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* Whether the repetitive negative thinking can be used to predict i. initial symptom severity, and ii. therapy outcome (measured by change in scores on disorder specific measures). |
* Whether change in RTQ mediates change in outcome Participants are sent weekly questionnaires that measure their progress. Within these questionnaires are the RTQ and other disorder-specific measures that we will be analysing. |
Researchers may also compare clients with different disorders to see the accuracy the RTQ can predict treatment outcomes for each disorder. conditions: Anxiety Disorders conditions: Obsessive-Compulsive Disorder conditions: Post-traumatic Stress Disorder conditions: Social Anxiety Disorder conditions: Specific Phobia conditions: Panic Disorder conditions: Body Dysmorphic Disorders studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 320 type: ACTUAL measure: Change in Repetitive Ruminative Thinking Questionnaire score measure: Change in disorder-specific measure score sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Centre for Anxiety Disorders and Trauma city: London zip: SE5 8AZ country: United Kingdom lat: 51.50853 lon: -0.12574 hasResults: False |
<|newrecord|> nctId: NCT06370546 id: 229/2022 briefTitle: Cardiac Response to Strength Training in Hypertensive Individuals overallStatus: RECRUITING date: 2023-03-20 date: 2024-07-20 date: 2024-07-20 date: 2024-04-17 date: 2024-04-25 name: Universidad Católica del Maule class: OTHER briefSummary: This study aims to determine the acute and chronic effects of high and low-intensity strength training on cardiac autonomic control in hypertensive subjects conditions: Physical Exercise conditions: Hypertension studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Randomized clinical trial, single blinded. primaryPurpose: TREATMENT masking: NONE count: 28 type: ESTIMATED name: Low intensity name: high intensity measure: Heart rate variability measure: Blood pressure systolic measure: Blood pressure diastolic measure: Blood pressure mean measure: Heart Rate sex: ALL minimumAge: 30 Years maximumAge: 60 Years stdAges: ADULT facility: Universidad Católica del Maule status: RECRUITING city: Talca state: Maule zip: 3469001 country: Chile name: Luis Benavides Roca, PhD(c) role: CONTACT phone: +5699926 8137 email: [email protected] name: Luis Benavides Roca, PhD(c) role: PRINCIPAL_INVESTIGATOR lat: -35.4264 lon: -71.65542 hasResults: False |
<|newrecord|> nctId: NCT06370533 id: HGWG-pro briefTitle: Healthy Gestational Weight Gain Programme overallStatus: NOT_YET_RECRUITING date: 2024-04-15 date: 2025-01-31 date: 2026-01-31 date: 2024-04-17 date: 2024-04-19 name: Peking University class: OTHER name: W.F. Maternal and Child Health Hospital briefSummary: This study aims to evaluate the efficacy of a multi-component lifestyle interventions during pregnancy on promoting appropriate gestational weight gain, preventing GDM, and improving pregnancy, delivery, and neonatal outcomes among overweight or obese pregnant women. The intervention strategies are developed based on the transtheoretical model and mobile health (via WeChat Public Account in smartphone), and will be conducted online and offline. This study will recruit and follow-up 200 overweight or obese singleton pregnant women (pre-pregnancy BMI≥24 kg/m2) during the first trimester of pregnancy from Weifang maternal and Child Health Center, Shandong Province, China. The 200 overweight or obese pregnant women will be randomly allocated at a 1:1 ratio to either the intervention or control group, stratified by the categorical variables of age, BMI and parity. Participants in the control group will be provided usual prenatal care. The lifestyle intervention will last for approximately 6 months (from 10-14 weeks to 32-36 weeks of gestation). Follow-up timepoints included 10-14 weeks of gestation,24-28 weeks of gestation,32-36 weeks of gestation. The interventions are composed of health education related to gestational weight gain and healthy lifestyles, diet modification, active physical activity, regular individual in-person and telephone sessions, diet behavior monitoring, physical activity monitoring, and weight monitoring with Huawei smart watch. The hypothesis is that lifestyle interventions based on the transtheoretical model and mobile health will result in more appropriate gestational weight gain and lower risk of adverse pregnancy outcomes compared with usual care. conditions: Gestational Weight Gain conditions: Overweight and Obesity studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 200 type: ESTIMATED name: behavioral interventions measure: Total gestational weight gain measure: Gestational weight gain before OGTT screening measure: Weekly rate of gestational weight gain between study clinical assessments measure: Proportion of women who exceed the Chinese reference/2009 IOM guidelines for total gestational weight gain measure: Proportion of women who exceed the Chinese reference/2009 IOM guidelines for appropriate weekly rate of GWG in second and third trimester measure: Proportion of women who exceed the Chinese reference/2009 IOM guidelines for appropriate weekly rate of GWG before OGTT screening measure: Rate of Gestational Diabetes Mellitus diagnosed according to International Association of Diabetes and Pregnancy Study Group (IADPSG) criteria measure: Rate of Preeclampsia/Gestational hypertension measure: Rate of Cesarean Section measure: Absolute/Mean Infant birth weight measure: Rate of Macrosomia measure: Absolute/Mean Apgar scores at 1 min or 5 min measure: Change of Blood pressure measure: Change of body fat percentage (%) measure: Change of fat free mass (kg) measure: Change of muscle mass (kg) measure: Change of handgrip strength (kg) measure: Change of Attitude and knowledge measure: Change of dietary intake measure: Change of physical activity measure: Change of sleep quality measure: Change of Quality of life (12-Item Short Form Survey, SF-12) measure: Incidence of depression measure: Incidence of anxiety measure: The Change of Self-efficacy score (General Self-Efficacy Scale, GSES) measure: The stage of change related to gestational weight control behavior measure: Rate of Postpartum weight retention measure: Absolute/mean offspring weight in kilograms measure: Absolute/mean offspring height in centimetres measure: Absolute/mean offspring head circumference sex: FEMALE minimumAge: 18 Years maximumAge: 40 Years stdAges: ADULT hasResults: False |
<|newrecord|> nctId: NCT06370520 id: 123 briefTitle: Screening Emotions in Adolescents at the Hospital for mTBI acronym: SEARCH-mTBI overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2028-09 date: 2028-12 date: 2024-04-17 date: 2024-04-23 name: University of California, Davis class: OTHER name: Pediatric Emergency Care Applied Research Network briefSummary: The goal of this observational study is to develop and validate a clinical tool to predict which adolescents aged 11 to less than 18 years of age with mild traumatic brain injury (mTBI) are at an increased risk for developing significant new or worsening mental health conditions. |
The main aims the study wish to answer are: |
* Does the adolescent have new or worsening depression or anxiety defined as a change from their previous medical history using self-reported questionnaires at either one or three months post-injury? |
* Does the adolescent have unmet mental health care needs, defined as not receiving any mental or behavior health care in patients with new or worsening anxiety or depression as defined by the self reported questionnaires? |
Participants will be enrolled after being diagnosed in the emergency department (ED) with an mTBI. During the ED visit, the child's parent/caregiver and the adolescent will complete several questionnaires related to mental health which include tools to measure anxiety and depression. Participants will be asked to complete these questionnaires again at 1 month and 3 months post enrollment. conditions: Brain Injury Traumatic Mild conditions: Brain Injuries conditions: Brain Injuries, Acute conditions: Head Injury With Intracranial Hemorrhage conditions: Head Injury Trauma conditions: Brain Injury Traumatic Focal With Loss of Consciousness conditions: Skull Fractures conditions: Diffuse Axonal Injury conditions: Intracranial Hemorrhages conditions: Head Injury studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 2592 type: ESTIMATED name: Validated Questionnaires name: Questionnaires name: Clinician / Medical Record Variables measure: New or worsening depression or anxiety measure: Unmet mental health care needs in patients with new or worsening depression or anxiety measure: Decline in quality of life measure: Persistent mTBI symptoms measure: New deficits in emotional/behavioral functioning or hyperactivity/inattention measure: Parent Perception of Unmet Mental Health Needs sex: ALL minimumAge: 11 Years maximumAge: 17 Years stdAges: CHILD facility: University of California, Davis Medical Center city: Sacramento state: California zip: 95817 country: United States name: Maria Marois, PhD, MPH role: CONTACT phone: 916-734-0373 email: [email protected] name: Kyle Pimenta, BAS role: CONTACT phone: 916-734-8847 email: [email protected] name: Daniel K Nishijima, MD, MAS role: PRINCIPAL_INVESTIGATOR lat: 38.58157 lon: -121.4944 facility: Children's Hospital of Philadelphia city: Philadelphia state: Pennsylvania zip: 19104 country: United States name: Daniel Corwin, MD role: CONTACT phone: 215-327-2306 email: [email protected] name: Melissa Godfrey, MPH role: CONTACT phone: 302-598-2134 email: [email protected] name: Kristy Arbogast, PhD role: PRINCIPAL_INVESTIGATOR lat: 39.95233 lon: -75.16379 facility: Hasbro Children's Hospital and Brown University city: Providence state: Rhode Island zip: 02903 country: United States name: Mark Zonfrillo, MD role: CONTACT phone: 401-606-3532 email: [email protected] name: Mhina Johnbaptiste, MPH role: CONTACT phone: 954-591-1222 email: [email protected] name: Mark Zonfrillo, MD, MSCE role: PRINCIPAL_INVESTIGATOR lat: 41.82399 lon: -71.41283 facility: University of Texas Southwestern Medical Center city: Dallas state: Texas zip: 75390 country: United States name: Mohamed Badawy, MD role: CONTACT phone: 214-456-7106 email: [email protected] name: Aja Bayo, MSc role: CONTACT phone: 214-457-1793 email: [email protected] name: Mohamad Badawy, MD role: PRINCIPAL_INVESTIGATOR lat: 32.78306 lon: -96.80667 facility: Baylor College of Medicine, Texas Children's Hospital city: Houston state: Texas zip: 77030 country: United States name: Andrea Cruz, MD, MPH role: CONTACT phone: 832-824-5582 email: [email protected] name: Victor Gonzalez, MD role: CONTACT phone: 832-824-5977 email: [email protected] name: Andrea Cruz, MD, MPH role: PRINCIPAL_INVESTIGATOR lat: 29.76328 lon: -95.36327 facility: The Medical College of Wisconsin, Inc. city: Milwaukee state: Wisconsin zip: 53226 country: United States name: Danny G Thomas, MD, MPH role: CONTACT phone: 414-266-2625 email: [email protected] name: Najia Ali role: CONTACT phone: 414-266-2767 email: [email protected] name: Danny G Thomas, MD, MPH role: PRINCIPAL_INVESTIGATOR lat: 43.0389 lon: -87.90647 hasResults: False |
<|newrecord|> nctId: NCT06370507 id: UPO2# briefTitle: Monitoring of Lung Ventilation Through Electrical Impedance Tomography During Pediatric Surgery acronym: VentiPed overallStatus: NOT_YET_RECRUITING date: 2024-04-15 date: 2024-12-31 date: 2025-07-31 date: 2024-04-17 date: 2024-04-17 name: Azienda Ospedaliero Universitaria Maggiore della Carita class: OTHER briefSummary: Given the scarcity of studies aimed at assessing the effect of anesthesia and m ventilation on the distribution of lung ventilation in pediatric patients undergoing surgery, with the exclusion of thoracic surgery, the present prospective observational study would shed the light on ventilation practice in pediatric anesthesia for surgery. This study wold fill the actual gap allowing the evaluation, through electrical impedance tomography (EIT) of the distribution of lung ventilation across the different phases of anesthesia for pediatric surgery. These insights could contribute to improve clinical practice and research in the management of ventilation in pediatric patients undergoing anesthesia for surgery. conditions: Ventilator Lung conditions: Surgery conditions: Pediatric studyType: OBSERVATIONAL observationalModel: CASE_CROSSOVER timePerspective: PROSPECTIVE count: 800 type: ESTIMATED name: Electrical impedance tomography assessment of ventilation distribution in course of sedation/general anesthesia for pediatric surgery measure: Ventilation distribution measure: Intraoperative ventilatory respiratory mechanics measure: Postoperative pulmonary complications measure: Intraoperative oxygenation measure: Intraoperative hemodynamics sex: ALL minimumAge: 0 Days maximumAge: 14 Years stdAges: CHILD hasResults: False |
<|newrecord|> nctId: NCT06370494 id: IRB2020-0956D briefTitle: Testing New Models of Diabetes Self-Management to Improve Population Health overallStatus: COMPLETED date: 2019-02-01 date: 2022-03-31 date: 2022-03-31 date: 2024-04-17 date: 2024-04-17 name: Texas A&M University class: OTHER name: Blue Cross Blue Shield briefSummary: Aim 1.1 To understand if diabetes self-management education and support (DSMES) improves diabetes-related outcomes among those with Type 2 diabetes living in Texas. |
Aim 1.2 To examine how rurality affects study participation, engagement in, and effectiveness of different education interventions. |
These aims are based on a randomized controlled trial of different evidence-based diabetes self-management interventions. conditions: Diabetes Mellitus, Type 2 studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: SEQUENTIAL interventionModelDescription: A randomized controlled trial (RCT) was conducted to assess the outcomes associated with different technological intervention approaches. This 3-arm RCT assessed independent and combined interventions: primaryPurpose: SUPPORTIVE_CARE masking: NONE count: 191 type: ACTUAL name: Living Healthier with Diabetes measure: A1C -Change in HbA1c between baseline, 3 months, and 6 months is the primary outcome. measure: Diabetes Knowledge: Knowledge of diabetes will be measured by the simplified version of the Revised Diabetes Knowledge Scale (True/False version). measure: Diabetes Self Care measure: Diabetes Care Confidence measure: Diabetes care distress measure: A1C sex: ALL minimumAge: 25 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Texas A&M Health city: College Station state: Texas zip: 77843-1266 country: United States lat: 30.62798 lon: -96.33441 hasResults: False |
<|newrecord|> nctId: NCT06370481 id: IRB-300012349 briefTitle: HIV, Equity, and Addiction Training (HEAT) Program acronym: HEAT overallStatus: NOT_YET_RECRUITING date: 2024-06 date: 2029-06 date: 2029-12 date: 2024-04-17 date: 2024-04-26 name: University of Alabama at Birmingham class: OTHER briefSummary: This project is a pilot study to determine the feasibility and acceptability of a telemedicine intervention for substance use disorder service delivery in diverse people living with HIV in Alabama. conditions: Substance Use Disorders conditions: Hiv conditions: Opioid Use Disorder conditions: Stimulant Use (Diagnosis) studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 30 type: ESTIMATED name: Telemedicine name: Standard of care measure: Percent of participants who have a follow-up healthcare visit sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of Alabama at Birmingham city: Birmingham state: Alabama zip: 35294 country: United States name: Tyler O'Rear role: CONTACT phone: 205-721-5735 email: [email protected] name: Ellen F Eaton, MD, MSPH role: PRINCIPAL_INVESTIGATOR lat: 33.52066 lon: -86.80249 hasResults: False |
<|newrecord|> nctId: NCT06370468 id: 2024-CR-China briefTitle: The Epidemiological and Intrinsic Characteristics of Chronic Rhinitis overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2027-05-01 date: 2027-08-01 date: 2024-04-17 date: 2024-04-22 name: Zheng Liu ENT class: OTHER name: Peking Union Medical College name: Hainan People's Hospital name: Shandong Second Provincial General Hospital name: First Affiliated Hospital of Chongqing Medical University name: First Affiliated Hospital of Xinjiang Medical University briefSummary: Chronic rhinitis affects 10-40% of China's population, or over 300 million people, and can lead to respiratory and psychological issues. Despite treatment progress, 30% of patients have poor outcomes, likely due to the disease's complexity and a lack of new treatment targets. The incidence is rising, but there's a lack of nationwide studies on its variations. This study addresses this through a multicentric survey to create a national database on chronic rhinitis, including epidemiological, clinical, and biological data. The goal is to understand chronic rhinitis's causes and risks, improve treatments, and develop preventive strategies. The study will survey 30,000 patients across China, using questionnaires and nasal exams, and preserve biological samples in a biobank for detailed analysis. This will lay the groundwork for understanding the disease's mechanisms, developing new diagnostics, and tailoring prevention and treatment approaches for different forms of chronic rhinitis. conditions: Chronic Rhinitis studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: CROSS_SECTIONAL count: 150000 type: ESTIMATED name: Epidemiological investigation measure: The prevalence and distribution patterns of chronic rhinitis within the Chinese population measure: The clinical features and endotype of chronic rhinitis sex: ALL minimumAge: 18 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Tongji Hosptial affiliated to Tongji Medical college of Huazhong University of Science and Technology city: Wuhan state: Hubei zip: 430030 country: China lat: 30.58333 lon: 114.26667 hasResults: False |
<|newrecord|> nctId: NCT06370455 id: 36264MS429/11/23 briefTitle: Comparison of Septal Advancement Flap and Columellar Strut Effect on Nasal Tip overallStatus: RECRUITING date: 2024-01-23 date: 2025-02-23 date: 2025-04-20 date: 2024-04-17 date: 2024-04-22 name: Tanta University class: OTHER briefSummary: The aim of the study to compare and evaluate the effect of septal advancement flap in preserving and reshaping the nasal tip with columellar strut graft conditions: Rhinoplasty studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SCREENING masking: TRIPLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 30 type: ESTIMATED name: comparison of septal advancement flap effect on nasal tip in primary rhinoplasty to columellar strut technique measure: subjective assessment using Rhinoplasty Outcome Evaluation Questionnaire measure: measuring the degree of tip projection and rotation preoperative and postoperative sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Otorhinolaryngology department -Tanta University Hospitals status: RECRUITING city: Tanta country: Egypt name: Mohamed Elsayed Elkady, MD role: CONTACT phone: 01004582738 phoneExt: +2 lat: 30.78847 lon: 31.00192 hasResults: False |
<|newrecord|> nctId: NCT06370442 id: 2137695 briefTitle: Intranasal Dexmedetomidine vs. Standard of Care for Emergency Department (ED) Procedural Sedation in the Older Adult overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2025-05-31 date: 2025-09-01 date: 2024-04-17 date: 2024-04-22 name: State University of New York - Upstate Medical University class: OTHER briefSummary: The purpose of the study is to determine if intranasal dexmedetomidine could be an alternative to the current standard of care (injectable benzodiazepines or antipsychotics) for sedation prior to computerized tomography (CT) or magnetic resonance imaging (MRI) in those greater than or equal to 65 years of age (older adults) that are seen in the Emergency Department (ED). conditions: Altered Mental Status studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SUPPORTIVE_CARE masking: DOUBLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER count: 60 type: ESTIMATED name: Dexmedetomidine name: Lorazepam name: Haloperidol measure: Sedation sex: ALL minimumAge: 65 Years stdAges: OLDER_ADULT hasResults: False |
<|newrecord|> nctId: NCT06370429 id: 8743432956-050.99-621064 briefTitle: Effect of Online Exercises for Premenstrual Syndrome on Couple's Stress and Family Function overallStatus: NOT_YET_RECRUITING date: 2024-04-15 date: 2024-08-30 date: 2024-12-30 date: 2024-04-17 date: 2024-04-17 name: Suleyman Demirel University class: OTHER briefSummary: Universe of Research The universe of the research; It will consist of women and their spouses with premenstrual syndrome complaints who use social media. |
3.6. Sample of the Research The number of samples of the study was composed of a total of 60 (Intervention = 30, Control = 30) participants. |
Criteria for inclusion in the study: |
* Being married and living with his wife |
* Being between the ages of 18-45, |
* The woman's ability to use a mobile phone and/or computer to receive online |
* The woman and her husband must be literate |
* The woman does not have a hearing problem that would prevent her from understanding the voice recording, 9. Scoring 110 or above on the Premenstrual Syndrome Scale 10. Having regular menstrual cycles for the last six months, 13. Having no other medical disease in the last six months, 14. Participant who does not use oral contraceptives, 16. Not pregnant or breastfeeding, 17. No history of cancer. 18. Those who do not use medical drugs to reduce premenstrual syndrome 19. Those who do not use herbal medicine to reduce premenstrual syndrome 20. Do not practice exercise, yoga, etc. to reduce premenstrual syndrome. |
Exclusion criteria from the study: |
1. He or his spouse fills out the research survey forms incompletely, |
2. Pregnancy occurs, |
3. Receiving breathing exercise consultancy from another consultant during the study period |
Data Collection Method and Duration Descriptive Characteristics Data Form, Perceived Stress Scale (PSS) and Family Assessment Scale will be applied to the sampled women and their spouses. Data collection will continue until the calculated sample number is reached. conditions: Premenstrual Syndrome conditions: Exercises conditions: Stress Level conditions: Family Characteristics studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: The sample was divided into intervention and control groups primaryPurpose: SUPPORTIVE_CARE masking: NONE count: 60 type: ESTIMATED name: Progressive Relaxation Exercises, randomized pretest-posttest measure: Premenstrual Syndrome Scale measure: Family Assessment Scale measure: Perceived Stress Scale sex: ALL minimumAge: 18 Years maximumAge: 45 Years stdAges: ADULT facility: Suleyman Demirel University city: Isparta zip: 32500 country: Turkey lat: 37.76444 lon: 30.55222 hasResults: False |
<|newrecord|> nctId: NCT06370416 id: HSKY002 briefTitle: the Prevention of Bone Marrow Suppression Caused by Chemotherapy in Advanced NSCLC With Trilaciclib overallStatus: NOT_YET_RECRUITING date: 2024-04-30 date: 2025-04-30 date: 2025-12-31 date: 2024-04-17 date: 2024-04-17 name: Henan Cancer Hospital class: OTHER_GOV name: Jiangsu Simcere Pharmaceutical Co., Ltd. briefSummary: This study is a single arm, exploratory clinical study aimed at evaluating the efficacy and safety of tralazili before chemotherapy in patients with NSCLC.After pathological diagnosis of non-small cell lung cancer(NSCLC), 40 eligible subjects who met the inclusion criteria were screened and given a treatment regimen of trilaciclib before chemotherapy, after signing informed consent. conditions: Non-small Cell Lung Cancer studyType: INTERVENTIONAL phases: PHASE2 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: PREVENTION masking: NONE count: 40 type: ESTIMATED name: Trilaciclib measure: The incidence of grade ≥ 3 neutropenia during chemotherapy treatment measure: The incidence of grade 4 neutropenia during chemotherapy treatment measure: The incidence of grade 3 or grade 4 thrombocytopenia measure: The incidence of grade 3 or 4 anemia during chemotherapy treatment measure: Objective relief rate measure: Disease control rate measure: Progression free survival measure: Overall survival sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Henan Tumor Hospital city: Zhengzhou state: Henan zip: 450000 country: China lat: 34.75778 lon: 113.64861 hasResults: False |
<|newrecord|> nctId: NCT06370403 id: LithuanianSportsU-21 briefTitle: Effects of Head and Neck Cooling and Heating on Fatigue in Multiple Sclerosis and Healthy Men overallStatus: COMPLETED date: 2014-02-04 date: 2016-03-01 date: 2017-01-08 date: 2024-04-17 date: 2024-04-19 name: Lithuanian Sports University class: OTHER briefSummary: Local head and neck cooling strategies can help reduce multiple sclerosis-related fatigue, while heating can exacerbate heat-related fatigue. However, no study has detailed the peripheral and central responses to head and neck cooling (at 18°C) and heating (at 43 ± 1°C next to the scalp and neck skin) during fatiguing isometric exercise in non-challenging ambient temperature in multiple sclerosis and healthy male subjects. In addition, there is a lack of data describing the effects of head and neck cooling/heating and strenuous exercise on blood markers, muscle temperature, motor accuracy, and rate of perceived exertion. The investigators hypothesized that: (i) men with multiple sclerosis would be more affected by central and peripheral fatigue compared to healthy subjects; (ii) local cooling will result in greater central fatigue but will be associated with greater peripheral fatigue, whereas heating will result in greater central and peripheral fatigue in multiple sclerosis men; (iv) local cooling and heating will have a greater effect on the release of stress hormones, rate of perceived exertion and motor accuracy compared to the control condition in both multiple sclerosis and healthy groups. conditions: Multiple Sclerosis studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: PREVENTION masking: NONE maskingDescription: The researchers who analyzed the venous blood samples were blinded. count: 40 type: ACTUAL name: Cooling of the head and neck name: Heating of the head and neck measure: Body weight (kg) measure: Body fat (%) measure: Body free fat mass (kg) measure: Body mass index (kg/m2) measure: Change in muscle temperature (°C) measure: Change in plasma cortisol (nmol/L) concentrations measure: Change in plasma dopamine (nmol/L) concentrations measure: Change in plasma prolactin (ng/mL) concentrations measure: Change in subjective rating of perceived exertion measure: Change in muscle activity (mV) measure: Change in muscle activity (Hz) measure: Change in voluntary torque (Nm) measure: Change in involuntary torque (Nm) measure: Change in muscle contraction and relaxation (ms) measure: Change in central activation ratio (percent) measure: Change in constant error measure: Change in absolute error measure: Height (m) sex: MALE minimumAge: 18 Years maximumAge: 45 Years stdAges: ADULT facility: Lithuanian Sports University city: Kaunas zip: LT 44221 country: Lithuania lat: 54.90272 lon: 23.90961 hasResults: False |
<|newrecord|> nctId: NCT06370390 id: community - stroke dysphagia briefTitle: Community-based Group Rehabilitation Program for Stroke Patients With Dysphagia overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2024-06 date: 2024-06 date: 2024-04-17 date: 2024-04-17 name: Copka Sonpashan class: OTHER_GOV briefSummary: Community-based exercise programs have demonstrated potential for implementation in older adults; however, it remains imperative to ascertain whether this strategy will yield comparable benefit in stroke patients with dysphagia.Participants were randomly assigned to either the intervention group or the control group. Patients in the intervention group received swallowing function training in community public spaces for 5 days every week for four-week period (60 minutes per day). Patients in the control group received no intervention. Penetration-Aspiration Scale and Standardized Swallowing Assessment (SSA), depressive symptoms (Geriatric Depression Scale-15), and meal duration were assessed before and after all the treatment. conditions: Stroke studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 200 type: ESTIMATED name: swallowing function training measure: Standardized Swallowing Assessment Scale measure: Time consumed in eating measure: Penetration-Aspiration Scale measure: 15-item Geriatric Depression Scale sex: ALL minimumAge: 65 Years stdAges: OLDER_ADULT hasResults: False |
<|newrecord|> nctId: NCT06370377 id: 0305899 briefTitle: Nurses' Adherence to Professional Nursing Code of Ethics and Quality of Nursing Care Satisfaction overallStatus: COMPLETED date: 2022-12-01 date: 2023-02-28 date: 2023-02-28 date: 2024-04-17 date: 2024-04-17 name: Matrouh University class: OTHER briefSummary: Nursing code of ethics is an essential part of nursing professional practice. Nurses' adherence to a code of ethics is an important pillar of improving their performance, providing good nursing care and achieving patient satisfaction. conditions: Professional Role conditions: Nurse's Role conditions: Ethics, Narrative conditions: Satisfaction, Patient studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: CROSS_SECTIONAL count: 400 type: ACTUAL name: the Egyptian code of ethical practice measure: Questionnaire to measure source of nurses' knowledge about Egyptian code of ethics measure: Observational checklist to measure measure: Questionnaire to measure patient satisfaction with the quality of nursing care sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Faculty of Nursing, Matrouh University city: Mersa Matruh zip: 002 country: Egypt lat: 31.3529 lon: 27.23725 hasResults: False |
<|newrecord|> nctId: NCT06370364 id: 25 briefTitle: Nurses' Practice of Safe Blood Transfusion in Surgical and Critical Care Units overallStatus: COMPLETED date: 2020-12-01 date: 2021-04-30 date: 2021-04-30 date: 2024-04-17 date: 2024-04-17 name: Matrouh University class: OTHER briefSummary: Blood transfusions are an important part of nursing procedure. Nurses play a key role in safely administering blood products to patients in surgical and critical care unit conditions: Practice Nurse's Scope conditions: Blood Transfusion studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: CROSS_SECTIONAL count: 350 type: ACTUAL name: Nurses' Practice of Safe Blood Transfusion measure: Questionnaire to measure factors affecting safe blood transfusion measure: observational checklist to measure nurses' practice of safe blood transfusion sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Faculty of Nursing, Matrouh University city: Mersa Matruh zip: 002 country: Egypt lat: 31.3529 lon: 27.23725 hasResults: False |
<|newrecord|> nctId: NCT06370351 id: SENS-501-101 id: 2023-504466-28-00 type: CTIS briefTitle: A Phase I/II Clinical Trial With SENS-501 in Children Suffering From Severe to Profound Hearing Loss Due to Otoferlin (OTOF) Mutations acronym: AUDIOGENE overallStatus: NOT_YET_RECRUITING date: 2024-04-30 date: 2027-04 date: 2031-04 date: 2024-04-17 date: 2024-04-17 name: Sensorion class: INDUSTRY briefSummary: This study intends to assess safety, tolerability, and efficacy of SENS-501 in children between the ages of 6-31 months with pre-lingual hearing loss due to a mutation in the Otoferlin gene. conditions: OTOF Gene Mutation conditions: DFNB9 conditions: Congenital Deafness conditions: Hearing Disorders conditions: Ear Diseases conditions: Otorhinolaryngologic Diseases conditions: Deafness conditions: Hearing Loss, Sensorineural studyType: INTERVENTIONAL phases: PHASE1 phases: PHASE2 allocation: NON_RANDOMIZED interventionModel: SEQUENTIAL primaryPurpose: TREATMENT masking: NONE count: 12 type: ESTIMATED name: SENS-501 administration measure: Safety and tolerability of SENS-501 measure: Efficacy of SENS-501 assessed by ABR measure: Safety and tolerability of SENS-501 measure: Efficacy of SENS-501 assessed by ABR measure: Efficacy of SENS-501 assessed by PTA measure: Clinical performance of the administration system measure: Safety of the administration system measure: Usability of the administration system sex: ALL minimumAge: 6 Months maximumAge: 31 Months stdAges: CHILD facility: Hopital Necker Enfants Malades city: Paris zip: 75015 country: France name: Natalie LOUNDON, Pr role: CONTACT phone: +33(0)171396782 email: [email protected] name: Natalie LOUNDON, Pr role: PRINCIPAL_INVESTIGATOR lat: 48.85341 lon: 2.3488 hasResults: False |
<|newrecord|> nctId: NCT06370338 id: 2024B0101 briefTitle: Cardiothoracic Critical Care as Subspecialty and Its Core Competencies overallStatus: RECRUITING date: 2024-04-11 date: 2025-04-30 date: 2025-04-30 date: 2024-04-17 date: 2024-04-18 name: Ohio State University class: OTHER briefSummary: The aim of this study is to develop a consensus on the curriculum for training cardiothoracic critical care by first evaluating the need for the field, based on a Delphi consensus among a panel of experts in this field. conditions: Consensus Development studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 68 type: ESTIMATED name: Delphi Questionnaire measure: Degree of consensus on the curriculum for training cardiothoracic critical care by first evaluating the need for the field measure: Degree of consensus on defining training core competencies, goals, and milestones. measure: Degree of consensus on the definitions of "Scholarship", "Patient", "Safety", "Quality" sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: The Ohio State University Wexner Medical Center status: RECRUITING city: Columbus state: Ohio zip: 43210 country: United States name: Alberto Uribe, MD role: CONTACT phone: 614-293-3559 email: [email protected] name: Jeremy Reeves, BA role: CONTACT phone: 6148067569 email: [email protected] lat: 39.96118 lon: -82.99879 hasResults: False |
<|newrecord|> nctId: NCT06370325 id: 23-00987 briefTitle: Neuromuscular Electrical Stimulation in Foot and Ankle Surgery overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2024-08 date: 2024-08 date: 2024-04-17 date: 2024-04-17 name: NYU Langone Health class: OTHER briefSummary: This is a pilot randomized controlled trial, wherein the intervention group will undergo NMES five days a week beginning three weeks postoperative and lasting for ten weeks. Both the control and intervention groups will start standard physical therapy six weeks postoperative. Primary outcome measure will be the isometric strength of the gastrocnemius muscle. The secondary outcomes will comprise subjective clinical evaluations (using the Lower Extremity Functional Scale \[LEFS\]), functional assessments such as the sit-to-stand test, 2-minute walk test, stair climb test and objective clinical evaluation using contralateral comparison of calf circumference. conditions: Ankle Fractures studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 20 type: ESTIMATED name: VPOD Wireless Tens Unit name: Physical Therapy name: Biodex measure: Isometric Strength of Gastrocnemius Muscle measure: Isometric Strength of Gastrocnemius Muscle measure: Isometric Strength of Gastrocnemius Muscle measure: Bilateral Calf Circumference measure: Bilateral Calf Circumference measure: Bilateral Calf Circumference measure: Lower Extremity Functional Scale (LEFS) Questionnaire Score measure: Lower Extremity Functional Scale (LEFS) Questionnaire Score measure: Lower Extremity Functional Scale (LEFS) Questionnaire Score measure: Sit-to-Stand Test measure: Sit-to-Stand Test measure: Sit-to-Stand Test measure: 2 Minute Walk Test measure: 2 Minute Walk Test measure: 2 Minute Walk Test measure: Stair Climb Test measure: Stair Climb Test measure: Stair Climb Test sex: ALL minimumAge: 18 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: NYU Langone Health city: New York state: New York zip: 10016 country: United States lat: 40.71427 lon: -74.00597 hasResults: False |
<|newrecord|> nctId: NCT06370312 id: 2023-07921-01 briefTitle: Analysis of Articular Biomarkers From Osteoarthritic Thumb Basal Joints overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2026-04-30 date: 2027-04-30 date: 2024-04-17 date: 2024-04-17 name: Region Skane class: OTHER briefSummary: The study project aims at examining molecular markers in synovial fluid, bone and articular cartilage from osteoarthritic thumb basal joints. The degradation of extracellular matrix (ECM) proteins in thumb basal joints will be evaluated in association to the metabolic profile of the patient, but we also aim to compare the ECM degradation and inflammatory profiles with articular cartilage degradation ECM profile from knee joints with osteoarthritis. A third aim is to evaluate associations between patient-reported hand function, pain, strength and range of thumb motion to analyses of synovial fluid. conditions: Osteoarthritis Thumb conditions: Osteoarthritis, Knee conditions: Metabolic Disease studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 120 type: ESTIMATED name: Trapeziectomy measure: Serum cholesterol levels sex: ALL minimumAge: 25 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False |
<|newrecord|> nctId: NCT06370299 id: 2023-06402-01 briefTitle: Screening of Multidrug Resistant Bacteria, and the Clinical Implication for the Patient overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2024-12 date: 2025-06 date: 2024-04-17 date: 2024-04-17 name: Region Skane class: OTHER name: Lund University briefSummary: The goal of this observational study is to evaluate the screening for multidrug resistant bacteria in patients admitted to hospitals in Scania. The main questions it aims to answer are: |
* admission rates after screening |
* 30-day and one-year mortality after screening Participants will be evaluated for positive screening results with following multidrug resistant gram negative bacilli: ESBL producing Enterobacterales, Carbapenemase producing Enterobacterales, Carbapenem resistant P.aeruginosa and carbapenem resistant Acinetobacter baumannii. Researchers will compare patients with positive and negative screening results to see, if the relative risks in the two groups differ in admission rates and mortality. conditions: Multi-antibiotic Resistance studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 10000 type: ESTIMATED name: (exposure of) MDR carriage measure: The ratio of the probability of all-cause admission in patients who are screening positive to the probability of all-cause admission in patients who are screening negative. measure: The ratio of the probability of death in patients who are screening positive to the probability of death in patients who are screening negative. measure: The ratio of the probability of antibiotic use in patients who are screening positive to the probability of antibiotic use in patients who are screening negative. measure: prevalence of positive screening results measure: prevalence of MDR in clinical samples measure: time to first occurrence of phenotypically same MDR as in screening measure: prevalence of MDR in clinical samples in patients with negative screening results sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT hasResults: False |
<|newrecord|> nctId: NCT06370286 id: PACNL_rueihongli_CE_IC briefTitle: The Effect of Acute Concurrent Exercise on Inhibitory Control: An Event-related Potential Study overallStatus: COMPLETED date: 2021-02-15 date: 2021-08-15 date: 2022-02-15 date: 2024-04-17 date: 2024-04-18 name: National Taiwan Normal University class: OTHER briefSummary: The present study aimed to determine the effects of acute concurrent exercise on inhibitory control via behavioral and event-related potential approaches and to examine its potential mediational role on lactate among younger adults. The main questions it aims to answer are: (1) Does acute concurrent exercise improve inhibitory control via behavioral and event-related potential approaches? (2) Does lactate play a potential mediational role in the effect of acute concurrent exercise on inhibitory control? conditions: Exercise conditions: Cognition studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Participants were randomly assigned to either a concurrent exercise (CE), aerobic exercise (AE), or control (CON) group. Participants in the CE group engaged in 12-minutes of AE (40%-59% of heart rate reserve \[HRR\]) coupled with 13-minutes of resistance exercise (1 set, with 75% of 10-repetition maximum, and 12 repetitions of 8 movements). The AE group participated in 25 minutes of AE (40%-59% HRR). Prior to and following exercise onset, participants in both the CE and AE groups completed a 5-minute warm-up and cool-down. Participants in the CON group read books for 35 minutes. Lactate concentrations were measured at timepoint of 0-, 17-, and 30-minutes relative to the treatment onset. Response time (RT) and accuracy in the Stroop test, as well as P3 amplitudes, were assessed before and after the treatment. primaryPurpose: TREATMENT masking: NONE count: 78 type: ACTUAL name: concurrent exercise (CE) name: aerobic exercise (AE) measure: Inhibitory control measure: Blood lactate sex: ALL minimumAge: 20 Years maximumAge: 30 Years stdAges: ADULT facility: Department of Physical Education and Sport Sciences, National Taiwan Normal University city: Taipei zip: 106 country: Taiwan lat: 25.04776 lon: 121.53185 hasResults: False |
<|newrecord|> nctId: NCT06370273 id: 1009305 briefTitle: Thromboprophylaxis in Lower Limb Immobilisation acronym: TiLLI overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2028-02 date: 2028-02 date: 2024-04-17 date: 2024-04-17 name: Queen Mary University of London class: OTHER briefSummary: The goal of this clinical trial is to find out the clinical and cost effectiveness of Thromboprophylaxis in participants who have been placed in a plaster cast or splint after injury. |
The main questions it aims to answer are: |
* whether giving tablets to people at high risks of clots after a leg injury is as good as injections (standard care) |
* whether giving any medication after a leg injury is better than standard care (advice only) for people at low risk of clots. |
Participants will be assessed to be high risk (TiLLI High) or low risk (TiLLI Low). People who are at high risk of clots will have either tablets or injections to reduce their risk. People at low risk will receive tablets, injections or no medication. |
Drug treatments will be provided for the duration of immobilisation or up to 42 days (whichever is earlier), in accordance with current NICE guidelines. The participants will be followed up for 90 days following randomisation. conditions: Thrombosis conditions: Injury Leg studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: A pragmatic, open-label, linked pair of randomised controlled trials with common outcomes and parallel economic analysis each with internal pilot phases, conducted across 30 NHS sites primaryPurpose: PREVENTION masking: SINGLE maskingDescription: Open-label study. Trial Statistician and Health Economist to be blinded for analysis whoMasked: OUTCOMES_ASSESSOR count: 10044 type: ESTIMATED name: Rivaroxaban name: Apixaban name: Enoxaparin Injectable Solution name: Tinzaparin Injectable Solution name: Dalteparin Injectable Solution name: Fondaparinux Injectable Product measure: Composite of net clinical benefit comprising clinical VTE event, major bleeding, and cause-specific mortality measure: Symptomatic VTE event occurrence measure: Major bleeding occurrence measure: Cause-specific mortality occurrence measure: Adverse and Serious adverse events measure: Medication adherence measure: Health utility (EQ-5D-5L) measure: Patient satisfaction regarding the burdens and benefits of anticoagulation measure: Hospital readmission/reattendance measure: Health and social care resource use measure: Patient longer term outcome VTE and bleeding data sex: ALL minimumAge: 16 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT hasResults: False |
<|newrecord|> nctId: NCT06370260 id: INTM-PMCF-UNIGEL id: 571/13.02.2023 type: OTHER domain: INTERMED S.A briefTitle: Assessing the Efficacy of a Hydrogen Peroxide Gel for Oral Wound Healing and Oral Hygiene overallStatus: COMPLETED date: 2023-05-02 date: 2023-12-27 date: 2023-12-27 date: 2024-04-17 date: 2024-04-17 name: National and Kapodistrian University of Athens class: OTHER name: Ioulia And Irene Tseti Pharmaceutical Laboratories S.A. briefSummary: This study aims to assess the effectiveness and safety of a hydrogen carbamide/peroxide gel, called UNISEPT® ORAL GEL, in promoting oral wound healing, alleviating postoperative symptoms, and enhancing oral hygiene. |
Study participants will include individuals with any suspicious lesion in their gums or the roof of their mouth. They will undergo a procedure to remove a small piece of tissue for testing (biopsy) in order to confirm the diagnosis.This is a standardized diagnostic procedure that involves the use of a punch, which is a plastic handpiece with a cylindrical cutting blade. Subsequently, the wound heals naturally without the need for sutures. |
Researchers are comparing this gel with a placebo (a look-and-taste-alike substance that contains no active ingredients) to see if it is helpful with healing of wounds in the mouth and associated symptoms, improving oral hygiene. Participants randomly get the hydrogen carbamide/peroxide gel or the placebo one to use for 14 days after the biopsy. The researchers will not know which one they are providing as the gel tubes will be identical. |
Oral wound healing, postoperative symptoms (such as pain, eating and speech difficulties), oral hygiene (dental plaque and gingival inflammation) and quality of life are assessed during a 14-day period after the biopsy. Participants are required to visit the clinic three times, one for the initial biopsy, one at 7 days and one at 14 days after the biopsy. They are asked to fill in some questionnaires, while certain procedures (taking a photo the site of the biopsy) and assessments (like evaluating the dental plaque and gingival inflammation) take place. During the first week they, also, keep a diary of their symptoms, as instructed. conditions: Wound Heal conditions: Postoperative Pain conditions: Biopsy Wound conditions: Wound; Mouth conditions: Quality of Life conditions: Dental Plaque conditions: Gingival Inflammation studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: This trial is designed as a prospective, randomized, placebo-controlled, triple blinded, with two parallel groups and an equal allocation ratio in all groups. In this study, the intervention consists of delivery of a hydrogen carbamide/peroxide gel or placebo gel, made by the same manufacturer. primaryPurpose: TREATMENT masking: TRIPLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 54 type: ACTUAL name: Hydrogen Carbamide/Peroxide Gel name: Placebo Gel measure: Assessment of wound healing based on Percentage Healing Index on day 14 measure: Assessment of wound healing based on Percentage Healing Index on day 7 measure: Postoperative symptoms (pain, eating and speech difficulty) during the first week (at home) measure: Postoperative symptoms (pain, eating and speech difficulty) on day 7 measure: Postoperative symptoms (pain, eating and speech difficulty) on day 14 measure: Wound healing based on clinical signs measure: Oral Hygiene - Dental Plaque: Sextant Plaque Index measure: Oral Hygiene - Gingival Inflammation: Sextant Gingival Index measure: Oral Health Related Quality of Life measure: Adverse Events measure: Participant's comments and satisfaction regarding the provided treatment/use of the products measure: Compliance sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Department of Oral Medicine & Pathology and Hospital Dentistry, School of Dentistry city: Athens state: Attiki zip: 11527 country: Greece lat: 37.97945 lon: 23.71622 hasResults: False |
<|newrecord|> nctId: NCT06370247 id: Soh-Med-23-04-07PD. briefTitle: First-time Usage of SGLT2 Inhibitors in Type 2 Diabetic Patients Who Are Fasting During Ramadan: Safety and Efficacy overallStatus: COMPLETED date: 2023-04-25 date: 2023-06-25 date: 2023-09-25 date: 2024-04-17 date: 2024-04-17 name: Sohag University class: OTHER briefSummary: All healthy Muslim adults are required to observe the Ramadan fast, which is one of Islam's five pillars. People with Type 2 Diabetes Mellitus frequently fast throughout Ramadan (T2DM). |
Although fasting during Ramadan is said to have positive effects on diabetes patients, such as a reduction in excess body weight and an improvement in lipid profile it can be linked to a slight increased risk for metabolic complications that need immediate attention, such as hypoglycemia and hyperglycemia, dehydration, and diabetic ketoacidosis (DKA The number of diabetics worldwide was projected to reach 537 million in 2021. Studies have shown that there are a rising number of people in this category, and by 2045, there will be 738 million people worldwide who have diabetes. Almost 150 million Muslims worldwide have diabetes, and this number is progressively rising. Research estimates that 118 million of these Muslims who have diabetes fast throughout Ramadan, underscoring the need of choosing the best treatment strategy at this time. Almost two-thirds of all Muslims with T2DMfast throughout the month of Ramadan, according to studies from CREED, Epidemiology of Diabetes, and Ramadan.According to this, the most recent study showed that 86% of patients with T2DMreported a fast for at least 2 weeks. |
Patient education, which should cover information on risks, lifestyle modifications, glucose monitoring, diet, exercise, and medication, is a crucial component of managing diabetes during Ramadan.Several studies have demonstrated the effectiveness and safety of sodium glucose cotransporter 2 inhibitors (SGLT2 I) in T2DM patients who are fasting throughout Ramadan. In individuals with T2DM, SGLT2 inhibitors have shown to reduce cardiovascular events and slow the course of renal disease. |
In the literature published so far, SGLT2i has shown lower rates of hypoglycemia and hypovolemia during fasting as compared to sulphonylureas (SU). conditions: SGLT2 Inhibitors, First Time Use conditions: Type2 Diabetes conditions: Fasting in Ramadan studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 60 type: ACTUAL name: HbA1c, serum creatinine, eGFR urine analysis and serum electrolyte Na and K measure: blood glucose level monitoring measure: safety of SGLT2 inhibitors usage during ramadan sex: ALL minimumAge: 18 Years maximumAge: 60 Years stdAges: ADULT facility: Sohag Faculty of Medicine city: Sohag country: Egypt lat: 26.55695 lon: 31.69478 hasResults: False |
<|newrecord|> nctId: NCT06370234 id: 201412166MINA briefTitle: The Prediction Model of NAC Response for Breast Cancer Based on The Parametric Dynamics Features. overallStatus: COMPLETED date: 2015-04-21 date: 2019-06-30 date: 2020-03-03 date: 2024-04-17 date: 2024-04-17 name: National Taiwan University Hospital class: OTHER name: Ministry of Science and Technology, Taiwan briefSummary: The main purpose of this study is to develop a computer-aided prediction model for NAC treatment response. Based on the heterogeneity of internal parametric tumor composition commonly observed, this study will utilize the histologic characteristics and treatment response to investigate the image features as input data for predicting treatment response using Deep Learning technology. Using this technique, preoperative treatment evaluation may be facilitated by tumor heterogeneity analysis from developed dynamic radiomics, and the possibility of personal medicine can be realized not far ahead. In the first two years of this study using images from DCE-MRI, PET/CT and QDS-IR, we plan to develop the image processing algorithms, including segmenting breast and tumor region, extracting image feature which reflects angiogenic properties and permeability of tumor, which are highly correlated with NAC treatment response. During the third year of the project, the morphology and texture features from first two years can be combined for PET/MRI and prediction model can be achieved in accordance with the features extracted from dynamic features extraction using longitudinal images of PET/MRI. conditions: Breast Cancer conditions: Chemotherapy Effect conditions: Diffusion Weighted MRI conditions: PET Imaging conditions: Multiparametric Magnetic Resonance Imaging studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: DIAGNOSTIC masking: NONE count: 60 type: ACTUAL name: Whole body 18F-FDG Positron Emission Tomography measure: Model Prediction power of pathological complete response(pCR) measure: Comparison of models in prediction of pathological complete response(pCR) sex: FEMALE minimumAge: 20 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False |
<|newrecord|> nctId: NCT06370221 id: psoriatic Arthritis briefTitle: The Effect of Psoriatic Arthritis on Female Sexual Dysfunction overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2024-12-20 date: 2024-12-30 date: 2024-04-17 date: 2024-04-17 name: Egymedicalpedia class: INDUSTRY briefSummary: Psoriasis is one of the most common immunemediated chronic inflammatory skin disorders. conditions: Psoriatic Arthritis studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: PROSPECTIVE count: 180 type: ESTIMATED name: The effect of psoriatic Arthritis measure: Evaluation of female sexual function sex: FEMALE minimumAge: 20 Years maximumAge: 40 Years stdAges: ADULT facility: Qena Hospital city: Qinā country: Egypt name: Eisa Hegazy, Assist.Prof role: CONTACT phone: 01094337795 email: [email protected] lat: 26.16418 lon: 32.72671 hasResults: False |
<|newrecord|> nctId: NCT06370208 id: LUMHS/B12/Temp/13.04.2024 briefTitle: Prophylactic Effect of Probiotic Streptococcus Salivarius K12 Against Recurrent Streptococcus Pyogenes Pharyngotonsillitis Infection in Pediatrics overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2024-11-30 date: 2024-12-31 date: 2024-04-17 date: 2024-04-17 name: Liaquat University of Medical & Health Sciences class: OTHER briefSummary: Recurrent Streptococcus pyogenes pharyngotonsillitis infection in children presents a significant health concern, characterized by frequent episodes of sore throat, fever, and swollen tonsils. These recurrent infections can lead to missed school days, discomfort, and potential complications if left untreated. Current treatment typically involves antibiotics to eradicate the bacterial infection. However, drawbacks exist with this approach, including the risk of antibiotic resistance, disruption of the gut microbiota, and potential adverse effects such as gastrointestinal upset or allergic reactions. Moreover, antibiotics do not prevent future episodes and may contribute to recurrent infections by disrupting the balance of the throat microbiome. Therefore, there is a growing interest in alternative approaches such as probiotics, which aim to support the body's natural defenses and restore microbial balance in the throat and oral cavity. conditions: Streptococcus Pyogenes Pharyngotonsillitis studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 60 type: ESTIMATED name: Probiotic Bactoblis® (Streptococcus salivarius K12) measure: Recurrence of Streptococcus pyogenes pharyngotonsillitis infection measure: Probiotic safety and tolerability measure: Protection against viral infection measure: Protection against Acute Otitis Media infection measure: Protection against respiratory infection measure: Protection against Rhinitis measure: Protection against flu measure: Protection against Enteritis measure: Protection against Stomatitis sex: ALL minimumAge: 3 Years maximumAge: 10 Years stdAges: CHILD facility: Liaquat University of Medical and Health Sciences city: Jamshoro zip: 76090 country: Pakistan name: Dr. Ikram Ujjan, MBBS, PhD role: CONTACT phone: 03000506955 email: [email protected] lat: 25.43773 lon: 68.28522 hasResults: False |
<|newrecord|> nctId: NCT06370195 id: SGB-Liuxian briefTitle: Effect of Stellate Ganglion Block on Drooling in Parkinson's Syndrome overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2024-12 date: 2024-12 date: 2024-04-17 date: 2024-04-17 name: Babujinaya Cela class: OTHER_GOV briefSummary: This is a randomized controlled study, including dysphagic patients with Parkinson's syndrome who were received in the department of rehabilitation medicine. All patients are randomly allocated to the observation group or the control group. Both groups are provided with comprehensive rehabilitation. Besides, the observation group additionally undergoes the stellate ganglion block. At admission and after 10-day treatment, Functional Oral Intake Scale, Drooling amount, depression are assessed. conditions: Parkinson's Syndrome studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 100 type: ESTIMATED name: Comprehensive rehabilitation name: Stellate ganglion block name: Lidocaine hydrochloride name: Placebo injection measure: Drooling amount measure: Modified Barthel Index measure: Patient Health Questionnaire-9 sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False |
<|newrecord|> nctId: NCT06370182 id: ANA2401 briefTitle: Safety and Effectiveness of Mechanical Thrombectomy Using the Anaconda ANA5 Device acronym: ATHENA overallStatus: NOT_YET_RECRUITING date: 2024-09 date: 2025-12 date: 2026-03 date: 2024-04-17 date: 2024-04-17 name: Anaconda Biomed S.L. class: INDUSTRY briefSummary: The objective of this study is to assess the safety and effectiveness of mechanical thrombectomy using the ANA funnel catheter to treat people with acute ischemic stroke within 24 hours of symptom onset. The device facilitates the placement of other devices such as stent retrievers and intravascular catheters during the procedure. conditions: Acute Ischemic Stroke From Large Vessel Occlusion studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 250 type: ESTIMATED name: ANA Funnel Catheter name: Control measure: Proportion of subjects with "near-complete" reperfusion after one thrombectomy pass (FPE, eTICI 2c-3, extended Thrombolysis in Cerebral Infarction scale) in the target vessel after one reperfusion attempt. measure: Rate of symptomatic intracranial hemorrhage (sICH), attributable to the device or procedure. sex: ALL minimumAge: 22 Years maximumAge: 85 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False |
<|newrecord|> nctId: NCT06370169 id: ROSC 1 briefTitle: EUS Guided Coil Embolization for Primary Prophylaxis of Gastric Varices acronym: EUS overallStatus: RECRUITING date: 2022-08-01 date: 2024-03-30 date: 2024-08-10 date: 2024-04-17 date: 2024-04-17 name: Asian Institute of Gastroenterology, India class: OTHER briefSummary: The standard treatment of bleeding gastric varices is obliteration with placement of coil and glue. Our study will evaluate the efficacy of EUS guided coil as primary prophylaxis for high-risk gastric varices. All procedures will be performed with patient under deep sedation or general anaesthesia under the supervision of an anaesthesiologist. conditions: Gastric Varices Bleeding studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: PREVENTION masking: NONE count: 50 type: ESTIMATED name: Endoscopic ultrasound placement of Coil and glue measure: The outcome will measure number of patient had achieved complete obliteration of varices measure: Number of patient needed re intervention measure: Number of patient needed had bleeding following intervention like immediate (with in 5 days) or later (5-90 days) sex: ALL minimumAge: 18 Months maximumAge: 80 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Asian institute of Gastroenterology status: RECRUITING city: Hyderabad state: Telangana zip: 500082 country: India name: Jahangeer Dr Basha, MD DM role: CONTACT phone: 04023378888 email: [email protected] name: Sandeep Dr Nath, MD role: CONTACT phone: 04023378888 email: [email protected] lat: 17.38405 lon: 78.45636 hasResults: False |
<|newrecord|> nctId: NCT06370156 id: TWEAK in plaque psoriasis briefTitle: Evaluation of TWEAK in Plaque Psoriasis and Psoriatic Arthritis Patients overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2025-06-01 date: 2025-06-10 date: 2024-04-17 date: 2024-04-17 name: Egymedicalpedia class: INDUSTRY briefSummary: Psoriasis vulgaris is associated with significant comorbidity including depression, increased risk of cardiovascular events, diminished quality of life, as well as overall increased mortality. |
Moreover, concomitant psoriatic arthritis is present in up to 40% of psoriasis patients or will develop in the future. |
To enhance quality of life and potentially lower the risk of concomitant disease in psoriasis patients, effective treatment of this immune-mediated systemic inflammatory disease is required conditions: Plaque Psoriasis studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: PROSPECTIVE count: 100 type: ESTIMATED name: Adalimumab measure: Treatment of psoriasis vulgaris and psoriatic arthritis measure: Evaluation of serum TWEAK sex: ALL minimumAge: 20 Years maximumAge: 60 Years stdAges: ADULT facility: South Valley Hospitals city: Qinā country: Egypt name: Eisa Mohamed Hegazy, Professor role: CONTACT phone: +201094337795 email: [email protected] lat: 26.16418 lon: 32.72671 hasResults: False |
<|newrecord|> nctId: NCT06370143 id: 24-083 briefTitle: A Study Collecting Health Information to Understand and Prevent Gastric Cancer overallStatus: RECRUITING date: 2024-04-11 date: 2036-04-11 date: 2036-04-11 date: 2024-04-17 date: 2024-04-17 name: Memorial Sloan Kettering Cancer Center class: OTHER briefSummary: The purpose of this study is to create a registry of participants with precursor lesions for gastric cancer, including gastric atrophy, intestinal metaplasia, and dysplasia. Normal controls and individuals with gastric cancer for comparison of baseline characteristics will also be enrolled. conditions: Gastric Atrophy conditions: Gastric Intestinal Metaplasia conditions: Dysplasia conditions: Gastric Adenocarcinoma conditions: Gastric Cancer studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 3200 type: ESTIMATED name: Questionnaire measure: Creation of participant registry sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Memorial Sloan Kettering at Basking Ridge (Limited Protocol Activities) status: RECRUITING city: Basking Ridge state: New Jersey zip: 07920 country: United States name: Monika Laszkowska, MD role: CONTACT phone: 212-639-6857 lat: 40.70621 lon: -74.54932 facility: Memorial Sloan Kettering Monmouth (All Protocol Activities) status: RECRUITING city: Middletown state: New Jersey zip: 07748 country: United States name: Monika Laszkowska, MD role: CONTACT phone: 212-639-6857 lat: 40.39652 lon: -74.09211 facility: Memorial Sloan Kettering Bergen (Limited Protocol Activities) status: RECRUITING city: Montvale state: New Jersey zip: 07645 country: United States name: Monika Laszkowska, MD role: CONTACT phone: 212-639-6857 lat: 41.04676 lon: -74.02292 facility: Memorial Sloan Kettering Suffolk-Commack (Limited protocol activity) status: RECRUITING city: Commack state: New York zip: 11725 country: United States name: Monika Laszkowska, PhD role: CONTACT phone: 212-639-6857 lat: 40.84288 lon: -73.29289 facility: Memorial Sloan Kettering Westchester (Limited Protocol Activities) status: RECRUITING city: Harrison state: New York zip: 10604 country: United States name: Monika Laszkowska, MD role: CONTACT phone: 212-639-6857 lat: 40.96899 lon: -73.71263 facility: Memorial Sloan Kettering Cancer Center (All protocol activites) status: RECRUITING city: New York state: New York zip: 10065 country: United States name: Monika Laszkowska, MD role: CONTACT phone: 212-639-6857 lat: 40.71427 lon: -74.00597 facility: Memorial Sloan Kettering Nassau (Limited Protocol Activites) status: RECRUITING city: Rockville Centre state: New York zip: 11553 country: United States name: Monika Laszkowska, MD role: CONTACT phone: 212-639-6857 lat: 40.65871 lon: -73.64124 hasResults: False |
<|newrecord|> nctId: NCT06370130 id: AerospaceCH briefTitle: Different Dose of Esketamine Inhibiting Response to Laryngeal Mask Airway Insertion overallStatus: COMPLETED date: 2022-05-01 date: 2022-12-20 date: 2023-03-10 date: 2024-04-17 date: 2024-04-17 name: Aerospace Center Hospital class: OTHER briefSummary: Objective To prospectively determine the median effective dose (ED50) of propofol for inhibiting a response to laryngeal mask airway (LMA) insertion when combined with different doses of esketamine in female patients. |
Methods Fifty-eight female patients (aged 20-60, ASAⅠ-Ⅱ) scheduled for elective hysteroscopy were enrolled and randomly divided into two groups, one administered 0.2 mg/kg of esketamine (K1 group, n = 28) and the other 0.3 mg/kg of esketamine (K2 group, n = 30). The two groups received the corresponding doses of esketamine intravenously, followed by an intravenous injection of propofol (injection time was 30 s). The initial dose of propofol was 2 mg/kg, and the dose ratio of propofol in the adjacent patients was 0.9. If there was a positive reaction to LMA insertion, the dose ratio in the next patient was increased by one gradient, and if not, the dose ratio was decreased by one gradient. The median effective dose (ED50), 95% effective dose (ED95) and 95% confidence interval (95%CI) of propofol for inhibiting a response to LMA insertion in the two esketamine groups were calculated using a probit analysis. conditions: Anesthesia studyType: INTERVENTIONAL phases: EARLY_PHASE1 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER count: 58 type: ACTUAL name: Esketamine 0.2mg/kg name: Esketamine 0.3mg/kg measure: Record of the patient response during LMA placement measure: Overall condition of LMA placement measure: Record related indicators measure: Record related indicators measure: Record related indicators measure: Record related indicators measure: Record of additional doses of propofol and the adverse reactions of positive patients during the induction process (hypotension, bradycardia and apnoea, etc.) sex: FEMALE minimumAge: 20 Years maximumAge: 60 Years stdAges: ADULT facility: Liang-Yuan Lu city: Beijing state: Beijing zip: 100049 country: China lat: 39.9075 lon: 116.39723 hasResults: False |
<|newrecord|> nctId: NCT06370117 id: Aydın Adnan Menderes briefTitle: The Effects of Three Different Nonpharmacological Methods Used During Vascular Access in Children on Pain and Anxiety overallStatus: COMPLETED date: 2023-02-01 date: 2023-10-30 date: 2023-12-30 date: 2024-04-17 date: 2024-04-17 name: Aydin Adnan Menderes University class: OTHER briefSummary: The research was conducted to evaluate the effects of three different non-pharmacological methods (playing a music video, buzzy application, listening to a music video + buzzy application) on the pain and anxiety levels of children in the 4-12 age group during vascular access. |
H0.1. Playing music (music video) during the vascular access procedure has no effect on children's pain and anxiety levels. |
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