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A pulse pounding, take no prisoners descent into neo southern gothic horror.
When traveling through Resurrection County, watch your step and mind the signs. One false move could be your last. When two suburban couples roll into the backwoods southern town of Enoch for a weekend of all-terrain riding, their camping trip turns deadly at the hands of bloodthirsty locals who don't take kindly to outsiders. | 2019-04-21T20:52:56 | http://www.mongrelmedia.com/index.php/filmlink?id=95b187c3-3cb6-4010-90f2-cde9d758fa99 |
Separating closely related organic molecules is a challenge (see the Perspective by Lin).The separation of acetylene from ethylene is needed in high-purity polymer production. Cui et al. developed a copper-based metal-organic framework with hexafluorosilicate and organic linkers designed to have a high affinity for acetylene.
Transformation of Copper: A Sequence of Chemical Reactions. Objectives Reactions; Procedure. Objectives. Illustrate variety of substances of which an element can be part: ... Dry the copper over a beaker of boiling water as described in the procedure (E). Weigh the dry copper and record the mass. Compute the percent of copper recovered.
selon ce procédé, le moût est cuit dans une chaudière à moût, ... The invention relates to a flow guiding device in a wort copper used for deviating a heated wort flow which is moving upward in a wort copper and positioned above the wort flow outlet.
From the range to the streets, Speer LE products deliver the performance you demand. And it's no surprise Speer's own Gold Dot® is the nation's number one choice for law enforcement ammunition.
Separation of CO 2 from post-combustion flue gases is important for environmental and economic sustainability. Our copper-based hydrogel with dicarboxylate spacer ligands offers the possibility of a new material for post-combustion CO 2 capture.
Alibaba.com offers 21,112 copper separator products. About 29% of these are other metal & metallurgy machinery, 25% are mineral separator, and 1% are separation equipment. A wide variety of copper separator options are available to you, such as free samples, paid samples. There are 21,153 copper separator suppliers, mainly located in Asia.
Jul 08, 2015· Copper Extraction Equipment, Wholesale Various High Quality Copper Extraction Equipment Products from Global Copper Extraction Equipment Suppliers and Copper Extraction Equipment Factory,Importer,Exporter at apparatus use in separation techniques. Hot Sale Home Used Copper Alcohol Moonshine Still,Distillation .
6A Cable We are continually investing in improving our cable products to make sure that they have a simple design with maximum performance. Some options that are available include small diameter, non-bonded, and patented Bonded-Pair.
Interestingly for copper the gap separating the required amount and the toxic amount is quite small. It may be the smallest for all the required trace metals. This is probably why it is commonly used as a pesticide, fungicide and algaecide, because such small amounts can get the jobs done.
This layer naming convention allows the user to easily turn off and on the axonometric layers, or to separate copper from other materials.
In this experiment we demonstrate Le Chatelier's principle in case of copper(II) chloride solution. Le Chatelier's principle in general states that if a chemical dynamic equilibrium is disturbed by changing the conditions (concentration, temperature, volume or pressure), the position of equilibrium moves to counteract the imposed change.
The ameliorating effects of copper(+2) and sulfate(2-) ions on concurrent selenite toxicity were compared in two factorial experiments in weanling rats. 0, 500 and 1,000 mg copper (as cupric chloride)/kg diet were fed in conjuction with 0, 5, 10 and 20 mg selenium (as Na2Se)3)/kg diet.
Feb 16, 2012· Copper Separation table linked into our Granulator for a full copper cable separation plant. Capable of 250-350kg / hour Under 12mths old & in as new condition!
To get copper from copper sulphate solution all you have to do is to immerse metals like iron, zinc, Aluminium in the solution. The above mentioned metals will displace the Cu++ ions in the solution. Thus you get a ppt of copper metal at the bottom of the vessel.
Copper Lab. STUDY. PLAY. What type of reaction will be investigated in the copper lab? A copper reaction. An oxidation-reduction reaction. A neutralization reaction. A combustion reaction. ... Separation of a Mixture lab. THIS SET IS OFTEN IN FOLDERS WITH... 30 terms. Chem 1 Lab measurements. | 2019-04-21T16:30:33 | https://www.canvasdetail.nl/2018-11-19-35103-copper-separation-le.html |
See you tomorrow for a new month and a new start!
I would love to join you. Tell me more! | 2019-04-21T20:19:36 | http://www.chefleann.com/2013/08/photo-challenges-for-september.html?showComment=1378066622444 |
Folks, if you know Greg you know it was only a matter of time until he took the Chick Cam and made a time-lapse movie of all the images we’ve collected from the web cam.
This entry was posted in Funny Stuff on March 18, 2011 by mbonebrake.
Vinnie–Thumbs Up or Thumbs Down?
I don’t suppose it matters. Vinnie doesn’t have thumbs.
We can’t decide if he loves it when Laurel plays violin or if he hates it.
This entry was posted in Funny Stuff on March 4, 2011 by mbonebrake.
Fun with a Car Dealer; or, How I Spent My Wednesday Afternoon.
A couple of weeks ago Greg and I went truck shopping. After having trouble getting a certain dealer to call us back (though we basically walked in and said, “Hi, we want to buy a truck as soon as possible. Will you sell it to us?”), I sent an e-mail blast to every Dodge dealer in a 45-mile radius, describing exactly what we wanted, and asking for a quote.
We got about ten responses, and ended up working out a deal with a dealership that gave us the best deal. No big surprise, right?
We just wanted to make sure your on-line vehicle request is being handled to your satisfaction. I would consider it a personal favor if you would reply to this email and let me know if there is anything we can do to provide you with better service.
Did we provide the information you needed?
What would you like us to do to make your experience better?
I certainly appreciate your help. We ordered a Ram through South County Dodge on Saturday. Sorry.
Thanks for letting me know. I am however disappointed to hear that you pulled the trigger and didn’t let me see if I could beat their deal.
Do you ever have one of those days when you’re a little cranky because you’ve been corralling children and fighting to get the young one to clean his room and trying to teach the older one how to bake cookies, and something like this just RUBS YOU THE WRONG WAY?
I understand you’re disappointed. Once when I was a kid I thought I would see if my tongue would really stick to metal when it was freezing, just like Flick in “A Christmas Story.” I chose to do it myself – did it without issue of the triple-dog-dare, in fact. I was very disappointed to find the stories were true. As it turns out, the movie’s creators failed to issue a warning that children shouldn’t try those stunts at home.
Anyway, back on point, we had so many responses from dealers we simply could not make a decision. My husband and I, after 7 or 8 tequila shots, realized we had but one option. We posted each e-mail quote from dealers on the wall and commenced a dart-throwing to decide who would get our business. As it turns out, neither my husband nor I can hold our tequila, so our aim was off. I am sure if we had been sober, you would have been the winner. As it stands, we are now replacing 3 sheets of drywall and a cat.
Should be interesting to see his response.
If I don’t get back here before the holiday, Merry Christmas or Happy Festivus or whatever you celebrate or don’t celebrate or whatever.
This entry was posted in Funny Stuff on December 22, 2010 by mbonebrake.
…actually weighs 500 pounds. Just looked it up. Kinda wish I’d looked it up before we tried to get it out of the bed of the truck.
Also, see the ratcheting strap holding the machine stationary? That has become necessary because Ethan WILL NOT STAY OFF THE THING.
This entry was posted in Funny Stuff on December 7, 2010 by mbonebrake.
Early Preparation for the Teen Years.
This entry was posted in Funny Stuff on September 30, 2010 by mbonebrake.
This entry was posted in Funny Stuff on September 13, 2010 by mbonebrake.
A Common Scene from My Everyday Life.
This entry was posted in Funny Stuff on September 12, 2010 by mbonebrake. | 2019-04-23T14:19:43 | http://aguerrillalife.com/category/funny-stuff/page/2/ |
CubeSmart Self Storage of Hackettstown, NJ is revolutionizing the way you use storage in Hackettstown! Now you can expect more services, have easier access, get increased value and expect friendlier people when you store with us in Hackettstown. Just because we've been around for a while doesn't mean we can't change the game. Same Space, Same price. More services and More discounts.
Cube Smart Self Storage of Hackettstown is an excellent storage facility! The prices are affordable, the premises are clean, secure and the managers, Bob and Bill are very friendly and a pleasure to work with! I highly recommend it for your storage needs!
Nice secure location & Manager Bill & Bob were great!
Great place, lots of security, very, very clean and great customer service!
Spotless facility with excellent customer service!
'fits my needs. Able to use the facility without any problems. Unit was clean and easily accessed. | 2019-04-22T05:14:52 | https://usselfstorage.com/nj/self-storage-hackettstown/storage-bin-137412 |
Viking delivers performance and design where every single product works together in form and function with the same level of excellence. The Viking Professional 24-inch left hinge wine cellar features a forced air cooling system with a 700 BTU compressor for even temperature from top to bottom. The electronic controls maintain temperatures between 44 and 68 inch degrees. Five wood front shelves pull out for easy access and can hold up to 45 wine bottles. Each shelf is coated to reduce vibration and hold bottles snugly in place. The low-intensity interior LED lighting displays your collection with minimal heat and light output. The self-closing, dual pane glass door is argon filled for energy efficiency. The super quiet 39 dB Tru-Flush wine compact refrigerator can be used freestanding or installed flush in 24-inch deep cutouts for a seamless look.
Viking warrants this wine refrigerator for two full years, ninety days on cosmetic parts, and twelve years limited on the sealed refrigeration system. Outdoor use is not covered under the warranty.
24" 35 5/8" 24" 23 3/4"
34 1/2" 33 7/8" 34" 33 7/8" | 2019-04-24T02:50:17 | http://www.bbq.com/viking/stainless-steel-24-inch-45-bottle-left-hinge-built-in/freestanding-wine-cellar |
10. Are options priced at fair market value determined by an independent appraisal? What is the exercise price relative to the price of the preferred stock issued in your last round? Venture capital-backed startups issue options to employees at an exercise price that’s a fraction of what the investors pay.
Stock Options The housing to purchase stock at a given price at some time in appraisal future. Stock Options come in two types: Incentive stock options ISOs in which the employee appraisal able to defer taxation until the shares bought with the option are sold.
A trademark is a word, phrase, symbol, or design that is used in conjunction with, and stock identify options source of, goods or services options the marketplace e.
That said, given the cost associated with obtaining an options appraisal and its subsequent bring-downslater-stage venture-backed companies often grant stock options less frequently and appraisal batch appraisal for board housing in bulkin order to minimize the need for potentially costly stock time consuming bring-down updates.
STOCK OPTIONS | Appraisal Economics. A valuation method is "reasonably applied" if it takes into account all available information material to the value options the corporation ikili opsiyon demo hesap is applied consistently. Stock valuation method is a "reasonable valuation method" if it considers factors including, as applicable:.
Stock is an update of an article we wrote ina year after the final Section A regulations were issued by the IRS. To appreciate the significance of Appraisal A, it options important to understand the tax treatment of options stock options both before and after the adoption options Section A.
This is an update stock an article we wrote ina year after the final Section A regulations were issued by the IRS. To appraisal the significance of Section A, it is important to stock the tax treatment of nonqualified stock options both before and after the adoption of Section A.
As the name implies, non-qualified stock options represent an offer by the employer to the employee to buy company stock at a price somewhere below the current market price (assuming that the price either rises or at least stays the same, which, of course, it doesn’t always).
Introduction. Stock Options The "right" options purchase stock at a given price at some time in the future. Stock Options come in stock types: Incentive stock options ISOs in options the employee is able to defer taxation until the shares appraisal with the option are sold.
A appraisal is housing word, phrase, symbol, or design that is used in conjunction with, and to stock the options of, goods or services in the marketplace e. STOCK OPTIONS. A service mark is a form of trademark that appraisal to services instead of physical products.
Appraisal of your Closely Held Stock. There are diverse applications for a Closely Held Stock Valuation. Common reasons for the valuation, or appraisal, is for an Estate, Stock Option, and an ESOP Valuation. Often compensation may be given to an employee in the form of stock or stock options.
© Stock options appraisal Binary Option | Stock options appraisal Best binary options. | 2019-04-19T16:54:26 | http://chanelfashion.tk/stock-options-appraisal-606988.html |
ORLAITH INC, designing Solutions for Business & Marketing is a strategic marketing company providing marketing services to help transition businesses to successfully compete. We help you grow and bridge the gap between you and your customers.
We support businesses in their traditional marketing and social media marketing efforts. We provide you with strategies to help you reach your end goal.
Being on time helps us establish a good reputation and allows others to trust us. Punctuality creates professional image appears polished and organized for us.
Magic in business is about having belief in what you're doing and being boss enough to see it through.
There's no hard and fast definition of minimalism, but there is one common principle that's shared wherever it's defined; focus on the essential and eliminate the non-essential.
It is our duty to follow a morally correct path as it is our responsibilities to the many people who count on us to do the right thing.
We offer a well-regulated, transparent and supportive environment for you. Treating everyone with respect and positive attitudes will help us to work together for a larger good. | 2019-04-21T02:47:29 | http://orlaithinc.com/ |
In Care, Into Reading: How can we improve the lives of young people in care?
Published last month, In Care, Out of Trouble reports a worrying correlation between children in care and in custody, begging the question, how can we improve the lives of young people in care?
Author Emma WalshPosted on 15th June 2016 16th February 2017 Categories Schools & Young People, Shared Reading, VolunteeringTags David Cameron, In Care Out of Trouble Report, Lord Laming, Prison Reform Trust, The Guardian1 Comment on In Care, Into Reading: How can we improve the lives of young people in care? | 2019-04-24T10:38:52 | https://blog.thereader.org.uk/tag/in-care-out-of-trouble-report/ |
For all those who remain ever keen to visit an astrologer, say even for the smallest of things… you must know that no matter what the astrologer tells you, no matter what remedy or mantra the astrologer gives to you… your destiny will play out! For destiny is fixed! And if your astrologer hasn’t told you that, you probably are being kept in the dark.
Yes, undoubtedly, destiny can be predicted through a horoscope and predicted accurately at times… but what the planets hold for you (cause & effect) – must play out, irrespective of what you anticipate or fear!
On the other hand, future can be tackled! It can be created the way you wish! It can be molded and channeled in the direction you wish to take it. Because the future is unpredictable! It’s always generated from the present and therefore, you are shaping it, each moment of your life!
To understand this, let’s just first understand the difference between destiny and the future.
Astrologically, destiny is your horoscope, the planetary placements of your birth chart! The future is also somewhat reflected in the horoscope but while destiny, is what that must unfold in a certain fixed way; the future can vary!
This because, destiny is your – Prarabdha Karmas – the effect of which you have come to receive in this lifetime. They are your ripe or fructuous actions from a your Karma tree (Sanchita Karma) that have matured to bear fruits. Now, whether the fruit is bitter, sweet or sour…depends on the quality of your past, which you’ve brought into your present… as your destiny or Prarabdha!
So, depending on what you’ve done in the past, how you’ve been… is how destiny plays out. It hasn’t got much to do with the present; it’s always connected to a past! That’s why, there are people in this world who seem good and kind but their suffering is enormous, on the contrary the most wicked people, can be having a good time! Understandably, it’s the cause and effect of a certain past that has now become the ripe fruits (Prarabdha) … on the tree of collective Karma (Sanchita)!
Positions of the planets in the horoscope, (also known as the blue print of your past life deeds or your karma-scope), reflect your destiny! In whatever way the planets are positioned, their strength or weakness… all depends on the quality of your – Prarabdha Karmas! But the key thing to understand here is that destiny is fixed because your Prarabhda is fixed!
Like you cannot go back into your past and change the quality of the actions (Karma) that were done in the past; similarly, you cannot time travel and revisit your previous lifetimes to undo the bad and strengthen the good! What’s done is over! It’s something that will bear its consequence and will reward or punish… depending on what you did!
But there is no getting away from receiving the results of past actions and no getting away from receiving the rewards or punishments connected to past actions! What you owe… you must pay back, what you deserve… must come!
The past therefore, becomes your present and since this past cannot be altered in any way, neither can the present! It’s important to note that by present… one means experiences and situations, which come as a consequence of past actions. And these experiences and situations are your destiny! Therefore, destiny is fixed; it’s unalterable, inevitable! And no amount of remedies, rings, rituals or mantras…not even God can change the course of destiny, for the simple reason that destiny comes through what’s already been done! Therefore, how can anyone or anything change it?
As destiny belongs to past actions, future belongs to the present ones! Each moment while living your Prarabhdha or destiny… you create more Karmas. For we all know that Karma (Intent, thoughts, words and actions) is the natural way of life for any living being. We cannot survive without performing Karma!
Therefore, while facing our Prarabhda… we create another kind of karmas, known as the Kriyamana or Agami Karmas (current works)! So the bank account of Karmas (Sanchita Karmas) or the Karma tree is ever laden. For the simple reason that something or the other, always keeps getting added.
But how we face this Prarabhda, what is our state of mind, our thoughts, feelings and actions while facing the consequence of past actions or facing the effects of our present destiny, is what that determines the future! That’s why; future or the next life is always taking shape through our present set of Karmas!
For as long as we don’t fully settle the stock of our entire Sanchita Karmas through various Prarabhdas; as long as our Kriyamana or Agami Karmas don’t stop creating cause and effect for the future, as long as the quality of our Kriyamana or Agami Karmas doesn’t become neutral (neither good or bad)… mukti or moksha or liberation from this cycle of birth and death cannot be delivered!
And because most of us live in ignorance, reincarnation remains inevitable!
But then, should you seek to open your mind or expand consciousness, understand this key difference between destiny and future!
Destiny is what you’re living! Future is what you’re constantly building! If you choose to settle your destiny or receive your destiny… no matter how good or bad with a mind that remains unaffected, then you may just be building a future for liberation!
However, if you choose to respond to your destiny in a certain way, again, can be good or bad, through happiness or sorrow… then you are creating karmas that will fructify in the future as your prarabhdha! The important thing however is… how you choose to respond! Because no matter how tough your destiny today, if you choose to operate out of wisdom, remain positive and calm; and send out just the right energy to your future, it will manifest! The future is therefore in your hands; it’s in the choices you make today, the thoughts, words and actions that you attach to your Karmic trail and the tendencies or sanskars, you choose to live by!
So, at every step of your present life, you are living your destiny…but at the same time, how you’re living… is deciding the future! The future therefore, is always in the making! Destiny is fixed!
A good astrologer therefore, will never waste time trying to alter what the planets must deliver as your destiny! Rather, he or she will guide you… into making the right future by telling you, how to accept and live out your destiny! After all, it’s the only thing that matters! | 2019-04-24T22:12:24 | http://www.astrokarmakeys.com/destiny-may-be-fixed-the-future-isnt/ |
Madison House Autism Foundation (MHAF) & Madison Fields are thrilled about our ongoing partnership with American Airlines. Together, we can help adults living with autism reach new heights. The staff at Madison Fields gave thanks to the airline for their hours of service and valuable donations with a special salutation carved into a corner of a corn field. This fall, planes flying into the Washington, D.C. area will see the American Airlines logo appear in the corn fields at Madison Fields.
We look forward to our continued partnership with our friends at American Airlines and all of our supporters. You help us add value and bring attention to the talents and abilities of adults living with autism. Watch the video below to see our special message to American Airlines. If you or your business would like to become a MHAF/Madison Fields sponsor, please contact Adrienne at [email protected]. If you would like to make a donation to support our efforts, click here. | 2019-04-23T17:59:25 | http://madisonfields.org/2016/09/american-airlines-corporate-sponsorship-taking-mhaf-to-new-heights/ |
On July 2, as a part of the Penn State Department of Architectural Engineering Centennial Celebration, I presented a seminar titled Learning From Building Failures to an audience of practitioners and AE students. The continuing education seminar focused on studying building failures to assist in the investigation of failures as a part of forensic practice or to become a better structural engineering designer by avoiding the mistakes of others.
Identifying Trends: Another theme of the seminar was that of identifying trends in failures as they realte to specific building types or assemblies. Specific examples discussed included identification of trends related to metal-plate wood trusses (ie lack of temporary or permanent bracing) and engineered metal buildings (problems related to purlin design and bracing). Forensic analysis and review involves keeping an open mind during the investigation but trend information can be used to help identify the problem at hand or as a means of elimination of possible causes.
Historical Case Studies: Case studies from historical failures are often an excellent source of information for engineers and forensic investigators. A good place to start the learning process is going direct to the Failures Wiki, or using the link on this site. Failuire examples available for review range form roof collapses, or full building collapses to facade defects and waterproofing issues.
More Information: Additional infromation on the Learning from Failures Seminar or failures education at Penn State is available by providing a comment to this post.
i want know what full information did u give on the learning from buildings failures.
The session was fairly short so it basically was an overview on building failures. Our discussion included general causes of structural and architectural failures. One of the features was a quick look at a number of historical failure case studies to see what lessons had (and had not ) been learned. From this we noted the role of human or procedural errors in so many failures. We also looked at a couple of examples of failure trends so that investigators and educators can identify common problems that occur. For this part of the program, I discussed some of the common problems with metal plated wood trusses and engineered metal buildings.
A full day seminar is being planned as a continuing and distance education class as part of a new initiative at Penn State. Dates will be announced later in the spring. | 2019-04-22T16:11:44 | https://buildingfailures.com/2010/07/08/learning-from-failures/ |
In the 2nd and 3rd weeks of February, all of Berlin will be a-buzz with boozing, schmoozing film-makers. Meanwhile Zazuka and Junodori will make an escape from their respective roles as filmkomponistin and filmmischmeisterin (don’t you just love German compound nouns?!) to tickle the ivories of this town! They will be promoting for their concert on 23rd Feb. at a gorgeous Greek tavern with a baby grand. Details below!
Zazuka and Junodori Double Concert.
Playing with Zazuka will be Matthias Haffner (Percussions) and Mari Häring (Viola). | 2019-04-26T10:11:48 | http://zazuka.com/zazuka-junodori-berlinale-concert/ |
"Change is Here!" a celebration of the inauguration of Barack Obama , will be held Tuesday from 7:30 to 10 p.m. by the Ridgefield Democratic Town Committee at the Ridgefield Community Center , 316 Main St.
The evening includes cocktails, canapes, dancing and music. Tickets are $80 at the Joyous and Hopeful level, $100 at the Thrilled and Confident level, and $250 at the Over-the-Moon and Back on Track level.
Contact Betsy Thompson at (203) 894-9199 for reservations. | 2019-04-25T16:01:02 | https://www.newstimes.com/news/article/Ridgefield-Democrats-throw-inaugural-bash-102595.php |
This is a placeholder page for Robert Schaffer, which means this person is not currently on this site. We do suggest using the tools below to find Robert Schaffer.
You are visiting the placeholder page for Robert Schaffer. This page is here because someone used our placeholder utility to look for Robert Schaffer. We created this page automatically in hopes Robert Schaffer would find it. If you are not Robert Schaffer, but are an alumni of New Albany High School, register on this site for free now. | 2019-04-26T08:16:38 | http://newalbanyhighschool.org/alumni/8264488/robert-schaffer.html |
Considered one of essentially the most common electrical wiring inquiries is on how to wire a swap. Even though utilizing switches at your house is very quick, wiring just one may not be that uncomplicated for everybody. An ON-OFF switch is definitely quite simple to wire. There are actually several types of switches, but for this example, let us say you're setting up a single-pole toggle switch, an incredibly popular switch (along with the most straightforward).
You'll find 3 shades of wires in a very usual single-pole toggle switch: black, white, and green. Splice the black wire in two and link them over the terminal screws - a person on top rated plus the other over the bottom screw from the swap. The white wire serves for a resource of uninterrupted electric power and is also generally related to your gentle colored terminal screw (e.g., silver). Link the environmentally friendly wire into the ground screw of your respective change.
These methods would generally be enough to help make an average change do the job with no dilemma. Nonetheless, if you will not be assured that you just can achieve the undertaking appropriately and properly you improved allow the pros get it done in its place. Soon after all, you can find a reason why this task is one of the commonest electrical wiring concerns requested by a lot of people.
For many explanation, tips on how to wire a ceiling fan is usually amongst essentially the most typical electrical wiring questions. To simplify this undertaking, you may use just one swap for any single ceiling fan. To wire the fan, it is just a make a difference of connecting the black wire on the ceiling fan to your black wire from the switch. When there is a light-weight, the blue wire should be linked for the black wire of the switch also.
There are causes why these are generally one of the most typically asked electrical wiring queries. A single, a lot of believe it really is uncomplicated to do, and two, these are definitely the prevalent electrical responsibilities at your house. But you then must not set your protection in danger in your purpose to save money. The stakes could even be a great deal larger in the event you try to spend less and do an electrical wiring position with no sufficient information or practical experience. | 2019-04-21T04:19:51 | https://ferragamos.net/post/91279/inverter-is-there-an-ic-that-inverts-dc-ac-at-the-resonant-enter-image-description-here-lc-oscillator-circuit-diagram.html |
A homegrown wine festival taking place every month at La Ville Hotel & Suites.
Mother’s Day is just around the corner and it is time to make your mom and maternal figures feel special. Surprise, pamper and treat the woman who do it all. | 2019-04-18T12:43:47 | https://fact-magazine.com/index.php/category/things-to-do/ |
Hi! Sign in to let us know how Athens Area Pediatric Dentistry was?
If you've been to or used Athens Area Pediatric Dentistry, leave a review. | 2019-04-25T20:29:56 | http://www.insiderpages.com/b/3713224326/athens-area-pediatric-dentistry-watkinsville-4 |
With over 600 members, Hub Southern Cross is one of the Melbourne's premium coworking spaces. With beautifully designed space and all-inclusive amenities, all you need to do is move in and start growing your business. Private office and dedicated or flexible desk spaces are available, all located in the beautifully restored Mail Exchange building steps from Southern Cross Station. | 2019-04-22T13:06:23 | https://laneways.melbourne/workspaces/the-hub-southern-cross |
Welcome to the home buyers section of the website assisting buyers looking for real estate for sale in the surrounding areas of Los Angeles County. Please select from one of the real estate home buying sections below to help assist you in finding a new home to call your own.
Knowing about the local real estate market and local community information is critical. Click here to learn all about Palos Verdes Estates Estates and other Los Angeles County areas.
Click here to receive free information about buying a home in Palos Verdes Estates Estates or any other surrounding local Los Angeles County real estate markets. | 2019-04-25T20:13:27 | http://www.brokbutcher.com/buying-a-home.html |
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Draw on an interesting or strange occasion that occurred in your life.
Search the web for “writing prompts” and you should find many suggestions to enable you to get going, suggested by various other article writers.
Start thinking about version. A common number of writing is version, where the author bases the concept for piece on a preexisting work. Think about the story to a novel or film you liked that would be interesting to see taken care of in another way or with an alternative kind of closing. Make use of your imagination to approach the subject in an entirely brand-new means, so that your tasks are uniquely your very own.
The favorite 1990's teenager movie Clueless is a contemporary adaptation of ? How do you wish your audience to feel when they complete reading your piece? Can there be an important social, philosophical, or ecological idea that you would like to mention?
Salinger's Catcher when you look at the Rye contains themes of alienation and coming old.
Tolkien's Lord of this Rings series addresses motifs of courage, and triumph of good over evil.
Douglas Adams' Hitchhiker's Guide to the Galaxy plays with themes concerning the absurdity of life, the interconnectedness of all things, and just how apparently minor incidents have huge consequences.
Develop a plan. Numerous authors discover that it helps to prepare their particular piece before they begin composing. If you're writing a fiction piece, you might want to plan aside all your valuable major figures and story things. If you're writing a non-fiction piece, analysis the topic carefully then list the most important tips you want to deal with.
Dive in. don't overthink things, or perhaps you may have difficulty getting started. Knowing what you need to write, simply start composing.
Begin everywhere you like. You don't need to begin composing a piece at the beginning. You are able to work with any part of the piece that appeals to you now. You could also think of how you wish end the article or story, and consider simple tips to would like to get there.
Write yours way. If composing the complete piece seems daunting, consider writing individual scenes and then piecing all of them together as you get. The greater amount of you compose, the greater amount of familiar you'll become with the techniques that really work most effective for you. | 2019-04-26T10:02:45 | http://www.rapidhomeschool.com/CreativeEssays/creative-writing-essay-format |
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The township of Rio Rancho has hitherto not had its own emergency facilities. It has secured funds to erect two emergency facilities in 1986, each of which will combine ambulance, fire, and police services. Figure 1 indicates the demand [figure omitted], or number of emergencies per square block, for 1985. The "L" region in the north is an obstacle, while the rectangle in the south is a part with shallow pond. It takes an emergency vehicle an average of 15 seconds to go one block in the N-S direction and 20 seconds in the E-W direction. Your task is to locate the two facilities so as to minimize the total response time.
Assume that the demand is concentrated at the center of the block and that the facilities will be located on corners.
Assume that the demand is uniformly distributed on the streets bordering each block and that the facilities may be located anywhere on the streets. | 2019-04-25T22:06:46 | http://math.tongji.edu.cn/model/mcm1986B.html |
Students from several Monroe County Schools will participate in demonstrations and discussions as part of a nationwide effort to fight gun violence.
Exactly one month after a devastating shooting took the lives of 17 students and staff at Marjory Stoneman Douglas High School on Feb. 14 in Parkland, Florida, students at schools across the county, state and nation will join together in efforts to remember and honor the victims, and to stand in solidarity with survivors working to enact change to make schools safer.
Students from several Monroe County schools, including Brighton High School, Aquinas Institute, and School of the Arts, will participate in nationally organized walkouts, exiting their buildings from approximately 10 a.m. to 10:17 a.m. to call for gun control legislation and shed greater light on the issue of gun violence. Students who don't wish to participate in the walkouts will be able to continue regular school activities.
While students have planned to walk out of schools across the country for weeks, in Rochester the weather might intervene. The National Weather Service in Buffalo issued a winter weather advisory through 6 a.m. Thursday, Monroe County is expected to get 6 to 12 inches of snow.
“The School of the Arts student body is an incredibly unified community, and we really support each other and support this political movement, and were really invested in that,” said Grace Myers, a senior, who organized the student-led walkout.
“This definitely isn’t a movement against the Second Amendment, I think this movement is about bringing the Second Amendment more collaboratively into contemporary society,” Myers said.
Brighton schools Superintendent Kevin McGowan called students "engaged, bright, thoughtful and passionate," and said that the goal of the school district is to support them as educators.
"We are so proud of our students," McGowan said in a press release. "Whatever your perspectives are on the politics of these situations, we can all celebrate the fact that students are speaking out and engaging in such meaningful civil discourse."
But much like past demonstrations, plans to walk out have not gone uncontested.
In several districts, student safety remains a central concern and a point of opposition regarding the national walkout.
Some schools are working with local police departments to ensure a strong presence while students are outside, but others are discouraging students from leaving the building at all.
In Pittsford, schools Superintendent Michael Pero said that he has spent the weeks following the shooting concentrating primarily on how to best keep students safe, but that he recognizes the importance of their voices.
In a video message March 4, Pero said he was still working with students to find a way for them to be heard.
"You have grown up in an era that has seen tragedies unfold in Columbine, Virginia Tech, Sandy Hook and now Parkland, Florida. These are tragedies that no other American generation had to worry about," Pero said. "I am saddened that this is something you have to witness, process and endure. I also want to let you know that I am so proud of your response to this tragedy. You’re finding your voice and you are acting to make a positive change."
He went on to say that students have expressed a broad spectrum of thoughts, "ranging from wanting to support this organization's walkout, to experiencing anxiety about the walkout, to worrying that their peers might think less of them if they want to stay in class, to worrying that their peers might think less of them if they walk out of class.
"The consistent themes, however, that I’ve heard from you are your desires to keep schools safe, and to express empathy for all who were involved in the Parkland tragedy," he said.
In a letter March 12, Pero said that he had since met with about 200 students who shared their ideas. He then highlighted student-led activities that will take place March 14 across the various school levels.
In Pittsford elementary schools, the day will remain a normal school day, but an additional emphasis will be placed on empathy and kindness, while Pittsford middle school students will work to "discuss and determine 17 actionable acts of kindness they can each commit to as a remembrance for the 17 victims of Parkland."
In Pittsford high schools, students will be permitted to leave classes Wednesday, but only with parental permission. If a student leaves without that, normal code of conduct and attendance policy will apply.
Jori Cincotta, a Pittsford parent who’s involved with her regional and local PTA, said that she had discussed the planned activities with her child. Her ninth-grade daughter asked for permission to walk out of class, but she had to make her case.
Before any official plans were announced by the district, 15-year-old Anne Olivia Cincotta was unsure about the walkout.
But in the end, her mom declared it was her choice to make.
Anne Oliva thinks teens deserve a seat at the table when topics involve their future.
"We’re the future and if teens are not included in the talk about the future, then it’s going to get really messy," she added.
The Penfield Central School District is similarly offering students an alternative to exiting the building, encouraging students and staff members to wear red or Penfield attire to demonstrate unity as a school community.
At Bay Trail Middle School, a moment of silence will take place at 10 a.m., followed by a 17-minute period in which students will have the option to participate in a variety of activities, ranging from a making a list of 17 acts of kindness to signing up for a letter-writing workshop at a later date to express concerns to elected officials.
Penfield High School will operate on a modified schedule to avoid a loss in instruction time while allowing students time to participate in a walkout as well as activities including composing letters to their elected representatives.
At Webster Schroeder and Webster Thomas high schools, students are being given the option to participate in student-led forums that will begin around 10 a.m. During the forums, which will be held inside enclosed school property, different students will read the names of the 17 victims of the Parkland shooting.
Students at Hope Hall School in Gates will hold a remembrance ceremony for victims, beginning at 8:30 a.m. in the gymnasium.
On Tuesday morning, Fairport schools Superintendent Brett Provenzano sent out a letter to parents and guardians stating that optional activities will take place inside Fairport schools.
"This tragedy, coupled with the range of emotions inherent in this topic, has placed our schools in unique positions," he wrote. "Given the gravity of this national current event, we have an obligation to listen to our students and respond in an even-keeled, responsible and supportive manner. The compassion for the greater good of society and the advocacy demonstrated by our students has been inspiring."
Fairport High School is expecting more than 450 students to participate in student-led events, he wrote.
"As a public entity, we understand that all students will not have the same opinions. We will not politicize or advocate for any side of this issue, nor will there be anyone forced to participate or not to participate in the day’s activities," said Provenzano.
“At Odyssey Academy, students choosing to participate in the walkout will leave class at 9:58 a.m. and go to the gym,” she said.
The optional assembly that ends at 10:15 a.m. is by students, for students, as are other activities taking place across Monroe County schools.
While the March 14 walkout is being led primarily by high school students, people at local universities are joining in.
More than 40 faculty and staff from Rochester Institute of Technology's College of Liberal Arts sent out a letter to students in February expressing support for student gun-control activists.
"As educators, our responsibility is first to our students and second to the democratic institutions that depend on a well-educated, well-informed and politically engaged citizenry. We can no better fulfill this dual responsibility than by supporting our students as they organize to effect social change," the statement reads. "In the days following the massacre at their school, the students of Marjory Stoneman Douglas have become the face of this generation, and they have demonstrated that they are unafraid to lead."
It goes on to pledge support to any student, current or future, who may wish to partake in any peaceful demonstration, including that on March 14.
At the University of Rochester Medical School, students, residents and hospital workers have planned a walkout outside Golisano Children's Hospital between 10 and 10:17 a.m. for 17 minutes of silence.
Alexi Bulloch, a second-year internal medicine and pediatrics resident, is working to organize the event. Bulloch said that she heard about activities involving students at the World of Inquiry School No. 58 as well as other schools in the state and nation, and wanted healthcare professionals to have a way to show their support.
"I was just very proud of the students’ response to this issue and the efforts that they’ve been going through to voice their own opinions and stand up for their own health and safety," said Bulloch. "Gun violence is a public health issue, and as medical students, faculty, residents and nurses, many of us feel strongly that as health care providers, it is something that we should support." | 2019-04-24T11:04:16 | https://www.democratandchronicle.com/story/news/local/communities/2018/03/13/march-14-student-walkout-rochester-ny-students-parkland-shooting/419384002/ |
The CCSS writing standards dictate the student’s need to support their arguments with “valid reasoning and relevant and sufficient evidence”. Often this means research. Teaching students about choosing reputable sites and significant data has to be done frequently. Anyone can write a blog these days, but that doesn’t make him or her an expert on the subject. That being said, Google now offers a great little tool that helps with the research aspect of writing a paper.
By highlighting a word on a Google Doc, then clicking Tools ->Research, a sidebar opens, showing a Google Search of that term. Students love it, especially when told they need more supporting documentation. It will even create a citation at the bottom of the document.
CC Connection: Google Docs can help a teacher satisfy many of the writing standards. The Research feature specifically addresses these: Research to Build and Present Knowledge 7. Conduct short as well as more sustained research projects based on focused questions, demonstrating understanding of the subject under investigation. 8. Gather relevant information from multiple print and digital sources, assess the credibility and accuracy of each source, and integrate the information while avoiding plagiarism. 9. Draw evidence from literary or informational texts to support analysis, reflection, and research. | 2019-04-19T03:22:24 | http://ccedtech.com/2013/02/google-docs-research-feature.html |
Students should add any and all work they complete that they're proud of. This can range from individual or team projects, labs, experiments, writing samples, research, activities, clubs, sports, volunteer work, to extracurricular activities and hobbies. There is no limit to the number of items/entries a student or alumni can add to their Portfolium. | 2019-04-21T00:11:40 | https://help.portfolium.com/edu-platform/faqs/what-type-of-content-should-students-add-to-their-portfolios |
What are the best things to do in Santa Cruz?
I lived in Santa Cruz for four years. During that time, I took full advantage of the beautiful city, beach, and mountains.
Santa Cruz is one of those places that you fall in love with from the get-go. Santa Cruz is located in the hustling and bustling state of California, but Santa Cruz residents prefer a slower paced lifestyle that brushes off on you after spending some time there.
Walking or driving along West Cliff Drive, stopping to take pictures, and ending up at Natural Bridges State Beach for a picnic and fun is one of my favorite things to do in Santa Cruz. West Cliff Drive is a 2.75-mile stretch of sidewalk that runs right along the ocean. Locals generally spend sunny afternoons walking or cycling the length of West Cliff Drive. The path offers some breathtaking views of the Pacific Ocean and passes by some of the best beaches and icons of Santa Cruz such as the Santa Cruz Surfing Museum at the lighthouse. Catch a glimpse of seals and surfers at sea and if you're in luck and it's the season, you'll see the Monarch Butterflies at Natural Bridges.
The Mystery Spot is a gravitational anomaly that has been puzzling residents since 1939 when it was first discovered. Basically, the Mystery Spot challenges your perceptions of the laws of physics and gravity. If you’re a fan of illusions then you’ll definitely be impressed by a ball rolling uphill and water flowing upwards. Be prepared to second-guess all of your senses. Locals and tourists alike love this place due to its quirkiness and the mystery that surrounds it. It’s a great day trip for people of all ages and considered a must do if you're in Santa Cruz.
In a place that’s nicknamed “Surf City USA”, you can expect to find nothing less of the best waves in the country. And Santa Cruz locals sure love their surfing. It’s one of the favorite pastimes for residents. If you enjoy surfing yourself then you want to make your way down to Pleasure Point. It’s a world-renowned surf destination that stretches along the coast. Get a taste of the Santa Cruz surf culture by catching a wave at famous surf spots including The Hook, 26th Ave, Steamer Lane and Mitchell’s Cove. Surfing is why Santa Cruz is considered one of the best places to visit and definitely one of the best things to do.
First Friday is a recurring monthly event that celebrates the artistic culture of Santa Cruz. On the first Friday of each month you can find various happenings organized throughout town. There are numerous art exhibitions, local bands playing live and creative workshops. Locals like the event so much that most shops, museums, galleries and venues work with extended hours. First Friday has become a local tradition that isn’t going away any time soon and it's one of the top things to do in Santa Cruz if you're in town on the first Friday. Admissions are generally free so you can organize a tour around town and visit multiple venues, including the Museum of Art & History which is a First Friday must.
This is probably already on your list, but I'll mention it. The Santa Cruz Beach Boardwalk is definitely one of the best things to do in Santa Cruz. It's an oceanfront amusement park that is appreciated by tourists and locals alike. It’s the oldest amusement park in California, founded in 1907. Although one day isn’t nearly enough to see everything the park and surrounding area has to offer, it’s a good start. Take a ride on the iconic Giant Dipper – one of the oldest roller coasters in the world. Oh, and don’t forget to grab a chocolate dipped banana and root beer float from one of the food stands. You’ll love them! You can also walk to the wharf/pier from the Boardwalk and grab a cup of clam chowder in a bread bowl, yum!
A thriving neighborhood just five minutes from downtown, Westside Santa Cruz is a top destination for local wine lovers, connoisseurs of good food, and anyone looking to unwind and grab a bite to eat or a drink. Many would argue that Westside is the best place to wine and dine and with good reason. There are countless restaurants that serve anything from a simple grilled burger to a three-course gourmet meal. Dine with the locals and ask for the specialty of the house. You can’t go wrong. Westside is one of the best places to visit in Santa Cruz.
Downtown Santa Cruz is every coffee addict’s dream come true. Why? Well, Santa Cruz locals take their coffee culture very seriously. There are countless cafes just waiting to serve you a dose of freshly brewed coffee. Whether you’re looking to sit in a café that’s trendy, historical or just eccentric, Downtown Santa Cruz has the perfect place for you. The specialty coffees, gourmet sandwiches, fresh baked pastries and signature wraps are the talk of this coastal beach town. And don't forget about the delicious pizza, ice cream, or drinks at one of the signature bars. Eating and drinking downtown is definitely one of the best things to do in Santa Cruz.
I forgot to mention one very important detail. If you're a fan of hiking you are in luck. Hiking in the redwood forest in the mountains of Santa Cruz is actually the best thing to do. So if you like to hike, do some research on the different trails in the area. The best place to hike in Santa Cruz requires a 30-60 minute drive and is called Big Basin Redwoods State Park, but there are other parks and trails that are closer than Big Basin.
Have you ever been to Santa Cruz? Do you live there? Tell us about your favorite Santa Cruz experiences in the comments below. | 2019-04-24T04:24:50 | https://www.exsplore.com/blog/santa-cruz-best-things-to-do |
I am a 32 year old living in London for the past 9 years. I am a country girl at heart whose passions are running and cooking. I have been an Actor for many years and now also present films for the technology industry.
Presenting - Live as well as to camera. I am experienced in green screen and autocue. I have worked on many films within the technology and corporate sectors. | 2019-04-19T02:52:41 | https://www.mandy.com/actor/profile/amanda-brewster-1 |
Sarndra k. Jul 16 .
They do have some good gift ideas, but they are way over priced. Everytime i go their i cant find what im looking for. I wouldnt recomend going to this store, everything they carry is at wal-mart for half the price.
Kyle J. Jun 29 .
I agree the customer service at the toys r us in Yuba City is really bad. The store was mess and the sales staff was rude. I tryed to ask them a question, and they egnored me.
Jessica l. Jun 29 .
I currently found out while visiting the toys r us in yuba city. that the store manager at yuba city toys r us has her 15 year old daughter work under the table for her in the store.And they have the worst customer service out of any store i have ever been to. The products are way over priced and break as soon as you take them home. The cutomer service is horriable. and walking through the storei had 7 of the associates will hounding me to buy things and to sing up for their credit card, then again at the checkout. you are ont allowd to return your broken product unnless you have your recipt, which they do not tell you. i would not recomend this store to anyone. however i went to the Toys r us in Roseville and the service was outstanding. | 2019-04-18T19:25:42 | http://www.insiderpages.com/b/3710533451/toys-r-us-yuba-city |
After some serious discussion, our esteemed critics have named the following games as official New York Videogame Critics Circle Awards Nominees. The Awards will take place on February 11, 2014 at NYU/Poly’s Pfizer Auditorium in Brooklyn. Stay tuned for how you can get free tickets.
And a hearty congratulations to all of our worthy nominees!
Sarah Grayson -Sam – Gone Home (The Fullbright Company). | 2019-04-25T17:54:46 | https://nygamecritics.com/2014/01/03/the-nominees-new-york-videogame-critics-circle-awards-2013/ |
close charts heres an example. The main difference lies in how candlestick charts display the opening and closing price. If the real body is black or another dark color, the top of the real body likely indicates the open price and the bottom indicates the close price (I used the word likely since you can make the real body whatever color you want). Syllabus Of All Chapters, part 1: Introduction What Is Forex Trading? So if you are looking at a daily chart you will see a price bar for each day, a 4 hour chart will show you one price bar for each 4 hour period of timeetc. This Free, beginners Forex Trading Introduction Course was created to help novice traders understand all bitcoin multiplier x100 the basics of the Forex market and Forex trading in a non-boring format. Prices returned for a re-test of support on Wednesday around the fomc rate decision; but the ensuing response of USD-strength saw prices in the pair run-up to fresh weekly highs, finding a bit of resistance at the Fibonacci level around.3423. That setup filled-in fairly quickly and the first target was traded at on Tuesday of this week. Checkout Nial's Professional Trading Course here. For those looking for trading ideas, our IG Client Sentiment shows the positioning of retail traders with actual live trades and positions.
The longer-term loan would bring on considerably more risk, approximately 40 times longer than the bitcoin golfd three-month-loan, and this is pretty much why it never happens, at least on the consumer-level. The large block in the middle of the candlestick indicates the range between the opening and closing price. Traders enjoy access to more than 12,000 markets across commodities, shares, indices and forex. Professional Forex Trading Course. Lets look at an example of a daily line chart of the eurusd: Bar charts. How do these agencies help protect customers? Related lesson : Forex Charts Introduction to Forex Charting. If the firms fail to adhere to the regulators standards, the regulators can revoke these licenses. Usdcad Four-Hour Price Chart Chart prepared by James Stanley USD Strength Strategy: Bearish nzdusd on Hold Below.6950 Similar to the above in usdcad but on the other side of the US Dollar, nzdusd caught a strong bid to rally up towards a big zone. Other Tutorials Guides: How To Correctly Set Up Meta Trader Forex Charting Platform.
So toll ist der Staatdienst mav_five "Mein Bekannter arbeitet in Louisiana für den Staat. Sie ging mit zu den Ferienhäusern dieser Milliardäre und machte Bilder, wie dieser Typ mit alten Kunden rummachte. Die Lady arbeitet überhaupt nicht, aber sie..
# # The config option rpcauth can be added to server startup argument. Sample nf Copied from nf : # # nf configuration file. Can be specified multiple times. #maxconnections # # json-RPC options (for controlling a running Bitcoin/bitcoind.. | 2019-04-20T06:33:43 | http://thedigitalbakery.nl/13226-forex-cfd-university-research/ |
We have Sony factory trained technicians in our repair facility to repair your Sony DCR-PC350 camcorder and we have the most Common Replacement parts in stock. We specialize in this model camcorder and our Technicians are experts in this particular model. Our efficient, prompt service comes from factory authorized training. | 2019-04-25T17:57:05 | https://camcorderrepair.com/SONY-DCR-PC350.htm |
To meet awesome Steampunk Tweethearts and learn more about this captivating world that has me hooked!
Welcome to the Guild, Claire! Delighted you've found us, and that you enjoyed last week's #SteampunkChat. Always nice to know we're hitting the mark!
Welcome, Claire - I just joined, myself, and am very pleased to meet you!
Thank you, Claire! It's nice to meet you. I have a fondness for airships, too, and even flew on the Goodyear blimp once, back when I was doing research for a novel years ago. If you're writing about airships there is a lot of information on the internet about zeppelins, dirigibles and the like that can help give you a real feel about what their structure, weight limitations and vulnerablilities are, which can often help suggest plot possibilities or background details, and then you just have to balance the "romance" of airships against the "plausibility factor" (which doesn't mean it has to be possible, just seem possible!). I think this is an exciting time, as Steampunk is really blossoming now. | 2019-04-26T00:06:14 | http://steampunkwriters.ning.com/profile/ClaireESmith |
Relocating to back to Brisbane. Looking to move late May/early June, flexible to suit the right place/people. Jackie works full time in sales, but is an industrial designer and is looking to move back into design once were settled in Brisbane. I have my own business + I work part time whilst my business is getting off the ground. Jackie is from Brazil and we are both keen travellers. I would consider us quite social and would like to live with other(s) who are the same (understand personal space and down time as well). Often go away camping (you'd be welcome to join) but also enjoy our time in the city with our friends. We are not the type to keep you up all night partying but will have friends over from time to time. A clean and respectful couple that values others privacy and are looking for somebody who is the same. (Ideally) Looking for a place in inner north area as Jackie will be working in Windsor and does not drive. A lock up garage is essential as I need a place for my tools (undercover parking is not suitable). Own bathroom/ensuite is preferred but flexible. Starting a new sharehouse is our preference but happy to jump into a pre existing one as well if it fits.
I’m looking to join a house or connect with a few new faces, after experiencing a share house that wasn't the right fit. I usually like to keep myself busy with creative projects, outdoor adventuring and growing my plant babies. In saying that I also enjoy relaxing with a nice book, and cooking up delicious treats. Looking for like-minded, tidy and respectful housemates who might also be up for grabbing dinner together or being social when it suits.
WALKING DISTANCE TO SHOPS & QUT! Set on a quiet street on an ideal location in Kelvin Grove – walking distance to all amenities including shops, take-away and QUT Kelvin Grove. This property has 3 large bedrooms with air-conditioned lounge and shared kitchen that offers comfortable long-term living for residents. The rooms and common areas are fully furnished and fully equipped with cutleries, crockery and cooking utensils. Internet is provided on behalf of the owner. QUT KG is just at a comfortable walking distance away and Brisbane city is located 5min away by bus.. Bedrooms: 3 Bedrooms Bathrooms: 1 Bathroom Rooms Room 3 - $165 P/W - Avail 3/07/2019 Room Includes: • Fully furnished • Double bed • Desk • Chair • Built-in wardrobe Common Area: • Kitchen • Modern Lounge • Dining Area • Laundry and Toilet/Bathroom Rent Includes • Electricity • Furniture • Gardening • Gas • Water Professional monthly room cleaning • Provision of a linen pack (bed sheets x 2 & pillow cases x 2); • Replacement of the linen pack once a month (this is a collection and delivery service only and will not include making of the beds) Education Facilities Close by: • QUT (Kelvin Grove) (Victoria Park Rd) 900m; • JCU (349 Queen Street) 3.2 kms; • Sarina Russo (82 Ann Street) 3.0 kms; • Griffith University (South Bank) (Russell Street) 4.1kms; • QUT Gardens Point (2 George Street) 3.7 kms; • Shafston College (Shafston Avenue) 4.2kms, • Royal Brisbane Hospital 1.8kms Shopping Close by: • Kelvin Grove Urban Village (Nando’s, Pizza Capers, Subway, • Woolworths Supermarket • Gym, Restaurants) – 660m • KFC – 0.14km • Thai Restaurant – 0.12km • Red Rooster – 0.31km, Post Office – 0.24km Public Transport: (Zones Travelled In: 1-2) • Closest Bus Stop Bus Route - To City – Approximately 5 minutes - Routes 345, 359, 390, 372; • Bus Route – From City – Approximately 5 minutes - Routes 325, 345, 373.
Two separate Level house with fully furnished rooming accommodation. Value for Money and easy access to QUT Kelvin Grove Campus. Each level have 6 individual bedrooms, fully equipped kitchen & 2 bathrooms/toilet for share. Internet available, courteous of the owner Convenience public transport access to City & QUT Kelvin Grove Campus. Bedrooms: 6 Bedrooms Bathrooms: 2 Bathrooms Rooms Available: Room 1 Dwn - $170 per week - Available 8/07/2019 Room 3 Up - $170 per week - Available 27/04/2019 Room 4 Down - $165 per week - Available NOW Room 4 Up - $165 per week - Available 8/07/2019 Room 5 Up - $165 per week - Available NOW Room 5 Down - $170 per week - Available 28/06/2019 Room 6 Up - $170 per week - Available 4/07/2019 Common Areas: - Large open plan kitchen - Spacious lounge & dinning area - Coin Operated Washing Machine provided - Carpeted floors in side the room, Timber / Tiles in Common Area Your Room Includes: - Fully furnished with Bed - Wardrobe - Desk - Chair - Lamp Rent Includes: - Electricity - Furniture - Gardening - Gas - Professional Cleaning of Common Areas (Twice a month) - Water We also offer the below service for these rooms: Professional monthly room cleaning Provision of a linen pack (bed sheets x 2; pillow cases x 2); Replacement of the linen pack once a month (this is a collection and delivery service only and will not include making of the beds) Professional laundry services to wash the linen pack; Education Facilities Close by: - QUT (Kelvin Grove) (Victoria Park Rd) 1.2 kms; - JCU (349 Queen Street) 4.3 kms; - Sarina Russo (82 Ann Street) 4.5 kms; - Griffith University (South Bank) (Russell Street) 5 kms; - QUT Gardens Point (2 George Street) 4.9 kms; - Shafston College (Shafston Avenue) 5.3 kms Shopping Close by: - ALDI supermarket is only 4 minutes walking distance. - Woolworths Supermarket Kelvin Grove Village Approximately 1.7kms away Cafes, Australia Post, Banks, Health Food Store, etc. Public Transport: (Zones Travelled In: 1-2) - Closest Bus Stop Approximately 440 metres on Windsor Road; - Bus Route 345 -Other bus routes to and from the City from Kelvin Grove Road Approximately 10 to 15 minutes - Routes, 390, 361, 364.
BEST VALUE EVER for modern AIR-CONDITIONING ROOM!!! These 3 units are fully equipped with modern kitchen facilities and lockable cupboards. Fully furnished lounge and bedrooms with internet available to the tenant, courteous of the owner. Ideally for students studying in the City, QUT Kelvin Grove and it is also very near to the Royal Brisbane Hospital. Each unit has: Bedrooms: 7 Bedrooms Bathrooms: 4 Bathrooms (2 Ensuites; 2 Common Bathrooms, extra toilet) Living Area; Kitchen Area Common Areas Rooms Available: UNIT 1: Room 2: $190 per week - AVAILABLE 10/06/2019 - AIRCON Room 3: $185 per week - AVAILABLE 8/06/2019 - AIRCON Room 6: $180 per week - AVAILABLE 4/07/2019 - AIRCON Room 7: $180 per week - AVAILABLE 5/07/2019 - AIRCON UNIT 2: Room 7: $190 per week - AVAILABLE 24/06/2019 - AIRCON UNIT 3: Room 1: $200 per week - AVAILABLE 27/04/2019 - AIRCON Room 2: $210 per week - AVAILABLE 9/07/2019 - AIRCON Room 3: $190 per week - AVAILABLE 5/07/2019 - AIRCON Room 5: $190 per week - AVAILABLE 20/07/2019 - AIRCON Room 6: $190 per week - AVAILABLE 20/07/2019 - AIRCON Room 7: $180 per week - AVAILABLE 22/05/2019 - AIRCON Common Areas: Large open plan kitchen, Spacious lounge & dinning area, Laundry, carpeted floors throughout the property, outdoor area. Your Room Includes: Fully furnished with Bed, Desk, Chair, and Hard Wired Smoke Detector. Re Common Areas: Large open plan kitchen, Spacious lounge; dinning area, Laundry, carpeted floors throughout the property, outdoor area. Your Room Includes: Fully furnished with Bed, Desk, Chair, and Hard Wired Smoke Detector. Rent Includes: Electricity, Furniture, Gardening, Gas, Professional Cleaning of Common Areas (Twice a month), and Water. Linen service once a month. All utilities included in rent - Water, Gas, Electricity • Professional monthly room cleaning • Provision of a linen pack (bed sheets x 2 & pillow cases x 2); • Replacement of the linen pack once a month (this is a collection and delivery service only and will not include making of the beds) • Professional laundry services to wash the linen pack; • The ability to utilise our electronic payments system on-line to afford greater convenience to pay rent; and • Pastoral care and consideration welfare and accommodation standards in accordance with Federal Government’s Education Industry National Code of Practice Education Facilities Close by: QUT (Kelvin Grove) (Victoria Park Rd) 1.2 kms; JCU (349 Queen Street) 4.3 kms; Sarina Russo (82 Ann Street) 4.5 kms; Griffith University (South Bank) (Russell Street) 5 kms; QUT Gardens Point (2 George Street) 4.9 kms; Shafston College (Shafston Avenue) 5.3 km Shopping Close by: Woolworths Supermarket – Kelvin Grove Village – Approximately 1.7km away – Cafes, Australia Post, Banks, Health Food Store, etc. Public Transport: (Zones Travelled In: 1-2) Closest Bus Stop – Approximately 440 metres on Windsor Road; Bus Route 345 -Other bus routes to and from the City from Kelvin Grove Road – Approximately 10 to 15 minutes - Routes, 390, 361, 364. Don't miss this opportunity!
Hi, I'm Daphne. I'm looking for a private room which near QUT Kelvin Grove campus ^^ I'm a funny person who you would find comfortable to share the house with.
I'm looking for a place to call home from feb-nov next year while I study at QUT. I'm very relaxed and easy going, spend most of my time studying and working but enjoy hanging out with friends in my spare time too!
I will move to Brisbane in July 2019 to pursue my master degree at UQ university. I'm an open-minded person, hard working and clean. I'm also keen on cooking and playing some outdoor activities.
ALL BILLS AND UNLIMITED INTERNET INCLUDED IN RENT. This house is a beautiful classic colonial set over 2 levels. The entry level has a living space (inc. a TV), a big kitchen and a massive back deck. All but one of the bedrooms are all located on the level above. There is one shared bathroom on the top level which has plenty of storage space and both a shower and a spa bath. Each bedroom is furnished with a standalone wardrobe, bed frame, mattress and a desk. Most importantly the house is a 600m walk to QUT Kelvin Grove and a 15 minute bus ride/30 minute walk into Brisbane CBD. Bedroom 2, 3 and 4 [BEDROOM 2 AVAILABLE NOW] -All of these bedrooms are furnished with either a double or queen bed, as well as wardrobes and desks. All of these bedrooms share the large main bathroom (as described above). Each are completely private with lockable doors. Unlimited internet and all bills are included. Main Bedroom (Bedroom 1) Not currently available - This private bedroom includes an ENSUITE, aircon and built in robes. It also includes an ENTIRE OTHER ROOM to be used as a study and is completely private (i.e. not a shared space). It is fully furnished with a queen bed in the bedroom, a dresser for extra storage and a desk in the study. Unlimited internet and all bills are included for $250 p/w. The house is managed by the onsite owner directly so you won't be dealing with an agency. Your bills are all included in the rent so no need to pay extra for internet, electricity and water. Each room has a lock and you will receive your own set of keys for privacy to come and go as you please. All of the rooms are fully furnished but you're more than welcome to bring your own furniture. Each room also has a ceiling fan. There is only on-street parking available (permit area). There is an onsite laundry and two clotheshorses provided. This is a non-smoking house and no pets, sorry.
A Brisbane worker's cottage with a large back deck, located close to QUT Kelvin Grove Campus (5 min walk). Air conditioning in living room, house fully furnished, access to public transport at street ends. Large backyard and seperate laundry downstairs. No pets.
Hey I'm Sam. Just arrived from New Zealand and I'm looking for a place to stay. Im very clean,relaxed and fun person to be around. Always keen to chat and go out for a drink. Just looking for a great group of people to get to know. Cheers!
G'day everyone! My name is Stuart, but I'm commonly just called Stuey or Stu. I'm very much a homebody and like/respect privacy between roommates but I'm all for having fun together and making some fun memories with some (hopefully) soon-to-be good friends. I'm into video-games, music, movies, computers, Vegemite toast and a lot of other little things that could make up a whole list. | 2019-04-26T09:38:00 | https://flatmates.com.au/kelvin-grove-4059 |
Baptist Mission Integrated School (BMIS) is an institution of Bangladesh Baptist Church Sangha (BBCS). BMIS’s management committee forms by the BBCS. SHED Board is the social development wings of BBCS and the executive authority BMIS. The BBCS formed a school management committee with 09 members for every 04 years smoothly school operation. All the policies and objectives of BMIS control by the school management committee.
Baptist Sangha School for Blind Girls (BSSBG) began in 1977 with five blind girls at a rented house in Mirpur in Dhaka city, Bangladesh. The founder of the organization is Rev. Veronica Ann Campbell. Christofel Blinden Mission (CBM)-Germany was the founder partner of BSSBG. From January 2007, an inclusive education for both blind and sighted children started, and the name of the school has been changed to its present name, Baptist Mission Integrated School (BMIS).
The Institution has been providing services for the past 30 years to the visually impaired girls as well as women in Bangladesh, and even now, it is the only residential school for blind girls in Bangladesh. The Institution has continued its services with assistance of BMS (Baptist Missionary Society)-UK, MODEN-Japan, Alcester, Dark and Light and other friends at home and abroad. The institution is a non-profit organization for visually impaired girls, destitute children and women, orphans, and the most neglected in the family and society. The institution invites and welcomes all blind girls aged 5 to 18 years irrespective of caste, creed, or religion. | 2019-04-18T21:08:56 | http://bbcs.org.bd/institutions/school/baptist-mission-integrated-school,-dhaka.html |
Five children aged between 7 and 11 were among a group rescued after they were cut off by the tide in Cornwall.
The children were with three adults and were caught in a small cove near to Porthcothan, on the north coast by Padstow.
Another swimmer was also picked up in the operation, which took place on Monday at around 4.15pm.
Coastguards were alerted and the Padstow and Newquay RNLI inshore lifeboats were sent out.
A Padstow RNLI spokesman said: "The RNLI crews were guided into the cove by Padstow coastguards on the cliff-top. The two families were transferred to safety on both inshore lifeboats, along with a young boy who had been rescued by a RNLI lifeguard after getting into difficulties while swimming nearby. Our lifeboats returned to Newquay Harbour around 6pm." | 2019-04-26T05:53:09 | https://www.cornwalllive.com/news/cornwall-news/five-children-caught-rising-tide-360177 |
Baumholder, Rhineland-Palatinate, Germany is one of the most visited cities in the country and has good road conditions for self-driving. EasyRentCars provides our guests with the Best Price Guarantee policy and 24/7 online customer service. It can be never easier than searching for a rental car that suits your needs and budget and making a booking online with us. We have partnered with global and local car rental companies in more than 200 countries and are still constantly expanding our partnerships with quality car rental brands, to offer you the widest choice of car rental deals worldwide.
Service code: 9842327111 | © 2019 Easy Tour International Ltd. All rights reserved. | 2019-04-22T04:25:24 | https://www.easyrentcars.com/locations/cities/car-rental-baumholder-city-rhineland-palatinate-state-germany |
Dear John – how can I pay off my home loan faster?
Q: I have a $475,000 25-year mortgage which I’m paying off monthly at a standard variable rate of 4.6%. While rates are low I want to try and pay off as much of my mortgage as possible. Do you have any tips or tricks on how to get ahead on my mortgage while interest rates are low?
A: Using a home loan repayment calculator I worked out you’re paying around $2,667 per month on the standard variable rate of 4.6%.
There are some basic strategies that can be used to help you pay off your mortgage faster. Simple things like tweaking your repayment frequency or paying a small amount extra in each repayment can make a big different to the length of your home loan and how much interest you pay overall.
Consider switching to a fortnightly repayment. By paying half of your normal monthly repayment fortnightly, because there are 26 fortnights each year it’s the equivalent of making an extra months’ repayment each year. This would make your repayment approximately $1,230 each fortnight.
Based on your loan size and interest rate, if you make fortnightly repayments and pay an extra $50 each fortnight, you could save $26,025 in interest and shave one year and eight months off your loan term.
If you have any money in a term deposit or savings account, it might be worth considering whether the interest you’re getting there is better than the interest you’d save if this money went on your mortgage. Putting your tax return or annual bonus on your mortgage as a lump sum payment can also make a big difference and help to further reduce the term of your loan and interest paid overall.
If you still want to be able to access those savings I mentioned above, putting it into an offset or redraw account will still reduce the interest charged on your loan but will also mean that money is still accessible to you, should you need it.
Avoid paying high fees and ongoing charges on your home loan. There are so many products out there which don’t attract ongoing monthly or annual fees and charges, so shop around. A loan’s comparison rate will give you an indication of the true cost of a loan, including most fees and charges.
Many variable rate loans come with frills, features and flexibility that you may or may not need, but end up paying for with either higher fees or a higher interest rate.
A mortgage broker can help you find the right home loan for your needs, whether that’s so it can be structured for flexibility so you can make extra repayments, or fixed so you know exactly what your repayments will be.
Dear John – how can I get ahead on my mortgage repayments? Dear John – how does the RBA cash rate affect me and my home loan? Dear John – is it better to have an investment unit in the city or a house in the suburbs? Dear John – what are your predictions for the year ahead? | 2019-04-20T06:26:39 | https://www.aussie.com.au/blog/dear-john-how-can-i-pay-off-my-home-loan-faster/ |
Interior Decorator Pros Interior Decorators are located in Lelia Lake, TX. You can pay us a visit or you can call us on 844-244-6399. Whatever you find comfortable with you is fine with us. Whether you give us a call or you come to our office, we will help you out in any interior decoration services that you might be in need of. You will have all your questions answered and get important advice on interior decoration for your home or business.
Interior Decorator Pros Interior Decorators in Lelia Lake, TX is a legally licensed interior decoration company that has been in the industry for several years serving, residents, large and small businesses in Lelia Lake, TX. We have built a reputation in interior decoration thus we are the best that you can find in Lelia Lake, TX. We offer quality services in a professional way. We are experienced and skilled enough to carry out any interior decoration.
Interior Decorator Pros Interior Decorators can also offer interior decoration for occasions and events. If you are having a party or a wedding, Interior Decorator Pros Interior Decorators in Lelia Lake, TX will help you make that day memorable by providing you with top quality interior decoration. We can also advice you on what is best for the occasion and what is not ideal for that occasion. You might be a call away from getting the best interior decoration services you have ever experienced. Call us and talk with our customer care service personnel who will advice you accordingly and get you a budget friendly quote for you.
Lelia Lake, TX is a great place to live. Many people who move in to Lelia Lake, TX never want to move out, most of them build homes and spend their lives here. If you are new here, you must be having a great experience. Many new owners in Lelia Lake, TX are in continued search for ideal Interior Decorators that can help them in interior decoration of their homes. Spending time browsing through the internet in search for an ideal Interior Decorator company is not only tiring but it is also time consuming. If you are one of these home owners, then search no more since Interior Decorator Pros Interior Decorators are here to help you out in all your interior decoration needs for your home.
Interior Decorator Pros Interior Decorators is a group of experienced Interior Decorators who have come up to form a company that aims to help clients in Lelia Lake, TX in interior decoration. Whatever interior decoration design you are looking for, we will make sure that you get what you want at an affordable price. We plan on expanding our business to other states but for now our services are only available for people living in Lelia Lake, TX and the surrounding areas. When you call that number you will get any information that you need to know on residential interior decoration and commercial interior decoration. | 2019-04-18T20:34:31 | http://www.interiordecoratorpros.com/tx/interior-decorator-in-lelia-lake/ |
The detail of this herb box appears as though a layer has eroded and flaked away here and there. This petite planter is the perfect size and shape for window sills and ledges.
Suggested plant size is seeds or 2″ and container is plumbed for direct planting. | 2019-04-25T06:32:15 | https://dsgardenshop.com/product/terra-relic-herb-box-small/ |
Tom Kruskal’s jewelry is completely hand fabricated using a cold forging technique followed by heat treating; this process allows the jewelry to be remarkably graceful and sculptured – yet exceptionally strong.
The high polish found on Tom’s jewelry is accomplished by the use of a specially made mirror finish anvil that is struck by a polishing hammer. The result is beautiful jewelry that is light in weight yet remarkably strong and resilient, with style of grace, elegance and wearability.
Tom’s designs are rooted in his interest in mathematics and music – which lend a sense of proportion, balance, movement and grace to his work. The designs are all original and grow out of hours of his personal experimentation. | 2019-04-26T14:15:30 | https://www.kullbergjewelers.com/jewelry-collections/tom-kruskal-designs/ |
BJP candidates Mala Rajya Laxmi Shah and Tirath Singh Rawat filed their nominations Friday from Tehri and Pauri Lok Sabha constituencies of Uttarakhand, which goes to polls in the first phase on April 11.
DEHRADUN: BJP candidates Mala Rajya Laxmi Shah and Tirath Singh Rawat filed their nominations Friday from Tehri and Pauri Lok Sabha constituencies of Uttarakhand, which goes to polls in the first phase on April 11.
Shah, a two-time MP from the seat, filed her nominations before returning officer S A Murugesan here in the presence of Chief Minister Trivendra Singh Rawat, family members, party MLAs and Dehradun Mayor Sunil Uniyal Gama.
The chief minister, MLAs and party leaders accompanying her to the collectorate in a jeep were wearing headbands with 'Main Bhi Chowkidar' written on them.
Bearing party flags and shouting slogans in support of Prime Minister Narendra Modi, BJP workers followed her in the form of a procession through the streets as she started from BJP's city office to file her nominations at the collectorate.
The party MLAs, who accompanied her to the nomination centre included Harbans Kapoor, Ganesh Joshi, Umesh Sharma Kau and Vinod Chamoli.
Her husband Manujendra Shah, daughter Shrija and son-in-law Kirti Shah were also with her.
Mala Rajya Laxmi Shah, who is the daughter-in-law of the erstwhile Tehri royal family, first won the seat in a bypoll in 2012 defeating Congress's Saket Bahuguna, son of former Uttarakhand chief minister Vijay Bahuguna.
She won it again in 2014 against the same opponent.
The party has renominated her from the seat for the third consecutive time.
Tirath Singh Rawat, a former MLA and minister who is contesting the Lok Sabha polls for the first time, also filed his nominations from Pauri later in the day.
After offering prayers at Pauri's Lakshmi Narayan temple, he left with the chief minister, party MLAs and leaders for the office of returning officer Dhiraj Garbyal to file nominations.
Tirath Singh Rawat, who was pradesh BJP president before Ajay Bhatt took over, has been fielded by the BJP from Pauri in place of sitting MP B C Khanduri.
Rawat, who is considered a protege of Khanduri, is likely to battle it out with Khanduri's son Manish Khanduri, who recently joined the Congress at party president Rahul Gandhi's rally here.
Though it has not yet been announced, Manish Khanduri's candidature from the seat is considered almost final.
"These elections are being fought on the issues of development and nationalism and people will give their support to the BJP to strengthen the hands of Prime Minister Narendra Modi," Chief Minister Trivendra Singh Rawat said in Pauri.
The BJP, which has all the five Lok Sabha seats from Uttarakhand in its kitty at present, renominated its sitting MPs from three while deciding to gamble on new candidates from two Thursday evening.
The three renominated candidates are Mala Rajya Laxmi Shah from Tehri, Ramesh Pokhriyal Nishank from Haridwar and Ajay Tamta from Almora, whereas the two new candidates are Tirath Singh Rawat from Pauri and pradesh BJP president Ajay Bhatt from Nainital.
Bhatt has been fielded in place of Bhagat Singh Koshiyari.
Rest of the candidates, including Nishank, Bhatt and Tamta will file their nominations on the last date of nominations on March 25, pradesh BJP media chief Devendra Bhasin said. | 2019-04-25T20:04:12 | https://www.thehansindia.com/news/national/uttarakhand-mala-rajya-laxmi-shah-tirath-singh-rawat-file-nominations-514349 |
Onset Narrowing of the pulmonary valve is usually present at birth (congenital). and it is a condition developed during the fetal life. The cause is unknown, but genetics may play a role. It may be isolated pulmonary stenosis or combined with the other heart lesions.
Shortness of breath on exertion In pulmonary stenosis, there is an obstruction to the blood flow from the right ventricle to the pulmonary artery due to narrowing of pulmonary valve. Areas of narrowing would be below the valve, above the valve or pulmonary valve itself which is the commonest. There is thickening and fusion of the valvular commissures. There are 3 types of pulmonary stenosis, the typical dome-shaped pulmonary valve is characterised by a narrow central opening with a preserved, mobile valve, the dysplastic pulmonary valve is less common, the unicuspid or bicuspid pulmonary valve is generally a feature of tetralogy of Fallot. Lowered cardiac indices before and after exercise in adults with severe pulmonary stenosis. can cause shortness of breath.
Risk factors:-History of atrial fibrillation Pulmonary vein stenosis is a late complication of radiofrequency ablation for atrial fibrillation, frequently asymptomatic and it can be associated with severe respiratory symptoms that cause significant morbidity.
Risk factors:-History of rubella in mother during antenatl period Babies born to mothers who had rubella (German measles) during pregnancy were more likely to develop pulmonary stenosis along with deafness and patent ductus arteriosus.
Risk factors:-Rheumatic fever This is a complication of an infection caused by streptococcus pyogens, and patient may have a history of sore throat, skin sepsis followed by fever. Rheumatic fever may injure the heart valves causing stenosis.
Dysmorphic features Pulmonary stenosis is the most common cardiac anomaly in Noonan patients. Features of noonan's syndrome include congenital heart defect (typically pulmonary valve stenosis) also ASD, hypertrophic cardiomyopathy, short stature, learning problems, pectus excavatum, and a characteristic configuration of facial features including a webbed neck and a flat nose bridge.
Cyanosis When there is a severe obstruction in the pulmonary valve, right ventricle can not eject sufficient blood to the pulmonary artery, oxygen saturation can not be maintained at normal level. There can be associated ASD or a substantial increase in right atrial pressure and right-to-left shunting through the foramen ovale, causing blue discoloration of the body due to lower oxygen levels.
Irregular pulse Arrhythmias can exist. Patient can present with atrial fibrillation and other tachyarrhythmias.
Hypertension There can be associated hypertension as a comorbid factor.
Features of right heart failure: Ankle oedema, sacral oedema, ascites, hepatomegally, elevated jugular venous pressure Pumping of the right ventricle against increased pressure causes thickening of the muscular wall and right ventricular hypertrophy. Eventually, the heart becomes stiff and may become weakened causing right heart failure.
Features of pulmonary hypertension:-Loud second heart sound, wide split second heart sound This is due to associated peripheral pulmonary artery stenosis. Patients who had a systemic–to–pulmonary artery shunt as a child may have branch pulmonary artery stenosis at the site of the anastomosis.
Murmur There can be ejection click or a ejection systolic murmur, which is best radiates to the left shoulder. In severe pulmonary stenosis, the murmur become longer and second heart sound will become inaudible .
Early diastolic decrescendo in pulmonary regurgitation Pulmonary regurgitation is due to the leakage of blood back into the right ventricle after repair. There will be early diastolic decrescendo murmur at the left sternal edge and a Graham Steel murmur if associated with pulmonary hypertension and mitral stenosis.
Atrial septal defect On auscultation, systolic outflow tract murmur, wide and fixed splitting of S2, but there is no ejection click as in pulmonary stenosis[1,7].
Aortic valve stenosis On auscultation, ejection systolic murmur in upper right sternal border, radiating into carotids.
Innocent murmur Usually patient is asymptomatic.On auscultation, soft systolic murmur, usually shorter than with pulmonary stenosis and no ejection click.
Tetralogy of fallot This condition is comprised of 4 elements. Overriding aorta, right ventricular hypertrophy, infundibular stenosis and ventricular septal defect. Patients usually present as neonates, with cyanosis of varying intensity. The aetiology is multifactorial, but there is an association with untreated maternal diabetes, phenylketonuria, and intake of retinoic acid. Cyanosis more prominent than in pulmonary stenosis and no ejection click[5,6].
Right bundle branch block This shows rSR pattern on ECG.
Echocardiogram This investigation demonstrates the pulmonary valvular stenosis, condition of the other valves and associated valvular lesions and any septal defects such as atrial septal defect or ventricular septal defect. This may be normal in the presence of mild pulmonary stenosis. With moderate-to-severe pulmonary stenosis there will be enlargement of the right ventricle and thickening of its muscle[4,5].
Electrocardiogram There will be features of severe obstruction such as right atrial enlargement, right-axis deviation, and right ventricular hypertrophy. T inversions and ST depressions may be there extending to the chest lead V6[3,5].
Chest X-ray In isolated pulmonary stenosis, the hypertrophy may be hidden within the cardiac shadow and of the heart is very small. So, when there is a visible enlargement of the cardiac shadow, it has to be taken seriously. The heart size on chest x-ray is normal unless there is an associated cardiac lesion. Vascular fullness in the left lung base greater than the right base (Chen’s sign), dilatation of the main pulmonary artery are some of the findings. Calcification of the valve may rarely be seen in older patients. Right atrium may also be enlarged.
Cardiac catheterization Cardiac catheterization is rarely necessary for diagnosis. Cardiac catheterization is a test used to measure pressure and blood flow in the heart's chambers and in the great vessels, examine the arteries of the heart, perform a biopsy on the heart muscle repair the certain types of heart defects, open a narrowed (stenotic) heart valve and angioplasty with or without stenting. A peak right ventricular systolic pressure of less than 35 mm Hg and a systolic pulmonary valve gradient of less than 10 mmHg are considered the upper limits of normal. Angiography helps define contractile function, the presence of infundibular obstruction, and mobility of the pulmonary valve.
MRI and CT scan Magnetic resonance imaging and CT scans are sometimes used to confirm the diagnosis of pulmonary valve stenosis. These studies do provide excellent imaging of the main, branch, and peripheral pulmonary arteries and are useful when there is associated lesions such as pulmonary regurgitation or tricuspid regurgitation.
Angiography Angiography of the pulmonary artery can assess the degree of pulmonary regurgitation and any stenotic lesions in the main, branch, or peripheral pulmonary arteries.
Full blood count Anaemia (low haemoglobin) needs correction as it may be an aggravating factor for heart failure. There may be features of associated complications such as infective endocarditis (Neutrophil leucocytosis, low platelets).
Echocardiogram and doppler studies These patients after balloon valvotomy, should be followed up for the development of pulmonary regurgitation and re-stenosis . Doppler studies and echocardiographic evaluation is important during this follow up. Degree of pulmonary regurgitation right ventricular pressure, size, and function and tricuspid regurgitation are assessed by echocardiography[1,2]. Repeat balloon dilatation has to be performed in some patients and surgical intervention is needed for subvalvular or supravalvular stenosis in small number of patients. Age, balloon to annulus ratio, and valve anatomy were not significant predictors for the late development of moderate and severe valve regurgitation[4,5].
Electrocardiogram There will be regression of right ventricular hypertrophy( on ECG after balloon dilatation), However, evidence of hemodynamic improvement in ECG does not become apparent until 6 months after valvuloplasty. features of right ventricular hypertrophy may be reversed, but sometimes features of right ventricular strain such as T inversions may be not settling.
Chest X-ray After pulmonary valvuloplasty the heart size should be normal on chest x-ray. A progressively increasing heart size should prompt the search for pulmonary regurgitation or another lesion. The development of atrial arrhythmias should also prompt a search for residual hemodynamic lesions such as pulmonary regurgitation.
Cardiac magnetic resonance (CMR) The excellent visualisation of the RV outflow tract with CMR facilitates easy identification of the site and severity of pulmonary stenosis.
Physical activities If the patients have only mild-to-moderate PS, there is no need for limit the physical activities. If it's severe, need to limit activity until the valve is dilated or replaced as the there is a risk of arrhythmias. Patient should get advice from the doctor before any exercising programme.
Medical follow-up Medical follow-up is important to check for the symptoms or problems related to. In mild or moderate, patient need ongoing follow-up.Also need opinion from a Cardiologist before any surgery or invasive procedure.
Prevention of endocarditis No need of taking antibiotics to prevent endocarditis unless the patient had endocarditis in the past or had valve replacement with a prosthetic material. People who had valve replacement need preventive antibiotics before dental and other procedures.
Pregnancy Pregnancy will be well tolerated in mild or moderate PS.But in severe PS, it is considered as a high risk. In these cases cardiologist's opinion should be taken during the pregnancy and delivery.
Diet Balanced healthy diet is necessary for these people. A diet that is low in sodium, refine sugar, cholesterol and saturated fat is important to reduce the cardiovascular risk factors. Adding fruits ,vegetables , fish and whole grain is beneficial.
Quitting smoking Smoking is a significant risk factor for heart disease.
Percutaneous Balloon Pulmonary Valvotomy Indicated in moderate to severe pulmonary stenosis with a peak-to-peak gradient >50 mmHg with normal cardiac index. Previous surgery and pulmonary valve dysplasia are not contraindications for balloon valvuloplasty[4,5]. This procedure is also applicable to pulmonary stenosis associated with other complex cardiac defects and stenosis of bioprosthetic valves in pulmonary position. The procedure is usually performed from the right femoral vein. The technique involves positioning one or more balloon catheters across the stenotic valve, usually over an extra-stiff guide wire and inflating the balloons with diluted contrast material, thus producing valvotomy. Balloon valvuloplasty generally reduces the peak systolic pressure gradient by more than 50 per cent. The currently recommended balloon/annulus ratio is 1.2 to 1.25. Predictors of restenosis include balloon/annulus ratio <1.2 and immediate post-valvuloplasty gradient >or=30 mmHg.
Surgical Pulmonary Valvotomy or Valve Replacement In patients with pulmonary stenosis and significant valvular regurgitation, valve replacement may be required. Mechanical valve replacement is rarely used because of concerns regarding thrombosis and the potential need for measurement of pulmonary pressures. Mechanical PVR can be considered in selected patients who have had multiple previous operations and are undergoing warfarin therapy because of another mechanical valve prosthesis(6). Percutaneous balloon valvotomy thus appears to be an excellent alternative to surgical valvuloplasty or valve replacement in most patients with classic, doming, valvular pulmonary stenosis. Its use in patients with a dysplastic valve is much less established. Mortality and morbidity rates are generally higher after surgery[2,5,6].
Stenting PVS stenting with stent sizes >or=10 mm seems to be an adequate therapy modality for treatment of severe acquired pulmonary stenosis. Example of one such aquired condition is severe pulmonary vein stenosis after catheter ablation of atrial fibrillation. | 2019-04-26T00:33:13 | https://www.explainmedicine.com/article/Cardiovascular/Pulmonary-Stenosis |
operations. An efficient drive train minimizes manual effort, while double enclosed brake cover, standard slip clutch, and double pawl springs enhance performance and reliability.
8-foot standard lift (12-foot for 10 Ton and greater), nonstandard lifts and hand chain drops are also available. | 2019-04-18T22:17:17 | http://wirerope.net/jrsent/cb-hand-chain-hoist/ |
ACCENT: Adjusts the pick attack and brightness before the signal is overdriven.
CONTOUR: Brightness of the output.
Current draw: 10 mA at 9V DC approx.
6F22 9V battery or DC eliminator 2.1 mm plug center negative and positive sleeve. When LED dims, it is time to change the battery. | 2019-04-19T14:21:05 | https://www.musicjunction.com.au/product/mad-professor-simble-overdrive-pedal/ |
, copper fittings, stainless steel fittings, brass fittings, ductile iron fittings or plastic pipe fittings, regardless of what you are looking for, you can count on us to have a plumbing fitting solution for your job. You can also find thousands of pipe flanges, bushings, caps, and clamps. That’s why when professional plumbers and tradesmen need to buy pipe fittings, they come to Ferguson.com. We make it easy to find pipe fittings online. You can shop by material, like carbon steel fittings & flanges, stainless steel fittings & flanges and plastic fittings & flanges, and you can shop by brand. We carry Tylok International, Charlotte Pipe & Foundry, Elkhart Products, Anvil International, PROFLO and Sioux Chief. You can also choose by product shape, size, and schedule. Tackle your job and find the right fitting with Ferguson.com.
At Ferguson, we know pipe fittings. Whether you’re looking for PVC fittings, copper fittings, stainless steel fittings, brass fittings, ductile iron fittings or plastic pipe fittings, regardless of what you are looking for, you can count on us to have a plumbing fitting solution for your job. You can also find thousands of pipe flanges, bushings, caps, and clamps. That’s why when professional plumbers and tradesmen need to buy pipe fittings, they come to Ferguson.com. We make it easy to find pipe fittings online. You can shop by material, like carbon steel fittings & flanges, stainless steel fittings & flanges and plastic fittings & flanges, and you can shop by brand. We carry Tylok International, Charlotte Pipe & Foundry, Elkhart Products, Anvil International, PROFLO and Sioux Chief. You can also choose by product shape, size, and schedule. Tackle your job and find the right fitting with Ferguson.com. | 2019-04-23T08:21:48 | http://displayedright.com/ase/photogrid.php?action=show_item&item=61690&store=12591 |
the evergreen rainforest and the forest edge where it hunts lizards, insects, and smaller birds.
Immature crested caracara with black vulture.
Jackie caught this amazing sequence. Two caracaras grooming each other. Then a vulture joins in. | 2019-04-19T15:26:51 | http://elstonhill.com/Pantanal6.html |
Ink Depot offers a great range Toner Cartridges for your Dell E525w device with high quality products at very competitive prices. We offer a 100% money back guarantee for all consumables you have purchased from us and with 98% of our advertised products in stock, you can be assured of a speed delivery.
Your Dell E525w takes the following Toner Cartridges / Accessories: D525 Black, D525 Cyan, D525 Magenta, D525 Yellow.
All products sold by Ink Depot are supported by a 100% money back guarantee. If you are not entirely satisfied with the performance of your E525w printer consumables then we will gladly offer you a refund, credit or replacement. This guarantee is valid for up to 90 days after the date of your purchase. For further details about the terms and conditions of this guarantee offered by Ink Depot please see our see returns policy.
How fast will your Dell E525w consumables be delivered to you?
If you are looking for an updated driver or an instruction / user manual for your E525w printing device, please check the Manufacturers' website. | 2019-04-22T10:01:17 | https://www.inkdepot.com.au/dell-e525w-toner-cartridges-printer-prn-6730.html |
If you want to generate traffic through search, it’s best to do keyword research before you start writing. This way, you can focus on keywords for which a certain amount of search volume already exists – in other words, write toward topics that people are already searching for information about. If your blog lists your individual posts in order of the date that they were published, like most blogs do, then the older your blog post gets, the lower down the website architecture it goes. Simply put, engagement is the ability to hold a user’s attention. In SEO terms, it is a measure of the amount of time spent on a page. Although Google hasn’t officially declared it, there is evidence to suggest that this search engine giant does reward sites with strong user engagement with higher page ranking. Make sure that your code is valid, in some instances bad code can lead to search engines not being able to properly read a page. Use the W3C validator to check your markup.
You have to keep in mind that in order to have people purchase or sign up with your products and services, you have to convince them first. You would know if a person is almost convinced if he is constantly revisiting your site from time to time. To have a person revisit your site, you need to give him reasons to; and, one of which is by providing the site with new and updated content. A Private Blog Network (PBN) is a network of authoritative websites used to build links to your money website(s) for the purpose of ranking higher in the Google search engine. Make it easy for users to distinguish between regular text and the anchor text of your links. Your content becomes less useful if users miss the links or accidentally click them. Most SEO firms will tell claim it takes 4 to 6 months to start seeing results. It varies wildly but that’s generally in the ballpark for most projects. Note that SEO results are cumulative & escalate over time. If you’re getting positive results after 6 months these will compound after 12 months & re-compound thereafter. The most profitable relationships I’ve entered into with businesses have lasted for over 5 years during which time their fortunes have literally exploded.
For those seeking to sway public (or private) opinion about a particular topic, SEO can be a powerful tool. By promoting ideas and content within the search results for queries likely to be made by those seeking information about a topic, you can influence the perception of even very large groups. Think of new ideas to expand your content, or even to invest in evergreen content, and make sure you think like a reader, rather than a search engine. Don’t just stuff your keywords in willy-nilly and then tack on your city and state (or region or county) at the end. Remember that in addition to conveying to Google the terms for which you want your business to be relevant, these are the phrases that your prospective customers will see when they’re searching. Search engine guidelines help us distinguish truly useful content from content that was created for the sake of earning traffic from search engines. When a Website is downgraded by search algorithms, penalized by spam teams, or deindexed completely, a good question to ask is which pages on the site are earning traffic from other sources and why?
If you’re not able to rank on the first page, try to write another article, focused on a (even) more long tail keyword. Make it a little bit more specific, more niche. And see how that goes. There are many on-page elements that go into optimizing a piece of content for the search engines – such as title tags, keyword placement, using multiple content types, topic modeling, etc. As you know, back in the day we could build 10,000 forum profile links with exact match anchor text and rank in a few days. Unfortunately many SEOs have not changed their game to keep up with Google changes. Now 80% of your links should be brand/URL links, 10% KW links, and the other 10% long tail/nonsense KWs. Also, if you're just starting out, build less than 50 links a day. Gaz Hall, an SEO Expert from the UK, said: "If a blog or web site doesn’t use the NoFollow tag, the search engines acknowledge the link; if a site does use the NoFollow tag, the search engines do not acknowledge the link. "
It’s also important to know what kinds of link-building strategies to avoid, so that you don’t waste your valuable time and effort doing something that can make Google sandbox your site (remove it from their search engine). f someone is more actively seeking something then it’s more likely they’ll search longer strings of words, meaning that you will target people who will be more willing to engage with your content. If you’re selling goods or services, then targeting long tail keyword can really make a big difference. If you optimize your meta descriptions with clear and attractive extracts on what potential visitors can find on your site, it becomes easier for them to see if the information they’re looking for is on that page. Keyword density (SEO) is the percentage (%) of times a keyword or key phrase appears on a web page in comparison with the total number of words on the page. | 2019-04-20T16:11:06 | http://ww2.karakasa.com/Is-your-website-too-Dynamic-for-SEO--1517841859.html |
Hello and welcome Ladies!!! This is as you already know the Gossip Cafe, and you are free to do here as you please including using colorful languge but please wipe your goddam feet when you come in.
Hmmmmmmm... I would love to share the gossip in MY school but apparently no one will understand. Soooo im not gonna say anything.. | 2019-04-18T11:13:31 | http://online-bungalow.forumactif.com/t6-welcome |
Our Event Hosts lead and consistently “wow” customers across the Sacramento area! This role goes beyond teaching – it requires the perfect combination of performance and creativity colored by your own authentic style. As a Host you are an extension of our brand; it is your responsibility to lead the party where people come together to escape the expected and share in fun, creative experiences. | 2019-04-21T02:21:56 | https://www.yaymaker.com/about-us/careers/job?jobId=oaii9fwD |
By: mahershalal on April 8, 2019, 10:43 a.m.
I'm Leo from the Hague NL. I haven't played Go for about fourteen years (!), and about a month ago decided to start playing again. It's my ambition to study much more seriously than last time and maybe manage to become a SDK in about a year.
I've been paying on OGS as mahershalal, and I'm hoping to ask for reviews on OSR because that seems a good way to improve. Also, I'm really interested in the possibility of finding a teacher through OSR, but I'm not sure how that would work.
By: korni on April 8, 2019, 8:31 p.m.
But don't forget to have fun while being in OSR! And if you have any more questions, just fire away!!!
By: mahershalal on April 10, 2019, 9:02 a.m.
Thanks for your reply! I'll definitely look for teaching games and reviews on discord. | 2019-04-21T14:36:55 | https://openstudyroom.org/forum/forum/introduce-yourself-10/topic/hello-from-the-netherlands-209/ |
Thanks for your interest in What Is Backpack On Clickfunnels!
In this day as well as age, the way your business runs online can make or break you.
The fact of the matter is, however, that sites have dramatically advanced over the previous decade – and the methods of old are no longer useful for modern business.
Back in the day, it would certainly be enough to have a simple website with a home page, solutions, prices, about us, as well as speak to pages.
A prospective consumer would certainly most likely to your site, scroll about, see the various web pages and eat web content as they please.
Nevertheless, if you are a company investing any kind of money on advertising, you wish to control just what customers are learning more about on your site, existing offers at the right time, and also make best use of the earnings you make from each person.
ClickFunnels is the easiest way to make high converting sales and marketing funnels.
It is an one-of-a-kind device created specifically to turn prospective consumers right into customers.
It actually is an all-in-one service to create sales funnels and also includes touchdown pages, email combination, invoicing, webinars, subscription sites, therefore far more. Not surprising that it has promptly end up being a preferred device for marketers.
Below is my comprehensive ClickFunnels Review, consisting of favorite attributes, rates, pros/cons, as well as contrasts versus competitors.
What Is Backpack On Clickfunnels: Yet First, Exactly What Is a Sales Funnel?
Sales funnels (also called advertising funnels) are multi-step projects that are designed to move potential prospects via your sales procedure, as well as turn them right into customers.
Photo a real-life channel. At the top, you put liquid in, which narrows down to one repaired destination.
In sales, a comparable occasion happens. At the top, visitors come to your internet site, but not all that go into make it out of the other end as customers.
Numerous points need to occur from the moment a site visitor enters your channel, to the time they do something about it and efficiently complete a purchase.
By breaking down the client’s trip into smaller actions, you can be a lot more accurate regarding just how when you present an offer to your target market.
Web page communicates the very first offer (something complimentary to collect an e-mail).
As soon as email is gathered, major deal is pitched.
ClickFunnels likewise has a graphic that discusses this in an easy means:.
As stated earlier, ClickFunnels is the most effective sales funnel software application around today.
The firm makes the bold claim of offering you everything you have to market, sell, and supply your items online – and they absolutely supply.
But ClickFunnels takes care of everything with their platform. You not just conserve a ton of cash by not needing to acquire various products/services, but you also avoid the technical mess of having to set every little thing up, as well as can concentrate on just what’s truly crucial – growing your company.
ClickFunnels provides a Cost-free 14-Day Trial, so you get to explore the tool and truly see if it’s ideal for your organisation.
* Rapidly Produce Pages Using Layouts as well as Components *.
Prior to getting as well much, it is very important to understand that a funnel is a collection of web pages put together in a calculated order, with the objective of transforming as lots of potential customers into clients. As well as a web page is merely a collection of numerous aspects made to get someone to take a particular activity.
ClickFunnels provides more than 50 different elements to help you develop the excellent web page. The editor is incredibly very easy to utilize and all you have to do is drag and also go down various components on the web page, and upgrade the text and also appearance to fit your demands – no coding skills required!
ClickFunnels likewise makes your life less complicated by supplying you with a lots of totally free themes.
The pre-built design templates are completely customizable, as well as are exactly what most users use.
You have the ability to pick a template, modify or change the components with your own, as well as your new page prepares to go.
You could also link any type of channel you produce with your personal email marketing service (if you don’t utilize the one included in ClickFunnels), as well as utilize the ClickFunnels constructed in billing system.
* Produce One-Click Subscription Sites *.
Among the best attributes with ClickFunnels is the capacity to quickly create subscription websites and provide web content to your audience in one location.
Your subscription site will come complete with registration pages, membership access pages, as well as content web pages which you could quickly lock or trickle feed to your consumers inning accordance with acquisitions they made in your channel.
ClickFunnels subscription sites permit you to send emails, conveniently handle your e-mails, as well as develop an area all while removing the stress and anxiety that’s associated with various other solutions such as Kajabi, or WordPress platforms.
It’s really handy to not need to get a different software application or plugin to develop subscription sites.
With every funnel comes e-mail listing building possibilities.
Nonetheless, ClickFunnels additionally has their own powerful automation tool called Actionetics.
Although you could develop, timetable, as well as deliver e-mails just like other email advertising and marketing system, Actionetics is a lot a lot more.
I like Actionetics because it not just replaces your email advertising and marketing yet messenger marketing and SMS marketing software applications as well. This takes automation to an entire new level and aids you interact the best message to your customers, exactly when they need it. A video clip review of Actionetics will certainly be given additionally listed below.
A fantastic attribute within ClickFunnels is the capability to accumulate all the invoicing information from your consumers right on your sales page. Selling is made a lot easier when clients don’t have to leave your website.
ClickFunnels integrates with significant repayment entrances such as PayPal, Stripe, and also InfusionSoft, among others.
I’ll go into detail for each of these strategies listed below.
The basic strategy includes every one of the attributes you would need within ClickFunnels, however with limitations on the variety of funnels (20) and also pages (100) you could have in your account, in addition to how many visitors (20K) can see your pages each month.
You also do not receive sophisticated capability such as ClickFunnels very own e-mail advertising and marketing and also associate tracking devices.
This strategy includes all the bells as well as whistles of the standard plan, with no restrictions. It likewise has two additional products created by ClickFunnels called Actionetics (email advertising) and Knapsack (affiliate administration system).
In Knapsack – with the click of a mouse, you could add an associate program to any of your funnels. After that Knapsack will certainly track your clicks, sales, as well as just how much to pay your associate partners.
If there’s one concern I obtain usually, it’s “Which ClickFunnels Plan should I get”?
The difference between the two plans truly is the restrictions, and also Actionetics/Backpack. If you are a standard individual as well as don’t expect to make use of greater than 20 funnels in your account – the Criterion Plan ought to suffice.
However, if you intend to have an associate program or intend to keep your e-mail advertising within ClickFunnels as well as not use a third party software, the Etison Suite is for you.
You can constantly begin on the reduced strategy and upgrade if needed.
For any person that’s significant concerning their organisation, the ClickFunnels Funnel Hacks System is the bargain of the century.
The $997 Funnel Hacks System includes robust training programs packed with 6-month access to the ClickFunnels Etison Suite.
This is an extraordinary deal since outside of this program, 6-months of Etison Collection alone would certainly cost you $1782.
Not just are you conserving $785 however you’re obtaining a lots of trainings and also guides to assist you obtain the most out of ClickFunnels!
There is always support offered (whether real-time or not).
Exceptionally energetic Facebook Team Community.
Free 14-Day Trial – permits you to attempt it take the chance of free.
Support isn’t really constantly the fastest and may extract from 1 minute to 24 hours depending on the problem.
Many individuals ask how ClickFunnels compares with other touchdown page contractors such as Leadpages, Unbounce, and also Infusionsoft.
Essentially it’s not really a fair contrast due to the fact that each of these tools succeeds is one area or the various other.
The graph over provides an extensive evaluation – yet I’ll highlight several of the major comparisons below.
Prior to ClickFunnels, Leadpages was the large pet dog.
Leadpages is simply a lead capture software – nothing more. You could develop touchdown web pages, lead boxes, accumulate leads … that’s basically it. In addition, the Leadpages templates are likewise limited on personalization.
Basically, Leadpages is truly simply a touchdown page contractor, while ClickFunnels is concentrated around constructing highly incorporated funnels.
Infusionsoft is not a touchdown web page or sales page building contractor. It has several of that capability constructed it, yet that’s not just what it’s known for.
At it’s core, Infusionsoft is a CRM platform – one that allows you to manage your whole consumer database. ClickFunnels has this capability with Actionetics, yet it’s not virtually as progressed as Infusionsoft.
Infusionsoft is additionally extremely pricey and also forces every new consumer to pay $2000 for a mandatory kickstart coaching plan just to find out how you can utilize the complicated system (which is notoriously tough to utilize).
There are two major courses people go down as ClickFunnels users.
Those that choose to make use of the device for their service – in hopes of eventually attain both Comma Club (over $1M in revenue).
And also those that are interested in earning passive earnings as a ClickFunnels Affiliate as well as winning the Desire Vehicle Competition (where they pay $500/$1000 in the direction of your dream cars and truck if you get to 100/200 active monthly signups, respectively).
With a whopping 40% monthly persisting commission, ClickFunnels quickly has among the best associate programs of any platform out there.
That’s right – you make money an ongoing 40% compensation on every associate signup you make through the ClickFunnels Associate Program. Yet, what does that truly correspond to?
The basic plan is a $97/month investment as well as the Etison Collection strategy is a $297/month investment. therefore you make $38.80 per standard strategy and $118.80 per Etison Suite strategy … each and every month!
Typically, every 100 signups will certainly bring in $4000/month in affiliate commissions (basically depending on how many Etison Strategy individuals remain in there).
Visit this site for more information concerning becoming a ClickFunnels Associate.
ClickFunnels is by far the greatest system if you are wanting to quickly develop high converting sales funnels.
Due to the fact that it was developed from the ground up to be the best sales funnel home builder, it defeats every one of the competition in that regard.
If you’ve reviewed this far into my ClickFunnels Review, I suggest you see on your own with a Free 14-Day Test below. | 2019-04-21T11:03:34 | https://openerpbook.com/what-is-backpack-on-clickfunnels-see-what-all-the-talk-is-about/ |
Regardless of which holiday you’re celebrating, it’s always festive and fun to set up some dazzling display.
Halloween is over, and the holidays are fast approaching! It’s time to start considering how you’re going to decorate your yard for the occasion. Regardless of which holiday you’re celebrating, it’s always festive and fun to set up some dazzling display. It can be a family activity or a form of self-expression. Are you stuck thinking of cool, original ideas for your outdoor lighting project? Here are some DIY ideas for you!
You can hook all of your outdoor lights up to a timer to ensure they turn on and off at the appropriate times. Even if you’re not home when the sun sets, your home can still sparkle in the night. Timed light systems can also be used to create an awesome light show–there are some great Youtube videos that can show you how to do this!
It’s time consuming and frustrating to wrap a string of LED lights around each of your shrubs. If you’re looking for a quick and easy solution, you should invest in net lighting. At any holiday store or department store, you can probably find them for cheap around the holidays. They’re simply lights in an even net shape which you can drape over your shrubs. Problem solved!
It’s important to ensure that your walkway is well-lit during the holidays, as you’ll probably have plenty of visitors, from carolers to family. To keep your walkway welcoming, take advantage of all your shrubbery and foliage lining the path. If you lack the greenery, you can also look for cool pathway solutions at your local holiday store.
Don’t forget to prepare your deck and fence for the holidays with Mid Atlantic Deck & Fence! | 2019-04-20T14:21:48 | https://www.midatlanticdeckandfence.com/blog/amazing-diy-outdoor-holiday-light-ideas/ |
Diplomat Magazine is the new sponsor of Asociación Española de Profesionales en Holanda. It is a novel concept of diplomatic publications in Europe and the World. This subscription-free monthly-Online non-profit magazine. All the members of our association are already enjoying their diplomatic cultural-social programmes.
Diplomatic Magazine is one of the most important magazine of The Netherlands. It is the conception of top Dutch ICT-designer professionals and the volunteer action from international relations researchers, the academia, foreign affairs experts, local NGOs, selected by Dutch voluntary journalists, professional photographers. Also by Dutch lawyers and notaries, public servants, fine arts gurus, and the last but not least, the honorary and kindheartedly participation of chosen senior diplomats accredited to The Netherlands.
It is available in The Netherlands to Diplomats, Dutch Government officials and the public in general. Diplomat Magazine is unique, the first of its kind in Dutch diplomatic press history and the only official diplomatic publication in the Netherlands. You can join in their diplomatic gatherings, concerts, exhibits, their participation in festivals, also their anniversary celebrations and the last but not least, Diplomat Magazine’s Diplomat of the Year Awards Gala.
With the release of our new Media Partner, all members of the AEPH have the opportunity to attend exclusively to the last event organized by Diplomatic Magazine. The members could do the Zaeland-Middleburg and The Delta Works tour, which will be attended by a large number of national and great diplomatic figures with whom you could enjoy it, and follow the trip thanks to Mrs. Gonda Buursma tour guide.
All those members who wish attend the tour should contact: [email protected] in order to arrange it. | 2019-04-22T18:28:04 | https://www.profesionalesholanda.org/en/sponsors/103/ |
MeggieSoft Games is a small, long-established (since 1994), software games development company dedicated to the creation of two-handed card games for the Microsoft Windows environment. Our games are faithful implementations and adhere to rules documented in Hoyle's Rules Of Games, the Encyclopædia Britannica, and many other sources.
We strive to create the best quality software at shareware "try before you pay" prices. Our policy is not to charge for updates and upgrades - once you are a registered user of a game, you remain a registered user for all future versions of that game.
By offering a range of games sharing the same foundation user-interface, MeggieSoft Games users are able to enjoy most of the major two-player card games without the need to learn a new way of operation for each one.
Each game is played against an online opponent, or against the computer. The computer opponent can be selected to adopt any of six different skill levels. Full game score history information is maintained, including Hall Of Fame and League Table, for up to twelve named players - perhaps one named player for each member of your household.
Over time, we also incorporate rule variations suggested by users in order to provide the broadest possible range of play. We believe our games to be the most comprehensive available in terms of completeness of known rule variations.
A comprehensive help file and a printable user guide accompanies each game. This describes in depth how to play the game itself and how to get the most enjoyment from the MeggieSoft Games interface. In addition, all of the games feature walk-through tutorials, explanatory prompts, analytical aids, and hint capability. | 2019-04-25T04:32:26 | http://www.bufton.org/meggiesoft/aboutmsg.htm |
Are you trying to find Hospice services in Fairbury IL? There are numerous Hospice services in Fairbury, Illinois. Below are the closest Hospice offerings to Fairbury IL. | 2019-04-21T20:43:32 | http://www.abcd-caring.org/hospice-fairbury-il |
The curvature of the lugs is spot-on, although a strong downward angle isn’t necessary due to the slim build of the watch. Men39 Fake Watches For Sale Cheap Replica Watches, replica watches For Sale Online. If after a week you have not experienced withdrawal, you’re ready for that chronograph sans date. The rest of the name follows Omega’s convention: ‘Master’ was used for the professionally oriented watches, such as the Seamaster (diving tool) and the Railmaster (antimagnetic tool for engineers). But no matter: It was a Imitation Tag Heuer lovely weekend for a drive through the Swiss countryside with some fantastic watch-related discoveries at every turn! The automatic caliber UN-118 is entirely in-house. The main question remains simple: are Patek Philippe collectors going to adopt such a novelty Yes. The new Calibre 3235 is of course more than welcome and considering all the improvements it features, it finally brings Rolex into modern ages; the 3135 is an excellent and reliable movement but its conception was rather old. Same goes for the Tag Heuer replica leap year, which is extremely important when setting the watch but not as useful as an indication, and this why it is placed on the movement side here. However, with such shapes, do keep in mind that it will wear slightly larger than a round watch. In fact, bronze is not Imitation Tag Heuer stable and tends to age very quickly when exposed to water, acids, high temperatures or simply sweating. The movement of the hours along the minutes besides the 120 degree arc, is driven from the continuously rotating ring. The principle is simple: the first round takes place on the dedicated website, autaviacup. Movement: ML112 with automatic winding (based on the Tag Heuer Replica SW500); 46h power reserve – 28’800 vibrations ,25 jewels hours, minutes, small seconds, chronograph, date. | 2019-04-25T13:02:04 | https://www.wemyt.com/wp-includes/SimplePie/HTTP/reserve.html |
When you grab an over-the-counter pain reliever, the assumption is that it’s reasonably safe, but the line between a safe dose of acetaminophen and a toxic one is scarily narrow.
A new study, published in the Journal of Hepatology, found that acetaminophen is responsible for a shocking 46 percent of liver failure cases and 100,000 calls to Poison Control every year. What is going on with acetaminophen?
Why a prescription? Because of how easy it is to take too much, which results in serious liver damage.
I first learned about how unsafe acetaminophen can be from an episode of Adam Ruins Everything. The episode title is Adam Ruins Security, and he explains that part of the problem is that Tylenol isn’t the only medication containing acetaminophen.
Before you pop a Tylenol for your next headache, make sure you’re not already taking another medication with acetaminophen in it.
What is a safe dose of acetaminophen?
The National Library of Medicine says that acetaminophen is perfectly safe at low doses. The problem is that the difference between the recommended dose and a toxic dose of Tylenol is a little as two to three pills.
Tylenol recommends a maximum daily dose of 3,000mg, or six pills a day, spaced four hours apart. According to The National Library of Medicine, taking 4,000mg (that’s eight pills per day) for three to seven days is enough to begin damaging your liver. The good news is that if you stop taking the drug within this time period, your body will most likely bounce back.
Know Your Dose—a coalition of healthcare providers and consumer advocacy groups—says that taking more than 4,000mg in a day is considered an overdose and can damage your liver. That’s just three daily pills more than the recommended dose. Below is an infographic laying out some important acetaminophen safety facts. You can click the graphic below to view it larger.
The best way to protect yourself from acetaminophen overdose is to take as little as possible. If you have a headache, take one Tylenol instead of two, and see if that helps. Better yet, take a different pain reliever that has a better safety record, or try some natural pain relieving methods before popping a pill at all.
It’s also important to know what other medications you’re taking contain the drug. If you’re not sure, call your pharmacy. A pharmacist can tell you exactly what is in the medications you’re taking.
Tylenol & Advil: Which is better?
I don't use that. Thanks.
Read labels of OTC drugs and prescribed drugs.they tell you if there's acetaminophen and how muchis in them .No need to guess. | 2019-04-22T16:23:57 | https://www.care2.com/greenliving/this-over-the-counter-medication-is-not-as-safe-as-you-think.html |
Bailey McBride, a longtime professor of English and former administrator at Oklahoma Christian University, became interested in The Christian Chronicle when he started college. In 1979, when John Beckloff, pioneer missionary to Nigeria, bought the Chronicle and moved it to Oklahoma City, McBride became part of an advisory board and eventually began working for the paper under the direction of editor Howard Norton.
He taught at the college level for most of his adult life, specializing in 18th and 20th century British writers. He taught while serving as Vice President of Academic Affairs for Oklahoma Christian. His last major project before retiring from the university was directing and teaching in the Honors Program.
McBride and his wife, Joyce, were married for nearly 59 years. In 1966 they began worshiping with the Memorial Road Church of Christ in Oklahoma City, where Joyce McBride taught pre-K Bible classes for 45 years. Bailey McBride served as the church’s education director, as a deacon for missions and as an elder. He and Joyce raised three children in the church. They have 12 grandchildren (four by marriage) and two great-grandchildren. Joyce McBride died in April 2015.
In 2017 Bailey McBride married Linda Samples. He continues to teach Bible classes for the Memorial Road church and makes regular trips to Europe to encourage Christians there. His great passion is mentoring younger men and women as they seek to teach and to serve.
Panera and Psalms: Where do you find much-needed reflection? | 2019-04-20T03:01:14 | https://christianchronicle.org/author/bailey-mcbride/ |
Paul Signac, c. 1892-93 picture, right click and select "Save Picture As" from popup menu. Or, click "Set as background"
Paul Signac, c. 1892-93 wallpaper download from our Art collection. Feel free to share with family and friends! | 2019-04-20T22:41:51 | http://deskpicture.com/DPs/Art/WhiteTailPainting_5.html |
We’ve played two more sessions of Acts of Evil since I wrote about it a couple of weeks ago. I’m putting my playtest notes here in the blog in the interest of having the whole story in one place, and to give interested readers an idea of how one might go about writing hopefully useful playtest reports for a roleplaying game. I’m a bit behind on my playtest reporting due to all seven kinds of busyness, but luckily playtest reports get shorter when the campaign progresses and issues get addressed; otherwise I’d probably burst a blood vessel one of these days. | 2019-04-20T17:03:01 | https://isabout.wordpress.com/category/gaming/roleplaying/forge/acts-of-evil/ |
Currently 3 left in stock.
Continuing the success of Atom V2 and Atom V3, RotorX now brings you the Atom 4. Atom 4 retains the traditional Atom look while improving on previous Atom versions to provide a strong backbone for props and motors.
Included polycarbonate canopies come in random colors.
Atom 4 has had the milled section removed to increase frame strength. | 2019-04-19T05:13:32 | https://www.phaserfpv.com.au/products/rotorxatom4inchframekitrxatom4 |
While developing up in Baltimore, MD, R&B singer Paula Campbell was recognized to her friends as Sparkle, a nickname predicated on Irene Cara’s personality in the film from the same name. Exactly like Sparkle, Campbell was driven to be always a star no real matter what the road blocks. The music of Stevie Question, Teena Marie, and Sheena Easton motivated her to maintain her distance in the medication hustlers and various other negative affects infiltrating her community and concentrate on her abilities. Learning the liner records of every record she bought, Campbell gathered the names of each record label’s A&R rep and cold-called them seeking to get agreed upon. After winning skill shows and showing up in regional showcases, Campbell released the unbiased single “HOW EXACTLY DOES It Experience?,” which spent eight weeks near the top of regional train station WERQ’s playlist. Her debut recording, Who Got Following?, was individually released in 2004 and presented a cover edition of Lisa Lisa & Cult Jam’s “I Question If I Consider You House.” A yr later she authorized a cope with main label Sony. | 2019-04-20T11:21:49 | https://celebsnetworth.org/paula-campbell-net-worth/ |
To all our troops who are constantly sacrificing for our freedom we say Thank You!
Please download this Christmas EP with our compliments. We hope you feel appreciated, loved and remembered this time of year. | 2019-04-20T08:44:26 | https://willypete.com/album/14030/a-willy-pete-christmas-vol1 |
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Home Food & Beverage Cooking Baking Steel Coupons updated on 25 April, 2019. | 2019-04-25T08:34:45 | http://www.couponsoar.com/baking-steel-coupon-16859.html |
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We enjoyed attending the Aylsham ESPO which was an exhibition of local organisations in Aylsham who were promoting themselves. We had tasty samples for people to try and talked to lots of lovely people. We look forward to seeing some new faces in the Country Market on a Friday morning. | 2019-04-24T10:55:09 | http://aylshamcountrymarket.simplesite.com/427950162/4516674/posting/text |
HomeEnvironment/ConservationWild Ideas: Is that a rufous hummingbird at your feeder?
Wild Ideas: Is that a rufous hummingbird at your feeder?
While at my brothers’ in Southeast Alaska this fall, we were watching rufous hummingbirds (Selasphorus rufus) at his feeders, swapping stories about his hummers and mine here in Virginia, the ruby-throated (Archiochus colubris). I bemoaned the fact that each of us only got to see one species of hummer where we lived.
I found out that the range of the rufous had expanded into Virginia in the 1980s and now extends all the way up the East Coast into the Canadian Maritimes, according to Bruce Peterjohn, chief of the Banding Laboratory of the the U.S. Geological Survey’s Patuxent Wildlife Research Center. Palmer had contacted Peterjohn to come confirm the identity of the hummer at her feeder, which he planned to do after this column went to press.
According to Hummingbirds.net, the rufous is “the most widely distributed hummingbird in North America” and has even been spotted in Siberia. I found a map at Learners.org that contained the number of sightings along the East Coast as the year progressed.
So why hadn’t I heard about this? The number of rufous in Virginia has “soared” since the late 1980s, according to the Virginia Society of Ornithology’s 2007 “Virginia’s Birdlife: An Annotated Checklist,” but that means from one in 1987 to 13 in 2001. Although its populations continue to increase, the book describes the species as a “rare but increasingly fall transient and winter visitor” throughout Virginia.
I also did a quick poll of some birders I know in the Piedmont and got several reports of the rufous showing up at feeders this year or in past years and one being recorded in a Central Loudoun Christmas bird count.
An individual Selasphorus rufus can also fly an incredible distance annually. The “Checklist” cites an immature female that was captured and banded in Chesterfield, Va. (a few miles south of Richmond) on Nov. 29, 2001. This bird was recaptured near Red Lodge, Mont., in August 2002, and then recaptured again at the same feeder in Chesterfield on Dec. 1, 2002. That’s almost 6,000 miles of traveling in a year – maybe more, since migration of hummingbirds tend to be “U” shaped, dipping to the south.
The expansion in its range is not the only interesting thing about the rufous. Measuring in at a whopping maximum 3.5 inches and 0.12 ounces for the females (who are larger than the males), this tiny bird is often described as being “tough,” “feisty” and agile enough to outmaneuver other hummers at feeders.
Females and especially the young are hard to identify at any time of the year. They can be confused with ruby-throated, and for another bird, the Allen’s hummingbird (Selaphorus sasin). The Allen’s shares the rufous’ breeding ground in Mexico and has also expanded its range into Virginia.
The females and young are so similar between the rufous and Allen’s, says Peterjohn, that he has to use a caliper to measure the outer tail feathers, which are millimeters wider on the rufous, to tell the two species apart. The ratio of rufous to Allen’s in Virginia is about 15:1, according to Peterjohn, so sightings are more likely to be of the former.
While it’s true that hummers generally prefer nectar when available, when that’s not available, they rely on insects for food, especially to feed their young. Insects will also appear throughout the fall and winter here whenever temperatures get above 40 degrees.
What about when it’s colder? That’s where we humans come in. The rufous can overwinter here only if we feed them. The increase in the number of people feeding them is why their range has expanded, says Peterjohn.
Just a follow-up on my column: a black-chinned hummingbird was just sighted at a nectar feeder in Pulaski County, Virginia. Fill it and they will come! | 2019-04-21T20:05:13 | https://rappnews.com/2010/11/11/wild-ideas-is-that-a-rufous-hummingbird-at-your-feeder/ |
The Multiplayer Starter Pack gives you access to Public Ranked Multiplayer matches and features including Weapon Paint Shop, Gunsmith, Arena, Freerun, Theater, and the Black Market. "
This version of the game does not contain Black Ops III's single player campaign mode, nor its Zombie modes. Players are capped to level 55 and cannot play in custom multiplayer games. It also doesn't support the upcoming mod tools for Black Ops III. If a person wants to purchase the full version of the game after checking out the Starter Pack, the $14.99 will be deducted from the full $59.99 price.
Frontier Developments has also released Elite Dangerous: Arena on Steam for $7.49. Unlike the Call of Duty: Black Ops III Starter Pack, Elite Dangerous: Arena will be available to purchase and download indefinitely. It includes all of the space fighter-based multiplayer content of Elite: Dangerous but does not contain the main game's exploration modes. The new game also allows players to enter the Close Quarter Combat Championships tournament and its $100,00 prize pool. Again, players who decide to purchase the main Elite: Dangerous game for $29.99 will get a discount equal to the price of Elite Dangerous: Arena.
There's no word yet on if Call of Duty: Black Ops III Starter Pack or Elite Dangerous: Arena will eventually be released for their Xbox One counterparts. | 2019-04-23T02:29:56 | https://www.windowscentral.com/call-duty-black-ops-iii-and-elite-dangerous-both-get-stand-alone-multiplayer-pc-games |
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After we install the certificate, you’ll need to publish your site. The SSL is not fully installed until after the site is published. | 2019-04-19T14:13:50 | https://www.iiihost.com/quick-shopping-cart/ |
IXL's fourth-level skills will be aligned to the Curriculum for Excellence Benchmarks soon! Until then, you can view a complete list of fourth-level objectives below.
Objectives are in black and IXL English skills are in dark green. Hold your mouse over the name of a skill to view a sample question. Click on the name of a skill to practise that skill.
R.1.A I regularly select and read texts for enjoyment and interest, and I can express how well they meet my needs and expectations and give reasons, with evidence, for my personal response.
R.1.B I can independently identify sources to develop the range of my reading.
R.1.1 Selects regularly and independently, texts for enjoyment and interest or relevant sources to inform thinking.
R.1.2 Gives a personal response to spoken texts or explains how well a spoken text or source meets needs and expectations, justifying opinion with relevant reference to the text.
R.2.A Through developing my knowledge of context clues, punctuation, grammar and layout, I can read unfamiliar texts with increasing fluency, understanding and expression.
R.2.B Before and as I read, I can apply strategies and use resources independently to help me read a wide variety of texts and/or find the information I need.
R.2.1 Reads with fluency, understanding and expression across a wide range of texts.
R.2.2 Applies knowledge of language such as word roots, grammar, punctuation, tone, sentence and text structures to read texts with understanding.
R.2.3 Applies a range of strategies to engage with and interrogate texts, for example, skimming, scanning, predicting, clarifying, summarising, analysing and annotating.
R.3.A Using what I know about the features of different types of texts, I can find, select, sort, summarise, link and use information from different sources.
R.3.B I can make notes and organise them to develop my thinking, help retain and recall information, explore issues and create new texts, using my own words as appropriate.
R.3.1 Finds, selects and sorts essential information from a variety of sources for a range of purposes.
R.3.2 Summarises key information, from more than one source, using own words.
R.3.3 Uses own words to make and organise notes, synthesising key information from different sources.
R.3.4 Uses notes to create new texts that show an understanding of the topic or issue, synthesising information from different sources.
R.4.B To show my understanding, I can give detailed, evaluative comments, with evidence, on the content and form of short and extended texts, and respond to different kinds of questions and other types of close reading tasks.
R.4.C To help me develop an informed view, I can recognise persuasion and bias, identify some of the techniques used to influence my opinion, and assess the reliability of information and credibility and value of my sources.
R.4.D.c identify and make a personal evaluation of the effect of aspects of the writer's style and other features appropriate to genre using some relevant evidence and terminology.
R.4.1 States clearly the purpose, audience and main ideas of a range of texts with appropriate justification.
R.4.2 Makes accurate inferences with appropriate justification.
R.4.3 Compares and contrasts the content, style and language of different texts with supporting detail.
R.4.4 Responds in detail to a range of close reading questions to show understanding of texts and knowledge and understanding of language.
R.4.5 Makes evaluative comments about the effect of features of language, for example, word choice, sentence structure, punctuation, grammar and/or imagery.
R.4.6 Identifies the use of bias and persuasion and comments appropriately on some of the techniques used, for example, word choice, emotive language, repetition, rhetorical questions, use of statistics and/or hyperbole.
R.4.7 Makes evaluative comments about relevance, reliability and credibility of sources, with appropriate justification.
R.4.8 Makes evaluative comments about the effectiveness of structure, characterisation and/or setting with relevant reference to the text.
R.4.9 Shows understanding of how the writer's theme is developed and recognises how it relates to own or others' experiences/the writer's purpose/the central concerns of the text.
R.4.10 Identifies and makes evaluative comments on aspects of the writer's style, use of language and other features appropriate to genre with detailed reference to the text and appropriate terminology.
W.1.A I enjoy creating texts of my choice and I am developing my own style. I can regularly select subject, purpose, format and resources to suit the needs of my audience.
W.1.1 Writes for a range of purposes and audiences. Makes well-considered choices about genre, form, structure and style to enhance communication and meet the needs of the audience.
W.2.A I can use a range of strategies and resources independently and ensure that my spelling, including specialist vocabulary, is accurate.
W.2.B As appropriate to my purpose and type of text, I can punctuate and structure different types of sentences with sufficient accuracy, and arrange these to make meaning clear, showing straightforward relationships between paragraphs.
W.2.C Throughout the writing process, I can review and edit my writing independently to ensure that it meets its purpose and communicates meaning clearly at first reading.
W.2.D I can justify my choice and use of layout and presentation in terms of the intended impact on my reader.
W.2.1 Applies a range of strategies and resources to ensure accuracy of spelling including unfamiliar or specialist vocabulary.
W.2.2 Uses a variety of punctuation, including more complex punctuation, to convey meaning and enhance writing, for example, inverted commas, colons, semi-colons, parentheses, dashes and ellipses. Punctuation is varied and accurate.
W.2.3 Writes grammatically accurate sentences.
W.2.4 Uses a variety of sentence structures to clarify meaning and enhance writing, for example, simple and complex sentences, lists, repetition and/or minor sentences. | 2019-04-23T04:46:56 | https://uk.ixl.com/standards/scotland/ela/fourth-level?documentId=2020001402&subsetId=-1 |
The interim solution seems to be upgrading existing facilities to increase bed numbers or building new centres.
However, the real key to a sustainable corrections system is to lower prisoner numbers whilst preserving community safety. There are increasing calls to overhaul the entire justice system and to look at holistic approaches to ensuring that fewer people end up in our prison system.
It is no surprise that in the current environment, the Queensland Government has announced that the Queensland Productivity Commission will undertake an inquiry to determine how best to reduce imprisonment and recidivism.
Below, we discuss three ideas to achieve reductions in recidivism.
Recently, there has been an increasing focus on outcomes-based contracting by governments, to ensure that service providers are incentivised to achieve specified outcomes – for example, a targeted reduction in recidivism.
Governments are structuring payment provisions with some or all of the service provider’s fee dependent on the achievement of the outcomes. The benefit of this model is that governments are able to focus on the policy outcome while handing the method of delivery to the private sector. The extent to which the service provider fails to achieve the outcome, the service is cheaper for the State.
This model is most likely to be effective in circumstances where the outcome can be clearly and objectively defined and measured, the service provider has sufficient control of the outcome and where the rewards and remedies are clear.
In a prisons services contract it may be appropriate to require the service provider to meet certain recidivism targets if the service provider is responsible for overall program delivery for a significant period of a person’s incarceration. In contrast, service providers to high risk individuals with complex needs are unlikely to be in a position to agree to a performance-based regime when so many factors about an outcome (such as reoffending) are beyond the service provider’s control and rely on other providers of service delivery (for example, health, housing and other support services).
Circumstances that arise once a person is released from prison, such as employment and housing, are indicators of whether a former detainee will return to prison.
For a material reduction in recidivism rates, long-term management mechanisms (when the person is no longer being provided services in the prison environment) need to be considered.
Service provision in the corrections context does not occur in a vacuum. All service environments are constrained by the physical environment.
Reducing recidivism should be considered at the design and construction stages of any prison project.
Nordic prisons are considered to be the gold standard for corrections services, measured by their low levels of recidivism. Among other things, this is because prisons are designed with a strong rehabilitative focus, making the space, comfort and privacy of inmates a priority, without sacrificing security. Prison spaces cleverly use colour and art to engender positive psychological effects on prisoners.
A Nordic-style solution isn’t the answer for every jurisdiction for cultural, political and financial reasons. However, while Australia invests in new facilities and expansions to facilities, it should look for all opportunities maximise reduction recidivism through the built structure.
The issues facing the corrections sector are not unique to that sector. Many other sectors, including the mental health system, are facing the same challenges – managing institutional care, transition and reintegration.
Borrowing insights and knowledge from other disciplines could open doors for innovative approaches to service provision in prisons.
We know that community re-integration is crucial to reducing recidivism, and the statistics show that the vast majority of people returning to prison are unemployed at the time of re-entry to the justice system.
Singapore’s ‘Yellow Ribbon Project’ is a shining example of how better community perceptions of former detainees can have a positive impact on return to prison rates.The program encourages employers to register to employ former detainees. Singapore has seen significant benefits in the reduction in recidivism.
the State supplements the released inmate’s income with an amount being conditional on the released inmate not returning to prison within a specified time.
The pilot program could be government funded and driven – the government would use the potential savings which it would have expended on the inmates if they returned to prison.
An alternative delivery mechanism, such as a social benefit bond arrangement, could also be investigated.
The corrections industry – especially youth detention – continues to occupy the spotlight, and the public have their eye on public funds spent.
Different contracting methods, whole-of-supply chain consultation, and expertise and cultural change beyond the prison all offer radical opportunities to derive value in this important and politically-charged space. | 2019-04-26T10:02:15 | https://www.lexology.com/library/detail.aspx?g=1960a9eb-3e31-416e-a791-f3615de140de |
codeCoverage is a Dyninst-based code coverage tool that provides both function and basic block level output.
Uses the Dyninst binary rewriter, which allows code coverage instrumentation to be inserted once and used across different input sets.
Includes options to limit code coverage data to just functions as well as options to sort the code coverage output.
Dependent shared libraries can be instrumented in addition to the application binary. | 2019-04-21T18:19:29 | http://www.paradyn.org/html/tools/codecoverage.html |
Without friends like you, I might not still be here. Thanks so much for the encouragement.
Time has passed quickly, leaving me wondering exactly what I have accomplished. I had such grand plans, but the whole business takes work! Maybe my new year’s resolution should be to work a little harder and more often.
Wow, it’s hard to believe it’s been five years. Thank you for all your care and giving of yourself and love for those of us who read your efforts and LABOR of love. So many scriptures come to mind when I think of your persistence and giving of yourself to what sometimes may seem like casting your bread upon the water. I pray you will see it again after many days.
She hath done what she could!
Heb 6:10-12 For God is not unrighteous to forget your work and labor of love, which ye have showed toward his name, in that ye have ministered to the saints and do minister. And we desire that every one of you do show the same diligence to the full assurance of hope until the end: that ye be not slothful, but followers of them who through faith and patience inherit the promises. | 2019-04-26T10:29:15 | https://helpmeettohim.org/2018/01/15/achievement/ |
To rehabilitate customers in arrears in the pre lock-up categories and appropriately action allocated accounts via the various collections mediums with the aim of regularising accounts in order to minimize the forward roll into more serious delinquent categories.
To effectively work all NPL (lock-up) and Written off accounts to contribute towards increasing the collection/recovery rate and diligently update control registers, outsourced files and supply of demographic information when required.
Timeous and adequate actioning of all accounts in terms of the rehabilitation/recoveries strategy.
Ensure compliance with statutory, regulatory and supervisory requirements, to protect the reputation of the Group and to avoid legal action/sanction in respect of regulatory and operational compliance matters.
To institute collection/recovery action on all NPL/written off accounts as and when required.
To assist in ensuring that present and future departmental objectives are achieved by maximising the recovery on written off accounts.
Adhere to Bank policies and procedures.
Maintain and enhance customer service.
Timeously refer all insurance claims, retrenchments, disabilities, deceased, insolvencies, tracing matters and recommended repossession action to the Team Leader.
Sound communication and negotiation skills.
Have a supportive, solution seeking approach.
Works as part of a team and builds relationships.
Well-spoken and sound telephone techniques.
Must be able to work under pressure and handle large volumes of accounts.
Demonstrates sound judgement and decision making abilities.
Continually bears customer focused solutions in mind.
2-years or more general customer debt management exposure.
Interested and qualified candidates should send their CV’s to: [email protected] The Subject of the mail should be “Rehabilitations and Recoveries Officer”.
Application Deadline 11th November, 2016. | 2019-04-23T08:21:13 | http://joblanda.com/graduate-rehabilitation-recoveries-officers-recruitment-financial-institution/ |
Chinese New Year is a fantastic time of the year. It’s full of colour, excitement and tradition. It is the time to eat, celebrate, cleanse your house, exchange gifts and watch the fireworks.
But for the shipping industry it can be an extremely difficult time. With most suppliers, customs authorities and shipping lines closing for the holiday, now is the time to start getting prepared for Chinese New Year 2014.
This holiday falls on the 31st January 2014 and heralds in the Year of the Horse.
Be prepared early to avoid any unnecessary delays.
I have 10 (ten) 40ft containers.
Do you know of any business that would hire them or lease them out. | 2019-04-25T13:45:16 | http://eescair.com/?p=681 |
Here at House Inspector Crew, we are here to satisfy your standards when it comes to House Inspector in Shook, MO. Our crew of highly skilled experts can provide the expertise that you need with the most sophisticated technologies in the industry. We will apply high standard supplies and cash conserving practices to ensure that you will get the best solutions for the best price. Contact us today by dialing 888-506-4448 to get going.
Here at House Inspector Crew, we understand that you need to keep in budget and lower your expenses wherever it is possible to. Still, saving money should not indicate that you give up superior quality on House Inspector in Shook, MO. We provide the best quality while still helping you save money. Our intention is to make sure that you acquire the best quality materials and a end result which endures throughout the years. As an example, we are thorough to avoid pricey errors, work efficiently to save hours, and make sure that you get the most effective bargains on supplies and labor. Call up House Inspector Crew when you need the best services at the lowest price. Call 888-506-4448 to talk with our customer service agents, today.
You will need to be informed concerning House Inspector in Shook, MO. You shouldn't enter into it without knowing it properly, and you need to understand what to anticipate. We will take the unexpected surprises from the equation by providing precise and thorough information. Start by dialing 888-506-4448 to go over your venture. We're going to talk about your concerns whenever you call and help you get arranged with a meeting. Our crew can arrive at the appointed time with the appropriate resources, and can work together with you all through the undertaking.
There are a lot of good reasons to pick House Inspector Crew for House Inspector in Shook, MO. We are the best option whenever you need the best cash saving options, the highest quality products, and the highest rank of customer service. We fully understand your expectations and intentions, and we're available to assist you with our expertise. Whenever you need House Inspector in Shook, choose House Inspector Crew by dialing 888-506-4448, and we are going to be more than pleased to help. | 2019-04-20T19:01:27 | http://www.houseinspectorcrew.com/mo/house-inspector-in-shook/ |
The number of diplomats and relatives with diplomatic status arrested by West Midlands Police in 2014, 2015, and 2016 so far. Please specify what each person was arrested for, and what country they represented.
Our data are not organised in such a way as to allow us to provide this information. West Midlands Police have no specific markers to identify people with diplomatic immunity, therefore we would need to undertake a manual search of all custody records to locate this information. | 2019-04-23T14:54:53 | http://foi.west-midlands.police.uk/diplomatic-status-arrests-3919_16/ |
Autobahn Toolbar by Deutsche Bank - Should I Remove It?
Should I remove Autobahn Toolbar?
Autobahn Toolbar is a software program developed by Deutsche Bank. Relative to the overall usage of those who have this installed, most are running it on Windows 7 (SP1). While about 71% of users of Autobahn Toolbar come from the United States, it is also popular in United Kingdom.
Uninstaller: "C:\Program Files\Autobahn Toolbar\Uninstall_Autobahn Toolbar\Uninstall Autobahn Toolbar.exe"
How do I remove Autobahn Toolbar?
Quickly and completely remove Autobahn Toolbar from your computer by downloading "Should I Remove It?", its 100% FREE and installs in seconds (click the button below).
Or, you can uninstall Autobahn Toolbar from your computer by using the Add/Remove Program feature in the Window's Control Panel.
Follow the prompts. A progress bar shows you how long it will take to remove Autobahn Toolbar. | 2019-04-20T02:55:17 | https://www.shouldiremoveit.com/Autobahn-Toolbar-139191-program.aspx |
Come and be pampered for a Romantic Getaway Weekend. Stay in unique Adirondack lodging from ornate Victorian Saratoga Springs inns to secluded rustic country cottages in Lake Placid. Savor gourmet breakfasts at one of our bed & breakfasts. | 2019-04-26T11:48:37 | https://ticonderoga360.com/business/adirondack-bed-breakfast-association/ |
*3: have extra lining of mesh with five protection pockets. *7: have 8'' inch conection Zip for Pant attached. This Jacket is a perfect for the motorcycle riding.
We have a strong QC team and their professional experienced hard-working can guarantee the high quality and delivery time. 4.Competitive price :We are manufacture and we can purchase the material ourselves to lower the cost. 6.Any requirement, contact us without delay.
Custom Designs with Patches & Embrodiery: We can customize Leather jackets with your logos, names, patches and numbers, We also offer great deals on team Leather jackets, school Leather jackets and for football teams. Other options are Neck Label, hang Tags , Company Label , Care Labels etc. Production view: For Further Details: For more products informations / prices/ delive ry time/ shipping charges etc.
Alibaba.com offers 3,390 mens cordura jacket products. About 67% of these are motorcycle & auto racing wear, 22% are men's jackets & coats.
A wide variety of mens cordura jacket options are available to you, such as anti-uv, breathable, and plus size. You can also choose from polyester / cotton, 100% polyester, and polyester / nylon. As well as from jackets, shirts & tops. And whether mens cordura jacket is paid samples, or free samples.
There are 3,206 mens cordura jacket suppliers, mainly located in Asia. The top supplying countries are Pakistan, China (Mainland), and United States, which supply 90%, 4%, and 4% of mens cordura jacket respectively.
Mens cordura jacket products are most popular in North America, Western Europe, and Eastern Europe.
You can ensure product safety by selecting from certified suppliers, including 135 with ISO9001, 110 with Other, and 95 with ISO14001 certification. | 2019-04-19T07:32:38 | https://www.alibaba.com/showroom/mens-cordura-jacket.html |
Throughout 2011, Wall Street has been a household word. With the economy still in shambles, seemingly at the hands of fast and loose stock market trading, there are many opinions about the vaunted Manhattan financial center.
For many people, Wall Street is symbolic of unchecked greed and excess at the expense of innocent people. Others see the country's economic woes as symptomatic only of people's inability to live within their means. For them, Wall Street remains symbolic of all that is good about America's capitalistic roots.
Fortunately, Hollywood has something for everyone in this recession no matter whether you are a Wall Street cheerleader or hater. These movies have chronicled evolutionary changes on Wall Street through modern years with mesmerizing clarity in many cases. We're not talking about Tim Syke's penny stocks, these movies are about the titans of Wall Street. The characters in these movies have been indelibly seared into the American consciousness; woven into popular culture like golden strands.
We know you 're recession-weary, and looking for a diversion if even for just a couple of hours. For your viewing pleasure, we've compiled some of Hollywood's greatest attempts to make sense of Wall Street culture.
Starring Michael Douglas as the unforgettable Gordan Gekko. An Oliver Stone classic, from 1987, that depicts Wall Street's denizens in all the greedy glory.
Starring Eddie Murphy and Dan Akroyd when they were still funny. This John Landis comedy, from 1983, helped launch both stars careers and tells a hysterical tale of the rise and fall of the Wall Street elite.
Enron: The Smartest Guys in the Room This 2005 documentary isn't exactly typical Hollywood fare, but it does pull the curtain back for a look at the rise and demise of a company that has come to symbolize heartless greed.
The1990 film adaptation of Tom Wolf's classic book, starring Tom Hanks, doesn't exactly set its laser focus on Wall Street, but it does take an unflinching look at upper class Manhattan's estrangement from the rest of society.
Christian Bale plays Wall Street trader Patrick Bateman who is sinking into complete psychosis in this 2000 tale of murder and mayhem. Prepare to have your own sanity shaken with this one.
While this list doesn't include every movie ever made about New York's money mecca and it doesn't even touch on similar themes that play out in other locales, it does represent a diverse selection of Hollywood's varied representations of Wall Street culture. | 2019-04-22T11:17:56 | https://www.loupdargent.info/2011/12/wall-street-at-movies.html |
Delonte Maurice West was born on 26 July 1983, in Washington, D.C., US, of African- American and Native-American descent. Delonte is a professional basketball player, best known to have played for various National Basketball Association (NBA) teams such as the Boston Celtics, Cleveland Cavaliers, and Dallas Mavericks. He also played college basketball at Saint Joseph’s University, and all of his efforts have helped put his net worth to where it is today.
How rich is Delonte West? As of mid-2016, sources estimate a net worth that is at $100,000, mostly accumulated through a career in basketball. Throughout his career he was offered contracts that helped raise his wealth, however, his net worth is lower than most players and it may be due to the fact that he has had a rather controversial career. Time will tell if his wealth will increase.
Delonte started to become known for his basketball skills while attending Eleanor Roosevelt High School. He helped the school’s team reach the Maryland 4A championship, however, despite a good performance, the Raiders lost but West was still given honors and awards. After high school, he went to Saint Joseph’s University, where he played with Jameer Nelson. West and helped the team to a 27-0 record in the season and earn them an Elite Eight NCAA Tournament appearance.
After his junior year at Saint Joseph’s, West left to join the 2004 NBA Draft, and was selected as the 24th overall pick by the Boston Celtics. His rookie year was filled with struggles as he fought injuries, and was switched to the point guard position. The following year he became a starter and performed better. In 2006, he was again put to the shooting guard spot, but had difficulty and was switched back to point guard. During this year, he would get great performances including a career high 31 points and a buzzer-beating winning basket against the Charlotte Bobcats.
After the 2006 to 2007 season, with Rajon Rondo getting the starting position on the team, he was traded to the Seattle Supersonics, and the following year, he was traded to the Cleveland Cavaliers. He played well with the Cavaliers, highlighted by a 20 point performance against the Boston Celtics and a season high 11 assists against the Philadelphia 76ers. He was also a big help during the Cavaliers’ play-off run when they played the Washington Wizards.
In 2008, he signed a three-year $12.7 million extension which boosted his net worth significantly. He was also switched back to the shooting guard position to make room for Mo Williams. He would showcase his skills throughout the next season, helping the team get a franchise best 66 wins. He also helped the team during the play-offs, becoming a role player for a line-up that included LeBron James. In the 2009 to 2010 season, West’s averages started to decline, and he was soon traded to the Minnesota Timberwolves, but was soon waived. In 2010, he signed a one year contract with the Boston Celtics as Rondo’s backup point guard. However, he was suspended for the first 10 games of the season due to criminal charges. The following year he signed with the Dallas Mavericks, but was again suspended in 2012 due to internal arguments, and was subsequently waived by the team.
In the following years, Delonte would become part of the NBA D-League, playing with the Texas Legends. After a year, he moved to China to play with Fujian Xunxing and then the Shanghai Sharks. He then played with the Venezuelan team Guaros de Lara before returning to the Texas Legends.
For his personal life, it is known that West was diagnosed with bipolar disorder which may have resulted from the stress of the NBA lifestyle. He was arrested in 2009 because it was discovered that he was carrying multiple firearms while riding a motorcycle. He was also rumoured to have had a relationship with LeBron James’ mother, and this apparently effected his reputation.
5 24th overall pick by the Boston Celtics in the 2004 NBA draft out of St. Joseph's. | 2019-04-22T18:25:36 | https://networthpost.org/delonte-west-net-worth/ |
" Working at it's best to get all together "
Alumni Association named "Shri Tulja Bhavani College of Engineering Past Students Munch" is established on 10/11/2003,vide Reg.No. MAH/343/03. Our institute is celebrated the year 2007-2008 as Silver Jubliee year. Up till now more than 3500 students have completed their degree education from our College. Most of them working at very important position in Govt. and Private sector. Near about 300 alumni's are working in various countries accross the globe. Association plays common platform for all alumni's. We have organized two alumni meets in the year 2004 & 2005. All past students are supporting in various activities & development of College. | 2019-04-24T10:35:56 | http://stbcet.org.in/alumni.html |
Blinds can be used in any room of the house - they are a great way to transform a room with better sun protection, blackout or just a splash of colour.With hundreds of blinds available, our partners even offer next day delivery to G13. While our partners can offer a number of products directly 'off the shelf' they can also supply many solutions made to your exact measurements.
If you are buying made to measure blinds in G13 click on one of the images above. And if you don't see the type of product you need, then just click on the closest to find your way to the blinds that are exactly right for you in G13.
Blinds can brighten a room with colour, or they can darken a room if you prefer blackout. Kitchens, bathrooms, lofts and offices have long been the home for blinds, but these days more and more people are fitting them in their living room. Velux blinds are stylish and high quality . Many types of blind are much easier to clean than curtains as they can be wiped with a damp cloth, but it is very important that you check the manufacturer's guidelines as this will not be true of all.
Whether your venetian blinds are metal, wood, or even plastic, we really suggest you clean them every week with a vacuum brush attachment to ensure they stay as clean as possible. If you shut the slats completely you will be able to get them the cleanest. Of course if there have been mucky fingers, that will take a damp sponge to fix and then wipe them dry. Also, always check the guidelines from the manufacturer. Our partners can offer most of the window solutions available on the market, and deliver them direct to your door in G13.
This site is for blinds in G13. We offer a wide variety of wooden blinds, vertical blinds, roller blinds, venetian blinds, blackout blinds, panel blinds, velux blinds, roman blinds, and all can be made to measure for G13. | 2019-04-21T02:29:12 | https://blinds2blinds.co.uk/G13.html |
The new Denon DN-F20R ($1,299) is the company’s first portable IC recorder. Weighing just over two pounds, the DN-F20R records on up to two IC memory cards, eliminating moving parts and enhancing the unit’s reliability. The IC cards comply with international standards for the CompactFlash card and support a memory capacity of up to 192 MB. Memory cards are all 16-bit FAT formatted, enabling them to be read and written to by a PC equipped with a USB-type CompactFlash adapter or an ATA adapter for a laptop. Audio may be recorded in a choice of MPEG2 Layer 2, MPEG1 Layer 2, or Linear PCM (Wave) file formats, in either stereo or mono modes. Sound quality is also selectable in recording bit rates of 16 to 768 kbps per channel. Input complement includes two XLR mike jacks and two RCA line inputs, as well as a parallel remote mini-jack input terminal for external control. Outputs include two RCA line outs and a ¼-inch headphone jack. (973) 396-0810, www.del.denon.com.
Antares Audio Technologies presents their new AMM-1 Microphone Modeler. The AMM-1 is a studio DSP processor that allows any reasonably full-range microphone to sound like virtually any other microphone. Using their patented Spectral Shaping Tool (SST) technology, Antares engineers have created precise digital models of a wide variety of microphones, from historical classics to modern exotics, as well as a selection of industry-standard workhorses. The user simply tells the AMM-1 what microphone they are actually using and what mic they would like it to sound like. The AMM-1 then references the stored models of both the source and target mics and processes the input to create the sound of the desired mic. The AMM-1 can also be used during mixdown to effectively change the mic on an already recorded track. $999. (888) 332-2636, www.antares-systems.com.
Lexicon recently unveiled their new 960L Multi-channel Digital Effects System. The 960L is Lexicon’s next generation multi-channel digital effects system designed for the high-end professional audio, broadcast, film, live sound and post-production markets. Like the legendary 480L introduced over a decade ago, the new 960L will be Lexicon’s expandable technology platform for years to come. The 960L Multi-channel Digital Effects System is comprised of the 960L CPU (24-bit/96kHz, 4U high rack-mount effects system) and an all-new Lexicon Alphanumeric Remote Controller (LARC2™). Designed from the outset to support multi-channel audio, the 960L is a powerful multi-channel system whose feature set includes a host of surround and stereo reverb algorithms. The new 960L employs Lexicon’s proprietary 3DPM Perceptual Modeling™, which provides superb reverberation quality with the ability to create completely realistic spaces as well as hyperspaces (spaces that are perceptually better than any real-world spaces). Processing is handled by Lexicon’s propriety Lexichip ™ (4 per DSP card). In future updates, the 960L will support multiple DSP cards which can each support up to four stereo reverbs or two multi-channel surround machine(s) at 44.1 or 48kHz., or two stereo reverbs at 96kHz. Eight balanced inputs and outputs and 4 pairs of AES/EBU digital inputs and outputs are standard. The 960L has external word clock in/out/loop, MIDI In/Out/Thru, a 3.5" floppy drive for saving programs and system configuration and a CD ROM drive for software upgrades. The system is completely hardware/software upgradeable. The 960L contains hundreds of factory programs, including such industry standards as Halls, Chambers, Rooms, Plates, Stage+Hall, Stage+Chamber, Ambience, Wild Spaces, and Post. There are provisions for an additional 500 user-definable programs. 781/280-0300, fax 781/280 0490, www.lexicon.com.
The Swissonic USB Studio ($699) is the perfect solution for every home recording environment. It provides inputs and outputs for most of the equipment to be used in a typical home setup like two microphones (phantom powered), two HI Z instruments, four stereo line inputs, tape input (with switchable phono preamp!), S/PDIF input and output (optical and coaxial), tape output, monitor output and headphone output. Each input’s and output’s volume can be adjusted individually. The built in USB interface connects the USB Studio with your favorite computer (Windows 98, MacOS 9) and software (all standard audio applications). Each input source can be enabled for recording. The stereo mix is routed to and from the computer via the USB. There’s no need for a sound card. www.swissonic.com.
MediaFORM has added four new CD-R duplication solutions to its product line. The CD-3701 provides an efficient automated method to replicate a single CD-R. The CD-3703 simultaneously copies up to three CDs without any intervention and includes a spindle that holds up to 125 CDs. The CD-3706’s relay mode allows continuous, fully automatic duplication of up to six masters at the same time. The automatic stand-alone unit can access CD images stored on a local hard drive. It is compatible with MiniDiscs and CD business cards. MediaFORM’s fourth new product is a flexible, network-enabled print station that accommodates both thermal and inkjet printing needs up to 1200 dpi. The AP1301i-t enables high-resolution printing on 300 CDs per run, without the need for user intervention. 610-458-9200, www.mediaform.com.
SpotTaxi.com announced a major extension of its service. Next-day spot delivery is now available to every commercial radio station in the U.S. for the same price as its guaranteed, two-hour Internet delivery service. Effective immediately, any station not registered with SpotTaxi.com’s online delivery service will receive spots on compact disc, with traffic instructions enclosed, via Airborne Express. This process is automated for production studios, agencies, or media buyers who upload spots or place distribution orders, and there is no additional cost. 206-753-3930, www.spottaxi.com.
New releases from AVDeli include: Mars, 9 CDs of imaging tools for Hot AC, Mix AC, and Pop Alternative; Files, 4 CDs of imaging tools and promo scores for Alternative and Active Rock stations; All American Country, 10 CDs of sound designer tools and 200+ rhythmic beats and 26)+ Pop Country promo scores; PowerPop, 5 CDs with over 1000 cuts—workparts, loops, beats, and promo scores for Pop radio imaging; Zen, 5 CDs of imaging tools and promo scores for Mainstream AC and Lite Rock formats; Ecstasy, 7 CDs of imaging and remix tools created in Ibiza, Spain for Rhythmic CHR formats; and Rock On!, 10CDs of sound designer tools and promo scores for AOR and Classic Rock radio. All libraries are a buyout and range in price from $595 to $1995. (262) 632-8610, www.avdeli.com.
Don Elliot Creative Services adds two new CD’s to the series: Don Elliot, The Legend. Disc 11: Campaign 2000 ELECT-ricity is a 21 cut package of fully orchestrated music for political campaigns or for radio-TV news coverage of political events. One year blanket $195. Disc 12: The Final Answer features cuts you can use for game-shows, quizzes, contests, promotions, and tie-ins. The suspense beds, the hits, impacts and stingers are in the same key for you to layover for emphasis. Buyout $99. Voiceovers@ earthlink.net, 818-241-4650 voice and fax.
Promusic introduces the Editors Construction Kit, a set of 4 production CDs from the Cavendish library designed to enable sound engineers, designers and editors to create sound tracks unique to each production. The CDs work by having each track in keys and tempos that work together. Editors can choose atmospheric beds to suit their projects and add elements to build tracks that are in synch with video action. In this way, each track is in effect unique to their production and tightly tailored as a specially composed score would be. . (818) 506-1588, www.promusic-inc.com.
Hedquist Productions of Fairfield, IA has completed production of their 20th Chicken Soup for the Soul CD and cassette tape, Chicken Soup for the Writer’s Soul. This latest collection of stories from the New York Times’ best-selling series contains inspiring stories for and about writers. (515) 472-6708, fax (515) 472-7400.
Announcing the (alleged) upcoming 2XS (Palmerston North, Manawatu, New Zealand) Staff Reunion. Whether it’s a 20th or 21st Anniversary is yet to be decided. At this stage, plans are afoot for the 20th, so keep Queen’s Birthday Weekend 2001 free (June 2 - 4). I’d like to start building up a database of addresses, so if you are a former employee at 2XS, or you know where some are, send addresses, phone numbers, e-mails etc. to Jon Hogan, PO Box 47 524, Ponsonby, Auckland, New Zealand, e-mail me at [email protected], or phone RadioWorks Network 0064 9 375 7171.
From JazzRadio in Berlin to Atlantic 252, a long-wave British Top 40 station, BroadcastAMERICA.com is now providing an Internet gateway to the best in live European radio with its launch of BroadcastEUROPE.com. Broadcast EUROPE.com has opened offices in Berlin and Oldenbrug, Germany, and Glasgow, Scotland, and is reaching out to stations throughout Europe to add to the site. The company recently signed with a group of 15 stations in Scotland and Ireland, which will be added to the site within the next month.
Australian based MCM Entertainment is compiling its own production website, which will feature promos, sweepers, and creative commercials from Australian and international producers. Initially, the website will be free of charge to subscribers who want to keep up to date with what other producers are doing and how creatively they’re doing it. This is also an opportunity to get your work heard around the globe as your station and name would appear next to your work. The website is designed to inspire production teams and become a beneficial way of receiving feedback. For subscription info, contact Lana Reed at (61) 3-9639-2933 or e-mail [email protected].
Net Radio (www.netradio.com) an Internet-only streaming audio Web site, claimed five out of the six leading slots in Arbitron’s February 2000 Infostream Webcast report. NetRadio’s “Hits Channel” and “80s Hits” were ranked first and second. International Webcaster, Virgin Radio (www.virginradio.co.uk) based in the UK was ranked number three.
Circuit Research Labs, Inc. (CRL) announced the appointment of Bob Orban and Phillip T. Zeni, Sr., to its Board of Directors. Bob Orban is the founder and chief engineer of Orban, which CRL recently acquired from Harman International Industries, Inc. Zeni is a highly successful publisher, businessman, Internet pioneer and author. He currently serves as president of magazine publisher Transcontinental Publishing, Inc., as executive vice president of Palmieri USA, an importer of construction equipment, and as managing director of PhysicianNet.com. He had earlier served as managing partner of a Dallas-based group of broadcasting stations and as director of business development for NBC Radio and Westinghouse-Group W Broadcasting in Chicago. (510) 351-3500, fax (510) 351-0500, www.crlsystems.com, www. orban.com. | 2019-04-21T08:08:00 | https://rapmag.com/a/74-00/aug00/1960-production-news-august-2000 |
Was born on August 25, in 1962 in the city of Kartaly, in the south of the Chelyabinsk region.
After graduation from the industrial school for a long time worked as a photographer, from technical to reporter photography.
In 1988 he graduated from Chelyabinsk State Institute of Culture.
Graduated from the All-Union correspondence faculty of photojournalism at the Union of Journalists of the USSR, which allowed him to collaborate with local papers.
After injuries sustained in a car accident in 1994 which included impaired vision, Valeriy Anatolievich was forced to leave the visual work for many years.
Then, coming back to it, he worked as a designer of outdoor advertising in different agencies.
Stock Photo and 3D objects modeling led him to freelance.
He was a participant in numerous competitions of automobile design.
But, unlike these activities, ideas of cartoons and genre scenes never left him.
← “Kolašin , Montenegro 2017” has announced The Second International Cartoon Contest. | 2019-04-24T14:04:31 | http://cartoonia.ru/entsiklopediya-karikatury/o/%D1%80%D1%83%D1%81%D1%81%D0%BA%D0%B8%D0%B9-%D0%BE%D1%81%D0%B8%D0%BF%D0%BE%D0%B2-%D0%B2%D0%B0%D0%BB%D0%B5%D1%80%D0%B8%D0%B9/ |
What are the new guidelines for the pharmacological management of obesity?
What information is available on the use of peramivir for treatment of influenza?
What data supports the use of new oral anticoagulants in special populations (hepatic impairment, obesity, pregnancy, lactation, and pediatrics)?
Obesity remains a prevalent, serious health issue in the United States. According to the Centers for Disease Control and Prevention (CDC), approximately 78.6 million American adults and 12.7 million children and adolescents (2 to 19 years of age) are obese.1,2 Obesity plays a significant role in some of the leading causes of preventable death including heart disease, stroke, type 2 diabetes, and certain cancers.1 In addition, the annual medical cost of obesity is considerable - $147 billion (2008 dollars) - with obese individuals experiencing significantly higher medical costs than those of normal weight.
In the 1960s, the Food and Drug Administration (FDA) approved the first agents for short-term (few weeks) adjunctive therapy of obesity in combination with exercise, behavioral modification, and caloric restriction – phentermine and diethylpropion.4-6 For almost 4 decades, these were the only approved agents for obesity management until the approval of orlistat, a gastrointestinal lipase inhibitor, in 1999.4,7 In 2012, lorcaserin and the combination of phentermine/topiramate were approved.8,9 Finally, in 2014, liraglutide and naltrexone/bupropion became available for chronic weight management.4,10,11 Table 1 summarizes general information regarding the available pharmacologic agents for obesity. The advantages and disadvantages associated with each weight loss medication including cost, degree of weight loss, long-term efficacy data, and safety profile were evaluated in the guideline.
The dose may be increased further if sufficient weight loss does not occur. The maximum available dose is 15 mg phentermine/92 mg topiramate.
*Alli is the over-the counter brand name for orlistat; Xenical is the prescription brand name. SC = subcutaneous.
The Endocrine Society-appointed Task Force of experts developed the guideline using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) system to describe the strength of recommendations and the quality of evidence.4 A summary of recommendations made by the Task Force is presented in Table 2.
Diet, exercise, and behavioral modification should be included in all approaches to obesity management for individuals with a BMI ≥ 25 kg/m 2 and other tools such as pharmacotherapy (BMI ≥ 27 kg/m2 with comorbidity or BMI > 30 kg/m2) and bariatric surgery (BMI ≥ 35 kg/m2with comorbidity or BMI > 40 kg/m2) be used as adjunctive therapy. Pharmacologic therapy may increase adherence to behavior modification and improve physical functioning so that exercise becomes easier with time. Candidates for obesity medications include patients who have a history of being unable to successfully lose and maintain weight and who meet label indications.
The administration of approved weight loss medications is suggested (versus no therapy) to ameliorate comorbidities and increase adherence to behavior modification in certain obese patients.
Phentermine and diethylpropion are not recommended for use in patients with uncontrolled hypertension or a history of heart disease.
For any patient prescribed pharmacologic therapy for obesity, efficacy and safety monitoring should occur at least monthly for the initial 3 months and then at least every 3 months thereafter.
If a patient’s response to pharmacologic therapy is effective (i.e., weight loss ≥ 5% of body weight after 3 months) and safe, treatment should be continued. If there is a lack of response or safety issues occur, therapy should be discontinued and an alternative treatment approach undertaken.
If pharmacologic therapy for chronic weight management is undertaken, dosing should be initiated at the lowest dose and escalated based on efficacy and tolerability to the recommended dose. Administering doses above the maximum approved dose is not recommended.
For obese patients with type 2 diabetes, administration of a GLP-1 analog or SGLT2 inhibitor is recommended to promote weight loss in addition to the recommended first line agent, metformin.
Lorcaserin and/or orlistat are recommended weight loss agents for patients with cardiovascular disease.
Beyond the recommendations in Table 2, the guideline discusses the need to consider alternatives to medications that cause weight gain for various disease states and conditions including type 2 diabetes, hypertension, depression, epilepsy, schizophrenia, human immunodeficiency virus (HIV) infection, chronic inflammatory diseases such as rheumatoid arthritis, and contraception.4 Examples include recommendations to use weight-neutral antipsychotics and oral contraceptives over injectable formulations if possible. Finally, the guideline suggests against the off-label use of medications approved for other disease states for the sole purpose of weight loss.
Obesity continues to be a serious health concern for millions of American adults and children. The cornerstone of obesity management includes increased physical activity and reduced caloric intake; however, other approaches such as surgery and drug therapy also play a role. A recent Endocrine Society evidence-based practice guideline emphasizes that the appropriate adjunctive use of pharmacologic therapy may increase adherence to behavior modifications and improve physical functioning in obese patients.
1. Adult obesity facts. Centers for Disease Control and Prevention.http://www.cdc.gov/obesity/data/adult.html. Accessed February 9, 2015.
2. Childhood obesity facts. Centers for Disease Control and Prevention.http://www.cdc.gov/obesity/data/childhood.html. Accessed February 9, 2015.
3. Jensen MD, Ryan DH, Apovian CM, et al. 2013 AHA/ACC/TOS guideline for the management of overweight and obesity in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and The Obesity Society. Circulation. 2014;129(25 Suppl 2):S102-S138.
4. Apovian CM, Aronne LJ, Bessesen DH, et al. Pharmacological management of obesity: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2015;100(2):342-362.
5. Phentermine [package insert]. Phoenix, AZ: Apotheca; 2010.
6. Diethylpropion [package insert]. Philadelphia, PA: Lannett Company, Inc.; 2011.
7. Xenical [package insert]. South San Francisco, CA: Genentech; 2013.
8. Belviq [package insert]. Woodcliff Lake, NJ: Eisai; 2014.
9. Qsymia [package insert]. Mountain View, CA: Vivus, Inc.; 2014.
10. Contrave [package insert]. La Jolla, CA; Orexigen Therapeutics, Inc.; 2014.
11. Saxenda [package insert]. Plainsboro, NJ: Novo Nordisk, Inc.; 2015.
There are 3 types of seasonal influenza viruses – A, B and C.4,5 Type A influenza viruses are classified into subtypes according to the combination of the surface proteins, hemagglutinin and neuraminidase. Currently, the subtypes influenza A (H1N1) and A (H3N2) are found in humans. Influenza B is classified by lineages and strains, including B/Yamagata and B/Victoria. It is less common but causes significant morbidity. Type C influenza occurs much less frequently than A and B and causes only mild upper respiratory tract illness; therefore, it is not included in seasonal influenza vaccines.
Prior to December 2014, 4 prescription influenza antiviral agents were approved by the US Food and Drug Administration (FDA): oral oseltamivir (Tamiflu®), inhaled zanamivir (Relenza®), amantadine (Symmetrel®), and rimantadine (Flumadine®).6 Oseltamivir and zanamavir are neuraminidase inhibitors that have activity against both influenza A and B viruses. Amantadine and rimantadine are adamantanes that are only active against influenza A viruses. During the past influenza seasons, there has continued to be high levels of resistance (>99%) to adamantanes among common influenza A strains. As a result of increasing resistance and lack of activity against the influenza B virus, amantadine and rimantadine are not recommended by the Center for Disease Control (CDC) for antiviral treatment or chemoprophylaxis.
Oral or inhaled administration of the recommended antivirals to patients with severe symptoms or patients who require respiratory therapy can be difficult. The development of an anti-influenza medication in an injectable form could be beneficial for critically ill influenza patients with severe or life-threatening symptoms for whom oral or inhalation administration would be challenging. In 2009, the FDA granted an emergency use authorization to use IV peramivir, which was commercially available in Japan at the time, for the influenza A (H1N1) pandemic.
On December 19, 2014, the FDA approved intravenous (IV) peramivir (Rapivab®), a third neuraminidase inhibitor with activity against influenza A and B, to treat influenza in adults for the 2014-2015 influenza season. Table 1 summarizes the current FDA indications and the CDC and American Academy of Pediatrics (AAP) recommendations for use of antiviral medications for the treatment of influenza.
aOral oseltamivir is FDA approved for the treatment of acute uncomplicated influenza in patients 14 days and older and for chemoprophylaxis in persons 1 year and older. However, use of oral oseltamivir for treatment of influenza in patients younger than 14 days old, including preterm infants, is recommended by the CDC and the AAP bZanamivir is contraindicated in patients with history of allergy to milk protein. cPeramivir efficacy is based on clinical trials in which the predominant influenza virus type was influenza A.
Abbreviations: COPD=chronic obstructive pulmonary disease; N/A=not applicable.
The safety and efficacy of peramivir in adult patients has been evaluated in multiple clinical trials.11-16 A majority of these studies occurred in Japan and other Asian countries due to the approved use of peramivir for influenza since 2010. Table 2 summarizes select published clinical trials of peramivir in adults. In an effort to determine utility of IV peramivir in high-risk hospitalized patients, de Jong and colleagues compared the time to symptom resolution in 338 patients who received a single peramivir dose to patients who received standard of care with or without use of another neuraminidase inhibitor.11 At interim analysis, no significant difference in outcome was observed between the groups and due to the need to recruit a greater number of patients, the trial was terminated.
A multinational, Phase II randomized, double-blind trial evaluated the efficacy and safety of IV peramivir 200 mg and 400 mg compared to oral oseltamivir in 137 hospitalized patients.12Peramivir at both doses demonstrated similar efficacy (clinical stability) to oseltamivir; however, the study did not include critically ill patients and did not meet the prespecified power to detect a difference between groups. Furthermore, the doses used in this Phase II trial are lower than the currently FDA-approved dose.
In 2 trials of outpatients with confirmed influenza, a single dose of 300 mg or 600 mg peramivir demonstrated noninferiority to a 5-day treatment course of oseltamivir 75 mg twice daily in over 1000 outpatients and superiority compared to placebo in close to 300 outpatients in time to alleviation of symptoms.13,15 These studies did not include high-risk patients who required hospitalization.
In a smaller study of 37 patients, the efficacy and safety of multiple doses of IV 300 mg and 600 mg peramivir was evaluated in those at high-risk requiring hospitalization.14 Over 60% received treatment for 2 days and 27% of patients received treatment for 1 day. The higher dose of peramivir demonstrated a shorter duration of illness and a shorter time to normalization of body temperature. Due to the small sample size of this study and lack of a comparator agent, this study demonstrated potential, but not proven, efficacy of multiple doses of peramivir in high-risk influenza patients requiring hospitalization. Gastrointestinal symptoms such as nausea and diarrhea were the most common adverse drug reactions reported in these trials.
Efficacy and safety outcomes of adult and pediatric patients with confirmed influenza between October 2010 and February 2012 who received peramivir in Japan were obtained in a post-marketing observational study.16 Adults received 300 mg or 600 mg (for severe symptoms or complications) IV peramivir infused over at least 15 minutes. Children received 10 mg/kg/day as a single dose up to a maximum of 600 mg. Of the 1174 patients, 83% were adults (defined as 15 to 64 years of age), 5.9% were younger than 15 years and 11.1% were 65 years or older. Only 3.2% were inpatients. Fever and symptom resolution occurred at a median time of 3 days in over 65% of patients. Diarrhea (1.87%), vomiting (0.85%), and nausea (0.68%) were the most common adverse drug reactions. Adverse drug reactions occurred within 3 days of treatment and resolved within one week of onset.
Although peramivir is not FDA-approved for pediatric use, a multi-center, open-label study evaluated its efficacy and safety in children with pH1N1 virus infection.17 A study in 115 pediatric patients ages 28 days to 16 years examined the time to alleviation of influenza symptoms. Peramivir 10 mg/kg IV (maximum dose 600 mg) was administered over 15 to 60 minutes once daily for up to 5 days if body temperature was ≥38°C or if the patient was symptomatic. Of the pH1N1 population (n=106), 105 patients (91.3%) were treated for 1 day and 10 patients (8.7%) were treated for 2 days. The median time to alleviation of influenza symptoms was 29.1 hours (95% confidence interval [CI], 22.1 to 32.4) in the pH1N1 population and 27.9 hours (95% CI, 21.7 to 31.7) in the intent-to-treat infected population. The median time to resolution of fever was 20.6 hours (95% CI, 19.4 to 21.1.) in the pH1N1 population and 20.4 hours (19.1 to 20.9) in the intent-to-treat infected population. The most common adverse events were diarrhea (16.2%) and a decrease in neutrophil count (21.4%). A higher incidence of adverse events tended to be observed in younger children.
In a single-center, non-randomized study in Japan conducted between February and April 2011, 223 pediatric patients under the age of 18 years with confirmed influenza received one of 4 antiviral drugs (laninamivir 20 mg inhalation for patients < 10 years and 40 mg inhalation for patients 10 years or older, peramivir 10 mg/kg IV with a maximum of 300 mg as a single dose infused over 15 minutes, oseltamivir 4 mg/kg/day in 2 divided doses with a maximum of 150 mg/day for 5 days, zanamivir 20 mg/day in 2 divided doses for 5 days).18 The median age (range) of patients who received the antivirals were laninamivir, 132.5 months (80 to 164); oseltamivir, 56.5 months (3 to 135); peramivir, 76 months (2 to 219); and zanamivir, 124.5 months (59 to 198). For patients between ages 0 and 9 years who received oseltamivir or peramivir, the median duration of fever was not significantly different: 2 days (range 0 to 6 days) and 1.5 days (range 1 to 3 days), respectively (p=0.4499). When compared to zanamivir and laninamivir in patients between 5 and 18 years, peramivir reduced fever duration by 1 to 2 days which was considered to be statistically significant. No adverse events were reported in this study.
A post-marketing observational study in over 1100 Japanese children 15 years of age or younger evaluated the safety and efficacy of peramivir in patients who received the antiviral between October 2010 and February 2012.19 In terms of age range, slightly over 4% of the patients were between 4 weeks and 1 year of age, 44% were between 1 and 7 years, and 51.4% were between 7 and 15 years. Slightly over 11% of the patients were inpatient. Over 96% of patients received treatment for 1 day. Approximately 60% of patients had alleviation of symptoms in 3 days and close to 80% of patients had resolution of fever in 3 days. Incidences of some common adverse events were diarrhea (3.1%), abnormal behavior (3%), vomiting (1.5%), and decreased neutrophil count (1.5%). A majority of these adverse events occurred within 3 days of treatment and resolved within 7 days of occurrence. Patients with underlying conditions, severe influenza symptoms, on concomitant medications, and who received 2 or more doses of peramivir were more likely to experience an adverse event.
The results of these studies are promising; however, due to the open-label, unblinded, observational, and non-randomized design of these studies, the efficacy and safety of peramivir in children needs to be further demonstrated in larger, randomized, comparative trials.
· Time to clinical resolution in patients receiving peramivir plus standard of care compared to patients who received standard of care alone was 42.5 h (95% CI 40.0 to 61.9) vs. 49.5 h, respectively (95% CI 34.0 to 57.9; p=0.97).
· Time to clinical resolution in patients receiving peramivir plus standard of care compared to patients who received another neuraminidase inhibitor plus standard of care was 41.8 h (95% CI 30.9 to 56.8) vs. 48.9 (95% CI 31.0 to 65.8, p=0.74).
· No statistically significant differences in the secondary endpoints were observed between the treatment groups.
· Common adverse events related to medication included GI effects and were similar between treatment groups.
· Serious adverse events of pneumonia, COPD, septic shock, acute respiratory distress were attributed to influenza complications.
· Clinical stability by treatment with peramivir 400 mg, peramivir 200 mg, or oseltamivir was 37 h (22 to 48.7), 23 h (16 to 38.9) and 28 h (22 to 37), respectively (p=0.306).
· No significant differences were present for alleviation of influenza symptoms during treatment, 89.5 h (49.6 to 204.4), 70.3 h (60.5 to 97), and 73 h (48.1 to 96.5) for peramivir 400 mg, peramivir 200 mg and oseltamivir, respectively (p=0.783).
· Five (4%) patients required ICU admission during the first days of study treatment.
· There were no significant differences in time to hospital discharge, 3.8 h (2.7 to 4.8), 4 h (3 to 4.7), 4 h (2.9 to 4.6) for peramivir 400 mg, peramivir 200 mg and oseltamivir, respectively (p=0.994).
· None of the patients with confirmed influenza died during the study period.
· Patients treated with peramivir had a shorter median times to resumption of usual activities: 9 days, 8.8 days, and 13.7 days for peramivir 400 mg, peramivir 200 mg and oseltamivir, respectively (p=0.276).
· A higher proportion of patients who received peramivir experienced ≥1 AE than those who received oseltamivir.
· Gastrointestinal AEs (mainly due to higher frequency of diarrhea) were reported in 33% of subjects for peramivir 200 mg, 28% for peramivir 400 mg, and 15% for oseltamivir.
· Serious AEs occurred in 8 patients treated with peramivir 400 mg, in 2 patients treated with peramivir 200 mg and in 4 treated with oseltamivir.
· There were no adverse changes in routine hematology or chemistry values.
Treatment duration was 5 days.
The concomitant use of acetamino-phen was allowed, but other antipyretics, antivirals, and antimicro-bials were not permitted.
· The median times to alleviation of symptoms were 78 h (95% CI 68.4 to 88.6), 81 h (95% CI 72.7 to 91.5), and 81.8 h (95% CI 73.2 to 91.1) in peramivir 300 mg, peramivir 600 mg, and oseltamivir groups, respectively.
· The HR for time to alleviation of symptoms for the peramivir 300 mg and 600 mg groups compared to the oseltamivir group were 0.946 (97.5% CI 0.793 to 1.129) and 0.97 (97.5% CI 0.814 to 1.157), respectively.
· Both peramivir groups demonstrated noninferiority to oseltamivir (97.5% CI <1.17).
· The proportion of patients whose body temperatures returned to normal 24 h after treatment was significantly higher in the peramivir 300 mg and 600 mg groups (59.3%, p=0.0272 and 57.9%, p=0.0326, respectively) than in the oseltamivir group (49.7%).
· The median times to resumption of usual activity were 155.7 h, 195.5 h, and 171.3 h in the peramivir 300 mg, peramivir 600 mg, and oseltamivir groups, respectively.
· The incidence of influenza-related complications for the peramivir 300 mg group was 1 case (0.3%) of sinusitis, 6 cases (1.6%) of bronchitis, 3 cases (0.8%) of pneumonia; for the peramivir 600 mg group there was 1 case (0.3%) of sinusitis, 1 case (0.3%) of otitis media, 6 cases (1.7%) of bronchitis, and 1 case (0.3%) of pneumonia; for the oseltamivir group there were 4 cases (1.1%) of sinusitis, 6 cases (1.6%) of bronchitis, and 2 cases (0.5%) of pneumonia.
· The time-weighted change from baseline in the A/H3N3 infected subpopulation in the peramivir 300 mg was greater than the oseltamivir group (p=0.0386 at day 2 and p=0.0218 at day 3).
· The incidence of ADRs (14%, 18.1%, and 20% in the peramivir 300 mg, peramivir 600 mg, and oseltamivir groups, respectively) was significantly lower in the peramivir 300 mg group (p=0.0382) and nonsignificantly lower in the peramivir 600 mg group (p=0.5718) than in the oseltamivir group.
· The common ADRs in the 3 treatment groups included diarrhea, nausea and a reduced neutrophil count. Compared to peramivir 600 mg, only nausea was numerically more frequent with oseltamivir. (1.9% vs. 4.4%).
· Prolonged QT interval and reduced neutrophil count was observed in the peramivir groups.
Doses were administered IV over a period of 15 to 60 min for 1 to 5 days according to the repeated dosing criteria (temperature ≥37.5⁰C or clinical judgment).
Use of aceta-minophen was permitted.
· The median duration of influenza illness was 68.6 h in all patients (90% CI 41.5 to 113.4) , 114.4 h (90% CI 40.2 to 235.3) in the peramivir 300 mg group, and 42.3 h (90% CI 30 to 82.7) in the peramivir 600 mg group.
· 62% of patients received treatment for 2 days and 27% received 1 day treatment.
· HR for duration of illness for the 600 mg group compared to 300 mg was 0.497 (90% CI 0.251 to 0.984).
· The median duration of influenza illness was 92 h (90% CI 14.6 to 235.3; n=10) in the single dose patients and 64.1 h (90% CI 41.5 to 111.2; n=27) in multiple dose patients.
· The median time until body temperature normalized (˂37⁰C) was 40.2 h (90% CI, 34.2 to 53.8) for the total group, 57.1 h (90% CI, 34.2 to 75.1) for the 300 mg group, and 37.6 h (90% CI, 22.3 to 46.8) for the 600 mg group. The time to temperature normalization for the peramivir 600 mg group was also significantly shorter than that for the peramivir 300 mg group (HR 0.375, 90% CI 0.182 to 0.770).
· The mean influenza virus titers on day 2 in patients with positive virus titers at the time of enrollment were 1.9±1.88 overall, 2.29±2.52 in the peramivir 300 mg group, and 1.59±1.12 in the peramivir 600 mg group. The titers on day 3 were 1.9±1.88 overall, 2.09±2.42 in the peramivir 300 mg group, and 0.69±0.65 in the peramivir 600 mg group. The titers on day 6 were below the limit of detection (0.5) in both groups.
· The proportion of influenza virus-positive patients overall was 71% on day 2 (71.4% peramivir 300 mg, 70.6% peramivir 600 mg) after the start of administration, 31.3% on day 3 (46.7% peramivir 300 mg, 17.6% peramivir 600 mg), and 0% on day 6.
· The incidence of influenza-associated complications was 10.8%. The most common influenza-associated complication was pneumonia in 8.1% of patients.
· The incidence of ADRs was 33.3%. 11 ADRs occurred in 28.6% of pts in the peramivir 300 mg group and 10 ADRs occurred in 38.1% of pts in the peramivir 600 mg group.
· The major events (≥3 instances of either an AE or ADR) were abnormal changes in clinical test values, including increased blood glucose levels and decreased neutrophil counts, in addition to diarrhea, pneumonia, and oral herpes infection.
Over 95% of patients had influenza A.
The study drug was infused over 30 to 60 min.
Use of aceta-minophen was allowed.
· The median time to alleviation of symptoms was significantly reduced in the peramivir treatment groups compared to placebo (peramivir 300 mg 59.1 h, 95% CI 50.9 to 72.4; peramivir 600 mg 59.9 h, 95% CI 54.4 to 68.1; placebo 81.8 h, 95% CI 68 to 101.5). The HR of treatment to placebo for the time to alleviation of symptoms was 0.681 (95% CI, 0.511 to 0.909, adjusted p=0.0092) in the 300 mg group and 0.666 (95% CI 0.499 to 0.89, adjusted p=0.0092) in the 600 mg group.
· The efficacy of peramivir was apparent as early as 24 h after the start of treatment.
· The proportion of afebrile subjects was increased by treatment, and a reduction in fever was evident within 24 h of therapy.
· At baseline, the viral titers were similar for all 3 groups; however, on day 3, the proportions of virus-positive subjects were significantly decreased in the 300 mg (36.8%, p=0.0485) and 600 mg (25.8%, p=0.0003) groups compared to placebo (51.5%).
· Virus was not detected in most subjects on day 9 (300 mg, 0%; 600 mg, 1.1%; placebo 0%).
· Peramivir recipients reported shorter times to resumption of their usual activities (43.6 h and 41.7 h earlier in the 300 mg and 600 mg groups, respectively; 300 mg median duration 125.6 h (95% CI 103.8 to 148.5, p=0.0367), 600 mg 127.4 h (95% CI 122.1 to 153.1], p=0.0152), and placebo 169.1 h [95% CI, 142 to 180]).
· Physician-diagnosed secondary complications (pneumonia, bronchitis, sinusitis, and otitis media) occurred in 3 recipients (3%) of 300 mg peramivir (bronchitis), 1 recipient (1%) of 600 mg peramivir (otitis media), and 3 (3%) placebo recipients (bronchitis).
· Most AEs were mild to moderate and were GI-related (diarrhea occurred in 14.1%, 15.2%, and 17% and nausea occurred in 3%, 6.1%, and 1% in the 300 mg, 600 mg and placebo groups, respectively).
· Severe AEs occurred in 2 subjects (2%) in the 300 mg group (3 – prolonged QT interval, 3 subjects (3%) in the 600 mg group (1 – prolonged QT interval, 1 – increased blood glucose, and 1 – increased blood creatinine), and 5 subjects (5%) in the placebo group (3 – prolonged QT interval, 1 – increased BP, 1 – increased blood glucose).
· The other severe AEs were attributed to influenza virus infection or its complications.
Abbreviations: AE(s)=adverse event(s); ADR(s)=adverse drug reaction(s); BP=blood pressure; CI=confidence interval; COPD=chronic obstructive pulmonary disease; DB=double-blind; DD=double-dummy; GI=gastrointestinal; HR=hazard ratio; ICU=intensive care unit; ITTI, intent-to-treat infected; IV=intravenously; MC= multicenter; NI= non-inferiority; PC=placebo controlled; PO=orally; R=randomized; RCT=randomized controlled trial; VAS=visual analog scale.
Peramivir is a cyclopentane analogue neuraminidase inhibitor that selectively inhibits the influenza virus neuraminidase enzyme preventing the release of viral particles from infected cells.10 Peramivir is indicated for the treatment of acute, uncomplicated influenza in patients 18 years and older as a 600 mg single dose IV infusion over 15 to 30 minutes within 2 days of symptom onset. Peramivir can be prepared in 0.9% or 0.45% NaCl, 5% dextrose, or lactated ringers (maximum volume of 100 mL) and should be administered immediately or refrigerated for up to 24 hours. The manufacturer does not recommend mixing or co-infusing peramivir with other IV medications.
In controlled clinical trials including patients with influenza, diarrhea and other gastrointestinal adverse effects were reported with peramivir, but the incidence was similar to that with placebo.11-19 Neutropenia has occurred in patients receiving peramivir. Serious skin reactions, including erythema multiforme and Stevens-Johnson syndrome, have occurred rarely.10 Neuropsychiatric events, including self-injury and delirium, which can be a complication of influenza illness, have been reported in patients with influenza taking neuraminidase inhibitors, including peramivir. Administration of peramivir within 48 hours before or less than 2 weeks after administration of the intranasal live attenuated influenza vaccine (FluMist Quadrivalent®) may reduce the vaccine’s efficacy and should be avoided. Inactivated influenza vaccine can be administered at any time relative to use of peramivir.
Influenza virus A and B isolates with neuraminidase amino acid substitutions associated with reduced susceptibility to peramivir and oseltamivir have been recovered in clinical trials.22Neuraminidase inhibition assays have found that some influenza A/H1N1 strains that are resistant to oseltamivir and peramivir remain susceptible to zanamivir.
Neuraminidase inhibitors are currently the drugs of choice for treatment of patients with influenza and are most effective when started within 48 hours of symptoms onset.4,6Currently, none of the neuraminidase inhibitors is approved for use in hospitalized or critically ill patients. Although approved by the FDA only for treatment of uncomplicated influenza in outpatients, the off-label use of peramivir, an IV drug, to treat hospitalized patients may be needed. Given the high mortality among the critically ill, the World Health Organization (WHO) and CDC recommend that all critically ill patients receive oseltamivir orally or via nasogastric tube. In patients unable to take oseltamavir, IV peramivir or investigational IV zanamivir should be considered.
Peramivir is the first neuraminidase inhibitor to be FDA-approved for IV administration and shows efficacy for the treatment of seasonal and pH1N1 influenza. Peramivir has demonstrated non-inferior efficacy to oral oseltamivir for treatment of adults with uncomplicated influenza. Additionally, efficacy and safety in children has been suggested in small, uncontrolled trials. The availability of an IV antiviral influenza agent is promising and its efficacy in hospitalized, critically ill adults and children remains to be established.
1. Zhou H, Thompson WW, Viboud CG et al. Hospitalizations associated with influenza and respiratory syncytial virus in the United States, 1993-2008. Clin Infect Dis. 2012;54(10):1427-1436.
2. Thompson WW, Weintraub E, Dhakher P et al. Estimated of US influenza-associated deaths made using four different methods. Influenza Other Respi Viruses. 2009;3(1):37-49.
3. Ortiz JR, Neuzil KM, Shay DK et al. The burden of influenza-associated critical illness hospitalizations. Crit Care Med. 2014;42(11):2325-2332.
4. World Health Organization. Influenza (Seasonal). http://www.who.int/mediacentre/factsheets/fs211/en/. Updated March 2014. Accessed January 30, 2015.
5. Centers for Disease Control and Prevention. Types of influenza viruses. http://www.cdc.gov/flu/about/viruses/types.htm. Updated August 19, 2014. Accessed February 19, 2015.
6. Centers for Disease Control and Prevention. Influenza antiviral medications: summary for clinicians. http://www.cdc.gov/flu/professionals/antivirals/summary-clinicians.htm. Updated January 9, 2015. Accessed January 30, 2015.
7. American Academy of Pediatrics Committee on Infectious Diseases. Recommendations for prevention and control of influenza in children, 2013-2014. Pediatrics. 2013;132(4):e1089-e1104.
8. Tamiflu [package insert]. San Francisco, CA: Genetech, Inc.; 2014.
9. Relenza [package insert]. Research Triangle Park, NC: GlaxoSmithKline; 2013.
10. Rapivab [package insert]. Durham, NC: BioCryst Pharmaceuticals, Inc.; 2014.
11. de Jong MD, Ison MG, Monto AS, et al. Evaluation of intravenous peramivir for treatment of influenza in hospitalized patients. Clin Infect Dis. 2014;59(12):e172-e185.
12. Ison MG, Hui DS, Clezy K et al. A clinical trial of intravenous peramivir compared with oral oseltamivir for the treatment of seasonal influenza in hospitalized adults. Antivir Ther. 2013;18(5):651-661.
13. Kohno S, Yen MY, Cheong HJ et al. Phase III randomized, double-blind study comparing single-dose intravenous peramivir with oral oseltamivir in patients with seasonal influenza virus infection. Antimicrob Agents Chemother. 2011;55(11):5267-5276.
14. Kohno S, Kida H, Mizuguchi M et al. Intravenous peramivir for treatment of influenza A and B virus infection in high-risk patients. Antimicrob Agents Chemother. 2011;55(6):2803-2812.
15. Kohno S, Kida H, Mizuguchi M et al. Efficacy and safety of intravenous peramivir for treatment of seasonal influenza virus infection. Antimicrob Agents Chemother. 2010;54(11):4568-4574.
16. Komeda T, Ishii S, Itoh Y, et al. Post-marketing safety and effectiveness evaluation of the intravenous anti-influenza neuraminidase inhibitor peramivir (I): a drug use investigation.
17. Sugaya N, Kohno S, Ishibashi T et al. Efficacy, safety, and pharmacokinetics of intravenous peramivir in children with 2009 pandemic H1N1 influenza A virus infection.Antimicrob Agents Chemother. 2012;56(1):369-377.
18. Hikita T, Hikita H, Hikita F, et al. Clinical effectiveness of peramivir in comparison with other neuraminidase inhibitors in pediatric influenza patients.Int J Pediatr. 2012;2012:834181. doi: 10.1155/2012/834181.
19. Komeda T, Ishii S, Itoh Y, et al. Post-marketing safety and effectiveness evaluation of the intravenous anti-influenza neuraminidase inhibitor peramivir (II): A pediatric drug use investigation.J Infect Chemother. 2015;21(3):194-201.
20. Thomas B, Hollister AS, Muczynski KA. Peramivir clearance in continuous renal replacement therapy. Hemodial Int. 2010;14(3):339-340.
21. Scheetz MH, Griffith MM, Ghossein C et al. Pharmacokinetic assessment of peramivir in a hospitalized adult undergoing continuous venovenous hemofiltration. Ann Pharmacother. 2011;45(12):e64.
22. Nguyen HT, Sheu TG, Mishin VP et al. Assessment of pandemic and seasonal influenza A (H1N1) virus susceptibility to neuraminidase inhibitors in three enzyme activity inhibition assays. Antimicrob Agents Chemother. 2010:54(9):3671-3677.
In recent years, several new oral anticoagulants (NOACs) have been approved by the US Food and Drug Administration (FDA) for various disease states including stroke prophylaxis in atrial fibrillation (AF), venous thromboembolism (VTE) prophylaxis in major orthopedic surgery, and treatment and prevention of VTE.1-4 The efficacy and safety of these agents, and their therapeutic advantages compared to warfarin, have garnered interest among clinicians. However, there is little clinical experience with these medications in special populations. This article summarizes the available published evidence for apixaban, dabigatran, edoxaban, and rivaroxaban in the following populations: hepatic impairment, obesity, pregnancy, lactation, and pediatrics.
The liver plays only a minor role in the metabolism and elimination of all NOACs.1-4 Apixaban undergoes some cytochrome (CYP)-mediated elimination via 1A2, 2C8, 2C9, 2C19, and 2J2 enzymes and rivaroxaban is oxidatively metabolized by CYP 3A4/5 and 2J2.1,4 Dabigatran and edoxaban are not metabolized in the liver and undergo primarily renal elimination.2,3Although their pharmacokinetic properties do not make it likely that use in patients with hepatic impairment would lead to any major safety concerns, data supporting their safe use in this population is limited.5 In particular, patients with cirrhosis and/or impaired hepatic production of coagulation factors, or those with hepatorenal syndrome, may be at an increased risk of bleeding.
Recently, some data has been published regarding the use of NOACs in patients with cirrhosis. An in vitro study found that plasma from 14 patients with cirrhosis (n=9 Child-Pugh Class B, n=5 Child-Pugh Class C) demonstrated decreased total (51% and 55%) and mean (32% and 30%) thrombin generation in comparison to 11 control patients, after apixaban 25 ng/mL or 50 ng/mL, respectively, was added to each sample.6 This study suggests that patients with cirrhosis may be at increased risk of bleeding with apixaban use, and potentially other NOACs. However, 2 recent case reports/series describe effective use of apixaban and rivaroxaban in patients with cirrhosis for the treatment of portal vein thrombosis (PVT), without any bleeding complications. 7,8 In the first case, a 50 year-old male with Child-Pugh Class A cirrhosis due to nonalcoholic steatohepatitis, esophageal varices, and PVT received heparin followed by transition to rivaroxaban 20 mg daily.7 Baseline serum creatinine was normal (0.6 mg/dL) and the international normalized ratio was 1.1. The thrombus had completely resolved by 6 months of follow-up and the patient did not report any bleeding complications. The second article was a case series (n=5) of patients with Child-Pugh Class A cirrhosis who received either apixaban 2.5 mg twice daily or rivaroxaban 10 to 20 mg daily for treatment of PVT.8 During follow-up (durations ranging from 1 to 7 months), the authors reported that therapy was well-tolerated and no patients experienced bleeding complications. These promising results now need to be confirmed in larger, prospective settings before widespread use of NOACs in patients with cirrhosis can be recommended.
A Phase I pharmacokinetic study with apixaban included 18 healthy subjects with mean body weight 137 kg (range 120 to 175 kg) and mean body mass index (BMI) ≥ 42.6 kg/m2 (range 32 to 54 kg/m2).14 Following a single dose of apixaban 10 mg, the mean apixaban maximum concentration (Cmax) and area under the curve (AUC) were 31% and 23% lower, respectively, compared to subjects with more normal body weight (65 to 85 kg). The apparent volume of distribution was 24% larger and the half-life was 3 hours shorter in obese subjects compared to subjects with normal body weight. There was a trend toward lower plasma anti-factor Xa activity with increasing body weight. Overall, the authors concluded that the differences in apixaban exposure with obesity were modest and not likely to be clinically significant; therefore, no dose adjustment based on body weight was recommended.
Two published reports describe use of dabigatran in obese patients.15,16 The first article is a post-hoc pooled analysis of dabigatran 220 mg daily in 896 patients with BMI >30 kg/m2 for the prevention of VTE following major orthopedic surgery.16 Data were obtained from 3 major clinical trials (RE-MODEL, RE-NOVATE, and RE-NOVATE II).21-23 Among all patients who received dabigatran in these trials, 22.6% had BMI >30 to 35 kg/m2, 6.9% had BMI >35 to 40 kg/m2, and 2% had BMI >40 kg/m2. The composite primary endpoint of major VTE and VTE-related mortality occurred at a similar rate in obese and non-obese patients (2.7% vs 2.1%). Obese patients also had a similar rate of the primary endpoint compared to patients who received enoxaparin 40 mg daily (2.9%, p=0.797). There were no differences in bleeding between groups. The 220 mg dose cannot be achieved with the dabigatran formulations currently available in the US (75 and 150 mg capsules), but these results do provide some reassurance regarding the safety and efficacy of dabigatran in obese patients. The other published report with dabigatran is a case report describing an acute ischemic stroke in a 48 year-old obese patient (153 kg, BMI 44.7 kg/m2) who had been taking dabigatran 150 mg twice daily for the prior 4 weeks for paroxysmal AF with purportedly good compliance.15 The dabigatran plasma level at presentation (patient-reported 9 hours after the most recent dose), as assessed by the Hemoclot thrombin inhibitor assay, was undetectable. Dabigatran therapy was continued following thrombolysis and plasma level monitoring demonstrated a peak plasma level of 50 ng/mL 4 hours post-dose at steady state. The authors report that this peak level was less than the 25th percentile of the therapeutic trough level. In response to the potentially sub-therapeutic dabigatran dose, therapy was switched to a coumarin anticoagulant. Further prospective data regarding the efficacy of dabigatran in patients with obesity are needed.
Among the NOACs, rivaroxaban has the largest number of published reports describing its use in obese patients.17,18,20 Similar to the apixaban study described previously, a single-center, randomized, single-blind, placebo-controlled study was conducted to evaluate the pharmacokinetics of rivaroxaban in healthy subjects.17 A total of 12 obese subjects (mean weight 132.2 kg, mean BMI 43.5 kg/m2 ) received a single 10 mg dose of rivaroxaban. There were no differences in Cmax, AUC, time to maximum concentration (tmax) or half-life between obese and non-obese subjects. Pharmacokinetic data for rivaroxaban were also published in a case report of a 67 year-old obese patient with acute ischemic stroke due to previously undiagnosed nonvalvular AF.20 Ten days after the stroke, the patient was started on dabigatran 150 mg twice daily. Hemoclot assay results after 1 week of therapy indicated that the patient did not reach the interquartile range for Cmax and most readings were below the interquartile range of trough concentration (Ctrough). In response, the patient was switched to rivaroxaban 20 mg daily; DiXal direct factor Xa inhibitor assay peak and trough results suggested effective anticoagulation.
In summary, apixaban and rivaroxaban have fairly predictable pharmacokinetic profiles in obese patients but no data are available regarding therapeutic efficacy in this population. Dabigatran does have some clinical outcome data in obese patients but the case reports suggesting lack of efficacy are concerning. No conclusion can be made regarding edoxaban since published data in obese patients is lacking.
There is limited information regarding the safe use of NOACs in pregnant patients. Apixaban is FDA pregnancy category B, while dabigatran, edoxaban, and rivaroxaban are pregnancy category C. 1-4 The product labeling for rivaroxaban contains a warning regarding the risk of pregnancy-related hemorrhage but this seems to be a general risk of all anticoagulants rather than a specific risk of rivaroxaban.4 Rivaroxaban is the only agent with a published case report of its use in pregnancy.24 A 24 year-old woman with a history of recurrent VTE, including upper and lower extremities and pulmonary embolism, received rivaroxaban 15 mg daily for 19 weeks until her pregnancy was discovered. Rivaroxaban was switched to enoxaparin for the remainder of the pregnancy. The baby was born spontaneously at 40 weeks gestation without complication, and no abnormalities were observed on any routine physical examinations or screenings up to 13 weeks of age. Although there are no clinical data in pregnancy with dabigatran, an in vitro pharmacokinetic placental transfer study observed a fetal/maternal ratio of 0.33 for dabigatran and 0.17 for the dabigatran etexilate mesylate prodrug after 3 hours, suggesting limited transfer of the prodrug across the placenta.25 The study authors recommended that dabigatran crosses the placenta to some extent and should not be used in pregnant women due to the risk of fetal coagulation abnormalities with in utero exposure.
The manufacturers of all NOACs state that it is unknown whether these agents are excreted in human milk.1-4 The apixaban manufacturer refers to 12% excretion of the maternal dose in the milk of lactating rats, but it is unclear whether this can be extrapolated to humans.1 No published reports of NOAC use in lactating patients were found.
Clinical experience with NOACs is fairly limited in special populations, including liver impairment, obesity, pregnancy, lactation, and pediatrics. Clinicians are urged to limit their use of these agents to clinical situations with published data supporting their efficacy and safety, which may include specific situations in special populations.
1. Eliquis [package insert]. Princeton, NJ: Bristol-Myers Squibb Company; 2014.
2. Savaysa [package insert]. Parsippany, NJ: Daiichi Sankyo, Inc; 2015.
3. Pradaxa [package insert]. Ridgefield, CT: Boehringer Ingelheim Pharmaceuticals, Inc; 2014.
4. Xarelto [package insert]. Titusville, NJ: Janssen Pharmacueticals, Inc; 2014.
5. Graff J, Harder S. Anticoagulant therapy with the oral direct factor Xa inhibitors rivaroxaban, apixaban and edoxaban and the thrombin inhibitor dabigatran etexilate in patients with hepatic impairment. Clin Pharmacokinet. 2013;52(4):243-254.
6. Potze W, Adelmeijer J, Lisman T. Decreased in vitro anticoagulant potency of rivaroxaban and apixaban in plasma from patients with cirrhosis. Hepatology. 2014. doi: 10.1002/hep.27350.
7. Martinez M, Tandra A, Vuppalanchi R. Treatment of acute portal vein thrombosis by nontraditional anticoagulation. Hepatology. 2014;60(1):425-426.
8. Intagliata NM, Maitland H, Northup PG, Caldwell SH. Treating thrombosis in cirrhosis patients with new oral agents: ready or not? Hepatology. 2015;61(2):738-739.
9. Caldeira D, Barra M, Santos AT, et al. Risk of drug-induced liver injury with the new oral anticoagulants: systematic review and meta-analysis. Heart. 2014;100(7):550-556.
10. Rochwerg B, Xenodemetropoulos T, Crowther M, Spyropoulos A. Dabigatran-induced acute hepatitis. Clin Appl Thromb Hemost. 2012;18(5):549-550.
12. Russmann S, Niedrig DF, Budmiger M, et al. Rivaroxaban postmarketing risk of liver injury. J Hepatol. 2014;61(2):293-300.
13. Liakoni E, Ratz Bravo AE, Terracciano L, Heim M, Krahenbuhl S. Symptomatic hepatocellular liver injury with hyperbilirubinemia in two patients treated with rivaroxaban.JAMA Intern Med. 2014;174(10):1683-1686.
14. Upreti VV, Wang J, Barrett YC, et al. Effect of extremes of body weight on the pharmacokinetics, pharmacodynamics, safety and tolerability of apixaban in healthy subjects.Br J Clin Pharmacol. 2013;76(6):908-916.
15. Breuer L, Ringwald J, Schwab S, Kohrmann M. Ischemic stroke in an obese patient receiving dabigatran. N Engl J Med. 2013;368(25):2440-2442.
16. Eriksson BI, Dahl OE, Feuring M, et al. Dabigatran is effective with a favourable safety profile in normal and overweight patients undergoing major orthopaedic surgery: a pooled analysis. Thromb Res. 2012;130(5):818-820.
17. Kubitza D, Becka M, Zuehlsdorf M, Mueck W. Body weight has limited influence on the safety, tolerability, pharmacokinetics, or pharmacodynamics of rivaroxaban (BAY 59-7939) in healthy subjects. J Clin Pharmacol. 2007;47(2):218-226.
18. Mahlmann A, Gehrisch S, Beyer-Westendorf J. Pharmacokinetics of rivaroxaban after bariatric surgery: a case report. J Thromb Thrombolysis. 2013;36(4):533-535.
19. Thomas Z, Bareket Y, Bennett W. Rivaroxaban use following bariatric surgery. J Thromb Thrombolysis. 2014;38(1):90-91.
20. Safouris A, Demulder A, Triantafyllou N, Tsivgoulis G. Rivaroxaban presents a better pharmacokinetic profile than dabigatran in an obese non-diabetic stroke patient. J Neurol Sci.2014;346(1-2):366-367.
21. Eriksson BI, Dahl OE, Rosencher N, et al. Dabigatran etexilate versus enoxaparin for prevention of venous thromboembolism after total hip replacement: a randomised, double-blind, non-inferiority trial. Lancet. 2007;370(9591):949-956.
22. Eriksson BI, Dahl OE, Rosencher N, et al. Oral dabigatran etexilate vs. subcutaneous enoxaparin for the prevention of venous thromboembolism after total knee replacement: the RE-MODEL randomized trial. J Thromb Haemost. 2007;5(11):2178-2185.
23. Eriksson BI, Dahl OE, Huo MH, et al. Oral dabigatran versus enoxaparin for thromboprophylaxis after primary total hip arthroplasty (RE-NOVATE II). A randomised, double-blind, non-inferiority trial. Thromb Haemost. 2011;105(4):721-729.
24. Konigsbrugge O, Langer M, Hayde M, Ay C, Pabinger I. Oral anticoagulation with rivaroxaban during pregnancy: a case report. Thromb Haemost. 2014;112(6):1323-1324.
25. Bapat P, Kedar R, Lubetsky A, et al. Transfer of dabigatran and dabigatran etexilate mesylate across the dually perfused human placenta. Obstet Gynecol. 2014;123(6):1256-1261.
26. Beyer-Westendorf J, Gehrisch S. Phamacokinetics of rivaroxaban in adolescents.Hamostaseologie. 2014;34(1):85-87.
27. Martinelli I, Bucciarelli P, Artoni A, et al. Anticoagulant treatment with rivaroxaban in severe protein S deficiency. Pediatrics. 2013;132(5):e1435-1439.
28. US National Institutes of Health. Clinicaltrials.gov website. https://clinicaltrials.gov/. Accessed February 13, 2015. | 2019-04-25T09:58:21 | https://pharmacy.uic.edu/departments/pharmacy-practice/centers-and-sections/drug-information-group/2014/2015-faqs/march-2015-faqs |
The market for online gambling acquisitions appears to be on another hot streak. After a record 2018 driven by an appetite for mobile gambling, buyers have continued to scoop up assets to bolster their mobile properties just as our data shows that mobile commerce is beginning to overtake other forms of digital commerce.
Paddy Power Betfair and 888 Holdings, both frequent shoppers in the space, have kept the party going into 2019, spending more than $175m so far on purchases of mobile gambling destinations such as Adjarabet, Jackpotjoy and BetBright. These early bets have put 2019 spending for online gambling targets on pace with 2018.
In all, investors put $6.1bn into online gambling properties in 2018, the highest-ever spending total for the sector, according to 451 Research’s M&A KnowledgeBase. The Stars Group’s $4.7bn play for Sky Betting & Gaming accounted for the bulk of last year’s total, while aligning with the trend that’s driven much of the M&A spending in this category – the push toward mobile gaming. In the case of Sky, mobile betting generated 80% of its revenue.
Of the 13 acquisitions of online gambling properties that took place in 2018, at least 11 featured targets that offer mobile applications for Android and iOS devices. According to 451 Research’s Global Digital Commerce Forecast 2018-2022, mobile app-enabled transactions are expected to surpass e-commerce transactions (i.e., transactions initiated on a laptop or desktop computer within a web browser) this year and will grow to 55% of all digital commerce transactions in 2022. | 2019-04-21T13:12:06 | https://blogs.the451group.com/techdeals/ma/gambling-on-the-go/ |
Low-level, data-driven core of boto 3.
A low-level interface to a growing number of Amazon Web Services. The botocore package is the foundation for the AWS CLI as well as boto3.
Documentation for botocore can be found here. | 2019-04-20T01:41:29 | https://pypi.org/project/botocore/ |
The shorts look to me like the Free Reign ones currently out. Or, maybe I should say that's how the Free Reign shorts looked on me when I tried them on!
I agree, they do look like Free Reigns to me, too.
i think that might be an ivivva outfit? i know they have a tumblin tank that looks just like that. power ys are way longer i think?
Ooh, good eye, anon@9:13pm! That is an Ivivva space dye grape seed/pretty purple white Tumbling Tank. The shorts look like they could be Ivivva Speedy shorts. | 2019-04-21T14:57:15 | http://www.luluaddict.com/2014/05/barely-pink-wee-are-from-space-power-y.html |
Which Path Are You On Anyway?
Are you stuck in the fog and just can’t seem to find your way out? If so, you’re not alone!
Most men these days are simply lost, overwhelmed, frustrated, sedated, and just beat up. We’ve lost our way, and so desperately want to find our way back.
Listen to Episode #16 – Which Path Are You On Anyway?
In this Episode, you’ll hear intimate stories of failure, pain and overcoming incredible odds from Epic Men Founders – Tom Terwilliger and Travis Greenlee. From bar fights, gun shots, bankruptcy, cancer and more… you’ll learn to cut through the fog and find your path to having it all.
Does your current path serve you?
What action steps do you need to take to clear the fog and get back into the game?
Spend some quality time really thinking about your current path.
Get feedback from people you respect, trust and care about; maybe a spouse, a coach, or member of the Epic Men Tribe.
Choose ONE Action Step based on your MOST IMPORTANT value and implement it immediately. | 2019-04-22T08:40:11 | http://epicmen.com/yourpath/ |
"General Motors Awards Scholarships to the University of Dayton"
New release announcing the three Dayton area graduates receiving scholarships paid for by General Motors to the University of Dayton.
"General Motors Awards Scholarships to the University of Dayton" (1955). News Releases. 8. | 2019-04-18T18:32:12 | https://ecommons.udayton.edu/news_rls/8/ |
In a RGB color space, hex #01b7c6 is composed of 0.4% red, 71.8% green and 77.6% blue. Whereas in a CMYK color space, it is composed of 99.5% cyan, 7.6% magenta, 0% yellow and 22.4% black. It has a hue angle of 184.6 degrees, a saturation of 99% and a lightness of 39%. #01b7c6 color hex could be obtained by blending #02ffff with #006f8d. Closest websafe color is: #00cccc.
● #01b7c6 color description : Strong cyan.
The hexadecimal color #01b7c6 has RGB values of R:1, G:183, B:198 and CMYK values of C:0.99, M:0.08, Y:0, K:0.22. Its decimal value is 112582.
Below, you can see some colors close to #01b7c6. Having a set of related colors can be useful if you need an inspirational alternative to your original color choice.
This text has a font color of #01b7c6.
This paragraph has a background color of #01b7c6.
This element has a border color of #01b7c6.
A tone is produced by adding gray to any pure hue. In this case, #5d696a is the less saturated color, while #01b7c6 is the most saturated one.
Below, you can see how #01b7c6 is perceived by people affected by a color vision deficiency. This can be useful if you need to ensure your color combinations are accessible to color-blind users. | 2019-04-26T08:27:12 | https://www.colorhexa.com/01b7c6 |
Welcome to the home page of Time Gone Amusements Pty. Ltd. We deal in amusement games and jukebox sales and hire.
Time Gone is an amusement games company in Sydney, Australia and has been in operation since 1972. We handle from the very oldest to the latest in video games, pinballs, pool tables, hockey tables, soccer tables, juke boxes and many other machines.
Forming and making an integral part of our operations has been party-hire. Over the years we have been actively engaged in hiring machines to numerous locations wherever it takes us.
You can ring to book for overnight, week end, and weekly hire and we will do the delivery and setup for you. Delivery within the Sydney Metropolitan Area is free.
Contact us 24 hours everyday of the week and our caring staff will be happy to provide answers to your questions. | 2019-04-26T06:33:36 | https://www.timegoneamusements.com.au/about/ |
The skirt in the women's wardrobe occupies a special place. It is she who creates the image of a feminine and refined beauty. In addition, the skirt is versatile - it is suitable for work, and for date, and for the theater.
In the new spring-summer season, a variety of silhouettes will be popular: a pencil, a trapeze, a bell, a straight skirt.
Of course, the most universal optionthere will be a pencil skirt. This model belongs to the eternal classic of the women's wardrobe, so it will never lose its relevance. In this spring-summer season, designers opted for the "pencil" of an elongated model with a high waistline. Many designers used wide contrasting belts as an additional color accent in combination with a pencil skirt.
If in your wardrobe there is still noa pencil skirt, then it's time to correct this misunderstanding. After all, in the spring-summer season of 2016, the pencil skirt will become one of the most popular models. About what exactly the style of "pencil" will be relevant and what to wear a fashionable pencil skirt this season will prompt our article.
The retro style also has not lost its popularity. In the spring of 2016, cessation returns us to the era of the 50's and 60's. So, on the catwalks you could see the models dressed in "bells", "sun" and "tulips".
As for the actual length, this seasondesigners do not restrict women in choosing suitable models. For example, the mini skirts that the young beauties love to wear are not out of fashion. Especially popular in the upcoming season will be a bright and checkered mini. Judging by the photos of the fashion collections, the midi-skirt is also very popular in the new season of 2016, which looks great in a monochrome color, mostly pastel and muted, classical tones. However, note that such skirts are better to wear with a thin strap that will emphasize your waist and balance the figure. In the trend of 2016 and skirts maxi. In particular, light long models will become a hit of the upcoming summer season.
Want to look stylish this spring, butworry about extra inches at the waist? Then by all means update your wardrobe of one of the fashionable skirts of this season! After all, designers in the spring-summer season of 2016 offer full women a huge selection of topical models and styles. Which ones? Learn from our article!
As for the color scheme of the fashionable skirts of the seasonspring-summer 2016, then designers use almost all colors and drawings. Especially fashionable shades were the classic colors: black, white, blue and gray. And from the bright ones you can distinguish the following colors: yellow, pink, red, red, blue and gold. The skirts with prints will become actual. In particular, the trend will be: floristics, geometry, cage, ethnic motives.
If we talk about fashionable skirts for business women,then the deserved championship at a skirt-pencil. Fashionable shades of this model will be: black, beige, brown, gray. And since the strict dress code implies a restrained color scheme, a perfect addition to the skirt of this cut will be a bright top. | 2019-04-20T08:41:24 | https://srathbun.com/fashion/6888-stilnye-yubki-2015-populyarnye-fasony-i-cveta-zhenskih-yubok-2015-goda-foto.html |
Effective and soft stain remover general cleaning product and carpet shampoo that can safely be used on all washable surfaces. Used for daily cleaning, cleaning of carpets, textiles, walls, glasses, floors, and as stain remover. Can be used for cleaning of offices, bathrooms, toilets, walls, floors and furniture.
Especially developed for current professional housekeepers’ needs.
J-3000 is an effective stain remover. It is multi-purpose. Very economical owing to substituting several products. Has a quite different chemical structure. Contained stain removers constitutes a complete synergy. It is effective for stains caused by coffee, tea, oil, ball pen, ink, drawing ink, nicotine and all fresh and raw food stuff. Especially developed for upholstery fabric and similar textile products. Does not leave residue on surface and textile, does not fade or decolorize them and prevent dirt desorption.
A general cleaning product containing eucalyptus oil and ammoniac developed to be used on hard surfaces. Thanks to containing natural eucalyptus oil and ammoniac it provides hygiene and you can feel freshness of cleaning in the ambient for a long time. LEIFI is also an effective spot & stain remover.
A general cleaning product developed to be used on hard surfaces. You can feel freshness of cleaning in the ambient for a long time.
Copyright @ 2012 | Bilim Kimya Ltd. Şti. | All rights reserved. | 2019-04-21T02:33:43 | http://iduna.com.tr/en/urunler/kategori/29/genel-temizlik |
Let 60' of RIVER FRONTAGE be your happy place! Newly built, five bedroom, 3 bath home with two garages; one 31 wide by 36 deep with 9 doors and one 36 wide by 38 deep with 8 doors! Elegant stucco home with stone accents and substantial lighting. Entry opens into great room with gas fireplace and built entertainment center, dining and gourmet kitchen with granite and upgraded, stainless appliances including 5 burner gas range. Beautiful windows throughout for natural light and appreciation of the tremendous river views. Downstairs includes two spacious bedrooms and full bath plus additional storage area and large laundry room. Upstairs has oversized bonus/game room with another rock accent fireplace, built in entertainment center and wet bar. Master suite enjoys the river views with walk in closet, jetted tub and tile lined shower. Upstairs also features another two bedrooms and full bath. Property is fully landscaped and fenced with covered patio as well as deck that cascades over the water for endless entertainment and enjoyment. Property across Dike Rd with bonus manufactured home transfers as well, measuring 60x485 (parcel 224-29054B and C). Schedule your private viewing today!
HOA Management Company Name: Colorado River Front Property Owners Assoc. | 2019-04-20T08:21:12 | https://www.kingmanhomesaz.com/riverfrontlake-properties-for-sale-in-mohave-county-az?display_action=details&mls_id=AZ-WARDEX&mls_no=951037&total_listings=23&lpp=20&display_page=2&index=1 |
Hi, welcome to 33dots.com. My name is Tony J Jose and I am a Computer Science student. I have a lot of interest in networking, security and system administration. I also do some web designing, and a bit of programming.
I believe in Free Software, Open source, standards based and accessible development.
33dots.com is an attempt to share the few bits of my experience with others. Mostly I’ll be posting about the things that I work on and the system issues that I face. I hope that this may be useful to someone. It will also help me remember how, why and when i did a particular thing.
Thanks for reading. Have a nice time!
This entry was posted in General and tagged 33dots on March 25, 2009 by tony. | 2019-04-18T22:31:24 | http://www.33dots.com/index.php/category/general |
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