLAKLPDEVIERAKYILKDLEKNHVYNSVAINGDKENNNIINSNLDEELVKVNQSNFKNKYESLKIEHELIVKDYKHIKKDYDKLNSKFKALNDEVALMKQNDDKEKINQEDSVKEVALTQISFDSVNRDILSEEILNLDILNMTPLDAINSLYNLQRKAKEIKS
|
This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.
|
Q187T6
|
A3CV31
|
DHQS_METMJ
|
3-dehydroquinate synthase II
|
Methanoculleus
|
MKLFWVDLRPWRKDLATTAIESGADALVVEDAERVRKLGRVTAIAENGDLVPGKDVFEIEIVDKESEEEALRLSREGLVIVRTGDWTVIPLENLVAQSDRIVAAVGNADEAKVALTVLERGTAGILLATDDPAEVRRVAKTIAGAGASVPLVPFEVTRIVPVGMGDRVCVDTCSILADGEGMLVGNTSSAFLMVHPETLENPYVAPRPFRVNAGAVHAYILLPGGKTAYLADLAVGDRVLVAEHTGPTHDAVVGRVKIERRPLLLVEAKAGDATVSLVLQNAETIRLVREDGTAVSVAALTVGDRVLGSVAEGGRHFGVAVKETILEK
|
Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis.
|
A3CV31
|
Q91Y94
|
COX42_RAT
|
Cytochrome c oxidase subunit IV isoform 2
|
Rattus
|
MFSRATRSLVMKTGGLRTQGTHSPGSAASSSQRRMTPYVDCYAQRSYPMPDEPYCTELSEEQRALKEKEKGSWAQLSQAEKVALYRLQFHETFAEMNHRSNEWKTVMGCVFFFIGFTALVIWWQRVYVFPKKVVTLTEERKAQQLQRLLDMKSNPIQGLSAHWDYEKKEWKK
|
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
|
Q91Y94
|
C5A282
|
RS19_THEGJ
|
30S ribosomal protein S19
|
Thermococcus
|
MARKKEFRYRGYTLDELLNMSLEEFAKLLPARQRRSLKRGLSPEQKKLLRKIRLAKKGKYNKPIRTHSRDMIVLPEMVGITIHVHNGKEFVPIEIKPEMIGHYLGEFALTRKIVQHGSPGVGATRSSMFVAVK
|
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
|
C5A282
|
A5WHW6
|
RL20_PSYWF
|
50S ribosomal protein L20
|
Psychrobacter
|
MARVKRGVQANRRHKKILKRAKGYYGARSRVYRVAVQAVTKAGQYAYRDRRNKKRTFRRLWIARINAGARLNGLSYSRFINGLKKANIEIDRRVLADIAMHDAAAFTALTEKAKAALA
|
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.
|
A5WHW6
|
A7GZP8
|
PANB_CAMC5
|
Ketopantoate hydroxymethyltransferase
|
Campylobacter
|
MANDKKKLTVNDIKNKKIKGEPIVMMTAYDALFAKIFNDYADIILVGDSLNMSFHLKKETISATMEMMLYHTNAVCAGAKSSFILADMPFGSYSDERSALKNAMKFFKQTEADAVKIEGGMKNVAIIKRLCEEGISVMGHIGLMPQFSKFEGGFKIKGRDETEVKRLMDEAKAIEQAGAFAILLEGTINSVAKQISDSVSVPVIGIGSGADVDGQVLVWSDMLGFFEDFKPKFAKRYLNGAELVRQSVQTYANEVKNRIFPSEEFSYKG
|
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
|
A7GZP8
|
B1JTA2
|
PIMT_BURCC
|
Protein-beta-aspartate methyltransferase
|
Burkholderia cepacia complex
|
MSGERAKRFPLALEDLKRAPRKSEGRPGERQAAGAVPKAADKPAAVLKPVAVKPAAVRAPLPGIAAAKPATAPKPTAPKPALPKPAAPSIAPAGAFALTSERVRERMVERLRANGVTDARVLDAMAAVPRHLFVDPGLATQAYEDSALPIGHQQTISKPSVVARMIELAMAGRTLERVLEIGTGCGYQAAVLSHVARDVYSIERIKPLYERAKLNLRPLRVPNIRLHYGDGRVGLPSAAPFDAIVIAAAGLDVPQALLEQLAIGGRLVAPVGAQSGQHQVLTLVERVAHAQWRESRLDRVFFVPLKSGVI
|
Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
|
B1JTA2
|
A0LW20
|
ISPH_ACIC1
|
4-hydroxy-3-methylbut-2-enyl diphosphate reductase
|
Acidothermus
|
MTEAPPLPKRRVLLAQPRGYCAGVERAVDTVEKALELYGPPVYVRKQIVHNKHVVAELEAKGAIFVEEADEVPEGSIVVLSAHGVAPSVYEQARQRRLKTIDATCPLVTKVHQEARRFAEQGLEILLIGHANHEEVVGTTGEAPSSITLVDGPEEAEHVQVKDPSRVAWLSQTTLSVDETLQTVEVLRRRFPQLIDPPSDDICYATQNRQAAVKRIAAIADLVIVVGSRNSSNSARLVEVALDSGAKASYLVDDASEIDERWLDGVWTVGVTSGASVPESLVTGVLAWLAERGFDTVEEIDAERETLVFALPPELRRELKARGEPLTRSATAGDRMNADR
|
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
|
A0LW20
|
P57094
|
AXIN1_DANRE
|
Axis inhibition protein 1
|
Danio
|
MSMSVNEKGICYLPDLGSSFTEDAPRPPVPGEEGDLVSSDGRQYNHSFYSSKSDSLKNEASIATPRRPDLDLGYEPEGSASPTPPYLKWAESLHSLLDDQDGIHLFRTFLKQEECADMLDFWFACSGFRKQEANDGNEKMLKLAKAIYKKYILDNNGIVSRQIKPATKSFIKDCVTKLHIDPAMFDQAQTEIQTMMEENTYPLFLKSDIYLEYTRTGGESPKLFSDQSSVSGNGKVLPGYLPTVIEDVEWRCDQEEEQIAESDPTPSNRLTQKLPLETVPQRVANSKRYQDNREYRHASWREPVNPYYVNSGYALAPATSANDSEQQSMSSDADTLSLTDSSVDGVPPYRYRKPHRREIHESAKVNGRVPLPHIPRTNRIPKDIHVEPEKFAAELISRLEGVLREREAQEKLEERLKRVRLEEEGDDADISTGPSLANHRVPPAVHVQHYGGRYSEMSYNGLQLRDAHEENPESILDEHVQRVMKTPGCQSPGTGRHSPKSRSPDGLPAGKIPGLMMPLSGGQGKHQARQGPKGEAAHLHHHKHIHHTHYAAAGKPKEQAEAEAARMHGGFAWNTEQHHYGPKSRNYADGMSVGPNTMDPMGYSSKGSTLSKRPVRKGEDGRNFEMREPLPADDMERNQKILQWMMEGEKEAGRYKRGPYGSISGPKKAQGHEPARPSSVERLGAVHPWVTAQLRNNVQPSHPFIQDPTMPPNPAPNPLTQLEEARRRLEEERRKSGTLQAKQRHKNMKKQPCENITVAYYFRGEPIPYRTSVKGRIVTLGQFKELLTKKGSYKYYFKKVSYEFDCGVVFEEVREDDAILPIFEEKIIGKVEKVD
|
Component of the beta-catenin destruction complex required for regulating ctnnb1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling . Controls dorsoventral patterning via two opposing effects: down-regulates ctnnb1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway .
|
P57094
|
Q4UTA4
|
RS18_XANC8
|
30S ribosomal protein S18
|
Xanthomonas
|
MSKFFRRRKFCKFTAEGVKEIDYKDLNTLRQYLTENGKIVPSRVTGTKSKYQRQLATAVKRSRFLALIPYTDNHDV
|
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
|
Q4UTA4
|
Q9K1I8
|
EFG_NEIMB
|
Elongation factor G
|
Neisseria
|
MARKTPISLYRNIGISAHIDAGKTTTTERILFYTGLTHKLGEVHDGAATTDYMEQEQERGITITSAAVTSYWSGMAKQFPEHRFNIIDTPGHVDFTVEVERSMRVLDGAVMVYCAVGGVQPQSETVWRQANKYQVPRLAFVNKMDRQGANFFRVVEQMKTRLRANPVPIVIPVGAEDNFSGVVDLLKMKSIIWNEVDKGTTFTYGDIPAELVETAEEWRQNMIEAAAEASEELMDKYLGGDELTEEEIVGALRQRTLAGEIQPMLCGSAFKNKGVQRMLDAVVELLPAPTDIPPVQGVNPNTEEADSRQASDEEKFSALAFKMLNDKYVGQLTFIRVYSGVVKSGDTVLNSVKGTRERIGRLVQMTAADRTEIEEVRAGDIAAAIGLKDVTTGETLCAESAPIILERMEFPEPVIHIAVEPKTKADQEKMGIALNRLAKEDPSFRVRTDEESGQTIISGMGELHLEIIVDRMKREFGVEANIGAPQVAYRETIRKAVKAEYKHAKQSGGKGQYGHVVIEMEPMEPGGEGYEFIDEIKGGVIPREFIPSVDKGIRDTLPNGIVAGYPVVDVRIRLVFGSYHDVDSSQLAFELAASQAFKEGMRQASPALLEPIMAVEVETPEEYMGDVMGDLNRRRGVVLGMDDDGIGGKKVRAEVPLAEMFGYSTDLRSATQGRATYSMEFKKYSEAPAHIAAAVTEARKG
|
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
|
Q9K1I8
|
A1RVP5
|
SECG_PYRIL
|
Protein transport protein Sec61 subunit beta homolog
|
Pyrobaculum
|
MARRRKYEGLNPFVAAGLIKFSEEGELERIKLNPRTAILVSITVIIAILVLNILHPL
|
Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.
|
A1RVP5
|
Q8A9C2
|
TRMD_BACTN
|
tRNA [GM37] methyltransferase
|
Bacteroides
|
MRIDIITVLPEMIEGFFNCSIMKRAQNKGLAEIHIHNLRDYTEDKYRRVDDYPFGGFAGMVMKIEPIERCINALKAERDYDEVIFTTPDGEQFNQPMANSLSLAQNLIILCGHFKGIDYRIREHLITKEISIGDYVLTGGELAAAVMADAIVRIIPGVISDEQSALSDSFQDNLLAAPVYTRPADYKGWKVPDILLSGHEAKIKEWELQQSLERTKKLRPDLLED
|
Specifically methylates guanosine-37 in various tRNAs.
|
Q8A9C2
|
Q9JZ29
|
RS6_NEIMB
|
30S ribosomal protein S6
|
Neisseria
|
MRHYEIVFIVHPDQSEQVPAMVERYKTMIAEANGKIHRLEDWGRRQLAYPINKIHKAHYVLMNIETTPEVVEELETAFRFNDAILRHLTIKTKHAVTEASPMLGGEKAKNLLSGASEEAVAQ
|
Binds together with S18 to 16S ribosomal RNA.
|
Q9JZ29
|
B0K996
|
YQGF_THEP3
|
Putative pre-16S rRNA nuclease
|
Thermoanaerobacter
|
MRIMGLDVGDKTIGVAISDLSGTIAQGLTTIKRSSNKKDFERIKQIINEYEVGMIIVGLPKNMNGTLGPQGQKVMRFVEHLKEAFSIPIILWDERLTTVEAQRVLIEKADISRAKRKEVIDKLAAVLILQNYLDSQKNK
|
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
|
B0K996
|
Q9HJT1
|
ENO_THEAC
|
2-phosphoglycerate dehydratase
|
Thermoplasma
|
MELPIEEIKVRKVLDSRGNFTVEADVTVPNGFGRTSAPAGASTGETEVIAFSKSGIDASIQFFESKVKRSLIGFNALDQSGFDKLLTDIDGSGNFSNLGGNLATALSMSVAKAAAQSLGIPLYRYVGGIRSTIPRPMGNVIGGGKHARNGTSIQEFLVSAQGSTFLESAYINVLVHRRIGDMLSDKFKDISIGVGDERTWSVNLSDEEAFEILNEAVKEISSEKKVKIYTGVDFAADSLYENGKYVYKHTTKSRDEQIDYAISISKDFGVYYIEDPMYDTDFDGFAEITARIGDRSLIVGDDLYTTNPDRIRKGVEKKSTNAVLIKVNQIGTLSAAREAVAVATFAGMKNIVSHRSGETTDDFLAHLSVAFGSTFVKTGVIGGERVAKLNEIARIEECLTS
|
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
|
Q9HJT1
|
A5V807
|
FOLD2_RHIWR
|
Methenyltetrahydrofolate cyclohydrolase
|
Rhizorhabdus
|
MAPSHAAHDSAATAHRIDGRAIARSLDERTAAAVRAIVARDGAPPGLAVVLVGNDPASEVYVGRKIEACRRVGILSFEHRLPAQTTQDALLTLIARLNADPTIHGILVQVPLPSHIDDGMVLSAIDPAKDVDGFHPVNVGRLSTGTGGLVPCTPLGVMMLLDSVIDDMKGMDAVVIGKSNIVGKPIAMLLLEREATVTVTHIETRGLPDIVRKADIIVAAAGAPRLVKGYWVKEGAVIIDVGITRLPGEGGKTRLVGDVAFDEVQHARAVTPVPGGVGPMTIACLLANTVKAAEMRG
|
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
|
A5V807
|
Q73W20
|
MIAA_MYCPA
|
Isopentenyl-diphosphate:tRNA isopentenyltransferase
|
Mycobacterium avium complex (MAC)
|
MTAAVRPLPIIGPTGTGKSQLALDVAERLGPLGAEIVNADAMQLYRGMDIGTAKLPVDARRGIPHHQLDVLDVTQTATVARYQRAAAADIEAILAAGAVPIIVGGSMLYIQSLLDDWSFPATDPRVRARWERRLGEVGVGELHAELARRDPAAAAAILPTDARRTVRALEVIELTGRPFAASAPRIGAPRWDTVIIGLDCDTTLLDERLARRTDAMFEQGLVAEVTGLLGRGLRDGVTAARALGYAQVIAALDAGGGDEQLRQAREQTYAGTRRYVRRQRSWFRRDHRVRWLDAGACSPPRLADAALEAWRHVS
|
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
|
Q73W20
|
Q5LRZ7
|
AROQ_RUEPO
|
Type II DHQase
|
Ruegeria
|
MTSILVLHGPNLNLLGTRQPEVYGTTTLEMVNSACIAHGQSRGLSVACLQSNHEGALVDAIHAAKGVHRGIVLNAGAYTHTSIALRDAISSVELPVVEVHLSNIHAREAFRHVSHIAPVALGQICGFGAQGYLLALDALAAHLSPEGAR
|
Catalyzes a trans-dehydration via an enolate intermediate.
|
Q5LRZ7
|
Q07RN1
|
HLDE_RHOP5
|
D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase
|
Rhodopseudomonas
|
MLDFEQLSPAIPLQSVLCVGDLMLDEFVYGEVSRISPEAPAPVIAAQRSEIDVGGAGNVARNIASLGARCVFIGLVGDDDAGRTLQTTLAKDALITPVLVCDPSRPTTRKVRFVSEHFSTHMLRADWEVAAPASAAVEQQLIDAVLKQLPAADIVLLSDYAKGVLTARLIRETIDAAKKLGKRVIVDPKSPNFALYRGATLLTPNRKEFCEATRSRADSAAEIATAAREAMDVADCEALLVTQSERGMTLVVREGEAIHVPAHPVKVRDVSGAGDTVAAVLAVMLAAGADWDIALRAANAGAAVAVSKKGTASVSLAELRRKILPHAFLAAEEKIVAAGGDLAPHLAEWRAEGFRIGFTNGCFDILHPGHVKVLTAARAACDRLIVGLNSDASVRRLKGETRPVQDERARAEVLAALEAVDLVAIFDEDTPLRLITEIKPSVLVKGGDYTREQVVGHEVVAANGGEVLLIDILPGHSTTSLVARAQNGKS
|
Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.
|
Q07RN1
|
Q91V26
|
SPHK1_RAT
|
Acetyltransferase SPHK1
|
Rattus
|
MQPADCPRGLLPRPCRVLVLLNPRGGKGKALKLFQSRVRPLLEEAEVSFKLMLTERQNHARELVCAEELGHWDALAVMSGDGLMHEVVNGLMERPDWESAIQKPLCSLPGGSGNALAASLNYYAGHEQVTNEDLLINCTLLLCCRQLSPMNLLSLHTASGRQLYSVLSLSWGFVADVDLESEKYRSLGEIRFTVGTFFRLASLRIYQGQLAYLPVGKAASKIPASSLAQKGPANTYLVPLEEPVPPHWTVVPEQDFVLVLVLLHTHLSTEMFAAPMGRCEAGVMHLFYIRAGVSRAMLVRLFLAMQKGKHMDLDCPYLVHVPVVAFRLEPRNQRGVFSVDGELMVCEAVQGQVHPNYLWMVSGSSDSPSGRDSQRRPPPEEPI
|
Has serine acetyltransferase activity on PTGS2/COX2 in an acetyl-CoA dependent manner. The acetyltransferase activity increases in presence of the kinase substrate, sphingosine. During neuroinflammation, through PTGS2 acetylation, promotes neuronal secretion of specialized preresolving mediators (SPMs), especially 15-R-lipoxin A4, which results in an increase of phagocytic microglia.
|
Q91V26
|
Q92611
|
EDEM1_HUMAN
|
ER degradation-enhancing alpha-mannosidase-like protein 1
|
Homo
|
MQWRALVLGLVLLRLGLHGVLWLVFGLGPSMGFYQRFPLSFGFQRLRSPDGPASPTSGPVGRPGGVSGPSWLQPPGTGAAQSPRKAPRRPGPGMCGPANWGYVLGGRGRGPDEYEKRYSGAFPPQLRAQMRDLARGMFVFGYDNYMAHAFPQDELNPIHCRGRGPDRGDPSNLNINDVLGNYSLTLVDALDTLAIMGNSSEFQKAVKLVINTVSFDKDSTVQVFEATIRVLGSLLSAHRIITDSKQPFGDMTIKDYDNELLYMAHDLAVRLLPAFENTKTGIPYPRVNLKTGVPPDTNNETCTAGAGSLLVEFGILSRLLGDSTFEWVARRAVKALWNLRSNDTGLLGNVVNIQTGHWVGKQSGLGAGLDSFYEYLLKSYILFGEKEDLEMFNAAYQSIQNYLRRGREACNEGEGDPPLYVNVNMFSGQLMNTWIDSLQAFFPGLQVLIGDVEDAICLHAFYYAIWKRYGALPERYNWQLQAPDVLFYPLRPELVESTYLLYQATKNPFYLHVGMDILQSLEKYTKVKCGYATLHHVIDKSTEDRMESFFLSETCKYLYLLFDEDNPVHKSGTRYMFTTEGHIVSVDEHLRELPWKEFFSEEGGQDQGGKSVHRPKPHELKVINSSSNCNRVPDERRYSLPLKSIYMRQIDQMVGLI
|
Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-independent manner, probably by forming a complex with SEL1L. It has low mannosidase activity, catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2.
|
Q92611
|
Q99MS8
|
TPGS1_MOUSE
|
p32
|
Mus
|
MAALPVPLPPTKMAAVEKRRPAVAPAANFPDSGRTSVSQAAAAAESEEDFLRQLGVTEMLRAALLKVLEIRPEEPIAFLAHYFENMGLRSPTNGGAGEPPGQLLLQQQRLGRALWHLRLAHHSQRTAFNNNVSVAYECLSASGRKKKPGLDGRTYSELLKRVCRDGGAPEEVVAPLLRKIQCRDHEAVPLGIFRTGMLSCFVLLEFVARAGALFQLLEDPGQAVADRRVGQAVLDTLEGALSAGDMATAPTHYLEAGSRLGPDNLARALDRAASGRRPSVPMAREEFLEKAAALFIAKVKPVG
|
Subunit of the tubulin polyglutamylase complex (TPGC). The complex mediates cilia and flagella polyglutamylation which is essential for their biogenesis and motility . May act in the targeting of the tubulin polyglutamylase complex. Required for the development of the spermatid flagellum.
|
Q99MS8
|
A7NPB9
|
RSMG_ROSCS
|
16S rRNA 7-methylguanosine methyltransferase
|
Roseiflexus
|
MDELLRIATSWGLRLDQRQIEQFARYSAELRAWNMRVNLTSITDEREIVTRHFLDSLRCALSWGDTPSRLIDIGSGAGFPGLPLKILHPELHVTLVESVGKKAAFLQHIVAVLDLRDVTVVTARAEVVGRDPQHREQYDVVTARAVAELATLVEYGLPLCRIGGRFLAPKGSAIDDEVVRARIAIARLGGQVIGVEPVEIPGVELRTLVVIVKVAPTPAAYPRAVGIPAKRPIL
|
Specifically methylates the N7 position of a guanine in 16S rRNA.
|
A7NPB9
|
Q5NXP3
|
PSD_AROAE
|
Phosphatidylserine decarboxylase beta chain
|
Aromatoleum
|
MSNNYPHPLLAREGWPFIAIALAVALVINGAAGFGWALPFWLLFIFVVQFFRDPPRPIPQGAKDVLSPADGRIVAIEPVRDPYLDRDSVKISVFMNVFNVHSNRSPVDGEVVARWYNAGRFVNAALDKASVENERNALHLRTRDGHDVTCVQVAGLIARRILCYVEAGASLARGQRYGFIRFGSRVDVYLPAGSRARVTIGDKVSASSTILAELP
|
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
|
Q5NXP3
|
Q39266
|
ZFP7_ARATH
|
Zinc finger protein 7
|
Arabidopsis
|
MTESDDASRETPASRGGEASSNQDLSKPESNHVSLDLKLNDTFNDDTKSTKCEANPRVFSCNYCRRKFYSSQALGGHQNAHKRERTMAKRAMHMGRMFGHHHRPYTYTSSSLGMQAHSGLLHHTLSQPQPLVSRFHHQGYFGNTVPLFFDYDDGGSDFFWPGSFRQVVEEAEAPVVVVASTESGLDLNSVAANGGVDNNSSKPDLTLRL
|
Acts as negative regulator of abscisic acid (ABA) signaling during germination and early seedling development.
|
Q39266
|
Q07QW8
|
NUOI1_RHOP5
|
NDH-1 subunit I 1
|
Rhodopseudomonas
|
MKGFGWLEGLLRVGRKLFVKAETVQYPEVRPYLPPRSRGRIVLTRDPDGQERCVACNLCAVACPVGCIDLAKAVAEDGRWYPEHFRINFARCIFCGYCEEACPTAAIQLTPDFELSEWRRDALVYDKHDLLIAGEGKVRGYRYWSVAGKAIQGKDKGEADHEAPPVDLKGLLP
|
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
|
Q07QW8
|
S0DS11
|
APF4_GIBF5
|
Apicidin F synthesis protein 4
|
Fusarium fujikuroi species complex
|
MSIPLPHAEFQWDHYDSKVNPVNGHVECTYRTLTCSWSAPRFVESPFLQVHGLAPGLNYGQQAFEGLLAHRTARNRILIFRPASHSSRFRHSASVVSMPPVPESLFLACVHMAVARNAEFVPPHNFAGNMYIRPLEFGSSAQIGLDVPDEFTFCVFVQPHVPLHGHTPLRALVAEEFDRAATRGTGNCKVGGNYGPVLKWSKDAKKPENGGWSALLHVDSKTQSYVDEFSAAALIGVKSPDQESTQVPILTVAHSEAAIHSITAESVVTIAQSFGWTVERRLVKLEELSSFSEVFAVGTAATIRPCSLIYHRSTGKHFTFTSDGPYYQRLWKTLSGIQKGEIEDIFQWCQDLRFEEFGERGHNGQPTADPTRVIEMPE
|
Aminotransferase; part of the gene cluster that mediates the biosynthesis of the cyclic tetrapeptide apicidin F (APF) . The non-ribosomal peptide synthetase apf1 incorporates four different amino acids to produce apicidin F: L-phenylalanine, D-pipecolic acid (D-pip), N-methoxy-L-tryptophan and L-2-aminooctanedioic acid . L-Phenylalanine is the only proteinogenic amino acid directly used by apf1 . The 3 other apf1 substrates are non-proteinogenic and have to be modified by other enzymes of the cluster . Lysine is converted to delta-1-pyrroline-5-carboxylate (P5C) which is reduced to L-pipecolic acid (L-pip) by apf3 . L-pip is epimerized to D-pip, probably by apf1 activity, prior to incorporation . L-Tryptophan is N-oxidyzed by one of the cytochrome P450 monooxygenases (apf7 or apf8), and further methylated at the hydroxy group by the O-methyltransferase apf6 to yield N-methoxy-L-tryptophan . The synthesis of the fourth apf1 substrate is more complex . The fatty acid synthase apf5 is involved in the synthesis of the octanoic acid backbone of L-2-aminooctanedioic acid by fixing one acetyl-CoA unit and three malonyl-CoA units . Then one of the cytochrome P450 monooxygenases (apf7 or apf8) may oxidize this backbone to 2-oxooctanoic acid . The aminotransferase apf4 is predicted to catalyze the exchange of the keto group with an amino group . The next step would be the oxidation of 2-aminooctanoic acid by one of the cytochrome P450 monooxygenases (apf7 or apf8). The last step is the oxidation of 2-amino-8-hydroxyoctanoic acid to 2-aminooctanedioic acid is catalyzed by the FAD-dependent monooxygenase apf9 .
|
S0DS11
|
A4IWR6
|
RPOA2_FRATW
|
Transcriptase subunit alpha 2
|
Francisella
|
MALENLLHPTNIKIDEYAKNATKFSFEALERGVGYTLGFALKQTMLYSIAGACVTSIKINDGKVTSLEDVIPCDETVADIILNVKSLPVTLAEGVETGTITFELSGSEEEIFSEEAKLSEGLAITEEVFICSYNGGKKLKIEAKVEKGVGFRPAQDNFKDGEFLLDATFSPVVFCDFEIKDARVGRRTDLDKLELNIKTNGNVNCEEALRLAATKIQNQLRNIVDIEEINKGIFVEDPTKDINPILLKHVEELNLTARSSNCLKAVNIRLIGELVQKTENELLKAPNFGKKSLTEIKDKLSELGLSLGTLIENWPQDL
|
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
|
A4IWR6
|
P70698
|
PYRG1_MOUSE
|
UTP--ammonia ligase 1
|
Mus
|
MKYILVTGGVISGIGKGVIASSVGTILKSCGLHVTSIKIDPYINIDAGTFSPYEHGEVFVLDDGGEVDLDLGNYERFLDIRLTKDNNLTTGKIYQYVINKERKGDYLGKTVQVVPHITDAIQEWVMRQALIPVDEDGLEPQVCVIELGGTVGDIESMPFIEAFRQFQFKVKRENFCNIHVSLVPQPSSTGEQKTKPTQNSVRELRGLGLSPDLVVCRCSNPLDTSVKEKISMFCHVEPEQVICVHDVSSIYRVPLLLEEQGVVDYFLRRLDLPIERQSRKMLMKWKEMADRYDRLLETCSIALVGKYTKFSDSYASVIKALEHSALAINHKLEIKYIDSTDLEPSTLQEEPVRYHEAWQKLCSAHGVLVPGGFGVRGTEGKIQAIAWARKQKKPFLGVCLGMQLAVVEFSRNVLGWQDANSTEFDPKTSHPVVIDMPEHNPGQMGGTMRLGKRRTLFQTKNSVMRKLYGDTDYLEERHRHRFEVNPVLKKCLEEQGLKFVGQDVEGERMEIVELEDHPFFVGVQYHPEFLSRPIKPSPPYFGLLLASVGRLPHYLQKGCRLSPRDTYSDRSGSSSPDSEITELKFPSISQD
|
This enzyme is involved in the de novo synthesis of CTP, a precursor of DNA, RNA and phospholipids. Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as a source of nitrogen. This enzyme and its product, CTP, play a crucial role in the proliferation of activated lymphocytes and therefore in immunity.
|
P70698
|
Q2YC50
|
NTPPA_NITMU
|
Nucleotide pyrophosphatase
|
Nitrosospira
|
MTFVENRIYLASRSPRRQELLKQIGVDFMVLPLREALPRIPDVDETPLPQESPPEYVERIARVKAETGRKRMSERGWADFPVLGADTAVVLNGRIFGKPENPLHAKQMLRALSGQIHEVLTAAAVAAGNGTRVCLSRSSVRFRNLGEQEIDHYLACDEAYDKAGAYAIQGRAAVFISGISGSYSGVVGLPLFETAQLLEESAIRIFQ
|
Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
|
Q2YC50
|
Q5FIW0
|
NRDR_LACAC
|
Transcriptional repressor NrdR
|
Lactobacillus
|
MECPNCHQNASRVIDSRPSDENRAIRRRRECENCGFRFTTFERIETAPLLVVKNDGTREPFSRKKILHGVMAAGQKRPISSEQFEHLVDQVENKVRKQGVSEISSKKIGQYVMDDLADLDDVAYIRFASIYREFKDMSSFMKTMEDMMAKKEKGN
|
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
|
Q5FIW0
|
A5CXL5
|
RL24_VESOH
|
50S ribosomal protein L24
|
Candidatus Vesicomyosocius
|
MQKIKSNDEIIIIAGKDKGSIGIVTKIVDSKVLVEGLNLAKKHVKPNPNKGVTGGITEIEMPLSISNVAIYNPTTKKADRVGIRTSKNGIKERFFKSNDKSII
|
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
|
A5CXL5
|
Q72PW7
|
SYG_LEPIC
|
Glycyl-tRNA synthetase
|
Leptospira
|
MEKKESLDSSLKEIVSVCKRRGFVYPGSEIYGGLSNTFDYGPYGVELLQNLKQLWWKYFVHLREDIVGLDSSILLNPKVWEASGHVSNFNDPLIDCKNCKTRIRADKFLEDQKGEGFATGLTLEKMNQVIKESNFACPNCGQRGTFTEARDFNLMFKTSHGASAEDSLDIYLRPETAQGIFLNFKNVVSTTRRKIPFGIAQIGKSFRNEIMARQFVFRTREFEQMEMEFFCEPGTQKEWFSHWVNYCMNWLTEQVGIKKENLRVREHEKEELSFYSEGTSDIEFKYNFGWGELWGIASRTDYDLNQHQKFSGEDLKYQDQVQNKKYVPFVVEPALGVNRLFLAVVTDAYEEEKLPDGETRTVLRFSPKIAPVKAAVFPLMKKDGLPEKSREIFADLSKLGNIEYDDGGAIGKRYRRQDEIGTPFCITVDYDTLKDNTVTVRERDSMSQERIAVNQLKNWLFERL
|
Catalyzes the attachment of glycine to tRNA(Gly).
|
Q72PW7
|
B5Z7J3
|
ATP6_HELPG
|
F-ATPase subunit 6
|
Helicobacter
|
MEHRVFTIANFFSSNHDFITGFFVVLTAVLMFLISLGASRKMQMVPMGLQNVYESIISAILSVAKDIIGEELARKYFPLAGTIALYVFFSNMIGIIPGFESPTASWSFTLVLALIVFFYYHFEGIRVQGFFKYFAHFAGPVKWLAPFMFPIEIISHFSRIVSLSFRLFGNIKGDDMFLLIMLLLVPWAVPVAPFMVLFFMGILQAFVFMILTYVYLAGAVLTDEGH
|
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
|
B5Z7J3
|
Q3T084
|
TCPW_BOVIN
|
CCT-zeta-2
|
Bos
|
MAAIKAINSKAEVARAQAALAVNICAARGLQDVLRTNLGPKGTMKMLVSGAGDVKLTKDGNVLLHEMQIQHPTASLIAKVATAQDDITGDGTTSNVLIIGELLKQADLYISEGLHPRIIAEGFEIAKIKALEVLEQVKIKKEMKREIHLDVARTSLQTKVHPQLADVLTEAVVDSVLAIRRPNYPIDLFMVEIMEMKHKSETDTKLIKGLVLDHGARHPDMKKRVDDAFILTCNVSLEYEKTEVSSGFFYKTAEEKEKLVKAERKFIEDRVQKIIDLKDKVCAQSNKGFVVINQKGIDPFSLDALAKHGILALRRAKRRNMERLSLACGGVAVNSVEDLSVDCLGHAGLVYEYTLGEEKYTFIEDCINPRSVTLLVKGPNKHTLTQIKDAVRDGLRAIKNAIEDGCVVPGAGAVEVVIAEALVTYKHTIQGRARLGVQAFADALLIIPKVLAQNSGYDLQETLVKVQAEHSNSKQPVGIDLNTGEPMVAADAGVWDNYCVKKQLLHSCTVIATNILLVDEIMRAGMSSLKG
|
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis.
|
Q3T084
|
Q5R8Q4
|
PATL1_PONAB
|
Protein PAT1 homolog b
|
Pongo
|
MFRYESLEDCPLDEDEDAFQGLGEEDEEIDQFNDDTFGSGAVDDDWQEAHERLAELEEKLPVAVNEQTGNGERDEMDLLGDHEENLAERLSKMVIENELEDPAIMRAVQTRPVLQPQPGSLNSSIWDGSEALRRIRGPLLAQEMPTVSVLEYALPQRPPQGPEDDRDLSERALPRRSTSPIIGSPPVRAVPIGTPPKQMAVPSFTQQILCPKPVHVRPPMPPRYPAPYGERMSPNQLCSVPNSSLLGHPFPPSVPPVLSPLQRAQLLGGAQLQPGRMSPSQFARVPGFVGSPLAAMNPKLLQGRVGQMLPPAPGFRAFFSAPPSATPPPQQHPPGPGPHLQNLRSQAPMFRPDTTHLHPQHRRLLHQRQQQNRNQHRNLNGAGDRGSHRSSHQDHLRKDPYANLMLQREKDWVSKIQMMQLQSTDPYLDDFYYQNYFEKLEKLSAAEEIQGDGPKKERTKLITPQVAKLEHTYKPVQFEGSLGKLTVSSVNNPRKMIDAVVTSRSEDDETKEKQVRDKRRKTLVIIEKTYSLLLDVEDYERRYLLSLEEERPALMDERKHKICSMYDNLRGKLPGQERPSDDHFVQIMCIRKGKRMVARILPFLSTEQAADILMTTARNLPFLIKKDAQDEVLPCLLSPFSLLLYHLPSVTITSLLQQLMNLPQSAATPAPSNPHLTAVLQNKFGLSLLLILLSRGEDLQSSDPATESTQNNQWTEVMFMATRELLRIPQAALAKPISIPTNLVSLFSRYVDRQKLNLLETKLQLVQGIR
|
RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs. Acts as a scaffold protein that connects deadenylation and decapping machinery. Required for cytoplasmic mRNA processing body (P-body) assembly.
|
Q5R8Q4
|
B9E7C9
|
RS4_MACCJ
|
30S ribosomal protein S4
|
Macrococcus
|
MARFTGSTWKKSRRLGISLSGTGKELERRPYAPGQHGPNQRKKLSEYGLQLQEKQKLRYMYGINERQFRTIFDRAGKMKGIHGANFMALLASRLDAVVYQLGLARTRRQARQLVNHGHIMVDGARVDIPSYQLKPGQVISVREKSQKLNIIAESVELSNHVPEYLTFDADKLEGTFVRVPERSELSAEINEQLIVEYYSR
|
With S5 and S12 plays an important role in translational accuracy.
|
B9E7C9
|
Q20EY4
|
YCF12_OLTVI
|
Photosystem II reaction center protein Ycf12
|
Oltmannsiellopsis
|
MSLEVILQLGSILLVVAAGPLVIVLLSVNEGNL
|
A core subunit of photosystem II (PSII).
|
Q20EY4
|
Q2RUI7
|
CHED_RHORT
|
Probable chemoreceptor glutamine deamidase CheD
|
Rhodospirillum
|
MVNSMPKPFLTPGTLYCGAAPAVISTVLGSCVAVCLIDRHNRAAGMNHFVLPHNPAGEDSLRYGDVALDRLHARMGELGCETKDLRAKVFGGAAVLPFGATGDSVGTKNVKIAIEWLHAQGIPTLARRTGGENGLLIRFYTATGRVLVRTIQSAITIDLGGISPAFDSRQSPFFQE
|
Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.
|
Q2RUI7
|
Q03UM3
|
LEUD_LEUMM
|
Isopropylmalate isomerase
|
Leuconostoc
|
MEAFVRETGRAVVIPNDNINTDIILPKQFLKNILKTGFGKDLFFDWRYNADGSLNEAFELNKPAHQGASILITGNDFGSGSSREHAVWALTDYGFRAVIGGGFSDIFYMNSTKNGLLPIVLPEENRKILRGIQADENIQIDLPEQTVTYKNYTFHFDINSQWKEKFINGEDDIDNTMKYEKLIAAFEKQRPNFG
|
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
|
Q03UM3
|
Q819X7
|
HSLU_BACCR
|
Unfoldase HslU
|
Bacillus cereus group
|
MHLHFTPRQIVEKLDQYIIGQKDAKKAVAVALRNRYRRSKLAENLRDEIAPKNILMIGPTGVGKTEVARRMAKLVGAPFIKVEATKFTEVGYVGRDVESMVRDLVETSVRIVKEEMVVKVQDKAEEQANQRLVEILVPSPEKQSGFKNPLEMLFGGAQNSNQTSDTQEDVEIEKKRQDVERKLAAGLLEEEIVSIEVTEQQSSMFDMLQGTGMEQMGMNFQDALGSFMPKKTKKRKLSVKEARKLLSNEEAQRLIDMDEVTQEAVYRAEQLGIIFIDEIDKIAGKQSNSVDVSREGVQRDILPIVEGSNVATKYGSVKTDYILFVAAGAFHMSKPSDLIPELQGRFPIRVELTKLSTDDFVKILIEPDNALIKQYMALLATEGIEIEFSDEAIRKIAEIAYQVNQDTDNIGARRLHTIMEKLLEDLSFEASEITLEKITITPQYVEEKLATIAKNKDVSQFIL
|
ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
|
Q819X7
|
Q4AAW0
|
ATPD_MESHJ
|
F-type ATPase subunit delta
|
Mesomycoplasma
|
MYLYKKNYYGYAESLLDISISENNVEKYINDCFFILSIIQNNQVLILLFKSHFIGKQEKFNIIDKIFSAKIEKILVNFLKVIAKNNLFLYYKQILLKYIKLANSHLSQTWGEIETAFPISSVMTSSFESILSKKLGKKVHLRHKINSKLISGIRIIVDNQIFENSLFSELKLLKQNLKKHLITKNDL
|
This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
|
Q4AAW0
|
A8GVV6
|
RSMH_RICB8
|
rRNA (cytosine-N(4)-)-methyltransferase RsmH
|
belli group
|
MQQPHIPVMLNEMLKFLAPKAGESYLDCTFGAGGYSKALLENCDCYVTALDRDPNVIKKAEEIKHNYKDRFDFVETNFGNCFAKLESKKFDGIVLDLGVSSMQLDIPDRGFSFLHDGPLDMRMSGQGLSAEEFINTAEEKDLADVIYKYGDETFSRRIAKKIVEVRKAARIDSTGKLADIVHSCIGFRKGKIDPATKTFQAIRIYINNELGELEQFLANVKNILKKDGRLVVVSFHSLEDRIVKNFFKENSEKPVARSKYAKEDIMLNPDKWLKIITNKAEIPSDKEISLNVRARSAKLRAAKKI
|
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
|
A8GVV6
|
Q9VSR3
|
ORB2_DROME
|
Translational regulator orb2
|
Sophophora
|
MDSLKLPKANSATSSASGSNSNLSGSTSASASAATSPTSSGTAVGGILSGAPKSPPGLGSSTPISVRFNANEESLDDILQSFHHSKHSPSGGASGGGDASPTSNLLGMKNNGLGLVVGNCDSLSSSPSQPQMHAGSASLFGNDEVSLRNNFMQAGGFFNRKSCGGLPNLNLNKPPQLHQQQHQQQHQQHQQHQQQQQLHQHQQQLSPNLSALHHHHQQQQQLRESGGSHSPSSPGGGGGGSPYNGSQAGCSSGGISPIPPQMGVSPKYRRSISFPIKGNSPTAIYGNMHMDGMGSGHMNIPTLSIGNGGGGGSTGMVSAGATGGGDAPYLGNSYGNMMTSNGQMHHGGGLDNSLCDYMRNMSLGGNGGGDGSNSMSLMQDRMRVMGGPKHLSEADAMAIAASGNDPSVYLNALKMGSPSRLSPHSPHSPIQGGNGGNVGDGTARFSRKVFVGGLPPDIDEDEITTSFRRFGPLVVDWPHKAESKSYFPPKGYAFLLFQDESSVQQLIDSCITDEDKLYLCVSSPTIKDKAVQIRPWRLADADYVLDATMSLDPRKTVFVGGVPRPLKAFELAMIMDRLYGGVCYAGIDTDPELKYPKGAGRVAFSNQQSYIAAISARFVQLQHGDIDKRVEVKPYVLDDQMCDECEGQRCGGKFAPFFCANVTCLQYYCEHCWAVIHSRPGREYHKPLVKEGADRPRAVPFRWC
|
Required for initial memory acquisition . Following subsequent late dopaminergic pathway activation, recruits isoform B into a complex to activate translation of CaMKII which is required for long-term memory consolidation .
|
Q9VSR3
|
A8M518
|
RL24_SALAI
|
50S ribosomal protein L24
|
Salinispora
|
MTVKVKKGDTVVVIAGKDKGAKGKVIAAYPRQDKVLVEGVNRVKKHTRISTTQRGAKTGGIVTQEAPIHVSNVMVVDSDGKPTRVGYRIDENGQKVRIARSTGKDL
|
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
|
A8M518
|
Q39YM0
|
FTSW_GEOMG
|
Peptidoglycan polymerase
|
Geobacter
|
MNLNFKLNLKEIERYDLVILLMAVALTCFGVVMVYSASSVMATKKFHDGFYFLKRQGIYAILGCAAMIVAMRIDYRQWREYAVPILLGCLLLLLLVFIPGIGGAAKGASRWIRFPGFNLQPSELAKIALIMYMAYSLDKKQEKVKFFSTGFAPYMVLLAILLAILLKQHDLGSALTMGGVAILMLFAAGTRPRYILGMVVLTLPFLYFLVMNVDYRRRRILAYLNPWEDPTNTGFQIIQSWLAFGNGGIIGQGLGEGKQKMFFLPEAHTDFILSVVGEELGLIGVIVIAAMFLMLVLRGVRVALMAQDPFGRFLAFGIVTLLGIQAFVNMGVVTGLLPTKGLALPFISYGGSSLIVTLFAVGILLNVSTRMKGTP
|
Peptidoglycan polymerase that is essential for cell division.
|
Q39YM0
|
P04391
|
OTC1_ECOLI
|
Ornithine carbamoyltransferase subunit I
|
Escherichia
|
MSGFYHKHFLKLLDFTPAELNSLLQLAAKLKADKKSGKEEAKLTGKNIALIFEKDSTRTRCSFEVAAYDQGARVTYLGPSGSQIGHKESIKDTARVLGRMYDGIQYRGYGQEIVETLAEYASVPVWNGLTNEFHPTQLLADLLTMQEHLPGKAFNEMTLVYAGDARNNMGNSMLEAAALTGLDLRLVAPQACWPEAALVTECRALAQQNGGNITLTEDVAKGVEGADFIYTDVWVSMGEAKEKWAERIALLREYQVNSKMMQLTGNPEVKFLHCLPAFHDDQTTLGKKMAEEFGLHGGMEVTDEVFESAASIVFDQAENRMHTIKAVMVATLSK
|
Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline, which is a substrate for argininosuccinate synthetase, the enzyme involved in the final step in arginine biosynthesis.
|
P04391
|
A6TDT2
|
E4PD_KLEP7
|
D-erythrose-4-phosphate dehydrogenase
|
Klebsiella
|
MTIRIAINGFGRIGRNVVRALYESGRRAEITVVAINELADAAGIAHLLKYDTSHGRFAWDVRQEREQLFVGDDSIRLLHEPTIAALPWRELAVDVVLDCTGVYGSREHGEAHLQAGAKKVLFSHPGGNDLDATVVYGVNQDELRAGHRIVSNASCTTNCIIPIIKLLDDAYGIESGTVTTIHSAMHDQQVIDAYHPDLRRTRAASQSIIPVDTKLAAGITRIFPQFNDRFEAIAVRVPTINVTAIDLSVTVKKPVKACEVNQLLQKAAQGAFHGIVDYTELPLVSTDFNHDPHSAIVDGTQTRVSGAHLIKTLVWCDNEWGFANRMLDTTLAMAAIGFRFDA
|
Catalyzes the NAD-dependent conversion of D-erythrose 4-phosphate to 4-phosphoerythronate.
|
A6TDT2
|
P15388
|
KCNC1_MOUSE
|
Voltage-gated potassium channel subunit Kv4
|
Mus
|
MGQGDESERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDYDPRADEFFFDRHPGVFAHILNYYRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSFGGAPLDNSADDADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIWALFEDPYSSRYARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYYREAETEAFLTYIEGVCVVWFTFEFLMRVVFCPNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKKKHIPRPPQLGSPNYCKSVVNSPHHSTQSDTCPLAQEEILEINRAGRKPLRGMSI
|
Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient . Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNC2, and possibly other family members as well. Contributes to fire sustained trains of very brief action potentials at high frequency in pallidal neurons.
|
P15388
|
Q5HHY5
|
UPPP_STAAC
|
Undecaprenyl pyrophosphate phosphatase
|
Staphylococcus
|
MFIIELIKGIILGVVEGLTEFAPVSSTGHMILVDDMWLKSSEFLGSQSAFTFKIVIQLGSVFAAAWVFRERFLEILHIGKHKHVEGDNDQQRRSKPRRLNLLHVLVGMVPAGILGLLFDDFIEEHLFSVPTVMIGLFVGAIYMIIADKYSAKVKNPQTVDQISYFQAFVIGISQAVAMWPGFSRSGSTISTGVLMKLNHKAASDFTFIMAVPIMLAASGLSLLKHYQDIQIADIPFYILGFLAAFTVGLIAIKTFLHQINKIKLIPFAIYRIVLVIFIAILYFGFGIGKGI
|
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
|
Q5HHY5
|
B3VTV7
|
MYB60_VITVI
|
Myb domain protein 60
|
Vitis
|
MGRPPCCDKVGIKKGPWTPEEDIILVSYIQEHGPGNWRSVPTNTGLLRCSKSCRLRWTNYLRPGIKRGNFTPHEEGMIIHLQALLGNKWAAIASYLPQRTDNDIKNYWNTHLKKKIKKFQSALSPHMASDSTTSTCTNHQFVPRSYAGDDHHRRGSSFEVINGHSSAHPSLNSPISTYASSTENISRLLEGWMRSSPKATKEKLHQNSSLEEGSIDMTGNSMAVAAVTSVQCYRPKLEQGGGELVANDEFESILEYENLNDDHHQTTDATIPSDDHDHDHEMKMDHDQKKHNPPLSFLEKWLLDESAAQGEEMMDQLSPIF
|
Transcription factor involved in the regulation of gene (e.g. drought-regulated and flavonoid biosynthetic genes) expression and stomatal movements leading to negative regulation of responses to drought and responses to other physiological stimuli (e.g. light).
|
B3VTV7
|
Q6IRC5
|
TXND6_XENLA
|
Thioredoxin-like protein 2
|
Xenopus
|
MAGKKRESSLQIALSNQEQWEEALSTKGLQVVDVYQAWCGPCKPTVSLFRKIKNELGDDLLHFAVAESDTIDSLVKYRGKCEPTFLFLAGGELVAVVRGANGPLLQKTIIEQLAAEKKVLNQGSERHVIKDEVLLEEEDEIAPVQAQTEDEELVPSGKSYTVAIIKPDAVAHGKTDEIIMKIQESGFEILANEERTMTESEAREFYQHRAGEEKFQELIQFMSSGPCHILIISKSEEDEDVIPAWREFIGPTDVEIAKKEKPESLRAQYGTEVLYNAVHGSNDREQASRELAFFFPNFKISNESLKELTSVKPERTLALIRPEILKERKDEILQSIKDAGFSIAMQKEVMLTEHQVQEFYKEHINEDYYPALLKQMTSGPVLALALVKDNAVGHWRNMLGPASLSQALSEAPDSLRAQFAPSDSETNQLHGSSTTEEAKKEINFFFPVEHTLATIKPDALEEHRDEILEQIQGAGFTISQIKEANLNREMAEEFYKEHKGKPFFEQLVNYMCRGPCLMMILSKENAVHEWRSLMGPTDPAEAQKVLPDSLRGKFAKSILQNAVHGSSNSDHAMEKIKFIFGDIDLDRIVHESFGETPETSASDISRNAAAQGDDPEQDESKEMEE
|
May be a regulator of microtubule physiology.
|
Q6IRC5
|
Q3AMC3
|
CYB6_SYNSC
|
Cytochrome b6
|
unclassified Synechococcus
|
MANSSPVYDWFQERLEIQDIADDIGSKYVPPHVNIFYCLGGITLVCFLIQFATGFAMTFYYKPTVAEAYKSVEYLMTDVSFGWLIRSVHRWSASMMVLMLILHVFRVYLTGGFKRPRELTWVTGVTMAVITVSFGVTGYSLPWDQVGYWAVKIVSGVPAAIPVVGDFMVELLRGGESVGQATLTRFYSLHTFVMPWLLAVFMLMHFLMIRKQGISGPL
|
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
|
Q3AMC3
|
Q2P5V2
|
MURD2_XANOM
|
UDP-N-acetylmuramoyl-L-alanyl-L-glutamate synthetase
|
Xanthomonas
|
MRISQFEGKAVALWGWGREGRGAYRALRAQLPTQSLTMFCNAEEVRELESLADAALHVETDASAQALGRFEIVVKSPGISPYRAEALAAAAQGTQFIGGTALWFAEHAQPDGSVPGAICVTGTKGKSTTTALLAHLLRVAGHRTALVGNIGQPLLEVLAPQPPPAYWAIELSSYQTGDVGRSGARPELAVVLNLFPEHLDWHGDEARYVRDKLSLVTEGRPRIVLLNAADPLLASLQLPDSEVLWFNHPEGWHLRGDVVYRGEQAIFDSADVPLPGVHNRRNLCAVLAALEALGLDAEALAPAALSFRPLPNRLQVLGSVDGISYVNDSISTTPYASLAALACFAQRRVALLVGGHDRGLDWHDFARHMAQQAPLEIVTMAANGPRIHALLAPLADAGRFGLHAANDLEHAMQLARDALGGQGGVVLLSPGAPSFGAYSDYVARGRHFAQLAGFDPAAISAIPGLGVH
|
Cell wall formation. Catalyzes the addition of L-glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine. Has weak activity with D-glutamate.
|
Q2P5V2
|
A1S3Y1
|
RNC_SHEAM
|
Ribonuclease III
|
Shewanella
|
MEPIKNLPRLCRTLGYEFSDIRLLEQALTHRSASNQHNERLEFLGDSILSIVISDALFHQFPKATEGDLSRMRATLVRGDTLAVIAKEFKLGDYLNLGPGELKSGGFRRESILADAVEAIIGAVYLDADLETCRSLLLGWYETRLADIKPGVGQKDAKTLLQEYLQGMKKPLPEYQVTQVEGEAHDQTFTVECRVTDLADAVVGVGSSRRKAEQMAAAQVLELLNQ
|
Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
|
A1S3Y1
|
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