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<|newrecord|> nctId: NCT06340347 id: C5351010 briefTitle: A Study to Learn How the Body Processes the Study Medicine Called Osivelotor (PF-07940367) in People With Loss of Liver Function overallStatus: NOT_YET_RECRUITING date: 2024-04-24 date: 2026-02-05 date: 2026-02-05 date: 2024-04-01 date: 2024-04-01 name: Pfizer class: INDUSTRY briefSummary: The purpose of this study is to understand how Osivelotor is processed in people with loss of liver function.
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This study is seeking participants that are:
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* stable loss of liver function with mild or moderate severity
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* none of underlying conditions possibly affecting the study medicine being absorbed by the body
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All participants will receive one amount of Osivelotor by mouth before breakfast on the first day at the study clinic. A number of blood samples will be collected to understand how Osivelotor is changed and removed from the body. Participants will also have to undergo physical examination and other tests. This will help to understand if Osivelotor is safe.
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Participants will take part in the study for a maximum of 112 days. During this time, participants will have to stay onsite for 5 days. There will be 5 study visits at the study clinic. conditions: Liver Diseases studyType: INTERVENTIONAL phases: PHASE1 allocation: NON_RANDOMIZED interventionModel: PARALLEL interventionModelDescription: An open label, single dose, parallel cohort study primaryPurpose: BASIC_SCIENCE masking: NONE count: 16 type: ESTIMATED name: Osivelotor measure: Area under the whole blood and plasma concentration versus time curve (AUC) from time zero (pre-dose) to the last quantifiable concentration (AUClast) of osivelotor measure: Area under the whole blood and plasma concentration versus time curve (AUC) from time zero (pre-dose) to extrapolated infinite time (AUCinf) of osivelotor measure: Maximum observed whole blood and plasma concentration (Cmax) of osivelotor measure: Number of Participants With Treatment-Emergent Adverse Events (AEs) measure: Number of Participants With Clinically Significant Laboratory Abnormalities measure: Number of Participants With Clinically Significant Electrocardiogram (ECG) Findings measure: Number of Participants With Clinically Significant With Clinically Significant Vital Signs sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
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<|newrecord|> nctId: NCT06340334 id: KY20240123-05 briefTitle: Efficacy and Safety of Tegoprazan Dual Therapy and Furazolidone-based Bismuth Quadruple Therapy for Helicobacter Pylori Eradication: A Prospective, Multicenter, Open-label, Randomized Controlled Clinical Study overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2024-12-31 date: 2024-12-31 date: 2024-04-01 date: 2024-04-01 name: Nanjing First Hospital, Nanjing Medical University class: OTHER briefSummary: To compare the efficacy and safety of Tegoprazan-amoxicillin dual therapy and bismuth quadruple therapy based on furazolidone in the treatment of Helicobacter pylori eradication, the eradication rate, patient compliance, and adverse drug reactions of H. pylori infection were compared in a multi-center clinical joint study in Jiangsu Province. conditions: Helicobacter Pylori Infection conditions: Tegoprazan conditions: Furazolidone studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 600 type: ESTIMATED name: Tegoprazan-amoxicillin dual therapy measure: Helicobacter pylori eradication rate measure: Security observations measure: Patient compliance sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
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<|newrecord|> nctId: NCT06340321 id: PBRC 2023-081 briefTitle: Impact of Metabolic Flexibility on Changes in Metabolic Health acronym: METPROS overallStatus: ENROLLING_BY_INVITATION date: 2024-06 date: 2025-01 date: 2025-01 date: 2024-04-01 date: 2024-04-03 name: Pennington Biomedical Research Center class: OTHER briefSummary: Metabolic flexibility is the capacity to adapt fuel oxidation to fuel availability so that ATP synthesis can match its cellular demands. Thus, for example, increases in glucose availability after a meal would increase glucose oxidation, while increases in lipid availability during fasting would increase lipid oxidation. Enhanced metabolic flexibility has been proposed to protect humans from metabolic diseases. Nevertheless, most studies examining associations between metabolic flexibility and metabolic health outcomes have used cross-sectional designs. Whether impaired metabolic flexibility causes or results from metabolic health impairment is thus unclear.
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In this study, the investigators will use the data from a study conducted approximately 16 years ago in healthy participants without obesity. Using the data already collected in that study, the metabolic flexibility of each participant will be calculated. To test the association between metabolic flexibility and the change in metabolic health, the investigators will call back all the participants for a single follow-up visit to reassess several metabolic health outcomes. Thus, the main aim of the study is to test the association between metabolic flexibility and the change in metabolic health outcomes after 16 years in humans. conditions: Obesity conditions: Metabolic Syndrome studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 88 type: ESTIMATED name: Metabolic flexibility in the fasted state name: Metabolic flexibility in euglycemic-hyperinsulinemic clamp name: Metabolic flexibility in the metabolic chamber measure: Glucose measure: Total cholesterol measure: HDL cholesterol measure: LDL cholesterol measure: Triglycerides measure: HOMA-IR measure: Blood pressure measure: Waist circumference measure: Body mass index measure: Body fat percentage sex: ALL minimumAge: 20 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Pennington Biomedical Research Center city: Baton Rouge state: Louisiana zip: 70808 country: United States lat: 30.45075 lon: -91.15455 hasResults: False
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<|newrecord|> nctId: NCT06340308 id: PARAF 986117570 briefTitle: Clinical Study With Berberine-based Food Supplement, Artichoke Extract, Phytosterols, Fenugreek and SelectSIEVE® OptiChol acronym: PARAF overallStatus: RECRUITING date: 2023-06-07 date: 2024-03 date: 2024-05 date: 2024-04-01 date: 2024-04-01 name: University of Pavia class: OTHER name: Foundation IRCCS San Matteo Hospital briefSummary: To evaluate the effects of a nutraceutical containing Berberine-based Food Supplement, Artichoke Extract, Phytosterols, Fenugreek and SelectSIEVE® OptiChol on lipid profile conditions: Dyslipidemias studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: PARTICIPANT count: 36 type: ESTIMATED name: Berberine-based Food Supplement, Artichoke Extract, Phytosterols, Fenugreek and SelectSIEVE® OptiChol name: Berberine-based Food Supplement, Artichoke Extract, Phytosterols, Fenugreek and SelectSIEVE® OptiChol measure: Variations of lipid profile sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: IRCCS Policlinico S. Matteo Foundation status: RECRUITING city: Pavia zip: 27100 country: Italy name: Giuseppe Derosa, MD, PhD role: CONTACT email: [email protected] name: Pamela Maffioli, MD role: CONTACT email: [email protected] name: Giuseppe Derosa, MD, PhD role: PRINCIPAL_INVESTIGATOR name: Pamela Maffioli, MD role: SUB_INVESTIGATOR lat: 45.19205 lon: 9.15917 hasResults: False
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<|newrecord|> nctId: NCT06340295 id: 2023313 briefTitle: A Multicenter, Prospective Cohort Study of Preserved Ratio Impaired Spirometry(PRISm) in a Population overallStatus: RECRUITING date: 2023-09-01 date: 2026-05-31 date: 2026-05-31 date: 2024-04-01 date: 2024-04-01 name: Peking University First Hospital class: OTHER name: Shanxi Bethune Hospital name: First Affiliated Hospital Xi'an Jiaotong University name: Tianjin Medical University General Hospital name: The First Hospital of Qinhuangdao name: Shandong Provincial Hospital name: Second Hospital of Jilin University name: People's Hospital of Xinjiang Uygur Autonomous Region name: MinDong Hospital of Ningde City briefSummary: Chronic obstructive pulmonary disease (COPD) is the most common chronic tract disease and the third leading cause of death worldwide. The treatment effect of COPD is poor, and the disease is progressive, resulting in a serious disease burden. The key reason is that early recognition is difficult and the early pathophysiological mechanism is unclear, which leads to the difficulty of early intervention.PRISm is likely to be the precursor stage of COPD, which may provide an important research object for the study of pathophysiological characteristics, inflammation and immunomodulatory mechanisms of early COPD, and may also become a new entry point for early intervention of COPD. This study attempts to establish a PRISm prospective cohort，and collects blood, EBC and urine for analysis of inflammatory factors, metabolomics, proteomics and microbiome, and performs chest HRCT to obtain imaging indicators, and conducts 3-year dynamic follow-up observation to study the evolution characteristics of pulmonary function and the incidence of COPD in the PRISm cohort. To compare the differences in imaging, inflammatory factors, metabolomics, proteomics and microbiome among the three PRISm groups, and establish a risk prediction model for progression to COPD through PRISm. It lays a foundation for understanding the characteristics of COPD at an earlier stage and exploring new early warning indicators. conditions: COPD studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 2000 type: ESTIMATED measure: The number and proportion of newly diagnosed COPD measure: The number and proportion of continuous PRISm population measure: The number and proportion of PRISm to normal population measure: Emerging diseases measure: Death and cause of death sex: ALL minimumAge: 20 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Peking University First Hospital status: RECRUITING city: Beijing state: Beijing zip: 100034 country: China name: Jiping Liao, MD. role: CONTACT phone: 13521714181 email: [email protected] name: Chunbo Zhang role: CONTACT phone: 13086645758 email: [email protected] name: Jiping Liao, MD. role: PRINCIPAL_INVESTIGATOR name: Guangfa Wang, MD. role: SUB_INVESTIGATOR name: Zhe Jin, MD. role: SUB_INVESTIGATOR name: Meng Zhang role: SUB_INVESTIGATOR name: Yan Hu, MD. role: SUB_INVESTIGATOR name: Chunbo Zhang role: SUB_INVESTIGATOR name: Xueying Li role: SUB_INVESTIGATOR name: Jian Chen role: SUB_INVESTIGATOR lat: 39.9075 lon: 116.39723 facility: Peking University First Hospital status: RECRUITING city: Beijing state: Beijing zip: 100034 country: China name: Guangfa Wang, MD role: CONTACT phone: 13810644029 email: [email protected] name: Jiping Liao, MD role: CONTACT phone: 13521714181 email: [email protected] name: Yunxia Wang, PhD role: SUB_INVESTIGATOR name: Yijue Zhong, PhD role: SUB_INVESTIGATOR name: Chao Sun, PhD role: SUB_INVESTIGATOR lat: 39.9075 lon: 116.39723 facility: The First Hospital of Qinhuangdao status: RECRUITING city: Qinhuangdao state: Hebei country: China name: Hua Qiao, MD role: CONTACT phone: 13780358298 email: [email protected] lat: 39.93167 lon: 119.58833 facility: Tianjin Medical University General Hospital status: RECRUITING city: Tianjin state: Tianjin country: China name: Lixia Dong, MD role: CONTACT phone: 13001385918 email: [email protected] lat: 39.14222 lon: 117.17667 facility: Shandong Provincial Hospital Affiliated to Shandong University status: RECRUITING city: Jing'an country: China name: Jian Sun, MD role: CONTACT email: [email protected] facility: Shanxi Bethune Hospital status: RECRUITING city: Taiyuan country: China name: Ruiying Wang, MD role: CONTACT phone: +86 13903436432 email: [email protected] lat: 37.86944 lon: 112.56028 hasResults: False
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<|newrecord|> nctId: NCT06340282 id: MOTOMED briefTitle: Immersive Virtual Reality and Physical Exercise on Cognitive and Functional Performance in Hospitalized Older Patients acronym: MOTOMED overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2025-04-01 date: 2025-04-01 date: 2024-04-01 date: 2024-04-03 name: Fundacion Miguel Servet class: OTHER briefSummary: This study will be conducted in a hospital in Spain to investigate how a special intervention using immersive virtual reality technology can benefit hospitalized older adults with difficulties in their daily functionality.
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The main objective of this study is to evaluate whether a cognitive stimulation intervention through immersive virtual reality, along with specific physical exercises, can improve the cognitive and physical function of hospitalized older patients. It is expected that this innovative intervention will have a positive impact on the quality of life of these patients.
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Participants eligible for the study must be over 75 years old, have severe functional dependency upon hospital admission, and be willing to participate. Those with severe dementia or other terminal illnesses will be excluded.
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Participants will be randomly assigned to one of four study groups: a control group without intervention and three intervention groups, including viewing Spanish landscapes through virtual reality, performing specific physical exercises, or a combination of both interventions.
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At the end of the study, various aspects such as cognitive and physical function, mood, quality of life, muscle strength, and acceptance of virtual reality technology by patients will be evaluated.
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This study aims to provide new insights into the care of hospitalized older adults and explore innovative ways to improve their well-being during their hospital stay conditions: Disability Physical conditions: Cognition studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: This clinical randomized controlled trial will be conducted in the Acute Geriatric Unit of a tertiary hospital in Spain. A total of 212 acute patients will be enrolled according to the following criteria: age \> 75, Barthel Index \< 60, able to collaborate, expected length of stay \> 5 days, absence of clinical instability and severe dementia (GDS 7) or other end-stage disease. Patients will be randomly assigned to a control group (CG) or any of the three intervention groups (IG): IVR, ME, or IVR + ME. The IVR group will watch ad-hoc videos showing Spanish regional landscapes and villages, approximately 4 minutes per day for three consecutive days. The ME group will undergo aerobic and strength exercise for progressive training of the upper and lower limbs. The IVR + ME group will do both cognitive and physical intervention. The primary outcomes will be cognitive and physical measures at discharge. Mood, quality of life, isometric strength, and acceptance of IVR will be also assessed. primaryPurpose: PREVENTION masking: DOUBLE whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 212 type: ESTIMATED name: Virtual reality name: multicomponent exercise measure: Mini-Mental State Examination (MMSE) measure: Isometric handgrip strength sex: ALL minimumAge: 75 Years stdAges: OLDER_ADULT hasResults: False
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<|newrecord|> nctId: NCT06340269 id: PJ2308-0025 briefTitle: Feasibility Pilot Study to Evaluate the Safety and Performance of the MEX-CD1 Medical Device in ACLF acronym: MexACLF overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-03 date: 2025-03 date: 2024-04-01 date: 2024-04-03 name: Mexbrain class: INDUSTRY briefSummary: The goal of this clinical trial is to test the MEX-CD1 hemodialysis medical device in patients suffering from ACLF. The main questions it aims to answer are:
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* Is the device safe when used according to the instructions for use?
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* Does the device work as expected by removing the excess of free copper from the blood?
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Patients will receive 3 MEX-CD1 Slow Low volume CVVHD within 1 week. conditions: Acute on Chronic Liver Failure conditions: Multiple Organ Failure studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: Prospective, national, monocentric, single-arm, open label, feasibility pilot clinical trial. primaryPurpose: TREATMENT masking: NONE count: 10 type: ESTIMATED name: MEX-CD1 Dialysis measure: SADE for Safety purpose measure: SAE for Safety purpose measure: Performance of MEX-CD1 measure: Change in Acute on Chronic Liver Failure (ACLF) Grade measure: Change in CLIF-C ACLF score measure: Improvement in individual organ function measure: Development of secondary infection measure: Status of ICU measure: hospital discharge measure: Mortality sex: ALL minimumAge: 18 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Hôpital Croix Rousse, Service d'hépatologie et gastroentérologie city: Lyon state: Rhône-Alpes zip: 69317 country: France name: Céline GUICHON, MD role: CONTACT phone: +33426109351 email: [email protected] name: Céline Guichon, MD role: PRINCIPAL_INVESTIGATOR lat: 45.74848 lon: 4.84669 hasResults: False
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<|newrecord|> nctId: NCT06340256 id: IRB0000871253 briefTitle: Continuous Spinal Anesthesia Versus Epidural Anesthesia in Geriatric overallStatus: COMPLETED date: 2021-09-18 date: 2023-08-02 date: 2023-08-15 date: 2024-04-01 date: 2024-04-01 name: Assiut University class: OTHER briefSummary: 60 patients aged older than 60 years, American Society of Anesthesiologists (ASA) class II or III and scheduled for major hip surgery will be randomized, in to two groups anesthetized using continuous spinal anesthesia or using continuous epidural anesthesia. conditions: Epidural Catheter studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: HEALTH_SERVICES_RESEARCH masking: SINGLE whoMasked: PARTICIPANT count: 60 type: ACTUAL name: Continuous spinal anesthesia name: Continuous epidural anesthesia measure: Hemodynamic changes measure: Patient satisfaction sex: ALL minimumAge: 60 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Al-Azhar Faculty of Medicine city: Assiut country: Egypt lat: 27.18096 lon: 31.18368 hasResults: False
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<|newrecord|> nctId: NCT06340243 id: HODGKIN briefTitle: Risk Adapted Therapy of Hodgkin Lymphoma in Upper Egypt overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2026-04-01 date: 2026-04-01 date: 2024-04-01 date: 2024-04-01 name: Assiut University class: OTHER briefSummary: determine if radiotherapy could be safely omitted for early hodgkin lymphoma responder patients without compromising outcome conditions: Pediatric Hodgkin Lymphoma studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 50 type: ESTIMATED name: radiotherapy measure: assess the outcome of pediatric patients with HL treated with risk- and response-adjusted therapy sex: ALL minimumAge: 1 Month maximumAge: 18 Years stdAges: CHILD stdAges: ADULT hasResults: False
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<|newrecord|> nctId: NCT06340230 id: BC-NEO-IIT-SHR-A1811-SHR1316 briefTitle: SHR-A1811 Alone or in Combination With Adebrelimab as Neoadjuvant Treatment in ER Positive/HER2 Low Breast Cancer overallStatus: NOT_YET_RECRUITING date: 2024-04-15 date: 2026-02-28 date: 2031-02-28 date: 2024-04-01 date: 2024-04-01 name: Shengjing Hospital class: OTHER name: Jiangsu HengRui Medicine Co., Ltd. briefSummary: This is an open-label, phase II study evaluating the efficacy and safety of SHR-A1811 alone or in combination with Adebrelimab in Stage II-III ER Positive/HER2 Low Breast Cancer. Subjects will receive the neoadjuvant therapy of SHR-A1811 alone or in combination with Adebrelimab for six cycles, and then undergo surgery within 4 weeks after neoadjuvant therapy. Efficacy will be assessed every 2 cycles. conditions: ER Positive/HER2 Low Breast Cancer studyType: INTERVENTIONAL phases: PHASE2 allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 93 type: ESTIMATED name: SHR-A1811 Injection + Adebrelimab Injection name: SHR-A1811 Injection + Adebrelimab Injection name: SHR-A1811 Injection measure: Total pathological complete response (tpCR: ypT0-is/ypN0) measure: Breast pathological complete response (bpCR：ypT0-is) measure: Residual cancer burden (RCB) measure: Best overall response rate (BORR) measure: Overall survival (OS) measure: Disease-free survival (DFS) measure: Event-free survival (EFS) measure: Health-related quality of life (HRQOL) (EORTC QLQ-C30) measure: Health-related quality of life (HRQOL) sex: FEMALE minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Shengjing Hospital affiliated to China Medical University city: Shenyang state: Liaoning zip: 110004 country: China name: Nan Niu, MD role: CONTACT phone: +8618940256668 email: [email protected] name: Caigang Liu, MD role: PRINCIPAL_INVESTIGATOR lat: 41.79222 lon: 123.43278 hasResults: False
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<|newrecord|> nctId: NCT06340217 id: WMT-GDP-RCT briefTitle: Washed Microbiota Transplantation for Diabetic Gastroparesis overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2029-01 date: 2029-07 date: 2024-04-01 date: 2024-04-17 name: The Second Hospital of Nanjing Medical University class: OTHER briefSummary: This is a randomized controlled trial to explore the efficacy and safety of washed microbiota transplantation (WMT) for diabetic gastroparesis (DGP) patients. conditions: Diabetic Gastroparesis studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 46 type: ESTIMATED name: washed microbiota transplantation name: placebo measure: The proportion of DGP with symptom relief after the procedure. measure: The extent of change observed in GCSI of participants; measure: The extent of change observed in Gastroparesis Core Symptom Daily Diary (GCS-DD) of participants; measure: The extent of change observed in Patient Assessment of Upper Gastrointestinal Symptom Severity Index (PAGI-SYM) of participants; measure: The extent of change observed in Patient Assessment of Upper Gastrointestinal Disorders-Quality of Life (PAGI-QoL) of participants; measure: The extent of change observed in electrogastrogram (EGG) of participants; measure: The extent of change observed in electrogastrogram (EGG) of participants; measure: The extent of change observed in gastrointestinal ultrasound (GIUS) of participants; measure: The incidence rate of adverse events; measure: The changes in gut microbiota composition and metabolites before and after treatment. sex: ALL minimumAge: 18 Years maximumAge: 100 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Medical Center for Digestive Diseases, The Second Affiliated Hospital of Nanjing Medical University city: Nanjing state: Jiangsu zip: 210011 country: China lat: 32.06167 lon: 118.77778 hasResults: False
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<|newrecord|> nctId: NCT06340204 id: PKUPH-EWS-03 briefTitle: Weekly Irinotecan Liposomes in Recurrent or Refractory Ewing Sarcoma overallStatus: RECRUITING date: 2024-03-25 date: 2026-03-25 date: 2026-12-25 date: 2024-04-01 date: 2024-04-03 name: Peking University People's Hospital class: OTHER name: Peking University Shougang Hospital name: Shandong Cancer Hospital and Institute briefSummary: The investigators explored the safety and activity of weekly irinotecan liposomes in patients with relapsed and metastatic Ewing Sarcoma. conditions: Ewing Sarcoma studyType: INTERVENTIONAL phases: PHASE1 allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 44 type: ESTIMATED name: Irinotecan Hydrochloride Liposome Injection measure: maximum tolerated dose (MTD) measure: Objective Response Rate (ORR) measure: Progression Free Survival (PFS) sex: ALL minimumAge: 8 Years maximumAge: 40 Years stdAges: CHILD stdAges: ADULT facility: Shandong Cancer Hospital and Institute status: NOT_YET_RECRUITING city: Jina state: Shandong zip: 250117 country: China name: Dongyuan Zhu, M.D. role: CONTACT email: [email protected] facility: Peking University Shougang Hospital status: NOT_YET_RECRUITING city: Beijing zip: 100043 country: China name: Jin GU, M.D. role: CONTACT email: [email protected] lat: 39.9075 lon: 116.39723 facility: Peking University People's Hospital status: RECRUITING city: Beijin zip: 100034 country: China name: Jie Xu, M.D. role: CONTACT phone: +86 15901040835 email: [email protected] name: Xiaodong Tang, M.D. role: PRINCIPAL_INVESTIGATOR name: Lu Xie, M.D. role: SUB_INVESTIGATOR hasResults: False
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<|newrecord|> nctId: NCT06340191 id: UJAPIlates1 briefTitle: Cueing and Pilates in Low Back Pain acronym: PIlatesuja overallStatus: COMPLETED date: 2023-05-02 date: 2024-02-20 date: 2024-02-26 date: 2024-04-01 date: 2024-04-01 name: University of Jaén class: OTHER briefSummary: The intervention involved two groups participating in supervised Pilates sessions, twice a week for 8 weeks, featuring a mix of mat and props-based exercises. Group 1 received additional cueing training to enhance alignment, muscle engagement, and movement technique, while Group 2 underwent the same Pilates regimen without this cueing component. conditions: Low Back Pain conditions: Pilates Exercise conditions: Pilates, Core Stability conditions: Mind-body Exercise studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: TRIPLE whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 67 type: ACTUAL name: Pilates with cueing name: Pilates without cueing measure: Low back pain measure: Pain report measure: Fear of movement measure: Perceived Stress Scale measure: Pain self-efficacy measure: Patient Impression of Change measure: Body Awareness sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of Jaen city: Jaen zip: 23071 country: Spain lat: 37.76922 lon: -3.79028 hasResults: False
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<|newrecord|> nctId: NCT06340178 id: 2024-00246 briefTitle: CT-guided Lung Biopsy Risk Optimization Method acronym: BROM-I overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2026-04-01 date: 2027-04-01 date: 2024-04-01 date: 2024-04-01 name: Insel Gruppe AG, University Hospital Bern class: OTHER briefSummary: The purpose of this randomized controlled study is to evaluate the extent to which injection of a small amount of fluid in the pleural cavity at the biopsy site may reduce the risk of pneumothoraces, in addition to patient positioning to allow biopsy in gravity-dependent areas of the lung. conditions: Pneumothorax conditions: Biopsy, Needle conditions: Risk Factors conditions: Radiology, Interventional studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: DOUBLE whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 198 type: ESTIMATED name: Fluid application during ct-guided lung biopsy measure: Number of patients with pneumothorax measure: Number of patients with bleeding measure: Number of patients with chest tube placement measure: Number of patients with air embolism sex: ALL minimumAge: 18 Years maximumAge: 100 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Inselspital, Bern University Hospital, University of Bern, Freiburgstrasse 10 city: Bern zip: 3010 country: Switzerland lat: 46.94809 lon: 7.44744 hasResults: False
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<|newrecord|> nctId: NCT06340165 id: 2023-KS-151 briefTitle: A Real-world Efficacy and Safety Study of Amlotinib for HER2-negative Advanced Breast Cancer overallStatus: RECRUITING date: 2024-02-04 date: 2025-06 date: 2025-06 date: 2024-04-01 date: 2024-04-01 name: The First Hospital of Jilin University class: OTHER briefSummary: This study analyses the efficacy and safety of amlotinib as a study drug in the treatment of HER-2 negative advanced breast cancer in the real world, including the number of treatment lines, monotherapy, combination therapy, and different molecular subtypes of breast cancer. Evidence-based medicine evidence for clinicians. Although the clinical application of amlotinib in breast cancer treatment is a supra-indication drug, in view of its high safety and possible good efficacy for advanced breast cancer, some patients have been clinically adopted to try the treatment after communicating with their families. This study provides evidence for the further use of amlotinib in breast cancer treatment by analysing the efficacy and safety of amlotinib in real-world applications. conditions: Breast Cancer studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: RETROSPECTIVE count: 153 type: ESTIMATED name: Anlotinib measure: PFS sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: The First Affiliated Hospital of Jilin University status: RECRUITING city: Changchun state: Jilin zip: 130021 country: China name: xu sun role: PRINCIPAL_INVESTIGATOR lat: 43.88 lon: 125.32278 hasResults: False
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<|newrecord|> nctId: NCT06340152 id: 808385 id: U01HG013189-01 type: NIH link: https://reporter.nih.gov/quickSearch/U01HG013189-01 briefTitle: Multi-Omics for Maternal Health After Preeclampsia acronym: MOM-Health overallStatus: RECRUITING date: 2023-12-20 date: 2028-12 date: 2028-12 date: 2024-04-01 date: 2024-04-01 name: University of California, San Diego class: OTHER name: National Human Genome Research Institute (NHGRI) name: Vanderbilt University Medical Center briefSummary: To develop strategies to identify postpartum women at risk for adverse cardiovascular outcomes and provide them with preventative therapies. conditions: Pre-Eclampsia conditions: Pregnancy Induced Hypertension studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 1100 type: ESTIMATED measure: Preeclampsia measure: Gestational hypertension measure: Postpartum hypertension measure: Postpartum cardiovascular disease measure: Other cardiovascular disease sex: FEMALE minimumAge: 18 Years maximumAge: 50 Years stdAges: ADULT facility: University of California, San Diego status: RECRUITING city: San Diego state: California zip: 92037 country: United States name: Samantha La Belle role: CONTACT phone: 858-249-5985 email: [email protected] name: Louise Laurent, MD, PhD role: PRINCIPAL_INVESTIGATOR name: Marni Jacobs, PhD role: PRINCIPAL_INVESTIGATOR lat: 32.71533 lon: -117.15726 hasResults: False
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<|newrecord|> nctId: NCT06340139 id: Riphah/RCRAHS-ISB/REC/01742 briefTitle: Vestibulo-Ocular Reflex for Balance and Stimming in Autism Spectrum Disorder overallStatus: RECRUITING date: 2024-03-20 date: 2024-07-20 date: 2024-08-20 date: 2024-04-01 date: 2024-04-01 name: Riphah International University class: OTHER briefSummary: Autism spectrum disorder is a neurodevelopmental disorder that encompasses a number of disorders specifically affecting social skills, Communication and present with Rapid repetitive behaviors. Autism spectrum disorder also presents with inability of body to process sensory information which can causes symptoms such as balance deficits, sensitivity to certain sounds or an exaggerated reaction to a normal stimulus. Autism spectrum disorder can affect the quality of life of an individual to a severe extent. This disorder due to sensory processing deficits also shows difficulty in motor planning, coordination and execution of tasks which can make performing activities of daily living highly difficult to perform. It is called a developmental disorder because it affects the growth. Milestones are often delayed in individuals with autism. Due to these deficits individual with autism if not provided with therapies at the right age can stay dependent on caretaker for their whole life. Rapid repetitive behaviors also known as self-stimulatory behaviors are a way to compensate with anxiety, difficulty in processing sensory information and are often used to stimulate themselves to feel calm. Though not a diagnostic symptom autism often still presents with vestibular dysfunction which affects the balance. Several individuals with autism have showed abnormal vestibular ocular reflexes; abnormally long latency of saccades. Rehabilitation protocol of Autism often includes symptomatic treatment and several therapy protocols such as physical therapy, occupational therapy, applied behavior analysis therapy and play therapy. conditions: Autism Spectrum Disorder studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 44 type: ESTIMATED name: conventional treatment name: experimental treatment measure: Aberrant behavior checklist measure: Berg Balance Scale (BBS) measure: Repetitive Behavior Scale - Revised measure: Functional Reach Test sex: ALL minimumAge: 13 Years maximumAge: 18 Years stdAges: CHILD stdAges: ADULT facility: zamam autism Centre status: RECRUITING city: Islamabad country: Pakistan name: Rahim Hussain role: CONTACT lat: 33.72148 lon: 73.04329 hasResults: False
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<|newrecord|> nctId: NCT06340126 id: REC/RCR & AHS/23/0567 briefTitle: Effects of Active Tissue Release Techniques on Groin Pain in 2nd Trimester of Pregnancy overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2024-09-20 date: 2024-10-05 date: 2024-04-01 date: 2024-04-01 name: Riphah International University class: OTHER briefSummary: The study will focus on the effects of active tissue release techniques on groin pain, hip range of motion, and functional disability in 2nd trimester of pregnancy. This will be a randomized controlled trial conducted on 30 participants from Prime Care Hospital. Pregnant women in the second trimester aged between 25 to 35 years, who have groin or round ligament pain will be included in this study. A sample of 30 will be divided into 2 groups. Group A will undergo treatment of active release techniques for 10 minutes thrice a week with no home plan of home relaxation exercises. In contrast, Group B will combine treatment of active release technology with home relaxation exercises. Treatment will be given for 4 weeks and pain will be assessed before and after the treatment through (NPRS) scale. Functional disability will be measured before and after the treatment through Quebec scale and Force Disability Scale Questionnaire in both groups. conditions: Groin Strain studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 30 type: ESTIMATED name: Active release techniques name: Relaxation exercises measure: Numeric Pain Rating Scale measure: The Quebec questionnaire: measure: Goniometer: To measure range of motion: sex: FEMALE minimumAge: 25 Years maximumAge: 35 Years stdAges: ADULT facility: Prime Care Hospital city: Faisalābad state: Punjab zip: 38000 country: Pakistan name: Ghulam Fatima, PhD* role: CONTACT phone: 03034073057 email: [email protected] lat: 31.41554 lon: 73.08969 hasResults: False
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<|newrecord|> nctId: NCT06340113 id: REC/RCR & AHS/23/0108 NASHIA briefTitle: Mulligan and Mckenzie Exercises Alongwith Stabilization Exercises in Patients With Chronic Neck Pain overallStatus: RECRUITING date: 2023-11-20 date: 2024-06-01 date: 2024-06-01 date: 2024-04-01 date: 2024-04-03 name: Riphah International University class: OTHER briefSummary: The goal of this \[type of study: Randomized control trial\] is to \[ compare the effectiveness of Mulligan and McKenzie Exercises along with stabilization exercises on pain, range of motion and disability \] in \[ in patients with chronic neck pain\].The main question it aims to answer is:
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* Wether Mulligan is more effective or Mckenzie exercises along with stabilization exercises in the treatment of patients with chronic neck pain Group 1 will recieve Mulligan and stabilization exercises Group 2 will recieve Mckenzie and stabilization exercises conditions: Neck Pain studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 22 type: ESTIMATED name: MCKENZIE AND STABILIZATION EXERCISES name: MULLIGAN AND STABILIZATION EXERCISES measure: Numeric pain rating scale measure: Neck Disability Index (NDI) measure: Goniometer sex: ALL minimumAge: 40 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Riphah international university status: RECRUITING city: Lahore state: Punjab zip: 54000 country: Pakistan name: Muhammad Sanaullah, MS role: CONTACT phone: 03224819253 email: [email protected] lat: 31.558 lon: 74.35071 hasResults: False
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<|newrecord|> nctId: NCT06340100 id: REC/MS-PT/01832 briefTitle: Association of History of Concussion With Vestibular Impairment and Cognitive Function in Sports Athletes overallStatus: RECRUITING date: 2024-03-23 date: 2024-04-23 date: 2024-06-02 date: 2024-04-01 date: 2024-04-01 name: Riphah International University class: OTHER briefSummary: This study investigates the potential relationship between prior concussions and their impact on both vestibular function and cognitive abilities in athletes participating in sports. conditions: Concussion, Mild conditions: Vestibular Impairment conditions: Cognitive Impairment studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: OTHER count: 115 type: ESTIMATED name: find association between vestibular impairment , cognitive fiunction with concussin measure: CANTU measure: Sports concussion office assesment tool 6 sex: ALL minimumAge: 18 Years maximumAge: 36 Years stdAges: ADULT facility: HAYATABAD Sports complex status: RECRUITING city: Peshawar state: Khyber Pakhtun Khawan zip: 24730 country: Pakistan name: Nadia Ishtiaq, MSOMPT role: CONTACT phone: +922486977541 email: [email protected] name: MAHEEN GUL, MSSPT* role: CONTACT phone: +923319533510 name: Maheen Gul, MS*SPT role: PRINCIPAL_INVESTIGATOR lat: 34.008 lon: 71.57849 hasResults: False
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<|newrecord|> nctId: NCT06340087 id: 706014-3 briefTitle: Impact Hesperetin in Combination With Sucrose on Blood Glucose Regulation overallStatus: RECRUITING date: 2024-03-31 date: 2024-08-31 date: 2025-03-31 date: 2024-04-01 date: 2024-04-23 name: University of Vienna class: OTHER briefSummary: The aim of this cross-over intervention study is to investigate the influence of hesperetin applied in combination with sucrose in comparison to an equally sweet-tasting sucrose-only solution and an isocaloric sucrose-only solution on markers of energy metabolism conditions: Blood Glucose Fluctuations conditions: Hunger studyType: INTERVENTIONAL phases: EARLY_PHASE1 allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: BASIC_SCIENCE masking: DOUBLE whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 45 type: ESTIMATED name: 10% Sucrose name: Sucrose+ Hesperetin name: 7% Sucrose measure: Change in blood glucose concentration measure: Change in appetite score measure: Change in food intake measure: Change in regulating hormones sex: ALL minimumAge: 18 Years maximumAge: 45 Years stdAges: ADULT facility: Christian Doppler Laboratory for Taste Research status: RECRUITING city: Vienna zip: 1090 country: Austria name: Barbara Lieder, PhD role: CONTACT phone: +431427770611 email: [email protected] lat: 48.20849 lon: 16.37208 hasResults: False
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<|newrecord|> nctId: NCT06340074 id: STUDY00010282 briefTitle: Helping Educational Leadership Mobilize Evidence acronym: HELM overallStatus: COMPLETED date: 2022-08-28 date: 2023-06-01 date: 2023-06-07 date: 2024-04-01 date: 2024-04-01 name: University of Washington class: OTHER briefSummary: Many universal, evidence-based prevention practices (EBPPs) have been developed to prevent SEB problems, typically in elementary schools, but progress toward widespread implementation has been slow and few efforts have been made to develop and test interventions to enhance EBPP implementation in schools. Schools leaders (e.g., principals) are key to decision making and implementation of EBPPs, and their leadership has been shown to be consistently linked to student outcomes through their intentional efforts to support teacher adoption and use of innovative programs. Helping Educational Leaders Mobilize (HELM) Evidence is a pragmatic, multifaceted, organizationally-focused implementation strategy targeting the implementation leadership and implementation climate of school buildings (through principals) to enhance the adoption and delivery of EBPPs in elementary schools. This pilot study, part of the larger HELM project to adapt and test the strategy based on an existing leadership intervention, Leadership and Organizational Change for Implementation (LOCI), will be implemented in the context of Positive Greetings at the Door (PGD), a universal school-based EBPP previously demonstrated to reduce disruptive behavior and increase academic engagement. conditions: Behavior, Child studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: HEALTH_SERVICES_RESEARCH masking: SINGLE whoMasked: PARTICIPANT count: 333 type: ACTUAL name: HELM name: Implementation Attention Control (IAC) measure: Proximal Outcome: Strategic Implementation Leadership measure: Proximal Outcome: Strategic Implementation Climate measure: Proximal Outcome: Implementation Citizenship Behavior measure: Proximal Outcome: Implementation Initiative Stability measure: Implementation Outcome: Fidelity and Sustainment - Observed measure: Implementation Outcome: Fidelity and Sustainment - Self Report measure: Implementation Outcome: Reach measure: Implementation Outcome: Facilitators and Barriers to Implementation measure: Implementation Outcome: Implementation Cost measure: Student Educational Outcomes measure: Student Behavioral Outcomes sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of Washington School Mental Health Assessment, Research, and Training (SMART) Center city: Seattle state: Washington zip: 98115-8160 country: United States lat: 47.60621 lon: -122.33207 hasResults: False
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<|newrecord|> nctId: NCT06340061 id: Qianyu Wu briefTitle: The Aim of This Study is to Investigate the Correlation Between the Severity of Glaucoma and Corneal Biomechanics as Well as Anterior Chamber Parameters. overallStatus: ACTIVE_NOT_RECRUITING date: 2022-10-20 date: 2024-12-31 date: 2024-12-31 date: 2024-04-01 date: 2024-04-01 name: Henan Provincial People's Hospital class: OTHER briefSummary: The ocular biomechanical differences between the normal control group and primary glaucoma patients, including those treated with conventional medication, laser therapy, and surgery, were compared. Additionally, an investigation was conducted to explore the relationship between anterior chamber parameters, corneal biomechanics, and the severity of glaucoma conditions: Glaucoma studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 80 type: ESTIMATED name: Observational study measure: IOP measure: bIOP measure: ACD measure: ACW measure: SSI measure: VF sex: ALL minimumAge: 22 Years maximumAge: 79 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Henan Provincial People's Hospital city: Zhengzhou state: Henan zip: 450003 country: China lat: 34.75778 lon: 113.64861 hasResults: False
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<|newrecord|> nctId: NCT06340048 id: XC Liu briefTitle: Epicardial Injection of hiPSC-CMs to Treat Severe Chronic Ischemic Heart Failure overallStatus: RECRUITING date: 2023-09-05 date: 2024-09-05 date: 2025-03-05 date: 2024-04-01 date: 2024-04-01 name: Help Therapeutics class: INDUSTRY name: TEDA International Cardiovascular Hospital briefSummary: The purpose of this clinical study is to evaluate the feasibility, safety and efficacy of intramyocardial injection of human induce pluripotent stem cell-derived cardiomyocytes (HiCM-188) during coronary artery bypass grafting (CABG) surgery in patients with severe chronic ischemic heart failure. conditions: Heart Failure studyType: INTERVENTIONAL phases: PHASE1 phases: PHASE2 allocation: NON_RANDOMIZED interventionModel: SEQUENTIAL primaryPurpose: TREATMENT masking: NONE count: 36 type: ESTIMATED name: HiCM-188 therapy measure: The incidence of major Serious Adverse Events (SAE) measure: Grade 4 or above arrhythmias measure: The incidence of tumor measure: Left ventricular geometry as assessed by cardiac magnetic resonance imaging (MRI) measure: Size of myocardial infarction as assessed by MRI measure: Ventricular wall motion as assessed by MRI measure: Left ventricular ejection fraction as assessed by MRI measure: Cardiac Volumes as assessed by MRI measure: Cardiac output (CO) as assessed by MRI measure: 10.End-diastolic myocardial mass as assessed by MRI measure: Left ventricular ejection fraction (LVEF) as assessed by Echocardiography measure: Fractional shortening (FS) as assessed by Echocardiography measure: Left ventricular dimensions as assessed by Echocardiography measure: Cardiac Volumes as assessed by Echocardiography measure: Mitral valve inflow spectrum(E/A) as assessed by Echocardiography measure: Longitudinal strain as assessed by Echocardiography measure: Myocardial viability as assessed by SPECT measure: Myocardial blood flow as assessed by SPECT measure: NT-proBNP Levels measure: 6-minute walking distance measure: New York Heart Association (NYHA) functional classification measure: Changes of Quality of Life (QoL) as assessed by Minnesota Living with Heart Failure Questionnaire (MLHFQ) measure: Changes of Quality of Life(QOL) as assessed by 36-Item Short Form Survey (SF-36) sex: ALL minimumAge: 35 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: TEDA International Cardiovascular Hospital status: RECRUITING city: Tianjin state: Tianjin zip: 300457 country: China name: Xiaocheng Liu role: CONTACT phone: +86-022-65208030 name: Xiaocheng Liu role: PRINCIPAL_INVESTIGATOR lat: 39.14222 lon: 117.17667 hasResults: False
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<|newrecord|> nctId: NCT06340035 id: 20230901 briefTitle: Percutaneous Peripheral Nerve Stimulation of Gluteus Nerves to Improve Hip Strength and Power overallStatus: ACTIVE_NOT_RECRUITING date: 2023-09-01 date: 2024-04 date: 2024-06 date: 2024-04-01 date: 2024-04-01 name: Hospital Clinic of Barcelona class: OTHER briefSummary: The goal of this pilot clinical trial is to evaluate whether the ultrasound-guided percutaneous peripheral nerve stimulation through a needle results in greater gains in strength and power compared to the administration of current through surface electrodes in patients undergoing strength and power assessments. The main questions it aims to answer are:
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Does percutaneous stimulation of the superior and inferior gluteal nerves using ultrasound-guided needles enhance strength and power more effectively than transcutaneous stimulation through electrodes?
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Is the effectiveness of current delivery significantly different between percutaneous and transcutaneous methods when assessed with a linear encoder in a standarized hip extension exercise?
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Participants will:
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Be randomized into two groups: one undergoing ultrasound-guided percutaneous stimulation of the gluteal nerves (experimental group) and the other undergoing transcutaneous stimulation through electrodes (control group).
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The same stimulation protocol at 10 Hz frequency with the maximum muscle contraction evoked without pain will be performed in both groups. Then, the participants will undergo strength and power assessment before and after therapy administration using a linear encoder in a hip extension exercise.
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Researchers will compare the experimental group to the control group to see if the method of current delivery (percutaneous vs. transcutaneous) has a significant impact on the gains in strength and power. This comparison is based on the hypothesis that percutaneous delivery of current, guided by ultrasound, is more effective than simply positioning a surface electrode for transcutaneous stimulation. The evaluation of strength and power will be performed through a linear encoder that measures peak strength and concentric power in each repetition, conducted by a blind operator unaware of the patients' group allocations. conditions: Chronic Pain conditions: Chronic Knee Pain studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: This pilot study utilizes a randomized parallel-group design, focusing on procedure feasibility for future clinical trials, in line with extended CONSORT guidelines for pilot studies. Participants, selected through a convenience sampling method due to their chronic knee pain, received pre- and post-treatment evaluations to assess the effect on gluteal muscle function. Post-informed consent, participants were allocated to either TENS or ultrasound-guided percutaneous nerve stimulation via a computer-generated randomization process executed with GraphPad Software (San Diego, CA, USA), ensuring a balanced 1:1 ratio. primaryPurpose: TREATMENT masking: TRIPLE maskingDescription: In the study, blinding will be implemented to minimize bias. The evaluating clinician will be blinded to participant group assignments, ensuring assessments are unbiased. Similarly, the data analyst will also be blinded, analyzing data without knowledge of group allocations to maintain impartiality. Data will be handled objectively, with statistical methods applied blindly to compare treatment groups. Despite challenges in completely blinding participants due to the distinct nature of interventions, every effort will be made to minimize potential bias. whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 12 type: ACTUAL name: TENS name: Percutaneous Peripheral Nerve Stimulation measure: Hip Extension Concentric Peak Power (Watts) measure: Hip Extension Concentric Peak Strength (Newtons) measure: Concentric Phase Velocity (m/s) measure: Maximum Strength (1RM in kgs) sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of Barcelona city: Barcelona zip: 08036 country: Spain lat: 41.38879 lon: 2.15899 hasResults: False
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<|newrecord|> nctId: NCT06340022 id: 2022-31 briefTitle: Pain and Anxiety Levels of Sleeperone Electronic Anesthesia System in Pediatric Patients overallStatus: COMPLETED date: 2023-03-13 date: 2023-10-02 date: 2023-11-15 date: 2024-04-01 date: 2024-04-01 name: Eskisehir Osmangazi University class: OTHER briefSummary: The conventional method used for dental anesthesia in children is the administration of a local anesthetic solution by injection. Although this process successfully eliminates pain during the procedure, it continues to be a problem for many children in terms of dental anxiety before and during anesthesia administration.
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The aim of this study is to compare intraosseous anesthesia with SleeperOne® 5, a computer-assisted local anesthesia system, with conventional local anesthesia techniques in terms of pain and anxiety. conditions: Dental Anxiety conditions: Pain studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER interventionModelDescription: The study was a single-center randomized controlled trial using a split mouth design with a 1:1 split ratio. primaryPurpose: OTHER masking: NONE count: 32 type: ACTUAL name: Children's Fear Survey Schedule-Dental Subscale (CFSS-DS) scale name: Face Image Scale (FIS) scoring system name: Visual Analogue Scale (VAS) name: pulse rate measure: The pulse rate measurements before and after the anesthesia techniques measure: Determine the anxiety level before the procedures measure: The anxiety measurements before and after the anesthesia techniques measure: The pain measurements during the anesthesia techniques sex: ALL minimumAge: 8 Years maximumAge: 12 Years stdAges: CHILD facility: Eskisehir Osmangazi University Faculty of Dentistry, Department of Pediatric Dentistry city: Eskişehir country: Turkey lat: 39.77667 lon: 30.52056 hasResults: False
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<|newrecord|> nctId: NCT06340009 id: REC/01743 briefTitle: MIME THERAPY vs MOTOR IMAGERY TECHNIQUE in Bell's Palsy overallStatus: RECRUITING date: 2024-03-22 date: 2024-08-22 date: 2024-08-25 date: 2024-04-01 date: 2024-04-01 name: Riphah International University class: OTHER briefSummary: Bell's palsy, characterized by unilateral paralysis/paresis of facial muscles, is a condition with a significant impact on individuals' lives. It was first identified by scientist Sir Charles Bell, and its sudden onset can lead to social, psychological, and emotional distress. Left untreated, Bell's palsy can have long-lasting effects on a patient's quality of life, including loss of facial muscle control, emotional stress, and communication difficulties. Rehabilitation protocols encompass various physical therapy techniques, among which Mime therapy and Motor imagery technique have shown promise. conditions: Bell Palsy studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 44 type: ESTIMATED name: mime therapy name: motor imagery measure: House-Brackmann Scale (HBS) measure: Facial Disability Index (FDI) measure: Sunnybrook Facial Grading System measure: Synkinesis Assessment Questionnaire (SAQ) sex: ALL minimumAge: 20 Years maximumAge: 40 Years stdAges: ADULT facility: Muzaffar Hospital status: RECRUITING city: Sargodha country: Pakistan name: Mulazam Imran, MS-NMPT* role: CONTACT lat: 32.08361 lon: 72.67111 hasResults: False
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<|newrecord|> nctId: NCT06339996 id: KSVGH24-CT1-10 briefTitle: Male Supplements for Sperm Quality and Aging overallStatus: RECRUITING date: 2024-03-26 date: 2024-03-30 date: 2024-09-30 date: 2024-04-01 date: 2024-04-02 name: Kaohsiung Veterans General Hospital. class: OTHER briefSummary: This study investigates the effects of a new supplement on sperm quality in men with poor sperm quality. Fifty patients will receive the supplement for three months, followed by semen analysis and assessment of sperm aging and mitochondrial function. Changes in sexual function and aging symptoms will also be evaluated. conditions: Unrecognized Condition studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 50 type: ESTIMATED name: Male supplement measure: Semen analysis measure: oxygen consumption of mitochondria measure: mitochondrial function measure: sexual function measure: aging symptoms sex: MALE minimumAge: 30 Years maximumAge: 50 Years stdAges: ADULT facility: Kaohsiung Veterans General Hospital status: RECRUITING city: Kaohsiung country: Taiwan name: Li-Te Lin role: CONTACT phone: +88673464027 email: [email protected] name: Kuan-Hao Tsui role: CONTACT lat: 22.61626 lon: 120.31333 hasResults: False
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<|newrecord|> nctId: NCT06339983 id: REC/RCR & AHS/23/0566 briefTitle: Effects of Scar Mobilization Versus Myofascial Cupping Technique on Cesarean Scar overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2024-09-20 date: 2024-10-05 date: 2024-04-01 date: 2024-04-01 name: Riphah International University class: OTHER briefSummary: Study focuses on comparing the effects of manual scar mobilization and myofascial cupping techniques on the outcomes of pain, physical characteristics, and appearance of cesarean scars. The study aims to contribute valuable insights into tailored interventions for improving cesarean scars. The randomized clinical trial will involve 52 participants, primigravida women aged 20 to 40 with completely healed but painful cesarean scars. Excluding those with previous scar therapy or infectious scars, the participants will be divided into two groups, with Group A receiving manual scar mobilization therapy and Group B receiving myofascial cupping therapy, both administered twice a week for four weeks. Pain assessment will be conducted using a numeric pain rating scale (NPRS), while physical characteristics and appearance will be evaluated using the Manchester Scar Scale for cesarean scars (MSS). The data collected will be analyzed using SPSS version 29. conditions: Cesarean Section; Complications, Wound, Hematoma studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 52 type: ESTIMATED name: Manual Scar Mobilization Therapy: name: Myofascial Cupping Therapy: measure: Numeric Pain Rating Scale measure: Manchester Scar Scale (MSS) sex: FEMALE minimumAge: 20 Years maximumAge: 40 Years stdAges: ADULT facility: Kulsoom Shoukat Medical Complex city: Faisalābad state: Punjab zip: 3800 country: Pakistan name: Ghulam Fatima, PhD* role: CONTACT phone: 03034073057 email: [email protected] lat: 31.41554 lon: 73.08969 hasResults: False
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<|newrecord|> nctId: NCT06339970 id: REC/RCR & AHS/23/0199 iram briefTitle: Effects of Slider Versus Tensioners Nerve Gliding in Cervical Radiculopathy. overallStatus: RECRUITING date: 2023-11-23 date: 2024-06-01 date: 2024-06-01 date: 2024-04-01 date: 2024-04-01 name: Riphah International University class: OTHER briefSummary: This study will be a randomized clinical trial in which Slider versus Tensioners Nerve Gliding Technique along with Mulligan Spinal Mobilization will be applied on the individuals with cerviculorediculopathy and changes will be recorded using different methods and tools. Convenient sampling technique will be used to collect the data. The sample size of 40 patients will be recruited. Patients will be randomly allocated into two different groups through sealed envelope method.20 patients will be allocated in each group A will be treated with Slider Nerve Gliding Technique along with Mulligan Spinal Mobilization Technique; Group B will be treated with Tensioners Nerve Gliding Technique along with Mulligan Spinal Mobilization Technique .Numeric Pain Rating Scale (NPRS), Neck Disability Index (NDI) and goniometer will be used as Data collecting tools. After data collection from defined study setting, data will be entered and analyzed. conditions: Cervical Radiculopathy studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 42 type: ESTIMATED name: Slider Nerve Gliding Technique along with Mulligan Spinal Mobilization Technique name: Tensioners Nerve Gliding Technique along with Mulligan Spinal Mobilization Technique measure: Numeric Pain Rating Scale measure: Neck disability index measure: Goniometer sex: ALL minimumAge: 20 Years maximumAge: 60 Years stdAges: ADULT facility: Sehat Medical Compolex status: RECRUITING city: Lahore state: Punjab zip: 54000 country: Pakistan name: Iram Dalawar, DPT role: CONTACT phone: 03056087141 email: [email protected] name: Iram Dalawar role: PRINCIPAL_INVESTIGATOR lat: 31.558 lon: 74.35071 hasResults: False
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<|newrecord|> nctId: NCT06339957 id: STUDY00006394 briefTitle: Rheumatology Diet Study overallStatus: RECRUITING date: 2024-03-01 date: 2024-07-01 date: 2024-07-01 date: 2024-04-01 date: 2024-04-01 name: University of Central Florida class: OTHER briefSummary: This study aims to collect information on rheumatology patients' dietary habits, autoimmune disease activity, dietary changes, disease symptom improvements, and perceptions on their dietary habits and how it affects their autoimmune disease. The main objective is to see if rheumatology patients change their dietary habits after their diagnosis of an autoimmune disease and if it subjectively improved their disease symptoms. It will also look at rheumatology patients' expectations for their rheumatologist when it comes to dietary advice and what resources they used to choose their new dietary habits. The study also seeks to measure the interest that rheumatology patients have in pursuing dietary changes as a means of controlling the symptoms of their autoimmune disease. It is expected that patients who changed their eating habits to healthier diets such as a Mediterranean diet would report less severe autoimmune disease symptoms. There are limited dietary recommendations for the management of many rheumatological diseases, so this study seeks to assess rheumatology patients' willingness to try dietary modifications, what improvements they had, and why they decide to make these changes in light of limited information. conditions: Diet Habit conditions: Rheumatologic Disease conditions: Autoimmune Diseases conditions: Rheumatoid Arthritis conditions: Psoriatic Arthritis conditions: Ankylosing Spondylitis conditions: Dermatomyositis/Polymyositis conditions: Sjogren's Syndrome conditions: Systemic Lupus Erythematous conditions: Scleroderma conditions: Fibromyalgia studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: CROSS_SECTIONAL count: 500 type: ESTIMATED measure: To determine how diet habits and activity affects autoimmune diseases using the proper statistical tests for the data set such as t-test and ANOVA. measure: To identify if rheumatology patients change their dietary habits after their diagnosis of an autoimmune disease and if it subjectively improved their disease symptoms. sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: UCF Health Clinics status: RECRUITING city: Orlando state: Florida zip: 32827 country: United States lat: 28.53834 lon: -81.37924 hasResults: False
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<|newrecord|> nctId: NCT06339944 id: REC/RCR& AHS/23/0198RubabTalib briefTitle: Effects of Sensory Motor Training and Kinesthetic Exercises in Knee Osteoarthritis. overallStatus: RECRUITING date: 2023-11-23 date: 2024-06-01 date: 2024-06-01 date: 2024-04-01 date: 2024-04-03 name: Riphah International University class: OTHER briefSummary: In this study i will see the effects of kinesthetic exercises and sensory motor training on pain and range of motion in patients with knee OA. conditions: Knee Osteoarthritis studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 34 type: ESTIMATED name: sensory motor training name: kinesthetic exercises measure: VAS measure: goniometer measure: WOMAC questionaire measure: joint position sense test sex: ALL minimumAge: 40 Years maximumAge: 60 Years stdAges: ADULT facility: Tariq Hospital status: RECRUITING city: Sheikhupura state: Punjab zip: 39350 country: Pakistan name: Rubab Talib, MS role: CONTACT phone: 03040442101 email: [email protected] lat: 31.71306 lon: 73.97833 hasResults: False
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<|newrecord|> nctId: NCT06339931 id: REC/RCR &AHS/23/0181 briefTitle: Lumber Spine Mobilization and Spinal Traction on Lumber Radiculopathy. overallStatus: RECRUITING date: 2023-11-23 date: 2024-06-01 date: 2024-06-01 date: 2024-04-01 date: 2024-04-01 name: Riphah International University class: OTHER briefSummary: Lumber radiculopathy, also known as sciatica, is a condition that causes pain in the lower back and legs due to irritation or compression of the spinal nerves. group between 20 and 50 years old. This study will explore the effects of lumbar spine mobilization with leg movement and spinal traction with and without belt in patients with pain and functional limitations due to lumbar radiculopathy. A randomized control trial will be conducted at Atta Jaspal Hospital and Trauma Center through convenient sampling technique on 44 patients, which will be allocated through simple random sampling through sealed opaque envelopes into groups A and B. Group A will be treated with SMWLM, conventional electrotherapy, and traction without a belt, and Group B will be treated with SMWL, conventional electrotherapy, and lumbar traction with a belt. A pretreatment baseline will be set for pain, ROM, and disability at the lumbar spine by using the NPRS, inclinometer, and ODI questioner. Follow-up will be conducted after 4 weeks of post-treatment sessions. The intensity of pain, range of motion, and disability index will be evaluated using the NPRS, inclinometer, and ODI questionnaire. The data will be analyzed using SPSS software version 26. The conclusion of the study will be based on either accepting or rejecting the null and alternate hypotheses. conditions: Lumbar Radiculopathy studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 44 type: ESTIMATED name: SMWLM combined Spinal traction with belt name: SMWLM combined spinal traction without belt measure: Numeric pain rating scale measure: Inclinometer measure: Oswestry Disability Index sex: ALL minimumAge: 20 Years maximumAge: 50 Years stdAges: ADULT facility: Atta Jaspal Hospital and ortho trauma center status: RECRUITING city: Bhalwal state: Punjab zip: 40410 country: Pakistan name: Azka Ijaz, DPT role: CONTACT phone: 03171742917 email: [email protected] name: Azka Ijaz, DPT role: PRINCIPAL_INVESTIGATOR lat: 32.26576 lon: 72.89809 hasResults: False
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<|newrecord|> nctId: NCT06339918 id: REC/RCR & AHS/23/0570 briefTitle: Combined Effects of Kegel Exercises and 4-7-8 Breathing Technique in Primary Dysmenorrhea overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2024-09-20 date: 2024-10-05 date: 2024-04-01 date: 2024-04-03 name: Riphah International University class: OTHER briefSummary: A randomized clinical trial will be conducted at Riphah International University QIE Campus in Lahore, using non-probability convenience sampling with 28 participants. Criteria include women aged 14-26, nulliparous, experiencing primary dysmenorrhea, with normal menstrual cycles and the ability to exercise independently. Group A will receive kegel exercises and 4-7-8 breathing techniques over 8 weeks, while Group B will only receive the breathing technique. Assessments will be done on menstrual cycle days, with follow-ups at weeks 4 and 8 using specific scales. Data will be analyzed using SPSS version 27. conditions: Primary Dysmenorrhea studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 28 type: ESTIMATED name: KegelExercise name: 4-7-8 breathing technique measure: Numeric Pain Rating Scale measure: WALIDD Primary Dysmenorrhea Intensity Scale measure: Pain Self-Efficacy Questionnaire (PSEQ) sex: FEMALE minimumAge: 14 Years maximumAge: 26 Years stdAges: CHILD stdAges: ADULT facility: Riphah International University Clinic city: Lahore state: Punjab zip: 54700 country: Pakistan name: Ghulam Fatima role: CONTACT phone: +923034073057 email: [email protected] lat: 31.558 lon: 74.35071 hasResults: False
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<|newrecord|> nctId: NCT06339905 id: 10840098-772.02-5564 briefTitle: The Effects of EndoActivator on Postoperative Pain and Root Canal Treatment Success overallStatus: COMPLETED date: 2022-01-01 date: 2022-08-31 date: 2023-08-31 date: 2024-04-01 date: 2024-04-01 name: Istanbul Medipol University Hospital class: OTHER briefSummary: This study evaluates postoperative pain and radiographic healing of asymptomatic posterior teeth with chronic apical periodontitis following root-canal treatment performed using EndoActivator for irrigation activation. conditions: Periapical Periodontitis conditions: Root Canal Infection studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: FACTORIAL primaryPurpose: TREATMENT masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 140 type: ACTUAL name: Sonic Activation with EndoActivator name: Control Needle Irrigation measure: change from baseline postoperative pain at 1 week measure: change from baseline periapical index at 1 year sex: ALL minimumAge: 18 Years maximumAge: 60 Years stdAges: ADULT facility: Istanbul Medipol University, Faculty of Dentistry city: Istanbul state: Esenler country: Turkey lat: 41.01384 lon: 28.94966 hasResults: False
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<|newrecord|> nctId: NCT06339892 id: 2022-3.11/451 briefTitle: HCMV Breakthrough Infections During Letermovir Prophylaxis acronym: CMVbreak overallStatus: RECRUITING date: 2023-01-09 date: 2025-06 date: 2026-03 date: 2024-04-01 date: 2024-04-01 name: Foundation IRCCS San Matteo Hospital class: OTHER name: Ministero della Salute, Italy briefSummary: The goal of this clinical trial is to compare two strategies to monitor human cytomegalovirus (HCMV) infections in transplanted patients receiving letermovir (LTV) as anti-HCMV prophylaxis.
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HCMV infection after transplantation is diagnosed by detection of HCMV DNA in blood. However, due to the peculiar mechanism of action of LTV, most episodes of HCMV DNA detection are caused by release in the blood stream of non-infectious HCMV DNA.
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In true episodes of productive infection, HCMV DNA in blood is present inside the virion and therefore is resistant to DNAse digestion. Conversely, when non-infectious free-floating HCMV DNA is released in the bloodstream, it will be degraded after treatment of plasma with DNAse and will not be detectable by real-time PCR assays.
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Researchers will compare determination of HCMV DNA in blood with or without previous digestion of non-infectious free-floating DNA with DNAse.
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In patients of the Control group HCMV DNA will be tested without DNAse digestion. If HCMV DNA is positive, patients will stop LTV prophylaxis and receive antiviral therapy with another drug.
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In patients of the Study group HCMV DNA will be tested after DNAse digestion. Only if HCMV DNA is positive after DNAse digestion, patients will stop LTV prophylaxis and receive antiviral therapy with another drug.
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The main aim of the study is to demonstrate that, by avoiding inappropriate antiviral therapy during LTV prophylaxis, transplant patients will suffer of lower antiviral-drug-related toxicity. A monitoring strategy able to identify true episodes of HCMV productive infection during LTV prophylaxis will lead to a lower rate of inappropriate antiviral therapy and drug-related toxicity without an increased risk of HCMV disease. conditions: Cytomegalovirus Infections conditions: Cytomegalovirus Viremia conditions: Hematopoietic Stem Cell Transplantation studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: DIAGNOSTIC masking: NONE count: 140 type: ESTIMATED name: Determination of HCMV DNA in plasma after DNAse digestion. name: Determination of HCMV DNA in blood or plasma. measure: - Proportion of patients with positive HCMV DNAemia developing antiviral drug-related toxicity. measure: Proportion of patients developing HCMV DNAemia during LTV prophylaxis. measure: Proportion of patients developing HCMV disease within day 100 and between day 100 and 360 from transplant (key secondary endpoint) measure: Proportion of patients stopping LTV prophylaxis and shifting to GCV/VGCV/FOS therapy. measure: Proportion of patients requiring GCV/VGCV/FOS therapy between day 100 and 360. measure: Proportion of patients with persisting HCMV DNAemia. measure: Proportion of patients developing neutropenia between day 100 and 360. measure: Proportion of patients developing HCMV-specific T-cell response at day 100, 180, and 360. measure: Proportion of patients developing LTV-resistant HCMV strains. measure: Cumulative incidence of acute or chronic GvHD. measure: Transplant related mortality (TRM), underlying disease relapse, and 1-year survival. sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: ASST-Spedali Civili status: RECRUITING city: Brescia state: BS country: Italy name: Michele Malagola, MD role: CONTACT lat: 45.53558 lon: 10.21472 facility: Fondazione IRCCS Policlinico San Matteo status: RECRUITING city: Pavia state: PV zip: 27100 country: Italy name: Daniele Lilleri, MD role: CONTACT phone: +39 0382 502420 email: [email protected] name: Irene Cassaniti, PhD role: CONTACT phone: +39 0382 502420 email: [email protected] lat: 45.19205 lon: 9.15917 facility: ASST-Ospedale Papa Giovanni XXIII status: NOT_YET_RECRUITING city: Bergamo country: Italy name: Alessandra Algarotti, MD role: CONTACT lat: 45.69601 lon: 9.66721 facility: IRCCS Azienda Ospedaliero-Universitaria di Bologna status: NOT_YET_RECRUITING city: Bologna country: Italy name: Francesca Bonifazi, MD role: CONTACT lat: 44.49381 lon: 11.33875 facility: ASST Grande Ospedale Metropolitano Niguarda status: NOT_YET_RECRUITING city: Milano country: Italy name: Arianna Pani, MD role: CONTACT lat: 45.46427 lon: 9.18951 facility: Grande Ospedale Metropolitano "Bianchi-Melacrino-Morelli" status: NOT_YET_RECRUITING city: Reggio Calabria country: Italy name: Barbara Loteta, MD role: CONTACT lat: 38.11047 lon: 15.66129 facility: AOU Policlinico Umberto I status: NOT_YET_RECRUITING city: Roma country: Italy name: Corrado Girmenia, MD role: CONTACT lat: 41.89193 lon: 12.51133 facility: Policlinico Universitario Agostino Gemelli status: NOT_YET_RECRUITING city: Roma country: Italy name: Patrizia Chiusolo, MD role: CONTACT lat: 41.89193 lon: 12.51133 hasResults: False
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<|newrecord|> nctId: NCT06339879 id: IRB-2023-1071 briefTitle: Health Effects of Grain Foods in Adults overallStatus: RECRUITING date: 2024-01-18 date: 2026-06-30 date: 2026-12-31 date: 2024-04-01 date: 2024-04-04 name: Purdue University class: OTHER name: Grain Food Foundation briefSummary: This study will assess the effects of eating whole grain foods versus refined grain foods with different amounts of added sugar. It is hypothesized that a diet including grain products will have beneficial effects on taste hedonics, appetite, food/energy intake, body weight, blood pressure, acute and chronic glycemia and acute and chronic lipemia compared to customary diets controlling for added sugars, saturated fats and sodium. conditions: High Whole Grain and Low Sugar conditions: Medium Whole Grain and Low Sugar conditions: Low Whole Grain and Low Sugar conditions: Low Whole Grain and High Sugar studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Parallel assignment primaryPurpose: BASIC_SCIENCE masking: NONE count: 120 type: ESTIMATED name: High Whole Grain, Low Sugar name: Low Whole Grain, Low Sugar name: High Whole Grain, High Sugar name: Low Whole Grain, High Sugar measure: Glycemia measure: Appetite measure: Taste Hedonics measure: Energy Intake measure: Body Weight measure: Systolic and Diastolic Blood Pressure measure: Lipemia sex: ALL minimumAge: 21 Years maximumAge: 60 Years stdAges: ADULT facility: Purdue University status: RECRUITING city: West Lafayette state: Indiana zip: 17907 country: United States name: Richard D Mattes, PhD role: CONTACT phone: 765-494-0662 email: [email protected] name: Richard D Mattes, PhD, RD, MPH role: PRINCIPAL_INVESTIGATOR lat: 40.42587 lon: -86.90807 hasResults: False
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<|newrecord|> nctId: NCT06339866 id: E16734702 briefTitle: The Effect of Two Different Video Showings on Pain and Anxiety in Children Undergoing Adenotonsillectomy overallStatus: ACTIVE_NOT_RECRUITING date: 2023-06-25 date: 2024-06-25 date: 2024-06-25 date: 2024-04-01 date: 2024-04-02 name: Zonguldak Bulent Ecevit University class: OTHER briefSummary: Purpose of the Research: The purpose of the research is to examine the effect of two different video presentations on pain and anxiety in children undergoing adenotonsillectomy.
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Type of Research It is planned as a randomized controlled interventional type study to examine the effects of two different video presentations on pain and anxiety in children undergoing adenotonsillectomy. conditions: Pain After Adenotonsillectomy studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: SEQUENTIAL interventionModelDescription: The population of the research will be all patients who had adenotonsillectomy surgery between the ages of 6-12 in the Ear Nose and Throat Service of Zonguldak Bülent Ecevit University Hospital, and the sample will be all patients who had adenotonsillectomy surgery between the specified dates and who meet the inclusion criteria. primaryPurpose: HEALTH_SERVICES_RESEARCH masking: SINGLE whoMasked: PARTICIPANT count: 120 type: ACTUAL name: The Effect of Two Different Video Interventions on Pain and Anxiety in Children with Adenotonsillectomy: A Randomized Controlled Study measure: After the intervention, the mean score of the children in the postoperative animation and cartoon group on the Wong Baker Pain Rating Scale will be lower than those in the control group. measure: After the intervention, the mean score of the Children's Anxiety Scale-Stability score of the children in the postoperative animation and cartoon group will be less than those in the control group. sex: ALL minimumAge: 6 Years maximumAge: 12 Years stdAges: CHILD facility: Mihriye city: Zonguldak zip: 67600 country: Turkey lat: 41.45139 lon: 31.79305 hasResults: False
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<|newrecord|> nctId: NCT06339853 id: 1-2023-0023 briefTitle: Study of Efficacy of Digital Cognitive Behavioral Therapy With Wearable Device for Insomnia overallStatus: COMPLETED date: 2023-09-07 date: 2024-02-29 date: 2024-02-29 date: 2024-04-01 date: 2024-04-01 name: Yonsei University class: OTHER briefSummary: The purpose of the study was to examine safety and efficacy of cognitive behavioral therapy (CBT)-based wearable integrated digital therapeutics for insomnia patients conditions: Insomnia studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 30 type: ACTUAL name: WELT-IP with wearable devices (Apple/galaxy watch. Oura ring) measure: Change from baseline to week 9 (post-treatment) of ISI measure: Secondary Outcome - Changes from baseline to week 9 of SE measure: Changes from baseline to week 9 of SOL. measure: Changes from baseline to week 9 of WASO. measure: Changes from baseline to week 9 of PHQ-9. measure: Changes from baseline to week 9 of GAD-7. measure: Changes from baseline to week 9 of compliance. sex: ALL minimumAge: 19 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Department of Psychiatry, Severance Hospital city: Seoul, zip: 120-752 country: Korea, Republic of lat: 37.566 lon: 126.9784 hasResults: False
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<|newrecord|> nctId: NCT06339840 id: 2024-036-01 briefTitle: The Impact of Lifestyle Intervention on Weight and Fertility in Obese Males overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2024-12-31 date: 2027-03-31 date: 2024-04-01 date: 2024-04-01 name: Third Affiliated Hospital of Zhengzhou University class: OTHER briefSummary: Obesity, defined by WHO standards as having a body mass index (BMI) equal to or greater than 30 kg/m², affects approximately 800 million people worldwide. It is evident that obesity has become a serious public health issue, resulting in significant health burdens.
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Previous systematic reviews have indicated an association between obesity and male factor infertility. In populations undergoing assisted reproductive technology (ART), some studies have shown a correlation between increased male BMI and adverse ART outcomes. Furthermore, the negative effects of obesity may also be transmitted to offspring through genetic and epigenetic changes in reproductive cell DNA, increasing their risk of obesity, metabolic diseases, or other chronic conditions.
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Currently, there is a lack of data on the impact of weight loss in obese men on fertility, and it is unclear which nutritional pattern in lifestyle interventions can more effectively control weight, improve semen quality, and address related endocrine issues in obese men, thereby improving reproductive treatment outcomes.
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