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1Center for Human Immunobiology, Texas Children’s Hospital, Houston, Texas, USA.
3Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas, USA.
4Institute of Cellular Medicine, University of Newcastle, Newcastle upon Tyne, England, United Kingdom.
5Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, USA.
6Section of Experimental Haematology, Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, United Kingdom.
7Department of Clinical Immunology and Allergy, St James’s University Hospital, Leeds, United Kingdom.
8Division of Allergy and Immunology, Center for Cancer and Immunology Research, Children’s National Health System, Washington, DC, USA.
9Laboratory of Molecular Growth Regulation, Program in Genomics of Differentiation, National Institute of Child Health and Human Development, NIH, Bethesda, Maryland, USA.
10Department of Pediatrics, University of Pennsylvania School of Medicine, Children’s Hospital of Philadelphia Research Institute, Philadelphia, Pennsylvania, USA.
11Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA.
12Division of Hematopathology, Department of Pathology, The Ohio State University, Columbus, Ohio, USA.
13The Ohio State University Comprehensive Cancer Center, The James Cancer Hospital and Solove Research Center, Columbus, Ohio, USA.
14Laboratory of Clinical Infectious Diseases, NIAID, NIH, Bethesda, Maryland, USA.
15Department of Paediatric Immunology and Bone Marrow Transplantation, Great North Children’s Hospital, Newcastle upon Tyne, United Kingdom.
16Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, USA.
17Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, Texas, USA.
Address correspondence to: Jordan S. Orange, Center for Human Immunobiology, Baylor College of Medicine and Texas Children’s Hospital, FC330 1102 Bates Avenue, Houston, Texas 77030, USA. Phone: 832.824.1319; E-mail: [email protected].
J Clin Invest. 2017;127(1):306–320. https://doi.org/10.1172/JCI86276.
NK cell deficiency (NKD) is an inborn or primary immunodeficiency causing susceptibility to severe and often fatal viral infection and malignancy (1–5). NKD can be classified as classical, arising from profound or complete absence of the NK cell population or major subsets of peripheral NK cells, or functional, arising from impaired NK cell function with normal peripheral NK cell counts (5, 6). There are presently 2 genetically defined causes of classical (MCM4, GATA2) and 1 of functional NKD (FCGR3A) (2–4, 7–9).
Human NK cell development results in generation of distinct phenotypic and functional subsets found in peripheral blood: namely the CD56bright and CD56dim subsets. While identified primarily by the density of CD56 on the cell surface, these subsets include the coordinated expression of cell surface and intracellular markers that reflect each subset’s unique function. CD56bright NK cells are considered immunomodulatory and are described phenotypically as CD16−/loCD57−perforinlo, CD117+, CD62Lhi, and CD94/NKG2A+. While they constitute the minority of NK cells in peripheral blood, they represent the dominant population in secondary lymphoid tissue (10, 11). CD56dim NK cells, which constitute more than 90% of peripheral blood NKs, are CD56dimCD16hiperforinhiCD57+/− killer-cell immunoglobulin-like receptor+ (KIR+), and are the primary mediators of NK cell–mediated cytotoxicity. The relationship between the subsets is not completely understood, but both in vivo and ex vivo evidence in humans suggests that the CD56bright subset is a developmental precursor of CD56dim, and it is hypothesized that secondary lymphoid tissue serves as a site of NK cell terminal differentiation that is required for acquisition of cytotoxic function (12–15).
Specific loss of NK cells or NK cell subsets as occurs in classical NKD is rare but has been reported. Homozygous MCM4 mutation causes adrenal insufficiency, decreased numbers of circulating NK cells, and impaired terminal maturation, likely as a result of chromosomal aberrations and impaired proliferation of the CD56bright subset (2, 3). These patients show distinctive loss of the CD56dim subset and correlative relative increase in the CD56bright subset (2). In contrast, GATA2 mutations result in specific loss of CD56bright NK cells and decreased frequency of NK cells overall in circulating blood. While GATA2 patients have CD56dim NK cells that vary in number, they are largely nonfunctional, and affected patients develop severe herpesvirus and papillomavirus infections (4). NKD has also been reported in 1 isolated case of a child with a mutation in RTEL1, encoding regulator of telomere elongation helicase, although NK cell subsets were not examined in this case (16, 17).
Interferon regulatory factor 8 (IRF8; also known as interferon consensus binding protein, ICSBP) is a member of the IRF family of transcription factors that help shape the inflammatory response, particularly to viral infections. These transcription factors are also becoming increasingly recognized for their roles in human hematopoiesis through rare, naturally occurring germline mutations.
Mutations of IRF8 in mice and humans cause cellular deficiency ranging from severe defects of monocyte and DC production with marked myeloproliferation to more subtle alterations of specific DC subsets with normal leukocyte counts (18–20). Gene dosage and mutation site–specific effects have been observed, suggesting that the level of IRF8 activity is critical to normal immune cell development and function. In addition to developmental aberrations, mature cell function is affected as exemplified by defects in macrophage function (21). In humans, heterozygous IRF8 T80A mutations have been identified as a cause of primary immunodeficiency leading to specific loss of the CD11c+CD1c+ circulating DC subset (19). K108E mutations of IRF8 have an even more profound impact, leading to the loss of DCs as well as monocytes (19).
Before recent advances in genomic sequencing technology, NKD was reported in a number of pediatric cases. Perhaps the most renowned was an isolated case of NKD and viral susceptibility ultimately proven as resulting from a GATA2 mutation (4, 22). The original NKD case, however, was reported in 1982 as a familial, non–X-linked susceptibility to EBV infection that led to the death of 2 affected siblings and ongoing illness in a third (1). Here we report that biallelic mutations in IRF8 cause intrinsic NKD with decreased NK cell number, decreased frequency of the CD56dim subset, and accompanying susceptibility to viral and mycobacterial infection. In doing so we define and characterize IRF8 mutations in this original, unsolved family with NKD and identify NKD in 2 unrelated patients with biallelic IRF8 mutations. These data identify IRF8 as a critical regulator of NK cell terminal maturation and define a novel cause of a rare human inborn NK cell developmental defect.
Patients and clinical history. The index case proband (II.2) presented with a history of sinopulmonary infections during childhood and severe infectious mononucleosis at age 22 years requiring prolonged hospitalization (1). Born to non-consanguineous parents, his brother (II.6) died at age 16 years of multiple organ failure following severe EBV mononucleosis, and his sister (II.5) died at age 38 years due to progressive pulmonary disease. She also had prolonged hospitalization at age 17 years for severe EBV mononucleosis. Both siblings had lymphadenopathy and bronchiectasis beginning in childhood. Notably, the 3 siblings’ EBV-related illnesses occurred in separate calendar years. A fourth sibling (brother, II.3) had EBV mononucleosis at age 21 years at the same time as the proband, but had a typical course of illness and did not require hospitalization. The unusual nature of disease and clinical presentation in the proband prompted immunological evaluation and was described as a novel, non–X-linked immune deficiency leading to susceptibility to EBV disease associated with a deficiency of NK cell cytotoxicity (1). Since the original description, the patient has continued to have fairly regular, recurrent episodes of sinusitis and has mucosal changes consistent with recurrent and chronic disease as well as presumably respiratory viral infections. He has no evidence of bronchiectasis or lymphadenopathy. T cell and B cell counts have been consistently normal, and immunoglobulins are present in normal quantities and quality. His surviving brother (II.3), mother (I.1), children (III.1–3), and nephew (III.4) have unremarkable medical histories. Other unrelated patients are summarized in Table 1.
Genetics. The 1982 description of the proband’s family is without follow-up until now and did not include any genetic or genomic analysis. Thus, whole exome sequencing of genomic DNA was performed using blood samples collected from the proband; his son, mother, and surviving brother; and the son of the brother (Figure 1A). Excellent average per-base coverage was observed for all samples (proband, 105X; mother, 124X; brother, 116X; son, 114X; fraternal nephew, 90X). The exome data suggested disease-related segregation of mutations in IRF8 (NM_002163:c.602C>T, 39 variant reads of 112 total in the proband; NM_002163:c.671C>T, 44 variant of 72 total proband reads) predicted by conceptual translation to result in amino acid changes p.A201V and p.P224L, respectively. Of those mutations predicted to be damaging by SIFT, PolyPhen, LRT, and MutationTaster algorithms, few aside from IRF8 were expressed highly in immune cells, particularly NK cells (see Supplemental Table 1 for list of variants identified by whole exome sequencing; supplemental material available online with this article; doi:10.1172/JCI86276DS1). Sanger sequencing of IRF8 in the proband’s sons and daughter confirmed the presence of both alleles in his children and the absence of either variant in his wife (Figure 1B and Supplemental Figure 1). The P224L variant was present in his mother, and the A201V variant was present in a surviving brother. Therefore, IRF8 mutations were confirmed with familial segregation in accordance with Mendelian expectations. In addition, the P224L mutation was confirmed from paraffin-embedded tissue from the patient’s deceased sister (Supplemental Figure 1); degradation of the DNA extracted from the same sample did not permit amplification and sequencing of the A201V mutation. The P224L mutation is reported 5 times in the Exome Aggregation Consortium (ExAC) database (allelic frequency of 4.4 × 10–5) with no homozygous cases. The A201V mutation is present at an allelic frequency of 0.002515 with no homozygotes. Likewise, within the Baylor-Hopkins Center for Mendelian Genomics database of over 6,000 exomes, no homozygous or compound heterozygous cases of IRF8 variants are found (23). Both mutations map to exon 7, in the region of IRF8 known as the IRF association domain (Figure 1C).
Linkage analysis of IRF8 compound heterozygous mutations in familial NKD and genetic confirmation of mutation. (A) Pedigree of affected family. Roman numerals indicate generations. Arrow points to proband. Shown are amino acid variants in IRF8 as detected by whole exome sequencing. Asterisk indicates variant confirmed by Sanger sequencing. (B) Confirmation of proband’s IRF8 variants by Sanger sequencing. (C) Schematic of human IRF8 showing affected residues found within the IRF association domain. (D) Protein expression of IRF8 in EBV-transformed patient B cell line (maroon, solid line) relative to normal control (blue, dashed line). Isotype control is shown in black. Shown is 1 representative experiment from 3 independent repeats. (E) Western blot of IRF8 (48 kDa) in healthy donor (HD) or patient (Pt) lymphoblastoid cell lines with actin (42 kDa) as a loading control. Shown is 1 representative experiment from 3 independent repeats. (F) Nuclear localization of IRF8 in patient (Pt) or control (Ctrl) B cell lines or healthy donor NK cells. Cells were fixed and stained for IRF8 (eFluor 710, red) followed by counterstaining with DAPI (blue). Scale bar: 10 μm. Shown is 1 representative experiment from 3 independent repeats.
Evaluation of the patient’s protein expression by flow cytometry in lymphoblastoid cell lines showed normal levels of expression (Figure 1D), and Western blot analysis of IRF8 from patient EBV-transformed B cell lines confirmed protein expression at the expected molecular weight of full-length protein, as did healthy donor (Figure 1E; see complete unedited blots in the supplemental material). The only previously reported homozygous mutation in IRF8, K108E, was shown to impair nuclear translocation of IRF8 in transfected cells (21). To determine whether the novel compound heterozygous alleles found in our proband prevent the nuclear recruitment of IRF8, we evaluated the patient B cell line by imaging flow cytometry. In the absence of stimulation, IRF8 was detected in both the cytoplasm and the nucleus of patient and control B cell lines. This was also observed for healthy donor NK cells, with colocalization between DAPI and IRF8 as calculated by similarity score (24) of 3.4 for patient cells, 2.2 for control B cells, and 2.2 for primary human NK cells (median values) (Figure 1F). Stimulation with IL-15 did not increase localization of IRF8 in primary human NK cells (similarity score 2.2, not shown). Together these data confirm novel compound heterozygous mutations in IRF8 that do not abrogate protein expression or nuclear localization.
Biallelic IRF8 mutation leads to impaired NK cell cytotoxic function. To specifically test the effect of biallelic mutations on NK cell cytotoxicity, we performed standard 51Cr release assays. As previously described, the proband has consistently low NK cell functional activity against the prototypical K562 target (ref. 1 and Figure 2A). The proband’s cytotoxic function was evaluated multiple times during a 10-year time interval and consistently showed profoundly decreased activity relative to normal controls with specific lysis (at maximal effector-to-target ratio) that was 0% and 31% of normal control levels (Figure 2B). The patient’s children, carriers of the P224L or A201V mutations, had slightly decreased but normal cytotoxic function, as did his nephew and mother (Figure 2, A and C, and not shown). Unrelated carriers of the A201V mutation from a separate family of a different nationality similarly had normal NK cell cytotoxic function (Figure 2C), despite having late onset of pulmonary nontuberculous mycobacterial disease (Table 1). Other heterozygous patients (G139S/WT, A179/WT, T96M/WT) also had normal NK cell function despite the presence of pulmonary nontuberculous mycobacterial infection (Figure 2C and Table 1). To determine whether decreased NK cell lytic function in the proband was due to low NK cell frequency within the lymphocyte population, cytotoxicity assays using purified NK cells were performed, and showed significantly decreased lysis of targets (Figure 2D), suggesting that an intrinsic defect in NK cell cytotoxic function underlies the stably decreased impairment observed. Therefore, the compound heterozygous A201V/P224L mutation results in low/absent NK cell cytotoxic function, an effect that is repeatedly observed over extended time and likely accounts for the proband’s profound susceptibility to viral disease.
NK cell functional deficiency specifically occurs in IRF8 compound-heterozygous patient and is stable over time. NK cell cytotoxicity was evaluated by standard 51Cr release assay against K562 targets. (A) Shown is a representative assay including our proband (A201V/P224L), his healthy brother (A201V/WT), and his healthy son (P224L/WT). The gray filled area represents the range of 10 healthy donors. ***P < 0.0001, Student’s unpaired t test against mean of all healthy donors. Patient data are representative of 6 independent repeats. (B) The proband’s NKD is stable over time as assessed by 51Cr release assay against K562 targets. Shown is relative specific lysis by patient NK cells at the highest effector-to-target ratio (dashed line, circles) compared with corresponding healthy donor control (solid line, squares) at dates from 2004 to 2012 (x axis). (C) 51Cr release assay of unrelated A201V/WT (daughter of proband or unrelated as indicated), P224L/WT (son of proband), G139S/WT, A179V/WT, and T96M/WT patients (circles). The gray filled area represents the range of 10 normal donors. Each condition was performed in triplicate and is shown as the mean. (D) 51Cr release assay of freshly isolated purified patient (circles) and healthy donor (squares) NK cells against K562 target cells. Shown is 1 representative of 2 independent experiments with each condition performed in triplicate.
Biallelic IRF8 mutation results in decreased NK cell number and impaired NK cell terminal differentiation. We next functionally examined NK cells from probands with 2 different combinations of compound heterozygous and a homozygous (i.e., biallelic) variant allele: A201V/P224L, R83C/R291Q, and homozygous K108E. Human NK cells in peripheral blood fall largely within 2 dominant subsets with unique phenotypic and functional signatures. High density of CD56 and the presence of CD94/NKG2A, CD117, and CD62L on the cell surface classify the CD56bright subset phenotypically. These cells are considered the most potent cytokine producers upon stimulation, primarily of TNF-α and IFN-γ. The CD56dim subset is characterized by markers of terminal differentiation such as CD57, activating and inhibitory KIRs, and CD16, and is thought to be derived from the CD56bright subset (13). In addition, CD56dim NK cells express large quantities of perforin and granzymes; they are specialized for contact-mediated target cell lysis.
Consistently over the time of evaluation (>10 years) the patient had decreased frequency and absolute number of CD56+CD3− NK cells within the lymphocyte population (1.7%–6.0% vs. 4.6%–13.7% in healthy controls) (Figure 3, A–C, and Table 1). Evaluation of the phenotypic subsets within peripheral blood showed a relative paucity of the CD56dim subset in the patient, accompanied by an overrepresentation of the CD56bright subset. From our initial evaluation in 2004 and at all subsequent times evaluated, patient 1’s CD56bright subset was between 30% and 40% (27.9%–40.3%) of the NK cell population, in contrast to controls, which fell within the previously described range (4.1%–8.4%) (Figure 3, A–C, and ref. 25). Evaluation of heterozygous A201V/WT subjects (both unrelated and related) showed normal frequencies of both NK cells within the peripheral blood mononuclear cell (PBMC) population (13.9%) and CD56bright NK cells (3.7%). Further, evaluation of other heterozygous individuals (T96M/WT, G139S/WT, A179V/WT) showed frequencies of NK cells and CD56bright NK cells consistent with normal controls (Figure 3, B–D). In contrast, the R83C/R291Q and the homozygous K108E patient had low overall numbers of NK cells (3.9% and 5.4%, respectively) and a significantly expanded CD56bright population consistent with our proband (65.8% and 72.7%; Figure 3, B–D). Therefore, compound heterozygous or homozygous mutations in IRF8 selectively result in aberrant generation of the terminally mature subsets of NK cells and a decreased frequency of NK cells within the lymphocyte population.
Stable impairment in NK cell terminal differentiation in patients with biallelic IRF8 mutations. NK cell phenotype was evaluated by multiparametric FACS phenotyping. (A) Representative FACS plot of healthy donor control (WT/WT) and our proband (A201V/P224L). Lymphocytes were gated on FSC/SSC. Data shown are representative of 6 independent repeats. (B) Stable NKD (left) and increased CD56bright population (right) in our proband shown over time (dashed line) with healthy donor shown as reference (solid line) at multiple dates from 2004 to 2015 (x axis). Single time point analysis of A201V/WT (unrelated, open diamond), A179V/WT (open triangle), an unrelated R83C/R291Q compound-heterozygous patient (solid inverted triangle), and a K108E/K108E patient (solid diamond) is also shown. (C) Percentage of CD56+CD3− NK cells within the lymphocyte gate is shown for 4 normal controls, our proband at 4 independent time points, 3 unrelated heterozygous IRF8 mutation patients, an unrelated compound-heterozygous patient, and a K108E/K108E patient. (D) Percentage of CD56bright NK cells within the NK cell compartment is shown for the cohort described in C. (E) FACS phenotyping of heterozygous, compound-heterozygous, and homozygous IRF8 patients. For intracellular staining, mononuclear cells were stimulated (S) with PMA and ionomycin in the presence of brefeldin A or incubated without stimulation (U) before fixation, permeabilization, and detection of intracellular effector molecules. (F) Expression of IFN-γ (after PMA/ionomycin stimulation) and perforin and CD16 in unstimulated NK cells from patients and healthy donors gated on CD56dim and CD56bright subsets. Shown is mean ± SD of 3 independent experiments for perforin and CD16 in healthy donor and A201V/P224L patient; a single experiment is shown for the K108E/K108E patient and IFN-γ detection from all subjects. *P < 0.05 by unpaired Student’s t test. (G) Cytokine secretion from healthy donor (HD) or A201V/P224L patient (Pt) detected by cytokine bead array from PBMCs stimulated for 4 hours by nonautologous EBV-transformed B cells in lytic cycle.
Because of the patient’s consistently low NK cell cytotoxic function and abnormal NK cell subset distribution, we performed multiparametric flow cytometric immune phenotyping of NK cell subsets, including intracellular cytokines IFN-γ and TNF-α as well as perforin and granzymes. We evaluated the patient, his clinically unaffected single-heterozygous family members, an unrelated heterozygous A201V/WT patient with pulmonary nontuberculous mycobacterial infection, a heterozygous T96M/WT patient, an unrelated compound-heterozygous patient (R83C/R291Q), and a homozygous K108E patient (Table 1).
Multiparametric flow cytometric analysis of the proband’s lymphocytes showed that NK cell markers were consistent with the expanded CD56bright subset but otherwise showed no aberrant expression of markers of activation, inhibition, or granzyme B (Figure 3E). Despite decreased representation of the CD56dim subset, markers of NK cell terminal differentiation and memory (CD57, NKG2C) were expressed, as were activating receptors (NKG2D) and inhibitory receptors (NKG2A). Interestingly, however, our proband had consistently low levels of perforin at multiple time points tested, as did the homozygous K108E patient (Figure 3E). Upon stimulation, the proband, as well as those patients with compound heterozygous variants in IRF8, expressed normal or higher than normal levels of IFN-γ and TNF-α measured both as percentage of the population expressing cytokine and on a per-cell basis (Figure 3E and not shown). The production of IFN-γ was comparable between patient and control CD56bright NK cells, which are generally the most potent producers of IFN; however, the patient CD56dim NK cells had increased IFN-γ production relative to control. This accounted for the increase in IFN-γ production in his NK cells when considered as a total population (Figure 3F). The patient with K108E/K108E mutations had impaired IFN-γ production upon stimulation from both NK cell subsets, potentially underscoring the different effects of the different mutations on immune function even in the context of similar NK cell phenotype. The observed decrease in perforin expression in our patient with A201V/P224L mutations and the patient with homozygous K108E mutations was confined to the CD56dim subset, the primary cytolytic effectors. CD16 (FcγRIIIA) was expressed at normal levels on CD56bright and CD56dim NK cells from the patients with A201V/P224L and R83C/R291Q mutations (Figure 3, E and F). Low expression of CD16 on NK cells from the K108E patient was restricted to the CD56dim NK cell subset (Figure 3F).
Given the important role that cytokine production plays in the control of the viral immune response and previously described DC deficiency in patients with IRF8 mutations, we sought to determine whether cytokine production in the context of costimulation by accessory cells was impaired in our patient. To do so, we incubated PBMCs from healthy donor or patient with a nonautologous EBV-transformed B cell line that had been induced to lytic cycle. Secreted cytokines (IL-12p40, IFN-γ, TNF-α, and IL-10) were measured by flow cytometric bead array. As suggested by the intracellular flow cytometry data, the coculture-induced production of IFN-γ and TNF-α was not impaired in the patient, and, similarly to that observed in cytokine-stimulated NK cells, the production of IFN-γ in these cocultures was increased (Figure 3G). Interestingly, elevated secretion of both IL-12 and IL-10 was also observed from patient cells.
As IRF8 serves a previously identified role in DC development and IRF8 deficiency has been shown to lead to a variable loss or absence of DC subsets, we performed phenotypic analysis of monocyte and DC populations. A subtle deficiency of plasmacytoid dendritic cell (pDCs) and CD141+ DCs was observed in the index patient relative to heterozygous family members and a wild-type control (Supplemental Figure 2). These differences were within the scope of those previously ascribed to human IRF8 mutations and were not as severe as those observed in the patient with homozygous K108E mutation (19).
Our findings, however, suggested a novel NK cell phenotype of arrested terminal maturation in the presence of biallelic IRF8 mutations. To further determine the role of IRF8 in NK cell maturation, we performed phenotypic analysis of NK cells from Irf8–/–, Irf8+/–, and Irf8+/+ mice by flow cytometry. While murine NK cells do not express CD56, and not all transcription factor functions are evolutionarily conserved between human and murine NK cells, the developmental stages of murine NK cells can be stratified according to expression of CD27 and CD11b (Mac-1) (26). As previously reported (27–29), Irf8–/– mice had significant splenomegaly and lymphocytosis, leading to increased absolute NK cell number in both spleen (14 × 106 ± 5.7 × 106) and blood (1.2 × 106 ± 0.7 × 106) relative to that of Irf8+/+ controls (spleen 2.5 × 106 ± 1.2 × 106, blood 0.89 × 106 ± 0.6 × 106). Despite this, as seen in Figure 4, NK cells from blood and spleen of Irf8–/–, but not Irf8+/–, mice had an increased frequency of immature Mac-1loCD27hi NK cells (22.5% ± 2.7%) within the NK cell population when compared with wild-type controls (9.7% ± 1.8%). This was also reflected by absolute numbers of these subsets (blood 0.45 × 106 ± 0.4 × 106, spleen 3.6 × 106 ± 1.9 × 106) when compared with wild-type controls (blood 0.36 × 106 ± 0.5 × 106, spleen 0.31 × 106 ± 0.3 × 106). Conversely, Irf8–/– mice had decreased frequency of mature Mac-1hiCD27lo NK cells (48.3% ± 3.9%) compared with wild-type controls (64.3% ± 3.9%). This was despite increased absolute cell number (blood 1 × 106 ± 0.6 × 106, spleen 5.7 × 106 ± 2.1 × 106) compared with controls (blood 0.7 × 106 ± 0.5 × 106, spleen 1.4 × 106 ± 0.6 × 106). Together, these demonstrate impairment in terminal maturation in mice with homozygous, but not heterozygous, Irf8 loss-of-function mutations, suggesting an important parallel to our patients with biallelic IRF8 mutations and increased frequency of immature NK cells.
Irf8–/– mice have a block in terminal NK cell maturation. Spleen and blood from Irf8–/–, Irf8+/– littermates, and Irf8+/+ controls were analyzed by flow cytometry for markers of NK cell differentiation. (A) Representative FACS of spleen (top) and blood (bottom) from the same mouse. Cells were gated on single cells, then NK1.1+CD3−. (B) Pooled spleen and blood from 4–6 mice per condition are shown. Data shown are mean ± SD. *P < 0.05 by Student’s unpaired t test.
IRF8 is required for human NK cell development in a cell-intrinsic manner. Given the broad expression of IRF8 within immune cell populations, we sought to determine whether the observed effect on NK cell function was due to NK cell–intrinsic mechanisms or representative of the need for other immune or nonimmune cell types in NK cell development. Thus, we evaluated the ability of patient CD34+ hematopoietic stem cells (HSCs) to generate NK cells in isolation. HSCs were sorted from our proband’s peripheral blood and incubated on OP9-DL1 stromal cells for 28 days in the presence of IL-7, FLT3L, c-Kit, and IL-15, as this in vitro experimental system has been previously demonstrated to promote NK cell development (14, 30, 31). As shown in Figure 5A, patient NK cells derived from CD34+ HSCs were largely CD56bright (76% vs. 19.7% from healthy donor control). The mean fluorescence intensity of CD56 was significantly higher on patient cells versus the normal control (224 vs. 112 in healthy donor) (Figure 5B), consistent with immaturity and incomplete maturation. In addition, while healthy donor–derived cells acquired CD16 (58%), the patient-derived cells had decreased CD16 expression yet retained CD94, a phenotype that is reflective of an immature state. These results show that the role for IRF8 is cell intrinsic and that IRF8 is functioning directly in the generation of appropriate and mature NK cell subsets during development.
Impairment in terminal NK cell differentiation is NK cell intrinsic. CD34+ hematopoietic stem cells were sorted from the proband and a healthy control, and NK cells were generated by coculture with OP9-DL1 stromal cells for 35 days. Cells were harvested and analyzed in parallel with freshly isolated PBMCs from the proband or the same healthy donor. (A) In vitro–generated NK cells from healthy donor (left, WT/WT) or our proband (right, A201V/P224L) were analyzed by FACS for CD56 expression and CD16 (top) and CD94 (bottom) expression. (B) Histogram showing mean fluorescence intensity of CD56 expression on in vitro–derived NK cells from healthy donor (gray histogram) or patient 1 (empty histogram).
IRF8 is expressed in human NK cell subsets and is upregulated upon IL-15 stimulation. Expression of IRF8 in human NK cell developmental subsets has not been previously determined. We performed real-time PCR and intracellular flow cytometry to evaluate the expression of IRF8 in human NK cell developmental subsets. While human peripheral blood contains only the CD56bright and CD56dim NK cell subsets, we used human tonsil as a source of developing NK cells and evaluated these cells based on known markers of differentiation (stages 1–5) (32). As shown in Figure 6A, healthy human donors expressed IRF8 in all developmental subsets as measured by intracellular flow cytometry. Interestingly, expression was highest in stage 1 (CD34+) NK cell precursors; however, all developmental subsets isolated from tonsil, as well as those from peripheral blood, expressed significant quantities of IRF8. Further, stimulation of primary human NK cells with IL-15 for as few as 6 hours resulted in an upregulation of IRF8 as measured by quantitative PCR (qPCR) (3-fold; Figure 6B) and flow cytometry (1.3-fold; Figure 6, C and D). Therefore, IRF8 is expressed in human NK cells and is responsive to IL-15 stimulation. This observation is consistent with a critical role for IRF8 during NK cell development.
IRF8 is expressed in all NK cell developmental subsets and is upregulated upon IL-15 stimulation. (A) NK cell developmental subsets were isolated from tonsil as described in Methods, and IRF8 was detected by intracellular flow cytometry. Shown is 1 representative experiment from 3 independent experiments from 3 normal donors. FMO, fluorescence minus one; PB, peripheral blood. (B) NK cells were incubated for 6 hours with 10 ng/ml of IL-15 or vehicle control, and then RNA was extracted and qPCR performed as described in Methods. ***P < 0.001 by Student’s t test. Shown are the means of 3 independent experiments performed on 3 donors, each done in quadruplicate. (C) NK cells were stimulated as in B and subjected to flow cytometric analysis as in A. Dashed line, IL-15 stimulated; solid line dark histogram, unstimulated; solid line light histogram unstained. (D) Shown is the mean ± SD of 3 independent experiments. *P < 0.05 by unpaired Student’s t test. MFI, mean fluorescence intensity.
IRF8 is required for NK cell expression of transcription factors and NK cell effector molecules. Previously reported homozygous K108E mutations in IRF8 lead to impaired synthesis of IL-12 due to abrogated IRF1-dependent transcription of the IL12B gene (19). To determine whether the mutations in our proband affected functional binding of IRF8 with cofactors IRF1 and PU.1, we performed luciferase assays with each allelic variant (WT, A201V, and P224L). As seen in Figure 7A, neither of our patient’s variants affected transcriptional activity dependent on PU.1 or IRF1. This is consistent with the observation that DC development was only partially affected in the patient and contrasts with biallelic K108E mutation, in which transactivation with IRF1 was severely impaired and monocytes and DCs were absent (19). Collectively, this underscores the variability of mutational impact on the DC phenotype. To determine the effect that the IRF8 mutations have on human NK cell function, we performed NanoString gene expression analysis (Human Immunology v2 gene set) on isolated NK cells from our proband, his family members, and 3 healthy donor controls. We identified 403 genes with a greater than 1.5-fold up- or downregulation in the patient relative to all 3 healthy donors (Supplemental Table 2). These included 18 of particular relevance to NK cell development, cytotoxicity, or homeostasis (Figure 7B), including transcription factors NFIL3, IKZF2, TBX21, EOMES, and STAT5A/B. Differentially expressed effector molecules and cell surface receptors included PRF1, GZMA, GZMB, CCR7, CD27, CD2, HAVCR2, and KLRG1. Ingenuity Pathway Analysis of all genes differentially up- or downregulated more than 5-fold revealed transcription factors, growth factors, kinases, and transmembrane receptors (Figure 7C). To provide additional evidence that the genes differentially expressed in NK cells might be direct transcriptional targets of the mutant IRF8 proteins, we compared genes that consistently had an absolute fold change of ≥2 with published ChIP sequencing data (33). This analysis revealed a significant overlap of differentially expressed genes with loci associated with 1 or more IRF8 peaks (Supplemental Table 3). There was no preferential association of up- or downregulated transcripts with the presence of IRF8 binding. To further biologically validate differential expression of potential direct targets, we focused on NFIL3 and PRDM1, where IRF8 binding was observed in the study by Langlais et al. (33) (Supplemental Table 3), and IRF4, which also has evidence of IRF8 binding by ChIP sequencing (34). We performed qPCR on healthy donor– or patient-derived B cell lines and found decreased expression of each in the patient relative to 3 healthy donors (Figure 7D). Re-expression of WT IRF8 protein in the patient B cell line rescued the expression of IRF4 and PRDM1 and partially rescued expression of NFIL3. Therefore, biallelic IRF8 deficiency results in decreased expression of human NK cell transcriptional regulators and effector molecules as well as genes not previously associated with NK cell regulation. Complementation of the patient B cell line with WT IRF8 restores expression of these, demonstrating a direct effect of compound heterozygous A201V/P224L mutations on the expected IRF8-mediated gene expression profile.
Deregulation of multiple genes in A201V/P224L IRF8 patient NK cells. (A) Promoter assays were performed in HeLa cells with WT or mutant alleles as indicated. Mutant and WT IRF8 showed indistinguishable regulation of PU.1- and IRF1-dependent genes. Results are displayed as fold increase relative to cells cotransfected with the empty vector. These data are derived from triplicate samples and are displayed as the mean ± SD. Data were analyzed using Student’s unpaired t test (**P < 0.01, ***P < 0.001). (B) Selected NK cell genes up- or downregulated in IRF8 A201V/P224L patient and heterozygous family members identified by NanoString gene expression analysis. (C) Selected immune genes classified by Ingenuity Pathway Analysis that are up- or downregulated more than 3-fold in the A201V/P224L patient relative to all 3 healthy donors (total NK cells). (D) Expression of selected genes validated by qPCR of B cell lines from 2 healthy donors (HD), patient (Pt), or patient cells stably transfected with WT IRF8 (Pt+IRF8). Mean ± SD of 1 representative experiment of 4 (performed in quadruplicate) is shown normalized to the mean of HD. *P < 0.05, ***P < 0.0001 by ordinary 1-way ANOVA with Tukey’s multiple comparisons.
Genetic causes of aberrations in NK cell development are exceedingly rare but confer familial susceptibility to disease, particularly viral infection. Here we identify a novel human NK cell developmental defect and cause of NKD due to biallelic mutation in the IRF8 gene. Interestingly, while homozygous and heterozygous IRF8 mutations lead to a spectrum of DC deficiency ranging from mild to severe, biallelic variants in our patient and 2 additional unrelated patients result in NKD as a result of a block in terminal maturation. In our patient this phenotype occurs in the context of normal activation of PU.1 and IRF1, underscoring the varying impact of IRF8 mutations.
Our proband was originally diagnosed in 1980 and reported in 1982 with the first case of non–X-linked susceptibility to EBV as a result of NKD (1), and as such is within the first reported cohort of patients with NKD. Having the unique opportunity to study the 1 surviving affected patient from this family longitudinally has underscored the stability of the NK cell phenotype, namely decreased NK cell number with a paucity of CD56dim NK cells and interrupted maturation.
The IRF family plays a well-documented role in inflammation, and these transcription factors are also becoming increasingly recognized for their importance in hematopoietic development (35, 36). In particular, a critical requirement for IRF8 in DC development is described in mice with both hypomorphic and knockout mutations of IRF8, as well as previously described patients with heterozygous and homozygous mutations (19). Patients with homozygous K108E mutation are close in phenotype to the knockout mouse, with severe deficits of monocytes and DCs and a myeloproliferative disorder (29, 37–39). This homozygous mutation in the DNA-binding domain of IRF8 abrogates nuclear translocation but not protein expression, leading to impaired function and defective IL-12, IFN-γ, and TNF-α production (21). In contrast, the spontaneous heterozygous T80A mutation leads to specific loss of the CD1c+ compartment of CD11c+ DCs but retention of CD141+ DCs, monocytes, and CD123+ plasmacytoid DCs (19). Relative to disease caused by autosomal recessive K108E mutation, the T80A heterozygous mutation leads to a less severe clinical course. IL-12 production, but not type I IFN, is affected. In both cases, both B and T cell numbers are largely normal; however, CD25hiFoxP3+ Treg numbers are decreased in patients with K108E mutation (39).
The mechanism for the differential impact of IRF8 mutations on DC and NK cell homeostasis remains unclear. Gene dosage and mutation site–specific effects are commonly observed in transcriptions factors such as IRF8 that are regulated by superenhancer structures (40). As opposed to A201V/P224L, the K108E mutation is unable to activate IRF1- and PU.1-dependent transcription and, in the biallelic state, is associated with monocyte and DC deficiency and a very marked distortion of NK cell development in the ratio of CD56bright to CD56dim cells. The patient described here with A201V/P224L mutation has an NK phenotype with only subtle DC deficiency, in keeping with the ability of the 2 variants to activate transcription with PU.1 and IRF1. As these processes are required for DC development and function, these data suggest that additional IRF8-dependent mechanisms are required for normal NK cell homeostasis.
While all of our patient’s surviving single-heterozygous family members have unremarkable medical history, an unrelated patient with heterozygous A201V/WT mutation of IRF8 and late-onset pulmonary nontuberculous mycobacterial infection was identified, although a role for this IRF8 change in her disease state is unclear. The late onset of disease in an unrelated patient with A201V mutation suggests the relatively mild impact of this variant and that careful monitoring of heretofore clinically unaffected heterozygous family members may be prudent.
The apparent requirement for IRF8 in an NK cell–intrinsic manner, as we show using in vitro differentiation experiments, points to a direct role in the generation of appropriately distributed CD56bright and CD56dim NK cells and the subsequent acquisition of effector function. As with GATA2 mutations, it is intriguing that perturbation of development that allows for the presence of CD56dim NK cells in peripheral blood nevertheless significantly affects the function of these cells. The profound disease in our patient and the consistent absence of NK cell cytotoxic function as a result of this developmental block speak to the strict regulation of this process and support a model in which CD56bright cells are the precursors of CD56dim. The impaired terminal maturation of NK cells from Irf8–/–, but not Irf8+/–, mice suggests a conserved requirement for IRF8 in the final stages of NK cell development and supports a linear relationship between the subsets. As with GATA2 mutations, CD56+CD3+ T cells are present in our patient, often at higher frequencies than in normal controls.
IRF8 is known to play a role in both cell fate decision and functional control of viral infection. IRFs are well-described downstream mediators of TLR signaling, and IRF8 mediates TLR9 signaling through TRAF6 and NF-κB (41, 42). Production of IFN-γ and TNF-α was normal in our patient in NK cells stimulated by PMA/ionomycin or EBV-transformed B cells, suggesting that disruption of cytokine production was not the primary mechanism of viral susceptibility in our patient. Elevated levels of IFN-γ (both intracellular and secreted in response to stimuli) were measured from our patient at multiple times of assessment. While the clinical significance of this is unclear, it may be related to PRDM1 downregulation (detected by gene expression array and qPCR of patient B cell lines), as PRDM1 has been previously shown to directly bind and negatively regulate the IFN-γ locus in human NK cells (43). In contrast, as previously reported in PBMCs (19), K108E/K108E NK cells did not produce IFN-γ in response to stimulation, suggesting that the differential effect of the mutations on IRF1 activation may include differing effects on IFN-γ production in NK cells. In primary NK cells or NK-92 cell lines, cytokine stimulation increases levels of nuclear IRF8 and increased binding to DNA (43, 44). In CD8+ T cells, common γ chain signaling in combination with CD3 cross-linking results in increased IRF8 expression in concert with JAK/STAT signaling and leads to differentiation of CD8+ effectors from naive precursors. Deletion of IRF8 results in decreased, but not absent, T lymphocyte cytotoxicity, and it is hypothesized that presentation of γc cytokine, namely IL-15, in combination with antigen by neighboring DCs could drive CD8+ differentiation (45). IL-15 is unique among cytokines in its absolute requirement for NK cell development and homeostasis in both mice and humans (46, 47). Therefore, the positioning of IRF8 in this critical signaling pathway speaks to its importance in generating mature, functional human NK cells, and the significant downregulation of JAK3 and STAT5A and -B in our patient relative to 3 healthy donors supports this hypothesis.
While we show that the NK cell developmental defect is intrinsic, an additional model for the requirement of IRF8 in NK cell development and function would be through the trans-presentation of IL-15 by DCs, which would potentially make the loss of DCs and functional defect of NK cells in IRF8 patients particularly damaging. Our data support a link between IL-15, IRF8, and NK cell development, as we show that IL-15 increases IRF8 protein expression in as few as 6 hours in ex vivo NK cells. This observation suggests a need for the IL-15–induced proliferation of CD56bright NK cells in the generation of the CD56dim subset, as proposed in the report of MCM4 deficiency, the only other reported immune deficiency to result in this distinctive NK cell phenotype (2). This concept was originally proposed by Lutz et al. after they showed that CD56bright NK cells undergo significantly greater proliferation than the CD56dim subset (48). In addition, FLT3L-mediated development of DCs is dependent on IRF8 signaling, and FLT3L-deficient mice have decreased NK cell number and impaired NK cell development (49). Therefore, our data could suggest a similar requirement for IRF8 in FLT3L-mediated signaling in NK cells.
While a direct role for IRF8 in NK cell development has not been described, IRF2-deficient mice have reduced NK cell number and, as a result, impaired NK cell cytotoxic function (50, 51). Further, IRF2-deficient bone marrow is enriched for immature NK cells (selective loss of the CD11bhiDX5hi subset) with higher rates of apoptosis and decreased sensitivity to IL-15, a defect that is cell intrinsic (51). Whether the loss of CD56dim NK cells in IRF8 deficiency is a result of accelerated apoptosis of this subset, as is the case for IRF2 mice, or a result of impairment in the transition from CD56bright to CD56dim, remains to be seen. While IRF1-deficient mice also have decreased NK cell number and function, IRF1 is required for IL-15 production by bone marrow stromal cells, and the NKD in these mice is due to the loss of IL-15 in the niche (52).
IRF8 plays a role in lineage commitment, particularly of DCs and B cells, and can substitute for the highly related factor IRF4 in some circumstances (18, 40, 53, 54). Both IRF4 and IRF8 have the capacity to act as either transcriptional activators or repressors but require other lineage-specific transcription factors as binding partners to achieve the appropriate outcome. For example, IRF4/IRF8 can interact with PU.1 or SPI-B at cis-regulatory regions termed Ets-IRF composite elements (EICEs) in B cells, DCs, and macrophages. While PU.1 is not required for NK cell development, PU.1-deficient NK cells in mice showed reduced proliferation both at baseline and in response to IL-12 and IL-2 (55). However, PU.1 is difficult to detect in mature NK cells and is hypothesized to be required exclusively for lineage commitment (56). While EICEs are fairly well characterized, genetic approaches in T cells and DCs have recently revealed novel motifs recognized by IRF4/IRF8, such as AP-1–IRF composite elements bound by BATF-IRF complexes (57, 58). Given the normal regulation of PU.1 and IRF1 elements by our patient’s IRF8 variants, work is currently underway to identify novel binding partners of IRF8 in NK cells.
Recent high-resolution analysis of the ontology of both mouse and human ILC and NK cell lineages shows IRF8 highly expressed specifically in NK cells and, in the case of human cells, intraepithelial ILC1s (59, 60). Our gene expression analysis of purified NK cells suggests that IRF8 plays a direct role in the regulation of NK cell genes required for maturation and function of human NK cells. These include NFIL3 (encoding E4BP4), PRDM1 (encoding BLIMP-1), TBX21 (encoding T-bet), and IKZF2 (encoding HELIOS), all previously shown to be required for mature NK cell generation and/or homeostasis (43, 61–66). E4bp4–/– mice fail to generate even immature NK cell precursors, indicating a very early blockade in development, and E4BP4 is considered a master regulator of NK cell fate (61, 64, 65). The previously demonstrated gene dosage effect of E4BP4 suggests that repression but not absence of NFIL3, as seen in our patient, may lead to decreased mature NK cell numbers while not completely abrogating development (61), and placing NFIL3 downstream of IRF8 would be consistent with previous reports showing normal IRF8 expression in Nfil3–/– mice (67). Similarly, Tbx21–/– mice fail to generate mature NK cells and T-bet expression increases with NK cell maturation, with T-bet highly expressed in the CD56dim NK cell subset (62, 68). Both PRDM1 and HELIOS tune NK cell responsiveness; PRDM1 is a transcriptional repressor that binds directly to TNF and IFNG loci to regulate cytokine secretion in human NK cells (43) and is bound directly by IRF8 in B cells and macrophages (34), whereas HELIOS regulation is a mechanism of modulation of NK cell activity mediated through NKp46 ligation (69). Finally, the NK cell defect observed in our patient may be attributable to the significant downregulation of STAT5a and STAT5b, in concert with JAK3 and perforin. This signaling axis has been shown to be critical for NK cell survival and function, and STAT5b regulates NK cell cytolytic activity by binding directly to the perforin promoter (70, 71). Collectively, our data suggest that IRF8 may be playing a role in both NK cell lineage commitment and effector responses, which is in keeping with the functional and developmental defects observed in NK cells from patients with biallelic IRF8 mutations.
In summary, we have defined a novel NKD and primary immunodeficiency that occurs specifically as a result of biallelic mutations in IRF8 encoding the transcription factor IRF8. These alterations result in impaired NK cell function, decreased NK cell number, and loss of the CD56dim subset of human NK cells, reflecting impaired NK cell terminal maturation also observed in Irf8–/–, but not Irf8+/–, mice. Immunodeficiency occurring in association with IRF8 mutation is likely to involve defects of NK cells in addition to previously described loss of monocytes, DCs, and macrophage function. These findings define a novel, critical role for IRF8 function in NK cell development, extending the previously described range of phenotypes associated with IRF8 mutation in humans and identifying IRF8 mutation as the fourth genetic explanation for classical NKD leading to aberrant NK cell development and association with susceptibility to viral disease.
Human NK cell preparation and target cell lines. PBMCs were isolated by density centrifugation over Ficoll-Paque lymphocyte isolation medium according to the manufacturer’s protocol (Amersham). For enrichment of NK cells for qPCR analysis, whole blood was incubated with RosetteSep (STEMCELL Technologies) before density centrifugation. For isolation of cells from tonsils, tissue was obtained from routine tonsillectomies and mechanically separated by passing through a 40-μm strainer prior to isolation of secondary lymphoid cells by density centrifugation. Human K562 target cells were used for 51Cr release assays and maintained in supplemented RPMI media as previously described (72). K562 cells were acquired from American Type Culture Collection and routinely confirmed to be mycoplasma negative.
Murine NK cell phenotyping. Irf8–/– mice were generated as described previously (29) and were a gift from Keiko Ozato (NIH, Bethesda, Maryland, USA). Male and female mice between 9 and 12 weeks of age were euthanized upon arrival in accordance with Baylor College of Medicine’s animal care guidelines. Spleens were removed and single-cell suspensions prepared by mechanical separation and density centrifugation as previously described (73). Blood was obtained by heart puncture immediately following euthanasia. All cells were maintained in PBS/2% FCS at 4°C throughout the staining procedure. Cells were stained for viability with LIVE/DEAD cell staining kit according to the manufacturer’s instructions (Thermo Fisher). Rat anti-mouse Fc Block (Becton Dickinson) was added for 10 minutes on ice, and then fluorophore-conjugated specific antibodies against extracellular markers were added for 30 minutes (antibodies listed in Supplemental Table 4). Cells were washed once in 2% FCS/PBS, then fixed in a final concentration of 1% paraformaldehyde. Cells were acquired and data analyzed as described for human flow cytometry and immune phenotyping.
Generation of lymphoblastoid cell lines. Lymphoblastoid cell lines were generated from patient PBMCs by addition of EBV supernatant as previously described (74). Briefly, PBMCs were transduced with a B95-8 EBV supernatant and cultured in RPMI medium with 10% FBS, 2 mM glutamine, and 1 μg/ml cyclosporin A. Cell lines were confirmed mycoplasma negative before their use in experiments.
NK cell functional assays. Standard 51Cr release assays were performed in round-bottomed plates against K562 target cells as previously described (75).
Flow cytometry and immune phenotyping. Fluorophore-conjugated antibodies used for multiparametric flow cytometry analysis of patient PBMCs are listed in Supplemental Table 4. Where indicated, stimulation for the detection of intracellular cytokines was by PMA/ionomycin for 4 hours in the presence of brefeldin A followed by fixation and permeabilization with BD Cytofix/Cytoperm. For intracellular staining of IRF8 by flow cytometry, cells were permeabilized using the FoxP3 transcription buffer staining kit (eBioscience) followed by incubation with IRF8 eFluor 710 (clone V3GYWCH, eBioscience). Flow cytometry was acquired on a BD Fortessa configured for 14 colors. All analysis was done in FlowJo X (Tree Star). Positive populations were identified as those with fluorescence greater than that of isotype or fluorescence-minus-one controls. Cytokine bead arrays were performed with custom BD Biosciences CBA Flex Sets using IL-12, IFN-γ, TNF-α, and IL-10 probes. PBMCs (2 × 106) were incubated for 4 hours with 105 EBV-transformed B cells previously induced to lytic cycle with 200 ng/ml phorbol 12-myristate 13-acetate. Data were analyzed with FlowJo X (Tree Star), and statistical analysis was performed and graphed using Prism 6.0 software (GraphPad Software).
Imaging flow cytometry. Cells were fixed and permeabilized using FoxP3 transcription buffer (eBioscience) followed by incubation with IRF8 eFluor 710 (clone V3GYWCH, eBioscience) and DAPI. Samples were acquired on an ImageStream MkII (EMD Millipore) with a ×40 objective. Spectral compensation was applied using single-stained controls. Images were processed and exported using IDEAS software (EMD Millipore). Similarity score was calculated in IDEAS as a measure of colocalization.
Western blotting. Lymphoblastoid cell lines (3 × 105) from patient or healthy donor were lysed, separated by 4%–10% SDS-PAGE gel, then transferred to nitrocellulose membrane, and blocked with skim milk. IRF8 was detected with anti-ICSBP (clone C-19, Santa Cruz Biotechnology) and actin with anti-actin (catalog A2066, Sigma-Aldrich) followed by goat anti-rabbit IRDye 700 secondary antibody. Proteins were detected on a LiCor Odyssey.
Quantitative reverse transcriptase PCR. RNA was extracted from enriched NK cells or secondary lymphoid cells (SLC) using DirectZol (Genesee Scientific) or RNeasy (Qiagen), and cDNA was made using VILO (Invitrogen). IRF8, PRDM1, NFIL3, and IRF4 were amplified on a Roche Light Cycler by Taqman gene expression array. GAPDH was used to normalize expression for each sample. Each condition was performed in quadruplicate. Analysis was performed with Roche Light Cycler software and exported to Excel before graphing with Prism 6.0 (GraphPad software).
Genetic analyses. Genomic DNA was extracted from EDTA-preserved nonheparinized blood samples using the Gentra PureGene Blood Kit (Qiagen). Whole exome sequencing was conducted as previously described (23). Briefly, exonic portions of genomic DNA fragments were captured in solution using custom VCrome probes (NimbleGen). Resulting DNA was sequenced using Illumina HiSeq 2500 equipment. Data processing and variant annotation were performed per standard pipeline analyses. Variants were evaluated using both recessive and dominant models. Bioinformatic filters were placed using a minor allelic frequency less than 0.005 in recessive models within the Baylor-Hopkins Center for Mendelian Genomics (18), ESP5400, 1000 Genomes, and ExAC databases. Potential recessive variants were also excluded if present in the ExAC database with a homozygote or hemizygote count of 10 or greater. For compound heterozygous analyses, variants were excluded if both variants were present in the maternal exome or in the exome of the unaffected brother. For autosomal dominant model analyses, variants were excluded with minor allelic frequencies greater than 0.001 in the same databases and if present in the ExAC database with an allele count greater than 5. Variants were confirmed by Sanger sequencing; primers were constructed using Primer3 (http://biotools.umassmed.edu/bioapps/primer3_www.cgi), and amplified DNA constructs were sequenced by the Baylor DNA Sequencing Core Facility. Sequences were visualized using 4Peaks software (Nucleobytes). For the deceased sister, formalin-fixed paraffin-embedded gallbladder tissue slices were retrieved from the Pathology Department at the University of Pennsylvania (Philadelphia, Pennsylvania, USA). DNA was extracted by the Baylor Human Genome Sequencing Center for Sanger sequencing.
In vitro NK cell differentiation. CD34+ precursors were isolated from peripheral blood of the patient or healthy donor and highly purified by fluorescence-based cell sorting. Following purification, cells were incubated on mitotically inactivated OP9-DL1 stromal cells (a gift from J.C. Zúñiga-Pflücker, University of Toronto, Toronto, Ontario, Canada) in media containing 5 ng/ml IL-3, 20 ng/ml IL-7, 10 ng/ml FLT3L, and 10 ng/ml IL-15 for 4 weeks. After culture, cells were phenotyped by FACS in parallel with control cells from a healthy donor.
RNA isolation and gene expression analysis. NK cells were isolated by FACS sorting to greater than 95% purity following enrichment by RosetteSep negative selection (STEMCELL Technologies). Fifty to a hundred nanograms of RNA was analyzed with the Human Immunology v2 probe set using a NanoString nCounter. Background correction was done using the mean of 8 negative control probes. Normalization was performed by calculation of the geometric mean of positive controls and content normalization parameters (15 housekeeping genes). Data processing was performed using nSolver software, and data were exported to Ingenuity Pathway Analysis for further analyses. Genes up- and downregulated greater than 1.5-fold in samples relative to the mean of all 3 healthy donor controls were considered significant.
Luciferase assays. Constructs encoding WT human IRF8 or allelic variants A201V and P224L were generated in the pIRES2-EGFP expression vector (Clontech). These were cotransfected with vectors encoding IRF1 or PU.1 and reporter luciferase vectors harboring interferon-stimulated response element (ISRE) or EICE motifs and quantified using the Promega dual luciferase assay system. Details of the PSMB8 and TAPASIN promoter luciferase vectors have been described previously (76).
Statistics. Statistical analysis was performed using Prism 6.0 (GraphPad Software). Unpaired 2-tailed Student’s t test was used to compare data sets. Ordinary 1-way ANOVA with Tukey’s multiple comparisons test was performed for multiple comparisons. For all data shown, error bars denote SD. A P value less than 0.05 was considered significant.
Study approval. All studies were performed in accordance with the Declaration of Helsinki with the written and informed consent of all participants under the guidance of Children’s Hospital of Philadelphia, NIH, University of Newcastle, and Baylor College of Medicine Institutional Review Boards. Animal studies were performed in accordance with the Baylor College of Medicine and NIH Animal Care Committees.
The study was conceptualized by EMM, JRL, and JSO. Methodology was developed by EMM, VB, GMD, MC, SMH, M.A. Caligiuri, JRL, RAG, SP, and JSO. Investigation was performed by EMM, MDK, IKC, DFL, SNJ, DMM, ASP, ZCA, TNC, JTG, SP, LSA, GDH, JBS, MHS, LBW, DTL, ST, M.A. Care, SM, AGF, and EPS. EMM and JSO wrote the original draft of the manuscript. EMM, JRL, VB, MC, GMD, MDK, and JSO reviewed and edited the manuscript. Funding acquisition was by JSO and JRL. Clinical care was provided by JSO, SMH, SS, MDK, AJC. Resources were provided by KO.
The authors thank all the patients and their families, particularly the proband’s, for their engagement in this study. The authors also thank Linda Monaco-Shawver for technical assistance. This project was supported by the Genomic and RNA Profiling Core at Baylor College of Medicine and the expert assistance of the core director, Lisa D. White, and Mylinh Bernardi. This work was supported by NIH–National Institute of Allergy and Infectious Diseases grants R01AI067946 and R01 AI120989 to JSO, the Jeffrey Modell Foundation, and NIH (National Human Genome Research Institute/National Heart, Lung, and Blood Institute) grant U54HG006542 to the Baylor-Hopkins Center for Mendelian Genomics.
DFL’s present address is: Allergic Disease Associates, Philadelphia, Pennsylvania, USA.
EPS’s present address is: Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
GDH’s present address is: Washington University School of Medicine, St. Louis, Missouri, USA.
Conflict of interest: J.R.Lupski has stock ownership in 23andMe, is a paid consultant for Regeneron Pharmaceuticals, has stock options in Lasergen, Inc. is a member of the Scientific Advisory Board of Baylor Genetics, and is a co-inventor on multiple United States and European patents related to molecular diagnostics for inherited neuropathies, eye diseases, and bacterial genomic fingerprinting (5294533; 5306616; 5523217; 5599920; 5667968; 5780223; 6132954; 6713300; 7141420; 7189511; 7192579; 7273698; 7537899; 8129353; 9365899; 0424473; 0610396; 0989805). The Department of Molecular and Human Genetics at Baylor College of Medicine derives revenue from the chromosomal microarray analysis (CMA) and clinical exome sequencing offered in Baylor Genetics (BMGL: http://www.bmgl.com/BMGL/Default.aspx).
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Jenne CN, et al. T-bet-dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow. J Exp Med. 2009;206(11):2469–2481.
Male V, Nisoli I, Gascoyne DM, Brady HJ. E4BP4: an unexpected player in the immune response. Trends Immunol. 2012;33(2):98–102.
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Sanborn KB, et al. Myosin IIA associates with NK cell lytic granules to enable their interaction with F-actin and function at the immunological synapse. J Immunol. 2009;182(11):6969–6984.
Doody GM, Stephenson S, McManamy C, Tooze RM. PRDM1/BLIMP-1 modulates IFN-γ-dependent control of the MHC class I antigen-processing and peptide-loading pathway. J Immunol. 2007;179(11):7614–7623. | 2019-04-25T02:36:05 | https://www.jci.org/articles/view/86276 |
The Cut has many restaurants and coffee shops tempting you to try new cuisines or inviting you to spend the afternoon reading a book and enjoying a cup of coffee as you watch the world go by. The Cut Bar is attached to the Young Vic Theatre, a social bar and restaurant serving classic burgers.
Home to the notorious Old Vic Theatre, The Cut joins neighbouring Lower Marsh to form the commercial heart of the area. Properties include period conversions and new developments, attracting professionals who wish to enjoy living a short distance from the City but also with access to green space, found at the Waterloo Millennium Green.
Of course, typical nightlife in The Cuts nightlife involves a meal and drinks with friends and seeing what treats the Old Vic Theatre has on offer that evening. Shows include comedy, musicals and independent plays. | 2019-04-21T16:19:01 | https://www.garrettwhitelock.co.uk/pages/area-guide-the-cut |
Brainwashed - Drew McDowall, "The Third Helix"
Drew McDowall, "The Third Helix"
The trajectory of Drew McDowall’s recent resurgence as a solo artist continues to be a compelling and unpredictable one, as The Third Helix is quite a bit different from either of his previous Dais outings. If Collapse felt like a lost Coil session and Unnatural Channel felt like a vintage noise tape, Helix feels like the assimilation of those two sides into something more forward-looking and unique. It does not quite unseat Collapse as my favorite of McDowall's albums, but a couple of pieces easily rank among his finest work to date. More importantly, the album as a whole cumulatively casts a wonderfully immersive and disorienting spell that is ideal for headphone listening. This is the first of McDowall's albums that makes me feel like he is currently in the midst of a fresh new creative phase rather than merely unearthing and reworking a deep backlog of unreleased material.
The opening "Rhizome" embodies a curious dichotomy that runs throughout The Third Helix, as McDowall seems equally drawn to both sublime beauty and collapsing, distended ruin. Those two sides rarely come together elsewhere on the album, but they certainly do on "Rhizome," making it the strongest and most instantly gratifying piece on the album. While it deceptively begins with a disjointed series of warmly shuddering string flourishes adrift in a haze of slow-motion synth swells, the piece soon coheres into a recognizable structure…then unexpectedly blossoms into rapturous swirl of choral voices and achingly beautiful strings. Once he hits that wonderful crescendo, however, McDowall immediately sets about dismantling it and the piece dissolves into a clanging and buzzing industrial coda. The Third Helix never quite delves into such naked and unambiguous beauty ever again, but it does feature at least one another piece of similar caliber, as the densely throbbing and see-sawing "Impulse" gradually transforms into a lysergically heavy feast of rattling drones and garbled voices. It manages to evoke a mood that is best described as "nightmarishly beautiful," resembling a simple string piece that has been stretched and smeared into lurching horror. I also quite like "Nothing is Hidden," which sounds somewhat similar, yet excises everything organic or melodic to leave only a shambling, hissing, and grinding mechanized hellscape.
Interestingly, the album's brief closer "Immanent Condition" goes in completely the opposite direction, unfolding as a quietly melodic synth theme that merely frays at the edges rather than completely corrode and collapse. The rest of the album takes a much more subtle and willfully destructive approach though, as the appeal lies less in the strength of the motifs and the compositions than it does in how McDowall plays with time and pulls everything apart to weave a fragmented and kaleidoscopic fantasia. I have no idea how much of that strategy was premeditated, but it definitely seems like McDowall had enough strong ideas for only half an album and ingeniously opted to use the second half to mangle and manipulate his lesser ideas in interesting ways. In some cases, such as the excellent "Proximity," it is easy to see the ghost of a fully formed idea driving the churning and heaving abstraction. In most of the other cases, however, the degree to which McDowall succeeds is directly related to how closely I am listening to how things break apart. For example, "YLL" feels like a very simple pattern that has been reduced to a creeping granular ooze. Elsewhere, "Tendrils" is a quietly pretty ambient piece drifting through a reverberant ruin of stomping and clattering machinery, though it eventually loses its way and seems to morph into a completely different piece altogether. The remaining piece, "False Memory," is a bit of a fascinating outlier, as collaborator James K's vocals swoon and slide in a bleary haze over an unpredictably throbbing and jackhammering backdrop. The prominent presence of vocals is an obvious departure for McDowall, but it is equally significant that he completely abandons his usual pattern-manipulation for something more unpredictable and organic. I like it, but it sounds like it belongs on a completely different album or possibly in some kind of avant-garde theater mindfuck.
If The Third Helix has a weakness, it is mostly that some of the more fragmented and deconstructed pieces are too insubstantial to make a real impact on their own or linger in my memory after they are gone. Also, a strong appreciation for nuance, texture, and detail is quite helpful in unlocking the full depth of McDowall's artistry, as the straining seams, falling detritus, and sluggishly hallucinatory timescale play a crucial role in elevating several of these pieces into something much more compelling than is immediately obvious. The Third Helix would probably be a more unambiguously fine album if it featured a better balance between melody/harmony and clattering post-industrial experimentation, yet it still feels like a significant step forward to me, as McDowall has found a novel way to work around his limitations. He has always been much better at coming up with great ideas than he has been at building those ideas into strong compositions with a satisfying arc. With this new approach to time-stretching, however, McDowall manages to drag and strain even the simplest ideas into song-like durations. If that was all he managed to do, it would not be much of an achievement, but almost every one of those distended and broken fragments plays a significant role in the assembly of a slow-burning, coherent, and wonderfully warped and dreamlike whole.
Samples can be found here. | 2019-04-24T00:21:25 | http://media.brainwashed.com/index.php?view=article&catid=13%3Aalbums-and-singles&id=11759%3Adrew-mcdowall-qthe-third-helixq&tmpl=component&print=1&layout=default&page=&option=com_content&Itemid=133 |
I interviewed Antoine Wright, one of the co-hosts of the Theotek Podcast. Antoine’s a mobile tech and mobile ministry expert. He’s a consultant to believers and churches in using mobile tech to communicate the Gospel. He also helps people and companies with their user-interface design and other general tech topics.
This is the first in a 5-part interview series with our co-hosts on the Theotek Podcast.
Be sure to listen or watch all the way to the end since we ended with our Theotek Quiz, a 7-part questionnaire meant to help people learn more about the subject being interviewed. It’s a fun way to get to know our guests.
Follow Antoine on Twitter at @arjwright. | 2019-04-26T03:40:31 | https://www.kevinpurcell.org/antoine-wright-from-the-future-theotek-extra/ |
Chloe mixed-media evening gown with metallic, sequin embroidery, and sheer panels.
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Galvan two-tone evening gown in lightweight stretch-jersey. Plunging halter neckline. Twisted waist detail. Cutouts from side to back. Draped skirt. Thigh-high leg slit. Hidden back zip. Floor-length hem. Viscose; bodice, viscose/nylon/spandex. Lining, polyester. Made in UK.
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This petition made change with 3,789 supporters!
Good news everyone, Max is going home!! If you're an animal lover please read the petition and sign it anyway. On behalf of Max, thank you!!
Max, an 85 pound Argentine Mastiff, is being unfairly imprisoned at the Denver Animal Shelter. On Tuesday, Feb 7th Max and his owner were enjoying a late afternoon walk when Max ran onto the frozen pond. The ice broke under his weight and Max was stranded in an icy pool of water. A firefighter from the West Metro Fire Dept. risked his life to rescue Max. The firefighter's heroics was captured by a news helicopter from KUSA, 9News, Denver. The next day Max, his owner and the firefighter appeared on a morning news show. Kyle Dyer a news anchor for the station was conducting the interview when she leaned in towards Max's head. Max who has shown no signs of aggression in the past, bared his teeth at Ms. Dyer then, on live TV bit her on the lip. Ms. Dyer, who apparently is a huge dog lover, was taken to the hospital for emergency treatment and is expected to make a full recovery. In the meantime Max, whose rabies shots are up to date is being held in "routine" 10 day quarantine at the Denver Animal Shelter. Shelter officials have said that Max "most likely" won't be put down. Most likely? This unfortunate event was NOT Max's fault, this was the result of human error. Max was undoubtedly feeling stressed from the previous day's events and from being in a TV studio with bright lights and studio equipment, not to mention a slew of well-intended, but unfamiliar humans. Free Max from his imprisonment!!!
Denver (Colorado) Animal Shelter: Free Max the dog!!!
Cuttita Thom needs your help with “Denver (Colorado) Animal Shelter: Free Max the dog!!!”. Join Cuttita and 3,788 supporters today. | 2019-04-25T21:48:52 | https://www.change.org/p/denver-colorado-animal-shelter-free-max-the-dog |
How one family's tragedy ultimately revolutionized contemporary Christian music.
Known for such classics as "Easter Song," the Second Chapter of Acts was one of the major music groups in the forefront of the Jesus movement. But what happened, in the wake of personal tragedy, to bring together a brother and his two sisters to sing so boldly for their Lord? And what was life really like for a major contemporary Christian band in those early days?
In My Second Chapter, Matthew Ward tells his part of the storyfull of intriguing and humorous behind-the-scenes anecdotes and observations: growing up in a large family…orphaned at age twelve…finding the Lord in the California Jesus movement… becoming a music star…traveling the world…battling cancer…raising his own family … and much more all revealing God's faithfulness in every circumstance.
Join Matthew on his amazing personal journey from tragedy to dynamic faith that helped set contemporary Christian music on fire. And discover how God chooses whom he will to accomplish great and mighty acts.
My Second Chapter ePub (Adobe DRM) can be read on any device that can open ePub (Adobe DRM) files. | 2019-04-24T22:10:26 | https://www.ebookmall.com/ebook/my-second-chapter/matthew-ward/9781400070800 |
Better perhaps to learn personnel management skills.
Why is it that Poles are ‘under-represented’ – taking into account the relative size of the country – in the staff of the EU institutions? A group of Poles has lodged a complaint with the European Commission and the European Personnel Selection Office, raising doubts about the “surprisingly high” rate of failure for Polish candidates in an administrator AD5 competition. The rate of failure seems to have been much higher than for candidates in parallel competitions for Czechs, Hungarians, Latvians and Slovaks.
The exam had to be conducted in English, French or German, so there is also a suggestion that the Poles were being penalised on their language skills. Even though the results have not yet been published, the complainants point to other competitions where the reserve lists for Poles have not yet been filled.
An interesting feature of the case is that the complainants describe themselves as “a group of graduates from the College of Europe”.
The college’s graduates are famous for their networking skills and it seems that they have used them, in preparing their complaint, to compare notes on exam experiences and results across language groups. They have also been mobilising Polish MEPs and the Polish government.
A Commission spokesman said that the overall success rate for Polish candidates compared favourably with that in the other nine parallel competitions.
He said that a very low number of candidates had initially registered for the competition with only two-thirds turning up for the computer-based tests. The low level of participation had led to a shortfall for the reserve list.
So it seems that the Commission may yet resist attempts to force it to explain why it sets such uncharacteristic store by personnel management skills. | 2019-04-19T10:44:37 | https://www.politico.eu/article/polish-network-failures/ |
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When you're organizing a job for Bathroom Wall Panels in Maben, MS, you'll find good reasons to call Bathroom Wall Panel Guys. We offer the highest customer care ratings, the highest quality equipment, and the most useful and successful money saving practices. Our company has the experience that you need to meet all of your ambitions. Contact 888-408-1113 if you need Bathroom Wall Panels in Maben, and we are going to work together with you to expertly accomplish your project. | 2019-04-26T10:04:46 | http://www.bathroomwallpanelguys.com/ms/bathroom-wall-panels-in-maben/ |
Deeply rooted in ancestral traditions, this amulet is believed to provide protection against the Mal de Ojo (evil eye) especially to newborns. It is represented as a clenched fist. Should it ever break, it means that its power has worked and the bad energy was reversed.
This pendant is 18k gold plated - it will not tarnish and is hypo-allergenic. | 2019-04-24T17:46:44 | https://everythingsoulfulshop.com/collections/protection-collection/products/azabache-pendant-gold |
Minimally invasive or key-hole Bunion surgery is a technique that reduces the size of the incisions during the surgical procedure.
What does Minimally invasive bunion surgery involve?
Minimally invasive or key-hole Bunion surgery is a technique that reduces the size of the incisions during the surgical procedure. The Minimally invasive Bunion surgical technique has evolved and is in its third generation. It involves performing an osteotomy of the first metatarsal and phalanx through keyhole incisions and stabilizing with screws under fluroscan guidance. Dr Dracopoulos has completed three cadaver workshops on this method and recently spent time in Sydney learning this technique from a recognised leading surgeon in the field. Committed to offering patients the latest technology Dr Dracopoulos has now commenced keyhole or minimally invasive surgery for selected bunion cases.
What are the benefits and risks of Minimally invasive bunion surgery surgery?
MIS involves a much smaller skin incision through which the entire joint replacement operation takes place. In total knee replacement surgery this can often mean patients receive an 8-9cm surgical scar rather than 24-25 cms. This can also mean decreased post-operative pain due to reduced surgical disruption to surrounding muscles and tendons, a shorter stay in hospital and a faster return to everyday activities.
In addition, as with any surgery there is a risk of deep vein thrombosis (blood clot) with potentially very serious consequences.
Occasionally (but not often) patients may have such a complication so severely that they feel worse off and need further correction surgery to address this, possibly by fusion of the great toe. | 2019-04-20T12:58:28 | https://www.orthosa.com.au/treatment/mi-bunion-surgery/ |
Mazatlán in the World Series SemiFinals | ¡VidaMaz!
We won nationals; Mazatlán was first in all of Mexico.
We travelled 55 hours by bus to beat Vietnam. We beat Michigan and Lafayette, the host team. Czech Republic lost, as did Texas. We made it to the semifinals.
Today, 3-2, Puerto Rico bested us. We gave it our all. PR had played three games in five days, we’d played five. Their fielding was incredibly sharp; they’re good at the double plays. We played very well. César and Pedro both pitched wonderfully. Puerto Rico, however, well deserved the win. Click on any photo to view it larger or see a slideshow.
We hope you’re feeling better!
Sadly, we are out. We congratulate PR. We congratulate all those who travelled so far to be here, as well as the host teams. We thank all the host families, two of whom have hosted for five years in a row! We thank the interpreters, and the local Mexican-American community, who showed up every day (till past midnight twice over) to cheer us on. Bless you!
Today we were visited by Larry, a Mazatlán snowbird for the past 12 years.
Only Puerto Rico’s cheering section rivaled ours, and they didn’t come close 😉 Mazatlecos know how to make noise, how to party, and how to play baseball! And, we are all tired!
Puerto Rico will play in the championship tomorrow. We are not yet sure who they will be playing, but it will be either North Carolina or California.
The Pony League was founded in 1951 in Washington, PA at the local YMCA. “Pony” stood for “Protect our neighborhood youth.” It has nine age groups, from 4-19, and is in 21 countries. The US is divided into four zones, plus internationally there are the Asia-Pacific, Caribbean, European, and Mexican zones. The Pony League hosts seven international World Series each summer for the varying age groups. Mazatlán won the Mexican National Title in two age categories in 2015: Colt (age 15-16, which took place here in Indiana) and Pony (age 13-14, which took place in Pennsylvania). Congratulations!
← Mexico Beats Vietnam 6-0!
Indeed they did! Thanks for joining us virtually!
Pingback: AWESOME Musical Event You Don’t Want to Miss! | ¡VidaMaz! | 2019-04-19T06:40:49 | https://vidamaz.com/2015/08/11/mazatlan-in-the-world-series-semifinals/ |
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I am a very happily married woman, who is totally blessed with an amazing husband, two strong and loving sons, and their wives, who are each a wonderful addition to our family. Faith has always been important to me. My husband and I would never have the marriage we have today if God was not the foundation of our marriage.
I am a cradle Catholic, and received twelve years of Catholic Education. My parents made sure to take my sisters and me to Mass on Sundays and Holy Days. One of my sisters is quadriplegic, and “back in the day”, disabled people didn’t get out much. That led to Masses in our home, and some “Charismatic” Catholic functions (which I did not understand). We also said an occasional rosary as a family.
As I grew in faith, I wanted nothing to do with the rosary. I believed that a person should pray straight to Jesus, that it was blasphemy to pray to the Blessed Mother. That belief would change drastically…about a year and a half ago, my faith started to deepen as never before.
In the Spring of 2012, my husband and I happened to drive past a group of about 25 people, who were praying, at the Pro Life 40 Days for Life, at a local abortion clinic. I wanted to quietly show our support. As we were getting closer to the group (who were standing in an oval shape on a grassy area), I could feel the Holy Spirit so strong that it made me cry. The spirit was so intense that it felt like a wall of love. I saw a woman holding a sign that stated “I regret my abortion”, and I felt great admiration for her courage and deep empathy for her pain. I continued to feel the Spirit while we drove past the group, and then once we passed them, it disappeared. I looked over at my husband, and he had tears in his eyes…he felt the Spirit too. I realized that they were praying the rosary, and it was the Holy Spirit around them; they were standing on Holy Ground.
A little while went by, and I wasn’t even thinking of the event at 40 Days for Life. I was trying to figure out what I could do for Lent that would be meaningful. I was literally PULLED and DRAWN to pray the rosary. It was like I had no choice…I started to say the rosary almost every day. (Remember how I had previously avoided the rosary?) To make a long story short, I have been praying the rosary almost daily ever since, for the conversion of sinners, and for the hearts and souls of the people the Holy Spirit whispers to me every day. The meditations and prayers have increased my faith immensely – our Blessed Mother has led me closer to Her Son. My relationship with Jesus is more intense than ever, and I look forward to the revelation of each new day, to bring us even closer.
Relationships have always been my life’s focus. I truly believe that the love of Jesus is shared through the people we interact with every day, starting with immediate family, and then branching out all the way to the people we may casually pass on the street.
The ability to feel a person’s inner struggles comes easily to me. Often times, I actually feel a person’s pain or conflict. Up until recently, this ability to take on people’s emotions left me very confused. My mood would swing from feeling happiness in my day-to-day life, and all of a sudden, would change to extreme anger or sadness. I did not understand I was picking up the emotions and spirits from others. Now I realize the empathy that comes naturally to me, is a gift from God. This gift allows me to know when someone is in need.
I just discovered your blog and you are very inspirational! Your stories are written from the heart and are entertaining as well as spiritual and informative. Thank you so much for posting how God is working in your life. I pray that God will continue to grow and bless you!
Thanks, Abby, for stopping by and leaving such a sweet comment. I believe we all have a story to share to touch and uplift eachother, and share the love of Jesus. I LOVE your blog…very honest and heartfelt sharing of your journey with Christ. May God hold you in the palm of His hand and continue to bless you and your family.
Thanks for stopping by and like our roll with it Wednesday 😀. You are welcome to stop back anytime 😀 God bless you!
My pleasure! I love to share things that touch my heart. Blessings to you!
I read your blog post about your experience with God’s angel and agree, God sends His angels to protect His children. Something happened to me that can only be explained as intervention from an angel of God.
Lyn, I think it is so important to know each others’ stories. I would love to hear yours. Blessings to you!
Thanks for your visit at Wings of the Dawn and for your encouragement there. I appreciate your sharing a part of your life and walk with Jesus here. God bless you.
It is wonderful getting to know new friends through the sharing of life stories/journeys. I feel that God is blessing me immensely….each day I am filled with inspiration and love through so many different, unique perspectives. The commonality is the search for Christ’s peace and love in our lives, in order to share it with others. May God bless you, too!
Thanks so much for visiting my blog and liking my post. I hope it was of encouragement and blessing to you!
I am really encouraged by your blog and it’s name for it speaks volumes, especially regarding Christ. Many blessings to you as you continue to encourage others!
So sorry it took so long to respond. Thank you for your kind words. May God continue to guide and bless you!
Just wanted to say thank you so much for coming by my blog, and to ask you if you might be able to possibly come back and re-read this post. I added something to the next to the last paragraph that I think is very important to my point.
Thanks so much for letting me know about the add to your post. Such powerful words about God’s healing love. Love and blessings your way!
Just wanted to stop by and thank you for “liking” my latest post, which, apparently, you read before I had finished posting it! 🙂 Ain’t WordPress amazing? 🙂 Thanks, again.
Loved your post. God should fill our entire hearts and lives, not just a little “God” space that we “squeeze in”.
Your story is so inspiring. Thanks for sharing. Isn’t it wonderful how much prayer can enhance our lives with the Holy Spirit! Love reading your blog. So blessed to have found it!
Thanks so much for stopping by and for your kind words. Yes, it is amazing how the Holy Spirit directs us and fills us with His love, when we invite Him in. Have a blessed day.
Hannah, thanks so much for taking the time to read and comment. I look forward to getting to know you:-) May God carry you and bless you and your family.
Hi Bernadette! Thanks for stopping by and following me on Reflections From the Heart and on my Twitter! I read some of your material as well and have reciprocated 🙂 I am now one of your fans. Blessings!
I look forward to getting to know you through your posts:-) May God bless you!
So sorry, I didn’t mean to toot my own horn. I just remember a new follower who had searched for it told me this and I couldn’t find the comment on any of my blogs. (So I’ll keep searching) Thanks for letting me know.
Bernadette, I love that name. I am just so excite to read that you read the book of Sister Patricia of Called by Joy. Thank you for reading the book! Blessings to you and yours. Perpetua.
Do you know that the gravatar I am using and the eyes on my header is St. Bernadette?
Yes, I thought so but wasn’t sure:-). I am reading “Bernadette Speaks” by Rene Laurentin now. I thought your picture looked like the one on the cover of my book.
Do you have a special devotion or interest in Saint Bernadette?
I am so sorry it has taken me this long to respond. Thank you for nominating me for the Very Inspiring Blogger Award. It was totally unexpected, and really humbles me.
After much thought, I decided against accepting awards. Although, it is an honor, I am focusing on writing what the Lord inspires me to write, written in the way that He guides me to.
I enloy reading your blog, and look forward to getting to know you more through your posts.
Thanks for dropping by my blog. I was inspired with what I have read so far. I hope you will continue sharing your heart and faith with the world. Let’s continue to Know Him and Make Him Known.
One never knows what power that a kind word or gesture will have….
I had 8 years of Catholic education and my family said the rosary together every night (my poor knees on the hardwood floor).
You are so right…we usually do not see the power and effect of our kindnesses done in love.
Hi Lorrie, I am happy you stopped by, too! It is wonderful to know someone who understands what this gift feels like. I’ve had it for my whole life too, but like you, did not understand. About two years ago, I was finally enlightened, and am also learning to distinguish what is “mine” and what I am picking up from someone. And that “someone” may be in a different location, or I can pick it up through writing. Are you also very good at reading body language? I never was aware before, that I am constantly reading body language. It is second nature to me.
I would love to get to know you, and I may have some info that would be helpful to you:-) I look forward to reading your posts.
Oh Bernadette. ..that is so wonderful for you to offer! Yes…I read body language too. From a very young age I could walk in to a room and know exactly what is going on. I can tell when people don’t like each other even if they pretend really well. I also get energy from reading and from loved ones out of state.
It can all be very confusing sometimes. I think I now understand that throughout my life there were times I would suddenly get so sad…and I wouldn’t know why.
I fought this…or just didn’t understand it most of my life…but I am embracing it now…and it feels much better!!!
Thank you so much for your kindness 🙂 I’m so happy to meet you!!
Thank you again for hearing the cry of my heart and reaching out. I am doing much better, mostly thanks to your encouragement and insight. I shall never forget your kindness!
So happy to hear you are doing better. Don’t ever hesitate to contact me if you’d just like to talk, or if there is something you may need:-) I will keep you in my prayers.
Isn’t it amazing how God uses all of our experiences to build His kingdom? We are all interconnected!
I have left a comment on your Post about forgiveness blmaluso and yes I often speak to Jesus and my Abba Father and I feel compassion for those who are hurting and I also stand up for God’s Truth, including the evil of Abortion, not because I have to but because I want to, I Love Him.
The Scripture tells us we have one Intercessor, Jesus Christ, He is the only person who was sinless.
I would appreciate blmaluso if you would please share the Scriptures that confirm we are to pray to those who are dead to have our sins forgiven, like Mary and those that the Roman Catholic Church called Saints, which is what we all are in Christ Jesus and where does it confirm repetitious prayers are acceptable like when you use the Rosemary.
It is not Love or kindness to allow others to believe and teach error.
Just to clarify if you are making fun of the rosary…it is a rosary, not the rosemary.
No blmaluso, I was not making fun, I think using the rosemary is very sad, it has no Scriptural foundation, in Truth it opposes it . I’m Dyslectic and often spell words wrong, it’s something I have lived with all my life, I also can’t write in detail without the Lord’s leading and with being a cracked vessel I’m thankful He is the Super Glue and what He fixes never comes unstuck.
I have never claimed to pray to Saints or Our Blessed Mother for forgiveness of sins. Only the Lord can forgive our sins, and our salvation is found in and through Jesus.
http://www.rosary-center.org/howto.htm#loaded Make sure to click on the mysteries…Joyful, Luminous, Sorrowful, and Glorious to see what the meditations are.
The Rosary is a meditation on the life of Jesus. When I pray the rosary, I ask Mary to pray for me, and also to lead me closer to Jesus, her son. I also pray for the conversion of sinners; for the opening of eyes, ears and hearts to Jesus’ saving love and peace.
Be very careful of what you believe and “teach” regarding Church error. I pray that the Holy Spirit continues to guide you and lead you on your journey to Him.
Anne, thank you for your comment. I know you are speaking from your heart, although your “knowledge” is misdirected and misinformed. When I have a few moments to answer more in detail, I will answer your concerns about the Catholic Church.
That being said, I will not debate back and forth the validity of the only Church that was started by Jesus himself. All other churches are man made, being led by different “leaders” or led by the people themselves. Why would I trust someone other than Jesus who entrusted the Church to Peter? Why would I trust your interpretation, instead of putting my faith in a Church that traces back to The Lord Himself?
If you are truly searching for THE TRUTH and not just throwing daggers, please look up some Scott Hahn books about the Mass, and other aspects of the Catholic Faith. You can check out my Books page if you are interested in learning about the Catholic faith, instead of perpetuating what you believe the Church is.
Again, thank you for reading, and thank you for your comment. I will keep you in my prayers.
Bernadette, yes I like your real name much better than blmaluso, but it probably has meaning for you like Freedomborn does for me. I also believe that you feel you are right but your About message is all about feelings, there is no Scriptural confirmation for what you have been taught by your Church, in regards to Mary, the Rosary and other untruths, what you believe it only based on man’s own fleshy understanding and what they have propagated sadly for many years.
I too believe in God’s Universal Church, not meaning the Roman Catholic Church, as we know they were established later but God’s Church, which is World wide and includes people from every Country and Denomination as well as house Churches etc because it’s of the Heart, it’s not made of bricks and mortar or the traditions of men.
Something that is often misquoted by Catholics, is Jesus was saying that God’s Church would be built on what Peter said not on Peter “Jesus is the Rock ” (see below) and He is The Head of God’s Church, not a man and we are the Body of Christ and so was Peter and so is the Pope and when we pray in the Spirit and in Unity (Matthew 18:18-19) (Ephesians 6:17-19 – Acts 1:13-15 – Matthew 16:19 ) as you can see by these Scriptures our prayers are answered. But the Unity God wants is not based on man’s fleshy understanding, reasoning or logic but on His Truth.
Deuteronomy 32:3-5 Because I will publish the Name of the LORD, ascribe ye greatness unto our God. He is the Rock, His work is perfect: for all His ways are judgment: a God of Truth and without iniquity, just and right is He.
1 Corinthians 10:3-5 And did all eat the same Spiritual meat; And did all drink the same Spiritual drink: for they drank of that Spiritual Rock that followed them: and that Rock was Christ.
Something that is very important is we are to ask for and believe you have God’s wisdom and empowering by The Holy Spirit or we will continue to Trust in fleshy, or worldly understanding and remain in darkness, it’s a choice!
Anne, before I write to address some of your questions and accusations, I pray that the Holy Spirit opens our eyes, ears and hearts to each other in love. I ask that The Lord fills our hearts with His love, wisdom and understanding, and that we are open to His truth. I pray in the name of Jesus that we are used as vessels of his love and his direction.
I will address the Catholic Faith first. As I shared with you before, if you would like to learn the truth of the Catholic Church, please check out Scott Hahn. He has written many very informative, scripture based books on the subject. He also shared your questions and concerns regarding the Catholic Faith. “The Supper of the Lamb” would be very beneficial for you to read. Again, it is based in scripture.
It truly makes me sad that you are under such misconception and error regarding the Catholic Church. I understand where you are coming from…I had many of the same issues and questions for a few years. Until my heart filled up with the mercy and love of Jesus, and he opened my eyes of faith. My relationship with Jesus becomes more intimate every day, in a way I never even could have fathomed. The Catholic Faith allows me countless ways to journey with him and worship my Father in heaven. The key is the relationship we form to him, and how, when we are united with him, he fills our hearts with an overflowing love that spills out to all souls in need of conversions…the souls that need Him.
Even when I was riddled with questions and confusion regarding the Catholic Church, one thing kept me from leaving…..that is the Real Presence. (Catholic Church is the only Church that institutes The Holy Eucharist) Yes, the Eucharist is the Body and Blood of Jesus Christ, and I am privileged to be called to His banquet that He sets before us at the Mass.
I will not turn down the invitation to be one with Jesus.
I for one will not argue with Jesus and His gift to us to PARTAKE in the Last Supper with my Lord. Jesus was sacrificed ONCE for our salvation, and we offer that sacrifice at the Mass. What a privilege.
It seems that the spoken part by the angel Gabriel starts off with a greeting – “Hail” in some translations “Greetings” in others. I suppose it depends on what the translator was comfortable with and who is the target audience for each specific translation. According to Dictionary.com “hail” (in this sense) is a term that is used as a greeting for someone, sometimes signifying importance of that person.
Mary is ‘most blessed among women’ and ‘highly favored’ by God. How many other people in Scripture have received such designations – none.
Mary is considered of such high favor with God and Elizabeth recognizes that she is special only because of Jesus. Mary was chosen to bear Jesus by God, so God singled her out from all other women on the planet. Elizabeth recognized that she was bearing the son of God and so recognized that she was special.
The core of Catholicism is Jesus, not Mary. We ask Mary to pray for us and she LEADS us to Jesus. From personal experience, this is exactly what happened in my life. I always believed, but I did not have a relationship with Jesus. Since I have been meditating on the mysteries of the rosary, my relationship with Jesus has become more intimate.
We cannot simply neglect Mary. She plays an integral role in the redemption of the world. She said yes, Jesus was born and we were redeemed (by Jesus of course). One cannot simply talk about Jesus without being grateful to his mother. God did not choose to just place Jesus on earth as He could have; he chose for Jesus to have a real mother, and his mother is Mary. Also, if God is our heavenly father, and Jesus is his son and our brother, wouldn’t that make Jesus’ mother OUR MOTHER too? Wouldn’t she love us and want what’s best for us, which would be to lead us to Jesus?
The Hail Mary is not a prayer of worship, but it is a recitation of Scripture and then asking her to pray for us to God; much like asking our other Christian brothers and sisters to pray for us.
You say I base my faith on feelings. No, my faith is a gift from God. I will NEVER deny the all-consuming love I am surrounded and filled with because the Holy Spirit lives within my heart.
http://www.scotthahn.com/mary.html Information and answers to questions regarding the role of Mary and where she stands in the Catholic Faith.
Again Anne, my faith is a gift from God, and I choose to be a part of the one True Catholic Church on earth…that was instituted by Jesus himself. It is your choice to accept these truths or not. Although we are sisters in Christ, I do not choose to follow your interpretation of the scripture of what you believe truth is. Jesus instituted The Church so that we would not be left to fend for ourselves here on earth.
I am joy filled that you have accepted Jesus as your Savior, and stand firm on His Word. Be sure to keep your eyes, ears and heart open to The Holy Spirit’s whispers. You have all these “feelings” about the Catholic Faith because of misconceptions you have about what Catholics truly believe. You did not come across my blog site by accident. Make sure to pray, ask the Holy Spirit to guide you, and read some of Scott Hahn’s books. You will find more books, if you are searching for answers to your questions, on my favorite books page.
If you would like to continue our discussion, you may email me at [email protected]. I do not wish to cause unnecessary division that would harm relationships between brothers and sisters in Christ.
I have removed your latest post, for there are so many errors and misconceptions that I do not want them to even be seen on my site. Much confusion.
In my previous post I asked that our conversations be private, and you did not respect my request. After reading your last post, I ask that you do some of the reading by Scott Hahn that I suggested before contacting me. That would tell me that you are interested in actually having your questions answered rather than just slinging mud.
I pray that the Lord keeps you in his care.
Praying the rosary has changed my life…and also the lives of the people I have been praying for…it would be very hard for me NOT to share!!!
I have struggled with praying the rosary at times (I used to find it more like a chore than a prayer), but I’ve lately been praying it while driving and have been finding it to be very fruitful.
As you read, I am a cradle Catholic. However, in the last few years my faith has been strengthened in a way I could never have even imagined. It’s like my eyes and heart have been opened to the sheer beauty and depth of the Catholic faith…and all the ways The Catholic Church offers us to grow closer to Jesus. The more I learn, the more my spirit is filled with love, and the knowledge that there is so much MORE to learn and grasp:-) Praise the Lord and all His wondrous works!
Please let me know if you have any questions, or if you would like for me to refer books/CDs/movies, etc. I also try to keep some media/info on hand, and will mail to you if requested. My email is [email protected] if you would wish to contact me.
May God bless you on your journey. I will pray for you!
My goodness. I can really relate to you, especially in the sensitivity/empathy. It’s a burden at times, feeling all those emotions; but, as we both know, it’s a treasure to be able to sit along side a friend in need and help lighten the load of sorrow. Being a loving witness to both joy and pain – it is a gift from God. Only he can sustain it. On my own, I’ll run it right into the ground (as I did for decades). But under the control of the Spirit, it is my most treasured blessing.
I’m glad you found my blog. I hope we stay connected.
Lori, for so many years I just assumed everyone could “feel” what I feel. Actually, up until a few years ago I did not understand it at all. Looking back, I have been blessed with this “gift” since I was very young. I could feel the spirit and mood of the day from my father and became very sensitive to it. So many other memories through the years that I experienced without knowing what I was experiencing. Does that make sense???
Now, because I’ve learned to listen to what the Spirit shows me, I can pray (and sometimes intervene).
I’m glad we share this experience and can encourage each other.
Thank you for choosing to follow my blog. May ever day draw you closer to and more like Jesus in every way. May God bless your family and your blog richly.
Thank you, Tom. May God continue to bless you and all those your heart touches.
Hi Bernadette, thank you for reading and following my blog! Nice to meet you!
Hi Bernadette, thanks for liking Beauty Sleeps Inside at my Angie Mc’s Reblog Love https://angiemcreblogs.wordpress.com/2015/03/06/beauty-sleeps-inside/ .
I’m always glad to meet friends who love Mama Mary; what’s not to love?!
Thanks for stopping by and taking the time to comment:-) I truly appreciate it. I also look forward to reading more of your posts.
Beautiful story, you are evangelising one person at a time. I try to say the Rosary too everyday. I do it through the relevant radio app. God bless you, Terri.
Terri, thank you for your kind words of support:-) May God bless you, one day at a time!
Hello, I read about your faith path and right away thought about the Gifts of the Holy Spirit. I had taken an inventory of my Gifts of the HS last year and found it to be truly telling. Please check out the Charism of Mercy. It sounds like what your are talking about, feeling others pain and wanting to soothe it. http://www.maineholyspirit.org/charisms.html explains it briefly. It sounds like you could have some other charisms along with it. Ask your Church if they have The Catholic Spiritual Gifts Inventory by Sherry Weddell. Blessings to you.
Thanks so much for leaving such a thoughtful comment. Also, I love the list of Charisms….thank you! Yes, mercy is probably the very strongest for me, and there are more, including Discernment of Spirits. May God especially bless you today!
I am totally feeling your heart because it is very reflective of what God has also deposited in me. I think what makes the difference is what we do with the heart of God when he reveals it to us and your writing does express much of his love. Thank you also that you know that faith without works is dead so continue to help and make a difference in the life of others.
Simon, You are already on my prayer list. I don’t argue with the devil, however, I pray that the Lord will open your eyes to The Truth. I will not expose my readers to your spewing of darkness. Did I ever say I did not love you? Although I do not know you, you have been created in the Image Of God. It is sad to me that you do not accept this Truth.
“Many times, someone needs to know that ‘somebody loves me’ before they can accept that ‘God loves me’.” I completely agree! So very well said. Thank you for showing some of that love to me by stopping by my blog and liking one of my posts. What a blessing!
May God bless you and carry you through this dry time. I am also experiencing this. I will pray for you while I am praying the rosary. I honestly believe that God is closest to us, and working through us in a greater way when we are not FEELING it. Love has nothing to do with feelings. It’s wonderful when we have those warm and reassuring feelings, however, our love for God is a decision, and He will never abandon us. And we have His Mother to comfort and guide us, and His Spirit to work through us and fill us with true joy. | 2019-04-18T15:21:16 | https://somebodylovesmeblog.wordpress.com/about/ |
Having trouble keeping a lesbian relationship a secret?
Keeping a lesbian affair or relationship a secret can be very difficult. While it is easy to have a lesbian affair, it takes a great deal of willpower and determination not to let anybody know what you are up to. Action speaks louder than words and, unless you are completely out, you will be faced with fear of what if. What if your family will know? What if your good friends will know who, all this time, thought you’re straight? When you fall in love with a woman like you, things could change and your actions could change. You will always want to be with the other person and this unavoidable feeling of wanting her will make your actions obvious in the eyes of people around you. Always keep in mind that actions speak louder than words.
Don’t talk about it. Keep mum about your lesbian relationship with family and even with friends — even to your best friend. People talk so it’s better for you to just keep your mouth shut all the time if you want the lesbian relationship going.
Don’t go out. I mean go out, but not in the area where friends and family usually spend their time.
Avoid mails. Don’t let your lesbian lover send you mails or gifts at home. This is fine if you are living alone but very risky for those staying with family or friends.
Talk when you are alone. Make a point to talk to your lesbian partner when nobody is around or make sure that nobody will hear what you are talking about.
Erase text messages. Sending and receiving love text messages can be heart warming and exciting, but not deleting a message can have a very bad effect. People sometimes forget about things like having a cellphone handy all the time.
Hide your sexuality or sexual preference.
Keeping a lesbian relationship a secret can be very difficult as action speaks louder than words. There are also people who are good at spotting a secret lesbian affair. These people can easily see telltale signs of lesbian attraction or flirting so it is important not to show any signs of attraction towards women especially in public with members of the family around.
Can a straight woman be converted into a lesbian? | 2019-04-20T14:13:16 | http://www.y-woo.com/secretly-lesbian-relationship/ |
Patience is, in and of itself, a great challenge and it often holds the key to . . .
"While the handshake symbolizes the conclusion of a process, it simultaneously opens a new one, the need to forge quality implementation." | 2019-04-19T13:12:21 | https://johnford.blogs.com/quotes/patience/ |
Holidayinnbinghamton.com strives to ensure that its services are accessible to people with disabilities. Holidayinnbinghamton.com has invested a significant amount of resources to help ensure that its website is made easier to use and more accessible for people with disabilities, with the strong belief that every person has the right to live with dignity, equality, comfort and independence.
Holidayinnbinghamton.com makes available the UserWay Website Accessibility Widget that is powered by a dedicated accessibility server. The software allows Holidayinnbinghamton.com to improve its compliance with the Web Content Accessibility Guidelines (WCAG 2.1).
The Holidayinnbinghamton.com accessibility menu can be enabled by clicking the accessibility menu icon that appears on the corner of the page. After triggering the accessibility menu, please wait a moment for the accessibility menu to load in its entirety.
Holidayinnbinghamton.com continues its efforts to constantly improve the accessibility of its site and services in the belief that it is our collective moral obligation to allow seamless, accessible and unhindered use also for those of us with disabilities.
Despite our efforts to make all pages and content on Holidayinnbinghamton.com fully accessible, some content may not have yet been fully adapted to the strictest accessibility standards. This may be a result of not having found or identified the most appropriate technological solution.
If you are experiencing difficulty with any content on Holidayinnbinghamton.com or require assistance with any part of our site, please contact us during normal business hours as detailed below and we will be happy to assist.
Property owned and operated by Vista Property Management Company.
Trusted leader for professional property management services in USA and Canada. | 2019-04-25T14:14:03 | https://www.holidayinnbinghamton.com/website-accessibility-statement.html |
A show that started life in north Staffordshire is to head to Broadway for the New Vic Theatre’s first international tour.
The Newcastle-under-Lyme theatre-in-the-round’s production of Laura Eason’s adaptation of Jules Verne’s Around the World in 80 Days will have a 10-performance run at New York’s New Victory Theatre before heading down the coast to Florida.
She has reassembled the cast who took the show on a UK tour in 2017. Reprising their roles are Pushpinder Chani as Mr Naidu, Kirsten Foster as Mrs Aouda, Matthew Ganley as Colonel Proctor, Dennis Herdman as Inspector Fix, Michael Hugo as Passepartout, Nyron Levy as Captain Speedy, Joey Parsad as Miss Singh, Andrew Pollard as Phileas Fogg and Stefan Ruiz in ensemble roles.
Around the World in 80 Days will have a short tour, stopping off at Liverpool Everyman and Playhouse from Wednesday 17 until Saturday 20 April and Salisbury Playhouse from Tuesday 23 until Saturday 27 April. It then goes to New York from Friday 10 until Sunday 19 May and Florida Asolo Repertory Theatre from Thursday 6 until Sunday 23 June. | 2019-04-20T14:57:07 | https://www.britishtheatreguide.info/news/broadway-beckons-for-new-vic-s-10590 |
Charles Albert creates unique one-of-a-kind sterling silver jewelry, set with gemstones, fossils & minerals from around the world. All Charles Albert jewelry is meticulously hand-made by the finest silversmiths in the world. From our Mabe Blister Pearl Collection/ Freeform Mabe Blister Pearl Ring. | 2019-04-19T08:54:00 | http://www.itsagirlyworld.com/frmablperi.html |
July 2016: MMus graduate Mohamed-Aly ("Mo") Farag has recently composed a new Flute Concerto which was premiered by Peter Olah, flute, with the Cairo Symphony Orchestra, led by conductor Mohamed Basha. Farag completed his MMus (Composition) thesis for orchestra "Nashaz" in 2010, supervised by Music Research and Composition Department faculty member Peter Paul Koprowski.
Mohamed-Aly Farag, MMus'10, is a violinist and composer based in Cairo, Egypt and working full time in section 1st violin of the Cairo Symphony Orchestra. Compositional accomplishments include his MMus thesis: “Nashaz” for Orchestra Sonata for Flute and Piano (performed in the Cairo Opera House); Antonín Dvořák International Composition Competition, 2012, Prague, Czech Republic, 3rd prize winner senior category Zvi Zeitlin Memorial International Composition Competition, U.S.A. 4th prize winner. | 2019-04-21T14:17:30 | http://music.uwo.ca/news/2016/mohamedaly-farag.html |
After the great success of the first edition of Fashion Mavericks during London Fashion Week, February. Plans are already in full swing for September (17-18th September) 2010.
Listed on the official London Fashion Week Website, Fashion Mavericks returns in September 2010.
A number of buyers, press, bloggers and key fashion personnel were present. Located just two minutes away from Somerset House, Fashion Mavericks is the ideal place to be, to reach out and be seen and heard during one of the most busiest times of the fashion calender. | 2019-04-19T22:14:15 | http://ethicalfashionforum.ning.com/profiles/blogs/fashion-mavericks-returns-to |
With many years’ experience specialising in disputes within the financial services sector, Healys Dispute Resolution team can advise on all banking and financial services disputes. We have a comprehensive understanding and broad knowledge of numerous sophisticated financial products, and can assist in resolving disputes in this increasingly complex sector.
As well as offering advice on financial disputes, we also offer guidance on risk management, providing commercial solutions that prevent or mitigate potential disputes, and reduce future exposure to risk. | 2019-04-21T04:28:01 | https://healys.com/services/dispute-resolution/financial-disputes/ |
Will I have the opportunity to assign a third party sub license within my 4D Area?
What the 4D Master Franchise program is looking for?
What kind of location should I look for my 4D Master Franchise?
Which is the length of a 4D Master franchise agreement?
Subject to 4D management approval, 4D will grant the Master franchisee the right to third-party operations within your exclusive 4D Area.
How long will it take to initiate my 4D Master franchise?
How much does it cost to obtain the exclusive use of a 4D Area? | 2019-04-25T18:16:49 | http://www.gelateria4d.it/will-i-have-the-opportunity-to-assign-a-third-party-sub-license-within-my-4d-area-.html |
Learn more about AppleCore Solutions Events, Services, Programs, and Courses!
Does AppleCore Solutions work with different types of organizations?
Yes, we work in different stakeholders in the community, including corporations, businesses, schools, entrepreneurs, churches, families, and individuals who are looking to improve in communication, relationships with customers, leadership, and performance.
Does the AppleCore Solutions offer educational pricing?
Yes! We offer discounts to the staff, faculty, and students of any educational or leadership organizations. Visit our Course Catalog to make a purchase or for current pricing information.
How do I contact AppleCore Solutions for support?
For most of our services, programs, and courses, detailed information is available on the pages specific to each service. You can use the navigation bar at the top of this page to visit the appropriate section. If you'd like to contact us please use the the HelpDesk button or visit the appropriate support section for the email address [email protected] to use.
If you're still not sure, just send us an email to [email protected] and we'll be happy to help. A person sometimes ask whether we want one email with lots of items, or lots of emails with one item each. We have a slight preference for the latter, but realistically, we'll take your feedback however you'd like to send it; you're doing us a favor, after all!
Weekdays from 10am to 4pm Eastern time, you can also get phone support by dialing 561-351-9338.
How do I download my assignment and/or worksheet from www.applecore-solutions to my computer?
Just click on download and enter into a folder on your new computer and you should be good to go! If you do not have a copy of your assignment/worksheet which includes your information, you can have your it emailed to you via our customercare@applecore-solutions. Also, make sure you are using the same code as in your email. Click the Course page for more product information.
How do I retrieve my course?
If you purchased the course using our online store, just visit the Course page and enter the information that the page asks for. If we can locate it in our database, we'll send your code to you ASAP.
If you purchased the course at event, the HelpDesk page should also be able to provide you with your code. Otherwise, please contact us at [email protected] for further assistance.
I purchased a service, program, course, or session from the webssite. How do I know I am registered?
Registering for your services, programs, courses, or sessions purchased at an event or online or that came bundled with your special offer is easy! If you have any questions, please contact [email protected]. Registering ensures that we are able to provide you with future information, and also enables us to remind you of your code should you misplace it.
I sent in a question/bug report/feature request via email. How soon can I expect to get a response?
We do our best to respond to all inquiries by the end of the following business day at the latest. We often respond more quickly than that, and sometimes it takes us a bit longer. Our first priority will always be to respond to mail from our customers who have purchased services, programs, courses or sessions.
Try entering the login and/or passcode again, double-checking that the information and/code is exactly correct, with no spaces, tabs, or other characters added to either end. Next, double check that you're not trying to enter a previous code into the line. If those don't work, send email to [email protected] and we'll be happy to be of assistance.
Where can I find answers about The AppleCore Solutions online store or the purchasing process?
If you send an email to [email protected], we'll be happy to help! If at all possible, you'll want to include your order number (look at the order confirmation email we sent you) in the email you send. If you haven't ordered yet, don't worry; just send your question and we'll be happy to help. | 2019-04-25T12:11:14 | https://applecore-solutions.com/faq |
The U.S. Air Force is proposing up to 10,000 F-16 fighter jet "sorties" a year over the Gila and Aldo Leopold Wildernesses and Gila National Forest in southern New Mexico. The area’s wild character would no doubt be harmed by the invasion and noise of these countless military overflights, including those just 100 feet above the ground, and the flares and chaff they will drop.
Aldo Leopold is turning over in his grave. His visionary proposal for a wilderness area in New Mexico’s Gila National Forest came to fruition in 1924, when the Forest Service administratively designated it the world’s first wilderness area, the Gila Wilderness, four decades before the Wilderness Act designated the area by statute. Leopold could not have known that this beautiful, rugged land, meant to be protected in perpetuity, would be under attack almost a century later.
Holloman Air Force Base in Alamogordo, New Mexico, is proposing to expand its military training airspace over the Gila and Aldo Leopold Wilderness Areas, Gila National Forest, and surrounding rural communities. It is planning 10,000 F-16 fighter jet overflights per year, with 10 percent to be flown at night, 10 percent supersonic, and an unspecified number at very low levels, down to just 100 feet above the ground.
Holloman’s proposed action includes the dropping flares and chaff, designed to create an “electronic cloud” to prevent radar detection. Flares allegedly burn out far above ground level, but there are documented cases of them being mistakenly released at low altitudes, reaching the ground and igniting fires. (A 2007 New York Times article reports a New Jersey wildfire started by a flare dropped by an F-16, necessitating the evacuation of more than 2,500 residents).
On July 11, 2017, seven wildfires were ignited on state and federal lands in southeastern Oregon; state and federal agencies are investigating whether those fires were caused by military training exercises conducted that day. Concern about wildfires runs high in communities adjacent to the Gila National Forest, where the 2013 Whitewater-Baldy Fire, the largest wildfire in the state’s history, burned almost 300,000 acres. Add drought and climate change to a long-lived burning flare, and you have a perfect recipe for a conflagration.
Chaff bundles contain up to 5,000,000 aluminum-coated glass fibers up to two inches long, designed to stay airborne as long as possible and settle to the earth after several hours. Military studies on the effects of chaff on wildlife, humans, and water quality leave many questions unanswered. For example, does inhaled or ingested chaff impair wildlife and livestock health? When chaff lands in rivers and streams, does it affect aquatic life and water quality?
Numerous studies document that aircraft noise, especially from supersonic flights, has serious health impacts on humans and wildlife alike. Many hikers have experienced military aircraft that seem to come from out of nowhere, causing one to reflexively hit the deck in self-defense. When our heart rates settle down, we recognize that we are not under attack, but animals have no such realization, and may experience increased stress, and, as a result, decreased feeding and breeding success.
Opposition to Gila flyovers is not a narrow-minded position of not-in-my-backyard. The Gila Wilderness is, to borrow a Ken Burns phrase, one of America’s best ideas. Its wild character would no doubt be harmed by the invasion and noise of countless overfights, including those just 100 feet above the ground, the flares, and the bundles of chaff, not to mention the potential human-ignited fires that may result from inappropriately released flares.
As wilderness historian Roderick Nash said, “Take away wilderness and you take away the opportunity to be American.” While military flights don’t technically “take away” wilderness, that may be the end result.
When the wilderness is no longer a quiet refuge, where do we go to escape the noise and stress and insanity of urban life? This is more than a rhetorical question, and opposition to military flights over the Gila is decidedly not an anti-military stance. Holloman Air Force Base already has ample protected airspace in which to practice military maneuvers, provided by nearby White Sands Missile Range (3,200 square miles), Fort Bliss Army Base (1,700 square miles), and two existing Military Operations Areas.
Holloman Air Force Base did a very poor job – whether intentionally or not – of informing Silver City and surrounding communities about its proposed action, and held its public meetings in towns largely unaffected by the overflights. By the time the conservation community in Silver City (the largest town in the affected area at almost 10,000 residents) learned of Holloman’s proposal, the comment deadline had already passed. Local outrage and a request from concerned county commissioners persuaded an Air Force representative to attend a public meeting, at which very little information was revealed. Subsequent Freedom of Information Act requests resulted in similar opacity, as page after redacted page told us nothing.
Holloman Air Force Base is scheduled to release its draft Environmental Impact Statement (DEIS) in late spring or early summer, when there will be opportunities for public input.
Sign a petition opposing military flights over the Gila.
Please help keep Aldo Leopold’s legacy alive, and let him rest in peace once again. | 2019-04-24T03:52:52 | https://wildernesswatch.org/world-s-first-wilderness-area-under-attack |
At Swift Basement Systems, we're ready to meet all your standards when it comes to Basement Systems in Marion Junction, AL. Our workforce of qualified contractors can offer the expertise you need with the most advanced technology in the market. Our products are always of the finest quality and we have learned to conserve your costs. Contact us today by dialing 800-630-5750 and we will be ready to look at your plan of action, reply to your questions, and arrange an appointment to get started with organizing your task.
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Saving cash is an important part of any mission. Still you need to get high standard results for Basement Systems in Marion Junction, AL, and you're able to depend on us to help you save money while continuing with offering the best quality services. You can expect the highest quality while still costing you less. Our aspiration is to guarantee that you receive the best quality materials and a job that holds up throughout the years. This is possible because we know how to save your time and funds on materials and work. If you want to get lower rates, Swift Basement Systems is the service to contact. Our company is ready to take your call at 800-630-5750.
Basement Systems are available in Marion Junction, AL.
You will need to be well informed on the subject of Basement Systems in Marion Junction, AL. We will not let you come up with imprudent choices, since we understand what we're working on, and we ensure that you understand what to expect with the project. You will not face any unexpected situations if you deal with Swift Basement Systems. Begin by dialing 800-630-5750 to go over your venture. In this phone call, you will get all your questions addressed, and we can schedule a time to start work. We are going to work closely with you throughout the whole project, and our crew can arrive promptly and ready.
There's several reasons to pick Swift Basement Systems when it comes to Basement Systems in Marion Junction, AL. We have got the highest customer service scores, the best products, and the most sensible and efficient cash saving solutions. We're ready to serve you with the most competence and experience available. Contact 800-630-5750 when you require Basement Systems in Marion Junction, and we will work with you to successfully complete the project. | 2019-04-23T22:34:09 | https://www.swiftbasementsystems.com/al/basement-systems-in-marion-junction/ |
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Non numerical (descriptive) service name is not supported. | 2019-04-19T07:23:00 | https://developer.brewmp.com/reference/api/brew-mp-102/aeeclsidaddrinfo |
Coming soon! The SHIFT resource guide for anyone going to the burn or running a camp.
We are pulling all of our notes together from more than 20 years of burning to put all of our lessons, tips and tricks to a rewarding burn out for all to see!
Please donate generously to the culture you enjoy and help create.
Donations over $5,000 may be made by direct deposit.
THANK FOR YOU FOR ALL OF YOUR SUPPORT! | 2019-04-24T16:18:51 | http://shift-bm.com/resources/ |
Trust is the foundation of the relationship between software and its users. Failure to protect sensitive customer data can have a lasting impact on a business's reputation and their bottom line.
But when businesses follow security best practices, they are uniquely positioned to create safe, forward-thinking user experiences—and many of them are doing just that.
In this guide, you’ll learn how to secure your engineering team’s processes and provide the flexibility they need to do their best work. We’ll also address the unique regulatory and technical challenges that software companies face and how GitHub can help. | 2019-04-26T08:05:57 | https://resources.github.com/whitepapers/Secure-software-development-strategy-essentials/ |
Show your pride with this Sublimated Series colored enameled US Army tie bar.
The large 7/8-inch die struck, two piece construction features a sandblast polish finish with silver tone (rhodium) plate on the Army emblem. The silver tone (rhodium) plate deluxe spring tension tie bar secures the clip in place.
This product is an officially licensed product of the Department of the Army. | 2019-04-26T12:07:29 | https://www.ourdesigns.com/store/product.aspx/productId/27051/Son-Sales-Sublimated-US-Army-Tie-Bar/ |
Benefits of the new campus are expected to include: environmental and cost advantages; expanded engagement opportunities with universities and innovative, technology-based companies; an enhanced ability to recruit new employees; and proximity to NGA’s data facilities and current and future workforce.
For more information on the project visit www.nextngawest.com.
Led by St. Louis-based McCarthy Building Companies, Inc., the McCarthy HITT team is responsible for supporting the mission critical needs of USACE and the NGA. McCarthy HITT is a joint venture of the nation’s most capable design-build/operations and maintenance firms. The team includes HITT Contracting, Falls Church, Va.; Black & Veatch Special Projects Corp., Overland Park, Kan.; Gensler, San Francisco; and Akima, LLC, Herndon, Va. The Black & Veatch-Gensler Joint Venture serves as the Architect-Engineer of Record for the project. | 2019-04-20T13:04:57 | https://www.mccarthy.com/insights/mccarthy-hitt-details-preliminary-plans-construction-next-nga-west-project-north-st-louis |
Tower Property Resources, LLC opened in 2002, as an extension of our Green Valley office, which has been in business since 1985. It now stands on its own as one of Tucson’s premier property management service companies.
www.TPRofAZ.com and www.TowerHomeRentals.com . We feature all of our properties on the web along with user friendly forms, contracts, service phone numbers, landscaping tips for tenant and owners to avoid HOA issues and Tucson amenities.
Equal Housing Opportunity. All Content and Images Copyright © 2011 Tower Property Resources, LLC. | 2019-04-19T18:35:53 | https://www.towerrealty.com/about-us/ |
BAGHDAD, Nov 7 (Reuters) - Iraq asked Kuwait Energy to acquire shares of Turkey’s state-owned TPAO in its exploration block 9 oilfield after Iraq’s cabinet decided to expel the Turkish company from the project, a senior Iraqi oil official said on Wednesday.
The measure will mean the Kuwait Energy will hold 70 percent of the project and Dragon Oil PLC 30 percent. TPAO holds a 30 percent stake in the block.
“The cabinet rejected the approval of Turkey’s TPAO as a partner,” Abdul Mahdy al-Ameedi, head of Iraq’s contracts directorate, told reporters.
He refused to give any reason for the decision, but the explusion comes at a time of political tensions between Baghdad and Ankara after Turkey accused Iraqi Prime Minister Nuri al-Maliki of siding Sunni Muslims. | 2019-04-24T08:36:30 | https://af.reuters.com/article/commoditiesNews/idAFL5E8M74UN20121107 |
Stop turn tail, fender mount, strip lights, and multi function lights are all in stock. We have a huge inventory of every type of light. If we don't have it for you to buy today, we can order it for you!! Please visit our showroom so you can see the lights and how bright they are for yourself. We pride ourselves on quality products that will last for many years!! | 2019-04-23T12:10:32 | https://pinklightning.com/collections/dual-function-lights |
This week we Orthodox Christians celebrate the Feast of Epiphany (January 5th–6th). On this feast, we remember when St. John the Baptist baptized our Lord Jesus Christ in the Jordan River (Matthew 3:1–17).
He identified himself with our sinful human condition, which needed to be cleansed.
He made holy (or, sanctified) the waters of the River Jordan, and thereby, all of creation, when His own holy body entered the earth’s waters.
He revealed the Holy Trinity: the Father, who spoke from heaven saying, “This is my beloved Son, with Him I am well pleased.”; the Holy Spirit, who descended upon Him in the form of a dove; and He himself, the Son of the Father.
In the season of this joyous feast, it is the practice of Orthodox Christians to invite their parish priest into their homes, and have him bless their habitation with holy water that had been sanctified during the church services on the feast day. In this way, members of the church participate in the renewal of creation effected by our Lord.
So, during January I’ll be making my “house calls” to parishioners and bringing you all the blessing of the Holy Trinity, demonstrating that you too are part of a new creation in Christ Jesus (2 Corinthians 5:17).
I look forward to seeing you! To help you prepare your household for my visit, I’ve jotted down a few notes, below, and I’ve included a tentative schedule as well.
1. Prepare a table with a clean tablecloth, a candle, and an icon.
2. Provide a bowl with Holy Water that you brought home from church.
3. Provide a list of the LIVING — names of members of your household, along with others you wish remembered during the short service.
4. Please provide a list of the DEPARTED — names of your departed loved ones you wish remembered during the short service.
5. When the priest arrives, please gather your family in front of the table with the icon.
6. Please turn off all radios, TVs, stereos, cell phones, etc.
7. Please close off any rooms you do NOT wish Fr Steven to bless.
8. You may use the Epiphany Hymn offered below to join in with the singing.
The worship of the Trinity was made manifest!
And called Thee His Beloved Son!
NOTE: I will provide an icon and/or Holy Water if you cannot provide them.
← View Our Christmas Concert 2015: Joy to Our Neighborhood! | 2019-04-19T02:17:23 | https://holyghostbpt.org/2016/01/03/epiphany-schedule-for-house-blessings/ |
myTamilDate.com is the best place to meet Tamil singles from your city and around the world. We're responsible for countless marriages and meaningful relationships around the world. Join for free! | 2019-04-23T04:50:14 | https://tamilculture.com/user/mytamildatecom |
Greetings! In this post you will find Filmmaking brother Joel or Ethan crossword clue answers and solutions. This crossword clue belongs to Crosswords with Friends October 17 2018. If there is anything wrong with the answers we have provided for you, please make feel free to contact us so we can resolve the issue you're having problem with. Crosswords with Friends is now part of Zynga Inc and it has changed it's name from Daily Celebrity Crossword.
Already found the answer for Filmmaking brother Joel or Ethan? Go back and see the other clues for Crosswords with Friends October 17 2018 Answers. | 2019-04-21T18:53:13 | http://crosswordswithfriendsanswers.com/filmmaking-brother-joel-or-ethan/ |
Authorities are investigating after a man was shot by a passenger in his car around noon Thursday, according to New Haven police.
Investigators arrived at the Hess Gas Station at 1331 State Street in New Haven to find that a 31-year-old East Haven resident had been shot in the leg and pistol whipped, according to police.
Authorities said the incident happened the Warren Street cul-de-sac.
The victim told police he had gotten into an altercation in his car with the person who shot him, and was shot while the suspect was still in his vehicle. Police said the victim reversed down the street to get away, at which point the suspect fired another shot through his windshield.
The victim was taken to Yale-New Haven Hospital for treatment of non-life threatening injuries, police said.
Police have not identified a suspect. | 2019-04-20T04:57:05 | https://www.nbcconnecticut.com/news/local/Passenger-Shoots-Driver-in-New-Haven-Police-270369071.html |
Today, Judge Tatel with the United States Court of Appeals, issued the opinion of a three judge appeals panel concerning LaRoque, et al., vs. Holder, et al. The ruling overturned a district court, which stated that the plaintiffs did not have standing to bring the lawsuit, among other statements.
In a November 2008 referendum, the residents of Kinston, North Carolina, voted by an almost two to-one margin to switch from partisan to nonpartisan elections for mayor and city council. Absent section 5, Kinston’s city council would have had a duty under North Carolina law to amend the city’s charter to implement the referendum. But since Kinston lies in Lenoir County, a covered jurisdiction, it may not implement the referendum until precleared by federal authorities. | 2019-04-19T19:08:27 | https://bjmurphy.org/us-court-of-appeals-overturns-decision-on-nonpartisan-lawsuit-vs-eric-holder/ |
December 11 - Obtained Larry Murphy and Peter Taglianetti from Minnesota for Jim Johnson and Chris Dahlquist.
December 13 - Obtained Jiri Hrdina from Calgary for Jim Kyte.
December 21 - Obtained Scott Young from Hartford for Rob Brown.
March 4 - Obtained Ron Francis, Ulf Samuelsson and Grant Jennings from Hartford for John Cullen, Zarley Zalapski and Jeff Parker.
June 16 - Obtained Joe Mullen from Calgary for a second round choice in the 1990 Entry Draft.
October 27 - Obtained Gord Roberts from St. Louis for future considerations.
• Bob Johnson was hired as head coach and Scotty Bowman named director of player development and recruitment on June 12, 1990.
• Mario Lemieux returned to the Penguins lineup on January 26 at Quebec after missing 50 games with a back injury.
• Penguins won their first-ever division title, capturing the Patrick Division crown with a 7-4 win at Detroit.
• The Penguins won their first-ever Patrick Division Playoff Championship by beating the Washington Capitals.
• The Penguins earned the right to play for the Stanley Cup, beating the Boston Bruins, 4 games to 2, to capture their first Wales Conference Championship.
• With an 8-0 victory over Minnesota, the Penguins became Stanley Cup Champions, defeating the North Stars four games to two.
• Lemieux won the Conn Smythe Trophy as playoff MVP.
• Jaromir Jagr was named to the NHL All-Rookie Team. | 2019-04-24T08:04:21 | https://pittsburghhockey.net/penguins/seasons-in-review/pittsburgh-penguins-1990-91 |
Huawei on last Monday launched the upgraded version of the old pal Huawei Ascend Mate phablet. This launch took place at the CES 2014 event. Being called as Ascend Mate 2 4G, the phablet bears the same 6.1inch HD LCD screen with IPS technology as its predecessor. However in terms of other specs and configuration, Ascend Mate 2 4G is definitely upgraded version.
The newer Huawei Ascend Mate’s price is still not disclosed and there are no words on the availability of the phablet as well. It is being termed to be coming with Android 4.3 out of the box and thus is pretty much assumable that it will getting the Android v4.4 upgraded rolling out sooner or later. The only thing mentioned about Ascend Mate 2 4G was that this will unlike its predecessor be available in the US, apart from 40 other markets.
Huawei Ascend Mate 2 4G price Specifications and features.
Huawei Ascend Mate 2 4G comes packed up with a 1.6GHz quad-core processor with Snapdragon 400 MSM8928 chipset. It also features an Adreno 306 GPU (Graphics Processor Unit) along with 2GB of RAM. Android 4.3 is customized via layering it by Huawei’s Emotion UI 2.0 skin on the top.
Ascend Mate 2 4G features a 13MP autofocus camera with HDR feature. It also comes with a 5MP front camera. Talking about new Ascend Mate’s internal memory, it comes with 16GB of inbuilt memory which is double the previous model.
Ascend Mate 2 compared to the previous Ascend Mate is slightly thinner, a bit heavier, and is LTE capable with up to 150mbps download speed and up to 50mbps upload speed. Though Huawei Ascend Mate features the same 4,050mAh battery but if company’s words are to be believed, this time it would be accounting of 2 days battery backup. A reverse charging feature has also been included which lets you charge other devices from Huawei Ascend Mate 2 4G phablet. | 2019-04-22T08:43:15 | http://www.geekygadgetworld.com/4596/huawei-ascend-mate-2-4g-price-specs-features/ |
Application Numbers CUP16-0002 and D16-0008: Leprino Foods Silo Expansion at 2401 N. MacArthur Drive – Applicant is E.A. Bonelli & Associates and Property Owner is Leprino Foods– The proposal is to demolish approximately 6,800 square feet of building area and replace it with seven processing silos enclosed by an approximately 50-foot tall screen wall and associated landscaping at the northeast corner of the Leprino Foods processing plant. The project is categorically exempt from the California Environmental Quality Act pursuant to CEQA Guidelines Section 15332 pertaining to in-fill development projects. The Project Planner is Kimberly Matlock, Associate Planner, (209) 831-6430, [email protected].
Application Number CUP16-0003: Proposed Fitness Training Facility – Applicants are Schack and Company and Property Owner is CDN-CBN Partnership– The proposal is to establish Royal Gymnastics and Sports Academy, a gymnastics/sports recreational use, in the building located at 2151 N. Tracy Boulevard. The project is categorically exempt from the California Environmental Quality Act pursuant to CEQA Guidelines Section 15301 pertaining to existing facilities. The Project Planner is Nash Gonzalez, Contract Planner, (209) 831-6443, [email protected]. | 2019-04-25T20:12:06 | https://www.ci.tracy.ca.us/?navid=6686 |
I purchased * tickets to go to Catalina Island because it was labled "valid any day". So in order to make reservation, I viewed all my vouchers to get the codes. However, on the only day I was available, the boat was full, therefore I couldn't use the codes. Because it didn't work when they said it was available ANY DAY, I want to be refunded of my purchase. I couldn't find a way to get the refund (maybe because I opened the vouchers), but I did not use the codes and am not planning to use those codes in the future. I would like a full refund on the * tickets that I purchased and could not use due to the problems of groupon (or Catalina island).
GetHuman-shinhsun did not yet indicate what Groupon should do to make this right.
We are waiting for GetHuman-shinhsun to fix the problem and share the solution with the rest of us customers.
GetHuman-shinhsun indicated the issue is not fixed yet. | 2019-04-22T10:53:23 | https://gethuman.com/issue/Groupon/44Ao/I-purchased-tickets-to-go-to-Catalina-Island-because-it-was-labled-valid-any-day-S |
wininit.exe is a application which is probably legit. So, if wininit.exe is on your system, it is probably ok, and will NOT cause problems. Even if your PC is virus-free, we still advise you to purchase a good antivirus with a good track record, in order to defend your PC against potential security problems.
This program is usually found in C:\Windows\System32\wininit.exe.
The MD5 fingerprint for this file is 4e20895e641f2c3e68ab3db91a1a16f1.
64-bit code has been detected. This exe can use the full power of a modern computer cpu.
wininit.exe has a digital signature. Nowadays the large majority of legit programs are digitally signed.
The digital signature extracted from wininit.exe verifies as ok. This is very good. | 2019-04-21T02:59:58 | https://www.orange-defender.com/wininit_exe-virus-scan-4085-41d5895e641f2c3e68ab3db91a1a16f1.htm |
ABOUT THE UNIVERSITY & THE COMMUNITY: Founded in 1883, the University of Sioux Falls is a Christian, Liberal Arts University affiliated with the American Baptist Churches, U.S.A., with a total headcount of approximately 1500, including undergraduate and graduate students. USF is inclusive of all denominations with dozens represented on campus. Our mission is to foster academic excellence and the development of mature Christian persons for service to God and humankind in the world. Our motto is Culture for Service. We strive to nurture our students’ relationships with God and to build their characters. We offer more than 80 undergraduate programs and the following graduate and adult-learning programs that are offered on campus or online: Accelerated Nursing, Degree Completion Program, Education Specialist, Master of Business Administration, Master of Education and RN-to-BSN. The University is a member of both the Council of Christian Colleges and Universities and the Council of Independent Colleges. USF is accredited by the Higher Learning Commission. USF is also accredited by the following: South Dakota Division of Education and the Council for Accreditation of Educator Preparation (CAEP), Council on Social Work Education (CSWE), International Assembly for Collegiate Business Education (IACBE) and Commission on Collegiate Nursing Education (CCNE). USF is a member of the NCAA Division II and competes in the Northern Sun Athletic Conference (NSIC). The University of Sioux Falls is located in the heart of Sioux Falls, South Dakota, a progressive and respected center for health care, banking and agriculture. The Great Plains region, with its beautiful landscapes and rich agricultural land, enjoys economic and cultural vitality. The city boasts a multitude of recreational opportunities including parks and paved bike trails along the Big Sioux River. The city of Sioux Falls is South Dakota’s largest city with a growing population of 171,544 people, and a metropolitan area of over 240,000. It has been recognized in the national press as one of the nation’s top cities in which to live.
APPLICATION: Applications will be reviewed immediately; however, applications must be complete in order to receive full consideration. Applicants should send a letter of intent, resume or curriculum vitae, official transcripts of all graduate work, three letters of recommendation, and a statement of teaching philosophy and a personal faith statement. Successful applicant’s contract will begin September 1, 2017. Send applications to: University of Sioux Falls Vice President for Human Resources – Computer Science Faculty Search 1101 W. 22nd Street Sioux Falls, SD 57105 Or send materials to: [email protected] For complete application materials received, applicants will be contacted if there is interest in candidacy. The University of Sioux Falls is an Equal Opportunity, Affirmative Action Employer. | 2019-04-22T00:12:29 | http://academicjobsonline.org/ajo/University%20of%20Sioux%20Falls |
This post is kindly sponsored by TÉLIO, and the fabric was provided to me for this project. Thank you for supporting the brands that support this blog.
I used to think sewing basics was the last thing I wanted to do. I just wasn’t jazzed about the idea of tees and comfy pants, especially knowing there’s lots of perfectly good t-shirts and comfy pants out there waiting for me to buy – saving me the time I would spend making them. Turns out, the basics are just like everything else I sew because I can’t find a well-fitting or quality or pretty equivalent in retail, and they can be just as fun to make. I think my hang up for the longest time was that I just wasn’t inspired to make some the basics. It felt, well, basic. But I think an interesting thing happens on the sewing road to Handmade Wardrobe town: you start wearing everything you make and you become acutely aware of what may be missing. Plus, I think sewing becomes more fun the longer you do it, and the new projects keep the love alive.
I wanted to create a collection with TÉLIO this year that really focused on options and a handful of garments that could easily be mixed and matched. So today’s looks lay the foundation for that, even if the tee is next level with some added sparkle. An added bonus of today’s looks is that everything is so quick and easy to make. I will happily invest some serious time into my sewing projects, but I’m definitely not upset about a few speedy makes every now and then.
I made three pieces using a rayon/nylon blend ponte knit, which is considered a stable knit. You’ve seen me use this fabric before, and for good reason: it is a dream to work with, and it’s on the more substantial side in the knit category. It’s a bit beefier so you don’t have to worry so much about all the lumps and bumps showing. I’ve never felt like I needed to wear spanx with any of my ponte knit garments. It’s soft and smooth, has excellent recovery, and doesn’t pill like many polyester ponte knits.
This ponte knit (along with all the other fabrics I’m using) is available at Stone Mountain Fabrics. It’s listed as blue, but the name of the color is actually “teal peel.” It’s mostly navy, but there is a hint of teal, so just know that if you grab some.
I embellished the tee with Swarovski crystals, and I used E6000 glue to apply them. This was my first time using this glue (it’s the one specifically for gems and beads), and it is incredible. Those crystals are never coming off!
I didn’t make any adjustments to any of these patterns. I cut the tee in a medium, pants in a large, and the cardigan in a medium. I might could have sized down on the pants, but I’d rather they be a little roomier than too tight.
I used a stretch 90 needle, all-purpose polyester thread, and the stretch setting on my sewing machine for the majority of the sewing for these pieces. For the edgestitching around the neckline of the tee as well as the hems and the hem of the pants I used a straight stitch and Coats & Clark stretch thread. I went with a blind hem on the cardigan. I serged all the seam allowances.
I’m thinking about a swayback adjustment for the tee, but otherwise I really, really love the fit of all these patterns. All of them will be repeated, and I’m actually thrilled to have a quality tee pattern. I may chop the pants off to be culottes, but I’m still thinking about that. (I have culottes on the brain lately!) It’s too hot here to wear them right now, but even in winter I’m much more likely to wear those as culottes than full length pants. I’ll keep you posted.
And just a reminder: next week is intermission so there won’t be any new posts for this TÉLIO project. We’ll pick back up the second week of September with the last looks and a lookbook of all the outfits mixed and matched together. Looking forward to it! | 2019-04-24T08:06:38 | https://www.telio.com/category/telio-collaborations/page/2/ |
Thanks to Multicom Entertainment, we’ve got an exclusive clip from the new drama film The Broken Ones, which is directed by Elyse Niblett-Russell from a script by star Cece King (Jessica Jones), which is based on King’s struggle to cope with the loss of her father in the 9/11 attacks.
Two troubled strangers meet one night and help each other overcome personal fears and tragedies.
The Broken Ones is set for release on July 10th and stars Cece King, Charlie Bewley, Meg Donnelly, Constance Schulman, Margaret Colin and James Russo.
The post Watch an exclusive clip from The Broken Ones appeared first on Flickering Myth. | 2019-04-21T03:41:16 | https://m.imdb.com/news/ni62122168?ref_=m_nm_nwr1 |
Tashelle has been in the veterinary field for 16 years. She has experience as an animal attendant, receptionist, technician and manager. She has lived in many different places in the states, from Hawaii, Texas, Virginia, and North Carolina. Tashelle has been back in Canada for five years now where her family lives. When she isn’t working, she is loving beaches, boating and spending time with her three dogs, King, Liena and Ewa. | 2019-04-20T20:47:41 | https://www.grahamanimalhospital.ca/about-us/team/tashelle/ |
Business is the broad term that is included numbers of aspects in it. Starting a new business is one of the daunting tasks. There are numbers of factors those are affected by the business directly or indirectly such factors are political, economic, environmental, social, financial and many more.
Financial factor is one of the greatest factors, and it has much more value to the business. However, you are going to start a new business or are planning to expand an existing one the financial term has the main role to operate business smoothly.
If you are planning to start your own new business, then you have to consider the financial conditions. It is necessary to have the appropriate amount in your account before starting a process for new business. If you have not an appropriate amount in your account, then you can take help from business loans.
If you want to take a business loan, you have to know each and every aspect of business loans. There are numbers of business financing options that everyone should consider all these options before choosing the right one for their business.
All these are particular forms of business financing, read more about credit score repair steps. It would be better to compare the most popular terms each other to choose the best one for the business.
There are many things that you need to know if you want to get success in choosing the best option for you. Well, we are explaining some imperative things that you have to keep in mind that might help you in choose the right option for your business.
Your accounting records and financial statements have much more value in business financing. Make sure that financial statements and account records are clear and have no issues.
Know the different kinds of business loans because there are numbers of business financing options are available. If you want to get the best one,, then you have to determine all kinds of business loan.
There are numbers of service providers for a business loan. It is must to know more and more about them if you want a safe and secure option for your business. So you can take help of the internet to know more about this term.
Previous Previous post: What are the side effects of steroids use? | 2019-04-18T16:25:06 | https://www.macroeconomicwoes.com/impressive-information-about-business-financing/ |
It has been known to happen that, when non-aviation residents speak up to resolve aviation noise problems, they incur the wrath of some of the lower members of the pilot community. Most pilots are better than this, but there are a few who stoop this low.
One apparent example happened a few years ago, near Longmont, CO. After years of increasing noise by the aircraft operating for Mile-Hi Skydiving, Kimberly Gibbs and others had begun to organize, seeking to restore their quality of life. So, Ms. Gibbs became a target. In May 2012, she received a large envelope from Mile-Hi; inside was a tacky homemade poster that read “Have a Great Summer!” Clearly, it was sent just to remind her that the full-throttle months of the parachute season, with the noise that had ruined her previous summers, were just beginning.
Oh, and they also slipped in an ‘I love airplane noise!’ bumper sticker.
Here is a track, based on the actual radar data for N481SH, an Enstrom helicopter based at Vance Brand Airport: And to the right is a series of small images, with screen-captures showing the progress of the flight. Pay close attention to the data blocks, which show a ‘1200’ transponder code (used by ATC to track flights and attach flight data) as well as airspeed (MPH) and altitude (above ground level).
The bottom image shows flight data at position ‘1’ (orange circle on the larger image above), the middle image is position ‘2’, and the top small image is position ‘3’.
The flying was fairly erratic, as indicated by the route, the speed trends, and the altitude trends. At position ‘1’, the pilot was over open space (the green area); he then threw away his safety margin by flying away from the open space and into the residential neighborhood, descending, and averaging a mere 200-feet above ground level!
At position ‘2’ he made a right turn toward the targeted backyard and gunned it, speeding up to make a ‘shock and awe’ appearance at the barbeque (near position ‘3’). The whole party observed the rogue helicopter come to a stop and hover. Then, with his mission complete, the pilot started to accelerate (and slowly climb) to depart position ‘3’ toward the northeast.
…When she told FAA what had happened, they told her that this kind of flying is all ‘legal’, per FAA’s helicopter regulations. | 2019-04-25T01:46:20 | http://aireform.com/airports-atc/faas-airports/klmo/an-example-of-harassment-by-a-helicopter-pilot/ |
Fluffy, sticky, soft, or icy — Pleasant Ridge Plantation’s Bob Howe has a snowshoe for that.
The Rabbit Hunter is one of 12 styles in Howe’s Maine Guide Snowshoes line. Others include a short, light racing shoe that racer Judy Holmes wore to two first-place and one second-place wins at the 2017 Beaver Creek Snowshoe Race Series in Colorado. The nimble Sportsman, with its upturned nose and short tail, is a favorite of surveyors. Montana game wardens and Trans-Alaska Pipeline workers like the 5-foot-long Alaskan Super Shoe, capable of supporting up to 300 pounds in deep powder.
All have a hand-cut ash frame strung with interlaced polymer rope (or traditional rawhide), which Howe says is superior to contemporary aluminum shoes with synthetic decking and crampons. “When you step in the snow and sink, you gotta carry both the shoe and the snow,” Howe says of the latter. “And without the crampons, it would be like walking on a plastic bag — those crampons aren’t there to help you climb mountains; they’re there so you don’t fall down.” Plus, he says, the crampons are often a nuisance, jamming up with snow.
Howe builds and finishes the frames and installs his signature bindings. He hires former Charleston Correctional Facility inmates to tie the webbing. Sales support his not-for-profit Pine Grove Programs, which offers free weekly hunting and fishing trips to military veterans. $235–$280 (excluding bindings).
Maine Guide Snowshoes, 823 Ridge Rd., Pleasant Ridge Plantation. 207-672-4011. | 2019-04-23T20:08:22 | https://downeast.com/big-foot/ |
CNN correspondent Christiane Amanpour was confused by a split screen showing President Barack Obama and Russian President Vladimir Putin — thinking the two men were standing next to each other at an event marking the anniversary of D-Day.
“No, that’s a split screen, Christiane, it’s a split screen,” anchor Carol Costello said back in the CNN studio.
Watch the full video clip of the exchange at Mediaite. | 2019-04-22T10:49:06 | https://www.newscaststudio.com/2014/06/06/split-screen-confuses-cnn-anchor/ |
Are missing anything? if you hear about an event and would like to support your local brewery or business, feel free to contact us.
We're hosting our second annual Fierce Ladies Beer Fest, a craft-beer fest featuring women-brewed beers!
The fierce ladies from all over Washington state breweries dedicated International Womxn's Day to brew up a batch of beer with the YCH Pink Boots Society Hop Blend featuring Loral, Mosaic, Simcoe, Sabro, and Glacier hops!
The beers and the festival will benefit Pink Boots Society, an organization that assists, inspires and encourages women beer industry professionals to advance their careers through education.
Tickets are $27 for 10 tokens (4oz pours in a commemorative glass to take home with you!).
This is an ALL-GENDER event, everyone is welcome to come celebrate some awesome brews from some awesome ladies. We are kid- and dog-friendly, but you do have to be 21+ to partake in the drinking.
Stay tuned for a list of participating breweries and more info!
An annual event to commemorate the week we moved into our new space - ELEVEN YEARS AGO! Once again we're turning over all SIXTEEN front taps to them!
On Saturday, May 11, 2019, To celebrate Seattle Beer Week and raise money for Seattle Children's hospital, Peach & the Pig and Wicked Good Grinders go head to head in a Star Wars themed intergalactic battle for the best cheese sandwich. The 501st Legion and The Rebel Legion will come outfitted as your favorite Star Wars characters to aid fundraising efforts. New to this year’s event is axe throwing. PNW AXE Throwing Company will be there with their axe throwing trailer to host a open session as well as a “Axe Saber” throwing competition. All of the money raised from the “Axe Saber”competition will go to Seattle Children’s. Also a portion of every Cheese War ticket sold will benefit Seattle Children's Hospital.
- A $5 donation for Seattle Children's Hospital.
Come support a great cause and enjoy this cheesy event!
Outdoor Odysseys Sea Kayaking is partnering with award winning Wander Brewing of Bellingham for a multi-day adventure of kayaking, wildlife viewing, and pairing locally crafted beers with delicious camp cuisine; spend three days paddling the San Juan Islands and two nights enjoying local craft beers as our expertly guided sea-kayaking tour by day becomes a waterfront tasting room by night.
The head brewers from Wander will be paddling with us out to Jones Island and setting up a waterfront tasting room of their classic Wanderale, our guide-favorite Dog Lost Pilsner, and hopefully some new summer brews, while you relax on the beach keeping your eyes peeled for orcas, humpbacks, seals, bald eagles and more.
Outdoor Odysseys provides all the kayaking gear, camp equipment, and gourmet meals thoughtfully prepared from local and organic ingredients; all you need to bring are your personal items, love of craft beer, and a sense of adventure.
Outdoor Odysseys Sea Kayaking is partnering with award winning Fremont Brewing of Seattle for a multi-day adventure of kayaking, wildlife viewing, and pairing locally crafted beers with delicious camp cuisine; spend three days paddling the San Juan Islands and two nights enjoying local craft beers as our expertly guided sea-kayaking tour by day becomes a waterfront tasting room by night. Fremont’s head brewers will be loading up our kayaks with cans and crowlers of fan favorites like the Universal Pale Ale, seasonal Summer Ale, and the ModPod - which honors our three pods of Southern Resident orca whales, who might even swim past the west side of the island as you lounge on the beach drinking their namesake IPA.
Friday, April 19th, Gruff Brewing and Atwood Ales celebrate the release of their collaboration ale, “Assistant to the Regional Manager". A Belgian-style saison made with estate-grown beets, the release celebrates two of Whatcom County's two smallest breweries coming together. As Atwood Ales recalls it the conversation started when Atwood Ales volunteered their golden beets, grown on their farm near Blaine, Washington. The result is a beer that imparts earthy notes, inter-played with the soft breadiness provided by the malts, and a balanced bitterness throughout.
Look for this to be released at Gruff Brewing's taproom, just down the street from Boundary Bay Brewing Company & Bistro.
While you're there, enjoy "The Office"-themed trivia for $1 per person (with a maximum of 6 per team), a costume contest, and of course "Assistant to the Regional Manager" on draft. Everything starts at 6 pm with the release of Assistant to the Regional Manager, followed by trivia at 7 pm.
Gruff Brewing is located at 104 E Maple St #101, Bellingham, WA 98225. For more information visit https://www.gruff-brewing.com/.
When describing the origins of a business it can be easy to list the details while losing sight of the excitement that led to them. You can say something about how Gruff Brewing was started in a garage in 2013 by three friends who were born and raised in Bellingham Washington. You can go further into the details by talking about how those same three friends spent their childhood winters plowing through the powder at Mt. Baker together, and spent summers exploring the Pacific Northwest and skating every piece of fresh pavement they could find. But those details don’t describe the excitement that led three childhood friends to spend every free moment they had brewing beer together, the joy of sharing a new creation with friends in a soaking wet garage with the doors open on a frigid February afternoon, or the hope that others will enjoy their beer as much as they’ve enjoyed making it.
Established in 2016 in rural, northwest Washington State, our small, family farm grows ingredients for the on-site brewery where we produce unique ales inspired by French and Belgian farmhouse brewing traditions.
We start with local ingredients: water from our local aquifer; malt from less than 50 miles away in the Skagit Valley; and our estate-grown hops. Then, we add other ingredients sourced from our own farm; gathered and foraged from the peripheries of our property; or purchased from local organic farmers, producers and processors. Finally, we ferment at ambient temperatures, in open tanks, with expressive yeast strains, before packaging and bottle conditioning the vast majority of our beers. Our beers are meant to represent some aspect of time and place, with the ingredients, seasons, weather, microbes and our brewer all having both intentional and spontaneous influences on the flavors of our beers.
Our unique, bottle conditioned and draft farmhouse ales are available throughout western Washington and in limited quantities in British Columbia and Florida.
The Olympic Club Brewfest is back, and it’s a two day event again this year! We're kicking things off on Friday night, so join us to start sampling over 40 handcrafted beers and ciders from McMenamins and guests from the Pacific Northwest, and let the good times roll right into Saturday night.
Take the train! We've partnered with Amtrak Cascades so you could be whisked right to the stop next to the Fest. Look for flyers with Amtrak 2-for-1 vouchers with a code circulated throughout McMenamins.
While our rooms are sold out, we’ve teamed up with the nearby Holiday Inn Express & Suites. Enjoy the Olympic Club’s annual Brewfest and leave the driving to us! Brewfest room rates are based on double occupancy using the promo code OBF. Each reservation comes with 2 tickets to Brewfest, 2 Brewfest glasses and a complimentary shuttle ride to and from Brewfest. It will be $20/person for each person over double occupancy. Make sure to call 360-740-1800.
Co-founder of BR549 and three-time Grammy nominee Gary Bennettgrew up in Texas and Washington State. He received his first guitar and wrote his first songs at eight-years-old. He played bass in a local, traveling country gospel band when he was 16.
He worked as a timber cutter before playing in Portland country bands full time at 25-years-old. He moved to Nashville in 1993 and met Chuck Mead to start BR549. The band travelled the world many times over while recording five albums on Arista Records.
Besides earning 3 Grammy nods, Gary has appeared on countless TV shows such as Conan O'Brien, David Letterman, Nashville TV and more. In 2013 Gary returned to the Pacific NW, bought the home he was raised in and started the Coattail Riders.
Shawn O'Connor grew up in Kelso, Washington and began playing guitar at age 10. He's been a regular on the Portland music scene for over 20-years.
He's worked with Nicolette Larsen, Bobby Bare, Little Jimmy Dickens, Joni Harms and has shared the stage with Randy Travis, Blackhawk, Diamond Rio, Lonestar and Mark Collie to name a few.
Rudi Spain bass player worked with such notable Portland bands as Buckboard and has been on the Portland music scene for over 30-years.
Celebrating women in brewing by drinking beer brewed by women!
SEATTLE --- Building on the popularity of the Ballard Brewed Winter Beer Festival, the eleven breweries that comprise the Ballard Brewery District have once again joined forces to raise money forBellwether Housing, Seattle’s largest private, nonprofit affordable housing provider.
On Saturday, April 13, Bad Jimmy’s, Hales Ales Brewery, Lagunitas Brewing Company, Lucky Envelope Brewing, Maritime Pacific Brewing Company, NW Peaks Brewery, Obec Brewing, Peddler Brewing, Populuxe Brewing, Reuben’s Brews and Stoup Brewing will come together under one roof, Hale’s Palladium, to pour tastings of their Spring beers and ales. Each will bring two beers,one of which will be released for the first time that day.
Due to popular demand (the Ballard Brewed Winter Beer Festival sold out!), the breweries have chosen to add a second session to the event.
Session one will run from 2 – 4:00 PM and feature music by Honey Mustard.
Session two will run from 5 – 7:00 PM and feature music by the Tall Boys.
Food will be available for purchase at both sessions from Chavoya’s Hot Dogs and Big Mario’s Pizza.
Advance tickets now available at Eventbrite.
Bellwether Housing builds and manages affordable housing that makes opportunity accessible to people of diverse backgrounds. We envision communities where people of all incomes and backgrounds share in the opportunity and prosperity of our region. Bellwether has developed, owned and operated housing for low-income individuals, families, seniors and households transitioning out of homelessness since 1980 --in total, 2,100 units in 32 buildings throughout Seattle serving 3200 people.
The Ballard Brewery District in Seattle is home to eleven craft brewing establishments all within walking distance to one another. Each brewery has a unique and eclectic vibe. From IPA’s to saisons, cask brews to pale ales, blondes to browns, the District has a beer bounty sure to appeal to every beer lover.
Bale Breaker is turning 6! Join us as we celebrate our birthday and let you in on a little something special—and when we say special, we're talking rainbows and glitter and garland and lots and lots of serotonin. We're talking the Imagination Station.
The Imagination Station is our psychedelic playground. It’s a funky, free place where just about the only thing that’s taken seriously is our craft and quality—everything else is fun and games and exploration. A mimosa glitter beer? Why not? We’ve done crazier.
Come for the Glitter Princess Birthday Brüt IPA, stay for the face-painting, balloon animals, and rainbow everything. At The Imagination Station, anything goes. If you can dream it, we’ll at least let you try to do it.
We’re ready to surprise you—so come on over, bring a friend, try something weird, and hop on into the Imagination Station.
This Saturday, 2 days before Federal and State Tax filings are due, Seattle’s Maritime Pacific Brewing Company invites you to take a before April 15th. As Ballard's oldest continually operating brewery, Maritime Pacific Brewing Company will host a dock sale from noon to 4 pm featuring limited-edition bottled beers sold side-by-side with some of your favorites. While you're there, don't forget to stop into the brewery's Jolly Roger Taproom to scarf down Jolly Royal Beef or Veggie Sliders or a pint of their latest IPA or classic beers.
Seeking clarification on what was for sale, the brewery sent this list which includes 12-ounce and 22-ounce cases.
We here at the Latona Pub have been celebrating Earth Day with a variety of keg walking and sponsorship events for the last 10 years. The goal of our celebration is to raise awareness of our environment, both urban and natural. By remembering how our actions affect the planet, we set out to help some fantastic organizations that work on environmental issues, and remind ourselves what we can individually do to protect our cherished resources.
The core of our celebration is delivering beer to the Latona by non-motorized, emission-free means. We live in a unique place where world class beer is merely a walk, sail, or cycle trip away from a plethora of diverse and innovative breweries. For a full week, our entire tap list comes from these non-motorized deliveries—the longest trek this year will be from Rogue Issaquah, as organized by one of our pub regulars, Miles Boucher.
To locally demonstrate an alternative to fossil fuel delivery, we will also walk multiple kegs via hand truck from south Seattle, Greenwood, Magnolia, Fremont, Ballard, Northgate, the U-District, and Lake City. This year, our walks begin on the 13th from Georgetown, followed by a walk on the 14th from Greenwood. On Monday the 15th, we'll be walking from the U-District, where this tradition began 10 years ago.
Wednesday, the 17th, we'll be touring the Ballard brew scene with the Highball String Band fiddling along the route, in a walk supported by Feet First, an organization dedicated to improving the urban walking experience in Seattle. We'll be hosting our annual benefit for them at the Latona the same night at 7pm, with live music and a live auction.
Finally, we'll roll through Lake City on the 19th for our final trek to the Latona.
On Saturday, April 20th at 7pm, we'll be throwing an Earth Day celebration benefitting our friends at the Brewshed Alliance, who work tirelessly to protect the watersheds that are essential to producing the wonderful beer we drink. Then, on Monday, April 22nd at 7pm, we'll be hosting the Northwest Bee Association, the Snohomish Bee Company, and Save Our Wild Salmon for an educational night about bee conservation, with musician Andy Coe taking the stage at 6:30pm.
Our Earth Week keg walks have even spread to Tacoma, where our friends at the Edison City Alehouse will be organizing non-motorized deliveries of their own and will also be holding an event benefitting ForeverGreen Trails on Saturday the 20th.
The Latona strives to be a place not only to discuss the future of the planet, but also to foster a discussion about the steps we can all take to affect change. We welcome you to join us during the week to celebrate our planet and highlight these important issues.
Come celebrate our 8th Anniversary with us on April 12th! Starting at 4pm we will be tapping Snow Creek Kolsch and after that Two Lions will be playing. We hope to see you there!
From Session IPAs to Triple IPAs,and all hops in between!
In honor of Skagit Beer Week, Farmstrong, Bastion, Chuckanut, Garden Path, and Anacortes are doing a joint brewers night at the following locations. Come meet brewers and owners of a collection of Skagit Valley brewer’s each with a unique style to showcase. Have flights curated and described by all members, get to know our staff, and possibly win swag.
"Going Under the Knife Night", a benefit for American Brain Tumor Association at Ounces.
Hi friends, Laurel here, owner of Ounces! Hoping you'll join me and our brewery friends to help raise money for a cause very personal to me. I was recently diagnosed with a brain tumor and will be going under the knife (hence the name, lol) on April 3rd to have it removed.
Before the surgery, I'd love for you to come have beer with me and help raise a bunch of money for brain tumor research!
Here's how the fundraiser works: We've partnered with 13 of our brewery friends to raise funds for the American Brain Tumor Association (or ABTA). For 1 night only, both us and the 13 breweries will be tapping up a specific beer and donating $1 of every pint sold (us at Ounces and each of the breweries at their respective taprooms).
So on Thursday, 3/28... head to Ounces or one of the below breweries and lets all drink beer for a good cause!
Next month, on the 23rd of March, Populuxe Brewing will celebrate their 6th year in Seattle's Ballard neighborhood. Inspired by retro game shows, the brewery will entertain you with unique prize contests, limited-edition beers, and even a friendly game of Family Feud between nearby Reuben's Brews and Populuxe Brewing.
From the beginning, the first 20 customers will receive a free commemorative t-shirt with purchase, before being entertained by Betty Wetter. At 5 pm, guests will have a chance to parody the Price is Right, estimating the costs of various with the winner getting a prize. Then at 7:30, teams of four will face off in a mock game of Family Feud, before being entertained as breweries Populuxe and Reuben's Brews compete for best brewery in a special round of the 'Feud.
If you're interested in being a contestant during the party, you can visit Populuxe's Facebook or Instagram page in the coming weeks.
Besides games, Populuxe Brewing will releases three unique India Pale Ales and one sour. Breaking it down, here are the beers.
Finally, the brewery encourages you to leave the cooking to guest food truck, Peasant Food Manifesto, as they serve up TV dinner-inspired recipes with varying prices.
Populuxe Brewing Company is located at 826 NW 49th Street in Seattle, Washington and Retro Game Show Night is sponsored by Verity Credit Union.
Populuxe Brewing was founded in 2012 by husband-and-wife team Peter Charbonnier and Amy Besunder. The brewery offers a variety of rotating taps including IPAs, CDAs, saisons, sours, brown ales and more, and features Ballard’s largest beer garden and an arcade. Populuxe Brewing won Washington’s Small Brewery of the Year award for 2018.
Event is 21+ with valid ID. Please RSVP, however RSVP does not guarantee entry as this is a public event. The venue is a short walk from the Washington State Convention Center and Emerald City Comic Con. We hope to see you there!
This is the first installation of a monthly professional comedy show at the Aslan Depot! We've got world class comedians dropping by to entertain you for just $10!
Our March show is especially exciting because we have comedy from LA-based Portland native Caitlin Weierhauser! Caitlin Weierhauser won Portland Helium Comedy Club’s Funniest Person Competition and was voted Favorite Comedian in the Willamette Week Readers Poll in 2017, they placed in the Top 5 Funniest in 2016. Caitlin came in top 3 at Big Sky Comedy Fest, and has performed for Bridgetown Comedy Festival (2015, 2016, 2017), Bumbershoot, Pickathon, All Jane Comedy Fest, and you can see them in Season 2 of The Benefits of Gusbandry on Amazon Prime!
- Erin Ingle! A Seattle favorite that has performed on Comedy Central Roast Battle.
-Chase Mayers! AKA the Louisiana Slow Burn, Chase recently won Best of the Fest at the Burbank Comedy Festival.
-Travis Nelson! A WWU alumnus and full time comedian now based out of Seattle, Travis recently made the finals of the World Series of Comedy.
Washington Breweries throughout the state are throwing open their doors and letting the public stream in! Stop by our brewery, where you can chat with the brewers and try a sample of their handcrafted brew. You can also get a tour of the brewery and a few stamps for your McMenamins Passport.
Bring your 64-oz. growler and fill it with any McMenamins beer for $9 on this day only! | 2019-04-23T08:01:58 | https://www.northwestbeerguide.com/calendar?category=Washington |
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Last Man Standing - WIN A CAR!
Get your ticket to our Last Man Standing day. Major prize is a Mitsubishi Mirage valued at $15,990 thanks to Cricks Mitsubishi.
Have you signed up for the golf day?
Panthers beat Mayne in their first away game of the season.
Join us as we celebrate the start of the 2016 season!
Presentation to start at 7pm. | 2019-04-24T00:27:29 | http://websites.sportstg.com/club_info.cgi?c=1-109-36640-0-0& |
just another day in paradise: Confident? Not yet.
Bless his heart! I have one like that. Well, except that he hasn't brought me a report card to be proud of yet!
Yay, Kyler!!! You go, Dude!
Hee hee! And why does he have so many tardies??? | 2019-04-20T03:11:08 | http://kylerandkady.blogspot.com/2009/01/confident-not-yet.html |
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This refers to an electronic mailing address to which e-mail may be sent and received. | 2019-04-24T04:48:58 | https://www.primexeon.com/clients/knowledgebase/25/Domain-Names.html |
Court decisions in Italy are not considered a source of law, since courts are supposed to apply existing legislation. However, case law precedents play an important role in shaping Italian employment law.
Legislative Decree No. 81 of 15 June 2015, aimed at regulating systematically the different types of employment contracts (fixed-term contracts, staff leasing, apprenticeships, etc).
Many issues related to employment relationships are governed by the national collective bargaining agreement (CBA) applied by the employer, as well as by those agreements that are signed with trade unions at company level.
The Italian Constitution guarantees equal treatment of all citizens and expressly forbids any kind of discrimination based on birth, race, gender, religion, ideology or any other personal or social circumstance.
Furthermore, direct and indirect discrimination are prohibited. Direct discrimination is where a person is treated less favourably because of one of the prohibited grounds. Indirect discrimination is where an apparently neutral provision, criterion, practice, agreement or conduct would have a disparate impact on one of the protected classes.
It is also unlawful to harass a person, violate his or her dignity or create a hostile, degrading, humiliating or offensive environment because the person is a member of a protected class. Similarly, sexual harassment is prohibited.
The Ministry of Labour and Social Policies is responsible for labour, employment and labour protection policies, the adequacy of the social security system and social policy.
The National Labour Inspectorate (INL) is in charge of carrying out inspections at workplaces and operates throughout the national territory (with the various Territorial Labour Inspectorates), and ensures the implementation of all labour laws and regulations, including health and safety, treatment of disabled employees, etc.
The National Institute of Social Security (INPS) is the social security body, which insures almost the totality of dependent workers in the private sector and, recently, also those in the public sector.
The National Institute for Insurance against Accidents at Work (INAIL) is a public entity safeguarding workers against physical injuries and occupational diseases.
Employment tribunals are public bodies that have jurisdiction over disputes between employers and employees (or claims regarding commercial agencies and independent contractors). Generally speaking, their decisions are appealable to the Court of Appeal, while appeal judgments can be challenged in front of the Supreme Court.
Section 39 of the Italian Constitution provides the freedom to form or to join a trade union. Accordingly, trade unions are considered as unincorporated associations that do not need any authorisation or any registration to be recognised.
Section 14 of the Workers’ Statute also provides that workers have the right to set up trade unions, join them and take part in union activities within the workplace.
participated in the bargaining process concerning the collective agreement (at any level) applied by the company, even if they did not execute it.
The main union organisations within the workplace are the Rappresentanze Sindacali Aziendali (RSA) and the Rappresentanze Sindacali Unitarie (RSU). The main difference between the two is their composition: the RSA is appointed by the relevant unions, and the RSU directly by the workforce.
Legislative Decree No. 113 of 22 June 2012 has implemented Directive 2009/38/EC of the European Parliament and of the Council of 6 May 2009 on the establishment of European works councils.
Works councils have specific powers and rights provided by the law. Collective bargaining agreements may provide additional powers.
co-determination - in order to use monitoring systems that indirectly monitor, or could be used to monitor, the working activities of employees, the employer must follow a specified procedure of co-determination with the employees’ representative.
Section 8 of the Workers’ Statute prevents the employer from investigating, during the employment relationship or for the purposes of hiring, the political, religious or trade union opinions of a prospective employee, as well as facts that are not relevant to evaluate his or her professional aptitudes. There is no difference if an employer conducts its own checks or hires a third party (the same restrictions would apply also to recruitment agencies and other accredited private entities, according to section 10 of Law No. 276/2003).
According to section 5 of the Workers’ Statute, the employer cannot directly check the physical suitability of an applicant. However, before entering into an employment contract with an individual, employers can give medical tests to verify the applicant’s physical capability to perform the duties required for the job, and refuse to hire an applicant that does not submit to the examination.
Employers can also test for drug and alcohol use or addiction, if the employees’ duties involve risks to the security, safety and health of third parties, and refuse to hire an applicant that does not submit to the examination.
Discrimination in general is always prohibited. According to article 16 of the Workers’ Statute, it is prohibited to offer more favourable economic treatment only to a specific group of workers based on the discriminatory grounds described in article 15.
However, some laws provide for ‘positive action’ that must be taken against discrimination, such as the mandatory hiring of disabled employees or employees belonging to the so called ‘protected categories’ (eg, widows, widowers or orphans due to accident at work or war).
As a general rule, there is no obligation for the employment contract to be in writing. However, the written form is required for the validity of certain contracts or covenants (eg, fixed-term employment contracts, non-competition agreements or probationary period clauses) or in relation to the burden of proof (eg, in case of agreements with temporary workers). In any event, the employer must provide, in writing, the employee with certain mandatory information (eg, the identity of the parties, place of work, starting date, duration and probationary period, if any) within 30 days of the beginning of the employment relationship.
Over the years changes to legislation have gradually simplified the formal requirements for hiring fixed-term employees in Italy. According to Legislative Decree No. 81/2015, an employee can be hired on a fixed-term basis, provided that the maximum duration of the contract(s) does not exceed 36 months, including renewals (up to five). The duration clause must be signed in writing.
The 36-month limit can be derogated from under the terms of a CBA.
If the employee is rehired within 10 days of the expiry date of the previous fixed-term contract whose duration was not more than six months, or within 20 days of the expiry date of the previous fixed-term contract whose duration was more than six months, the next contract will be deemed to be an indefinite or open-ended contract (unless otherwise provided for under the applicable CBA).
The number of employees who are employed under fixed-term contracts cannot exceed 20 per cent of the total number of permanent employees of the employer as at 1 January each year (this can be derogated from by the applicable national CBA or by company-level CBAs).
by employers that failed to draft a risk assessment document in accordance with Legislative Decree No. 81 of 9 April 2008.
The maximum duration of the probation period is set out in the applicable collective agreement and varies depending on the level of the employee. In any event the maximum duration cannot exceed six months.
According to the Italian Civil Code, an independent contractor performs a job or a service for consideration, without being under the employer’s control and without being integrated in the employer’s business, while an employee performs an intellectual or manual work activity within the company, under the management and the control of the employer in exchange for a certain salary.
As of 1 January 2016, the rules concerning employment subordinate contracts apply to the consultancy in case of independent workers that provide services that are performed in a manner that is exclusively personal and continuous, and the execution of which is organised by the employer with regards to timing and place of work.
Agency contracts are regulated by Legislative Decree No. 81 of 15 June 2015. Agencies that supply agency workers to user companies must be expressly authorised by the Italian authorities.
Agency employees are entitled to the same ‘basic working and employment conditions’ as comparable employees directly recruited by the user.
The supply of agency employees may be either for a fixed term or for an indefinite period.
Temporary fixed-term contracts can be entered into within the quantitative limits set forth by the CBA applied by the user company.
The number of agency employees who are supplied for an indefinite period to work in a company cannot exceed the threshold of 20 per cent of the number of regular permanent employees working in the same company on 1 January of the year in which the agency employees were engaged.
Users are jointly liable with the employment agency for the payment of agency workers.
Italy’s immigration system varies depending on whether or not the worker is a EU national.
As far as EU nationals are concerned, there are no numerical limitations and they are not subject to specific immigration procedures.
Non-EU nationals intending to work in Italy must obtain a work permit. In this regard, each year the Italian authority sets quotas for the maximum number of regular work permits that may be applied for by foreign nationals from outside the EU. However, highly skilled personnel and other personnel (eg, translators, interpreters, university professors and journalists) can apply to work in Italy irrespective of these quotas, subject to an ‘extra quotas’ procedure.
salaried employees who are regularly paid by employers (either individuals or organisations) that reside or are headquartered abroad, and from whom they receive their salary directly and in cases where the employees are temporarily transferred from foreign countries to work with individuals or organisations, be they Italian or foreign, residing in Italy, for the purposes of performing, in Italian territory, specific services in the framework of contracts executed between the above-mentioned individuals or organisations residing abroad in accordance with the provisions of section 1655 of the Italian Civil Code, as well as international laws and European Union provisions.
Spouses are entitled to work in Italy without having to obtain their own work permit, provided that the family relationship can be proved with official documents.
Italian employers should check that the employee has a work permit. Where an employer employs personnel without a work permit it may be subject to administrative sanctions of up to €5,000 per employee and imprisonment for a period of three months to five years (section 22 of the Legislative Decree No. 286 of 25 July 1998, ‘the Immigration Act’).
A labour market test is not required in Italy.
Normal working hours are 40 hours per week calculated over a period of four months.
Collective agreements may require fewer hours referring to the normal working hours and may also raise the calculation period up to six months, or 12 months in case of objective or technical reasons, or reasons inherent to the organisation of work specified in the collective agreements.
The average working hours cannot in any case exceed 48 hours, including overtime, in each period of seven days.
Employees are entitled to a daily rest of at least 11 continuous hours every 24 hours, between the end of one working day and the start of the next. The number of hours worked per day may not exceed 13, unless the collective agreement or individual company agreement establishes a different working pattern for the day. In all cases, however, the rest between working days must be respected.
An employee cannot opt out of such restrictions or limitations.
All work exceeding the normal working hours is considered overtime. Some employees are exempted from statutory hour restrictions, including high-level white-collar employees (the quadri) and executives (the dirigenti), as well as certain kinds of sales staff such as commercial travellers (viaggiatori e piazzisti).
Section 5 of Legislative Decree No. 66 of 8 April 2003 provides that the use of overtime must be limited, and usually it is voluntary. The collective agreement typically provides the conditions for performing overtime work. If collective agreements do not cover when overtime can be required, it is allowed only with the consent of the employee, and for a maximum of 250 hours per year.
Overtime shall be paid with an extra remuneration as set out by the collective agreement. The collective agreement may set forth that, alternatively or in addition to such extra remuneration, the employees have compensatory rest time.
The right to overtime pay falls into the category of ‘unavailable rights’. Therefore, in an employment contract this cannot be waived by the employee. For waivers of unavailable rights, see question 46.
The minimum length of paid vacation is four weeks per year. The applicable national collective bargaining agreement may provide for a longer vacation.
The four-week period can be used for almost two consecutive weeks at the employee’s request, and the other two weeks (or the remaining higher period provided by the applicable national collective bargaining agreement) have to be used within the 18 months starting from the end of the accrued year.
Employees are also entitled to 11 days off as public holidays. Almost all national collective bargaining agreements provide for a supplementary holiday, the Patron Saint’s day.
The accrual of annual leave is connected to the effective work. In fact, annual leave accrues during the period provided for by the law while the employee carries out the working activity, but also during absences that the law or the CBA provide should be considered as a working period (eg, maternity leave).
According to Italian labour law, in case of sickness, an employee is entitled to keep his or her job position for a certain period of time that varies accordingly to each collective agreement and generally lasts almost 180 days in the space of one year (the periodo di comporto). This period is a suspension of the employee’s contractual obligation to carry out his or her working activity.
During this period, employees may be entitled to receive their full salary. A portion of the salary is paid by the INPS, and a national collective bargaining agreement may require the employer to pay the remaining portion. National collective bargaining agreements provide the length of such period and the rate of salary to be paid. They may also require that the protected period is included in calculations of length of service for seniority.
Maternity leave: workers are entitled to five months (usually two months before and three months after birth). During maternity employees have right to an indemnity from the INPS (80 per cent of salary); however, almost all CBAs provide the obligation for the employer to pay the remaining 20 per cent.
Paternity leave: employees are currently entitled to four days of compulsory paternity leave, plus one additional day of optional paternity leave to be taken in place of the mother during her maternity leave.
at certain income conditions that vary each year, during the first eight years from childbirth, for the periods of parental leave exceeding the first six months and up to 10 months.
There is no right to indemnity if the parental leave is taken when the child is aged between eight and 12 years old.
Marriage: any employee, except during the trial period, is entitled to special paid leave in case of marriage. The duration of the leave is 15 days. Almost all applicable national collective bargaining agreements provide for 15 days of paid vacation.
Disabled employees or leave for assistance to disabled relatives: disabled employees or relatives of a disabled person have the right to paid leave, which in general is three days per month.
The other main circumstances giving the right to leave of absence are the following: medical leave for specific reasons (eg, drug-addicted workers, blood donors); political offices; serious personal reasons; and study or training leave.
An employee’s service seniority may give the right to some benefits (eg, the right to additional holidays). However, most benefits (such as complementary insurance, pension plan, etc) are provided by the CBA for specific categories of employees (in particular, managers and top managers).
Part-time employees are entitled to receive the same treatment as is provided by the applicable CBA or company collective agreement for full-time employees that are at the same contractual level, as defined by the applicable CBA itself. Part-time employees also have priority rights when it comes to full-time vacancies at the employer (for the performance of the same duties or duties at the same level pursuant to the CBA) in circumstances where the employment relationship was originally full-time and then it changed to part-time.
Fixed-term employees are entitled to receive the same treatment as employees who are on open-ended or indefinite contracts of employment at the same contractual level under the applicable CBA or company collective agreement, as defined by the CBA itself. In addition, if a fixed-term employee has worked for an employer for more than six months (even if under different fixed-term contracts) he or she has the right to be given priority for a permanent position for 12 months after the end of the fixed-term contract if the employer is hiring employees to carry out the same work activities as the fixed-term employee, provided he or she has indicated his or her intention to benefit from such a right in writing within six months of the end of the fixed-term contract.
In the private sector, there is no general obligation to publish information on pay or other details about employees or the general workforce. However, some exceptions are provided for listed companies. In particular, the board of directors (or the supervisory board) of listed companies must publicly disclose an annual report on the remuneration of general managers and executives with strategic responsibilities.
In addition, the law provides for some obligations to inform the unions or staff representatives (eg, staff representative bodies are entitled to be informed by employers with more than 100 workers every two years about male/female equal treatments - Law Decree No. 198 of 11 April 2006, section 46). The CBA may provide similar obligations on salary treatments and other matters having an impact on the general workforce.
have a specific duration, which shall not exceed three years (five years for executives, ie, dirigenti).
In order to assess the validity of a non-competition covenant, it is necessary to ascertain whether the combination of its terms, extents and conditions prevents or not the employee from finding other employment or violates the employee’s right to preserve his or her professionalism.
There are no specific provisions on covenant not to solicit (customers, employees or suppliers) or deal (customers), thus the parties can freely agree their content. However, it is debatable whether the above statutory requirements would also apply to the non-soliciting covenant.
The employer shall not pay the salary but the compensation specifically agreed in the non-compete covenant. The law does not provide for a specific amount of the consideration, and case law requires that the compensation is ‘congruous’, having regard to restrictions imposed on the employee’s professionalism and his or her right to work. Therefore, the compensation has to be evaluated on a case-by-case basis, in the light of the other terms agreed (ie, duration, scope, geographical extent and the skills and experience of the employee).
According to section 2049 of the Italian Civil Code, the employer is liable for acts unlawfully committed by its employees. Pursuant to case law, the duties performed by the employee should have made possible the commission of the damage to the third party.
income over €75,000: 43 per cent.
In addition, the employer and the employee should pay social security contributions. The amount depends on the classification of the company and the employee’s level.
The contributions are entirely paid by the employer to the INPS. The employer withholds the percentage due by the employee from his or her salary.
inventions made outside the scope of the duties assigned to the employee but related directly to the business of the employer or made with use of data or means, of whatsoever nature, of the employer (‘occasional inventions’): the employer has an optional right to use the invention or purchase the patent and should recognise to the inventor a licence fee or a price for the sale of the invention, deducting any amount for the aid received by the employee from the employer.
With respect to trade secrets, there are specific rules set forth by Legislative Decree No. 30 of 10 February 2005.
the personnel who have control over it implement measures to restrict its access.
There are no specific rules dealing with confidential information. Confidential information is usually specified by the employer and the employee within the employment contract or within internal policy rules.
In addition, rules can be drawn from articles 1175 and 1375 of the Italian Civil Code regarding bona fide execution of the contract and article 2105 of the Italian Civil Code regarding the employment relationship and the prohibition to disclose the company’s information by the employee.
Data protection issues in Italy are regulated by Legislative Decree No. 196 of 30 June 2003, commonly known as the Italian Data Protection Code (DPC). This brings together all the various laws, codes and regulations relating to data protection that have been created since 1996.
Data protection legislation must apply jointly with the employment laws set out in the Workers’ Statute. According to section 4 of the Workers’ Statute, the instruments and equipment that are potentially able also to monitor employees are permitted only to the extent they are required for organisational, productive or safety reasons or for the safeguarding of company assets, and provided that their use is agreed with the works council or most representative trade unions or authorised by the Labour Office, depending on the specific case. The provisions specify that such rules do not apply (thus no agreement or authorisation is needed) to the instruments and equipment used by employees for performing the activity (eg, laptop or mobile phone) or to devices that are used by the employer to register employees’ access and attendance at the workplace. In addition, the data and the information collected through such instruments and equipment can be used for all purposes related to the employment relationship, provided that the employees have been adequately informed on how instruments can be used and how the controls can be carried out, in compliance with data protection legislation.
From a privacy perspective, the Italian Data Protection Authority (DPA) issued some provisions (‘Guidelines applying to the use of email and the internet in the employment contest’) requiring data processors to define internal policy for the use of internet, email and IT equipment and, in general, internal procedures for data protection purposes.
The employer should inform employees in advance and unambiguously about any processing operations that may concern them in connection with possible controls. In particular, employers are required to provide in the ‘Guidelines applying to the use of email and the internet in the employment contest’ information and instructions on the appropriate use of the IT devices supplied and relevant controls (eg, monitoring), if there are any. More specifically, employers must inform their employees on what type of tools are being used, as well as whether and to what extent controls are carried out.
Paragraph 1 of section 2112 of the Italian Civil Code states that in the event of ‘a transfer of an undertaking, the employment relationship continues with the transferee and the employee maintains all the rights deriving from the employment’. Therefore, by operation of law, all employees attached to the business (or part thereof) subject to the transfer automatically transfer to the transferee.
In addition, the transfer is not a valid reason for dismissal. Therefore, the transferor cannot dismiss the employees on the grounds of the transfer (ie, the dismissal will be considered null and void and the employment relationship will continue with the transferee). Any dismissal made in connection with the transfer will be considered null and void unless there is a productive and organisational reason justifying the dismissal that entails changes to the workforce (restructuring resulting in job losses). Similarly, the transfer does not prevent an employee from being dismissed for disciplinary reasons.
As far as individual dismissals are concerned, Italian labour law provides two different kinds of dismissal: dismissal for ‘just cause’ and dismissal for ‘justified reason’.
According to section 2119 of the Italian Civil Code, a permanent employment contract can be immediately terminated without giving any notice or payment in lieu of notice for gross misconduct committed by the employee (defined by Italian law as ‘just cause’). In particular, section 2119 provides that each of the contracting parties may withdraw without any notice if a cause occurs that does not allow the continuation of the employment relationship (even on a provisional basis).
‘objective’, ie, a reason concerning the production or the organisation of the working activity in the enterprise.
A dismissal for ‘subjective’ or ‘objective’ reasons does not give the employer the right to terminate the employment contract without notice.
Laws No. 604 of 15 July 1966 and No. 108 of 11 May 1990 exclude ‘justified reason’ for the dismissal of dirigenti. To protect executives against dismissals, almost all CBAs for executives require that their dismissals need to be ‘fair’. As a general rule, according to the Supreme Court’s decisions, an executive’s dismissal is considered fair only when it is not based on false, arbitrary, discriminatory or non-existent reasons.
Under Italian law the notice period - which is provided only in cases of dismissal with justified reason - varies depending on the CBA applied by the employer and on the seniority and level of the employee.
The employer can provide pay in lieu of notice.
The employer can dismiss an employee without notice or payment in lieu of notice in the event of ‘just cause’, meaning a cause that does not allow the continuation of the employment relationship (even on a provisional basis).
the pro-rata amount of the supplementary monthly salary (if any).
immediately following the receipt by the employee of the justification letter.
The employer must communicate in advance its intention to proceed with individual dismissal to the Labour Office of the employee’s workplace, copying the same employee and explaining the reasons for the termination. This procedure applies only to the dismissal of employees (not having the role of dirigenti) hired before 7 March 2015 and employed by companies having 61 or more employees in the whole Italian territory, or 16 or more employees in a single business unit or in more business units within the same municipality (Comune). Within seven days of the receipt of the above communication, the Labour Office summons the parties before the Conciliation Office for a meeting in which the parties will attempt to reach an agreement. The procedure will terminate by and not later than 20 days starting from the day in which the Labour Office sent the communication of summoning.
Should the parties not reach an agreement or, in any case, after seven days have elapsed without any summoning communication by the Labour Office, the employer can serve the dismissal.
For collective dismissal procedures, see question 42.
Employees are entitled to specific protection in case of null and void or unfair dismissal.
dismissal null and void according to other mandatory law provisions (eg, pregnancy, maternity leave, etc).
The above protection applies to all employees regardless of the level, the date of hiring and the size of the employer.
For other types of dismissal, the sanctions vary depending on the type of dismissal, the size of the employer (there is greater protection for employees in ‘large companies’, ie, employers having over 60 employees in the whole Italian territory or over 15 in a single business unit or in several business units within the same Comune), the date of hiring and his or her level.
pay the dismissed employee an indemnity ranging from 2.5 to six months’ gross salary.
It is up to the employer to choose between rehiring the employee and paying the indemnity.
The above sanctions apply only to employees hired before 7 March 2015. For employees hired after that date, the only sanction is the payment of an indemnity equal to one month’s salary per year of service, with a minimum of two and a maximum of six months’ salary.
Similarly, for employees in large companies the consequences also vary depending on the date of hiring.
(ii) the contested behaviour could have been sanctioned with a conservative measure according to the applicable collective bargaining agreement.
In this case, the employee has the right to be reinstated, and the employer has to pay him or her the unpaid salary for the period between the date of the dismissal and the date of the effective reinstatement with a maximum of 12 months of salary. The employee will also have the right to choose the 15 months’ salary indemnity in lieu of reinstatement.
Should the judge ascertain that the ‘justified subjective reason’ or the ‘just cause’ does not occur for different reasons than those set out at points (i) and (ii) above, the employee is entitled to a payment of an allowance ranging from a minimum of 12 months’ salary to a maximum of 24 months’ salary.
Employees have the right to be reinstated only in a specific case of disciplinary dismissal (ie, dismissal for ‘just cause’ and for ‘justified subjective reason’), when it is proved that the ‘material fact’ upon which the dismissal was based did not occur. The reinstatement should be implemented together with an indemnity equal to the salary from the date of dismissal until the reinstatement with a cap of 12 months’ salary. As above, the employee also has the right to choose the indemnity in lieu of reinstatement.
In all other cases, the employee will only be entitled to monetary compensation equivalent to two months’ salary per year of service (minimum four months’ salary, maximum 24 months’ salary).
The sanctions for unlawful individual dismissal vary depending on the date of hiring and the size of the employer.
Small companies would be ordered to rehire the employee or pay him or her an indemnity ranging from 2.5 to six months’ salary above mentioned (it is up to the employer to choose between rehiring the employee and paying the indemnity).
As far as large companies are concerned, the employee has the right to be reinstated in the event that the fact on which the termination was based is ‘manifestly groundless’ (in addition, an indemnity for the remuneration lost, with a 12-month cap, is due). In all other cases, the employee is entitled to a payment of an allowance ranging from a minimum of 12 months’ salary to a maximum of 24 months’ salary.
Employees in large companies do not have any right to be reinstated, being entitled only to increasing monetary compensation (two months’ salary per year of service, with a minimum of four and maximum of 24 months). Employees in small companies would be entitled to an indemnity equal to one month’s salary per year of service, with a minimum of two and a maximum of six months’ salary.
As a residual measure, in the event of non-compliance with procedural requirements required by the law for disciplinary dismissals and individual redundancy indicated above (see question 40), the employee would be entitled to a payment of an indemnity, which varies depending on the size of the employer and the date of hiring.
Small companies would be ordered to rehire the employee with a new employment contract or, alternatively, pay him or her an indemnity ranging from 2.5 to six months’ salary. In this regard, this sanction would be applicable only to employees hired before 7 March 2015, while to employees hired after that date the indemnity will be equal to 0.5 month’s salary for each year of service with a minimum of one and a maximum of six months’ salary.
is equivalent to one month’s salary for each year of service (subject to a minimum of two and a maximum of 12 months’ salary) for employees hired after 7 March 2015.
Should the judge ascertain that the dismissal is also unlawful for other reasons (and not only for the violation of formal requirements), the other sanctions indicated above will be applied depending on the type of dismissal.
Law No. 223 of 23 July 1991 provides that in the event that the employer does not comply with all the steps set forth in the procedure for collective dismissals, the employer shall pay the employee an indemnity ranging between a minimum of 12 months’ salary to a maximum of 24 months’ salary.
pay the employee an indemnity equal to the salary due between the date of the dismissal and the date of the effective reinstatement, with a maximum of 12 months of salary.
Employees shall be entitled only to the monetary compensation above mentioned (two months’ salary per year of service seniority, from a minimum of four to a maximum of 24 months’ salary), with the right to reinstatement limited to the dismissal being communicated orally.
Specifically, monetary compensation will also be the only remedy in the event that the employer does not comply with the criteria governing the selection of employees to be made redundant.
If the dismissal is judged to be unfair, an executive is entitled to a supplementary indemnity payment provided by the applicable national collective bargaining agreement, ranging from a minimum to a maximum number of months of salary.
Law No. 161 of 30 October 2014 has introduced specific sanctions for unlawful dismissal in cases of collective redundancy. In particular, in the event the dismissal of the executive is in breach of either the procedure or the selection criteria, the employer shall pay him or her an indemnity ranging from 12 to 24 months’ salary, ‘unless the national collective bargaining agreements provide different provisions on the amount of said indemnity’.
Employees hired on a fixed-term basis cannot be dismissed before the expiry of the term except for just cause. The employee is otherwise entitled to the payment of the salary until that date.
women: according to section 5, paragraph 2 of Law No. 223/1991, the employer must ensure that it does not make a disproportionate number of women redundant. In particular, ‘an enterprise cannot make redundant a percentage of women higher than the percentage of women employed in the job categories concerned’.
The procedure provided by the law lasts for a maximum of 75 days.
It is possible that a national CBA may provide a previous and additional consultation to be implemented before the one provided by the law.
The employer should notify staff representatives and the relevant (external) trade unions of the decision to proceed to collective dismissal. If there are no staff representatives, the notification has to be sent to the most representative trade unions of the sector on a national level. If there is no existing works council, there is no obligation on the company to organise elections for one.
The same notification also has to be sent to the competent Labour Office.
Dismissals may be served within a period of 120 days from the conclusion of the procedure unless the parties have agreed a longer term.
The collective dismissal procedure also applies to dirigenti (who were previously excluded from the application of the procedure).
If the company and the trade unions do not reach an agreement within the maximum length of the procedure (75 days), or if they reach an agreement during the procedure, the employer is allowed to proceed with the dismissals.
The selection of employees to be dismissed must follow the criteria provided by the agreement reached during the procedure or, in the event of a negative outcome of the procedure, the employer must follow the criteria provided for by the law (family conditions, length of service, technical, productive or organisational matters).
Generally, employees assert labour and employment claims on an individual basis. However, it may occur that a group of employees bring one single claim against the employer in order to ascertain the same right (eg, the right to payment of a bonus arising from the company’s collective agreement).
In addition, certain particular labour claims can be filed by ‘collective actors’ (eg, a trade union can bring a claim for anti-union behaviour; and the Counsellor for Equal Opportunities can bring a claim in the event of collective discrimination in the workplace).
Italian legislation allows employers to dismiss employees that have reached the retirement requirements, but there is no obligation to do so (unless for certain exceptions in the public sector).
The old age pension requirement in 2018 is 66 years and seven months for men and women, with a minimum of 20 years of contributions. However, for large companies the possibility to dismiss an employee that has decided (and agreed with the employer, according to case law) to continue to work despite the achievement of the old age pension requirement would be applicable only once the employee turns 70 years old (this age limit is subject to change owing to developments in life expectancy).
before an arbitration court specifically appointed on the parties’ accord.
In principle, arbitration is optional, so each party has the right to bring an ordinary action before the competent labour court.
The employee can lawfully waive statutory and contractual rights to potential employment claims. However, according to section 2113 of the Italian Civil Code, where the subject matter of waivers and settlements concern the individual’s employment rights arising from mandatory provisions of law (such as the right to challenge the termination) or collective agreements or arrangements concerning the employment relationship, such waivers will be invalid unless the agreement is signed before a competent body (trade union, labour council or labour court). If not signed before such bodies, the waivers and settlements shall be null and void and the employee can challenge them within six months from either the date of termination of employment or the date of the waiver or settlement if agreed post-termination of employment.
The employer does not have to offer the employee financial consideration in exchange for agreeing to enter into the agreement, or in order to obtain an effective waiver of claims or withdrawal from litigation that has commenced. However, this is very common in practice as an incentive to obtain the employee’s consent to the agreement.
It is worth noting that employees hired after 7 March 2015 benefit from a ‘quick settlement procedure’ introduced by the Legislative Decree No. 23/2015. In particular, the quick settlement agreement consists of an offer by the employer to the employee, made within 60 days from the date of the dismissal, to pay compensation equal to one month’s salary per year of service, with a minimum of two and a maximum of 18 months compensation (for small companies the indemnity is reduced to a half and the maximum is six months’ salary).
This indemnity is not subject to tax or social security contributions and will be immediately paid by the employer via a ‘cash cheque’. If the offer is accepted by the employee, all rights to object to his or her dismissal will be waived. In the same settlement agreement, the parties could also decide to waive all rights in relation to the employment relationship, but any amount granted for such waivers will be subject to ordinary taxation and social security contributions as provided for under Italian law.
Depending on the type of claim, an employee’s claim must be brought within a period of time that may vary from five to 10 years.
Specific rules apply in the event of termination: in this case the employee must challenge the dismissal in writing within 60 days of its communication and must then bring the claim to court within 180 days.
Recently, a new law (Law No. 179/2017) has entered into force and regulated whistleblowing obligations and protections of employees adopting the organisational model (set out by the Legislative Decree No. 231, 8 June 2001), namely, the model that should be adopted in order to be exempt from administrative or criminal liability (the model is tailored to the company in light of the specific risks arising from its activities, aimed at preventing the commission of criminal offences provided for under Legislative Decree No. 231/2001).
These include, for example, crimes against the public administration, computer crimes, crimes of fraud in trade, corporate crimes, crimes of insider trading and market manipulation, crimes of manslaughter and serious or very serious bodily injury, breaches of accident-prevention and occupational health and safety rules, receiving, laundering and using stolen money, goods or utilities, crimes in infringement of copyright and the crime of inducement not to make statements or to make false statements to a judicial authority, or environmental crimes.
provide specific sanctions concerning fraud or gross negligence against any individuals who breach the above-mentioned protection measures; this also applies to any whistleblower who reports false information.
The employee can report any retaliation or discrimination to the National Labour Inspectorate (this can also be carried out through a union representative), and any dismissal, change of duties or any other measure adopted by the employer towards the whistleblower for discriminatory or retaliatory reasons will be null and void. | 2019-04-24T20:29:33 | https://gettingthedealthrough.com/area/18/jurisdiction/15/labour-employment-italy/ |
The Essentials of Bowel Anastomosis (EBA) ® course is a valuable way of improving the technical competency of the surgical trainee.
It has been intended to introduce candidates to safe surgical practice within a controlled setting and it aims to teach, and to assess participant’s ability to use safe surgical techniques that are common to all forms of gastrointestinal surgery.
To participate in this course click on user login to complete the registration then go to find course to select course site and date. | 2019-04-20T08:45:59 | http://ebasurg.com/portal/detailed.aspx?id=89 |
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There is an interesting correlation reflecting the inverse health of the economy and the health of the intimate theatre community in Los Angeles. Mass media is all abuzz with news that property prices in Southern California are at the highest point in five years. Hurrah! Properties are for sale, and deals are being made for cash well above asking prices. Yet there is another part to the story that is not being told.
I don’t hold myself out to be a financial wizard, but it’s not hard to see that many property sellers are viewing this as a great opportunity to cash out. There are investment groups out there with oodles of money willing to bid anyone up to gain control of neighborhoods, and in the process they become the new leaders in the “carve out my own empire” movement.
How is this at all about theatre? Well, theatres are the temples of dreams. The dozens of cramped and under equipped facilities that artist carve into their dream factories, supported and paid for by those willing to put up shows for little more than the sweat they were willing to invest to produce a show, or a season – these are the dream temples.
Theatre artists, from producers to ushers, have given not only of themselves, but have paid rent and upgraded properties in their efforts to bring theatre to their communities. Now amidst the hurly burly and woohoos because properties are selling, well established theatre’s are being put in jeopardy. Companies that have long settled established homes are being forced out. Theatre companies that have struggled year in and year out to not only meet the wants of its audience and, the needs of their artists, but also the demands of their landlords, are suddenly finding themselves put into a situation where staying in their facilities is no longer tenable.
The very existence of some of these theatres has been the saving grace for some of these landlords. Not only were are there theatre companies willing to pay to use their under appointed facilities, but the artists added to the value of the facility and the neighborhoods where they set up shop.
And what of the neighborhoods? Take North Hollywood, which in days gone by was known as the seedy underbelly of the San Fernando Valley. It has come to be the home to twenty-two live theatre spaces. In the process, restaurants found new patrons, shops developed new customers and it became a safe place to live and work, visitors come from the entire metropolitan area to take advantage of the opportunities.
This community treasure opportunity is repeated in many places: Hollywood, West Hollywood, Downtown, Venice, Santa Monica, Atwater, San Pedro, Long Beach . . . where there are people, theatres crop up.
Now, the numbers are begging to be affected. Celebration Theatre is looking for a new home, Rouge Machine is looking, Couerage Theatre, Open Fist…. the list goes on. This month, one of the long standing theatres in North Hollywood, the Avery Schrieber, is being converted into a bistro. Companies that used to survive by putting up eight to ten shows a year, are now finding greater portions of their monies spent on rent rather than producing. All in the hope of keeping a space that in actually may be being sold from under them.
So, while figuratively speaking, “Rome (the economy) was burning,” for the last six years, intimate theatre forged forward and kept their promises. In the process, they helped sustain the landlords. And all the while, we the audience keep looking for the deal tickets, the free tickets, the cheap tickets.
Now, while we may not all be feeling the economic recovery, theatre companies that we have come to rely on for quality work are being forced out of their facilities. Squeezed by property owners to pay outrageous rents, and squeezed by the audiences to offer cheap or free entertainment.
I remember as a young boy reading about Christ casting the moneylenders out of the temple. Merchants had taken the opportunity of spiritual enrichment and used it as a source for their own personal enrichment. I think I’m finally beginning to understand the outrage.
I’m not suggesting that property owners forego their enrichment. Where would we be without that great American tradition of self-enrichment? I am a capitalist, but I also see that we have a responsibility to sustain and enrich our culture. As a society, we are bound to find ways to assure that we have, for lack of better expression, constant spiritual growth.
There is no more effective symbol of the greatness of mankind than that of the creative spirit. Art in all its various forms elevates us. When we create, we emulate the very nature of creation. Our godhead shines, and never is it more apparent then upon a stage. Multiple artists focusing their energies to create a once-in-a-lifetime moment. When we see that event, we are the only ones that will ever see that moment. It exists only to shine for that second, and then we move on.
I plead that as we sit and look for the next show we want to see, we realize that we have a responsibility to support this artistic effort. If you have the wherewithal, pay the full price for the ticket. Saving $6 -$15 per person can be a consideration for you, but multiply that by a hundred tickets a night, then by twelve or more performances on the run of the show, and you begin to see how profound an effect you have on the well being of the theatre.
We cannot force the property owners to give the theatres a break. However, we can ask our representative to offer them tax incentives, we can plead throughout our communities for stronger support, and we can be willing to pay a reasonable amount for our tickets. And, if you’re really feeling the glow of economic recovery, dig a little deeper and offer a donation. You’ll move from being audience, to patron. And let’s face it art needs patrons. | 2019-04-25T20:14:30 | https://footlights.click/2013/04/05/defining-the-temples/ |
The Husqvarna Technical series is a range of clothing that provides high protection all day every day for professional users, while still allowing you to carry out work comfortably. It’s designed to be light, strong, flexible and ideal for use in the forest.
Task-optimised design meets modern styling, while tough, light stretch fabrics, reinforced panels and pre-bent knees and elbows offer high resistance, durability and performance. | 2019-04-25T19:43:58 | https://www.agripartsonline.co.uk/125-husqvarna-ppe-technical |
Joel Lightner, M.D. - Radiology of Huntsville, P.C.
Leon W. Bell, III, M.D.
John R. Collins, Jr., M.D.
Alex W. Johnson, M.D., F.A.C.R.
D. John Wester, Jr., M.D.
Ronald B. Workman, Jr., M.D.
Dr. Joel Lightner Jr. received his undergraduate degree at University of the South and Medical degree from Mercer University. He then attended Tulane School of Medicine for an internship in Medicine before traveling north to the University of Vermont for Diagnostic Radiology. As a second generation Radiologist, Dr. Lightner considered becoming a generalist but was offered the rare opportunity to complete a fellowship with Gilda Cardenosa, M.D., renowned Radiologist in the field of breast imaging. Immediately afterward, he spent four years practicing and teaching at the breast imaging department at University of South Alabama as the Director of Breast Imaging before joining Radiology of Huntsville. | 2019-04-19T05:03:22 | https://www.radiologyofhuntsville.com/physicians/joel-lightner-m.d |
The CSS3 box-sizing property can be incredibly useful when you want flexible widths on elements that also have padding and/or borders. And browser support is rather good.
How to make Mac OS X display the current week number.
My current thinking on document outlines in HTML5 and how and when to use the new sectioning elements, all with HTML4 compatibility in mind.
Keyboard accessibility really is not that hard to get right, but many, many web developers do not seem to think about it. Here are some simple guidelines that may help.
The contents of the title attribute in HTML is difficult or impossible to access in current browser implementations if you do not use a mouse.
How to configure Apache on Mac OS X to use virtual hosts with local host names and parse .html files for PHP and SSI. | 2019-04-19T16:24:29 | https://www.456bereastreet.com/archive/201104/ |
A countertop dishwasher, as the name indicates is a product that is used to wash utensils at the top of the counter. just like many other product there are so many companies that are producing this particular product, but all these products are not as good as they should be. So if you in need of best countertop dishwasher, then this you are at the right point because here you will get a great collection of top ten best products and all these products are outstanding in performance and quality.
The use of these products will make you very happy and you will have a wonderful experience. Here you will also get a buying guide that will help you in selecting the best product.
This countertop dishwasher is one of the best in the list. This electronic dishwasher comes with a 6-place setting kitchen. The product is very easy to connect to ant countertop and the water consumption capacity of the product is also least. The rinse agent dispenser and automatic detergent are two prominent features of this product.
The stainless tell interior of this product has increased its performance. The six wash cycles of this product are speed, glass, soak, high, light, and heavy. The LED display of this product is very helpful in determine the performance of this product.
This is another highly versatile and excellent product that we have collected for you. The 6 plate setting capacity of this product helps in the easy adjustment. By using this product, you can adjust the settings up to 10. The electronic LED display is an eye-catching feature of this product that you can enjoy.
The product has a wide plenty of space for adjustment. The seven wash cycle is a worthy feature of the product. The product is very fast and simple to adjust and operate. The leasing is easy. Theremovable utensils can be removed easily.
This is another unique countertop dishwasher that you can enjoy. The interior of this product is durable and attractive. The product can afford up to 8 hours of delay. There are 6 wash cycles in it. The standard place setting is 6. The quick and simple connection has made it an attractive product. The dich rack and basket rack are made of plastic.
The product offers a rinse- add capacity. The controls of the product are friendly for the user. The rinse agent dispenser is also available. The design is compact and versatile. The water consumption capacity is up to 3.8 gallons.
This product also consists of the 6 place counter setting. The diameter of this product is ideal to use in all types of kitchens. The interior and exterior both are made of stainless steel. The product offers a water consumption of up to 3.5 gallons. The product is tall and its countertop is easy to adjust. The portable dishwasher helps in the adjustment and performance.
The faucet adapter in this product is wonderful and worthy. The dishes are easy to clean. The product is very easy to operate. The interior water heat capacity of this product is also amazing. The built-in-rinse agent dispenser of the product is outstanding in performance.
This product is also called as the compact space saving counter-top dishwasher. The quick connect system has made it use-able for any kitchen. The silverware basket along with a stainless steel interior and 6 place setting are attractive features of this product. The water consumption capacity is 3.1 gallons. There are 6 wash cycles int his product.
The delay start option of the product is from 3 to 8 hours. The 6 settings of the product can be easily monitored and adjusted at the electronic LED screen. The product is simple and quick in instillation. The auto detergent and rinse-dispenser are worthy. The stainless steel material has increased its performance.
This 680 watts countertop dishwasher comes with 6 place settings. The stainless steel material comes with a quick to adjust system. The floating switch and the anti-flood device protect it from damage and destruction. The detergent and rinse-add dispenser are also attached to the product. The outlet hose of this product is wonderful in performance.
This is a large countertopr dishwasher that comes with a roomy space. The knob of the program is versatile and unique. The anti-flood mechanism of this product helps in the adjustment of the utensils. A quick to set seat is also attached. The plugs and outlets of this product has made it an appeasing product that is very easy to adjust.
This product comes with a universal faucet adapter. The indicators lines on this product are worthy and appealing. This is another unique countertop dishwasher that you can enjoy. The interior of this product is durable and attractive. The product can afford up to 8 hours of delay. There are 6 wash cycles in it.
The standard place setting is 6. The quick and simple connection has made it an attractive product. The dish rack abd basket rack are made of plastic. The product offers a rinse- add capacity. The controls of the product are friendly for the user. The rinse agent dispenser is also avaialable. The design is compact and versatile. The water consumption capacity is up to 3.8 gallons.
This portable countertop dishwasher comes with an elegant style and design. This countertop dishwasher is one of the best in the list. This electronic dishwasher come with a 6-place setting kitchen.The product is very easy to connect to ant countertop and the water consumption capacity of the product is also least.
The rinse agent dispenser and automatic detergent are two prominent features of this product. The stainless tell interior of this product has increased its performance. The six wash cycles of this product are speed, glass, soak, high, light, and heavy. The LED display of this product is very helpful in determine the performance of this product.
If you are looking for an easy to use countertop dishwasher, then this product is for you. The detergent and the rinse dispenser of this product are wonderful in performance. The product can afford a delay of 4 to 8 hours. The 6 plate setting capacity of this product helps in the easy adjustment. By using this product, you can adjust the settings up to 10. The electronic LED display is an eye-catching feature of this product that you can enjoy.
This small sized home appliance is very easy to manage and adjust. The product has a wide plenty of space for adjustment. The seven wash cycle is a worthy feature of the product. The product is very fast and simple to adjust and operate. The leasing is easy. The removable utensils can be removed easily.
Material: This is the most important thing that you should keep in the mind while buying a countertop . dishwasher. The whole performance of the products depends upon the construction material. Therefore the material must be of good quality.
Wash cycles: This is another thing that you should consider while buying a countertop dishwasher. The was cycles help in the quality cleansing of the utensils. So make sure that product has six or seven wash cycles.
LED display: An LED display helps you in watching the performance of the product. The product that you are buying must have an LED display so that a good buying decision can be made.
Price: The price off the product must be affordable and according to your budget so that you can buy a good product in affordable price. The price of the product must be fordable for everyone.
All these countertop dishwashers are best for the year 2019. These products are made of good quality materials and the performance of all these products is also astonishing. You will enjoy all these products after having a singular experience of this product. The wash cycles, speed, the counter space, and the delay hours of this product are just awesome. I hope the use of these products will make you happy and you will have a wonderful experience. | 2019-04-18T18:27:58 | https://www.tentopproduct.com/best-countertop-dishwashers/ |
Preparation: Give the trophy to the unsuspecting Leader telling him that you'll ask him to present it to the camper after this skit.
Have BILLY the brave camper sitting in the audience.
Have all the other campers offstage.
Script: MC: Campers, Parents, and Guests - welcome. We have with us today a very special camper. Billy, please come up here. This young man has proven his bravery through trials and challenges most of us would never dream of let alone live through.
MC: As you can see, nothing scares this bravest of campers, not even the most hideous monsters of the world. And, to recognize Billy's bravery, our leader, Mr. ______, will now present him with a small trophy. Good job, Billy! | 2019-04-24T14:28:13 | http://campingdude.com/content/skit/bravest_xperson_in_the_world-138.asp |
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...this year certainly is! I feel as though I'm doing a swift jog to keep up. Sometimes you just have to take a minute to slow down and smell the flowers, so here I am with a Flowery First Of The Month post.
It all started on a summers day at Flower School. I was learning about floral foam, you know the green stuff that you stick flowers into. For some reason watermelon popped into my brain, no -not because I was hungry, but because it has a similar consistency to the foam and it holds water (juice). The fact that it is a wonderful pink colour that is complimentary to both bright or pastel flower colours was an added bonus.
So before I was lead astray by other ideas, I raced off to the fruit shop and bought some watermelon. I took it home and gleefully like a crazy flower lady, shoved flower stems into it. My idea worked a treat!!
I've used different flowers over the years. Gerberas add happy colour, Birds of Paradise and Orchids are great for creating a tropical display, even green leaves used artfully look fresh and fun. Today I started with some electric pink zinnias from my garden.
The longevity of the flowers differs according to the different varieties, and other factors such as the ripeness of the watermelon, and heat of the room. I find they usually last about a day though I once had some gerberas last 4 days. It's more a style of arranging that's best suited for a party, a function or an afternoon of creative fun.
You can use the watermelon as little wedges. Picture a row of watermelon triangles on banana leaves running down the center of a long table, with abundant orchids arranged proudly in different colours.
to feature a single beautiful bloom.
For something different I tried it with a kiwi fruit. The result made me laugh, they look so cute and comical.
Wishing everyone a fun, frivolous and fruity March.
Oh Rachael, you make me laugh! What a fun idea! These images will have smiling all day!
What a hoot! Who would have thought fruit and flowers but it's delightful. You are so creative.
I started smiling when I read your post, a clever idea as the flowers would get moisture from the fruit. I wonder if it would work with a whole watermelon as well, of course you would have to poke holes in it to get through the skin.
Cherry Zinnias are one of my favorite summertime flowers. :) Who would have guessed they would look so cute in a watermelon!
Haha, I love this. I hope I can remember this for our 4th July. I am picturing daisies and little flags stuck in Watermelon. Thanks for such a cute idea!
Such fun! I love them all. I MUST try to do something similar. Hope you got to eat a slice of watermelon too.
A great way to think outside the box! Or foam, in this case. The kiwi makes such a whimsical statement too!
Just imagine white and blue daisies in a slice of watermelon! The though t is delicious! Brilliant idea!!
You're enjoying this aren't you. Nothing like watermelon on a hot day. They look great, so cheerful.
You do have such a creative mind Rachael, but I'd be wanting to eat the fruit instead of poking flowers into it - although with the right flowers I guess you could do both.
HeHe... so fun dear Rachael!
To that I would add and so delish!
HA!!! who wouldn't smile seeing this as a centerpiece! that's just FUN!!!
You are clever & creative, Crazy Flower Lady!
Rachael, when I first saw the link to your post I thought you had stitched the zinnia in wool! But now is see it as an actual photograph of the Zinnia.
What a creative idea for displaying the flowers.
What a great idea! The kiwi fruit do look so funny.
Your post today made me want flowers, especially those hot pink zinnias and watermelon. What an awesome idea!
I do like this fun idea. I will never see watermelon in the same way. I do think the arrangements look great. Thank you for such a lovely idea.
I love it! But now my mouth is watering for watermelon - it would never last long enough around here to get flowers!
So pretty. It's going to be a while before juicy fruit are around here but we are getting flowers!
That is so beautifully quirky. I love it!!
Rachael, sorry this comment is not in relation to this post but I can't seem to email you. Wondering where to find a photo of your finished Sis Boom hexagon quilt? Thanks!
Oh my goodness! How funny! I seem to remember putting cut flowers into colored water and changing the color of the flower petals. The fruit is a fun idea and eco friendly!
What a great idea brilliant.
What a fun, natural way to display flowers. Personally I love the kiwi holders best!
guess you make lots of folks laugh...good...very good...laughing is a wonderful idea...unfortunately, you make us hungry too...like the watermelon.. Watermelon festival is not until July in Charlotte..so I guess I will have to wait.
Enjoyed your post, Rachel. LOL - but I'd eat the fruit before I got flowers in there. Those are two of my favorite fruits.
You're hysterical! This comes under the heading "Who thinks this stuff up" LOL. What an adorable idea! The possibilities are endless!
this. The best use for watermelon and have you tried other melons, like orange and yellow ones? This is VERY FUN. Thanks.
How cool! At least watermelon has one useful purpose! I loathe watermelon. I was sick once when I was a kid not long after I had eaten watermelon and yeah I know it wasn't the watermelon that was the problem but it has put me off it for life. I love your ingenuity.
That is one of the cutest, most unique things I've seen in a while!
what a great and creative idea! fruit and flowers, a natural combination!
Such a cool post RAchael...love it!
So, SO fun! Thank you for the bright opening to my Monday morning. | 2019-04-22T14:23:55 | https://bluemountaindaisy.blogspot.com/2015/03/marching-right-along_1.html |
Best sherwin williams neutral paint colors is one images from 20 popular neutral paint colors is mix of brilliant creativity of Djenne Homes photos gallery. This image has dimension 595x1024 Pixel and File Size 101 KB, you can click the image above to see the large or full size photo. Previous photo in the gallery is best neutral paint colors benjamin moore creative. For next photo in the gallery is most popular neutral wall paint colors. You are viewing image #17 of 20, you can see the complete gallery at the bottom below. | 2019-04-19T17:20:15 | https://djenneinitiative.org/20-popular-neutral-paint-colors-is-mix-of-brilliant-creativity/best-sherwin-williams-neutral-paint-colors/ |
Couldn't ask for a better rental experience. Kai is top notch - he knows his stuff and took excellent care of the gear. Happy to rent to anytime.
Quick, easy rental! Was a pleasure dealing with Kai.
Always great to rent to Kai.
Excellent renter, handle the equipment very good as always.
Treats gear like his own. Highly recommended!
Kai's an excellent renter. Rent with confidence!
Great Renter. Thank you for using us and hope to see you again soon.
Very attentive and communicative. Thanks!
Kai was on time and handled everything perfectly.
Solid Communication. No Issues. Would rent to again!
Everything worked great with Kai, the equipment came back in great condition, will definitely do business with him again.
Join KitSplit to see Kai M's full profile—it's free! | 2019-04-22T12:02:50 | https://kitsplit.com/profile/kaimie |
With a strong emphasis on designing products that are functionally innovative BIB design has often been involved in projects with a mechanical bias. From designing one off test and assembly machines to high value production units for specific tasks.
An energy efficient ECM designed from the ground up, complete with pumps, plumbing, discharge tanks, three axis head, and all structural framework and panelling.
A test facility to check the accuracy of moulded tail lights prior to assembly.
A test facility to check wiring looms and bulbs prior to assembly.
A one off assembly press for the bonding of luxury glove box units for Bentley.
BIB design has a reputation for creating innovative products developed from concept through to production. Traditionally that philosophy has precluded some consumer orientated product areas where the emphasis might be on re-styling or re-branding.
Every so often a project comes in that has obvious consumer potential and yet open for innovation, either in it's function, use of materials or deployment of technology.
Ecomold produced high quality mouldings for the automotive industry and wished to transfer a knowledge of using recycled plastics, in-mould labelling and twin shot moulding into a range of retail orientated goods. The range developed allowed for the introduction of such technology at various price points for the intended market.
with a number of innovative features.
Sibovar proposed an innovative cook pot with integral, high efficiency elements specifically to cater for a growing market in Russia. The brief required the technology to be successfully implemented into a range of products that would be used in market research to establish a visual preference resulting in the successful development of prototypes.
Medical products - both for diagnosis and for life preservation present a number of fascinating challenges for the designer. Innovation, collaboration, research, understanding user needs and fears and stringent quality checks.
BIB design has a long history in working with medical clients and understanding their needs.
Concepts exploring the analysis of blood and urine samples to control medication and alert users and doctors to impending problems. Detailed design exploring the mechanisms involved in getting successful samples, guiding the user through interactive screens and presenting a user friendly design that encourages use, breeds familiarity and instils confidence.
Concept development to assess the individual fixations of the eyes when reading text. Used to assess the problems associated with Dyslexia leading to potential treatment through Omnireads software and hardware solutions.
Concepts, detailed development and prototyping of emergency oxygen generators. Exploring mechanisms, thermal management, ignition systems, material properties and user options. BIB design has a long standing commitment to assisting Molecular Products in their range of Oxygen generators.
BIB design has assisted Molecular in the development of a large range of Carbon dioxide absorbers, both as stand alone units, as modules for anaesthetic machines and as replacement canisters for diving re-breathers. Incorporating volume efficient designs with predictable airflow, thermal management, plenum chambers, moisture traps and filter systems.
BIB design has worked on many office related projects, telecommunications, computers, stationary, filing cabinets and complete office furniture systems. Each project provides a new challenge to bring something new to the scene.
Portable office for Hot desking.
Designed for travel, home and office, providing safety and security for laptops and accessories. The concept developed for Paragon Office Furniture explored the concept of Hot desking to supplement their furniture range and enter new markets.
Whilst not in the mainstream of work carried out by BIB design a few projects have been developed specifically to cater for a retail presence. Point of Sale packaging, graphics and consumer orientated concepts to help clients to break into new markets.
A brief to find a marketable product for a client with a production facility that moulded brush heads. The TRIP shaving system was conceived, developed and marketed to the travel market via high street health and beauty stores. BIB design created the concept and worked with the client through prototypes and liaising with suppliers and retailers to ensure a successful launch into a new market.
Designed to mimic the styling of bass heavy speakers to suit the target audience.
BIB design has worked in the travel and sporting goods market with various projects over the years. The market is often lead by innovation and the desire to create something new for a growing audience.
Madison required preproduction images for a press launch of their upcoming range of mountain bikes. Graphic layouts and CAD were supplied to BIB design in order that marketing and exhibition material could be generated using high quality renders for banners and literature.
Communicating the identity of a company is far more than just a logo. Along with various designs in 2D for company logos, product icons, web site buttons and packaging, BIB design also creates products that reflect the company message.
Developed for a Mac software retail site.
Originally developed for a branding consultant, employing elements of a new logo and colour schemes within it's design, the robot company mascot was designed by BIB design to characterize the forward thinking, friendly, intelligent and helpful aims of their client.
BIB design has created videos, banners and publicity for exhibitions, designed layouts and pedestals and explored the possibility of virtual exhibitions for promotional purposes.
CAD renderings, illustrations and composite images used for brochures and general print publications.
Used by clients for exhibition screens, you tube and social media to promote and educate.
CAD renderings, 2D illustrations and 3D data generated and supplied for an on-line retailer.
A number of individual clients have employed BIB design to capture the beauty of their products.
BIB design also creates HDRI photographs to use in it's CAD renderings for accurate lighting and realism.
Constantly striving to explore new avenues within industrial design and related design philosophies BIB design has a policy of self initiated projects. These projects aim to create new directions and inspire alternative ways of thinking about the design of products with influences from many other disciplines.
Establishing an identity through the products designed and specified throughout it's airports has been an important part of BAA's corporate message linking all of it's various lounges, retail sectors, walkways and check-in areas.
A complete reassessment of the established design developed as part of a new Way-finding standard. The new signs employed diffusers and standard films in an easy to assemble modular design that was slimmer, more legible, easier to maintain and specify and introduced energy savings of up to 60% per unit.
The development of the Signbox lead to the implementation of a common language developed for all other signs, information points, leaflet dispensers, litter bins, clocks, bumpers, barriers, handrails and other items. Materials, finishes, sight lines and and an aesthetic theme were all incorporated. Liaison with Terminal managers, installers, manufacturers and executive board members was crucial to the success of the project. | 2019-04-19T09:18:25 | http://bibdesign.com/projects.html |
Muzaffar Wani , the father of Slain Hizbul Mujahideen Commander Burhan Wani, whose encounter death triggered the continuing cycle of violence in Kashmir, tells TOI that his son’s dream was to join the Indian Army when he was 10 and also play cricket like Parvez Rasool – one day hopefully for India. The government school principal also rules out Pakistan’s role in Uri, Pathankot, and Pampore attacks and insists that as a teacher, he tells his students the importance of taking up “good careers” like Kashmir Administrative Service and the IAS.
Almost two months since Burhan Wani’s death, protests in Kashmir haven’t receded. Who’s responsible?
There’s no call by the Hurriyat Conference for any shutdown. We didn’t realise that these shutdowns would turn violent. We’ve lost so much in the last two months. We want some resolution. It depends on the people, how they want to look at the assurances from India or the J&K government. When my own two sons got killed, others too lost their family members.
After your son’s death, do you think Kashmiri youth should pick up guns and fight against security forces?
Of course not. The better way is a dialogue between India and Pakistan. So that there’s peace in Pakistan and also in India. All Indians are our brothers and all Pakistanis are our brothers. We Kashmiris love every Pakistani and we love every Indian.
Eighteen Indian soldiers lost their lives in Uri. Evidence points to Pakistan’s role. How do you look at it?
How can it be Pakistan? Whoever entered Kashmir after becoming a militant is a Kashmiri. Even a Muslim from Hindustan can come. It could even be an attack by Kashmiri militants.
But Pathankot probe showed there were phone calls by terrorists to their families’ handlers in Pakistan. Banned terror outfit Jaish-e-Mohammad released audio mocking Indian agencies.
It’s necessary to solve the Kashmir problem. Else, these attacks may happen. But we don’t know where these militants are coming from or infiltrating as the borders are sealed by the Indian forces. What is the Indian Army doing? How did the militants reach from the border to Pampore? If there is evidence (against Jaish) then investigations should be done.
How did you learn about Burhan leaving the family? What was the family’s reaction?
On October 5, 2010, Burhan left home. He told his mother he was going to meet some friends but didn’t return that evening. Then we came to know that he had joined the militants. For two months before this encounter, I tried my best to convince him. His year of birth was 1994. I told him that he was born during the peak of instability and that it was obvious that he felt the pain. When he was 10, he told an Indian Army officer that he wanted to join the Army. He said this when a raid was being conducted to search militants in our village. Burhan had a strong liking for camouflage outfits. One of his videos shows he loved cricket. He would have loved to play for India, not Pakistan.
How difficult has been Burhan’s loss to bear?
It was very difficult but we learnt to bear it. In the last five years, I met him two or three times for just around two or three minutes. The last time was two-and-half years ago. He was always on his own. I am in a government job for my family. He was working for entire J&K.
Muzaffar Wani, father of slain Hizbul Mujahideen commander Burhan Wani.
How did your other children react to their brother’s militancy?
Before Burhan my son Khalid, who is four years elder to him, was killed in April 2015 by the security forces when he’d gone for a picnic. He was tortured to death. Police believed he’d gone to meet Burhan. There was no blood on Khalid’s body. He was with this three friends, who were first arrested and later released.
Pakistan PM Nawaz Sharif invoked Burhan at his UN speech.
When Bhagat Singh was fighting against the British, they called him a terrorist, but Indians maintained he was a freedom fighter. When the problem of Kashmir will be solved, India will realise Wani was a freedom fighter. I liked everything that Nawaz Sharif said. He said Burhan’s killing had brought a new light in this movement of freedom.
But Burhan in his videos instigated youths to join the war against India?
His aim was not to kill pro-Indians. He used to say those who are anti-Hizbul and police informers, will be killed. But although he was commander for two years he did not kill anybody. He was only issuing warnings. He wept when eight CRPF men had died.
Your meeting with spiritual leader Sri Sri Ravishankar was much talked about. How did it happen?
Nobody fixed that meeting. I had to visit a hospital. I thought why not stay at the ashram. I had seen Sri Sri on TV years ago. I had learnt that Dr Zakir Naik had met him. So why couldn’t I? We talked about Kashmir and he asked me about the solution. I told him that Indian leadership must talk to Pakistan. He asked me about how Burhan left us. He said it was Allah’s decree.
Sri Sri Ravi Shankar and Muzaffar Wani. Sri Sri Ravi Shankar and Muzaffar Wani, father of slain Hizbul Mujahideen commander Burhan.
How do you look at PM Narendra Modi’s invoking Vajpayee’s call of Insaniyat, Kashmiriyat, and Jamhooriyat?
He is wazir-e-Azam of Hindustan. More than 100 people have been killed in Kashmir in the last two months. He hasn’t shown any grief. He only expressed grief over the killing of soldiers.
Do you fear that your third son may pick up a gun?
I am certain Naveed will not do so. He has seen his brother Burhan and has desired to study. I would want my daughter Irm Jahan, who is in college, to become a teacher.
Are you inclined to join Hurriyat Conference or any political outfit?
I have six years of service left. I don’t think I want to join a political party.
How has Burhan’s death affected your career?
I am proud to have produced many Kashmir Administrative Service and Kashmir Police Service officers. I like to give good education to kids at school where I work as an administrator and tell them they must take up excellent careers. I don’t want other parents to allege that just because my son became a militant, I want their kids to become one. I want young kids to work hard, get educated and become good. | 2019-04-22T22:39:35 | http://zittara.com/2016/09/26/burhan-wanis-father-says-his-sons-dream-was-to-join-the-indian-army-as-a-kid-2/ |
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Your privacy is important to us. And so is our interest in seeing our products in real life on social media. As you have posted the picture on Instagram, we deem it legitimate for us to use your picture in our channels as well, in line with these terms and conditions. However, you and everyone that can be identified in your picture always have the right to decide if you want to be a part of our content or not, and Semper will remove a picture at once when a person that can be identified in that picture so requests. | 2019-04-20T00:54:16 | https://goodngo.se/yesgoodngo |
Gary Spencer cruises into Long Island in style to chat to the unmistakable Sir Ivan, a billionaire with a twist, whose dedication to doing good for the world is both charming and inspiring, but most of all, extremely entertaining.
set out to meet the ever charismatic, philanthropic billionaire and of course EDM billboard star, ‘Sir Ivan’, otherwise known as ‘Peaceman’. I have caught glimpses of the Peacemobile, and as much as I would love to jump out of it at my favorite NYC restaurant or nightclub, I was dreading the art limo wrapped in multi-colour hippy icons pulling up for me in this tiny enclave of Long Island known as Bridgehampton.
I too have an ego, but also a British heritage, which means a little bit less is more, so it was much to my relief when a suitably finished British racing green Jaguar soft top pulled in to the parking lot.
Ivan Wilzing was born the son of Siggi and Naomi in Clifton, New Jersey, in the mid 1950s. Miraculously, his father, Siggi B. Wilzig, managed to survive the horrors of Auschwitz in wartime Germany, and move to the USA, where he eventually took over two traditionally anti-Semitic businesses: one, an oil company; and the other, a commercial bank, both of which he grew into major successes.
Today, Ivan Wilzig is known as ‘Sir Ivan’, and he lives in a castle, which is set on five stunning acres in the Water Mill countryside. The Castle took 18 months to plan, build, and decorate, and was mainly orchestrated with Sir Ivan’s brother, Alan, who worked on the drawings with the architect. It boasts an outdoor infinity pool with underwater speakers, gym, tennis, volleyball and basketball courts, nightclub, movie theatre, and all sorts of secret dens and dummy walls that lead to even more adventures. In fact, it’s everything you would expect from a commercial banking billionaire’s home, except that Sir Ivan stopped banking a long time ago, and became a pop star on the dance charts!
Sir Ivan is much more casually dressed than I had expected as he calls out and strolls over to shake my hand. He’s wearing black shorts and shirt, and has the demeanor and tan of an ultra successful man that lives in the Hamptons, or owns a castle, even. He explains the ‘Sir’ title came about when he and his brother built the castle, and what started out as a family joke ended up sticking as his stage name. Peaceman became his nickname because once he shed his banker suits, he started wearing capes with a large Swarovski peace sign on the back.
By remaking and covering various anti-war and peace songs from the '60s and '70s, Sir Ivan has managed to return some very impressive dance chart positions, which has subsequently grown his celebrity persona to fuel various charitable foundations like his own foundation, The Peaceman Foundation, that seeks to benefit the victims of hatred and violence, Post Traumatic Stress Disorder victims, and the LGBT community. Sir Ivan would later go on to tell me that the LGBT teenage community has a four to five times suicide rate compared to the straight teenage community.
His first recording success was a cover of John Lennon’s Imagine, the first time any artist had covered a Beatles track and managed to turn it into a dance anthem. It reached number 31 in 2001, and spent nine weeks in the Billboard Chart. His biggest hit to date is Hare Krishna (2011) that went Top 10 on the dance chart, and continued charting for a whopping 13 more weeks. Two more songs he recorded went Top 10 in Music Week in the UK: Live For Today, and La La Land. His 2015 release, Kiss All The Bullies Goodbye, also spent many weeks on the Billboard Chart. All very respectable numbers for a man who spent much of his life on corporate Wall Street, and is now in his mid 50s.
“There’s no question that my love of dance music came from my disco days; that high energy makes people wanna dance. Sure, Studio 54 was the coolest club to get into at the time, but there was an even cooler club that gay friends of mine would go to called The Saint, where people danced under a real planetarium. I went one time just to see what they were talking about, and it was really out of this world,” he explains.
What’s even more impressive is that through his enthusiasm and financial clout, Sir Ivan probably uses more producers and engineers than any of the major labels, and can even attract world famous talents to collaborate with, such as DJ and producer, Paul Oakenfold, and singer, Taylor Dayne, to work on his projects, such as Kiss All The Bullies Goodbye.
2015 was a very busy year for Sir Ivan; he made a one-hour documentary titled Sir Ivan - I Am Peaceman, which was released on DVD last August on Amazon; and another of his legendary costume parties at his castle on August 22nd to celebrate the success of The Peaceman Foundation.
On completion of our chat, Sir Ivan took me on a tour of the castle, and in doing so, we spent a lot of time at the pinball table, which was naturally castle-themed. It was here I realised that Sir Ivan really does have a boyish enthusiasm for life, and is really only looking to have fun, and also try to bring fun into other people’s lives. Everything is all very much tongue in cheek, and he has that charming ability to be able to laugh at himself, a rare trait in someone who is so lavishly wealthy.
We ended our meeting at the very top of the castle, amongst the turrets looking out over the five acres of greenery, with extended views to Robins Island and the Peconic Bay. Our final discussion was how children do indeed carry the burden of their parents’ pain, and how that not only drove him on, but in Sir Ivan’s own special way, he has used his influence and wealth to try and make this world a better place for others who may have suffered. He is indeed Peaceman – a real life Superhero. | 2019-04-25T14:50:08 | https://headlinermagazine.net/new-music/meeting-sir-ivan-the-peaceman.html |
I'm not sure that it is wise to judge national character on the basis of these postings on the Randon list--this was, after all, in response to a call for unusual tips. I would say that the balance between parochial and cosmopolitan types is about the same in the US as it is in the UK--at least among randoneurs.
I find myself looking at a lot of these discussions from both ends. I like to over-analyse things, in a Germanic fashion, but I'm located among people who don't. There a resonance for me in some descriptions of US Southerners.
Nisbett argues that many of the cultural traits of the modern South can be traced back to the heritage of the population's descendants. "The Scots-Irish were a herding people, while people from the north [of the U.S.] were English, German and Dutch farmers. Herding people are tough guys all over the world, and they are that because they have to establish that you can't trifle with them, and if you don't do that then you feel like you're at risk for losing your entire wealth, which is your herd. This creates a culture of honor, and the Scots-Irish are very much a culture of honor, and they carried that with them from the Deep South to the Mountain South, and then out through the western plains.
Culturally I don't identify with the mass of people between the rational and emotional extremes. In the USA the academic tradition is heavily influenced by the German idea of 'Bildung'.
Most explicitly in Hegel’s writings, the Bildung tradition rejects the pre-Kantian metaphysics of being for a post-Kantian metaphysics of experience that rejects universal narratives.
In this way, fulfillment is achieved through practical activity that promotes the development of one’s own individual talents and abilities which in turn lead to the development of one’s society. In this way, Bildung does not simply accept the socio-political status quo, but rather it includes the ability to engage in a critique of one’s society, and to ultimately challenge the society to actualize its own highest ideals.
So working to a goal through earnest enquiry is a US characteristic, more marked in those areas with Germanic/Scandinavian influence.
While to Brits, earnestness is a crime. In the US it's possible to get university course credits for it.
In the South, and in the rural upland UK, a respect for physical and emotional strength means that tasks such as Audax are closer to the 'natural' abilities of of the population. The same is true of Brittany, the Basque country and many other areas where pugnacity and toughness are valued. Look at Hinault for instance, as opposed to Fignon.
So my unusual tip is not to limit your potential pool of allies by riding with people who seem to be like yourself. Innate toughness can blend well with careful research, and the nature of the task sorts participants so that we are all more similar to each other than to people in general.
It's more important that allies share a common pace than similar attitudes. Paradoxically there's more potential for friction between those who share a language.
99% moronic USAian misinformation. For example: several people claim it's difficult to find food and drink on the route??!??
If there are 5000 riders at PBP, there are going to be 5000 different experiences. My experience as a 90 hour recumbent rider in 2011: people handing out water saved me during those brutally hot first few hours after the start, but the only food I could find on the first 220 km to Villaines that first night was a crepe stand 2 km before the control in Mortaigne. Even Mortaigne was out of bread to make jambon beurre when I was there at midnight. All the way to Brest I was riding surrounded by a swarm of cycling locusts, and I stopped in boulangeries that had nothing left to sell when I was there. Queues for hot food at controles were typically an hour long, and the food available was high protein and low carb, not what my starved body needed. So yes, for me it was harder to find food and drink on the PBP route than on any other audax I have done. My unusual tip for PBP is to avoid the 90 hour bulge if at all possible, and either ride with the 84 hour start or on the very latest 90 hour start. like the free starts of 2011. I learned my lesson, and I am going back next year and I plan to have a great time at PBP.
I'm hoping to go for the 80h hour group, riding fixed. This should make it much easier, they tell me.
One half of the first sentence makes a lot of sense when used in conjunction with the second sentence. The other half, well, I am having trouble with!
If I am not on the tandem, then I have two options currently - go for a time whilst I am still able to, or do it fixed for giggles. The two are not 100% incompatible, but I'd be on gears if I am going for a time.
If there are 5000 riders at PBP, there are going to be 5000 different experiences.
My unusual tip for PBP is to avoid the 90 hour bulge if at all possible, and either ride with the 84 hour start or on the very latest 90 hour start. like the free starts of 2011. I learned my lesson, and I am going back next year and I plan to have a great time at PBP.
i'm also pondering gears vs ss. the times on my previous audaxes are pretty much identical on both bikes, and the terrain on pbp is very suitable for riding single gear (no steep hills). the disadvantage of ss bike is that i'd need to tension the chain 3-4 times due to wear/stretch, wasting at least 5min!!!
If every rider took the oft heard advice to avoid the bulge then wouldn't the bulge just move???
Don't overthink it would be my advice. Just get on your bike and ride, see what happens. PBP is so very do-able. Easier in many respects than the qualifying 600 you will have done. There's food, showers, bed, mechanics, speech therapists, feng shui advisors, pedicurists... well, okay, I made some of that up but you get the picture... every 80 odd ish km. There's street stalls and individuals offering food and drink. You're pretty sorted really. Certainly in comparison to other rides.
The most likely issues will be your in head and physical tiredness. Expect to get tired and disoriented, it goes with the territory, but you're not alone. You push yourself through that because that's what you're there for. It's PBP. And it's fun... if you don't over complicate it!
It was much less tough on fixed in 2011 than on gears in 2007. There are so many other variables, though. In 2007 I had a gear-related mechanical which would not have happened on fixed (or if I'd replaced my cables before the ride).
PBP's not too hard on fixed. Where it got problematic was the final day was very flat, and that was tough. But I was in a far better state than at the same stage in 2007, where I was seeing double for a while. And you get people coming alongside and saying things like "Fixed gear, Carradice, no helmet - you must be British!".
I think I'll gear up a bit next year (75"+). The spinning on the long descents caused me some comfort issues by the last day in 2011.
Ideally we want to indoctrinate JUST the fastest 50% of riders with this "tip". That should smear out the bulge as much as is possible!
I've ridden PBP four times, in three of those I've been in the heart of the bulge.
In 2003 I was actively supporting Heather to get round, and ran close to the limit most of the time.
In 2007 and 2011 Heather followed me round on a Press pass. I met her at controls and she filmed while I slept, and brought me food when she woke me up.
it's interesting to observe the bulge when all your own anxieties about its effects are removed. It's easy to become overwhelmed by the difficulties of getting food and some sleep, and to start making bad decisions. If you remove those uncertainties it's a lot easier.
It is possible to flirt with the bulge, as it's where the heart of PBP is. But you need a get out of jail free card, which is either pre-arranged support, or the ability to up the pace and escape the chaos.
I explored some of the problems in 2007. The video only gets watched before PBP, so it needs waking up a bit.
Or simply the ability to ride fast enough between queues that you can still get plenty of sleep.
God I hate those people!
For me, the remarkable thing about randonneuring is the generosity one experiences, both from fellow riders, from organizers, and from the people along the road. I am not as experienced as some on this list, but I have had the good fortune of finishing five rides of 1200K or more--PBP in 2011, LEL and Super Brevet Scandinaivia in 2013, and the Cascade 1200K and Ronde Alienor d'Aquitaine in 2014. When I go into one of these rides, I figure that it is down to me to finish, and any help I receive along the way is an occasion for gratitude. Like others, I find food and drink plentiful on PBP--I would say one needs to exercise greater care going up mountain passes in Washington State or France, or in the Swedish countryside. Yes, toilet conditions on PBP controls can be trying, but that's only because so many riders are passing through--the good thing is that most French towns have public toilets near the church or the mayor's office. And I actually quite like the ambiance of PBP controls. When I arrived in Tinteniac in on the return in 2011, Sophie Matter was being interviewed with great flair by a local radio announcer, and the whole town seemed to have entered a state of unrestrained jubilation. The inefficiency of PBP controls is only a problem if you are trying to finish in a certain time, or if your time bank is running low. My answer to that problem is to try to keep enough time in the bank so that you don't have to worry about standing in line to fill your water bottle, but don't try to set a course record. Finding a happy middle ground makes PBP an entirely enjoyable experience.
"You don't have to go fast; you just have to go."
What size gear was that on?
I used 70" last time. Didn't have any trouble on the climbs although I did feel the Loudeac-Carhaix stretch a bit - both ways.
I was on 69" last time, and I'd use it again. I'd not gear down. I suppose I could gear up but there weren't too many troublesome descents for me.
I was pretty much in the bulge all of the way last time (see first figure at http://www.gicentre.net/blog/2013/10/31/lel). I don't recall it being problematic on the whole. The only problem I experienced as a consequence was not being able to get a bed at Carhaix on the way out. Certainly tails of hour-long queues for food didn't relate to my experience. Personally I wouldn't worry about that aspect of things.
As for riding fixed, I've done that the last two times and if I am able to enter next year will do so again. It's pretty fixed friendly on the whole. I'd have some caution in going for the 80 hour group though, not because of the time as such, but because it is much more challenging riding in a group at a faster pace if you are the only one on fixed, especially when other riders are not expecting it. On more than one occasion last time, I think the lack of freewheel noise and obvious stopping of moving legs made tired riders behind a little less responsive to slowing down. For the first time ever I actually received anti-fixed comments from other riders in PBP 2011, ranging from sarcy comments from fellow Brits (not all joking) to being told that fixed riders shouldn't be riding in a group with geared riders. Personally I prefer to ride either alone or with one or two others, doing my socialising at controls.
if you're slow enough to find PBP a challenge, ride faster!
For the first time ever I actually received anti-fixed comments from other riders in PBP 2011, ranging from sarcy comments from fellow Brits (not all joking) to being told that fixed riders shouldn't be riding in a group with geared riders.
That's one of the great things about PBP, people start saying what they actually think.
Assuming they speak the same language...Otherwise gestures and tone of voice have to be sufficient, e.g if someone cuts you up or nearly knocks you off.
I rode a 67" fixed in 1999. Gear seemed about right to me.
My experience from last time, on gears on the 80hr, was that not all the controls were fully set up. Because I wasn't among the fastest, there were no vacant beds at Brest (again, still setting things up).
Plenty people were quite happy to sit on my wheel and not take a turn.
I would say that the balance between parochial and cosmopolitan types is about the same in the US as it is in the UK--at least among randoneurs.
If by parochial you mean 'small-minded', then I'd say that's been my experience too.
Of the two PBP's I've done, by far the most satisfying memory I hold of of both rides [apart from actually just getting round] is interacting with all different types of overseas riders - some you understand, others you don't, some you like, some you don't. But nevertheless, the International aspect of the event is really fantastic. I really liked that side of the whole thing.
Entering with absurb generalizations about any race is going to be a limiting factor on how you see people.
Take people as you find them, and it can only add to the enriching experience of it all.
I quite like absurd generalisations as an opening gambit in a conversation at 4 in the morning, with the first person you've ever met from Tennessee.
You have to mention Dolly Parton, Tina Turner and Nutbush City Limits, before moving on to Al Gore and US environmental policy. Don't you? | 2019-04-18T18:42:35 | https://yacf.co.uk/forum/index.php?topic=86460.50 |
Emma Cotton graduated from Eckerd College in 2016, where she was the editor-in-chief of the student newspaper, The Current. After school, she moved to Vermont, where she wrote about artists, chefs, vineyards, rock climbers, bagpipe players and ice swimmers as the assistant editor for Vermont Sports and Vermont Ski + Ride magazines. She returns to St. Pete ready to embrace the sunshine. | 2019-04-24T06:22:23 | https://stpetecatalyst.com/author/emmacotton/ |
Assets like fine jewelry and gemstones can be invaluable to your net worth. They contribute to a large degree to your overall wealth. They also can be used as collateral if or when you need to secure a bank loan.
Because of their importance in your monetary standing, they may need to be appraised on a regular basis. You can have their values determined by taking them to a qualified jeweler, having them professionally appraised, or using jewelry appraisal software to determine what they are worth.
You might wonder when you should have your gemstones and fine jewelry appraised. It could be recommended that you have their values determined immediately after you receive or buy them if not sooner. In fact, some people like to have diamonds, gemstones, and fine jewelry appraised even before they purchase them for themselves or others.
This initial appraisal will determine the value of the asset you plan to include in your jewelry collection. You will have an initial dollar amount that ideally should be close to the amount for which it has been sold. You can then expect that amount to rise as the asset appreciates in value.
As your fine jewelry, gemstones, and diamonds age, they typically will increase in value as long as they have been well-kept. If they are not damaged or significantly altered, they may become even more valuable to you.
You can have them appraised after a few years of owning them to determine if they are increasing in value. Depending on the price that they are worth now, you might even decide to sell them to a jeweler or to someone else who wants to own fine assets like yours.
You may not have the time to walk into a jewelry store and have your fine jewelry appraised. You may need to make an appointment that will fit your busy schedule.
The website lets you schedule a time that accommodates your calendar. You can then have your gemstones, diamonds, gold, and other fine jewelry appraised so you can know its exact dollar value. | 2019-04-24T18:05:35 | http://www.1sthappyfamily.com/2018/08/determining-value-of-your-assets.html |
I am back at it and have found my next project. After selling my SMB last summer and regretting it, I have been looking for the right van ever sense. After having way too many vans in the past and selling them for various reasons. I have realized that MY van is not out there, so I am going to do a full custom interior build to suit my needs.
I found my "new" van down in New Mexico. It is a 2001 E350 EB Cargo with 60K miles and the 7.3L.
The plan is to add a hightop and do a full interior buildout. Then the 4x4 conversion will happen, hopefully this fall or winter.
Here is a now picture and there will be updates as projects happen. If all goes well, it will be camp-able in the next couple months. That way I can sell my current VW camper.
You bought the correct chassis and body---if the 7.3 is your engine of choice you did very well IMHO.
I recently acquired an '05 E350 extended body, 5.4 motor, was/is technically a Club Wagon but modified with the raised roof, extended height rear door and a wheel chair lift (since removed & discarded). Having had E250's previously I love the E350 much more.
I did add Hellwig super heavy duty front and rear sway bars. Next up will be Bilstein shocks for short wheel base motorhomes built on the E-Series chassis. They're already here, just need time and weather to swap them in.
Hope to see your build as it progresses!
Great score! Can't wait to hear more about the details of which high top and what interior floor plan you have in mind.
I just ordered a Tufport high top from Delta BC (kinda near ya), so we'll see how that one works out.
Congrats and nice find, looking forward to the build thread!
It is a 2001 E350 EB Cargo with 60K miles and the 7.3L.
Nice find. I am in awe of how people keep finding low mile 7.3's that aren't completely trashed in every other sense. Almost every low mileage one I found were complete rust buckets or damaged in some other way. Or priced so high it was laughable.
Well, I was looking daily for months and I did have to pay for this van... I don't believe I over paid but I probably paid a "Retail Dealer" price. Unfortunately the transmission promptly took a crap on me, so I get it back tomorrow with a fully rebuilt transmission with all of the possible upgrades.
My first part showed up! Thanks 1der!!!
If you're not already personally acquainted with the Door Talon/Claw you'll love it---I couldn't live without one myself!
Let us know you thoughts on these....does the rear swaybar hang below the axle? Is the improvement already very noticable?
I do indeed have both front and rear Hellwig bars installed, maybe 500 or so miles driving with them. I can say categorically any E-Series with a rear sway is noticeably improved first drive. I've not yet had time to install the Bilstein's but that's coming up soon.
Ride-wise I'm never sure how to answer that as its too subjective to the driver. Personally I'm far more concerned with safe and under-control the ride is, much more so over any "comfort". Do keep in mind all my miles are strictly paved roads and highways.
My E350 EB formerly Club Wagon now fully gutted is a bit stiff but once its refitted with about 2K additional weight it will be much less "bouncy" over the Ohio roads. Between the Hellwig bars and Bilstein shocks I'm confident the ride will still be "firm" which is what I'm after. Michelin LTX's E-rated 245 tires @70 psi front and rear will help too.
If any additional info, views or measurements are wanted please let me know. | 2019-04-25T11:42:19 | http://www.sportsmobileforum.com/forums/f24/2001-e350-eb-full-build-21527.html |
Thank you for visiting PrintableCursive.com!
1) Share it with your friends and followers – word of mouth plus sharing on Facebook, Twitter, Pinterest, or other social media sites — every share helps!
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This is not only a cursive writing printable pages…. It’s with lot of good useful information for my kid….
Can you please tell me the name of the Abeka style font? I need an alphabet line for my classroom, and I cannot find one in this font anywhere. I don’t mind creating my own, but I can’t find the font. Thank you!
Thank you for providing this! I’ve been looking for good pre-cursive materials for my daughter for awhile and this is the best I’ve found, so far. The more advanced pages should work really well for my 10 year old son, who really needs to improve his writing skills, too.
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So nice to have found your site. Which packets do you offer in Intermediate Abeka style.
I am excited about these Cursive Handwriting Printables with some of my classes. I printed them but must say, I was disappointed that some of the words printed with loopy symbols and some letters were left off of words. Is there a way to print as it’s dislayed??
Hi, Its me again! I just wanted to let you know that I shared links to your site on the AmblesideOnline.com forum for other homeschool families who are looking to teach their children cursive.
I am now in the middle of your 133-page packet with my almost-6-year-old son, and it is still wonderful. The way the packet is organized has helped him to naturally progress and improve just by following the order of the pages.
Thank you, again, for providing this resource for free! For a mom of 4, homeschooling for a one-income household, your cursive packets have been a God-send, and we are so thankful.
Wow, that is great to hear! I enjoyed making them, too.
It’s really helpful site . I’m glad I found it . Thank you .
Thank you for blessing us with your wonderful printables. I am homeschooling my son, who will “technically” be starting 3rd grade in the fall. He has started expressing a definite interest in cursive writing, and I am so thankful to have come across your site. Thank you for your generosity and I can’t wait for us to get started. I am certain he will enjoy them very much. | 2019-04-21T06:17:18 | http://printablecursive.com/support-donations/?replytocom=177 |
Logo design and Illustration was the first aspect of commercial art that drew me in. Most of my initial training was completed before digital design came to light. Business Cards are the best form of creating contacts and getting your brand out quickly. They are also one of the trickiest to design, given their small size. I have tried to pick the most diverse of what I have designed over the years to display. Click a thumbnail below for a closer look.
Package design is one of the hardest advertising to create. Trying to vie for position and attention on a shelf is one of the most difficult galleries around. I lack a number of decent photos of finished packaging to adequately display all my work online, So I tried to pick the most diverse of what I have to display. Select any project for a closer look. | 2019-04-26T12:00:24 | https://obriendesign.biz/branding-design |
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5. We offer a Low Price Guarantee on our ZCP wheels. | 2019-04-26T06:41:25 | http://www.modbargains.com/bmw-oem-e46-m3-zcp-wheels.htm |
You know, my wife and I worked hard over the years to create businesses that offer us flexibility.
We now have the privilege to take the time we want for our priorities.
Unfortunately, what that hard work didn’t do was exempt us from struggling as new homeschoolers.
We found ourselves up against the same, common questions many new homeschoolers face.
We constantly questioned if we were giving our son the right tools for success.
And if we weren’t, what then?
How could we turn it around?
We were grateful to have had like-minded parents to help us in our homeschool journey.
Because, for a long time, we wanted to dramatically improve our homeschooling, but we weren’t sure how. And talking to a lot of other homeschoolers, I see similar struggles. I hear similar questions.
Someone who has already gone through all the hoops.
Already bounced from one curriculum to the next.
That parent that has gone from a digital planner to a paper planner and then back to digital.
Because we have some flexibility with our time and we continue to work on improving this site to provide excellent content, we decided to conduct a research project.
But I can’t do this research project alone.
As much as I would love to be that one-parent crusader, it wouldn’t be very effective.
And I don’t think too many people would hear me.
So, I want to ask for your help. Hopefully, you won’t think I’m asking much: just 10 or 15 minutes to hear your advice.
My goal is to interview 50 homeschooling parents about what they are doing effectively in their homeschools. I’m calling this our Homeschool Help Research Project.
I would love if one of those 50 were you.
It doesn’t matter if you think your schedule still needs tweaking, your housekeeping systems need an overhaul, or your meal planning has fallen through the cracks.
I’d love to understand what works in your homeschool. What things you look forward to in your typical homeschool day.
When I’ve completed those 50 interviews (that won’t last longer than 15 minutes), I’m going to create a report.
That report is going to be filled with insights on how to effectively solve common problems encountered by new homeschoolers.
While you’re helping me to improve this site, I want to give that report to you as a thank you for your help in this mission.
I thought to limit this to 50 people so we have enough information to be meaningful but not so many interviews that I can’t manage all of the information and get it back you in a timely manner.
If you’re willing to help, just enter your email address at the bottom of the page to let me know you want in on this Homeschool Help Research Project.
I’m not asking you to purchase anything; I’m not even asking you to pay me for the phone call.
Our goal is to give new homeschool families a better chance of success (of course my wife and I will use the insights in our own homeschooling!).
I want to improve our site to help wipe out those same initial frustrations my wife and I felt.
Frustrations that are common but don’t have to be overwhelming.
Be one of the first 50 and the Homeschool Help Research report is yours, free of charge, as a thank you for your time.
Your input will be invaluable to new homeschoolers.
This was a segment done for our Perfect Homeschool Day webinar. It wasn’t recorded, so you won’t find this anywhere.
I’m creating a special recording it JUST FOR YOU.
That’s how much I value your time.
Again,if you’re interested, let me know your email address and we can set up a time to connect. The form is at the bottom of this page.
Previous Post Saint Patricks Day Homeschool Unit Study Next Post When Is It OK to be Too Busy to Homeschool? | 2019-04-26T06:45:09 | https://homeschool-curriculum.org/homeschool-help-research/ |
Online multiplayer and some features of Game DVR requires Xbox Live Gold subscription (sold separately). Stream to one device at a time; streaming with. Get up to $ in free games during a year of membership including backward compatible Xbox games for your Xbox One. JOIN XBOX LIVE GOLD. MICROSOFT'S Xbox Game Pass service allows Xbox One owners to play over + games for a set monthly price. Here's the list of all Xbox.
When downloaded, the game belongs to the user even if they subsequently drop their Xbox Live Gold membership. Two titles are. 21 Apr With the program, Xbox Live Gold members are eligible to receive Games with Gold is exclusive to the Xbox and, as of June , the. 4 days ago The excellent cult hit Vanquish is also available for Xbox and Xbox One. The May Xbox Live Games With Gold line-up has been. 30 Apr Below is a complete list of every Xbox One, and Xbox Live game available in Xbox Game Pass. Currently there are games - on. 2 Dec In all, there were 48 games in Xbox Live Games With Gold for , All Xbox games in Games With Gold are compatible with Xbox One.
17 Jan As a reward/incentive to keep up their subscription, Xbox Live Gold members get two free games a month to download for a limited time on both. 20 Apr Microsoft announces it will cease production of the Xbox , but don't despair: all of its services will continue uninterrupted. 26 Jan Here are all the free Xbox One and Xbox games for Microsoft's Xbox Live Gold subscribers in February. 23 Apr One of the main benefits of being an Xbox Live Gold subscriber is definitely the fact that each month you get access to a range of free games. | 2019-04-20T00:36:40 | http://matttalbotministries.com/arcade/how-to-games-for-xbox-360-live.php |
The maven module under service-permissions provides a generic permission handling database. Two db tables (oskari_resource and oskari_permission) are used to control access rights to layers and bundles.
The maplayer needs to be registered as a resource for permissions db (since the permission implementation is generic).
resource_type is a string reference to another table for example in this case oskari_maplayer.
resource_mapping is a table specific reference to the resource in question. For maplayers its url+name since this combination references to an actual unique service. The value could be the layer's id in oskari_maplayer, but then one could insert a layer for some url and then after receiving permissions change the layer to a completely different service (in this case the person granting permissions might be another than the one adding/modifying the actual layer).
external_type is a reference link for the external_id. Usually permissions are mapped for user roles so you the value is then 'ROLE' which means external_id is a role id. Another possible external_type is 'USER' which means external_id is a user id, but this isn't widely used or might not be supported in all cases. Recommented use for now is to only use ROLE mappings.
Adding layers is currently a generic permission (not mapped to data producer or similar). We need to add a resource for "generic-functionality".
There is an admin-layerrights bundle with which admins can set layers' permissions. Check adding bundles for how to add the bundle. When the bundle is added a role can be chosen and rights for that role for each layer can be set through the Layer Right view. | 2019-04-24T21:57:49 | http://oskari.org/documentation/backend/permissions |
Copies of birth certificates (Certified or Photocopy of Certified) showing parents’ full names. Certified copies of birth certificates are issued by the County Clerk or State Register and have an impressed court seal on them. Hospital certificates with foot prints on the back are not acceptable.
Foreign born applicants must provide a valid passport, permanent resident alien card, naturalization certificate or certified copy of a birth certificate (with English translation).
Fees may be paid by cash, check, money order, or credit/debit card. | 2019-04-23T18:11:30 | http://www.recyclesmart.info/1898/County-Resident-Applicants |
Rome, February 1st, 2013 The Board of Directors of Enel Green Power SpA (Enel Green Power), chaired by Luigi Ferraris, met today to review the preliminary consolidated results for 2012.
Total revenues of the Enel Green Power Group amounted to 2.7 billion euros, up 8.0% from the 2.5 billion euros posted in 2011. Both figures include non-recurring items. The growth in revenues amounted to 0.2 billion euros. Such an increase is mainly attributable to the sale of electricity resulting from higher output achieved in Iberia and Latin America, North America and the rest of Europe.
EBITDA totalled 1.7 billion euros, an increase of 6.3% compared with the 1.6 billion euros registered in 2011. Both figures include non-recurring items.
Net financial debt was 4.7 billion euros, at the end of 2012 up about 0.6 billion on the 4.1 billion euros posted at the end of 2011.
Employees at the end of 2012 numbered 3,513 (3,230 at the end of 2011).
Group net installed capacity at the end of 2012 totalled 8.0 GW, of which 2.6 GW (33%) hydro, 4.3 GW (54%) wind, 0.8 GW (10%) geothermal, 0.2 GW (2%) solar and 0.1 GW (1%) from other renewable energy resources (biomass and cogeneration). Compared with December 31st, 2011, net installed capacity increased by 0.9 GW (+13%)2 mainly in the wind segment.
Net electricity generated by the Group in 2012 amounted to 25.1 TWh, of which 9.9 TWh (39%) hydro, 9.0 TWh (36%) wind, 5.5 TWh (22%) geothermal, 0.2 TWh (1%) solar and 0.5 TWh (2%) from other renewable energy resources (biomass and cogeneration).
Power generation increased by 2.6 TWh (+12%) compared with 2011, mainly attributable to higher installed wind capacity, offset by a decrease in hydro generation owing to lower water availability.
The following section describes a number of alternative performance indicators, not envisaged under the IFRS-EU accounting standards, which are used in this press release in order to facilitate the assessment of the Groups performance and financial position.
- Total revenues: calculated as the sum of "Revenues" and "Net income/charges) from commodity risk management".
- Net financial debt: an indicator of Enel Green Powers financial structure, determined by Long-term loans, the current portion of such loans, Short-term loans, less Cash and cash equivalents and Current financial assets and Non-current financial assets not considered in other balance sheet indicators.
The officer responsible for preparing the companys financial reports Giulio Antonio Carone declares, pursuant to paragraph 2 of Article 154-bis of the Consolidated Law on Finance that the accounting information contained in this press release corresponds to the document results, books and accounting records. | 2019-04-24T17:45:59 | https://corporate.enel.it/en/media/press/d/2013/02/enel-green-power-announces-preliminary-consolidated-results-for-2012- |
Thinking about a retreat in Bali?
It’s all too easy to let our fitness and health routine slide. But the reality is if we don’t put ourselves first, we could be heading for a trainwreck. Thankfully, wellness retreats are having a moment – especially on the island of Bali where there are so many inspiring options. So whether you’re craving a wellness weekender, a rustic getaway, a luxury yoga retreat, or a serious cleanse to get you back on track, here’s our tried and tested recommendations for 2017.
When luxury calls, Como Shambhala Estate is Bali’s most esteemed wellness destination. Simply put; facilities, programs, and treatments are first class. Check into a Retreat Villa and hand your being over to their team of TCM, Ayurveda and yoga experts – you’re in good hands!
Fivelements is a wellness sanctuary with elegant riverside villa, sustainable facilities, and 100% plant-based cuisine. Explore healing and detox retreats and experience spiritual treatments bestowed by Balinese healers including fire ceremonies and water blessings.
Fivelements is a wellness sanctuary with sustainable facilities.
When you seek a retreat that feels nourishing and grounding then a Panchakarma detox at Oneworld Ayurveda is for you. Offering gorgeous accommodation and wellness facilities, your program consists of daily consultations with the Ayurvedic doctors, twice-daily nurturing treatments and meals tailored to your dosha. A Panchakarma is a life-changing experience for many!
Why not add on a healing retreat with your luxury pool villa when staying at the Four Seasons Sayan. It’s five-star service all the way, their treatments are some of the finest on the island – sublime! Book in for a sacred nap while you’re there, trust us.
Down-to earth Desa Seni is where you stay in traditional houses set around organic gardens, a salt water pool and yoga shalas. Stretch your limbs, juice cleanse and chant with like-minded souls from all around the world.
Oneworld Retreats is an affordable destination that appeals to those who seek quality yoga, ricefield walks and temple visits. There’s an optional silent day with a highpoint, their Chakra Dhara – one of the best treatments In Bali.
Explore programs including ‘Sleep’, ‘Silence’, and ‘Quit Smoking’ at the newly launched Svarga Loka Resort. This retreat houses a detox clinic and riverside spa with unique experiences including kundalini yoga and full moon meditations.
Peppers Seminyak is a boutique resort that works when you want to be nearby the beach and Seminyak’s glitz and glamour. Your juice detox programs can be enhanced by resident consultants, and fitness experts and medi-spa services.
Located in Canggu, this is one for the girls. Enjoy learning to surf, sunset yoga, healthy meals and day trips to local sites. Perfect for solo travellers, mothers and daughters and time with the girls.
Set on a black sand beach in Sanur, Hotel Komune appeals to those who like to mix up their yoga with surf, spa – with a sunset beer! Their healthy cuisine and spa are nicely affordable and why not bring the entire family – the kids club is epic.
Insider tip: with HOTEL KOMUNE you can bring the kids (their kids’ club is epic).
You can also bliss out in Bali with these celebrity-led retreats which regularly pop up on the retreat schedule. Popular are Amanda’s www.amandajanelife.com yoga and nutrition retreats. Australia’s best selling yoga author, Jessie Chapman of https://radianceretreats.com hosts a yoga and spa retreat and Sunset Pilates is about to launch a series of Pilates retreats – we can hardly wait!
BECOME A YOGA TEACHER – at a retreat!
THE SHALA BALI is a retreat destination that also offers the opportunity to become a yoga teacher. Sleep in beautifully appointed villas with organic gardens, an infinity pool and Ayurvedic spa. | 2019-04-18T23:05:47 | https://www.threesixtyguides.com/featured/bali-retreat-hotlist-2017/ |
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Some grandma story about Victoria Station—->> The first station was Station Damansara, then here comes the Station Ampang, Station USJ, Station PJ and up north to two stations in Penang – Station Bayan Baru and Station Seberang Jaya later on.
You will easily notice Victoria Station if you pass by Jalan Ampang because of the attracting classic train head. According to my mum, the train was real. Haha..
The interior building looks like the old British castle.
A very unique and the cozy ambience, suitable for couples dining or friends gathering or business dinner. But today, I saw mostly was family instead of couples.
Here goes another train inside the building. Im not sure if this one was real too.
You can also request to sit inside the train to have your meal. It will be a special experience.
Premium Australian Grape Juice. We did not order that. It was already served on the table once we sat down.
My dad’s order. The plate came with deep fried supreme of chicken, garnished with sausage and top with banana fritters. The chicken is crispy outside, oozing with juiciness and tenderness inside. The sausage was ordinary and the banana fritter is odd to appear in a western plate. The corn and fries provide a portion of carbohydrate while the vegetables were good enough to balance up the oiliness of the chicken.
And this was my mom’s order. A plate which was simpler with premium fish fillet, chips and salad. The fish fillet was well seasoned, breaded and fried to perfection. The fillet might not look appealing, but the breaded outer layer brought up the boring taste of usual fish and chips, making it more flavorful. Having the fish fillet together with the traditional VS Tartar sauce dipping made my mum gave another double thumbs up to this dish.
Being greedy to get a taste of lamb and salmon, my little brother and I ordered this. The plate came with an iresistable combination of imported salmon and grilled lamb loin, served with potato of the day and salads. The salmon was very fresh but the bone within the salmon made it a letdown..=.= . I like the lamb loin very much as it did not have overly strong lamb smell. The chef did a good job in preparing it as the lamb was well marinated, tenderly cooked, and a few slight chew already brought it down to my throat. Awesome. This dish worth with the price!
Happy Father’s Day to my dad and to all the father in the world!
Nice ambiance and the food is ok for me depending on what we choose to try out.
I am staying in Subang and my girl friend was staying in Damansara..We want to go for dinner tonight at Victoria Station for candle dinner..Please is their any idea which Victoria Station we should go that will e convenient for me and her? | 2019-04-21T20:58:07 | http://www.malaysianflavours.com/2011/06/victoria-station-jalan-ampang.html |
This single level commercial building at 108 Stirling Street, Perth was purchased by Stirling Capital in 2012 at an initial yield of 8.2%. It offered strong development potential in a high quality location. The existing 5 year lease (with a 5 year option) was held by the Commissioner for Main Roads with a total land area of 2,266sqm.
Development approval was secured for 168 apartments. The property was sold early 2015 with the investment providing strong returns above those forecast to investors. | 2019-04-20T12:50:34 | http://www.stirlingcapital.com.au/project/108-stirling-street/ |
Whether you are a businessman or a visitor from UK, there are several things that you need to know beforehand. Unlike several places in the world, Dubai immigration authority has kept entering and exiting the city quite simple. You can enter Dubai even when you have two or more passports. If you are a businessperson, you may often be looking for a swift entry into several countries around the world. To make is easy, you should apply for a second passport so that you don’t run into any troubles while entering any destination.
The process from writing to processing the application for a second passport is fast, provided you have related documents at your disposal. If not, the consultancy firm might ask you to submit all documents by a certain deadline. Off course, carrying required documents will only help accelerate the process and you will have the second visa in your hands sooner than later. Keep in mind the getting the second visa, UK in this case, is subject to the permission and verification of UK embassy in Dubai.
Having a secondary passport can bring you many advantages. Holder of the second passport offers you several advantages. For instance, you can move to another country whenever you want without having to explain the reason. Also, a second passport also helps you during frequent travels to various destinations across the world. During turmoil or political unrest in your country, you can use the second passport to leave for that country with your family. In other words, there are countless benefits of having a second passport. It would be better if you could apply for UK passport as your second destination. Doing so will allow you to make business and casual trips to UK. Just fill out the second passport cyprus and wait for the process to complete.
Are audits really good for a company? | 2019-04-25T01:47:54 | http://dailyswadsugandh.com/travel-and-tourism/things-you-should-know-about-passport-and-immigration-to-dubai/ |
The US president is reluctant to concede that the travel ban is not the silver bullet he made it out to be. Such restrictions are futile in the face of a dynamic, transnational ideology.
The attack in New York on Tuesday afternoon, in which eight people were killed and at least a dozen others injured, is a timely reminder that despite the battlefield victories in Mosul, Raqqa and elsewhere, the threat of Islamist-inspired terrorism remains.
The 29-year-old suspect reportedly drove his rented vehicle 14 blocks before crashing into a school bus before emerging with two replica firearms. The suspected attacker, identified as Sayfullo Habibullaevic, an Uzbek national who legally moved to the US in 2010, was taken to hospital after being shot and wounded by police officers and is expected to survive.
While there has been no immediate claim of responsibility, authorities investigating the attack have said that a note written in a foreign language pledging allegiance to Isis was discovered in the vehicle. As expected in such cases, there has also been celebratory activity on jihadi communications platforms, with supporters and sympathisers praising the attack.
The description of Sayfullo Habibullaevic being a lone wolf attacker is premature and potentially misleading.
While the individual may have acted alone, experience from previous investigations into similar attacks suggests the likelihood that a broader, loose network could be involved.
The act is often conducted by a single attacker, but often other individuals, whether through physical or digital interactions, provide an environment for the extremist ideas to flourish and such actions encouraged.
While it is not known whether Habibullaevic had links to any known jihadi groups, he comes from a country that is no stranger to jihadi activity. The Islamic Movement of Uzbekistan (IMU), established in 1991, has sought to overthrow the Uzbek government and replace it with an Islamic government to rule by a strict interpretation of Sharia law.
However, government crackdowns saw the group disperse and broaden its area of operations, particularly in neighbouring Afghanistan and Tajikistan, where the group had been active in forming alliances with other jihadi groups such as al-Qaeda and the Taliban. The IMU was designated a terrorist organisation by the United Nations in 2001.
Months after the declaration of Isis’ so-called caliphate in Syria and Iraq, militants belonging to the IMU were among the first to pledge allegiance to the group, with an online statement issued by a senior leader of the group praising Isis for its disregard for international borders, hoping that the group would one day seize control of Palestine and the Islamic holy cities of Mecca and Medina.
Isis has been cognizant of its large audiences in Russia and Central Asia, with propaganda material, including Rumiyah magazine, circulated in the Russian language. While not on the same scale as attacks in Western Europe, there have been several small-scale attacks in Russia and the Former Soviet Republics claimed by Isis.
Figures from the United Nations Development Programme (UNDP) show that around 500 foreign fighters from Uzbekistan have travelled to join Isis, while a report published in October 2017 by the Soufan Group suggests a higher estimate, with around 1,500 Uzbek nationals believed to have travelled to join Isis in Iraq and Syria.
The same report also determined that the proportion of regional foreign fighters from Former Soviet Republics was more than any other region, with over 8,000 individuals believed to have travelled to join the so-called caliphate, more than the number of foreign fighters from the Middle East (7,054) and Western Europe (5,718).
Given that Uzbekistan doesn’t feature on President Trump’s list of banned countries, judging from his response, stating that we must not allow Isis to return or enter the US after defeating them in the Middle East, the President is reluctant to concede that the travel ban is not the silver bullet he made it out to be. Such restrictions are futile in the face of a dynamic, transnational ideology.
The reality is that what connects Isis in Syria and Iraq to the insurgency in the Philippines, Nigeria, Afghanistan, and Egypt, and to the attacks we have witnessed in London, Manchester, Paris, Nice, Berlin, and Barcelona is not necessarily a tangible operational link, but rather a worldview, a set of ideas.
If only an operational link existed. We could end this in a matter of months, if not weeks. Unfortunately, the battle against the ideology connecting them all will be a generational struggle.
An ideology that cherry picks and manipulates Islamic scripture, seeks to divide the world between “believers” and “non-believers”, driven by a desire to implement by force a narrow articulation of Islam, alien to the majority of the world’s Muslims, and to eliminate any element of integration and coexistence between Muslims and non-Muslims.
Defeating Isis militarily is an important step in the fight against terrorism, but there is a bigger battle taking place, where men, women, and children, from all ethnicities and backgrounds, are being attracted to the closed-minded worldview of Islamist extremism.
Overcoming this threat needs more than physical security measures. Bullets and bombs cannot defeat an idea; travel bans cannot contain a borderless ideology. An open-minded approach that deals with the symptomatic violence and the underlying ideas must be the way forward.
This op-ed was first published in the Independent. | 2019-04-23T12:53:50 | https://institute.global/insight/co-existence/despite-battlefield-victories-threat-islamist-inspired-terrorism-remains |
A very interesting product has launched as the EA SYLOG-USB-1, the world's first battery powered temperature data logger with a direct USB interface. Using the Windows compatible software supplied, the EA SYLOG-USB-1 can be configured to measure temperatures from -25 to +80°C (-13 to +176 F). User selectable logging intervals from 10 seconds to 12 hours and a memory capacity of more than 16,000 readings make this data logger ideal for many temperature dependant industrial and consumer applications. The logger's housing provides an IP67 rated waterproof seal enabling the product to be used in harsh environments. The EA SYLOG-USB-1 has user programmable high and low temperature alarms, which are shown locally by a bright red LED and can be set to remain active once an alarm level has been triggered. Additional green and amber LEDs inform the user of other logger conditions, including memory capacity and battery status. All readings are stored in non-volatile memory ensuring important data is never lost. Simply plug into a USB socket on a PC for instant download and graphing of logged data. Once the data has been downloaded, the logger can be instantly reconfigured to begin the next application. The EA SYLOG-USB-1 and some other data loggers in the same style for humidity, carbon monoxide, voltage and loop current 4~20mA are available immediately from ELECTRONIC ASSEMBLY. | 2019-04-21T14:28:32 | https://www.lcd-module.com/news/jahresrueckblick-2006/a-hot-look-for-a-cool-logger.html |
I strongly encourage teaching children to be independent at daily tasks. If you live in a place that gets cold, every parents knows how tedious putting children’s coats on becomes. By age 3, it is reasonable that children get their own coats on (not zipped or snapped, but at least on). However, the spatial awareness to get a coat on is hard to learn for young children. I learned from a kindergarten teacher a trick that helps young children master this task- the coat flip.
The typical problem that occurs is that kids forget to stand by the hood side, but this can be corrected through practice.
Even a 2 year old can do it!
Pairing the coat flip trick with my previous post on how to help your child put their shoes on the correct feet can greatly increase children’s independence with dressing for outdoors (and decrease the demands on parents!).
Paige Hays is an occupational therapist who provides in-home, pediatric occupational therapy services in the south metro area of the Twin Cities, MN. She is a mother of 2 girls, avid DIYer, and a highly skilled and experienced OT. She specializes in working in pediatrics, with diverse expertise ranging from cognition and sensory issues to working with children with neuromuscular disabilities or complex medical needs. | 2019-04-22T10:26:31 | http://paigehays.net/everyday-simple-idea-16-coat-flip/ |
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