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protocolSection identificationModule nctId: NCT06292546, orgStudyIdInfo id: ZYC-Hp2024, briefTitle: Effect of Intestinal Microecology After HDDT Combined With Probiotics for Helicobacter Pylori Eradication, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04-01, primaryCompletionDateStruct date: 2024-09-01, completionDateStruct date: 2024-09-01, studyFirstPostDateStruct date: 2024-03-05, lastUpdatePostDateStruct date: 2024-03-07, sponsorCollaboratorsModule leadSponsor name: Zhongshan Hospital (Xiamen), Fudan University, class: OTHER, descriptionModule briefSummary: The aim of this study was to evaluate the effect of Intestinal microecology after high dose dual therapy combined with probiotics for Helicobacter pylori eradication, conditionsModule conditions: H Pylori Infection Eradication, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 80, type: ESTIMATED, armsInterventionsModule interventions name: Vonorason, interventions name: Amoxicillin, interventions name: Bacillus subtilis enteric-coated capsules, outcomesModule primaryOutcomes measure: Gut Microbiota, secondaryOutcomes measure: Fecal metabolites, secondaryOutcomes measure: Eradication rate, secondaryOutcomes measure: Frequency of the adverse events, secondaryOutcomes measure: Compliance rate of the drugs, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 65 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False |
protocolSection identificationModule nctId: NCT06292533, orgStudyIdInfo id: UTAR-30-2024, briefTitle: Effectiveness of Ultrapulse for the Treatment of Androgenic Alopecia Among Malaysian: A Quasi-experimental Study, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-03, primaryCompletionDateStruct date: 2024-10, completionDateStruct date: 2024-10, studyFirstPostDateStruct date: 2024-03-05, lastUpdatePostDateStruct date: 2024-03-05, sponsorCollaboratorsModule leadSponsor name: Universiti Tunku Abdul Rahman, class: OTHER, descriptionModule briefSummary: The goal of this study is to to evaluate the effectiveness of Ultrapulse for the treatment of androgenic alopecia among Malaysian. The main questions it aims to answer are:* the efficacy of Ultrapulse in treatment of androgenic alopecia among Malaysian* the safety and adverse effect of Ultrapulse treatment.* the quality of life of androgenic alopecia among Malaysian., conditionsModule conditions: Androgenic Alopecia, conditions: Alopecia, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NON_RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: SINGLE, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 92, type: ESTIMATED, armsInterventionsModule interventions name: Er:YAG laser, outcomesModule primaryOutcomes measure: Global assessment of hair growth, secondaryOutcomes measure: Patient satisfaction, secondaryOutcomes measure: Quality of Life of Patient, secondaryOutcomes measure: Adverse effects, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False |
protocolSection identificationModule nctId: NCT06292520, orgStudyIdInfo id: 4847, briefTitle: Comparison of ABLLS-R and Portage Guide in the Development of Receptive Language Skills Autism Spectrum Disorder., statusModule overallStatus: COMPLETED, startDateStruct date: 2023-06-10, primaryCompletionDateStruct date: 2023-08-20, completionDateStruct date: 2023-12-10, studyFirstPostDateStruct date: 2024-03-05, lastUpdatePostDateStruct date: 2024-03-05, sponsorCollaboratorsModule leadSponsor name: Riphah International University, class: OTHER, descriptionModule briefSummary: Language is the system someone uses to communicate with another person. This covers the origins and construction of words, their definitions, and the use of language in various contexts. In normally developing children, receptive language skills are typically much more advanced than expressive language skills. However, some studies found that toddlers and kids with ASD had a relatively greater impairment in receptive language skills than in expressive language skills. The study will evaluate the ABLLS-R (Assessment of Basic Language and Learning Skills test) and Portage guidance and compare their effectiveness in developing the Receptive Language Skills in children with Autism Spectrum Disorder (N=12).The study will follow the Randomized control trial study design and a purposive sampling technique will be used. Data will be collected from a special education centre BASES (Behaviour and special education services), Lahore. Children with autism spectrum disorder with mild to moderate severity level will be included in the study. The age range of the children will be from three years to seven years. Children with other neurological disorders or any comorbid conditions will be excluded from the study. The consent form will be filled out by parents of children who meet the inclusion criteria. The autism screening tool will apply by the speech and language pathologist. Half of the total number of children will receive therapeutic intervention under ABLLS-R protocol and other will receive Interventions under portage guide protocol. The data will be analysed by using SPSS 22 statistical software. The results of the study of both the groups will be compared and conclusion will be made on the basis of results. Receptive language skills are crucial for communication and social interaction. Research comparing these assessment tools can contribute to the development of more effective early intervention programs for children with ASD. By identifying the most appropriate assessment tool and intervention strategies, these programs can be better designed to support early language development and promote better long-term outcomes. By understanding the strengths and limitations of each assessment tool, professionals can create more individualized treatment plans for children with ASD, conditionsModule conditions: Autism Spectrum Disorders, conditions: Non-verbal Learning Disorder, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: OTHER, maskingInfo masking: SINGLE, whoMasked: PARTICIPANT, enrollmentInfo count: 12, type: ACTUAL, armsInterventionsModule interventions name: Portage Guide Protocol, interventions name: ABLLS-R protocol, outcomesModule primaryOutcomes measure: ABLLS-R for the development of receptive language in children with Autism, primaryOutcomes measure: Portage Guide for the development of receptive language in children with Autism, eligibilityModule sex: ALL, minimumAge: 3 Years, maximumAge: 7 Years, stdAges: CHILD, contactsLocationsModule locations facility: Bases Institute, city: Lahore, state: Punjab, zip: 05309, country: Pakistan, geoPoint lat: 31.558, lon: 74.35071, hasResults: False |
protocolSection identificationModule nctId: NCT06292507, orgStudyIdInfo id: REC/RCR&AHS/23/0734, briefTitle: Comparative Effects of Myofascial Stretch and Contract-relax in Children With Spastic cp, statusModule overallStatus: RECRUITING, startDateStruct date: 2023-12-01, primaryCompletionDateStruct date: 2024-03-16, completionDateStruct date: 2024-03-25, studyFirstPostDateStruct date: 2024-03-05, lastUpdatePostDateStruct date: 2024-03-05, sponsorCollaboratorsModule leadSponsor name: Riphah International University, class: OTHER, descriptionModule briefSummary: Cerebral palsy (CP) is primarily a neuromotor disorder that affects the development of movement, muscle tone and posture.It is one of the three most common lifelong developmental disabilities, the other two being autism and mental retardation causing considerable hardship to affected individuals and their families. CP is a common problem, the worldwide incidence being 2 to 2.5 per 1000 live births. Myofascial therapy is definable by "the facilitation of mechanical, neural and psycho physiological adaptive potential as interfaced by the myofascial system". The PNF contract-relax technique consists of stretching the target muscle, keeping it in position while the patient isometrically contracts it and relaxes in sequence, producing effects such as maintenance and gain in joint mobility, increased muscle strength, and better motor control whereas The modified Ashworth scale is the most universally accepted clinical tool used to measure the increase of muscle tone This study will be randomized clinical trial and will be conducted in Rasool medical centre Gujrat and City hospital Gujrat. This study will be completed within duration of 6 months after the approval of synopsis.Convenience sampling technique will be used to collect the data. A sample size of total 20 patientswill be taken in the study. 20participants will be equally divided into two group's myofascial stretch and contract-relax stretching techniques having 10participants in each group. Informed consent will be sought from them and they will be clearly explained about the purpose of study.Myofascial Stretching will be applied to Group A and Contract-Relax stretching will be applied to Group B.Results will be analyzed on SPSS., conditionsModule conditions: Cerebral Palsy, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: OTHER, maskingInfo masking: NONE, enrollmentInfo count: 22, type: ESTIMATED, armsInterventionsModule interventions name: MYOFASCIAL STRETCH, interventions name: CONTRACT-RELAX TECHNIQUE, outcomesModule primaryOutcomes measure: Manual Ability Classification system, eligibilityModule sex: ALL, minimumAge: 6 Years, maximumAge: 12 Years, stdAges: CHILD, contactsLocationsModule locations facility: Mirza Muhammad Farooq, status: RECRUITING, city: Gujrāt, state: Punjab, zip: 50700, country: Pakistan, contacts name: imran Amjad, PhD, role: CONTACT, phone: 033224390125, email: [email protected], contacts name: Muhammad asif Javed, MS, role: CONTACT, phone: 03224209422, email: [email protected], geoPoint lat: 32.5742, lon: 74.07542, hasResults: False |
protocolSection identificationModule nctId: NCT06292494, orgStudyIdInfo id: 1129052082, briefTitle: Focused Ultrasound for Drug-resistant Epilepsy, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-01-01, primaryCompletionDateStruct date: 2024-12-31, completionDateStruct date: 2027-12-31, studyFirstPostDateStruct date: 2024-03-05, lastUpdatePostDateStruct date: 2024-03-05, sponsorCollaboratorsModule leadSponsor name: Taipei Veterans General Hospital, Taiwan, class: OTHER_GOV, collaborators name: InSightec, descriptionModule briefSummary: Focused ultrasound (FUS) has been shown to differentially lesion or modulate (excite and inhibit) brain circuit and neural activity across a broad range of acoustic stimulus parameters (intensity, duty cycle, pulse repetition frequency and pulse duration) for decades. From our previous study, FUS sonication may suppress the number of epileptic signal bursts observed in EEG recordings after the induction of acute epilepsy. The presence of the suppressive effect was found in terms of the number of epileptic EEG spikes from the analysis of the unfiltered and theta-band EEG activity, and further discontinue the seizure attacks. EEG activity has also been consistently reported to have a positive correlation with the level of epilepsy, and FUS-mediated reduction of epileptic EEG activity was most notably observed, no matter lesioning or modulating effects. The aims of this study are to demonstrate the safety and efficacy of FUS technology in epilepsy patients and to estimate the optimal parameters of focused ultrasound exposure that will be used in the case of epilepsy., conditionsModule conditions: Focused Ultrasound, conditions: MR-guided FUS, conditions: Drug Refractory Epilepsy, conditions: Drug Resistant Epilepsy, conditions: Medication Resistant Epilepsy, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NA, interventionModel: SINGLE_GROUP, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 20, type: ESTIMATED, armsInterventionsModule interventions name: Exablate 4000 Transcranial MRgfUS System, outcomesModule primaryOutcomes measure: pulse rate [Safety], primaryOutcomes measure: blood oxygen saturation level [Safety], primaryOutcomes measure: MRI [Safety], primaryOutcomes measure: Incidence of Treatment-Emergent Adverse Events [Tolerability], secondaryOutcomes measure: seizure frequency [efficacy], secondaryOutcomes measure: scalp EEG [efficacy], secondaryOutcomes measure: No. of seizure-free days [efficacy], eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Taipei Veterans General Hospital, status: RECRUITING, city: Taipei, country: Taiwan, contacts name: Cheng-Chia Lee, MD. PhD., role: CONTACT, email: [email protected], geoPoint lat: 25.04776, lon: 121.53185, hasResults: False |
protocolSection identificationModule nctId: NCT06292481, orgStudyIdInfo id: REC/RCR&AHS/23/0240, briefTitle: Combine Effects of Brunnstorm Movement Therapy and LLLT in Chronic Stroke Patient, statusModule overallStatus: COMPLETED, startDateStruct date: 2023-08-01, primaryCompletionDateStruct date: 2023-09-30, completionDateStruct date: 2023-10-10, studyFirstPostDateStruct date: 2024-03-05, lastUpdatePostDateStruct date: 2024-03-05, sponsorCollaboratorsModule leadSponsor name: Riphah International University, class: OTHER, descriptionModule briefSummary: The primary objective of this study is to determine the combined effects of Brunnstorm movement therapy and low level laser therapy on upper limb function in chronic stroke patient., conditionsModule conditions: Chronic Stroke, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: DOUBLE, whoMasked: PARTICIPANT, whoMasked: INVESTIGATOR, enrollmentInfo count: 48, type: ACTUAL, armsInterventionsModule interventions name: Brunnstorm movement therapy, interventions name: Combined Brunnstorm Movement therapy and low level laser therapy, outcomesModule primaryOutcomes measure: Fugle meyer Assessment test, primaryOutcomes measure: Box and block test, primaryOutcomes measure: Nine peg hole test, primaryOutcomes measure: to check Muscle tone, primaryOutcomes measure: to measure grip Strength, eligibilityModule sex: ALL, minimumAge: 40 Years, maximumAge: 60 Years, stdAges: ADULT, contactsLocationsModule locations facility: Govt. Mian Munshi DHQ Teaching hospital, city: Lahore, state: Punjab, zip: 54000, country: Pakistan, geoPoint lat: 31.558, lon: 74.35071, hasResults: False |
protocolSection identificationModule nctId: NCT06292468, orgStudyIdInfo id: REC/RCR&AHS/23/0238, briefTitle: Plantar Cutaneous Sensory Stimulation in Patients With Diabetic Neuropathy, statusModule overallStatus: COMPLETED, startDateStruct date: 2023-07-07, primaryCompletionDateStruct date: 2023-08-18, completionDateStruct date: 2023-09-18, studyFirstPostDateStruct date: 2024-03-05, lastUpdatePostDateStruct date: 2024-03-05, sponsorCollaboratorsModule leadSponsor name: Riphah International University, class: OTHER, descriptionModule briefSummary: To determine the effects of plantar cutaneous sensory stimulation on foot tactile sensitivity, postural control, and spatiotemporal gait parameters in patients with diabetic neuropathy., conditionsModule conditions: Diabetic Neuropathies, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: DOUBLE, whoMasked: PARTICIPANT, whoMasked: INVESTIGATOR, enrollmentInfo count: 50, type: ACTUAL, armsInterventionsModule interventions name: Traditional physical therapy, interventions name: Plantar cutaneous sensory stimulation, outcomesModule primaryOutcomes measure: Foot tactile sensitivity, primaryOutcomes measure: Postural control, primaryOutcomes measure: Spatiotemporal gait parameters, eligibilityModule sex: ALL, minimumAge: 45 Years, maximumAge: 67 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: PhysioFit, city: Faisalabad, state: Punjab, zip: 38000, country: Pakistan, geoPoint lat: 31.41554, lon: 73.08969, locations facility: Allied Hospital Faisalabad., city: Faisalābad, state: Punjab, zip: 38000, country: Pakistan, geoPoint lat: 31.41554, lon: 73.08969, hasResults: False |
protocolSection identificationModule nctId: NCT06292455, orgStudyIdInfo id: RIPHAH/RCRS/REC/00713, briefTitle: Association of Anthropometrics With Grip Strength and Smash Quality Post Six Week Elastic Resistance Training, statusModule overallStatus: COMPLETED, startDateStruct date: 2020-07-10, primaryCompletionDateStruct date: 2020-11-30, completionDateStruct date: 2020-12-15, studyFirstPostDateStruct date: 2024-03-05, lastUpdatePostDateStruct date: 2024-03-05, sponsorCollaboratorsModule leadSponsor name: Riphah International University, class: OTHER, descriptionModule briefSummary: To determine the association of hand and forearm anthropometrics on grip strength and forehand smash quality of badminton players after six-weeks of elastic resistance training., conditionsModule conditions: Anthropometric Measurements and Elastic Resistance Training, conditions: Sports Physical Therapy, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: BASIC_SCIENCE, maskingInfo masking: NONE, enrollmentInfo count: 20, type: ACTUAL, armsInterventionsModule interventions name: Elastic resistance training, interventions name: Conventional Resistance Training, outcomesModule primaryOutcomes measure: Smash quality (Power), primaryOutcomes measure: Smash quality (Speed), primaryOutcomes measure: Smash quality (Distance), eligibilityModule sex: ALL, minimumAge: 16 Years, maximumAge: 25 Years, stdAges: CHILD, stdAges: ADULT, contactsLocationsModule locations facility: Riphah international University, city: Islamabad, state: ICT, zip: 44000, country: Pakistan, geoPoint lat: 33.72148, lon: 73.04329, hasResults: False |
protocolSection identificationModule nctId: NCT06292442, orgStudyIdInfo id: REC/RCR&AHS/23/0237, briefTitle: Effects of HIIT on Muscle Strength, Atrophy and Aerobic Capacity in Stroke Patients., statusModule overallStatus: COMPLETED, startDateStruct date: 2023-09-01, primaryCompletionDateStruct date: 2023-10-01, completionDateStruct date: 2023-11-01, studyFirstPostDateStruct date: 2024-03-05, lastUpdatePostDateStruct date: 2024-03-05, sponsorCollaboratorsModule leadSponsor name: Riphah International University, class: OTHER, descriptionModule briefSummary: To determine the effects of High-Intensity Interval Training on muscle strength, atrophy, and aerobic capacity in stroke patients., conditionsModule conditions: Stroke, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: DOUBLE, whoMasked: PARTICIPANT, whoMasked: INVESTIGATOR, enrollmentInfo count: 34, type: ACTUAL, armsInterventionsModule interventions name: traditional physical therapy, interventions name: High intensity interval training, outcomesModule primaryOutcomes measure: Muscle strength, primaryOutcomes measure: Muscle Atrophy, primaryOutcomes measure: 6-Minute Walk Test (6MWT), primaryOutcomes measure: Aerobic Capacity, secondaryOutcomes measure: Fastest Gait Speed, eligibilityModule sex: ALL, minimumAge: 40 Years, maximumAge: 60 Years, stdAges: ADULT, contactsLocationsModule locations facility: Jinnah Hospital, Lahore, city: Lahore, state: Punjab, zip: 54000, country: Pakistan, geoPoint lat: 31.558, lon: 74.35071, hasResults: False |
protocolSection identificationModule nctId: NCT06292429, orgStudyIdInfo id: REC/RCR & AHS/23/1104, briefTitle: Effects of Complex Training in Cricket Fast Bowlers, statusModule overallStatus: RECRUITING, startDateStruct date: 2023-06-16, primaryCompletionDateStruct date: 2024-06, completionDateStruct date: 2024-06, studyFirstPostDateStruct date: 2024-03-05, lastUpdatePostDateStruct date: 2024-03-05, sponsorCollaboratorsModule leadSponsor name: Riphah International University, class: OTHER, descriptionModule briefSummary: This study will be a randomized controlled trial and the data will be collected from National Cricket Academy and domestic cricket clubs. The sample size will be calculated by conducting a pilot study. There will be three groups. Group-A will be receiving Complex training, Group-B will be receiving Conventional training and Group C as a Control Group. Athletes with same physical fitness level will be recruited. There will be parallel assignment of the participants. Assessor will be kept blinded. All the parameters would be assessed at Baseline, 6 Weeks, 12 Weeks. Physical fitness will be assessed through Field Testing. Bowling performance will be assessed through speed machine and Kinovea Software. Work capacity will be assessed through step testing. Muscle strength will be assessed through Dynamometer. Lastly, BMD will be assessed though Bone Densitometer., conditionsModule conditions: Resistance Training, conditions: Plyometric Exercise, conditions: Sports Physical Therapy, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: randomized controlled trial, primaryPurpose: OTHER, maskingInfo masking: SINGLE, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 40, type: ESTIMATED, armsInterventionsModule interventions name: Complex Training, interventions name: Conventional Training, interventions name: Control Group, outcomesModule primaryOutcomes measure: Physical fitness (linear speed capability), primaryOutcomes measure: Physical fitness (lower limb explosive power), primaryOutcomes measure: Physical fitness (upper body strength test), primaryOutcomes measure: Physical fitness (lower body strength test), primaryOutcomes measure: Physical fitness (upper body muscular endurance), primaryOutcomes measure: Physical fitness (aerobic capacity), primaryOutcomes measure: Bowling performance (Ball speed), primaryOutcomes measure: Bowling performance (run-up time), primaryOutcomes measure: Bowling performance (accuracy), primaryOutcomes measure: Bowling performance (RPE), secondaryOutcomes measure: Work capacity, secondaryOutcomes measure: Muscle Strength, secondaryOutcomes measure: Bone Density, eligibilityModule sex: MALE, minimumAge: 18 Years, maximumAge: 25 Years, stdAges: ADULT, contactsLocationsModule locations facility: Pakistan Sports Board Coaching Center, status: RECRUITING, city: Lahore, state: Punjab, zip: 54000, country: Pakistan, contacts name: Nasrullah Rana, role: CONTACT, phone: +92 334 5492964, contacts name: Muhammad Atif Javed, PP-DPT, role: PRINCIPAL_INVESTIGATOR, contacts name: Syed Asadullah Arslan, Ph.D., role: SUB_INVESTIGATOR, geoPoint lat: 31.558, lon: 74.35071, hasResults: False |
protocolSection identificationModule nctId: NCT06292416, orgStudyIdInfo id: REC/0257Huma Saleem, briefTitle: Mirror Therapy With Sensory Motor Training in Children With CP, statusModule overallStatus: RECRUITING, startDateStruct date: 2023-12-30, primaryCompletionDateStruct date: 2024-05-14, completionDateStruct date: 2024-05-14, studyFirstPostDateStruct date: 2024-03-05, lastUpdatePostDateStruct date: 2024-03-05, sponsorCollaboratorsModule leadSponsor name: Riphah International University, class: OTHER, descriptionModule briefSummary: The study compares two interventions in CP children: mirror therapy with sensory motor training versus mirror therapy with motor training. Mirror therapy works by manipulating the brain out of pain, ultimately improving movement in patients with one-sided paralysis. It can be used in combination with other therapies to assist patients with cerebral palsy in retraining the brains, restoring function, and enhancing the overall quality of life. The purpose of this study is to use a combination of Mirror therapy with sensory motor training and motor training and observe which one of these combinations has the most desirable effects in improving movement and quality of life in CP Children, conditionsModule conditions: Cerebral Palsy, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: Assignment, primaryPurpose: TREATMENT, maskingInfo masking: DOUBLE, maskingDescription: participants and outcome assessors will be kept blind about the intervention which the patients will be receiving., whoMasked: PARTICIPANT, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 54, type: ESTIMATED, armsInterventionsModule interventions name: Experimental: Mirror therapy with sensory motor training., interventions name: Experimental: Mirror Therapy with motor training, interventions name: Experimental: Motor Training, outcomesModule primaryOutcomes measure: The Melbourne Assessment of Unilateral Upper Limb Function (Melbourne Assessment), primaryOutcomes measure: Jebsen Taylor Hand dysfunction test, eligibilityModule sex: ALL, minimumAge: 6 Years, maximumAge: 12 Years, stdAges: CHILD, contactsLocationsModule locations facility: Eliya care Centre Faisalabad, status: RECRUITING, city: Lahore, state: Punjab, country: Pakistan, contacts name: Ammara Abbas, tDPT, role: CONTACT, phone: 03214932464, email: [email protected], contacts name: Huma Saleem, MS NMPT*, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 31.558, lon: 74.35071, hasResults: False |
protocolSection identificationModule nctId: NCT06292403, orgStudyIdInfo id: Farwa Akhtar, briefTitle: Effects of Strength Training of Non-paretic Upper and Lower Limb With or Without Mirror Therapy, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-03-10, primaryCompletionDateStruct date: 2024-12-30, completionDateStruct date: 2025-01-01, studyFirstPostDateStruct date: 2024-03-05, lastUpdatePostDateStruct date: 2024-03-05, sponsorCollaboratorsModule leadSponsor name: Riphah International University, class: OTHER, descriptionModule briefSummary: The aim of this study is to find the effects of strength training with or without mirror therapy of non-paralytic upper limb for functional activities and in lower limb for gait pattern, balance and stability, and ADLs of paralytic side in patients with acute and sub-acute stroke. A randomized controlled trial that will include total 44 participants .The control group will undergo usual rehabilitation training along with strength training. The trial group will undergo strength training and mirror therapy of NHS on the basis of usual rehabilitation training. For the control group, training time will be 30 minutes, once a day, 3 days a week for 8 weeks. IN trial group, training time will be 30 minutes therapy, once a day, 3 days a week for 8 weeks. were allowed to rest for 3-5 min during each training. Data collected will be analyzed through SPSS 25., conditionsModule conditions: Stroke, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: 2 groups1. Strength training only group2. strength training and mirror therapy group, primaryPurpose: TREATMENT, maskingInfo masking: DOUBLE, whoMasked: PARTICIPANT, whoMasked: INVESTIGATOR, enrollmentInfo count: 44, type: ESTIMATED, armsInterventionsModule interventions name: Strength Training, interventions name: Mirror therapy, outcomesModule primaryOutcomes measure: Modified Barthel Index, primaryOutcomes measure: Dynamic Gait Index, primaryOutcomes measure: Berg Balance Scale, eligibilityModule sex: FEMALE, minimumAge: 18 Years, maximumAge: 24 Years, stdAges: ADULT, contactsLocationsModule locations facility: Fatima Hospital, city: Rawalpindi, state: Punjab, country: Pakistan, contacts name: Sara Aabroo, NMPT, role: CONTACT, phone: 03155185508, email: [email protected], contacts name: Farwa Akhtar, NMPT, role: CONTACT, geoPoint lat: 33.6007, lon: 73.0679, hasResults: False |
protocolSection identificationModule nctId: NCT06292390, orgStudyIdInfo id: AIBU-SBF-CY-09, briefTitle: The Effect Of Pet Therapy Applıed To Elders's Sleep And Qualıty Of Lıfe, statusModule overallStatus: COMPLETED, startDateStruct date: 2021-11-15, primaryCompletionDateStruct date: 2022-05-12, completionDateStruct date: 2023-06-22, studyFirstPostDateStruct date: 2024-03-05, lastUpdatePostDateStruct date: 2024-03-15, sponsorCollaboratorsModule leadSponsor name: Tokat Gaziosmanpasa University, class: OTHER, descriptionModule briefSummary: Quality of life is defined as functional abilities that include the ability to fulfill an individual social role, the degree and quality of social interaction, mental health, physical competence, somatic senses such as pain, and satisfaction with life. The World Health Organization (WHO) defined quality of life in 1947 as a decrease not only in disease, disorder or disability, but also in physical, mental and social well-being. Old age is one of the situations in which the quality of life decreases. It is reported that the poor social and financial situation of individuals, low educational level, gender, lack of physical movement, decreased daily life activity level, decreased mobility ability, fall anxiety, sleep problems and other conditions that cause disability are determinants of the quality of life. According to the results of Bloom et al.'s study, elderly people wake up at night due to health problems.According to the literature, the sleep and life of pet therapy applied to elderly individuals living in a nursing home there have not been any studies examining the effect on quality. For this reason, it was aimed to conduct this study in order to determine the effect of pet therapy applied to elderly individuals living in a nursing home on sleep and quality of life.The study was planned to be conducted in a randomized controlled manner in order to determine the effect of pet therapy applied for one hour twice a week for 6 weeks to elderly people living in a nursing home in Tokat province on sleep pattern and quality of life. In the study, gender, age group and the presence of chronic diseases were taken as equivalence criteria. Since conducting the study single-blind will increase the reliability of the study, the application of the scales was applied by another researcher/surveyor other than the main researcher., conditionsModule conditions: Pet Therapy Effect of Sleep and Quality of Life, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: Randomized controlled trial (Two groups with intervention and control group), primaryPurpose: SUPPORTIVE_CARE, maskingInfo masking: DOUBLE, maskingDescription: A pollster who did not know the people in the control and intervention group was selected and collected the data. The SPSS data were entered by someone selected other than the surveyor and the researcher. Thus, the study was conducted as a double-blind., whoMasked: INVESTIGATOR, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 59, type: ACTUAL, armsInterventionsModule interventions name: Pet Therapy, outcomesModule primaryOutcomes measure: PUKI, secondaryOutcomes measure: CASP-19 QUALITY OF LIFE, eligibilityModule sex: ALL, minimumAge: 55 Years, maximumAge: 75 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Nursing Home, city: Tokat, state: Center, zip: 60000, country: Turkey, geoPoint lat: 40.31389, lon: 36.55444, hasResults: False |
protocolSection identificationModule nctId: NCT06292377, orgStudyIdInfo id: BRUFAST, briefTitle: Better Understanding of Fatigue After STroke, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-03-01, primaryCompletionDateStruct date: 2026-03-01, completionDateStruct date: 2026-03-01, studyFirstPostDateStruct date: 2024-03-05, lastUpdatePostDateStruct date: 2024-03-05, sponsorCollaboratorsModule leadSponsor name: Brugmann University Hospital, class: OTHER, descriptionModule briefSummary: Stroke is worldwide the second most common cause of death following heart attack and the leading cause of disability. Post-stroke fatigue (PSF) is a common complication after stroke and can be defined as 'an overwhelming exhaustion or tiredness, not related to exertion, which does not typically improve with rest'. Fatigue following stroke can be divided into early (\< 3 months) and late (\> 3 months) fatigue. PSF can have a considerable impact on a person's everyday activities and quality of life, participation in the rehabilitation process and levels of caregiver burden. Yet no efficient treatment exists to prevent or cure PSF because the pathophysiology remains unclear and seems to be multifaceted.Autonomic dysfunction is a common complication after stroke, associated with higher morbidity and mortality. An easy tool to measure the function of the autonomic nervous system (ANS) is heart rate variability (HRV), which is defined as the beat-to-beat variation of the heart rate (= interbeat interval (IBI)). It is the result of alterations in the sympathetic and parasympathetic nervous system. In recent systematic reviews, authors stipulate that HRV can be regarded as a prognostic factor for short- and long-term stroke outcomes. HRV can be derived from 24 hours, 5 minutes (short-term) and \< 5 minutes (ultra-short-term) measurements by applying time-domain and frequency-domain indices.Autonomic dysfunction has been related to chronic fatigue syndrome, in addition to fatigue in multiple sclerosis, Parkinson's disease and myasthenia gravis. However, to the best of our knowledge, the relationship between autonomic dysfunction and PSF has not yet been fully investigated.Fatigue is also common in cardiovascular diseases, especially in patients with heart failure (HF). HF can contribute to fatigue after stroke, independently of stroke.Cardiac complications after acute ischemic stroke (AIS), such as arrhythmias, cardiac dysfunction and myocardial injury, are frequent. The so-called 'stroke-heart syndrome', a concept introduced in 2018, describes a broad spectrum of cardiac changes observed in 10-20% of patients with AIS within the first month after stroke onset, with a peak in the first 72 hours. A dysregulation in the neural-cardiac control after stroke is suspected to be the cause of the cascade leading to cardiac complications, in which autonomic dysfunction and inflammation seem to be part of the underlying mechanism.Based on previous studies and by analogy with other neurological diseases, the investigators hypothesize that autonomic dysfunction following AIS contributes to PSF and that patients presenting heart failure as a complication following AIS have an increased risk of PSF.To confirm this hypothesis, the investigators will conduct a prospective, interventional study where patients who are hospitalized at the Stroke Unit, within 72 hours after stroke symptom onset, will be included. Evaluation will take place of (a) the relationship between autonomic dysfunction (HRV) and early and late PSF, and of (b) the relationship between cardiac dysfunction and early PSF and late PSF.There will also be an investigation into following elements:* the association between early and late PSF and (a) certain inflammatory markers at admission (CRP, NLR), (b) stroke localization and (c) baseline imaging markers of brain frailty.* the role of pre-existing fatigue + pre-existing or post-stroke newly diagnosed cognitive impairment, depression and sleep disturbances on the course of PSF., conditionsModule conditions: Stroke, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NA, interventionModel: SINGLE_GROUP, primaryPurpose: BASIC_SCIENCE, maskingInfo masking: NONE, enrollmentInfo count: 250, type: ESTIMATED, armsInterventionsModule interventions name: ECG, interventions name: Transthoracic echography (TTE), interventions name: Blood sampling, outcomesModule primaryOutcomes measure: Heart rate variability (HRV), primaryOutcomes measure: Heart rate variability (HRV), primaryOutcomes measure: Heart rate variability (HRV), primaryOutcomes measure: Transthoracic echography (TTE), primaryOutcomes measure: Transthoracic echography (TTE), primaryOutcomes measure: Transthoracic echography (TTE), primaryOutcomes measure: Fatigue Severity Scale, primaryOutcomes measure: Fatigue Severity Scale, primaryOutcomes measure: Fatigue Severity Scale, primaryOutcomes measure: N-terminal pro-brain natriuretic peptide (NT-proBNP), primaryOutcomes measure: N-terminal pro-brain natriuretic peptide (NT-proBNP), primaryOutcomes measure: N-terminal pro-brain natriuretic peptide (NT-proBNP), primaryOutcomes measure: cardiac troponin (cTnT), secondaryOutcomes measure: Blood CRP level, secondaryOutcomes measure: Blood neutrophil-to-lymphocyte ratio (NLR), secondaryOutcomes measure: Stroke localization in the brain, secondaryOutcomes measure: Fazekas scale, secondaryOutcomes measure: Global cortical atrophy scale, secondaryOutcomes measure: Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE), secondaryOutcomes measure: Presence for pre-existing fatigue (yes/no), secondaryOutcomes measure: Duration of pre-existing fatigue, secondaryOutcomes measure: Patient Health Questionnaire-2 (PHQ-2), secondaryOutcomes measure: Patient Health Questionnaire-2 (PHQ-2), secondaryOutcomes measure: Patient Health Questionnaire-2 (PHQ-2), secondaryOutcomes measure: Montreal Cognitive Assessment (MoCA) questionnaire, secondaryOutcomes measure: Montreal Cognitive Assessment (MoCA) score, secondaryOutcomes measure: Insomnia Severity Index (ISI), secondaryOutcomes measure: Insomnia Severity Index (ISI), secondaryOutcomes measure: Insomnia Severity Index (ISI), secondaryOutcomes measure: Complete blood count abnormalities: yes/no, secondaryOutcomes measure: Renal insufficiency: yes/no, secondaryOutcomes measure: Electrolyte imbalance: yes/no, secondaryOutcomes measure: Abnormal liver enzymes: yes/no, secondaryOutcomes measure: Dyslipidemia: yes/no, secondaryOutcomes measure: Diabetes: yes/no, secondaryOutcomes measure: Thyroid disorder: yes/no, secondaryOutcomes measure: Iron deficiency: yes/no, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: CHU Brugmann, city: Brussels, zip: 1020, country: Belgium, contacts name: Anissa OURTANI, MD, role: CONTACT, phone: 024754819, email: [email protected], contacts name: Anissa OURTANI, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 50.85045, lon: 4.34878, locations facility: UZ Brussel, city: Brussel, zip: 1090, country: Belgium, contacts name: Sylvie De Raedt, MD, role: CONTACT, email: [email protected], contacts name: Sylvie De Raedt, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 50.85045, lon: 4.34878, hasResults: False |
protocolSection identificationModule nctId: NCT06292364, orgStudyIdInfo id: PGIDS/BHRC/23/106, briefTitle: Comparison of Retention Characteristics of Immediate vs Delayed Retainer Delivery Using 3D Digital Model Analysis, statusModule overallStatus: RECRUITING, startDateStruct date: 2023-11-05, primaryCompletionDateStruct date: 2024-11-05, completionDateStruct date: 2024-12-05, studyFirstPostDateStruct date: 2024-03-05, lastUpdatePostDateStruct date: 2024-03-05, sponsorCollaboratorsModule leadSponsor name: Postgraduate Institute of Dental Sciences Rohtak, class: OTHER, descriptionModule briefSummary: Retention has been defined as "the holding of teeth following orthodontic treatment in the treated position for the period of time necessary for the maintenance of the result". Controversies regarding retention regime exist due to lack of high quality evidence regarding duration, type and timing of different type retainer.The present randomised controlled trial will be undertaken to assess the changes and compare if there is any difference in movement of teeth in post orthodontic treatment cases with immediate and delayed (post 7 days) delivery using beggs retainer and change in level of bone biomarker over 6 months period of retention ., conditionsModule conditions: Relapse, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NON_RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: PREVENTION, maskingInfo masking: SINGLE, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 40, type: ESTIMATED, armsInterventionsModule interventions name: immediate orthodontic retainer delivery, interventions name: delayed orthodontic retainer delivery, outcomesModule primaryOutcomes measure: overjet, primaryOutcomes measure: overjet, primaryOutcomes measure: overjet, primaryOutcomes measure: Overjet, primaryOutcomes measure: contact point displacement, primaryOutcomes measure: contact point displacement, primaryOutcomes measure: contact point displacement, primaryOutcomes measure: contact point displacement, primaryOutcomes measure: overbite, primaryOutcomes measure: overbite, primaryOutcomes measure: overbite, primaryOutcomes measure: overbite, primaryOutcomes measure: intermolar width, primaryOutcomes measure: intermolar width, primaryOutcomes measure: intermolar width, primaryOutcomes measure: intermolar width, primaryOutcomes measure: intercanine width, primaryOutcomes measure: intercanine width, primaryOutcomes measure: intercanine width, primaryOutcomes measure: intercanine width, secondaryOutcomes measure: GCF - elisa, secondaryOutcomes measure: GCF - elisa, secondaryOutcomes measure: GCF - elisa, secondaryOutcomes measure: GCF - elisa, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 45 Years, stdAges: ADULT, contactsLocationsModule locations facility: Pgids Rohtak, status: RECRUITING, city: Rohtak, state: Haryana, zip: 124001, country: India, contacts name: Dr. Rekha Sharma, MDS, role: CONTACT, phone: 8076190296, email: [email protected], geoPoint lat: 28.89447, lon: 76.58917, hasResults: False |
protocolSection identificationModule nctId: NCT06292351, orgStudyIdInfo id: DMBN_ALZH-2022-II, briefTitle: DMB-I in the Treatment of Alzheimer Type Dementia, statusModule overallStatus: RECRUITING, startDateStruct date: 2023-12-27, primaryCompletionDateStruct date: 2024-12-21, completionDateStruct date: 2024-12-21, studyFirstPostDateStruct date: 2024-03-05, lastUpdatePostDateStruct date: 2024-03-20, sponsorCollaboratorsModule leadSponsor name: Bigespas LTD, class: INDUSTRY, descriptionModule briefSummary: The purpose of this study is to assess the efficacy and safety of DMB-I for the treatment of patients with Alzheimer type dementia., conditionsModule conditions: Alzheimer Disease, conditions: Dementia of Alzheimer Type, designModule studyType: INTERVENTIONAL, phases: PHASE2, phases: PHASE3, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: DOUBLE, whoMasked: PARTICIPANT, whoMasked: INVESTIGATOR, enrollmentInfo count: 135, type: ESTIMATED, armsInterventionsModule interventions name: DMB-I (Dimebon), interventions name: Placebo, outcomesModule primaryOutcomes measure: Mean change in Alzheimer's Disease Assessment Scale score after 26 weeks of therapy (Visit 6) compared to baseline (Visit 0) in patients receiving the study drug or placebo, secondaryOutcomes measure: Mean change in cognitive impairment score on the Alzheimer's Disease Assessment Scale after 12 weeks of therapy compared to baseline, secondaryOutcomes measure: Mean change in Mini-Mental State Examination score after 12 weeks of therapy (Visit 4) and after 26 weeks of therapy (Visit 6) compared to baseline (Visit 0), secondaryOutcomes measure: Change in the quality of life of patients according to the Quality of Life - Alzheimer's Disease questionnaire after 12 weeks of therapy (Visit 4) and after 26 weeks of therapy (Visit 6) compared to baseline (Visit 1), secondaryOutcomes measure: Change in the general clinical impression in accordance with the Clinical Global Impressions Scale after 12 weeks of therapy (Visit 4) and after 26 weeks of therapy (Visit 6) compared to baseline (Visit 1), secondaryOutcomes measure: Dynamics on the Lawton's Instrumental activities of daily living scale after 12 weeks of therapy (Visit 4) and after 26 weeks of therapy (Visit 6) compared to baseline (Visit 1), eligibilityModule sex: ALL, minimumAge: 60 Years, maximumAge: 90 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: State autonomous healthcare institution "Transregional Clinical Diagnostic Center", status: RECRUITING, city: Kazan, zip: 420101, country: Russian Federation, contacts name: Dina Khasanova, role: CONTACT, email: [email protected], geoPoint lat: 55.78874, lon: 49.12214, locations facility: Federal State Budgetary Institution "Federal center for brain and neurotechnologies" of the Federal Medical and Biological Agency (FSBI "FCBN" of Russia's FMBA), status: RECRUITING, city: Moscow, zip: 117997, country: Russian Federation, contacts name: Anna N. Bogolepova, role: CONTACT, email: [email protected], geoPoint lat: 55.75222, lon: 37.61556, locations facility: Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), status: RECRUITING, city: Moscow, zip: 119991, country: Russian Federation, contacts name: Marina A. Kinkulkina, role: CONTACT, email: [email protected], geoPoint lat: 55.75222, lon: 37.61556, locations facility: State public healthcare institution Leningrad regional psychoneurologic dispensary, status: RECRUITING, city: Roshchino, zip: 188820, country: Russian Federation, contacts name: Natalia A. Penchul, role: CONTACT, email: [email protected], geoPoint lat: 60.25191, lon: 29.6085, locations facility: "Medical Center Nova Vita", status: RECRUITING, city: Rostov-on-Don, zip: 344082, country: Russian Federation, contacts name: Dhaval Mavani, role: CONTACT, email: [email protected], geoPoint lat: 47.23135, lon: 39.72328, locations facility: Saint Petersburg State budgetary healthcare institution "City Hospital № 40 of Kurortniy district", status: RECRUITING, city: Saint Petersburg, zip: 197706, country: Russian Federation, contacts name: Alina S Agaf'yina, role: CONTACT, email: [email protected], geoPoint lat: 59.93863, lon: 30.31413, locations facility: "Centre of evidence-based medicine" LLC, status: RECRUITING, city: Yaroslavl, zip: 150000, country: Russian Federation, contacts name: Stanislav O. Pozdnyakov, role: CONTACT, email: [email protected], geoPoint lat: 57.62987, lon: 39.87368, hasResults: False |
protocolSection identificationModule nctId: NCT06292338, orgStudyIdInfo id: AUCHAU, briefTitle: Lung Sonar in Neonatal Respiratory Disorders, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-05-01, primaryCompletionDateStruct date: 2025-05-01, completionDateStruct date: 2025-05-01, studyFirstPostDateStruct date: 2024-03-05, lastUpdatePostDateStruct date: 2024-03-05, sponsorCollaboratorsModule leadSponsor name: Gehad Adel Mohammed Hussein, class: OTHER, descriptionModule briefSummary: This study aimed to determine the value of chest ultrasonography in comparison to other tools as chest x-ray and ABG in diagnosis and follow up of neonates with respiratory disorders., conditionsModule conditions: Neonatal Respiratory Distress, designModule studyType: OBSERVATIONAL, designInfo observationalModel: OTHER, timePerspective: CROSS_SECTIONAL, enrollmentInfo count: 1, type: ESTIMATED, outcomesModule primaryOutcomes measure: Comparing between LUS and Chest xRay in neonatal respiratory disorders assessment, eligibilityModule sex: ALL, minimumAge: 1 Day, maximumAge: 28 Days, stdAges: CHILD, hasResults: False |
protocolSection identificationModule nctId: NCT06292325, orgStudyIdInfo id: FDG_88-17, briefTitle: Psychological Aspects in OSA, acronym: PSICOSA, statusModule overallStatus: ENROLLING_BY_INVITATION, startDateStruct date: 2023-05-08, primaryCompletionDateStruct date: 2023-05-08, completionDateStruct date: 2024-05-31, studyFirstPostDateStruct date: 2024-03-05, lastUpdatePostDateStruct date: 2024-03-07, sponsorCollaboratorsModule leadSponsor name: Fondazione Don Carlo Gnocchi Onlus, class: OTHER, collaborators name: Catholic University of the Sacred Heart, descriptionModule briefSummary: The research project consists of an observational study. Obstructive Sleep Apnea (OSA) is a condition characterized by recurrent episodes of upper airway collapse during sleep, leading to decreased blood oxygen levels and disruptions of normal sleep patterns. Estimates of its prevalence vary, but its impact on patients' quality of life is evident.The research aims to explore the perception and awareness of the disease and its impact on the individual and couple's lives of patients with OSA and their bed partners, to assess patients' perceptions of the disease and symptoms, as well as their bed partners' perceptions. Moreover, psychological aspects of living with OSA, such as perceived stress, depression, anxiety, sleep quality, daily sleepiness will be studied to observe the association with Continuous Positive Airway Pressure (CPAP) adherence., conditionsModule conditions: Osa Syndrome, designModule studyType: OBSERVATIONAL, designInfo observationalModel: CASE_ONLY, timePerspective: CROSS_SECTIONAL, enrollmentInfo count: 246, type: ESTIMATED, armsInterventionsModule interventions name: Continuous Positive Airway Pressure (CPAP), outcomesModule primaryOutcomes measure: Brief Illness Perception Questionnaire (Brief IPQ), primaryOutcomes measure: CPAP therapy adherence (hours/night), primaryOutcomes measure: Dyadic Adjustment Scale (DAS), secondaryOutcomes measure: The experience in close relationships-revised (ECR-R) Scale, secondaryOutcomes measure: The Psychological General Well-Being Index (PGWB-S), secondaryOutcomes measure: The Patient Health Questionnaire - 9 (PHQ-9), secondaryOutcomes measure: The Generalized Anxiety Scale -7 (GAD-7), secondaryOutcomes measure: The Mannheim Dream Questionnaire (MADRE), secondaryOutcomes measure: The EP worth scale (ESS), secondaryOutcomes measure: Pittsburgh Sleep Quality Index (PSQI), eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: IRCCS Fondazione Don Carlo Gnocchi, city: Milan, state: MI, zip: 20148, country: Italy, geoPoint lat: 45.46427, lon: 9.18951, hasResults: False |
protocolSection identificationModule nctId: NCT06292312, orgStudyIdInfo id: 19.12.2023/10-483, briefTitle: Investigation of the Effectiveness of Craniosacral Therapy in Patients With Multiple Sclerosis., statusModule overallStatus: RECRUITING, startDateStruct date: 2024-02-27, primaryCompletionDateStruct date: 2025-04-15, completionDateStruct date: 2025-05-15, studyFirstPostDateStruct date: 2024-03-05, lastUpdatePostDateStruct date: 2024-03-05, sponsorCollaboratorsModule leadSponsor name: Ankara Yildirim Beyazıt University, class: OTHER, collaborators name: Lokman Hekim Üniversitesi, descriptionModule briefSummary: Although the cause of Multiple Sclerosis (MS), one of the common demyelinating diseases of the central nervous system, has not yet been fully elucidated, autonomic nervous system dysfunction has been suggested in its etiology. Symptoms such as fatigue, problems with bladder, bowel, cardiovascular, sleep, sexual and sweating functions, abnormal sympathetic skin response or decreased heart rate variation support this hypothesis.In the treatment of many neurological diseases such as Multiple Sclerosis, complementary medicine practices and non-traditional therapies have recently been shown to be effective in addition to conventional practices. One of these practices, craniosacral therapy (CST), uses manual palpation and manipulation of the craniosacral system to influence sensory, motor, cognitive and emotional processes in the nervous system. In addition, it is thought that applying external force to certain bone elements can have a positive effect on various symptoms in patients with MS, based on the knowledge that it can be transmitted within the system., conditionsModule conditions: Multiple Sclerosis, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: dual parallel group design, primaryPurpose: TREATMENT, maskingInfo masking: SINGLE, maskingDescription: Single (outcomes assesor) The evaluation of the patients will be carried out by a blinded investigator., whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 32, type: ESTIMATED, armsInterventionsModule interventions name: Craniosacral therapy, interventions name: Conventional physiotherapy, outcomesModule primaryOutcomes measure: Dynamic posturography, primaryOutcomes measure: Heart rate variability, secondaryOutcomes measure: Pain level, secondaryOutcomes measure: Central sensitization, secondaryOutcomes measure: Fatigue, secondaryOutcomes measure: Sleep quality, secondaryOutcomes measure: Life quality, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 65 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Ankara Yıldırım Beyazıt University, status: RECRUITING, city: Ankara, zip: 06010, country: Turkey, contacts name: Hilal Aslan, role: CONTACT, phone: 05372565397, email: [email protected], geoPoint lat: 39.91987, lon: 32.85427, hasResults: False |
protocolSection identificationModule nctId: NCT06292299, orgStudyIdInfo id: INGN22RM471P, secondaryIdInfos id: 10072600, type: OTHER_GRANT, domain: PneumoWave Ltd & Innovate UK, briefTitle: The PARS Study: Paediatric Advanced Respiratory Service Study - An Observational Diagnostic Feasibility Study, acronym: PARS, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-03-01, primaryCompletionDateStruct date: 2025-12, completionDateStruct date: 2025-12, studyFirstPostDateStruct date: 2024-03-05, lastUpdatePostDateStruct date: 2024-03-05, sponsorCollaboratorsModule leadSponsor name: NHS Greater Clyde and Glasgow, class: OTHER, collaborators name: INNOVATEUK, descriptionModule briefSummary: Diagnostic investigations in paediatric respiratory and sleep medicine are often challenging due to patient size (due to prematurity), tolerability, and compliance with "gold standard equipment". Children with sensory/behavioural issues, at increased risk of sleep disordered breathing (SDB), often find tolerating standard diagnostic equipment difficult. There is a need to develop non-invasive, wireless, devices designed for the paediatric population. Devices must address health in-equalities as high-risk children, with low birth weights, genetic syndromes, or complex neuro-disabilities, are often unable to undergo current investigations, particularly in sleep medicine. Prompt and accurate diagnosis of SDB is important to facilitate early intervention and improve outcomesInfants in the neonatal period can have immature breathing control which manifests as excessive central breathing pauses, apnoea's, whilst asleep requiring oxygen therapy. There is also a risk to newborn term infants of sudden unexpected neonatal collapse, even in "low risk" babies. Diagnosis of breathing issues in babies can be challenging since babies are often too small for standard monitoring equipment. Effective monitoring and appropriate treatment of apnoea's has been shown to improve prognosis in terms of 5-year mortality and neurodevelopmental outcomes.This observational study is part of a phased clinical program of research that aims to validate a small wearable biosensor developed by PneumoWave Ltd in a paediatric clinical setting with the overall primary endpoints of monitoring and assessing respiratory pattern as an aid to sleep diagnostics, and as a device to monitor apnoea in neonatal patients., conditionsModule conditions: Sleep Disordered Breathing, conditions: Apnea of Prematurity, conditions: Respiratory Rate, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 150, type: ESTIMATED, armsInterventionsModule interventions name: Pneumowave, outcomesModule primaryOutcomes measure: Assess the feasibility of collecting respiratory waveform data using Pneumowave device in patients who have (1) attended the sleep laboratory for CR- polysomnography and (2) are inpatient in neonatal unit, secondaryOutcomes measure: Collate respiratory data in patients who have attended the sleep laboratory for CR- poly or inpatient in neonatal unit. Respiratory data will observe: (1) Normal respiratory effort (2) Response to treatments, secondaryOutcomes measure: Collate waveform and motion artefact data in patients who have attended overnight CR-polysomnography, secondaryOutcomes measure: Collate waveform and motion artefact data in neonatal patients at risk of central apnoea, secondaryOutcomes measure: Assess the useability of Pneumowave in the opinion of the clinician, nurse and patient, eligibilityModule sex: ALL, minimumAge: 1 Minute, maximumAge: 16 Years, stdAges: CHILD, contactsLocationsModule locations facility: Royal Hospital for Children, Glasgow, city: Glasgow, state: Glasgow City, zip: G51 4TF, country: United Kingdom, contacts name: Ross J Langley, MBChB BSc PhD MRCPCH, role: CONTACT, phone: 0141 451 6582, email: [email protected], contacts name: Hannah Vennard, MBChB BMSc, role: CONTACT, phone: 0141 451 6582, email: [email protected], geoPoint lat: 55.86515, lon: -4.25763, locations facility: Royal Hospital for Children, Glasgow, city: Glasgow, zip: G51 4TF, country: United Kingdom, geoPoint lat: 55.86515, lon: -4.25763, hasResults: False |
protocolSection identificationModule nctId: NCT06292286, orgStudyIdInfo id: UW 22-704, briefTitle: Secondary Interval Cytoreductive Surgery in Platinum-sensitive Recurrent Epithelial Ovarian Cancer, acronym: SCENIC, statusModule overallStatus: RECRUITING, startDateStruct date: 2023-11-01, primaryCompletionDateStruct date: 2025-12-31, completionDateStruct date: 2026-07-01, studyFirstPostDateStruct date: 2024-03-05, lastUpdatePostDateStruct date: 2024-03-05, sponsorCollaboratorsModule leadSponsor name: The University of Hong Kong, class: OTHER, descriptionModule briefSummary: About 80% of advanced ovarian cancer patients recurred in 2-3 years. Secondary cytoreduction benefits selected patients who have high chance of complete resection. Whether secondary interval surgery can be used at recurrence is not known., conditionsModule conditions: Recurrent Ovarian Carcinoma, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NA, interventionModel: SINGLE_GROUP, interventionModelDescription: Neoadjuvant carboplatin and paclitaxel followed by cytoreductive surgery, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 18, type: ESTIMATED, armsInterventionsModule interventions name: Carboplatin or cisplatin, interventions name: Paclitaxel, gemcitabine or liposomal doxorubicin with or without bevacizumab or biosimilar, interventions name: Bevacizumab or biosimilar, interventions name: Cytoreductive surgery, outcomesModule primaryOutcomes measure: Complete resection rate, secondaryOutcomes measure: 12-month progression-free survival rate, secondaryOutcomes measure: 12-month overall survival rate, secondaryOutcomes measure: Surgical complication rate, secondaryOutcomes measure: Quality of life scale, eligibilityModule sex: FEMALE, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: The University of Hong Kong, status: RECRUITING, city: Hong Kong, country: Hong Kong, contacts name: Lesley Lau, role: CONTACT, phone: 852-22554518, contacts name: Ka Yu Tse, role: CONTACT, phone: 852-22554265, email: [email protected], contacts name: Ka Yu Tse, MBBS, PhD, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 22.27832, lon: 114.17469, hasResults: False |
protocolSection identificationModule nctId: NCT06292273, orgStudyIdInfo id: ANET19, briefTitle: Bupivacaine With Dexmedetomidine Versus Bupivacaine Alone for Transversus Abdominis Plane Block in Caesarean Section, statusModule overallStatus: COMPLETED, startDateStruct date: 2023-10-10, primaryCompletionDateStruct date: 2024-02-01, completionDateStruct date: 2024-02-20, studyFirstPostDateStruct date: 2024-03-05, lastUpdatePostDateStruct date: 2024-03-05, sponsorCollaboratorsModule leadSponsor name: Menoufia University, class: OTHER, descriptionModule briefSummary: Transversus Abdominis plane (TAP) block is a regional technique for providing analgesia of the anterolateral abdominal wall. TAP block are commonly given in patients who have undergone various abdominal as well as pelvic surgeries such as caesarean section, hysterectomy, appendicectomy and various laparoscopic surgeries. this study is conducted to analyse the effect of addition of dexmedetomidine to bupivacaine in Transversus Abdominis Plane (TAP) block., conditionsModule conditions: Post Operative Pain, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: randomized, double blind case control, primaryPurpose: PREVENTION, maskingInfo masking: DOUBLE, whoMasked: INVESTIGATOR, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 60, type: ACTUAL, armsInterventionsModule interventions name: Transversus Abdominis Plane Block with bupivacain Plus dexamethasone, interventions name: Transversus Abdominis Plane Block with bupivacain, outcomesModule primaryOutcomes measure: Post operative pain, secondaryOutcomes measure: Sedation, secondaryOutcomes measure: Heart rate, secondaryOutcomes measure: Total analgesic consumption, secondaryOutcomes measure: Side effects, eligibilityModule sex: FEMALE, minimumAge: 18 Years, maximumAge: 45 Years, stdAges: ADULT, contactsLocationsModule locations facility: Faculty of Medicine Menoufia University, city: Cairo, state: Governorate, zip: 32511, country: Egypt, geoPoint lat: 30.06263, lon: 31.24967, hasResults: False |
protocolSection identificationModule nctId: NCT06292260, orgStudyIdInfo id: 2020-2054-2, briefTitle: Digital Toolkit for Skin Diseases in LMICs: Part 2, acronym: MIND-the-SKIN2, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-03-18, primaryCompletionDateStruct date: 2026-05-31, completionDateStruct date: 2026-05-31, studyFirstPostDateStruct date: 2024-03-05, lastUpdatePostDateStruct date: 2024-04-17, sponsorCollaboratorsModule leadSponsor name: Tulane University, class: OTHER, collaborators name: Hope Commission International, collaborators name: Institut Pasteur of Cote d'Ivoire, collaborators name: Institut Raoul Follereau, collaborators name: Centre Suisse de Recherches Scientifiques en Cote d'Ivoire, collaborators name: Tokyo Medical and Dental University, descriptionModule briefSummary: Impact evaluation of eSkinHealth in improving case detection of skin NTDs and treatment outcomes in rural and urban settings, conditionsModule conditions: Skin Diseases, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NA, interventionModel: SINGLE_GROUP, primaryPurpose: DIAGNOSTIC, maskingInfo masking: NONE, enrollmentInfo count: 1000, type: ESTIMATED, armsInterventionsModule interventions name: mHealth app, outcomesModule primaryOutcomes measure: Number of cases of each skin NTD (neglected tropical disease) and other skin conditions as compared to the pre-intervention, secondaryOutcomes measure: Case confirmation rate for each skin NTD (neglected tropical disease) and other skin conditions by dermatologists, secondaryOutcomes measure: Number of days from registry to confirmatory diagnosis, secondaryOutcomes measure: Feasibility, usability, and effectiveness of the surveillance approach using eSkinHealth app, secondaryOutcomes measure: Capacity building and effectiveness of training, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Hope Commission International, status: RECRUITING, city: Abidjan, country: Côte D'Ivoire, contacts name: Aubin Yao, MS, role: CONTACT, email: [email protected], contacts name: Eric-Herman N'da Kouakou, role: CONTACT, email: [email protected], contacts name: Bamba Vagamon, MD, PhD, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 5.30966, lon: -4.01266, hasResults: False |
protocolSection identificationModule nctId: NCT06292247, orgStudyIdInfo id: A0503023, briefTitle: Effectiveness of CBT and APT on Managing Child Anxiety in Dental Office, statusModule overallStatus: ACTIVE_NOT_RECRUITING, startDateStruct date: 2023-06-01, primaryCompletionDateStruct date: 2023-10-23, completionDateStruct date: 2024-05-01, studyFirstPostDateStruct date: 2024-03-05, lastUpdatePostDateStruct date: 2024-03-07, sponsorCollaboratorsModule leadSponsor name: Mansoura University, class: OTHER, descriptionModule briefSummary: This study was conducted to the Effectiveness of Cognitive Behavioral Therapy and Auricular Plaster Therapy on Managing Child Anxiety in Dental Office., conditionsModule conditions: Dental Anxiety, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: Group 1 (CBT) Group 2 (APT) Group3 (control TSD), primaryPurpose: OTHER, maskingInfo masking: NONE, enrollmentInfo count: 60, type: ESTIMATED, armsInterventionsModule interventions name: Cognitive behavioral therapy, interventions name: Auricular plaster therapy, interventions name: Tell Show Do, outcomesModule primaryOutcomes measure: Venham Clinical Anxiety Scale, primaryOutcomes measure: Heart Rate to detect the anxiety., primaryOutcomes measure: RMS-Self Pictorial scale to detect the anxiety., secondaryOutcomes measure: Parental acceptance of the behavior management technique, eligibilityModule sex: ALL, minimumAge: 4 Years, maximumAge: 7 Years, stdAges: CHILD, contactsLocationsModule locations facility: Faculty of dentistry, city: Mansoura, state: Dakahlia, zip: 35511, country: Egypt, geoPoint lat: 31.03637, lon: 31.38069, hasResults: False |
protocolSection identificationModule nctId: NCT06292234, orgStudyIdInfo id: OMFS, briefTitle: Patient Specific Implant Versus Miniplates for Advancement of Hypoplastic Maxilla, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-05-01, primaryCompletionDateStruct date: 2025-02-01, completionDateStruct date: 2025-03-01, studyFirstPostDateStruct date: 2024-03-05, lastUpdatePostDateStruct date: 2024-04-19, sponsorCollaboratorsModule leadSponsor name: Cairo University, class: OTHER, descriptionModule briefSummary: Distraction osteogenesis is the treatment of choice in management of severe maxillary anteroposterior deficiency allowing for a progressive bone generation and simultaneous expansion of the surrounding scarred soft tissue \& better long-term stability \& less relapse rate., conditionsModule conditions: Cleft Lip and Palate, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: Parallel randomized controlled trial with 1:1 allocation ratio and superiority framework, primaryPurpose: TREATMENT, maskingInfo masking: SINGLE, maskingDescription: single blinded clinical trial, whoMasked: PARTICIPANT, enrollmentInfo count: 20, type: ESTIMATED, armsInterventionsModule interventions name: PSI, interventions name: Conventional miniplates, outcomesModule primaryOutcomes measure: Distraction effectiveness, secondaryOutcomes measure: Velopharyngeal insufficiency, secondaryOutcomes measure: Speech, secondaryOutcomes measure: Operative time, secondaryOutcomes measure: Wound dehiscence, secondaryOutcomes measure: Infection, secondaryOutcomes measure: Nerve affection, secondaryOutcomes measure: Screw loosening, secondaryOutcomes measure: Overall complications, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 30 Years, stdAges: ADULT, hasResults: False |
protocolSection identificationModule nctId: NCT06292221, orgStudyIdInfo id: H19-078, secondaryIdInfos id: R01MH119678, type: NIH, link: https://reporter.nih.gov/quickSearch/R01MH119678, briefTitle: Personalized Depression Treatment Supported by Mobile Sensor Analytics, acronym: DepWatch, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-03, primaryCompletionDateStruct date: 2025-04, completionDateStruct date: 2025-06, studyFirstPostDateStruct date: 2024-03-05, lastUpdatePostDateStruct date: 2024-03-05, sponsorCollaboratorsModule leadSponsor name: UConn Health, class: OTHER, collaborators name: National Institute of Mental Health (NIMH), descriptionModule briefSummary: The current best practice guidelines for treating depression call for close monitoring of patients, and periodically adjusting treatment as needed. This present study seeks to develop and investigate an innovative digital system, DepWatch, that leverages mobile health technologies and machine learning tools to provide clinicians objective, accurate, and timely assessment of depression symptoms to assist with their clinical decision making process. Specifically, DepWatch collects sensory data passively from smartphones and wristbands, without any user interaction, and uses simple user-friendly interfaces to collect ecological momentary assessments (EMA), medication adherence and safety related data from patients. The collected data will be fed to machine learning models to be developed in the project to provide weekly assessment of patient symptom levels and predict the trajectory of treatment response over time. The assessment and prediction results are then presented using a graphic interface to clinicians to help them make critical treatment decisions. The main question the present clinical trial aims to answer are as follows:1. Feasibility of the digital tool, DepWatch, to assist clinicians in depression treatment and inform their clinical decision process2. Effectiveness of the digital tool, DepWatch, to improve depression treatment outcomes All study participants will carry the DepWatch app on their smartphones and wear a Fitbit provided by the study team during the study period. They will also complete brief questionnaires via the app at specific time intervals throughout the study period., conditionsModule conditions: Depression, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: Two groups of participants (64 per group) will be enrolled and will participate in the study over a 3 month period . Both will receive standard of care depression treatment with their respective providers in the clinic. Both groups will undergo standard depression assessment using depression questionnaires as well as behavioral assessments using a mobile health (mHealth) tool 'DepWatch' developed by the study team in the phase I of the study. Study clinicians will receive weekly behavioral assessment reports for participants enrolled in the first 'experimental' group and will not receive such reports for the second 'control' group, primaryPurpose: DIAGNOSTIC, maskingInfo masking: NONE, maskingDescription: There is no masking, enrollmentInfo count: 128, type: ESTIMATED, armsInterventionsModule interventions name: A mobile Health (mHealth) tool called 'DepWatch', outcomesModule primaryOutcomes measure: Feasibility and Usability, secondaryOutcomes measure: Depression outcomes, eligibilityModule sex: ALL, stdAges: CHILD, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False |
protocolSection identificationModule nctId: NCT06292208, orgStudyIdInfo id: IBD0333-101, briefTitle: A Clinical Trial to Evaluate Effect of IBD0333 in Patients With Advanced Malignant Tumors, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-03-02, primaryCompletionDateStruct date: 2029-12-31, completionDateStruct date: 2030-12-31, studyFirstPostDateStruct date: 2024-03-05, lastUpdatePostDateStruct date: 2024-03-05, sponsorCollaboratorsModule leadSponsor name: SUNHO（China）BioPharmaceutical CO., Ltd., class: INDUSTRY, descriptionModule briefSummary: Primary Objectives Dose escalation phase To evaluate the safety and tolerability of IBD0333 in patients with locally advanced/metastatic solid tumor or non-Hodgkin lymphoma and to determine the maximum tolerated dose (MTD), extended recommended dose (DRDE), and/or dose limiting toxicity (DLT).Dose expansion phase To evaluate the safety and tolerability of IBD0333 in patients with locally advanced/metastatic solid tumor or non-Hodgkin lymphoma and to determine the recommended Phase 2 dose (RP2D).Clinical exploration phase To evaluate the preliminary efficacy of IBD0333 in patients with specific tumor.Secondary objectives Dose escalation phase \& Dose expansion phase To evaluate the pharmacokinetic (PK) of IBD0333 in patients with locally advanced/metastatic solid tumor or non-Hodgkin lymphoma; To evaluate the immunogenicity of IBD0333 in patients with locally advanced/metastatic solid tumor or non-Hodgkin lymphoma; To evaluate the preliminary efficacy of IBD0333 in patients with locally advanced/metastatic solid tumor or non-Hodgkin lymphoma.Clinical exploration Phase To evaluate the safety and tolerability of IBD0333 in patients with specific tumor; To evaluate the immunogenicity of IBD0333 in patients with specific tumor. Exploratory Objectives To explore biomarkers in blood and tissue that predict potential efficacy of IBD0333., conditionsModule conditions: MTD, designModule studyType: INTERVENTIONAL, phases: PHASE1, phases: PHASE2, designInfo allocation: NA, interventionModel: SINGLE_GROUP, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 48, type: ESTIMATED, armsInterventionsModule interventions name: IBD0333, outcomesModule primaryOutcomes measure: MTD, primaryOutcomes measure: DRDE, primaryOutcomes measure: Dose limiting toxicity (DLT), primaryOutcomes measure: RP2D, primaryOutcomes measure: ORR, secondaryOutcomes measure: pharmacokinetic parameters, secondaryOutcomes measure: pharmacokinetic parameters, secondaryOutcomes measure: pharmacokinetic parameters, secondaryOutcomes measure: pharmacokinetic parameters, secondaryOutcomes measure: ADA, secondaryOutcomes measure: ORR, secondaryOutcomes measure: DCR, secondaryOutcomes measure: DoR, secondaryOutcomes measure: PFS, secondaryOutcomes measure: Frequency of adverse events (AEs) and SAEs, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 80 Years, stdAges: ADULT, stdAges: OLDER_ADULT, hasResults: False |
protocolSection identificationModule nctId: NCT06292195, orgStudyIdInfo id: VitDTracking, briefTitle: Effects of Vitamin D on Health Promotion During Pregnancy and Its Impact on Prematurity-Related Outcome, acronym: VitDTracking, statusModule overallStatus: RECRUITING, startDateStruct date: 2023-11-03, primaryCompletionDateStruct date: 2024-12-31, completionDateStruct date: 2025-12-31, studyFirstPostDateStruct date: 2024-03-05, lastUpdatePostDateStruct date: 2024-03-05, sponsorCollaboratorsModule leadSponsor name: University of Évora, class: OTHER, collaborators name: Comprehensive Health Research Centre, collaborators name: Unidade Local De Saúde Do Norte Alentejano, collaborators name: Unidade local de Saúde do Baixo Alentejano, collaborators name: Unidade Local de Saúde do Alentejo Central, collaborators name: Universidade Nova de Lisboa, collaborators name: Instituto de Engenharia de Sistemas e Computadores - Inovação e Desenvolvimento de Lisboa (INESC-ID), descriptionModule briefSummary: The VitDTracking study focuses on the relevance of maternal vitamin D levels and their association with prematurity, aiming to improve maternal and child health outcomes, particularly by reducing avoidable preterm births. In Portugal, vitamin D levels during pregnancy have never been studied. Epidemiological data from other countries reveal a high prevalence of vitamin D deficiency/insufficiency, especially in pregnant women.The hypovitaminoses prevalence remains high even with a supplementation dosage of 400 to 600 IU/day during pregnancy (dosage used in Portugal), which is considered as a suboptimal dose. This phenomenon is associated with adverse maternal and child outcomes, such as intrauterine growth restriction, preeclampsia, cholestasis, hypertension, and gestational diabetes as major causes of prematurity.Additionally, the Portuguese population has a higher prevalence of genome alterations that confer a lower capacity to produce vitamin D from sunlight exposure. These genetic characteristics are present in about 19% of the population, representing a prevalence four times higher than the European average (19% versus 4.75%), leading to a higher predisposition to vitamin D deficiency., conditionsModule conditions: Vitamin D Deficiency, conditions: Pregnancy, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 1000, type: ESTIMATED, armsInterventionsModule interventions name: Exposure, outcomesModule primaryOutcomes measure: Differences in the rate of Prematurity with different maternal Vitamin D levels, primaryOutcomes measure: Differences in Birth Weight with different maternal Vitamin D levels, primaryOutcomes measure: Differences in Apgar Scores with different maternal Vitamin D levels, primaryOutcomes measure: Differences in the number of admissions to the Neonatal Intensive Care Unit with different maternal Vitamin D levels, primaryOutcomes measure: Differences in the Neonatal Morbidity rate with different maternal Vitamin D levels, primaryOutcomes measure: Differences in the Neonatal Mortality rate with different maternal Vitamin D levels, primaryOutcomes measure: Differences in the number of Neonatal Infections with different maternal Vitamin D levels, primaryOutcomes measure: Differences in the Number of Congenital Malformation diagnoses with different maternal vitamin D levels, primaryOutcomes measure: Differences in the presence of vitamin D-related polymorphisms with different maternal levels of vitamin D, secondaryOutcomes measure: Differences in maternal vitamin D levels between the three groups/cohorts related to prematurity, secondaryOutcomes measure: Differences in maternal vitamin D levels between the three groups/cohorts related to birth weight, secondaryOutcomes measure: Differences in maternal vitamin D levels between the three groups/cohorts related to Apgar scores, secondaryOutcomes measure: Differences in maternal vitamin D levels between the three groups/cohorts related to admission to the Neonatal Intensive Care Unit, secondaryOutcomes measure: Differences in maternal vitamin D levels between the three groups/cohorts related to neonatal morbidity, secondaryOutcomes measure: Differences in maternal vitamin D levels between the three groups/cohorts related to neonatal mortality, secondaryOutcomes measure: Differences in maternal vitamin D levels between the three groups/cohorts related to neonatal infections., secondaryOutcomes measure: Differences in maternal vitamin D levels between the three groups/cohorts related to the diagnosis of congenital malformations, secondaryOutcomes measure: Differences in the presence of vitamin D-related polymorphisms between the three groups/cohorts associated with prematurity, secondaryOutcomes measure: Differences in the presence of vitamin D-related polymorphisms between the three groups/cohorts associated with birth weight, secondaryOutcomes measure: Differences in the presence of vitamin D-related polymorphisms between the three groups/cohorts associated with Apgar scores, secondaryOutcomes measure: Differences in the presence of vitamin D-related polymorphisms between the three groups/cohorts associated with admission to the Neonatal Intensive Care Unit., secondaryOutcomes measure: Differences in the presence of vitamin D-related polymorphisms between the three groups/cohorts associated with neonatal morbidity, secondaryOutcomes measure: Differences in the presence of vitamin D-related polymorphisms between the three groups/cohorts associated with neonatal mortality, secondaryOutcomes measure: Differences in the presence of vitamin D-related polymorphisms between the three groups/cohorts associated with neonatal infections, secondaryOutcomes measure: Differences in the presence of vitamin D-related polymorphisms between the three groups/cohorts associated with the diagnosis of congenital malformations, eligibilityModule sex: FEMALE, minimumAge: 16 Years, stdAges: CHILD, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Unidade Local de Saúde do Baixo Alentejo, status: RECRUITING, city: Beja, zip: 7801-849, country: Portugal, contacts name: Inês Gornilho, MD, role: CONTACT, email: [email protected], geoPoint lat: 38.01506, lon: -7.86323, locations facility: Unidade Local de Saúde do Norte Alentejano, status: RECRUITING, city: Portalegre, zip: 7301-853, country: Portugal, contacts name: Vera Escoto, MD, role: CONTACT, email: [email protected], geoPoint lat: 39.29379, lon: -7.43122, locations facility: Unidade Local de Saúde do Alentejo Central - Hospital Espirito Santo de Évora, status: RECRUITING, city: Évora, zip: 7000-811, country: Portugal, contacts name: Maria OP Barbosa, MSc; PhD Student, role: CONTACT, phone: 00351966056178, email: [email protected], contacts name: Fernando Fernandes, MD, role: CONTACT, phone: 00351965753123, email: [email protected], geoPoint lat: 38.56667, lon: -7.9, hasResults: False |
protocolSection identificationModule nctId: NCT06292182, orgStudyIdInfo id: 160802, secondaryIdInfos id: 332942, type: OTHER, domain: IRAS, secondaryIdInfos id: 58964, type: OTHER, domain: CPMS, briefTitle: Red Light Ptosis Proof-of-Concept, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-02-08, primaryCompletionDateStruct date: 2025-11-30, completionDateStruct date: 2025-11-30, studyFirstPostDateStruct date: 2024-03-05, lastUpdatePostDateStruct date: 2024-03-05, sponsorCollaboratorsModule leadSponsor name: University College, London, class: OTHER, collaborators name: Moorfields Eye Hospital NHS Foundation Trust, descriptionModule briefSummary: This study tests a new treatment to help with droopy eyelids (ptosis) and eye movement problems (squint) in children and young people with genetically confirmed mitochondrial conditions - using red-light.We use a torch to shine a red light through the closed eyelid for 3 minutes a day. The study will run for 18 months.We believe that this treatment could help strengthen the muscle in the eyelid to make it easier to open the eyes, and could also help some children with squint., conditionsModule conditions: Mitochondrial Diseases, conditions: Blepharoptosis, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: SEQUENTIAL, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 10, type: ESTIMATED, armsInterventionsModule interventions name: Near-infrared light, outcomesModule primaryOutcomes measure: Palpebral fissure width, eligibilityModule sex: ALL, minimumAge: 3 Years, maximumAge: 18 Years, stdAges: CHILD, stdAges: ADULT, contactsLocationsModule locations facility: Moorfields Eye Hospital NHS Foundation Trust, status: RECRUITING, city: London, zip: EC1V 2PD, country: United Kingdom, contacts name: Annegret H Dahlmann-Noor, PhD, role: CONTACT, phone: 020 7253 3411, email: [email protected], geoPoint lat: 51.50853, lon: -0.12574, hasResults: False |
protocolSection identificationModule nctId: NCT06292169, orgStudyIdInfo id: STUDY00007201, briefTitle: Pectoralis Minor Release Versus Non-release in RSA, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-05, primaryCompletionDateStruct date: 2026-01, completionDateStruct date: 2026-01, studyFirstPostDateStruct date: 2024-03-05, lastUpdatePostDateStruct date: 2024-04-09, sponsorCollaboratorsModule leadSponsor name: Emory University, class: OTHER, descriptionModule briefSummary: The goal of this clinical trial is to assess if concomitant open pectoralis minor release would improve pain and outcomes after Reverse Shoulder Arthroplasty (RSA). The main questions it aims to answer are:* whether releasing the pectoralis minor prophylactically could have better pain relief* whether releasing the pectoralis minor prophylactically could have increased Range of motion (ROM) outcomes* whether releasing the pectoralis minor prophylactically could have higher final Patient Reported Outcome Measurements (PROMs) Participants will be randomized to either undergo RSA with pectoralis minor release or RSA without pectoralis minor release., conditionsModule conditions: Reverse Total Shoulder Arthroplasty, conditions: Rotator Cuff Tear Arthropathy, conditions: Advanced Glenohumeral Osteoarthritis, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: SINGLE, maskingDescription: Electronic random number generator Single-blinded (concealed to the study participant only, Investigator blinded not feasible), whoMasked: PARTICIPANT, enrollmentInfo count: 30, type: ESTIMATED, armsInterventionsModule interventions name: Pectoralis Minor Release, interventions name: RSA, outcomesModule primaryOutcomes measure: Visual analog Scale (VAS) pain scores, otherOutcomes measure: Visual analog Scale (VAS) pain scores, otherOutcomes measure: American Shoulder and Elbow Score (ASES), otherOutcomes measure: Subjective Shoulder Value (SSV), otherOutcomes measure: Change in Range of motion (ROM), otherOutcomes measure: Change in Scapulohumeral Rhythm (SHR) on Digital Dynamic Radiography (DDR), otherOutcomes measure: Number of complications, otherOutcomes measure: Number of reoperations, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Emory Clinic, city: Atlanta, state: Georgia, zip: 30322, country: United States, contacts name: Eric Wagner, MD, role: CONTACT, phone: 404-778-7249, email: [email protected], contacts name: Musab Gulzar, role: CONTACT, phone: 201-344-0298, email: [email protected], contacts name: Michael Gottschalk, MD, role: SUB_INVESTIGATOR, geoPoint lat: 33.749, lon: -84.38798, locations facility: Emory Healthcare Orthopaedics and Spine Center, city: Atlanta, state: Georgia, zip: 30329, country: United States, contacts name: Eric Wagner, MD, role: CONTACT, phone: 404-778-7249, email: [email protected], contacts name: Musab Gulzar, role: CONTACT, phone: 201-344-0298, email: [email protected], geoPoint lat: 33.749, lon: -84.38798, hasResults: False |
protocolSection identificationModule nctId: NCT06292156, orgStudyIdInfo id: CASPsy7, briefTitle: tACS Treatment for Cognitive Impairments in Methamphetamine Addicts, statusModule overallStatus: RECRUITING, startDateStruct date: 2023-02-20, primaryCompletionDateStruct date: 2024-08, completionDateStruct date: 2024-08, studyFirstPostDateStruct date: 2024-03-04, lastUpdatePostDateStruct date: 2024-03-04, sponsorCollaboratorsModule leadSponsor name: Beijing HuiLongGuan Hospital, class: OTHER, descriptionModule briefSummary: 1. To evaluate the cognitive function of methamphetamine Patients.2. Investigate the pathological mechanism of methamphetamine patients from the aspects of EEG and biology;3. The investigators investigated the effects of transcranial alternating current stimulation (tACS) on cognitive impairments in methamphetamine patients, conditionsModule conditions: Methamphetamine Abuse, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: TRIPLE, whoMasked: PARTICIPANT, whoMasked: INVESTIGATOR, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 300, type: ESTIMATED, armsInterventionsModule interventions name: Theta treatment group, interventions name: Alpha active control group, interventions name: Sham control group, outcomesModule primaryOutcomes measure: The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), primaryOutcomes measure: ERP components associated with cognitive function, primaryOutcomes measure: Condition stop signal task, primaryOutcomes measure: Neural oscillations associated with cognitive function, primaryOutcomes measure: Functional connection of brain region associated with cognitive function, primaryOutcomes measure: Microstate associated with cognitive function, primaryOutcomes measure: The effect of oxidative stress system on cognitive function, primaryOutcomes measure: The effect of immune system on cognitive function, primaryOutcomes measure: The effect of brain derived neurotrophic factor(BDNF) on cognitive function, primaryOutcomes measure: Genetic mechanism of cognitive function, secondaryOutcomes measure: Reverse learning task, secondaryOutcomes measure: Beck Depression Scale, secondaryOutcomes measure: Barrett impulse Scale, secondaryOutcomes measure: Degree of insomnia, secondaryOutcomes measure: The Sensitivity to Punishment and Reward Questionnaire, secondaryOutcomes measure: Visual analog scale, secondaryOutcomes measure: The Desires for Drug Questionnaire, secondaryOutcomes measure: Obsessive compulsive drug use scale, secondaryOutcomes measure: Obsessive-compulsive inventory, secondaryOutcomes measure: Thought Control Ability Questionnaire, secondaryOutcomes measure: Thought Suppression Questionnaire, secondaryOutcomes measure: Rumination Questionnaire, secondaryOutcomes measure: Anger Rumination Questionnaire, secondaryOutcomes measure: Beck Anxiety Scale, secondaryOutcomes measure: Emotional Regulation Difficulty Scale, secondaryOutcomes measure: Aggressive questionnair, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 55 Years, stdAges: ADULT, contactsLocationsModule locations facility: Xin Hua Drug Rehabilitation Center, status: RECRUITING, city: Mianyang, country: China, contacts name: China, role: CONTACT, geoPoint lat: 31.46784, lon: 104.68168, hasResults: False |
protocolSection identificationModule nctId: NCT06292143, orgStudyIdInfo id: EU101136769-CLIN2, briefTitle: AI4HOPE Dementia Care Planning Pilot Study 2 ( AI4HOPE2), acronym: AI4HOPE-P2, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2025-07, primaryCompletionDateStruct date: 2026-12, completionDateStruct date: 2026-12, studyFirstPostDateStruct date: 2024-03-04, lastUpdatePostDateStruct date: 2024-03-04, sponsorCollaboratorsModule leadSponsor name: University of Bonn, class: OTHER, collaborators name: University College Cork, collaborators name: University of Leeds, collaborators name: Fundacion Intras, collaborators name: Universidade do Porto, collaborators name: University Medical Centre Maribor, descriptionModule briefSummary: This pilot study will test a digital care planning decision support system for patients with dementia., conditionsModule conditions: Dementia, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NA, interventionModel: SINGLE_GROUP, interventionModelDescription: Feasibility study, primaryPurpose: SUPPORTIVE_CARE, maskingInfo masking: NONE, enrollmentInfo count: 150, type: ESTIMATED, armsInterventionsModule interventions name: Advance Care Planning Toolkit, outcomesModule primaryOutcomes measure: Ease of use of digital platform, primaryOutcomes measure: Effect of digital platform on documentation of advance care planning, eligibilityModule sex: ALL, stdAges: CHILD, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: University Hospital Bonn, city: Bonn, zip: 53127, country: Germany, geoPoint lat: 50.73438, lon: 7.09549, hasResults: False |
protocolSection identificationModule nctId: NCT06292130, orgStudyIdInfo id: 156588-01, briefTitle: Health-Kit Enabled Mobile App for Tobacco Cessation, statusModule overallStatus: COMPLETED, startDateStruct date: 2022-03-21, primaryCompletionDateStruct date: 2023-09-21, completionDateStruct date: 2023-09-21, studyFirstPostDateStruct date: 2024-03-04, lastUpdatePostDateStruct date: 2024-03-04, sponsorCollaboratorsModule leadSponsor name: Pro-Change Behavior Systems, class: OTHER, descriptionModule briefSummary: Tobacco use remains the leading preventable cause of death in the US, contributing to more than 480,000 premature deaths each year. The Tobacco Treatment Guidelines underscore the need to offer patients who use tobacco products brief interventions that include prescriptions for proven pharmacological smoking cessation aids and proactive connections to evidence-based behavioral support. The rapid expansion of smart phone capabilities enhances the potential for tobacco cessation apps to personalize behavior change guidance and to send contextually relevant tailored behavior change nudges based on readiness to quit and electronic heath record (EHR) data. Rich data from EHRs are now available to third-party apps from the Health app (iOS) via Fast Healthcare Interoperability Resources standard Application Programming Interface (API).This Phase I SBIR will explore the acceptability and effects of one such innovative health IT solution. Refresh is a highly individualized tobacco cessation HealthKit enabled app that will 1) implement a full range of best practices in tailored health behavior change communications based on readiness to change; 2) individualize behavior change guidance based on Health app data; and 3) concisely provide data and documentation of key actionable insights in the EHR on the patient's smoking status, app usage, and brief micro-message clinicians can deliver to reinforce and accelerate a patient's behavior change progress. This interoperability will provide value to both patients and clinicians; empower and support successful and lasting behavior change; and enable the implementation and evaluation of a best-in-class approach to tobacco and nicotine treatment.Extensive end user and stakeholder input will ensure refresh is designed for rapid dissemination. Patients of an integrated delivery system with an upcoming appointment (n=100) will be recruited to participate in a 30-day pilot test. Pilot participants will provide quantitative and qualitative data, and utilization and acceptability data will be examined. Pre-post comparisons of PROMIS measure for tobacco (psychosocial expectancies) will provide preliminary data on the effects of the program. Acceptability data from participating clinicians (n=10) who receive and deliver EHR prompts will also be gathered. The hypothesis is that the patients who utilize refresh will have significantly higher psychosocial expectancies regarding tobacco at follow-up. Secondary outcomes will be examined., conditionsModule conditions: Cigarette Smoking, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NA, interventionModel: SINGLE_GROUP, interventionModelDescription: Single group, repeated measures (2 timepoints), primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 51, type: ACTUAL, armsInterventionsModule interventions name: refresh, outcomesModule primaryOutcomes measure: Psychosocial Expectancies (PROMIS Smoking Initiative) Patient Reported Outcome, secondaryOutcomes measure: Confidence, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Pro-Change Behavior Systems, Inc, city: South Kingstown, state: Rhode Island, zip: 02879, country: United States, geoPoint lat: 41.44718, lon: -71.52494, hasResults: False |
protocolSection identificationModule nctId: NCT06292117, orgStudyIdInfo id: 230247, briefTitle: Implementation of Onsite Rapid CYP2C19 Assay for Genotype Guided Dual Antiplatelet Therapy After Acute Ischemic Stroke, acronym: ORCA-AIS, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-03, primaryCompletionDateStruct date: 2026-06, completionDateStruct date: 2026-06, studyFirstPostDateStruct date: 2024-03-04, lastUpdatePostDateStruct date: 2024-03-04, sponsorCollaboratorsModule leadSponsor name: University of Virginia, class: OTHER, collaborators name: American Heart Association, descriptionModule briefSummary: The goal of this observational study is to use a genetic test to help doctors prescribe the most effective medications after a patient has a stroke. One type of stroke is caused by a blood clot in brain vessels. After a patient has this kind of stroke, they are often given a combination of two blood thinners to prevent it from happening again. One of these blood thinners, called clopidogrel, is less effective in some people due to differences in their DNA. Clopidogrel needs to be activated by a specific enzyme in the body known as CYP2C19. This enzyme does not work as well if there are variations in the section of DNA that tells the body how to make CYP2C19. It can be predicted who has less CYP2C19 enzyme activity with a genetic test. If these patients are given a different blood thinner, it can reduce their risk of another stroke compared to if they are given clopidogrel.The main questions this study aims to answer are:* What are the best strategies to implement this genetic test in the hospital?* Does implementation of this genetic test change providers' decisions on which medication to prescribe after a participant has a stroke?Participants in this study will have a genetic test done onsite looking for variations in the section of DNA that tells the body how to make CYP2C19. This genetic test will only look for 11 known variations; the genome will not be sequenced. The investigators will alert the doctor of the patient's test results so they can prescribe the appropriate blood thinner. Through this, the investigators will learn the best practices for successful implementation of this genetic test., conditionsModule conditions: Ischemic Stroke, conditions: CYP2C19 Polymorphism, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 350, type: ESTIMATED, armsInterventionsModule interventions name: CYP2C19 Genotype, outcomesModule primaryOutcomes measure: Percentage of patients discharged from University of Virginia (UVA) Health on dual antiplatelet therapy with a diagnosis of AIS/TIA meeting eligibility criteria upon presentation that are successfully genotyped, primaryOutcomes measure: Average turnaround time of genotype result from time of collection of blood sample to time result is entered into the electronic health record, secondaryOutcomes measure: Number of CYP2C19 LOF carriers for whom a genotype-guided modification to DAPT is made, secondaryOutcomes measure: Number needed to genotype (NNG): number of patients who would need to undergo genotyping to have a recommended change in DAPT based on genotype, secondaryOutcomes measure: Stroke-free status via the Questionnaire to Verify Stroke-Free Status (QVSFS) of participants at 90 days in participants who received DAPT, secondaryOutcomes measure: Major adverse cardiovascular events at 90 days in participants who received DAPT, secondaryOutcomes measure: Correlation between P2Y12 reaction units (PRUs) measured via P2Y12 assay and CYP2C19 genotype in patients who received DAPT, otherOutcomes measure: Acceptability of deferred consent process in participants approached for full informed consent, otherOutcomes measure: Cost-effectiveness of CYP2C19-guided dual antiplatelet therapy after acute ischemic stroke, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False |
protocolSection identificationModule nctId: NCT06292104, orgStudyIdInfo id: STU-2023-0589, secondaryIdInfos id: 1R01HL166272-01A1, type: NIH, link: https://reporter.nih.gov/quickSearch/1R01HL166272-01A1, briefTitle: Phenotyping of Postural Orthostatic Tachycardia Syndrome (POTS), statusModule overallStatus: RECRUITING, startDateStruct date: 2024-03-05, primaryCompletionDateStruct date: 2028-12, completionDateStruct date: 2029-01, studyFirstPostDateStruct date: 2024-03-04, lastUpdatePostDateStruct date: 2024-04-26, sponsorCollaboratorsModule leadSponsor name: University of Texas Southwestern Medical Center, class: OTHER, collaborators name: National Heart, Lung, and Blood Institute (NHLBI), descriptionModule briefSummary: This is an observational study to deeply phenotype the disorder of POTS using multiple testing modalities., conditionsModule conditions: Postural Orthostatic Tachycardia Syndrome, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: CROSS_SECTIONAL, enrollmentInfo count: 350, type: ESTIMATED, armsInterventionsModule interventions name: multimodal diagnostic testing, outcomesModule primaryOutcomes measure: Phenotyping POTS, primaryOutcomes measure: Natural history, primaryOutcomes measure: Natural history, eligibilityModule sex: ALL, minimumAge: 14 Years, stdAges: CHILD, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: UT Southwestern Medical Center, status: RECRUITING, city: Dallas, state: Texas, zip: 75208, country: United States, contacts name: Steven Hopkins, role: CONTACT, phone: 214-648-9275, email: [email protected], contacts name: Steven Hopkins, role: CONTACT, phone: 2146489275, email: [email protected], contacts name: Steven Vernino, MD, PhD, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 32.78306, lon: -96.80667, hasResults: False |
protocolSection identificationModule nctId: NCT06292091, orgStudyIdInfo id: Ur_ABD_PK, briefTitle: A Study to Investigate the Effect of Urine Acid-base Disequilibrium on the Pharmacokinetics of Captopril, statusModule overallStatus: COMPLETED, startDateStruct date: 2024-02-28, primaryCompletionDateStruct date: 2024-03-27, completionDateStruct date: 2024-04-01, studyFirstPostDateStruct date: 2024-03-04, lastUpdatePostDateStruct date: 2024-04-17, sponsorCollaboratorsModule leadSponsor name: Seoul National University Hospital, class: OTHER, descriptionModule briefSummary: The aim of this study is to evaluate the effect of urine acid-base disequilibrium on the pharmacokinetics of captopril in healthy male volunteers., conditionsModule conditions: Hypertension, designModule studyType: INTERVENTIONAL, phases: PHASE1, designInfo allocation: NON_RANDOMIZED, interventionModel: SEQUENTIAL, primaryPurpose: OTHER, maskingInfo masking: NONE, enrollmentInfo count: 12, type: ACTUAL, armsInterventionsModule interventions name: Captopril 12.5 Mg, interventions name: Sodium bicarbonate 4 G, interventions name: Torsemide 20 MG, outcomesModule primaryOutcomes measure: AUClast of captopril, primaryOutcomes measure: Cmax of captopril, secondaryOutcomes measure: AUCinf of captopril, secondaryOutcomes measure: Tmax of captopril, secondaryOutcomes measure: t1/2 of captopril, secondaryOutcomes measure: CL/F of captopril, secondaryOutcomes measure: Vd/F of captopril, secondaryOutcomes measure: fe of captopril, secondaryOutcomes measure: urine pH, secondaryOutcomes measure: Safety parameters, eligibilityModule sex: MALE, minimumAge: 19 Years, maximumAge: 50 Years, stdAges: ADULT, contactsLocationsModule locations facility: Seoul National University Hospital, city: Seoul, zip: 03080, country: Korea, Republic of, geoPoint lat: 37.566, lon: 126.9784, hasResults: False |
protocolSection identificationModule nctId: NCT06292078, orgStudyIdInfo id: 1R01DA059401-01, type: NIH, link: https://reporter.nih.gov/quickSearch/1R01DA059401-01, secondaryIdInfos id: 1R01DA059401-01, type: NIH, link: https://reporter.nih.gov/quickSearch/1R01DA059401-01, briefTitle: Preventing School Exclusion and Opioid Misuse: Effectiveness of the Inclusive Skill-building Learning Approach (ISLA), acronym: ISLA, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-06, primaryCompletionDateStruct date: 2028-08, completionDateStruct date: 2028-08, studyFirstPostDateStruct date: 2024-03-04, lastUpdatePostDateStruct date: 2024-03-04, sponsorCollaboratorsModule leadSponsor name: University of Oregon, class: OTHER, collaborators name: National Institute on Drug Abuse (NIDA), descriptionModule briefSummary: This project will test the effectiveness of the Inclusive Skill-building Learning Approach (ISLA) in reducing the use of exclusionary discipline, improving teacher practice and student outcomes, and decreasing substance misuse using a randomized controlled trial in 60 middle schools across six states., conditionsModule conditions: Opioid Misuse, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: PREVENTION, maskingInfo masking: SINGLE, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 5076, type: ESTIMATED, armsInterventionsModule interventions name: Instructional Skill-Building Learning Approach (ISLA), outcomesModule primaryOutcomes measure: Frequency and Duration of Use of Office Discipline Referrals, In-School Suspension, and Out-of-School Suspension, primaryOutcomes measure: Engagement vs. Disaffection with Learning Student-report, primaryOutcomes measure: Inclusive Teaching Practices, primaryOutcomes measure: School Climate Survey- Student, primaryOutcomes measure: School Climate- Teacher, primaryOutcomes measure: Student-Teacher Relationships, primaryOutcomes measure: Opioid and Other Substance Misuse, primaryOutcomes measure: Student Internalizing Behaviors, primaryOutcomes measure: Student Externalizing Behaviors, primaryOutcomes measure: ISLA Acceptability, primaryOutcomes measure: ISLA Implementation Fidelity, eligibilityModule sex: ALL, minimumAge: 8 Years, maximumAge: 15 Years, stdAges: CHILD, contactsLocationsModule, hasResults: False |
protocolSection identificationModule nctId: NCT06292065, orgStudyIdInfo id: Project ID 6171, briefTitle: Gastric Ultrasound To Assess Gastric Contents In Patients On Semaglutide Therapy, acronym: GUST, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-04-14, primaryCompletionDateStruct date: 2024-12-31, completionDateStruct date: 2024-12-31, studyFirstPostDateStruct date: 2024-03-04, lastUpdatePostDateStruct date: 2024-04-05, sponsorCollaboratorsModule leadSponsor name: Nils Vlaeminck, class: OTHER, descriptionModule briefSummary: Glucagon-like peptide-1 (GLP-1) receptor agonists (GLP-1-RA) such as semaglutide (Ozempic™, Rybelsus™, Wegovy™) were first introduced as a therapeutic agent for type 2 diabetes mellitus but they are being increasingly used to target weight loss in obesity.One of the mechanisms by which weight loss is achieved, is increased satiety and significantly delayed gastric emptying. Tachyphylaxis for this effect has been reported with chronic use of long acting GLP-1-RA (e.g. semaglutide) but this was based on the paracetamol absorption technique or 13C breath test. Recent clinical data suggests semaglutide use does increase perioperative gastric content.This creates uncertainty for anaesthetists who are, anecdotally, more frequently faced with patients who may or may not have full stomachs despite adhering to conventional fasting guidelines.To address this issue the American Society of Anesthesiologists (ASA) has recently released guidelines in which it advises to hold GLP-1-RA for one day (if administered daily) or one week (if administered weekly).However, these recommendations are based on sparse empirical evidence and they do not necessarily follow from the known pharmacokinetic properties of these drugs. Typically, GLP-1-RA are administered in increasing doses over several weeks until a therapeutic steady state is achieved. Meanwhile the elimination half-life of e.g. semaglutide is 7 days. This means that holding semaglutide for one day or even one week might not be enough to attenuate its therapeutic effect of delayed gastric emptying. On the other hand if semaglutide were to be held for e.g. 5 terminal half-lifes, this would mean an unpractical 5 weeks during which glycemic control may be worsened and after which semaglutide doses would have to be incrementally increased again. Besides, hyperglycaemia secondary to semaglutide cessation can also delay gastric emptying.Further confounding the assessment of these patients there can be 'background' delayed gastric emptying in diabetic patients and more pronounced delayed gastric emptying in patients recently started on GLP-1-RA. The presence of gastro-intestinal symptoms (nausea, vomiting, dyspepsia, abdominal distension) might offer clinical information regarding increased gastric residue in this population.Gastric ultrasound is a point-of-care clinical and research tool that has steadily gained popularity to assess gastric content in patients not compliant with fasting rules or with certain comorbidities. Clinical decisions can be made based on the visualised content (e.g. solids, fluids or nothing) or through calculation of gastric volume by measuring antral circumference. In this study the investigators will examine gastric contents in patients who are taking semaglutide and in patients who are not. The investigators will then evaluate whether there is a difference in the incidence of full stomachs and whether gastric ultrasound influenced the anaesthetic plan of the treating anaesthetist., conditionsModule conditions: Gastroparesis, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NA, interventionModel: SINGLE_GROUP, interventionModelDescription: 45 patients on semaglutide therapy will be included together with 45 age, BMI and diabetes status matched controls., primaryPurpose: DIAGNOSTIC, maskingInfo masking: NONE, enrollmentInfo count: 90, type: ESTIMATED, armsInterventionsModule interventions name: Point-of-care gastric ultrasound, outcomesModule primaryOutcomes measure: Prevalence of full stomach, secondaryOutcomes measure: Frequency of changes to the anaesthetic plan, secondaryOutcomes measure: Calculated gastric content, secondaryOutcomes measure: Prevalence of solid gastric content, secondaryOutcomes measure: Association between fasting time for solids and 'full stomach', secondaryOutcomes measure: Association between fasting time for liquids and 'full stomach', secondaryOutcomes measure: Frequency of perioperative aspiration, secondaryOutcomes measure: Prevalence of gastric symptoms, secondaryOutcomes measure: Association between nausea and 'full stomach', secondaryOutcomes measure: Association between vomiting and 'full stomach', secondaryOutcomes measure: Association between dyspepsia and 'full stomach', secondaryOutcomes measure: Association between abdominal distension and 'full stomach', secondaryOutcomes measure: association between semaglutide dose and calculated gastric content, secondaryOutcomes measure: association between semaglutide dose and 'full stomach', secondaryOutcomes measure: Association between frequency of semaglutide administration and calculated gastric content, secondaryOutcomes measure: Association between frequency of semaglutide administration and 'full stomach', secondaryOutcomes measure: Association between duration of semaglutide therapy and calculated gastric content, secondaryOutcomes measure: Association between duration of semaglutide therapy at current dose and calculated gastric content, secondaryOutcomes measure: Association between duration of semaglutide therapy and 'full stomach', secondaryOutcomes measure: Association between duration of semaglutide therapy at current dose and 'full stomach', secondaryOutcomes measure: Association between duration of cessation of semaglutide and calculated gastric content, secondaryOutcomes measure: Association between duration of cessation of semaglutide and 'full stomach', secondaryOutcomes measure: Association between preoperative blood glucose levels and calculated gastric content, secondaryOutcomes measure: Association between preoperative blood glucose levels and 'full stomach', secondaryOutcomes measure: Association between HbA1c levels and calculated gastric content, secondaryOutcomes measure: Association between HbA1c levels and 'full stomach', secondaryOutcomes measure: Association between time since onset of diabetes mellitus and calculated gastric content, secondaryOutcomes measure: Association between time since onset of diabetes mellitus and 'full stomach', eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Antwerp University Hospital, status: RECRUITING, city: Edegem, state: Antwerp, zip: 2650, country: Belgium, contacts name: Nils Vlaeminck, role: CONTACT, phone: 038215865, email: [email protected], contacts name: Vera Saldien, role: CONTACT, phone: 038214788, email: [email protected], geoPoint lat: 51.15662, lon: 4.44504, hasResults: False |
protocolSection identificationModule nctId: NCT06292052, orgStudyIdInfo id: NSCLC-TDLN-001, briefTitle: Relation Between Tumor-draining Lymph Nodes Metastasis Pattern and Non-small Cell Lung Cancer Neoadjuvant Immunotherapy Effectiveness, statusModule overallStatus: RECRUITING, startDateStruct date: 2017-01-01, primaryCompletionDateStruct date: 2024-03-01, completionDateStruct date: 2024-04-01, studyFirstPostDateStruct date: 2024-03-04, lastUpdatePostDateStruct date: 2024-03-04, sponsorCollaboratorsModule leadSponsor name: Sun Yat-sen University, class: OTHER, collaborators name: Jiangmen Central Hospital, collaborators name: Henan Cancer Hospital, descriptionModule briefSummary: The goal of this retrospective cohort analysis is to discover the impact of the involvement extent of tumor-draining lymph nodes (TDLNs) in patients who received neoadjuvant immunochemotherapy. The main question it aims to answer is the role of TDLN in the prediction of treatment effectiveness. Researches will compare tumor-draining lymph nodes metastasis (mTDLNs) group and non-draining lymph nodes metastasis (mNDLNs) group to see whether different metastatic patterns of mediastinal lymph nodes can indicate the treatment effectiveness., conditionsModule conditions: Lung Cancer, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: RETROSPECTIVE, enrollmentInfo count: 350, type: ESTIMATED, armsInterventionsModule interventions name: Immunotherapy, outcomesModule primaryOutcomes measure: Complete pathologic response, secondaryOutcomes measure: Major pathologic response, secondaryOutcomes measure: Complete pathologic response in lymph nodes, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 80 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Sun Yat-sen University Cancer Center, status: RECRUITING, city: Guangzhou, state: Guangdong, zip: 510060, country: China, contacts name: Hao Long, MD, role: CONTACT, phone: +86-13802770989, email: [email protected], geoPoint lat: 23.11667, lon: 113.25, hasResults: False |
protocolSection identificationModule nctId: NCT06292039, orgStudyIdInfo id: P0555788, secondaryIdInfos id: 2KL2TR001870, type: NIH, link: https://reporter.nih.gov/quickSearch/2KL2TR001870, briefTitle: Human-centered Injury Thrivorship Pathway for Survivors of Physical Trauma, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2025-07, primaryCompletionDateStruct date: 2026-04, completionDateStruct date: 2026-06, studyFirstPostDateStruct date: 2024-03-04, lastUpdatePostDateStruct date: 2024-03-06, sponsorCollaboratorsModule leadSponsor name: University of California, San Francisco, class: OTHER, collaborators name: National Center for Advancing Translational Sciences (NCATS), descriptionModule briefSummary: The goal of this clinical trial is to pilot and evaluate a human-centered injury thrivorship pathway in injury survivors. The main question it aims to answer is:• Is the pathway appropriate, acceptable, and feasible to meet the medical and social needs of injury survivors?Injury survivors will be purposively sampled to enroll in the pathway and asked to participate in in-depth interviews and their use of pathway resources will be tracked., conditionsModule conditions: Injury Traumatic, conditions: Survivorship, conditions: Trauma Injury, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NA, interventionModel: SINGLE_GROUP, primaryPurpose: HEALTH_SERVICES_RESEARCH, maskingInfo masking: NONE, enrollmentInfo count: 25, type: ESTIMATED, armsInterventionsModule interventions name: Human-Centered Injury Thrivorship Pathway, outcomesModule primaryOutcomes measure: Early Implementation Outcomes - Acceptability, Appropriateness, Feasibility, secondaryOutcomes measure: Participant pathway resource utilization - type, secondaryOutcomes measure: Participant pathway resource utilization - frequency, secondaryOutcomes measure: Participant pathway resource utilization - duration, secondaryOutcomes measure: Participant pathway resource utilization - % utilized, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Zuckerberg San Francisco General Hospital, city: San Francisco, state: California, zip: 94110, country: United States, contacts name: Marissa A Boeck, MD, MPH, role: CONTACT, phone: 415-502-4745, email: [email protected], geoPoint lat: 37.77493, lon: -122.41942, hasResults: False |
protocolSection identificationModule nctId: NCT06292026, orgStudyIdInfo id: DFU/1, briefTitle: Efficacy of ProgenaMatrix™ in the Management of DFUs, statusModule overallStatus: ACTIVE_NOT_RECRUITING, startDateStruct date: 2022-03-14, primaryCompletionDateStruct date: 2026-03, completionDateStruct date: 2026-09, studyFirstPostDateStruct date: 2024-03-04, lastUpdatePostDateStruct date: 2024-03-04, sponsorCollaboratorsModule leadSponsor name: ProgenaCare Global, LLC, class: INDUSTRY, descriptionModule briefSummary: This multicenter study will collect data to determine closure time for diabetic ulcers when following protocol parameters and treatment with ProgenaMatrix™., conditionsModule conditions: Diabetic Foot Ulcer, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NA, interventionModel: SINGLE_GROUP, interventionModelDescription: The objective of this data collection is to look at outcomes and time points for ProgenaMatrix™ in the treatment of diabetic foot ulcers. Additionally, use the collected data to develop predictive wound closure models. There is a 1-week lead in period after initial debridement. If the wound is rapidly moving to closure after initial debridement and standard moist dressings, the withdrawal of these patients will prevent corruption of the true closure rate of ProgenaMatrix™. The objective of the treatment with ProgenaMatrix™ is to evaluate the closure rate in patients not responding to traditional moist therapy., primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 100, type: ACTUAL, armsInterventionsModule interventions name: ProgenaMatrix Keratin graft, interventions name: standard of care, outcomesModule primaryOutcomes measure: time to wound closure, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 85 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: United Wound Healing, city: Puyallup, state: Washington, zip: 98371, country: United States, geoPoint lat: 47.18538, lon: -122.2929, hasResults: False |
protocolSection identificationModule nctId: NCT06292013, orgStudyIdInfo id: 18812, secondaryIdInfos id: J3L-MC-EZEF, type: OTHER, domain: Eli Lilly and Company, secondaryIdInfos id: 2023-509190-23, type: EUDRACT_NUMBER, briefTitle: A Study to Investigate the Effect of Lepodisiran on the Reduction of Major Adverse Cardiovascular Events in Adults With Elevated Lipoprotein(a) - ACCLAIM-Lp(a), statusModule overallStatus: RECRUITING, startDateStruct date: 2024-03-05, primaryCompletionDateStruct date: 2029-03, completionDateStruct date: 2029-03, studyFirstPostDateStruct date: 2024-03-04, lastUpdatePostDateStruct date: 2024-04-29, sponsorCollaboratorsModule leadSponsor name: Eli Lilly and Company, class: INDUSTRY, descriptionModule briefSummary: The purpose of this study is to evaluate the efficacy of lepodisiran in reducing cardiovascular risk in participants with high lipoprotein(a) who have cardiovascular disease or are at risk of a heart attack or stroke. The study drug will be administered subcutaneously (SC) (under the skin)., conditionsModule conditions: Atherosclerotic Cardiovascular Disease (ASCVD), conditions: Elevated Lp(a), designModule studyType: INTERVENTIONAL, phases: PHASE3, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: DOUBLE, whoMasked: PARTICIPANT, whoMasked: INVESTIGATOR, enrollmentInfo count: 12500, type: ESTIMATED, armsInterventionsModule interventions name: Lepodisiran Sodium, interventions name: Placebo, outcomesModule primaryOutcomes measure: Time to First Occurrence of Any Component of the Major Adverse Cardiac Event (MACE)-4 Composite Endpoint, secondaryOutcomes measure: Change from Baseline in Lipoprotein(a) [Lp(a)] at Week 4, secondaryOutcomes measure: Time to First Occurrence of Any of the Component of MACE-3 Composite Endpoint, secondaryOutcomes measure: Time to First Occurrence of Fatal or Non-Fatal Myocardial Infarction, secondaryOutcomes measure: Time to Cardiovascular Death, secondaryOutcomes measure: Time to Occurrence of All-Cause Death, secondaryOutcomes measure: Time to First Occurrence of Any Component of the MACE-4 Composite Endpoint (In the Population with Established ASCVD and CV Event, or Revascularization), secondaryOutcomes measure: Time to First Occurrence of any Component of the MACE-4 Composite Endpoint (In the Population At Risk for First CV event), secondaryOutcomes measure: Time to First Occurrence of any Component of the MACE-4 Composite Endpoint (In the Population with Lp(a) ≥ 200 nmol/L), secondaryOutcomes measure: Time to First Occurrence of Any Component of MACE-3 + MALE Composite Endpoint, secondaryOutcomes measure: Time to First Occurrence of Any Component of Coronary MACE-3 Composite Endpoint, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Birmingham Clinical Research, status: RECRUITING, city: Birmingham, state: Alabama, zip: 35209, country: United States, contacts name: Nova Law, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 33.52066, lon: -86.80249, locations facility: Alliance for Multispecialty Research, LLC, status: RECRUITING, city: Daphne, state: Alabama, zip: 36526, country: United States, contacts name: Michael T. Ledet, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 30.60353, lon: -87.9036, locations facility: SEC Clinical Research, status: RECRUITING, city: Dothan, state: Alabama, zip: 36305, country: United States, contacts name: Andreas Muench, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 31.22323, lon: -85.39049, locations facility: Alliance for Multispecialty Research, LLC, status: RECRUITING, city: Mobile, state: Alabama, zip: 36608, country: United States, contacts name: Harry E Studdard, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 30.69436, lon: -88.04305, locations facility: Mobile Heart Specialists, status: RECRUITING, city: Mobile, state: Alabama, zip: 36608, country: United States, contacts name: Christopher S. Brown, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 30.69436, lon: -88.04305, locations facility: Alaska Heart and Vascular Institute, status: NOT_YET_RECRUITING, city: Anchorage, state: Alaska, zip: 99508, country: United States, contacts name: Jacob Kelly, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 61.21806, lon: -149.90028, locations facility: Prime Medical Group, LLC dba Gilbert Center for Family Medicine, LLC, status: RECRUITING, city: Gilbert, state: Arizona, zip: 85296, country: United States, contacts name: Sunildat Maheshwari, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 33.35283, lon: -111.78903, locations facility: Mercy Gilbert Medical Center, status: NOT_YET_RECRUITING, city: Gilbert, state: Arizona, zip: 85297, country: United States, contacts name: Nabil Dib, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 33.35283, lon: -111.78903, locations facility: AMZERN Clinical Trial Organization, status: RECRUITING, city: Peoria, state: Arizona, zip: 85381, country: United States, contacts name: Kishlay Anand, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 33.5806, lon: -112.23738, locations facility: Elite Clinical Studies, status: RECRUITING, city: Phoenix, state: Arizona, zip: 85018, country: United States, contacts name: Joseph Lillo, DO, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 33.44838, lon: -112.07404, locations facility: Helios Clinical Research - Phoenix, status: RECRUITING, city: Phoenix, state: Arizona, zip: 85028, country: United States, contacts name: David Francyk, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 33.44838, lon: -112.07404, locations facility: Absolute Clinical Research, status: RECRUITING, city: Phoenix, state: Arizona, zip: 85051, country: United States, contacts name: James Beach, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 33.44838, lon: -112.07404, locations facility: Clinical Research Institute of Arizona (CRI) - Sun City West, status: RECRUITING, city: Sun City West, state: Arizona, zip: 85375, country: United States, contacts name: Jalal Abbas, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 33.66198, lon: -112.34127, locations facility: Synexus Clinical Research US, Inc./Orange Grove Family Practice, status: RECRUITING, city: Tucson, state: Arizona, zip: 85741, country: United States, contacts name: Kevin Lee Pounds, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 32.22174, lon: -110.92648, locations facility: Eclipse Clinical Research, status: NOT_YET_RECRUITING, city: Tucson, state: Arizona, zip: 85745, country: United States, contacts name: Eve C Shapiro, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 32.22174, lon: -110.92648, locations facility: Cardiology and Medicine Clinic, status: NOT_YET_RECRUITING, city: Little Rock, state: Arkansas, zip: 72204, country: United States, contacts name: Joe Louis Hargrove, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 34.74648, lon: -92.28959, locations facility: Westside Medical Associates of Los Angeles, status: NOT_YET_RECRUITING, city: Beverly Hills, state: California, zip: 90211, country: United States, contacts name: Norman ELLIOTT Lepor, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 34.07362, lon: -118.40036, locations facility: Valley Clinical Trials, Inc., status: RECRUITING, city: Covina, state: California, zip: 91723, country: United States, contacts name: Fahed G Bitar, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 34.09001, lon: -117.89034, locations facility: Neighborhood Healthcare Institute of Health, status: RECRUITING, city: Escondido, state: California, zip: 92025, country: United States, contacts name: James H Schultz, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 33.11921, lon: -117.08642, locations facility: HB Clinical Trials - Fountain Valley, status: RECRUITING, city: Fountain Valley, state: California, zip: 92708, country: United States, contacts name: Vinod Malhotra, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 33.70918, lon: -117.95367, locations facility: Care Access Research - Huntington Beach, status: RECRUITING, city: Huntington Beach, state: California, zip: 92648, country: United States, contacts name: Christine Thai, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 33.6603, lon: -117.99923, locations facility: 310 Clinical Research, status: RECRUITING, city: Inglewood, state: California, zip: 90301, country: United States, contacts name: Soheil Hekmat, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 33.96168, lon: -118.35313, locations facility: UCSD - Altman Clinical and Translational Research Institute (ACTRI), status: NOT_YET_RECRUITING, city: La Jolla, state: California, zip: 92037-7410, country: United States, contacts name: Michael Wilkinson, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 32.84727, lon: -117.2742, locations facility: Scripps Whittier Diabetes Institute, status: NOT_YET_RECRUITING, city: La Jolla, state: California, zip: 92037, country: United States, contacts name: James David McCallum, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 32.84727, lon: -117.2742, locations facility: First Valley Medical Group, status: NOT_YET_RECRUITING, city: Lancaster, state: California, zip: 93534, country: United States, contacts name: Kanagaratnam Sivalingam, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 34.69804, lon: -118.13674, locations facility: MemorialCare Health System - Long Beach Medical Center, status: NOT_YET_RECRUITING, city: Long Beach, state: California, zip: 90806, country: United States, contacts name: Mark Lee, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 33.76696, lon: -118.18923, locations facility: Ark Clinical Research, status: RECRUITING, city: Long Beach, state: California, zip: 90815, country: United States, contacts name: Apinya Vutikullird, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 33.76696, lon: -118.18923, locations facility: Keck School of Medicine of USC, status: NOT_YET_RECRUITING, city: Los Angeles, state: California, zip: 90033, country: United States, contacts name: Parveen Garg, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 34.05223, lon: -118.24368, locations facility: Cardiovascular Research Foundation of Southern California, status: NOT_YET_RECRUITING, city: Los Angeles, state: California, zip: 90210, country: United States, contacts name: Ronald P Karlsberg, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 34.05223, lon: -118.24368, locations facility: Desert Oasis Healthcare Medical Group, status: RECRUITING, city: Palm Springs, state: California, zip: 92262, country: United States, contacts name: Michael Jardula, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 33.8303, lon: -116.54529, locations facility: Artemis Institute for Clinical Research, status: NOT_YET_RECRUITING, city: San Diego, state: California, zip: 92103, country: United States, contacts name: Stacey Layle, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 32.71533, lon: -117.15726, locations facility: Care Access - Santa Clarita, status: RECRUITING, city: Santa Clarita, state: California, zip: 91321, country: United States, contacts name: Sina Tebi, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 34.39166, lon: -118.54259, locations facility: Millennium Clinical Trials, status: RECRUITING, city: Simi Valley, state: California, zip: 93065, country: United States, contacts name: Edward Portnoy, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 34.26945, lon: -118.78148, locations facility: Stanford University Medical Center, status: NOT_YET_RECRUITING, city: Stanford, state: California, zip: 94305, country: United States, contacts name: Abha Khandelwal, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 37.42411, lon: -122.16608, locations facility: Olive View-UCLA Medical Center, status: NOT_YET_RECRUITING, city: Sylmar, state: California, zip: 91342, country: United States, contacts name: Jonathan Soverow, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 34.30778, lon: -118.44925, locations facility: Care Access - Thousand Oaks, status: RECRUITING, city: Thousand Oaks, state: California, zip: 91360, country: United States, contacts name: Irving Loh, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 34.17056, lon: -118.83759, locations facility: Med Partners, Inc. dba Premiere Medical Center of Burbank, Inc., status: RECRUITING, city: Toluca Lake, state: California, zip: 91602, country: United States, contacts name: Michael Marsh, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 34.15262, lon: -118.35731, locations facility: Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, status: NOT_YET_RECRUITING, city: Torrance, state: California, zip: 90502, country: United States, contacts name: William French, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 33.83585, lon: -118.34063, locations facility: UCLA South Bay Endocrinology, status: NOT_YET_RECRUITING, city: Torrance, state: California, zip: 90505, country: United States, contacts name: Dianne Cheung, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 33.83585, lon: -118.34063, locations facility: InvivoCure, status: RECRUITING, city: Van Nuys, state: California, zip: 91405, country: United States, contacts name: Rodney Samaan, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 34.18667, lon: -118.44897, locations facility: Synexus Clinical Research US - Vista, status: RECRUITING, city: Vista, state: California, zip: 92083, country: United States, contacts name: Isabel J. Pereira, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 33.20004, lon: -117.24254, locations facility: Interventional Cardiology Medical Group, status: RECRUITING, city: West Hills, state: California, zip: 91307, country: United States, contacts name: Farhad Rafii, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 34.19731, lon: -118.64398, locations facility: University of Colorado Anschutz Medical Campus, status: RECRUITING, city: Aurora, state: Colorado, zip: 80045, country: United States, contacts name: Neda Rasouli, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 39.72943, lon: -104.83192, locations facility: Bridgeport Hospital, status: RECRUITING, city: Bridgeport, state: Connecticut, zip: 06610, country: United States, contacts name: Adam Schussheim, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 41.16704, lon: -73.20483, locations facility: Hartford Hospital (HH), status: NOT_YET_RECRUITING, city: Hartford, state: Connecticut, zip: 06102, country: United States, contacts name: Antonio Fernandez, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 41.76371, lon: -72.68509, locations facility: Cardiology Associates of Fairfield County, P.C., status: RECRUITING, city: Stamford, state: Connecticut, zip: 06905, country: United States, contacts name: Thomas Nero, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 41.05343, lon: -73.53873, locations facility: Chase Medical Research, LLC, status: RECRUITING, city: Waterbury, state: Connecticut, zip: 06708, country: United States, contacts name: Joseph Soufer, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 41.55815, lon: -73.0515, locations facility: MedStar Washington Hospital Center, status: NOT_YET_RECRUITING, city: Washington, state: District of Columbia, zip: 20010, country: United States, contacts name: Ron Waksman, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 38.89511, lon: -77.03637, locations facility: Excel Medical Clinical Trials, status: RECRUITING, city: Boca Raton, state: Florida, zip: 33434, country: United States, contacts name: DAVID FUNT, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 26.3669, lon: -80.13033, locations facility: Clearwater Cardiovascular & Interventional Consultants M.D., P.A., status: NOT_YET_RECRUITING, city: Clearwater, state: Florida, zip: 33756, country: United States, contacts name: Douglas J Spriggs, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 27.96585, lon: -82.8001, locations facility: Clinical Research of West Florida, Inc. (Clearwater), status: NOT_YET_RECRUITING, city: Clearwater, state: Florida, zip: 33765, country: United States, contacts name: Leonard Jay Dunn, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 27.96585, lon: -82.8001, locations facility: Elite Cardiac Research Center, status: NOT_YET_RECRUITING, city: Hialeah, state: Florida, zip: 33013, country: United States, contacts name: Manuel Bouza, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 25.8576, lon: -80.27811, locations facility: Westside Center for Clinical Research, status: RECRUITING, city: Jacksonville, state: Florida, zip: 32205, country: United States, contacts name: Albert Lopez, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 30.33218, lon: -81.65565, locations facility: Encore Research Group- Jacksonville Center for Clinical Research, status: RECRUITING, city: Jacksonville, state: Florida, zip: 32216, country: United States, contacts name: Michael Koren, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 30.33218, lon: -81.65565, locations facility: Clearwater Cardiovascular & Interventional Consultants M.D., P.A., status: NOT_YET_RECRUITING, city: Largo, state: Florida, zip: 33777, country: United States, contacts name: Syed Masood Gilani, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 27.90979, lon: -82.78842, locations facility: K2 Medical Research - Maitland, status: RECRUITING, city: Maitland, state: Florida, zip: 32751, country: United States, contacts name: Neel Patel, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 28.62778, lon: -81.36312, locations facility: South Florida Clinical Research Institute, status: RECRUITING, city: Margate, state: Florida, zip: 33063, country: United States, contacts name: Juan Loy, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 26.24453, lon: -80.20644, locations facility: Inpatient Research Clinic, status: RECRUITING, city: Miami Lakes, state: Florida, zip: 33014, country: United States, contacts name: Alexis Gutierrez, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 25.90871, lon: -80.30866, locations facility: Suncoast Research Group, status: RECRUITING, city: Miami, state: Florida, zip: 33135, country: United States, contacts name: Mark Kutner, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 25.77427, lon: -80.19366, locations facility: Advanced Research for Health Improvement, LLC, status: RECRUITING, city: Naples, state: Florida, zip: 34102, country: United States, contacts name: Julian J. Javier, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 26.14234, lon: -81.79596, locations facility: Renstar Medical Research, status: RECRUITING, city: Ocala, state: Florida, zip: 34470, country: United States, contacts name: David Lucius Oliver, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 29.1872, lon: -82.14009, locations facility: Elixia Central Florida, status: RECRUITING, city: Orlando, state: Florida, zip: 32806, country: United States, contacts name: Arvind Madan, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 28.53834, lon: -81.37924, locations facility: Florida Institute For Clinical Research, LLC, status: RECRUITING, city: Orlando, state: Florida, zip: 32825, country: United States, contacts name: Humberto Cruz, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 28.53834, lon: -81.37924, locations facility: Innovative Research Institute - Port Charlotte, status: RECRUITING, city: Port Charlotte, state: Florida, zip: 33952, country: United States, contacts name: Joseph Ravid, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 26.97617, lon: -82.09064, locations facility: Peace River Cardiovascular Center, status: RECRUITING, city: Port Charlotte, state: Florida, zip: 33952, country: United States, contacts name: David Hotchkiss, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 26.97617, lon: -82.09064, locations facility: Progressive Medical Research, status: NOT_YET_RECRUITING, city: Port Orange, state: Florida, zip: 32127, country: United States, contacts name: Richard Mohammed, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 29.13832, lon: -80.99561, locations facility: Clearwater Cardiovascular & Interventional Consultants M.D., P.A., status: NOT_YET_RECRUITING, city: Safety Harbor, state: Florida, zip: 34695, country: United States, contacts name: Kenneth C. Sabatino, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 27.99085, lon: -82.69316, locations facility: Clinical Research of West Florida, status: NOT_YET_RECRUITING, city: Tampa, state: Florida, zip: 33606, country: United States, contacts name: Lon D. Lynn, DO, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 27.94752, lon: -82.45843, locations facility: Care Access - Tampa, status: RECRUITING, city: Tampa, state: Florida, zip: 33625, country: United States, contacts name: Shital Mehta, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 27.94752, lon: -82.45843, locations facility: Cardiology Partners Clinical Research Institute - Wellington, status: NOT_YET_RECRUITING, city: Wellington, state: Florida, zip: 33449, country: United States, contacts name: Jean Foucauld, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 26.65868, lon: -80.24144, locations facility: American Clinical Trials - Acworth, status: RECRUITING, city: Acworth, state: Georgia, zip: 30101, country: United States, contacts name: CHINEDU PATRICK NWEKE, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 34.06635, lon: -84.67837, locations facility: Grady Memorial System, status: NOT_YET_RECRUITING, city: Atlanta, state: Georgia, zip: 30303, country: United States, contacts name: Jalal Ghali, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 33.749, lon: -84.38798, locations facility: Atlanta Diabetes Associates, status: NOT_YET_RECRUITING, city: Atlanta, state: Georgia, zip: 30318, country: United States, contacts name: Bruce Bode, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 33.749, lon: -84.38798, locations facility: Emory University School of Medicine, status: NOT_YET_RECRUITING, city: Atlanta, state: Georgia, zip: 30322, country: United States, contacts name: Arshed Quyyumi, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 33.749, lon: -84.38798, locations facility: Southeastern Clinical Research Institute, status: RECRUITING, city: Augusta, state: Georgia, zip: 30904, country: United States, contacts name: Barton Brezina, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 33.47097, lon: -81.97484, locations facility: East Coast Institute for Research - Canton, status: RECRUITING, city: Canton, state: Georgia, zip: 30114, country: United States, contacts name: Jason Berner, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 34.23676, lon: -84.49076, locations facility: American Clinical Trials - Douglasville, status: RECRUITING, city: Douglasville, state: Georgia, zip: 30134, country: United States, contacts name: Ayorinde Soipe, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 33.7515, lon: -84.74771, locations facility: Center for Advanced Research & Education, status: NOT_YET_RECRUITING, city: Gainesville, state: Georgia, zip: 30501, country: United States, contacts name: Angela Dawn Ritter, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 34.29788, lon: -83.82407, locations facility: Georgia Clinical Research - Lawrenceville, status: NOT_YET_RECRUITING, city: Lawrenceville, state: Georgia, zip: 30044, country: United States, contacts name: George K Rafeedie, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 33.95621, lon: -83.98796, locations facility: East Coast Institute for Research at The Jones Center, status: RECRUITING, city: Macon, state: Georgia, zip: 31210, country: United States, contacts name: Thomas Cunningham Jones, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 32.84069, lon: -83.6324, locations facility: The Queen's Medical Center, status: NOT_YET_RECRUITING, city: Honolulu, state: Hawaii, zip: 96813, country: United States, contacts name: Helaine Kwong, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 21.30694, lon: -157.85833, locations facility: Care Research, status: RECRUITING, city: Boise, state: Idaho, zip: 83704, country: United States, contacts name: David Hinchman, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 43.6135, lon: -116.20345, locations facility: Chicago Clinical Research Institute, status: NOT_YET_RECRUITING, city: Chicago, state: Illinois, zip: 60607, country: United States, contacts name: Dennis J Levinson, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 41.85003, lon: -87.65005, locations facility: Clinical Investigation Specialists, status: RECRUITING, city: Gurnee, state: Illinois, zip: 60031, country: United States, contacts name: Luis Gonzalez-Orozco, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 42.3703, lon: -87.90202, locations facility: Alliance for Multispecialty Research, LLC, status: RECRUITING, city: Park Ridge, state: Illinois, zip: 60068, country: United States, contacts name: Saifullah Nasir, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 42.01114, lon: -87.84062, locations facility: Central Illinois Diabetes and Clinical Research a Division of Prairie Education and Research Cooperative, status: RECRUITING, city: Springfield, state: Illinois, zip: 62711, country: United States, contacts name: Diana Widicus, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 39.80172, lon: -89.64371, locations facility: Accellacare - DuPage, status: NOT_YET_RECRUITING, city: Winfield, state: Illinois, zip: 60190, country: United States, contacts name: George Nijmeh, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 41.8617, lon: -88.1609, locations facility: American Health Network of IN, LLC, status: RECRUITING, city: Avon, state: Indiana, zip: 46123, country: United States, contacts name: Daniel K. Storey, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 39.76282, lon: -86.39972, locations facility: American Health Network of IN, LLC, status: NOT_YET_RECRUITING, city: Franklin, state: Indiana, zip: 46131, country: United States, contacts name: George Mitchell Cornett, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 39.48061, lon: -86.05499, locations facility: Indiana University Health Methodist Hospital, status: NOT_YET_RECRUITING, city: Indianapolis, state: Indiana, zip: 46202, country: United States, contacts name: Julie Clary, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 39.76838, lon: -86.15804, locations facility: Iowa Diabetes and Endocrinology Research Center, status: RECRUITING, city: West Des Moines, state: Iowa, zip: 50265, country: United States, contacts name: Anuj Bhargava, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 41.57721, lon: -93.71133, locations facility: Cotton O'Neil Clinical Research Center - Central Office, status: RECRUITING, city: Topeka, state: Kansas, zip: 66606, country: United States, contacts name: Michael Cox, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 39.04833, lon: -95.67804, locations facility: Qualmedica Research, status: NOT_YET_RECRUITING, city: Bowling Green, state: Kentucky, zip: 42101, country: United States, contacts name: J Christopher Sartore, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 36.99032, lon: -86.4436, locations facility: Cambridge Medical Trials, status: NOT_YET_RECRUITING, city: Alexandria, state: Louisiana, zip: 71301, country: United States, contacts name: Naseem Jaffrani, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 31.31129, lon: -92.44514, locations facility: Grace Research - Bossier, status: NOT_YET_RECRUITING, city: Bossier City, state: Louisiana, zip: 71111, country: United States, contacts name: William Britton Eaves, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 32.51599, lon: -93.73212, locations facility: Care Access - Lake Charles, status: RECRUITING, city: Lake Charles, state: Louisiana, zip: 70601, country: United States, contacts name: William Nabours, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 30.21309, lon: -93.2044, locations facility: IMA Clinical Research, status: RECRUITING, city: Monroe, state: Louisiana, zip: 71201, country: United States, contacts name: Mark C. Napoli, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 32.50931, lon: -92.1193, locations facility: Alliance for Multispecialty Research, LLC, status: RECRUITING, city: New Orleans, state: Louisiana, zip: 70119, country: United States, contacts name: Robert J Noveck, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 29.95465, lon: -90.07507, locations facility: Louisiana Heart Center - Slidell, status: RECRUITING, city: Slidell, state: Louisiana, zip: 70458, country: United States, contacts name: Marc Bernstein, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 30.27519, lon: -89.78117, locations facility: Care Access - Baltimore, status: RECRUITING, city: Baltimore, state: Maryland, zip: 21213, country: United States, contacts name: Peta-Gay Jackson Booth, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 39.29038, lon: -76.61219, locations facility: Sinai Hospital Of Baltimore, status: NOT_YET_RECRUITING, city: Baltimore, state: Maryland, zip: 21215, country: United States, contacts name: Paul Gurbel, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 39.29038, lon: -76.61219, locations facility: Maryland Cardiovascular Specialists, status: RECRUITING, city: Baltimore, state: Maryland, zip: 21229, country: United States, contacts name: Jeffrey F. Cole, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 39.29038, lon: -76.61219, locations facility: MedStar Good Samaritan Hospital, status: NOT_YET_RECRUITING, city: Baltimore, state: Maryland, zip: 21239, country: United States, contacts name: Adline Ghazi, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 39.29038, lon: -76.61219, locations facility: Jadestone Clinical Research, status: RECRUITING, city: Beltsville, state: Maryland, zip: 20705, country: United States, contacts name: Ayim Akyea-Djamson, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 39.03483, lon: -76.90747, locations facility: Flourish Research - Bowie, status: RECRUITING, city: Bowie, state: Maryland, zip: 20715, country: United States, contacts name: BARBARA ALEXANDER HUTCHINSON, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 38.94278, lon: -76.73028, locations facility: Kur Research - Columbia Medical, status: NOT_YET_RECRUITING, city: Columbia, state: Maryland, zip: 21045, country: United States, contacts name: Saba Sheikh, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 39.24038, lon: -76.83942, locations facility: Anderson Medical Research, status: RECRUITING, city: Fort Washington, state: Maryland, zip: 20744, country: United States, contacts name: Felton Anderson, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 38.70734, lon: -77.02303, locations facility: MedStar Health Research Institute (MedStar Physician Based Research Network), status: NOT_YET_RECRUITING, city: Hyattsville, state: Maryland, zip: 20782, country: United States, contacts name: Jean Park, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 38.95594, lon: -76.94553, locations facility: Brigham and Women's Hospital Diabetes Program, status: NOT_YET_RECRUITING, city: Boston, state: Massachusetts, zip: 02115, country: United States, contacts name: Vanita Aroda, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 42.35843, lon: -71.05977, locations facility: Care Access - Dorchester, status: RECRUITING, city: Dorchester, state: Massachusetts, zip: 02124, country: United States, contacts name: Anthony Eaton, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 42.29732, lon: -71.0745, locations facility: NECCR PrimaCare Research, status: RECRUITING, city: Fall River, state: Massachusetts, zip: 02721, country: United States, contacts name: Ehab Sorial, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 41.70149, lon: -71.15505, locations facility: Alliance for Multispecialty Research, LLC., status: RECRUITING, city: Dearborn, state: Michigan, zip: 48126, country: United States, contacts name: Elias H Kassab, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 42.32226, lon: -83.17631, locations facility: Revival Research Institute - Dearborn, status: RECRUITING, city: Dearborn, state: Michigan, zip: 48126, country: United States, contacts name: Qaiser Shafiq, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 42.32226, lon: -83.17631, locations facility: Arcturus Healthcare, PLC, Troy Internal Medicine Research Division, status: RECRUITING, city: Troy, state: Michigan, zip: 48098, country: United States, contacts name: Neil J. Fraser, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 42.60559, lon: -83.14993, locations facility: Michigan Heart & Vascular Institute, status: RECRUITING, city: Ypsilanti, state: Michigan, zip: 48197, country: United States, contacts name: Zakir Sahul, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 42.24115, lon: -83.61299, locations facility: The National Diabetes & Obesity Research Institute, status: NOT_YET_RECRUITING, city: Biloxi, state: Mississippi, zip: 39532, country: United States, contacts name: Stephen L. Farrow, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 30.39603, lon: -88.88531, locations facility: Medi-Lab Diagnostic, status: RECRUITING, city: Gulfport, state: Mississippi, zip: 39591, country: United States, contacts name: Stephen Boskovich, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 30.36742, lon: -89.09282, locations facility: StudyMetrix Research, status: RECRUITING, city: Saint Peters, state: Missouri, zip: 63303, country: United States, contacts name: Timothy Smith, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 38.80033, lon: -90.62651, locations facility: Mercury Street Medical Group, PLLC, status: RECRUITING, city: Butte, state: Montana, zip: 59701, country: United States, contacts name: John Pullman, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 46.00382, lon: -112.53474, locations facility: Las Vegas Endocrinology, status: NOT_YET_RECRUITING, city: Henderson, state: Nevada, zip: 89074, country: United States, contacts name: Quang T Nguyen, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 36.0397, lon: -114.98194, locations facility: DaVita Clinical Research - Las Vegas, status: RECRUITING, city: Las Vegas, state: Nevada, zip: 89107, country: United States, contacts name: MARK VISHNEPOLSKY, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 36.17497, lon: -115.13722, locations facility: Las Vegas Medical Research, status: RECRUITING, city: Las Vegas, state: Nevada, zip: 89113, country: United States, contacts name: Bharat R Mocherla, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 36.17497, lon: -115.13722, locations facility: Palm Research Center Tenaya, status: RECRUITING, city: Las Vegas, state: Nevada, zip: 89128, country: United States, contacts name: Samer Nakhle, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 36.17497, lon: -115.13722, locations facility: Internal Medicine Associates, status: RECRUITING, city: Bridgeton, state: New Jersey, zip: 08302, country: United States, contacts name: Ekram Hanna, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 39.42734, lon: -75.23408, locations facility: Cardio Metabolic Institute, status: RECRUITING, city: Somerset, state: New Jersey, zip: 08873, country: United States, contacts name: Dinesh K Singal, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 40.4976, lon: -74.48849, locations facility: Atlantic Health System Overlook Medical Center, status: RECRUITING, city: Summit, state: New Jersey, zip: 07901, country: United States, contacts name: Robert D Fishberg, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 40.71562, lon: -74.36468, locations facility: IMA Clinical Research Warren, status: RECRUITING, city: Warren, state: New Jersey, zip: 07059, country: United States, contacts name: Samar Hameed, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 40.60822, lon: -74.51803, locations facility: Golden Hearts Diagnostic, status: RECRUITING, city: Alamogordo, state: New Mexico, zip: 88310, country: United States, contacts name: Kay Banikarim, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 32.89953, lon: -105.96027, locations facility: Albuquerque Neuroscience Inc., status: RECRUITING, city: Albuquerque, state: New Mexico, zip: 87109, country: United States, contacts name: Yaw Adjei-Poku, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 35.08449, lon: -106.65114, locations facility: Albany Medical College, Division of Community Endocrinology, status: NOT_YET_RECRUITING, city: Albany, state: New York, zip: 12203, country: United States, contacts name: Robert Busch, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 42.65258, lon: -73.75623, locations facility: Marian David, MD, P.C., status: RECRUITING, city: Kew Gardens, state: New York, zip: 11415, country: United States, contacts name: Marian David, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 40.71427, lon: -73.83097, locations facility: Long Island Cardiovascular Consultants, status: RECRUITING, city: Lake Success, state: New York, zip: 11042, country: United States, contacts name: Kenneth Cohen, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 40.77066, lon: -73.71763, locations facility: NYU Langone Health, status: RECRUITING, city: New York, state: New York, zip: 10016, country: United States, contacts name: Holly Lofton, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 40.71427, lon: -74.00597, locations facility: NYU Langone Health, status: NOT_YET_RECRUITING, city: New York, state: New York, zip: 10016, country: United States, contacts name: Howard Weintraub, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 40.71427, lon: -74.00597, locations facility: Icahn School of Medicine at Mount Sinai, status: RECRUITING, city: New York, state: New York, zip: 10029, country: United States, contacts name: Robert Rosenson, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 40.71427, lon: -74.00597, locations facility: IMA Clinical Research, status: RECRUITING, city: New York, state: New York, zip: 10036, country: United States, contacts name: James Greenwald, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 40.71427, lon: -74.00597, locations facility: Lenox Hill Hospital, status: NOT_YET_RECRUITING, city: New York, state: New York, zip: 10075, country: United States, contacts name: Eugenia Gianos, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 40.71427, lon: -74.00597, locations facility: Northwell Health Physician Peconic, status: RECRUITING, city: Riverhead, state: New York, zip: 11901, country: United States, contacts name: Sean M Donahoe, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 40.91704, lon: -72.66204, locations facility: University of Rochester Medical Center, status: NOT_YET_RECRUITING, city: Rochester, state: New York, zip: 14642, country: United States, contacts name: Robert Block, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 43.15478, lon: -77.61556, locations facility: Saratoga Clinical Research, status: RECRUITING, city: Saratoga Springs, state: New York, zip: 12866, country: United States, contacts name: David Kandath, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 43.08313, lon: -73.78457, locations facility: Stony Brook University, status: NOT_YET_RECRUITING, city: Stony Brook, state: New York, zip: 11794, country: United States, contacts name: on chen, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 40.92565, lon: -73.14094, locations facility: Care Access - Fayetteville, status: RECRUITING, city: Fayetteville, state: North Carolina, zip: 28314, country: United States, contacts name: Daniel Uba, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 35.05266, lon: -78.87836, locations facility: Medication Management, status: RECRUITING, city: Greensboro, state: North Carolina, zip: 27405, country: United States, contacts name: Jagadeesh (Jay) R. Ganji, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 36.07264, lon: -79.79198, locations facility: Triad Clinical Trials, status: RECRUITING, city: Greensboro, state: North Carolina, zip: 27410, country: United States, contacts name: Richard Lewis Montgomery, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 36.07264, lon: -79.79198, locations facility: Physician's East Endocrinology, status: RECRUITING, city: Greenville, state: North Carolina, zip: 27834, country: United States, contacts name: Mark Warren, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 35.61266, lon: -77.36635, locations facility: IMA Clinical Research Mount Airy, status: RECRUITING, city: Mount Airy, state: North Carolina, zip: 27030, country: United States, contacts name: Tamas I Balogh, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 36.4993, lon: -80.60729, locations facility: Accellacare - Raleigh, status: RECRUITING, city: Raleigh, state: North Carolina, zip: 27609, country: United States, contacts name: John Rubino, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 35.7721, lon: -78.63861, locations facility: Accellacare - Wilmington, status: RECRUITING, city: Wilmington, state: North Carolina, zip: 28401, country: United States, contacts name: Matthew James Janik, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 34.22573, lon: -77.94471, locations facility: Wake Forest Baptist Health, status: NOT_YET_RECRUITING, city: Winston-Salem, state: North Carolina, zip: 27157, country: United States, contacts name: Michael Shapiro, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 36.09986, lon: -80.24422, locations facility: Rapid Medical Research, status: RECRUITING, city: Beachwood, state: Ohio, zip: 44122, country: United States, contacts name: Margaret Rhee, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 41.4645, lon: -81.50873, locations facility: Velocity Clinical Research, Mt. Auburn, status: RECRUITING, city: Cincinnati, state: Ohio, zip: 45219, country: United States, contacts name: Matthew Donald Wenker, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 39.12713, lon: -84.51435, locations facility: Velocity Clinical Research, Springdale, status: RECRUITING, city: Cincinnati, state: Ohio, zip: 45246, country: United States, contacts name: Charles H. Eger, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 39.12713, lon: -84.51435, locations facility: Cleveland Clinic, status: NOT_YET_RECRUITING, city: Cleveland, state: Ohio, zip: 44124, country: United States, contacts name: Julie Huang, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 41.4995, lon: -81.69541, locations facility: Ohio State University, status: NOT_YET_RECRUITING, city: Columbus, state: Ohio, zip: 43210, country: United States, contacts name: John Larry, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 39.96118, lon: -82.99879, locations facility: Aventiv Research Inc, status: NOT_YET_RECRUITING, city: Columbus, state: Ohio, zip: 43213, country: United States, contacts name: Sridhar Guduri, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 39.96118, lon: -82.99879, locations facility: Good Samaritan Regional Medical Center, status: NOT_YET_RECRUITING, city: Corvallis, state: Oregon, zip: 97330, country: United States, contacts name: Jeremy Warner, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 44.56457, lon: -123.26204, locations facility: Lehigh Valley Health Network, status: NOT_YET_RECRUITING, city: Allentown, state: Pennsylvania, zip: 18103, country: United States, contacts name: Andrew Sumner, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 40.60843, lon: -75.49018, locations facility: Heritage Valley Medical Group, Inc., status: RECRUITING, city: Beaver, state: Pennsylvania, zip: 15009, country: United States, contacts name: Michael J Oliver, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 40.69534, lon: -80.30478, locations facility: Capital Area Research, LLC, status: RECRUITING, city: Camp Hill, state: Pennsylvania, zip: 17011, country: United States, contacts name: Venkatesh Nadar, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 40.23981, lon: -76.91997, locations facility: Abington Medical Specialists, status: NOT_YET_RECRUITING, city: Horsham, state: Pennsylvania, zip: 19044, country: United States, contacts name: Bruce Klugherz, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 40.17844, lon: -75.12851, locations facility: Lancaster General Hospital, status: NOT_YET_RECRUITING, city: Lancaster, state: Pennsylvania, zip: 17602, country: United States, contacts name: Marjan Mujib, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 40.03788, lon: -76.30551, locations facility: Penn Medicine: University of Pennsylvania Health System, status: NOT_YET_RECRUITING, city: Philadelphia, state: Pennsylvania, zip: 19104, country: United States, contacts name: Archna Bajaj, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 39.95233, lon: -75.16379, locations facility: Clinical Research of Philadelphia, status: RECRUITING, city: Philadelphia, state: Pennsylvania, zip: 19114, country: United States, contacts name: Donna M Gavarone, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 39.95233, lon: -75.16379, locations facility: AHN Allegheny General Hospital, status: NOT_YET_RECRUITING, city: Pittsburgh, state: Pennsylvania, zip: 15212, country: United States, contacts name: Indu Poornima, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 40.44062, lon: -79.99589, locations facility: Keystone Clinical Studies, status: RECRUITING, city: Plymouth Meeting, state: Pennsylvania, zip: 19462, country: United States, contacts name: Stephen Litman, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 40.10233, lon: -75.27435, locations facility: Preferred Primary Care Physicians, status: RECRUITING, city: Uniontown, state: Pennsylvania, zip: 15401, country: United States, contacts name: Kenton Hess, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 39.90008, lon: -79.71643, locations facility: Cardiology Consultants of Philadelphia Yardley, status: RECRUITING, city: Yardley, state: Pennsylvania, zip: 19067, country: United States, contacts name: Paul Grena, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 40.24566, lon: -74.846, locations facility: Heart and Vascular Research at WellSpan Health, status: NOT_YET_RECRUITING, city: York, state: Pennsylvania, zip: 17403, country: United States, contacts name: Christopher Wenger, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 39.9626, lon: -76.72774, locations facility: Accellacare Trident Cardiology, status: RECRUITING, city: Charleston, state: South Carolina, zip: 29456, country: United States, contacts name: William D Yarbrough, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 32.77657, lon: -79.93092, locations facility: Tribe Clinical Research, LLC, status: RECRUITING, city: Greenville, state: South Carolina, zip: 29607, country: United States, contacts name: Ronald Mayfield, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 34.85262, lon: -82.39401, locations facility: Walker Family Care, status: RECRUITING, city: Little River, state: South Carolina, zip: 29566, country: United States, contacts name: Stephen Dale Grubb, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 33.87323, lon: -78.61418, locations facility: Care Access - Mauldin, status: RECRUITING, city: Mauldin, state: South Carolina, zip: 29662, country: United States, contacts name: Anne Tuggle, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 34.77873, lon: -82.31012, locations facility: Accellacare - Mt Pleasant, status: RECRUITING, city: Mount Pleasant, state: South Carolina, zip: 29464, country: United States, contacts name: Richard E. Mills, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 32.79407, lon: -79.86259, locations facility: Monument Health Rapid City Hospital, status: NOT_YET_RECRUITING, city: Rapid City, state: South Dakota, zip: 57701, country: United States, contacts name: Rajesh Pradhan, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 44.08054, lon: -103.23101, locations facility: Alliance for Multispecialty Research, LLC, status: RECRUITING, city: Knoxville, state: Tennessee, zip: 37909, country: United States, contacts name: William B. Smith, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 35.96064, lon: -83.92074, locations facility: Care Access - Memphis, status: RECRUITING, city: Memphis, state: Tennessee, zip: 38128, country: United States, contacts name: Joseph Seth Weinstein, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 35.14953, lon: -90.04898, locations facility: PharmaTex Research, status: RECRUITING, city: Amarillo, state: Texas, zip: 79109, country: United States, contacts name: David Brabham, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 35.222, lon: -101.8313, locations facility: Amarillo Heart Clinical Research Institute Inc., status: RECRUITING, city: Amarillo, state: Texas, zip: 79124, country: United States, contacts name: Joaquin Martinez Arraras, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 35.222, lon: -101.8313, locations facility: IMA Clinical Research Austin, status: RECRUITING, city: Austin, state: Texas, zip: 78745, country: United States, contacts name: Nomita Kim, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 30.26715, lon: -97.74306, locations facility: Velocity Clinical Research, Austin, status: RECRUITING, city: Austin, state: Texas, zip: 78759, country: United States, contacts name: Michael Patrick Zimmerman, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 30.26715, lon: -97.74306, locations facility: Headlands Research - Brownsville, status: RECRUITING, city: Brownsville, state: Texas, zip: 78526, country: United States, contacts name: Christopher Romero, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 25.90175, lon: -97.49748, locations facility: South Texas Clinical Research, status: RECRUITING, city: Corpus Christi, state: Texas, zip: 78404, country: United States, contacts name: Travis Taylor, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 27.80058, lon: -97.39638, locations facility: Private Practice - Dr. James E. Race, status: RECRUITING, city: Dallas, state: Texas, zip: 75224, country: United States, contacts name: James E Race, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 32.78306, lon: -96.80667, locations facility: Baylor Soltero CV Research Center, status: NOT_YET_RECRUITING, city: Dallas, state: Texas, zip: 75226, country: United States, contacts name: Cara East, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 32.78306, lon: -96.80667, locations facility: Zenos Clinical Research, status: RECRUITING, city: Dallas, state: Texas, zip: 75230, country: United States, contacts name: James Lilly, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 32.78306, lon: -96.80667, locations facility: Cedar Health Research, status: RECRUITING, city: Dallas, state: Texas, zip: 75251, country: United States, contacts name: Michele Reynolds, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 32.78306, lon: -96.80667, locations facility: UT Southwestern Medical Center, status: NOT_YET_RECRUITING, city: Dallas, state: Texas, zip: 75390, country: United States, contacts name: Parag Joshi, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 32.78306, lon: -96.80667, locations facility: Cardio Voyage, status: RECRUITING, city: Denison, state: Texas, zip: 75020, country: United States, contacts name: Wael Abo-Auda, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 33.75566, lon: -96.53666, locations facility: South Texas Research Institute, status: NOT_YET_RECRUITING, city: Edinburg, state: Texas, zip: 78539, country: United States, contacts name: Rashmee Patil, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 26.30174, lon: -98.16334, locations facility: Texas Health Research & Education Institute - Fort Worth, status: NOT_YET_RECRUITING, city: Fort Worth, state: Texas, zip: 76104, country: United States, contacts name: Tyler Bloomer, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 32.72541, lon: -97.32085, locations facility: Center for Cardiometabolic Disease Prevention/Baylor College of Medicine, status: RECRUITING, city: Houston, state: Texas, zip: 77030, country: United States, contacts name: Christie Mitchell Ballantyne, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 29.76328, lon: -95.36327, locations facility: Juno Research, status: RECRUITING, city: Houston, state: Texas, zip: 77040, country: United States, contacts name: Damaris Vega, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 29.76328, lon: -95.36327, locations facility: Endocrine Ips, Pllc, status: NOT_YET_RECRUITING, city: Houston, state: Texas, zip: 77079, country: United States, contacts name: Amer S Al-Karadsheh, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 29.76328, lon: -95.36327, locations facility: Amir A Hassan, MD, PA, status: NOT_YET_RECRUITING, city: Houston, state: Texas, zip: 77089, country: United States, contacts name: Amir Ali Hassan, MD, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 29.76328, lon: -95.36327, locations facility: Accurate Clinical Research, Inc, status: NOT_YET_RECRUITING, city: Humble, state: Texas, zip: 77338, country: United States, contacts name: Nilay Mehta, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 29.99883, lon: -95.26216, locations facility: The Heart Institute of East Texas, status: RECRUITING, city: Lufkin, state: Texas, zip: 75904, country: United States, contacts name: Ravinder Bachireddy, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 31.33824, lon: -94.7291, locations facility: Biopharma Informatic, LLC, status: RECRUITING, city: McAllen, state: Texas, zip: 78503, country: United States, contacts name: Christian Assad-Kottner, MD, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 26.20341, lon: -98.23001, locations facility: Wellness Clinical Research, status: NOT_YET_RECRUITING, city: McKinney, state: Texas, zip: 75069, country: United States, contacts name: Zahid Zafar, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 33.19762, lon: -96.61527, locations facility: North Texas Research Associates, status: RECRUITING, city: McKinney, state: Texas, zip: 75071, country: United States, contacts name: Faizan Iftikhar, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 33.19762, lon: -96.61527, locations facility: Texas Institute of Cardiology, PA, status: RECRUITING, city: McKinney, state: Texas, zip: 75071, country: United States, contacts name: Faisal Wahid, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 33.19762, lon: -96.61527, locations facility: PRX Research, status: RECRUITING, city: Mesquite, state: Texas, zip: 75149, country: United States, contacts name: Urooj Shibli, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 32.7668, lon: -96.59916, locations facility: Southern Endocrinology Associates, status: RECRUITING, city: Mesquite, state: Texas, zip: 75149, country: United States, contacts name: Sumana Gangi, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 32.7668, lon: -96.59916, locations facility: Clinical Advancement Center, status: NOT_YET_RECRUITING, city: San Antonio, state: Texas, zip: 78212, country: United States, contacts name: Pablo E Pergola, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 29.42412, lon: -98.49363, locations facility: Clinical Trials of Texas, Inc., status: RECRUITING, city: San Antonio, state: Texas, zip: 78229, country: United States, contacts name: Douglas Denham, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 29.42412, lon: -98.49363, locations facility: Diagnostics Research Group, status: RECRUITING, city: San Antonio, state: Texas, zip: 78229, country: United States, contacts name: Lisa J Blair, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 29.42412, lon: -98.49363, locations facility: Endeavor Clinical Trials, status: RECRUITING, city: San Antonio, state: Texas, zip: 78240, country: United States, contacts name: Nitendra Agarwal, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 29.42412, lon: -98.49363, locations facility: Consano Clinical Research, LLC, status: RECRUITING, city: Shavano Park, state: Texas, zip: 78231, country: United States, contacts name: JohnMichelle Welch, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 29.58495, lon: -98.55252, locations facility: DaVita Clinical Research - North Houston, status: RECRUITING, city: Shenandoah, state: Texas, zip: 77384, country: United States, contacts name: Adam Immanuel Frome, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 30.18022, lon: -95.45577, locations facility: Revival Research Institute - Sherman, status: RECRUITING, city: Sherman, state: Texas, zip: 75092, country: United States, contacts name: Asad Karim, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 33.63566, lon: -96.60888, locations facility: Sherman Clinical Research, status: RECRUITING, city: Sherman, state: Texas, zip: 75092, country: United States, contacts name: Nikhil Joshi, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 33.63566, lon: -96.60888, locations facility: Alpine Research Organization, status: RECRUITING, city: Clinton, state: Utah, zip: 84015, country: United States, contacts name: Justin Mansfield, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 41.13967, lon: -112.0505, locations facility: Intermountain Medical Center, status: NOT_YET_RECRUITING, city: Murray, state: Utah, zip: 84107, country: United States, contacts name: Jeffrey Anderson, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 40.66689, lon: -111.88799, locations facility: Virginia Heart, status: RECRUITING, city: Falls Church, state: Virginia, zip: 22042, country: United States, contacts name: Tariq Haddad, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 38.88233, lon: -77.17109, locations facility: Alliance for Multispecialty Research, LLC, status: RECRUITING, city: Norfolk, state: Virginia, zip: 23502, country: United States, contacts name: Mary C. L. Bailey, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 36.84681, lon: -76.28522, locations facility: Eastside Research Associates, status: RECRUITING, city: Redmond, state: Washington, zip: 98052, country: United States, contacts name: Kevin Michael Hanson, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 47.67399, lon: -122.12151, locations facility: Exemplar Research, status: RECRUITING, city: Morgantown, state: West Virginia, zip: 26505, country: United States, contacts name: WARD J PAINE, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 39.62953, lon: -79.9559, locations facility: Clinical Investigation Specialists, status: RECRUITING, city: Kenosha, state: Wisconsin, zip: 53144, country: United States, contacts name: John M Agaiby, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 42.58474, lon: -87.82119, locations facility: CEDIC, status: RECRUITING, city: Caba, state: Buenos Aires, zip: C1060ABN, country: Argentina, contacts name: Elizabeth Gelersztein, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -34.61315, lon: -58.37723, locations facility: Consultorio Medico Dr Litvak Bruno, status: RECRUITING, city: Ciudad Autonoma de Buenos Aires, state: Buenos Aires, zip: 1406, country: Argentina, contacts name: MARCOS RAUL LITVAK BRUNO, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -34.61315, lon: -58.37723, locations facility: Centro de Investigaciones Metabólicas (CINME), status: NOT_YET_RECRUITING, city: Ciudad Autónoma de Buenos Aires, state: Buenos Aires, zip: C1027AAP, country: Argentina, contacts name: Federico Perez Manghi, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -34.61315, lon: -58.37723, locations facility: IDIM - Instituto de Diagnóstico e Investigaciones Metabólicas, status: RECRUITING, city: Ciudad de Buenos Aires, state: Buenos Aires, zip: C1012AAR, country: Argentina, contacts name: Mariela Veronica Bazan, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -34.61315, lon: -58.37723, locations facility: MICA - Medicina e Investigación Cardiometabólica, status: NOT_YET_RECRUITING, city: Del Viso, state: Buenos Aires, zip: 1669, country: Argentina, contacts name: Micaela Mirada, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -34.45082, lon: -58.79769, locations facility: Hospital Italiano de La Plata, status: NOT_YET_RECRUITING, city: La Plata, state: Buenos Aires, zip: 1900, country: Argentina, contacts name: Luis Cartasegna, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -34.92145, lon: -57.95453, locations facility: CIMeL Clinical Research, status: NOT_YET_RECRUITING, city: Lanus, state: Buenos Aires, zip: B1824KAJ, country: Argentina, contacts name: Mariano Chahin, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -34.70252, lon: -58.3955, locations facility: Centro de Investigaciones Médicas Mar del Plata, status: NOT_YET_RECRUITING, city: Mar del Plata, state: Buenos Aires, zip: 7600, country: Argentina, contacts name: Alejandro Pereyra, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -38.00228, lon: -57.55754, locations facility: Instituto de Investigaciones Clínicas Mar del Plata, status: NOT_YET_RECRUITING, city: Mar del Plata, state: Buenos Aires, zip: B7600FZO, country: Argentina, contacts name: Sergio Andres Nemi, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -38.00228, lon: -57.55754, locations facility: Clínica Privada Independencia, status: NOT_YET_RECRUITING, city: Munro, state: Buenos Aires, zip: 1605, country: Argentina, contacts name: Maan Sarem, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -34.53021, lon: -58.52421, locations facility: Instituto De Investigaciones Clinicas Quilmes, status: NOT_YET_RECRUITING, city: Quilmes, state: Buenos Aires, zip: 1878, country: Argentina, contacts name: Adrian Hrabar, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -34.72904, lon: -58.26374, locations facility: DIM Clínica Privada, status: NOT_YET_RECRUITING, city: Ramos Mejía, state: Buenos Aires, zip: B1704ETD, country: Argentina, contacts name: Oscar Montaña, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -34.6551, lon: -58.55318, locations facility: Corporación Médica San Martín, status: NOT_YET_RECRUITING, city: San Martín, state: Buenos Aires, zip: 1650, country: Argentina, contacts name: Fernando Guardiani, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -33.08103, lon: -68.46814, locations facility: Go Centro Medico San Nicolás, status: NOT_YET_RECRUITING, city: San Nicolas, state: Buenos Aires, zip: 2900, country: Argentina, contacts name: Paulina Lanchiotti, role: PRINCIPAL_INVESTIGATOR, locations facility: Stat Research S.A., status: RECRUITING, city: Buenos Aires, state: Ciudad Autónoma De Buenos Aires, zip: C1023AAB, country: Argentina, contacts name: Lucas Lisandro Gutnisky, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -34.61315, lon: -58.37723, locations facility: Investigaciones Medicas Imoba Srl, status: NOT_YET_RECRUITING, city: Buenos Aires, state: Ciudad Autónoma De Buenos Aires, zip: C1056ABH, country: Argentina, contacts name: Jose Maria Pedro Soler, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -34.61315, lon: -58.37723, locations facility: CIPREC, status: RECRUITING, city: Buenos Aires, state: Ciudad Autónoma De Buenos Aires, zip: C1061AAS, country: Argentina, contacts name: Fernando Guerlloy, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -34.61315, lon: -58.37723, locations facility: Fundación favaloro para la Docencia e Investigación Médica, status: NOT_YET_RECRUITING, city: Buenos Aires, state: Ciudad Autónoma De Buenos Aires, zip: C1093AAS, country: Argentina, contacts name: Gustavo Ariel Giunta, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -34.61315, lon: -58.37723, locations facility: CIPREC, status: NOT_YET_RECRUITING, city: Buenos Aires, state: Ciudad Autónoma De Buenos Aires, zip: C1119ACN, country: Argentina, contacts name: Angela Romero Zarante, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -34.61315, lon: -58.37723, locations facility: Glenny Corp, status: RECRUITING, city: Buenos Aires, state: Ciudad Autónoma De Buenos Aires, zip: C1430CKE, country: Argentina, contacts name: Martin Koretzky, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -34.61315, lon: -58.37723, locations facility: Clinica Adventista Belgrano, status: RECRUITING, city: Caba, state: Ciudad Autónoma De Buenos Aires, zip: C1430EGF, country: Argentina, contacts name: Marcelo Martín casas, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -34.61315, lon: -58.37723, locations facility: Centro Medico Dra. Laura Maffei- Investigacion Clinica Aplicada, status: RECRUITING, city: Ciudad Autonoma de Buenos Aires, state: Ciudad Autónoma De Buenos Aires, zip: C1425AGC, country: Argentina, contacts name: Emilio Daniel Alaguibe, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -34.61315, lon: -58.37723, locations facility: Clínica Privada del Prado SRL, status: NOT_YET_RECRUITING, city: Alberdi, state: Córdoba, zip: 5000, country: Argentina, contacts name: Maria Alejandra Gutierrez, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -32.88987, lon: -60.69058, locations facility: Instituto Médico Río Cuarto, status: NOT_YET_RECRUITING, city: Río Cuarto, state: Córdoba, zip: X5800AEV, country: Argentina, contacts name: Osvaldo Magri, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -33.13067, lon: -64.34992, locations facility: Centro Privado de Medicina Respiratoria, status: RECRUITING, city: Paraná, state: Entre Ríos, zip: 3100, country: Argentina, contacts name: Luis Darío Larrateguy, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -31.73197, lon: -60.5238, locations facility: CIPADI - Centro Integral de Prevencion y Atencion en Diabetes, status: RECRUITING, city: Godoy Cruz, state: Mendoza, zip: 5501, country: Argentina, contacts name: Pedro Rosario Fabian Calella, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -32.92863, lon: -68.8351, locations facility: Centro de Investigaciones Clínicas Baigorria, status: RECRUITING, city: Granadero Baigorria, state: Santa Fe, zip: 2152, country: Argentina, contacts name: Juan Escalante, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -32.85683, lon: -60.71754, locations facility: Fundacion Estudios Clinicos, status: NOT_YET_RECRUITING, city: Rosario, state: Santa Fe, zip: 2000, country: Argentina, contacts name: María Schiavoni, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -32.94682, lon: -60.63932, locations facility: INECO Neurociencias Oroño, status: NOT_YET_RECRUITING, city: Rosario, state: Santa Fe, zip: 2000, country: Argentina, contacts name: Dana Miralles, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -32.94682, lon: -60.63932, locations facility: Instituto de Especialidades de la Salud Rosario, status: NOT_YET_RECRUITING, city: Rosario, state: Santa Fe, zip: 2000, country: Argentina, contacts name: Ana Elisa Chiesa, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -32.94682, lon: -60.63932, locations facility: Instituto Médico Catamarca IMEC, status: RECRUITING, city: Rosario, state: Santa Fe, zip: 2000, country: Argentina, contacts name: Natacha Maldonado, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -32.94682, lon: -60.63932, locations facility: Instituto Médico Fundación Grupo Colaborativo Rosario Investigación y Prevención Medica, status: RECRUITING, city: Rosario, state: Santa Fe, zip: 2000, country: Argentina, contacts name: Horacio Angel Sessa, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -32.94682, lon: -60.63932, locations facility: Instituto de Investigaciones Clinicas Rosario, status: NOT_YET_RECRUITING, city: Rosario, state: Santa Fe, zip: S2000CVD, country: Argentina, contacts name: Carolina Chacón, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -32.94682, lon: -60.63932, locations facility: Laboratorio de Hemostasia y Trombosis, status: RECRUITING, city: Rosario, state: Santa Fe, zip: S2000DTB, country: Argentina, contacts name: Vanina Gorosito, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -32.94682, lon: -60.63932, locations facility: Hospital Provincial del Centenario, status: NOT_YET_RECRUITING, city: Rosario, state: Santa Fe, zip: S2002KDS, country: Argentina, contacts name: Martin Najenson, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -32.94682, lon: -60.63932, locations facility: Sanatorio San Martin, status: NOT_YET_RECRUITING, city: Venado Tuerto, state: Santa Fe, zip: 2600, country: Argentina, contacts name: Oscar Gomez Vilamajo, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -33.74556, lon: -61.96885, locations facility: Centro Modelo de Cardiología, status: RECRUITING, city: San Miguel de Tucuman, state: Tucumán, zip: 4000, country: Argentina, contacts name: GUILLERMO MERCAU, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -26.82414, lon: -65.2226, locations facility: Clínica Mayo de Urgencias Médicas Cruz Blanca S.R.L, status: RECRUITING, city: San Miguel de Tucuman, state: Tucumán, zip: 4000, country: Argentina, contacts name: Maria Mansilla, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -26.82414, lon: -65.2226, locations facility: Investigaciones Clínicas Tucumán, status: RECRUITING, city: San Miguel de Tucuman, state: Tucumán, zip: 4000, country: Argentina, contacts name: ALDO PRADO, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -26.82414, lon: -65.2226, locations facility: Buenos Aires Macula S.A, status: NOT_YET_RECRUITING, city: Buenos Aires, zip: 1061, country: Argentina, contacts name: Augusto Lavalle Cobo, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -34.61315, lon: -58.37723, locations facility: Instituto Médico Especializado (IME), status: NOT_YET_RECRUITING, city: Buenos Aires, zip: 1405, country: Argentina, contacts name: Gabriela Laura Rossi, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -34.61315, lon: -58.37723, locations facility: Consultorio Medico Investigador Principal Dr Besada, status: NOT_YET_RECRUITING, city: Buenos Aires, zip: 1426, country: Argentina, contacts name: Diego Alejandro Besada, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -34.61315, lon: -58.37723, locations facility: Instituto Cardiovascular de Buenos Aires, status: NOT_YET_RECRUITING, city: Buenos Aires, zip: 1428, country: Argentina, contacts name: Fernando Osvaldo Botto, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -34.61315, lon: -58.37723, locations facility: CEMEDIC, status: RECRUITING, city: Buenos Aires, zip: C1407GTN, country: Argentina, contacts name: Claudio Majul, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -34.61315, lon: -58.37723, locations facility: Fundación Respirar, status: RECRUITING, city: Buenos Aires, zip: C1426ABP, country: Argentina, contacts name: Marina Uhrig, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -34.61315, lon: -58.37723, locations facility: Instituto de Cardiología "Juana F. Cabral", status: RECRUITING, city: Corrientes, zip: 3400, country: Argentina, contacts name: Julio Andres Vallejos, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -27.4806, lon: -58.8341, locations facility: Instituto de Investigaciones Clínicas Córdoba, status: NOT_YET_RECRUITING, city: Córdoba, zip: 5000, country: Argentina, contacts name: Ines Bartolacci, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -31.4135, lon: -64.18105, locations facility: Sanatorio Privado Duarte Quirós, status: NOT_YET_RECRUITING, city: Córdoba, zip: 5002, country: Argentina, contacts name: Hugo Raul Colombo, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -31.4135, lon: -64.18105, locations facility: Centro Médico Colón, status: NOT_YET_RECRUITING, city: Córdoba, zip: 5003, country: Argentina, contacts name: Maria Parody, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -31.4135, lon: -64.18105, locations facility: Instituto de Cardiología Wolff, status: RECRUITING, city: Mendoza, zip: 5500, country: Argentina, contacts 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contacts name: Miguel Hominal, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -31.63333, lon: -60.7, locations facility: Paratus Clinical Research Canberra, status: RECRUITING, city: Bruce, state: Australian Capital Territory, zip: 2617, country: Australia, contacts name: Amber Leah, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -32.46667, lon: 138.2, locations facility: Paratus Clinical Research Western Sydney, status: RECRUITING, city: Blacktown, state: New South Wales, zip: 2148, country: Australia, contacts name: Fiona Napier-Flood, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -33.76667, lon: 150.91667, locations facility: Optimus Clinical Research, status: RECRUITING, city: Botany, state: New South Wales, zip: 2019, country: Australia, contacts name: Paul Bird, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -33.94599, lon: 151.19591, locations facility: Northern Beaches Clinical Research, status: RECRUITING, city: Brookvale, state: New South Wales, zip: 2100, country: Australia, contacts name: Richard de Solom, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -33.76108, lon: 151.27446, locations facility: Paratus Clinical Research Central Coast, status: RECRUITING, city: Kanwal, state: New South Wales, zip: 2259, country: Australia, contacts name: Dominic Douglas, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -33.253, lon: 151.4911, locations facility: Liverpool Hospital, status: NOT_YET_RECRUITING, city: Liverpool, state: New South Wales, zip: 2170, country: Australia, contacts name: Christian Mussap, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -33.90011, lon: 150.93328, locations facility: The AIM Centre / Hunter Diabetes Centre, status: RECRUITING, city: Merewether, state: New South Wales, zip: 2291, country: Australia, contacts name: Claire Morbey, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -32.94801, lon: 151.74325, locations facility: AusTrials - St. Leonards, status: RECRUITING, city: Sydney, state: New South Wales, zip: 2065, country: Australia, contacts name: (Alexander) Munro Neville, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -33.86785, lon: 151.20732, locations facility: Royal Brisbane and Women's Hospital, status: NOT_YET_RECRUITING, city: Brisbane, state: Queensland, zip: 4029, country: Australia, contacts name: CHRISTOPHER HAMMETT, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -27.46794, lon: 153.02809, locations facility: Core Research Group, status: RECRUITING, city: Brisbane, state: Queensland, zip: 4064, country: Australia, contacts name: David Martin Colquhoun, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -27.46794, lon: 153.02809, locations facility: Heart of Australia, status: RECRUITING, city: Brisbane, state: Queensland, zip: 4068, country: Australia, contacts name: Rolf Gomes, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -27.46794, lon: 153.02809, locations facility: Cholesterol Care, status: RECRUITING, city: Brisbane, state: Queensland, zip: 4102, country: Australia, contacts name: Karam Kostner, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -27.46794, lon: 153.02809, locations facility: Paratus Clinical Research Brisbane, status: RECRUITING, city: Herston, state: Queensland, zip: 4010, country: Australia, contacts name: Pi Lip Seet, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -27.44453, lon: 153.01852, locations facility: Logan Hospital, status: NOT_YET_RECRUITING, city: Meadowbrook, state: Queensland, zip: 4131, country: Australia, contacts name: Gaurav Puri, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -27.66401, lon: 153.14465, locations facility: Mount Isa Base Hospital, status: NOT_YET_RECRUITING, city: Mount Isa, state: Queensland, zip: 4825, country: Australia, contacts name: Anudeep K Gupta, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -20.72523, lon: 139.49727, locations facility: The Townsville Hospital, status: RECRUITING, city: Townsville, state: Queensland, zip: 4814, country: Australia, contacts name: Anudeep K Gupta, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -19.26639, lon: 146.80569, locations facility: Fusion Clinical Research, status: RECRUITING, city: Adelaide, state: South Australia, zip: 5000, country: Australia, contacts name: Christopher Demarquay Rook, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -34.92866, lon: 138.59863, locations facility: Nightingale Research, status: RECRUITING, city: Adelaide, state: South Australia, zip: 5000, country: Australia, contacts name: Andrew Hamilton, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -34.92866, lon: 138.59863, locations facility: Adelaide Cardiology, status: RECRUITING, city: Adelaide, state: South Australia, zip: 5068, country: Australia, contacts name: Jamie Morton, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -34.92866, lon: 138.59863, locations facility: Emeritus Research, status: RECRUITING, city: Camberwell, state: Victoria, zip: 3124, country: Australia, contacts name: Stuart Game, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -37.84205, lon: 145.0694, locations facility: Victorian Heart Hospital, status: NOT_YET_RECRUITING, city: Clayton, state: Victoria, zip: 3168, country: Australia, contacts name: Stephen Nicholls, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -37.91667, lon: 145.11667, locations facility: Barwon Health, status: RECRUITING, city: Geelong, state: Victoria, zip: 3220, country: Australia, contacts name: John Amerena, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -38.14711, lon: 144.36069, locations facility: Austin Health - Repatriation Hospital, status: RECRUITING, city: Heidelberg West, state: Victoria, zip: 3081, country: Australia, contacts name: Elif Ekinci, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -37.75, lon: 145.03333, locations facility: AusTrials - Sunshine, status: RECRUITING, city: Melbourne, state: Victoria, zip: 3021, country: Australia, contacts name: Ranjit Samuel Roy Rasalam, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -37.814, lon: 144.96332, locations facility: Advara HeartCare - Mulgrave, status: RECRUITING, city: Mulgrave, state: Victoria, zip: 3170, country: Australia, contacts name: Piyush M Srivastava, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -37.91667, lon: 145.2, locations facility: GenesisCare, status: RECRUITING, city: Joondalup, state: Western Australia, zip: 6027, country: Australia, contacts name: Peter Walter Purnell, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -31.74445, lon: 115.76835, locations facility: Clinitrials, status: RECRUITING, city: Perth, state: Western Australia, zip: 6000, country: Australia, contacts name: Chris John Judkins, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -31.95224, lon: 115.8614, locations facility: Landesklinikum Mistelbach, status: NOT_YET_RECRUITING, city: Mistelbach, state: Niederösterreich, zip: 2130, country: Austria, contacts name: Thomas Gremmel, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 48.57, lon: 16.57667, locations facility: Universitätsklinikum St. Pölten, status: NOT_YET_RECRUITING, city: St. Polten, state: Niederösterreich, zip: 3100, country: Austria, contacts name: Martin Wiesholzer, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 48.2, lon: 15.63333, locations facility: Krankenhaus St. Josef Braunau, status: NOT_YET_RECRUITING, city: Braunau, state: Oberösterreich, zip: 5280, country: Austria, contacts name: Johann Auer, role: PRINCIPAL_INVESTIGATOR, locations facility: Ordensklinikum Linz GmbH Elisabethinen, status: NOT_YET_RECRUITING, city: Linz, state: Oberösterreich, zip: 4020, country: Austria, contacts name: Martin Martinek, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 48.30639, lon: 14.28611, locations facility: Konventhospital der Barmherzigen Brüder Linz, status: NOT_YET_RECRUITING, city: Linz, state: Oberösterreich, zip: 4021, country: Austria, contacts name: Martin Clodi, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 48.30639, lon: 14.28611, locations facility: Medizinische Universitaet Innsbruck, status: NOT_YET_RECRUITING, city: Innsbruck, state: Tirol, zip: 6020, country: Austria, contacts name: Susanne Kaser, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 47.26266, lon: 11.39454, locations facility: VIVIT, status: NOT_YET_RECRUITING, city: Feldkirch, state: Vorarlberg, zip: 6800, country: Austria, contacts name: Alexander Vonbank, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 47.23306, lon: 9.6, locations facility: Zentrum für klinische Studien Dr Hanusch Gmbh, status: NOT_YET_RECRUITING, city: Vienna, state: Wien, zip: 1060, country: Austria, contacts name: Ursula Hanusch, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 48.20849, lon: 16.37208, locations facility: Medizinische Universität Wien, status: NOT_YET_RECRUITING, city: Vienna, state: Wien, zip: 1090, country: Austria, contacts name: Walter Speidl, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 48.20849, lon: 16.37208, locations facility: Medizinische Universität Wien, status: NOT_YET_RECRUITING, city: Vienna, state: Wien, zip: 1090, country: Austria, contacts name: Alexandra Kautzky-Willer, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 48.20849, lon: 16.37208, locations facility: Herz Zentrum Währing - Innere Medizin und Kardiologie | Alle Kassen und Privat, status: NOT_YET_RECRUITING, city: Vienna, state: Wien, zip: 1180, country: Austria, contacts name: Georg Goliasch, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 48.20849, lon: 16.37208, locations facility: Uniklinikum Salzburg, status: NOT_YET_RECRUITING, city: Salzburg, zip: 5020, country: Austria, contacts name: Moritz Mirna, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 47.79941, lon: 13.04399, locations facility: Klinik Landstraße, status: NOT_YET_RECRUITING, city: Wien, zip: 1030, country: Austria, contacts name: Bernhard Ludvik, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 48.20849, lon: 16.37208, locations facility: Klinik Hietzing, status: NOT_YET_RECRUITING, city: Wien, zip: 1130, country: Austria, contacts name: Thomas Stulnig, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 48.20849, lon: 16.37208, locations facility: Klinik Floridsdorf, status: NOT_YET_RECRUITING, city: Wien, zip: 1210, country: Austria, contacts name: Andreas Schober, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 48.20849, lon: 16.37208, locations facility: ZNA Middelheim, status: NOT_YET_RECRUITING, city: Antwerp, state: Antwerpen, zip: 2020, country: Belgium, contacts name: Gaëlle Vermeersch, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 51.21989, lon: 4.40346, locations facility: Imelda General Hospital, status: NOT_YET_RECRUITING, city: Bonheiden, state: Antwerpen, zip: 2820, country: Belgium, contacts name: Chris Vercammen, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 51.02261, lon: 4.54714, locations facility: Algemeen Ziekenhuis klina, status: NOT_YET_RECRUITING, city: Brasschaat, state: Antwerpen, zip: 2930, country: Belgium, contacts name: Frank Cools, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 51.2912, lon: 4.49182, locations facility: Antwerp University Hospital, status: NOT_YET_RECRUITING, city: Edegem, state: Antwerpen, zip: 2650, country: Belgium, contacts name: Steven Haine, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 51.15662, lon: 4.44504, locations facility: AZ Sint-Maarten, Campus Leopoldstraat 2, status: NOT_YET_RECRUITING, city: Mechelen, state: Antwerpen, zip: 2800, country: Belgium, contacts name: Geert Vervoort, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 51.02574, lon: 4.47762, locations facility: Centre Hospitalier Universitaire Brugmann, status: NOT_YET_RECRUITING, city: Brussels, state: Bruxelles-Capitale, Région De, zip: 1020, country: Belgium, contacts name: Jose Castro SIP, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 50.85045, lon: 4.34878, locations facility: Université Libre de Bruxelles - Hôpital Erasme, status: NOT_YET_RECRUITING, city: Brussels, state: Bruxelles-Capitale, Région De, zip: 1070, country: Belgium, contacts name: Philippe van de Borne, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 50.85045, lon: 4.34878, locations facility: Cliniques universitaires Saint-Luc, status: NOT_YET_RECRUITING, city: Brussels, state: Bruxelles-Capitale, Région De, zip: 1200, country: Belgium, contacts name: Christophe Beauloye, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 50.85045, lon: 4.34878, locations facility: Grand Hôpital de Charleroi, status: NOT_YET_RECRUITING, city: Gilly, state: Hainaut, zip: 6060, country: Belgium, contacts name: Elena PENCU, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 50.42449, lon: 4.4789, locations facility: Ziekenhuis Oost-Limburg, Campus St.-Jan, status: NOT_YET_RECRUITING, city: Genk, state: Limburg, zip: 3600, country: Belgium, contacts name: David Verhaert, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 50.965, lon: 5.50082, locations facility: Jessa Ziekenhuis, status: NOT_YET_RECRUITING, city: Hasselt, state: Limburg, zip: 3500, country: Belgium, contacts name: Jan Verwerft, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 50.93106, lon: 5.33781, locations facility: AZ Sint-Blasius, status: NOT_YET_RECRUITING, city: Dendermonde, state: Oost-Vlaanderen, zip: 9200, country: Belgium, contacts name: Tom Sarens, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 51.02869, lon: 4.10106, locations facility: AZ Maria Middelares, status: NOT_YET_RECRUITING, city: Gent, state: Oost-Vlaanderen, zip: 9000, country: Belgium, contacts name: Johan De Sutter, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 51.05, lon: 3.71667, locations facility: UZ Gent, status: NOT_YET_RECRUITING, city: Gent, state: Oost-Vlaanderen, zip: 9000, country: Belgium, contacts name: Ernst Rietzschel, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 51.05, lon: 3.71667, locations facility: UZ Leuven, status: NOT_YET_RECRUITING, city: Leuven, state: Vlaams-Brabant, zip: 3000, country: Belgium, contacts name: Ann Mertens, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 50.87959, lon: 4.70093, locations facility: AZ Groeninge Campus Kennedylaan, status: NOT_YET_RECRUITING, city: Kortrijk, state: West-Vlaanderen, zip: 8500, country: Belgium, contacts name: Ivan Elegeert, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 50.82803, lon: 3.26487, locations facility: Az Damiaan vzw, status: NOT_YET_RECRUITING, city: Oostende, state: West-Vlaanderen, zip: 8400, country: Belgium, contacts name: Tim De Meyer, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 51.21551, lon: 2.927, locations facility: Centro de Pesquisas Clínicas Dr. Marco Mota, status: NOT_YET_RECRUITING, city: Maceio, state: Alagoas, zip: 57051-160, country: Brazil, contacts name: Marco Antonio Mota Gomes, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -9.66583, lon: -35.73528, locations facility: Instituto D'Or de Pesquisa e Ensino (IDOR) - Filial Salvador, status: NOT_YET_RECRUITING, city: Salvador, state: Bahia, zip: 40170-130, country: Brazil, contacts name: Luiz Eduardo Ritt, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -12.97111, lon: -38.51083, locations facility: Hospital Ana Nery (HAN) - Salvador, status: NOT_YET_RECRUITING, city: Salvador, state: Bahia, zip: 40320-010, country: Brazil, contacts name: Fernanda Pinheiro Martin Tapioca, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -12.97111, lon: -38.51083, locations facility: Hospital Da Bahia, status: NOT_YET_RECRUITING, city: Salvador, state: Bahia, zip: 41810-011, country: Brazil, contacts name: Marianna Dracoulakis, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -12.97111, lon: -38.51083, locations facility: Instituto D'Or de Pesquisa e Ensino (IDOR) - Filial Brasília, status: NOT_YET_RECRUITING, city: Brasilia, state: Distrito Federal, zip: 70390-140, country: Brazil, contacts name: Antonio Aurelio de Paiva Fagundes Junior, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -15.77972, lon: -47.92972, locations facility: Hospital Brasilia, status: NOT_YET_RECRUITING, city: Brasilia, state: Distrito Federal, zip: 71681-603, country: Brazil, contacts name: Sergio Ramalho, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -15.77972, lon: -47.92972, locations facility: L2IP - Instituto de Pesquisas Clínicas - FC072920211954380192, status: NOT_YET_RECRUITING, city: Brasília, state: Distrito Federal, zip: 70200730, country: Brazil, contacts name: Eduardo Freire Vasconcellos, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -15.77972, lon: -47.92972, locations facility: Chronos Pesquisa Clínica, status: NOT_YET_RECRUITING, city: Brasília, state: Distrito Federal, zip: 72145-450, country: Brazil, contacts name: Suzara Lopes, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -15.77972, lon: -47.92972, locations facility: CEDOES, status: NOT_YET_RECRUITING, city: Vitória, state: Espírito Santo, zip: 29055450, country: Brazil, contacts name: RACHEL ARMANI, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -20.31944, lon: -40.33778, locations facility: Universidade Federal de Goias, status: NOT_YET_RECRUITING, city: Goiania, state: Goiás, zip: 74605-020, country: Brazil, contacts name: Aguinaldo Freitas, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -16.67861, lon: -49.25389, locations facility: Hospital São Domingos, status: NOT_YET_RECRUITING, city: Bequimao, state: Maranhão, zip: 65060-645, country: Brazil, contacts name: Jose Figueiredo Neto, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -2.44889, lon: -44.7825, locations facility: Santa Casa de Misericordia de Belo Horizonte, status: NOT_YET_RECRUITING, city: Belo Horizonte, state: Minas Gerais, zip: 30150-221, country: Brazil, contacts name: Samantha Perez, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -19.92083, lon: -43.93778, locations facility: Consultoria em Controle de Infecção Hospitalar, status: NOT_YET_RECRUITING, city: Belo Horizonte, state: Minas Gerais, zip: 30150-320, country: Brazil, contacts name: Flávia Coimbra Maia, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -19.92083, lon: -43.93778, locations facility: NUPEC - Cardio, status: NOT_YET_RECRUITING, city: Belo Horizonte, state: Minas Gerais, zip: 30220-140, country: Brazil, contacts name: Fernando Carvalho Neuenschwander, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -19.92083, lon: -43.93778, locations facility: Eurolatino Pesquisas Medicas, status: NOT_YET_RECRUITING, city: Uberlandia, state: Minas Gerais, zip: 38400-500, country: Brazil, contacts name: Flavia Bittar Britto Arantes, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -18.91861, lon: -48.27722, locations facility: Pesquisa Clínica em Diabetes - Dra Rosângela Réa, status: NOT_YET_RECRUITING, city: Curitiba, state: Paraná, zip: 80040-110, country: Brazil, contacts name: Rodrigo Julio Cerci, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -25.42778, lon: -49.27306, locations facility: PUC Trials- Nucleo de Pesquisa clinica da Escola de Medicina da PUCPR, status: NOT_YET_RECRUITING, city: Curitiba, state: Paraná, zip: 80230-130, country: Brazil, contacts name: Jose Augusto Ribas Fortes, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -25.42778, lon: -49.27306, locations facility: Nucleo De Pesquisa Clinica, status: NOT_YET_RECRUITING, city: Curitiba, state: Paraná, zip: 80370-150, country: Brazil, contacts name: Paulo Roberto Rossi, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -25.42778, lon: -49.27306, locations facility: Hospital Universitário João de Barros Barreto, status: NOT_YET_RECRUITING, city: Belem, state: Pará, zip: 66073-000, country: Brazil, contacts name: Joao Felicio, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -1.45583, lon: -48.50444, locations facility: Instituto D'Or de Pesquisa e Ensino (IDOR) - Filial Pernambuco, status: NOT_YET_RECRUITING, city: Recife, state: Pernambuco, zip: 50070-480, country: Brazil, contacts name: Carlos Eduardo Montenegro, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -8.05389, lon: -34.88111, locations facility: CHN - Complexo Hospitalar de Niterói, status: NOT_YET_RECRUITING, city: Niteroi, state: Rio De Janeiro, zip: 24020-096, country: Brazil, contacts name: WOLNEY MARTINS, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -22.88333, lon: -43.10361, locations facility: Instituto Méderi de Pesquisa e Saúde, status: NOT_YET_RECRUITING, city: Passo Fundo, state: Rio Grande Do Sul, zip: 99010-120, country: Brazil, contacts name: Luciano Backes, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -28.26278, lon: -52.40667, locations facility: Hospital de Clinicas de Porto Alegre, status: NOT_YET_RECRUITING, city: Porto Alegre, state: Rio Grande Do Sul, zip: 90035-903, country: Brazil, contacts name: Adamastor Pereira, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -30.03306, lon: -51.23, locations facility: Hospital Moinhos de Vento, status: NOT_YET_RECRUITING, city: Porto Alegre, state: Rio Grande Do Sul, zip: 90035001, country: Brazil, contacts name: Debora Hoffmann Loro, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -30.03306, lon: -51.23, locations facility: Núcleo de Pesquisa Clínica do Rio Grande do Sul, status: NOT_YET_RECRUITING, city: Porto Alegre, state: Rio Grande Do Sul, zip: 90430-001, country: Brazil, contacts name: Luis Henrique Canani, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -30.03306, lon: -51.23, locations facility: Hospital São Lucas da PUCRS, status: NOT_YET_RECRUITING, city: Porto Alegre, state: Rio Grande Do Sul, zip: 90610000, country: Brazil, contacts name: Paulo Ricardo Avancini Caramori, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -30.03306, lon: -51.23, locations facility: Hospital Nossa Senhora da Conceição, status: NOT_YET_RECRUITING, city: Porto Alegre, state: Rio Grande Do Sul, zip: 91350-280, country: Brazil, contacts name: Pedro Filho, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -30.03306, lon: -51.23, locations facility: AngioCor Blumenau, status: NOT_YET_RECRUITING, city: Blumenau, state: Santa Catarina, zip: 89020-430, country: Brazil, contacts name: Adrian Kormann, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -26.91944, lon: -49.06611, locations facility: Centro de Pesquisa Clinica do Coracao, status: NOT_YET_RECRUITING, city: Aracaju, state: Sergipe, zip: 49055-530, country: Brazil, contacts name: FÁBIO SILVEIRA, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -10.91111, lon: -37.07167, locations facility: Centro de Pesquisa Sao Lucas, status: NOT_YET_RECRUITING, city: Campinas, state: São Paulo, zip: 13060-803, country: Brazil, contacts name: Aloisio Marchi Rocha, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -22.90556, lon: -47.06083, locations facility: Instituto Do Coracao De Marilia, status: NOT_YET_RECRUITING, city: Marilia, state: São Paulo, zip: 17515-000, country: Brazil, contacts name: Raphael Silva, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -22.21389, lon: -49.94583, locations facility: CAPED Centro Avancado Pesquisa e Diagnostica, status: NOT_YET_RECRUITING, city: Ribeirao Preto, state: São Paulo, zip: 14026-020, country: Brazil, contacts name: Pedro Vellosa Schwartzmann, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -21.1775, lon: -47.81028, locations facility: Faculdade de Medicina do ABC, status: NOT_YET_RECRUITING, city: Santo Andre, state: São Paulo, zip: 09060-870, country: Brazil, contacts name: Augusto Cezar Santomauro Junior, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -23.66389, lon: -46.53833, locations facility: Praxis Pesquisa Medica, status: NOT_YET_RECRUITING, city: Santo Andre, state: São Paulo, zip: 09790790, country: Brazil, contacts name: Marcelo Bacci, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -23.66389, lon: -46.53833, locations facility: Centro Multidisciplinar de Estudos Clinicos, status: NOT_YET_RECRUITING, city: Sao Bernardo do Campo, state: São Paulo, zip: 09715-090, country: Brazil, contacts name: Joao Antonio Correa, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -23.69389, lon: -46.565, locations facility: CPCLIN, status: NOT_YET_RECRUITING, city: Sao Paulo, state: São Paulo, zip: 01228-200, country: Brazil, contacts name: Denise Franco, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -23.5475, lon: -46.63611, locations facility: Hospital Alemao Oswaldo Cruz, status: NOT_YET_RECRUITING, city: Sao Paulo, state: São Paulo, zip: 01323-903, country: Brazil, contacts name: Rafael Belo Nunes, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -23.5475, lon: -46.63611, locations facility: Incor - Instituto do Coracao, status: NOT_YET_RECRUITING, city: Sao Paulo, state: São Paulo, zip: 05403-900, country: Brazil, contacts name: Raul Santos, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -23.5475, lon: -46.63611, locations facility: Fundação Faculdade Regional de Medicina de São José do Rio Preto, status: NOT_YET_RECRUITING, city: São José do Rio Preto, state: São Paulo, zip: 15090000, country: Brazil, contacts name: Lilia Maia, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -20.81972, lon: -49.37944, locations facility: Centro Internacional de Pesquisa Clínica (CIPES), status: NOT_YET_RECRUITING, city: São José dos Campos, state: São Paulo, zip: 12230-001, country: Brazil, contacts name: Fabiana Marcondes-Braga, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -23.17944, lon: -45.88694, locations facility: Instituto de Molestias Cardiovasculares de Tatui, status: NOT_YET_RECRUITING, city: Tatui, state: São Paulo, zip: 18270-170, country: Brazil, contacts name: Wladimir Saporito, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -23.35556, lon: -47.85694, locations facility: Integral Pesquisa e Ensino, status: NOT_YET_RECRUITING, city: Votuporanga, state: São Paulo, zip: 15501-405, country: Brazil, contacts name: Mauro Esteves Hernandes, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -20.42278, lon: -49.97278, locations facility: Instituto Aramari Apo, status: NOT_YET_RECRUITING, city: Asa Norte, zip: 70712-903, country: Brazil, contacts name: Luiz Sergio Fernandes de Carvalho, role: PRINCIPAL_INVESTIGATOR, locations facility: IBPClin - Instituto Brasil de Pesquisa Clínica, status: NOT_YET_RECRUITING, city: Rio de Janeiro, zip: 20241-180, country: Brazil, contacts name: Luis Augusto Tavares Russo, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -22.90278, lon: -43.2075, locations facility: Hospital São Lucas Copacabana, status: NOT_YET_RECRUITING, city: Rio de Janeiro, zip: 22061-080, country: Brazil, contacts name: Bruno Paolino, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -22.90278, lon: -43.2075, locations facility: Hospital Pro-Cardiaco, status: NOT_YET_RECRUITING, city: Rio de Janeiro, zip: 22280-003, country: Brazil, contacts name: Diane Avila, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -22.90278, lon: -43.2075, locations facility: Instituto D'Or Pesquisa e Ensino, status: NOT_YET_RECRUITING, city: Rio de Janeiro, zip: 22281-100, country: Brazil, contacts name: Denilson Campos de Albuquerque, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -22.90278, lon: -43.2075, locations facility: CPQuali Pesquisa Clínica, status: NOT_YET_RECRUITING, city: São Paulo, zip: 01228-000, country: Brazil, contacts name: Camila Canteiro Leanca, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -23.5475, lon: -46.63611, locations facility: Hospital BP, status: NOT_YET_RECRUITING, city: São Paulo, zip: 01321-001, country: Brazil, contacts name: Fernando Faglioni Ribas, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -23.5475, lon: -46.63611, locations facility: Hospital 9 De Julho, status: NOT_YET_RECRUITING, city: São Paulo, zip: 01409-001, country: Brazil, contacts name: Eduardo Lima, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -23.5475, lon: -46.63611, locations facility: Hospital do Coracao, status: NOT_YET_RECRUITING, city: São Paulo, zip: 04003-905, country: Brazil, contacts name: Lucas Tramujas, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -23.5475, lon: -46.63611, locations facility: Instituto Dante Pazzanese de Cardiology, status: NOT_YET_RECRUITING, city: São Paulo, zip: 04012-909, country: Brazil, contacts name: Andre Faludi, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -23.5475, lon: -46.63611, locations facility: Núcleo de Pesquisa Clínica da Rede São Camilo, status: NOT_YET_RECRUITING, city: São Paulo, zip: 04014-002, country: Brazil, contacts name: Luana Casari da Silva Lima, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -23.5475, lon: -46.63611, locations facility: CEPIC - Centro Paulista de Investigação Clínica, status: RECRUITING, city: São Paulo, zip: 04266-010, country: Brazil, contacts name: Breno Balabem Alves, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -23.5475, lon: -46.63611, locations facility: Fraser Clinical Trials Inc, status: NOT_YET_RECRUITING, city: New Westminster, state: British Columbia, zip: V3L 3W4, country: Canada, contacts name: Razi Khan, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 49.20678, lon: -122.91092, locations facility: SMH Cardiology Clinical Trials, status: RECRUITING, city: Surrey, state: British Columbia, zip: V3V 0C6, country: Canada, contacts name: Peter Tan, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 49.10635, lon: -122.82509, locations facility: The Medical Arts Health Research Group, status: RECRUITING, city: Vancouver, state: British Columbia, zip: V7M 2H4, country: Canada, contacts name: John Vyselaar, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 49.24966, lon: -123.11934, locations facility: Victoria Heart Institute Foundation, status: RECRUITING, city: Victoria, state: British Columbia, zip: V8R 1B2, country: Canada, contacts name: Christopher Franco, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 48.43294, lon: -123.3693, locations facility: Discovery Clinical Services, status: RECRUITING, city: Victoria, state: British Columbia, zip: V8T 5G4, country: Canada, contacts name: Gordon Hoag, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 48.43294, lon: -123.3693, locations facility: Winnipeg Clinic, status: RECRUITING, city: Winnipeg, state: Manitoba, zip: R3C 0N2, country: Canada, contacts name: Vincent Woo, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 49.8844, lon: -97.14704, locations facility: G A Research Associates, status: RECRUITING, city: Moncton, state: New Brunswick, zip: E1G 1A7, country: Canada, contacts name: Jocelyn Cormier, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 46.09454, lon: -64.7965, locations facility: Care Access - Cape Breton, status: RECRUITING, city: Sydney, state: Nova Scotia, zip: B1M 0A1, country: Canada, contacts name: Paul MacDonald, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 46.13511, lon: -60.1831, locations facility: Cardio Health Clinical Trial - Brampton, status: RECRUITING, city: Brampton, state: Ontario, zip: L6Y 6H4, country: Canada, contacts name: Gary Maur, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 43.68341, lon: -79.76633, locations facility: Hamilton Medical Research Group, status: RECRUITING, city: Hamilton, state: Ontario, zip: L8M 1K7, country: Canada, contacts name: Richard Tytus, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 43.25011, lon: -79.84963, locations facility: Cardio Health Clinical Trial - London, status: RECRUITING, city: London, state: Ontario, zip: N6H 5L4, country: Canada, contacts name: Zahid Sardar, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 42.98339, lon: -81.23304, locations facility: North York Diagnostic and Cardiac Centre, status: RECRUITING, city: North York, state: Ontario, zip: M6B 3H7, country: Canada, contacts name: Subodh Verma, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 43.76681, lon: -79.4163, locations facility: Oakville Cardiovascular Research LP, status: RECRUITING, city: Oakville, state: Ontario, zip: L6K 3W7, country: Canada, contacts name: Sean Jedrzkiewicz, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 43.45011, lon: -79.68292, locations facility: Cardio Health Clinical Trial - St. Thomas, status: RECRUITING, city: St. Thomas, state: Ontario, zip: N5R 2R4, country: Canada, contacts name: Zahid Sardar, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 42.77361, lon: -81.18038, locations facility: Corcare, status: RECRUITING, city: Toronto, state: Ontario, zip: M1B 5N1, country: Canada, contacts name: Paul Galiwango, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 43.70011, lon: -79.4163, locations facility: Diabetes Heart Research Centre, status: RECRUITING, city: Toronto, state: Ontario, zip: M6G 1M2, country: Canada, contacts name: Luis Noronha, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 43.70011, lon: -79.4163, locations facility: Ecogene-21, status: RECRUITING, city: Chicoutimi, state: Quebec, zip: G7H 7K9, country: Canada, contacts name: Daniel Gaudet, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 48.41963, lon: -71.06369, locations facility: Viacar Recherche Clinique, status: RECRUITING, city: Greenfield Park, state: Quebec, zip: J4V 2G8, country: Canada, contacts name: Raja RECHERCHES Chehayeb, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 45.48649, lon: -73.46223, locations facility: Clinique des Maladies Lipidiques de Québec, status: RECRUITING, city: Québec, state: Quebec, zip: G1V 4W2, country: Canada, contacts name: Jean Bergeron, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 46.81228, lon: -71.21454, locations facility: Diex Recherche Joliette, status: RECRUITING, city: Saint-Charles-Borromée, state: Quebec, zip: J6E 2B4, country: Canada, contacts name: Laurence Laplante, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 46.05007, lon: -73.46586, locations facility: Unité de Recherche Clinique du CISSS des Laurentides, status: NOT_YET_RECRUITING, city: St-Jerome, state: Quebec, zip: J7Z 2V4, country: Canada, contacts name: Yves Pesant, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 45.78036, lon: -74.00365, locations facility: Centre de Medecine Metabolique de Lanaudiere (CMML), status: RECRUITING, city: Terrebonne, state: Quebec, zip: J6X 4P7, country: Canada, contacts name: Yves Robitaille, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 45.70004, lon: -73.64732, locations facility: Diex Recherche Trois-Rivieres, status: RECRUITING, city: Trois-Rivieres, state: Quebec, zip: G9A 4P3, country: Canada, contacts name: Ying Tung Sia, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 46.34515, lon: -72.5477, locations facility: The Second People's Hospital of Hefei, status: NOT_YET_RECRUITING, city: Hefei, state: Anhui, zip: 230011, country: China, contacts name: Jun Ye, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 31.86389, lon: 117.28083, locations facility: Anhui Provincil Hospital South District, status: NOT_YET_RECRUITING, city: Hefei, state: Anhui, zip: 230036, country: China, contacts name: Likun Ma, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 31.86389, lon: 117.28083, locations facility: Wannan Medical College Yijishan Hospital, status: NOT_YET_RECRUITING, city: Wuhu, state: Anhui, zip: 241001, country: China, contacts name: Yueyun Chen, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 31.33728, lon: 118.37351, locations facility: Beijing ChaoYang Hospital, status: NOT_YET_RECRUITING, city: Beijing, state: Beijing, zip: 100020, country: China, contacts name: Mulei Chen, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 39.9075, lon: 116.39723, locations facility: Beijing Friendship Hospital, status: NOT_YET_RECRUITING, city: Beijing, state: Beijing, zip: 100050, country: China, contacts name: Mingxia Yuan, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 39.9075, lon: 116.39723, locations facility: Peking University Third Hospital, status: NOT_YET_RECRUITING, city: Beijing, state: Beijing, zip: 100091, country: China, contacts name: Ming Cui, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 39.9075, lon: 116.39723, locations facility: 2nd Affiliated Hospital Chongqing Medical Universi, status: NOT_YET_RECRUITING, city: Chongqing, state: Chongqing, zip: 400000, country: China, contacts name: ZHIYU LING, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 29.56278, lon: 106.55278, locations facility: Chongqing Three Gorges Central Hospital, status: NOT_YET_RECRUITING, city: Wanzhou, state: Chongqing, zip: 404199, country: China, contacts name: Huaming Mou, role: PRINCIPAL_INVESTIGATOR, locations facility: Xiamen Cardiovascular Hospital, status: NOT_YET_RECRUITING, city: Xiamen, state: Fujian, zip: 361006, country: China, contacts name: Cuilian Dai, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 24.47979, lon: 118.08187, locations facility: The First Hospital of Lanzhou University, status: NOT_YET_RECRUITING, city: Lanzhou, state: Gansu, zip: 730000, country: China, contacts name: Zheng Zhang, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 36.05701, lon: 103.83987, locations facility: Lanzhou university second hospital, status: NOT_YET_RECRUITING, city: Lanzhou, state: Gansu, zip: 730030, country: China, contacts name: Xiaowei Zhang, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 36.05701, lon: 103.83987, locations facility: Shunde Hospital of Southern Medical Univesity, status: NOT_YET_RECRUITING, city: Foshan, state: Guangdong, zip: 528399, country: China, contacts name: Yuli Huang, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 23.02677, lon: 113.13148, locations facility: Guangdong Provincial People's Hospital, status: NOT_YET_RECRUITING, city: Guangzhou, state: Guangdong, zip: 510000, country: China, contacts name: Jiyan Chen, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 23.11667, lon: 113.25, locations facility: Guangzhou First People's Hospital, status: NOT_YET_RECRUITING, city: Guangzhou, state: Guangdong, zip: 510180, country: China, contacts name: Jian Liu, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 23.11667, lon: 113.25, locations facility: The First Affiliated Hospital, Sun Yat-sen University, status: NOT_YET_RECRUITING, city: Guangzhou, state: Guangdong, country: China, contacts name: Yugang Dong, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 23.11667, lon: 113.25, locations facility: Huizhou Municipal Central Hospital, status: NOT_YET_RECRUITING, city: Huizhou, state: Guangdong, zip: 516001, country: China, contacts name: Xiongwei XIE, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 23.11147, lon: 114.41523, locations facility: Shenzhen Sun Yat-sen Cardiovascular Hospital, status: NOT_YET_RECRUITING, city: Shenzhen, state: Guangdong, zip: 518057, country: China, contacts name: Xin Zheng, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 22.54554, lon: 114.0683, locations facility: Guangxi People's Hospital, status: NOT_YET_RECRUITING, city: Nanning, state: Guangxi, zip: 530021, country: China, contacts name: Qingwei Ji, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 22.81667, lon: 108.31667, locations facility: The First Hospital of Harbin Medical University, status: NOT_YET_RECRUITING, city: Harbin, state: Heilongjiang, zip: 150001, country: China, contacts name: Yue Li, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 45.75, lon: 126.65, locations facility: The Fourth Hospital of Harbin Medical University, status: NOT_YET_RECRUITING, city: Harbin, state: Heilongjiang, zip: 150001, country: China, contacts name: ZhiFeng Cheng, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 45.75, lon: 126.65, locations facility: The First Affiliated Hospital of Henan University of Science &Technology, status: NOT_YET_RECRUITING, city: Luoyang, state: Henan, zip: 471003, country: China, contacts name: Hongwei Jiang, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 34.68361, lon: 112.45361, locations facility: The First Affiliated Hospital of Henan University of Science &Technology, status: NOT_YET_RECRUITING, city: Luoyang, state: Henan, zip: 471003, country: China, contacts name: Zhijuan Li, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 34.68361, lon: 112.45361, locations facility: The First Affiliated Hospital of Nanyang Medical College, status: NOT_YET_RECRUITING, city: Nanyang, state: Henan, zip: 473007, country: China, contacts name: Dexue Liu, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 32.99472, lon: 112.53278, locations facility: The First Affiliated Hospital of Nanyang Medical College, status: NOT_YET_RECRUITING, city: Nanyang, state: Henan, country: China, contacts name: Jie Li, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 32.99472, lon: 112.53278, locations facility: The Second Affiliated Hospital of Zhengzhou University, status: NOT_YET_RECRUITING, city: Zhengzhou, state: Henan, zip: 450014, country: China, contacts name: Qingju Li, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 34.75778, lon: 113.64861, locations facility: Jingzhou Central Hospital, status: NOT_YET_RECRUITING, city: Jingzhou, state: Hubei, zip: 434020, country: China, contacts name: Keping Yang, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 30.35028, lon: 112.19028, locations facility: Wuhan University Medical College - Hubei Zhongshan Hospital, status: NOT_YET_RECRUITING, city: Wuhan, state: Hubei, zip: 430000, country: China, contacts name: Jingyi Zhang, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 30.58333, lon: 114.26667, locations facility: Wuhan Asia Heart Hospital, status: NOT_YET_RECRUITING, city: Wuhan, state: Hubei, zip: 430022, country: China, contacts name: Hua Yan, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 30.58333, lon: 114.26667, locations facility: Renmin Hospital of Wuhan University, status: NOT_YET_RECRUITING, city: Wuhan, state: Hubei, zip: 430060, country: China, contacts name: Xuejun Jiang, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 30.58333, lon: 114.26667, locations facility: Changde First People's Hospital, status: NOT_YET_RECRUITING, city: Changde, state: Hunan, zip: 415000, country: China, contacts name: Liangqing GE, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 29.04638, lon: 111.6783, locations facility: The Third Xiangya Hospital of Central South University, status: NOT_YET_RECRUITING, city: Changsha, state: Hunan, zip: 410013, country: China, contacts name: Weihong Jiang, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 28.19874, lon: 112.97087, locations facility: The First People's Hospital of Yueyang, status: NOT_YET_RECRUITING, city: Yueyang, state: Hunan, zip: 414000, country: China, contacts name: Gang Pan, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 29.37455, lon: 113.09481, locations facility: Chifeng Hospital, status: NOT_YET_RECRUITING, city: Chifeng, state: Inner Mongolia, zip: 024099, country: China, contacts name: XIANDONG SUN, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 42.26833, lon: 118.96361, locations facility: Inner Mongolia People's Hospital, status: NOT_YET_RECRUITING, city: Hohhot, state: Inner Mongolia, zip: 010017, country: China, contacts name: Liping He, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 40.81056, lon: 111.65222, locations facility: Changzhou Second People's Hospital, status: NOT_YET_RECRUITING, city: Changzhou, state: Jiangsu, zip: 213000, country: China, contacts name: Yuan Ji, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 31.77359, lon: 119.95401, locations facility: Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School, status: NOT_YET_RECRUITING, city: Nanjing, state: Jiangsu, zip: 210000, country: China, contacts name: Biao Xu, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 32.06167, lon: 118.77778, locations facility: Zhongda Hospital Southeast University, status: NOT_YET_RECRUITING, city: Nanjing, state: Jiangsu, zip: 210009, country: China, contacts name: Genshan Ma, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 32.06167, lon: 118.77778, locations facility: The Second Affiliated Hospital of Nanjing Medical University, status: NOT_YET_RECRUITING, city: Nanjing, state: Jiangsu, zip: 210011, country: China, contacts name: Yibing Lu, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 32.06167, lon: 118.77778, locations facility: The Second Affiliated Hospital of Nanjing Medical University, status: NOT_YET_RECRUITING, city: Nanjing, state: Jiangsu, zip: 210011, country: China, contacts name: Mingzhi Long, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 32.06167, lon: 118.77778, locations facility: Jiangsu Province Hospital, status: NOT_YET_RECRUITING, city: Nanjing, state: Jiangsu, zip: 210029, country: China, contacts name: Dianfu Li, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 32.06167, lon: 118.77778, locations facility: Wuxi People's Hospital, status: NOT_YET_RECRUITING, city: Wuxi, state: Jiangsu, zip: 214023, country: China, contacts name: Ruxing Wang, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 31.56887, lon: 120.28857, locations facility: The Affiliated Hospital of Xuzhou Medical College, status: NOT_YET_RECRUITING, city: Xuzhou, state: Jiangsu, zip: 221006, country: China, contacts name: Hong Zhu, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 34.18045, lon: 117.15707, locations facility: The Second Affiliated Hospital of Nanchang University, status: NOT_YET_RECRUITING, city: Nanchang, state: Jiangxi, zip: 330006, country: China, contacts name: Yanqing Wu, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 28.68396, lon: 115.85306, locations facility: The Third Hospital of Nanchang, status: NOT_YET_RECRUITING, city: Nanchang, state: Jiangxi, zip: 330009, country: China, contacts name: Zhaohui Pei, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 28.68396, lon: 115.85306, locations facility: The First Hospital of Jilin University, status: NOT_YET_RECRUITING, city: Changchun, state: Jilin, zip: 100012, country: China, contacts name: Qian Tong, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 43.88, lon: 125.32278, locations facility: China-Japan Union Hospital, status: NOT_YET_RECRUITING, city: Changchun, state: Jilin, zip: 130033, country: China, contacts name: Yuquan He, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 43.88, lon: 125.32278, locations facility: Siping Central People's Hospital, status: NOT_YET_RECRUITING, city: Siping, state: Jilin, zip: 136000, country: China, contacts name: Zhihua Fang, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 43.16143, lon: 124.37785, locations facility: Dalian Municipal Central Hospital Affiliated of Dalian Medical University, status: NOT_YET_RECRUITING, city: Dalian, state: Liaoning, zip: 116033, country: China, contacts name: Xiaoqun Zheng, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 38.91222, lon: 121.60222, locations facility: The People's Hospital of Liaoning Province, status: NOT_YET_RECRUITING, city: Shenyang, state: Liaoning, zip: 110000, country: China, contacts name: Aijie Hou, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 41.79222, lon: 123.43278, locations facility: Tangdu Hospital of Fourth Military Medical University of Chinese People's Liberation Army, status: NOT_YET_RECRUITING, city: Xi'an, state: Shaanxi, zip: 710038, country: China, contacts name: Yan Li, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 34.25833, lon: 108.92861, locations facility: The First Affiliated Hospital of Xi'an Jiaotong University, status: NOT_YET_RECRUITING, city: Xi'an, state: Shaanxi, zip: 710061, country: China, contacts name: Zuyi Yuan, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 34.25833, lon: 108.92861, locations facility: Shaanxi provincial people's hospital, status: NOT_YET_RECRUITING, city: Xian, state: Shaanxi, zip: 710068, country: China, contacts name: Junkui Wang, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 34.25833, lon: 108.92861, locations facility: Jinan Central Hospital, status: NOT_YET_RECRUITING, city: Jinan, state: Shandong, zip: 250013, country: China, contacts name: GuoHai Su, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 36.66833, lon: 116.99722, locations facility: Jinan Central Hospital, status: NOT_YET_RECRUITING, city: Jinan, state: Shandong, zip: 250013, country: China, contacts name: Xiaolin Dong, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 36.66833, lon: 116.99722, locations facility: Jining Medical University - Affiliated Hospital, status: NOT_YET_RECRUITING, city: Jining, state: Shandong, zip: 272029, country: China, contacts name: jinguo zhang, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 35.405, lon: 116.58139, locations facility: Zhongshan Hospital,Fudan University, status: NOT_YET_RECRUITING, city: Shanghai, state: Shanghai, zip: 200032, country: China, contacts name: Wang Zhen, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 31.22222, lon: 121.45806, locations facility: West China Hospital, Sichuan University, status: NOT_YET_RECRUITING, city: Cheng Du, state: Sichuan, zip: 610041, country: China, contacts name: Yong He, role: PRINCIPAL_INVESTIGATOR, locations facility: Sichuan Provincial People's Hospital, status: NOT_YET_RECRUITING, city: Chengdu, state: Sichuan, zip: 610072, country: China, contacts name: Jianhong Tao, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 30.66667, lon: 104.06667, locations facility: TEDA International Cardiovascular Hospital, status: NOT_YET_RECRUITING, city: Tianjin, state: Tianjin, zip: 300457, country: China, contacts name: Jian Zhang, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 39.14222, lon: 117.17667, locations facility: Tianjin Fourth Centre Hospital, status: NOT_YET_RECRUITING, city: Tianjin, state: Tianjin, zip: Tianjin, country: China, contacts name: Xiaochun Xing, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 39.14222, lon: 117.17667, locations facility: The First Affiliated Hospital of Xinjiang Medical University, status: NOT_YET_RECRUITING, city: Urumchi, state: Xinjiang, zip: 830054, country: China, contacts name: Xiang Ma, role: PRINCIPAL_INVESTIGATOR, locations facility: People's Hospital of Xinjiang Uygur Autonomous Region, status: NOT_YET_RECRUITING, city: Urumqi, state: Xinjiang, zip: 830001, country: China, contacts name: Hui Peng, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 43.80096, lon: 87.60046, locations facility: Sir Run Run Shaw Hospital, status: NOT_YET_RECRUITING, city: Hangzhou, state: Zhejiang, zip: 310016, country: China, contacts name: Guosheng Fu, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 30.29365, lon: 120.16142, locations facility: Lishui Central Hospital, status: NOT_YET_RECRUITING, city: Lishui City, state: Zhejiang, country: China, contacts name: Lingchun Lv, role: PRINCIPAL_INVESTIGATOR, locations facility: Ningbo First Hospital, status: NOT_YET_RECRUITING, city: Ningbo, state: Zhejiang, zip: 315010, country: China, contacts name: Xiaohong Fei, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 29.87819, lon: 121.54945, locations facility: The First Affiliated Hospital of Wenzhou Medical University, status: NOT_YET_RECRUITING, city: Wenzhou, state: Zhejiang, zip: 325000, country: China, contacts name: Hao Zhou, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 27.99942, lon: 120.66682, locations facility: Shanghai East Hospital, status: NOT_YET_RECRUITING, city: Shanghai, zip: 200120, country: China, contacts name: Ying Li, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 31.22222, lon: 121.45806, locations facility: General Hospital of Ningxia Medical University, status: NOT_YET_RECRUITING, city: Yinchuan, zip: 750004, country: China, contacts name: xueping Ma, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 38.46806, lon: 106.27306, locations facility: Kardiologická ambulance Brno, status: NOT_YET_RECRUITING, city: Brno, state: Brno-město, zip: 612 00, country: Czechia, contacts name: Jiri Parenica, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 49.19522, lon: 16.60796, locations facility: EFERTUS healthcare s.r.o., status: NOT_YET_RECRUITING, city: Brno, state: Brno-město, zip: 635 00, country: Czechia, contacts name: Hana Matejovska, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 49.19522, lon: 16.60796, locations facility: Vojenská Nemocnice Brno, status: NOT_YET_RECRUITING, city: Brno, state: Brno-město, zip: 636 00, country: Czechia, contacts name: Stanislav Mihola, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 49.19522, lon: 16.60796, locations facility: Fakultni Nemocnice u sv. Anny v Brne, status: NOT_YET_RECRUITING, city: Brno, state: Brno-město, zip: 656 91, country: Czechia, contacts name: Robert Prosecky, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 49.19522, lon: 16.60796, locations facility: Fakultni Nemocnice u sv. Anny v Brne, status: NOT_YET_RECRUITING, city: Brno, state: Jihomoravský Kraj, zip: 60200, country: Czechia, contacts name: Vladimir Kincl, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 49.19522, lon: 16.60796, locations facility: EDUMED - Náchod, status: NOT_YET_RECRUITING, city: Nachod, state: Královéhradecký Kraj, zip: 547 01, country: Czechia, contacts name: Alica Vesela, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 50.4167, lon: 16.16289, locations facility: Kardiologicka ambulance, status: NOT_YET_RECRUITING, city: Litovel, state: Olomoucký Kraj, zip: 784 01, country: Czechia, contacts name: Petra Maskova, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 49.70121, lon: 17.07615, locations facility: Agentura Science Pro, status: NOT_YET_RECRUITING, city: Olomouc, state: Olomoucký Kraj, zip: 779 00, country: Czechia, contacts name: Tomas Brychta, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 49.59552, lon: 17.25175, locations facility: Kardiologicka a Angiologicka Ambulance, status: NOT_YET_RECRUITING, city: Ostrava, state: Ostrava Město, zip: 700 30, country: Czechia, contacts name: Dusan Kucera, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 49.83465, lon: 18.28204, locations facility: Private Practice - Dr. Miroslav Koliba, status: NOT_YET_RECRUITING, city: Ostrava, state: Ostrava Město, zip: 702 00, country: Czechia, contacts name: Miroslav Koliba, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 49.83465, lon: 18.28204, locations facility: Angiocentrum Komorany, status: NOT_YET_RECRUITING, city: Prague, state: Praha 12, zip: 143 00, country: Czechia, contacts name: Ales Horacek, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 50.08804, lon: 14.42076, locations facility: Poliklinika Lípa Centrum, status: NOT_YET_RECRUITING, city: Prague, state: Praha 13, zip: 158 00, country: Czechia, contacts name: Eva Zidkova, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 50.08804, lon: 14.42076, locations facility: Synexus Czech, status: NOT_YET_RECRUITING, city: Prague, state: Praha 2, zip: 120 00, country: Czechia, contacts name: Katarina Halciakova, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 50.08804, lon: 14.42076, locations facility: Nefrologie, status: NOT_YET_RECRUITING, city: Prague, state: Praha 4, zip: 149 00, country: Czechia, contacts name: Lucie Hornova, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 50.08804, lon: 14.42076, locations facility: DiaVize s.r.o., status: NOT_YET_RECRUITING, city: Praha, state: Praha 4, zip: 140 00, country: Czechia, contacts name: Marta Klementova, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 50.08804, lon: 14.42076, locations facility: Centrum Kardiovaskularni Mediciny, status: NOT_YET_RECRUITING, city: Prague, state: Praha 6, zip: 169 00, country: Czechia, contacts name: Jean-Claude Lubanda, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 50.08804, lon: 14.42076, locations facility: Kardio Uhrineves, status: NOT_YET_RECRUITING, city: Prague, state: Praha, Hlavní Mešto, zip: 104 00, country: Czechia, contacts name: Marian Levcik, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 50.08804, lon: 14.42076, locations facility: Kardiologicka ambulance, status: NOT_YET_RECRUITING, city: Brandýs nad Labem-Stará Boleslav, state: Praha-východ, zip: 250 01, country: Czechia, contacts name: Jiri Krupicka, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 50.18709, lon: 14.66326, locations facility: Kardioma, status: NOT_YET_RECRUITING, city: Kolin, state: Středočeský Kraj, zip: 280 02, country: Czechia, contacts name: Vit Maratka, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 50.02806, lon: 15.1998, locations facility: Nova kardiologie - Kardiologicka ambulance, status: NOT_YET_RECRUITING, city: Ricany, state: Středočeský Kraj, zip: 251 01, country: Czechia, contacts name: Jan Kohoutek, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 49.99168, lon: 14.65427, locations facility: Clinical Trials Service s.r.o., status: NOT_YET_RECRUITING, city: Uherské Hradiště, state: Zlínský Kraj, zip: 686 01, country: Czechia, contacts name: Vladimir Cech, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 49.06975, lon: 17.45969, locations facility: PreventaMed, status: NOT_YET_RECRUITING, city: Olomouc, zip: 779 00, country: Czechia, contacts name: Jiri Pumprla, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 49.59552, lon: 17.25175, locations facility: Kardiologicka ambulance MUDr. Ferkl s.r.o., status: NOT_YET_RECRUITING, city: Trutnov, zip: 541 01, country: Czechia, contacts name: Richard Ferkl, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 50.56101, lon: 15.9127, locations facility: Cardio Research, s.r.o, status: NOT_YET_RECRUITING, city: Zlín, zip: 760 01, country: Czechia, contacts name: Tomas Fiala, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 49.22645, lon: 17.67065, locations facility: Rigshospitalet, status: NOT_YET_RECRUITING, city: Copenhagen, state: Hovedstaden, zip: 2100, country: Denmark, contacts name: Christian Hassager, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 55.67594, lon: 12.56553, locations facility: Herlev and Gentofte Hospital, status: NOT_YET_RECRUITING, city: Hellerup, state: Hovedstaden, zip: 2900, country: Denmark, contacts name: Gunnar Gislason, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 55.73204, lon: 12.57093, locations facility: Sanos Clinic, status: NOT_YET_RECRUITING, city: Herlev, state: Hovedstaden, zip: 2730, country: Denmark, contacts name: Bernt Husoy, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 55.72366, lon: 12.43998, locations facility: Aarhus Universitetshospital, Skejby, status: NOT_YET_RECRUITING, city: Aarhus, state: Midtjylland, zip: 8200, country: Denmark, contacts name: Henrik Wiggers, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 56.15674, lon: 10.21076, locations facility: Sanos Clinic - Nordjylland, status: NOT_YET_RECRUITING, city: Gandrup, state: Nordjylland, zip: 9362, country: Denmark, contacts name: Cecilie Rovsing, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 56.74249, lon: 9.82298, locations facility: Holbæk Sygehus, status: NOT_YET_RECRUITING, city: Holbaek, state: Sjælland, zip: 4300, country: Denmark, contacts name: Morten Lindhardt, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 55.71354, lon: 11.7169, locations facility: Sygehus Sønderjylland i Aabenraa, status: NOT_YET_RECRUITING, city: Aabenraa, state: Syddanmark, zip: 6200, country: Denmark, contacts name: Frank-Peter Elpert, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 55.04434, lon: 9.41741, locations facility: Sydvestjysk Sygehus Esbjerg, status: NOT_YET_RECRUITING, city: Esbjerg, state: Syddanmark, zip: 6700, country: Denmark, contacts name: Kristian Korsgaard Thomsen, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 55.47028, lon: 8.45187, locations facility: Sanos Clinic - Syddanmark, status: NOT_YET_RECRUITING, city: Vejle, state: Syddanmark, zip: 7100, country: Denmark, contacts name: Peter Alexandersen, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 55.70927, lon: 9.5357, locations facility: CHU de Nice, status: NOT_YET_RECRUITING, city: Nice, state: Alpes-Maritimes, zip: 06000, country: France, contacts name: Emile Ferrari, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 43.70313, lon: 7.26608, locations facility: CHU Strasbourg-Hautepierre, status: NOT_YET_RECRUITING, city: Strasbourg, state: Alsace, zip: 67098, country: France, contacts name: Alain Pradignac, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 48.58392, lon: 7.74553, locations facility: CHU Bordeaux Haut-Leveque, status: NOT_YET_RECRUITING, city: Pessac, state: Aquitaine, zip: 33600, country: France, contacts name: Sami FAWAZ, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 44.81011, lon: -0.64129, locations facility: Hôpital Saint Joseph, status: NOT_YET_RECRUITING, city: Marseille, state: Bouches-du-Rhône, zip: 13285, country: France, contacts name: Patrick KHANOYAN, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 43.29551, lon: 5.38958, locations facility: Centre Hospitalier Universitaire Dijon Bourgogne - Hôpital François Mitterrand, status: NOT_YET_RECRUITING, city: Dijon, state: Bourgogne, zip: 21079, country: France, contacts name: FREDERIC CHAGUE, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 47.31667, lon: 5.01667, locations facility: Centre Hospitalier Universitaire de Rennes - Hôpital Pontchaillou, status: NOT_YET_RECRUITING, city: Rennes, state: Bretagne, zip: 35033, country: France, contacts name: francois paillard, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 48.11198, lon: -1.67429, locations facility: CHRU Troussau, status: NOT_YET_RECRUITING, city: Chambray Les Tours, state: Centre, zip: 37170, country: France, contacts name: Fabrice Ivanes, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 47.33537, lon: 0.70286, locations facility: CHU Besançon, status: NOT_YET_RECRUITING, city: Besançon, state: Doubs, zip: 25000, country: France, contacts name: francois schiele, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 47.24878, lon: 6.01815, locations facility: Centre Hospitalier Louis Pasteur, status: NOT_YET_RECRUITING, city: Le Coudray, state: Eure-et-Loir, zip: 28630, country: France, contacts name: Gregoire Range, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 48.42115, lon: 1.50057, locations facility: Centre Hospitalier Universitaire de Nîmes - Hôpital Universitaire Carémeau, status: NOT_YET_RECRUITING, city: Nîmes, state: Gard, zip: 30029, country: France, contacts name: Guillaume Cayla, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 43.83333, lon: 4.35, locations facility: CHU Rangueil, status: NOT_YET_RECRUITING, city: Toulouse, state: Haute-Garonne, zip: 31059, country: France, contacts name: Meyer Elbaz, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 43.60426, lon: 1.44367, locations facility: CHU Charles Nicolle, status: NOT_YET_RECRUITING, city: Rouen, state: Haute-Normandie, zip: 76031, country: France, contacts name: Eric Durand, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 49.44313, lon: 1.09932, locations facility: CHU Montpellier Lapeyronie Hospital, status: NOT_YET_RECRUITING, city: Montpellier, state: Hérault, zip: 34295, country: France, contacts name: ariane Sultan, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 43.61092, lon: 3.87723, locations facility: Hôpital Nord Guillaume-et-René-Laennec / CHU de Nantes, status: NOT_YET_RECRUITING, city: Nantes Cedex 1, state: Loire-Atlantique, zip: 44093, country: France, contacts name: Bertrand CARIOU, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 47.21725, lon: -1.55336, locations facility: Hopital Claude Huriez - CHU de Lille, status: NOT_YET_RECRUITING, city: Lille, state: Nord, zip: 59037, country: France, contacts name: cecile yelnik, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 50.63297, lon: 3.05858, locations facility: Centre Hospitalier Compiègne-Noyon, status: NOT_YET_RECRUITING, city: Compiègne, state: Oise, zip: 60200, country: France, contacts name: Jerome Clerc, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 49.41794, lon: 2.82606, locations facility: Pitie Salpetriere University Hospital, status: NOT_YET_RECRUITING, city: Paris, state: Orne, zip: 75013, country: France, contacts name: Antonio Gallo, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 48.85341, lon: 2.3488, locations facility: Centre Hospitalier de Pau, status: NOT_YET_RECRUITING, city: Pau, state: Pyrénées-Atlantiques, zip: 64000, country: France, contacts name: NICOLAS DELARCHE, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 43.3, lon: -0.36667, locations facility: Centre Hospitalier Saint Joseph - Saint Luc, status: NOT_YET_RECRUITING, city: Lyon, state: Rhône-Alpes, zip: 69007, country: France, contacts name: Lucien MARCHAND, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 45.74848, lon: 4.84669, locations facility: Hospices Civils de Lyon - Hopital Louis Pradel, status: NOT_YET_RECRUITING, city: Bron, state: Rhône, zip: 69677, country: France, contacts name: Hospices Civils de Lyon - Hopital Louis Pradel, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 45.73333, lon: 4.91667, locations facility: Hôpital Bichat - Claude-Bernard, status: NOT_YET_RECRUITING, city: Paris, zip: 75018, country: France, contacts name: Gabriel Steg, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 48.85341, lon: 2.3488, locations facility: Polyclinique Vauban, status: NOT_YET_RECRUITING, city: Valenciennes, zip: 59300, country: France, contacts name: Sebastien Caudmont, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 50.35, lon: 3.53333, locations facility: Hôpital Avicenne, status: NOT_YET_RECRUITING, city: Bobigny, state: Île-de-France, zip: 93000, country: France, contacts name: Emmanuel Cosson, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 48.9, lon: 2.45, locations facility: Hôpital Européen Georges Pompidou, status: NOT_YET_RECRUITING, city: Paris, state: Île-de-France, zip: 75015, country: France, contacts name: Sebastien CZERNICHOW, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 48.85341, lon: 2.3488, locations facility: Hôpital Saint Antoine, status: NOT_YET_RECRUITING, city: Paris, state: Île-de-France, zip: 75571, country: France, contacts name: FRANCK BOCCARA, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 48.85341, lon: 2.3488, locations facility: ze:ro ARZTPRAXEN, status: RECRUITING, city: Mannheim, state: Baden-Württemberg, zip: 68165, country: Germany, contacts name: Peter Salbach, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 49.4891, lon: 8.46694, locations facility: Universitätsmedizin Mannheim, status: RECRUITING, city: Mannheim, state: Baden-Württemberg, zip: 68167, country: Germany, contacts name: Ksenija Stach-Jablonski, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 49.4891, lon: 8.46694, locations facility: Studienzentrum Herzklinik Ulm MVZ, status: NOT_YET_RECRUITING, city: Ulm, state: Baden-Württemberg, zip: 89077, country: Germany, contacts name: Norbert Jahnke, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 48.39841, lon: 9.99155, locations facility: Deutsches Herzzentrum München, status: RECRUITING, city: Munich, state: Bayern, zip: 80636, country: Germany, contacts name: Wolfgang Koenig, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 48.13743, lon: 11.57549, locations facility: Universitätsklinikum Regensburg, status: NOT_YET_RECRUITING, city: Regensburg, state: Bayern, zip: 93053, country: Germany, contacts name: Andrea Baessler, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 49.01513, lon: 12.10161, locations facility: Kardiologische Gemeinschaftspraxis am Park Sanssouci, status: NOT_YET_RECRUITING, city: Potsdam, state: Brandenburg, zip: 14471, country: Germany, contacts name: Regina Gaub, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 52.39886, lon: 13.06566, locations facility: Kardiologische Praxis Dr. med. univ. Wolfgang Jungmair, status: NOT_YET_RECRUITING, city: Bad Homburg, state: Hessen, zip: 61348, country: Germany, contacts name: Wolfgang Alfred Jungmair, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 50.22683, lon: 8.61816, locations facility: Cardioangiologisches Centrum Bethanien, status: NOT_YET_RECRUITING, city: Frankfurt, state: Hessen, zip: 60389, country: Germany, contacts name: Holger Eggebrecht, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 50.11552, lon: 8.68417, locations facility: Diabetes Zentrum Dr. Tews, status: NOT_YET_RECRUITING, city: Gelnhausen, state: Hessen, zip: 63571, country: Germany, contacts name: Dietrich Tews, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 50.20164, lon: 9.18742, locations facility: GPR Gesundheits- und Pflegezentrum Rüsselsheim, status: NOT_YET_RECRUITING, city: Rüsselsheim, state: Hessen, zip: 65428, country: Germany, contacts name: Ehab Shahock, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 49.98955, lon: 8.42251, locations facility: Praxis Oedeme, status: NOT_YET_RECRUITING, city: Lüneburg, state: Niedersachsen, zip: 21339, country: Germany, contacts name: Hans-Eckart Sarnighausen, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 53.2509, lon: 10.41409, locations facility: Universitätsklinikum Aachen, status: RECRUITING, city: Aachen, state: Nordrhein-Westfalen, zip: 52074, country: Germany, contacts name: Julia Brandts, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 50.77664, lon: 6.08342, locations facility: Klinikum Bielefeld Mitte, status: NOT_YET_RECRUITING, city: Bielefeld, state: Nordrhein-Westfalen, zip: 33604, country: Germany, contacts name: Christoph Stellbrink, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 52.03333, lon: 8.53333, locations facility: Medizentrum Essen Borbeck, status: NOT_YET_RECRUITING, city: Essen, state: Nordrhein-Westfalen, zip: 45355, country: Germany, contacts name: Axel Schaefer, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 51.45657, lon: 7.01228, locations facility: University Hospital of Cologne, status: NOT_YET_RECRUITING, city: Köln, state: Nordrhein-Westfalen, zip: 50937, country: Germany, contacts name: Ioanna Gouni-Berthold, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 50.93333, lon: 6.95, locations facility: Institut für Diabetesforschung GmbH Münster, status: NOT_YET_RECRUITING, city: Münster, state: Nordrhein-Westfalen, zip: 48145, country: Germany, contacts name: Ludger Rose, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 51.96236, lon: 7.62571, locations facility: Universitaet zu Koeln - Sana-Klinikum Remscheid GmbH - Klinik fuer Kardiologie, Pneumologie und Internisti -T, status: NOT_YET_RECRUITING, city: Remscheid, state: Nordrhein-Westfalen, zip: 42859, country: Germany, contacts name: Burkhard Sievers, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 51.17983, lon: 7.1925, locations facility: Zentrum für klinische Studien, status: RECRUITING, city: Saint Ingbert, state: Saarland, zip: 66386, country: Germany, contacts name: Alexander Segner, role: PRINCIPAL_INVESTIGATOR, locations facility: Otto-von-Guericke-Universität Magdeburg, status: NOT_YET_RECRUITING, city: Magdeburg, state: Sachsen-Anhalt, zip: 39120, country: Germany, contacts name: Rüdiger Braun-Dullaeus, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 52.12773, lon: 11.62916, locations facility: Hausärztlich-Kardiologisches MVZ am Felsenkeller GmbH/Zentrum für klinische Studien, status: NOT_YET_RECRUITING, city: Dresden, state: Sachsen, zip: 01277, country: Germany, contacts name: Maria Kaiser, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 51.05089, lon: 13.73832, locations facility: Herzzentrum Dresden GmbH Universitätsklinik, status: NOT_YET_RECRUITING, city: Dresden, state: Sachsen, zip: 01307, country: Germany, contacts name: Felix Matthias Heidrich, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 51.05089, lon: 13.73832, locations facility: Universitaetsklinikum Carl Gustav Carus Dresden, status: NOT_YET_RECRUITING, city: Dresden, state: Sachsen, zip: 01307, country: Germany, contacts name: Nikolaos Perakakis, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 51.05089, lon: 13.73832, locations facility: Universitätsklinikum Leipzig, status: NOT_YET_RECRUITING, city: Leipzig, state: Sachsen, zip: 04103, country: Germany, contacts name: Irina Mueller-Kozarez, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 51.33962, lon: 12.37129, locations facility: Herzzentrum Leipzig GmbH, status: NOT_YET_RECRUITING, city: Leipzig, state: Sachsen, zip: 04289, country: Germany, contacts name: Holger Thiele, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 51.33962, lon: 12.37129, locations facility: Universitätsklinikum Jena, status: NOT_YET_RECRUITING, city: Jena, state: Thüringen, zip: 07747, country: Germany, contacts name: Oliver Weingärtner, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 50.92878, lon: 11.5899, locations facility: Klinikum am Plattenwald, status: NOT_YET_RECRUITING, city: Bad Friedrichshall, zip: 74177, country: Germany, contacts name: Thomas Dengler, role: PRINCIPAL_INVESTIGATOR, locations facility: Kardiologische Praxen im Spreebogen, status: NOT_YET_RECRUITING, city: Berlin, zip: 10559, country: Germany, contacts name: Florian Krackhardt, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 52.52437, lon: 13.41053, locations facility: Praxis Rankestrasse, status: NOT_YET_RECRUITING, city: Berlin, zip: 10789, country: Germany, contacts name: Werner Albert Rieker, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 52.52437, lon: 13.41053, locations facility: DRK Kliniken Berlin - Köpenick, status: NOT_YET_RECRUITING, city: Berlin, zip: 12559, country: Germany, contacts name: Martin Lange, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 52.52437, lon: 13.41053, locations facility: Charité Campus Virchow-Klinikum, status: NOT_YET_RECRUITING, city: Berlin, zip: 13353, country: Germany, contacts name: Ursula Kassner, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 52.52437, lon: 13.41053, locations facility: Cardiologicum Hamburg, status: NOT_YET_RECRUITING, city: Hamburg, zip: 22041, country: Germany, contacts name: Martin W. Bergmann, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 53.57532, lon: 10.01534, locations facility: Iatriko Paleou Falirou Medical Center, status: NOT_YET_RECRUITING, city: Paleo Faliro, state: Attikí (Region), zip: 17562, country: Greece, contacts name: John Doupis, role: PRINCIPAL_INVESTIGATOR, locations facility: Athens Naval Hospital, status: NOT_YET_RECRUITING, city: Athens, state: Attikí, zip: 11521, country: Greece, contacts name: Anastasios Milkas, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 37.97945, lon: 23.71622, locations facility: General Hospital of Athens Laiko, status: NOT_YET_RECRUITING, city: Athens, state: Attikí, zip: 11527, country: Greece, contacts name: Evangelos Liberopoulos, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 37.97945, lon: 23.71622, locations facility: Athens Medical Center, status: NOT_YET_RECRUITING, city: Athens, state: Attikí, zip: 151 25, country: Greece, contacts name: Georgia Argyrakopoulou, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 37.97945, lon: 23.71622, locations facility: Attikon General University Hospital, status: NOT_YET_RECRUITING, city: Chaidari, state: Attikí, zip: 12462, country: Greece, contacts name: Vaia Lambadiari, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 38.01135, lon: 23.66597, locations facility: University Hospital of Ioannina, status: NOT_YET_RECRUITING, city: Ioannina, state: Ioánnina, zip: 45500, country: Greece, contacts name: Vasileios Tsimichodimos, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 39.66486, lon: 20.85189, locations facility: University General Hospital of Heraklion, status: NOT_YET_RECRUITING, city: Heraklion, state: Irakleío, zip: 71110, country: Greece, contacts name: Theodosios Filippatos, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 35.32787, lon: 25.14341, locations facility: AHEPA University General Hospital of Thessaloniki, status: NOT_YET_RECRUITING, city: Thessaloniki, state: Kentrikí Makedonía, zip: 546 36, country: Greece, contacts name: Konstantinos Tziomalos, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 40.64361, lon: 22.93086, locations facility: Papageorgiou General Hospital of Thessaloniki, status: NOT_YET_RECRUITING, city: Thessaloniki, state: Thessaloníki, zip: 564 29, country: Greece, contacts name: Glykeria Tzatzagou, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 40.64361, lon: 22.93086, locations facility: Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ, status: NOT_YET_RECRUITING, city: Szeged, state: Csongrád, zip: 6725, country: Hungary, contacts name: Robert Takacs, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 46.253, lon: 20.14824, locations facility: Vita Verum Medical Egeszsegugyi Szolgaltato, status: NOT_YET_RECRUITING, city: Szekesfehervar, state: Fejér, zip: 8000, country: Hungary, contacts name: Amalia Benedek, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 47.18995, lon: 18.41034, locations facility: Medifarma 98 Kft, status: NOT_YET_RECRUITING, city: Nyiregyhaza, state: Nyíregyháza, zip: 4400, country: Hungary, contacts name: Zsolt Zilahi, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 47.95539, lon: 21.71671, locations facility: DRC Gyógyszervizsgáló Központ, status: NOT_YET_RECRUITING, city: Balatongyorok, state: Veszprém, zip: 8313, country: Hungary, contacts name: Margit Dudás, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 46.75833, lon: 17.35462, locations facility: Belvárosi Egészségház, status: NOT_YET_RECRUITING, city: Zalaegerszeg, state: Zala, zip: 8900, country: Hungary, contacts name: Geza Lupkovics, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 46.84, lon: 16.84389, locations facility: Szent Margit Rendelőintézet Nonprofit Kft, status: NOT_YET_RECRUITING, city: Budapest, zip: 1032, country: Hungary, contacts name: Timea Tänczer, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 47.49801, lon: 19.03991, locations facility: Magyar Honvedseg Egeszsegugyi Kozpont, status: NOT_YET_RECRUITING, city: Budapest, zip: 1062, country: Hungary, contacts name: Erika Maria Hubina, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 47.49801, lon: 19.03991, locations facility: Semmelweis University, status: NOT_YET_RECRUITING, city: Budapest, zip: 1122, country: Hungary, contacts name: Béla Merkely, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 47.49801, lon: 19.03991, locations facility: Privát Doktor Egészségügyi Zrt, status: NOT_YET_RECRUITING, city: Budapest, zip: 1132, country: Hungary, contacts name: Andras R Vertes, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 47.49801, lon: 19.03991, locations facility: Debreceni Egyetem Klinikai Kozpont, status: NOT_YET_RECRUITING, city: Debrecen, zip: 4032, country: Hungary, contacts name: Denes Pall, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 47.53333, lon: 21.63333, locations facility: All India Institute of Medical Sciences, status: NOT_YET_RECRUITING, city: Raipur, state: Chhattisgarh, zip: 492099, country: India, contacts name: Satyajit Singh, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 21.23333, lon: 81.63333, locations facility: G.B. Pant Institute of Postgraduate Medical Education & Research, status: NOT_YET_RECRUITING, city: New Delhi, state: Delhi, zip: 110002, country: India, contacts name: Vimal Mehta, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 28.63576, lon: 77.22445, locations facility: KLES Dr. Prabhakar Kore Hospital & M.R.C, status: NOT_YET_RECRUITING, city: Belagavi, state: Karnataka, zip: 590010, country: India, contacts name: Prasad M R, role: PRINCIPAL_INVESTIGATOR, locations facility: Lisie Hospital, status: NOT_YET_RECRUITING, city: Kochi, state: Kerala, zip: 682018, country: India, contacts name: Jabir Abdullakutty, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 9.93988, lon: 76.26022, locations facility: Government Medical College - Kozhikode, status: NOT_YET_RECRUITING, city: Kozhikode, state: Kerala, zip: 673008, country: India, contacts name: Neeraj Manikath, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 11.24802, lon: 75.7804, locations facility: Vijan Hospital & Research Centre, status: NOT_YET_RECRUITING, city: Nashik, state: Maharashtra, zip: 422005, country: India, contacts name: Vikrant Vijan, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 19.99727, lon: 73.79096, locations facility: Sardar Patel Medical College, status: NOT_YET_RECRUITING, city: Bikaner, state: Rajasthan, zip: 334001, country: India, contacts name: Devendra Agarwal, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 28.01762, lon: 73.31495, locations facility: K care Hospital, status: NOT_YET_RECRUITING, city: Kanpur, state: Uttar Pradesh, zip: 208001, country: India, contacts name: Amit Kumar Gupta, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 26.46523, lon: 80.34975, locations facility: King George's Medical University, status: NOT_YET_RECRUITING, city: Lucknow, state: Uttar Pradesh, zip: 226003, country: India, contacts name: S. K. Dwivedi, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 26.83928, lon: 80.92313, locations facility: Shri Mahant Indiresh Hospital, status: NOT_YET_RECRUITING, city: Dehradun, state: Uttarakhand, zip: 248001, country: India, contacts name: Tanuj Bhatia, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 30.32295, lon: 78.03168, locations facility: Soroka Medical Center, status: NOT_YET_RECRUITING, city: Be'er Sheva, state: HaDarom, zip: 8410101, country: Israel, contacts name: Itzhak Gabizon, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 31.25181, lon: 34.7913, locations facility: Edith Wolfson Medical Center, status: NOT_YET_RECRUITING, city: Holon, state: HaMerkaz, zip: 5810001, country: Israel, contacts name: orit twito, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 32.01034, lon: 34.77918, locations facility: Meir Medical Center, status: NOT_YET_RECRUITING, city: Kfar Saba, state: HaMerkaz, zip: 4428164, country: Israel, contacts name: Victor Vishlitzky, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 32.175, lon: 34.90694, locations facility: Rabin Medical Center, status: NOT_YET_RECRUITING, city: Petah Tikva, state: HaMerkaz, zip: 4941492, country: Israel, contacts name: Avishay Elis, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 32.08707, lon: 34.88747, locations facility: Rabin Medical Center, status: NOT_YET_RECRUITING, city: Petah-Tikva, state: HaMerkaz, zip: 4941492, country: Israel, contacts name: Alejandro Solodky, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 32.08707, lon: 34.88747, locations facility: Sheba Medical Center, status: NOT_YET_RECRUITING, city: Ramat Gan, state: HaMerkaz, zip: 5262100, country: Israel, contacts name: Michael Shechter, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 32.08227, lon: 34.81065, locations facility: Sheba Medical Center, status: NOT_YET_RECRUITING, city: Ramat Gan, state: HaMerkaz, zip: 5265601, country: Israel, contacts name: Hofit Cohen, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 32.08227, lon: 34.81065, locations facility: Kaplan Medical Center, status: NOT_YET_RECRUITING, city: Rehovot, state: HaMerkaz, zip: 7610001, country: Israel, contacts name: Viviana Ostrovsky, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 31.89421, lon: 34.81199, locations facility: Rambam Health Care Campus, status: RECRUITING, city: Haifa, state: HaTsafon, zip: 3109601, country: Israel, contacts name: oren caspi, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 32.81841, lon: 34.9885, locations facility: Galilee Medical Center, status: NOT_YET_RECRUITING, city: Nahariya, state: HaTsafon, zip: 2210001, country: Israel, contacts name: Shaul Atar, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 33.00892, lon: 35.09814, locations facility: Sourasky Medical Center, status: NOT_YET_RECRUITING, city: Tel Aviv, state: Tell Abīb, zip: 6423906, country: Israel, contacts name: Elena Izkhakov, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 32.08088, lon: 34.78057, locations facility: Sourasky Medical Center, status: NOT_YET_RECRUITING, city: Tel Aviv, state: Tell Abīb, zip: 6423906, country: Israel, contacts name: Yaron Arbel, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 32.08088, lon: 34.78057, locations facility: Shaare Zedek Medical Center, status: NOT_YET_RECRUITING, city: Jerusalem, state: Yerushalayim, zip: 9013102, country: Israel, contacts name: Dov Gavish, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 31.76904, lon: 35.21633, locations facility: Hadassah Medical Center, status: RECRUITING, city: Jerusalem, state: Yerushalayim, zip: 9112001, country: Israel, contacts name: Ronen Durst, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 31.76904, lon: 35.21633, locations facility: Hadassah Medical Center, status: RECRUITING, city: Jerusalem, state: Yerushalayim, zip: 9112001, country: Israel, contacts name: Daniel Schurr, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 31.76904, lon: 35.21633, locations facility: Rambam Health Care Campus, status: NOT_YET_RECRUITING, city: Haifa, state: Ḥeifā, zip: 3109601, country: Israel, contacts name: Tony Hayek, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 32.81841, lon: 34.9885, locations facility: Carmel Hospital, status: NOT_YET_RECRUITING, city: Haifa, state: Ḥeifā, zip: 3436212, country: Israel, contacts name: BARAK ZAFRIR, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 32.81841, lon: 34.9885, locations facility: Azienda Ospedaliero Universitaria S.Anna, status: NOT_YET_RECRUITING, city: Ferrara, state: Emilia-Romagna, zip: 44100, country: Italy, contacts name: Alessandro Fucili, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 44.83804, lon: 11.62057, locations facility: Policlinico Umberto I, status: NOT_YET_RECRUITING, city: Rome, state: Lazio, zip: 00161, country: Italy, contacts name: Marcello Arca, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 41.89193, lon: 12.51133, locations facility: Ospedale San Martino, status: NOT_YET_RECRUITING, city: Genova, state: Liguria, zip: 16132, country: Italy, contacts name: LIVIA PISCIOTTA, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 44.40478, lon: 8.94438, locations facility: Ospedale Bassini, status: NOT_YET_RECRUITING, city: Cinisello Balsamo, state: Milano, zip: 20092, country: Italy, contacts name: Paolo Fabbrini, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 45.55823, lon: 9.21495, locations facility: Centro Cardiologico Monzino, status: NOT_YET_RECRUITING, city: Milan, state: Milano, zip: 20138, country: Italy, contacts name: José Pablo Werba, role: SUB_INVESTIGATOR, geoPoint lat: 45.46427, lon: 9.18951, locations facility: ASST Grande Ospedale Metropolitano Niguarda, status: NOT_YET_RECRUITING, city: Milan, state: Milano, zip: 20162, country: Italy, contacts name: Alessandro Maloberti, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 45.46427, lon: 9.18951, locations facility: Ospedale di Baggiovara, status: NOT_YET_RECRUITING, city: Baggiovara, state: Modena, zip: 41126, country: Italy, contacts name: Fabio Nascimbeni, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 44.60416, lon: 10.86256, locations facility: Azienda Ospedaliera Universitaria Careggi, status: NOT_YET_RECRUITING, city: Firenze, state: Toscana, zip: 50134, country: Italy, contacts name: rossella marcucci, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 43.77925, lon: 11.24626, locations facility: Azienda Ospedaliera Universitaria Pisana, status: NOT_YET_RECRUITING, city: Pisa, state: Toscana, zip: 56124, country: Italy, contacts name: Ferruccio Santini, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 43.70853, lon: 10.4036, locations facility: Fondazione G. Monasterio, status: NOT_YET_RECRUITING, city: Pisa, state: Toscana, zip: 56124, country: Italy, contacts name: Francesco Sbrana, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 43.70853, lon: 10.4036, locations facility: Ospedale Cazzavillan di Arzignano, status: NOT_YET_RECRUITING, city: Arzignano, state: Veneto, zip: 36071, country: Italy, contacts name: Claudio Bilato, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 45.52027, lon: 11.33446, locations facility: Azienda Ospedaliera di Padova, status: NOT_YET_RECRUITING, city: Padova, state: Veneto, zip: 35128, country: Italy, contacts name: Alberto Zambon, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 45.40797, lon: 11.88586, locations facility: IRCCS - AOU di Bologna, status: NOT_YET_RECRUITING, city: Bologna, zip: 40138, country: Italy, contacts name: Claudio Borghi, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 44.49381, lon: 11.33875, locations facility: Ospedale San Raffaele, status: NOT_YET_RECRUITING, city: Milano, zip: 20132, country: Italy, contacts name: Emanuela Setola, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 45.46427, lon: 9.18951, locations facility: Hospital Santa Maria della Misericordia in Perugia, status: NOT_YET_RECRUITING, city: Perugia, zip: 06156, country: Italy, contacts name: Matteo Pirro, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 43.1122, lon: 12.38878, locations facility: Kasugai Municipal Hospital, status: RECRUITING, city: Kasugai, state: Aichi, zip: 486-8510, country: Japan, contacts name: Mitsutoshi Oguri, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 35.24762, lon: 136.97229, locations facility: Nagoya City University Hospital, status: NOT_YET_RECRUITING, city: Nagoya, state: Aichi, zip: 467-8602, country: Japan, contacts name: Tomohiro Tanaka, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 35.18147, lon: 136.90641, locations facility: Asahi Hospital - Asahi, status: RECRUITING, city: Asahi, state: Chiba, zip: 289-2511, country: Japan, contacts name: Shunichi Kushida, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 35.71667, lon: 140.65, locations facility: Saiseikai Futsukaichi Hospital, status: RECRUITING, city: Chikushino, state: Fukuoka, zip: 818-8516, country: Japan, contacts name: Toshiaki Kadokami, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 33.49631, lon: 130.5156, locations facility: Kokura Memorial Hospital, status: NOT_YET_RECRUITING, city: Kitakyushu, state: Fukuoka, zip: 802-8555, country: Japan, contacts name: Kenji Ando, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 33.85181, lon: 130.85034, locations facility: Chugoku Rosai Hospital, status: NOT_YET_RECRUITING, city: Kure, state: Hiroshima, zip: 737-0193, country: Japan, contacts name: Keiji Matsuda, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 34.23222, lon: 132.56658, locations facility: Asahikawa City Hospital, status: RECRUITING, city: Asahikawa, state: Hokkaido, zip: 070-8610, country: Japan, contacts name: Yoshihiro Miyamoto, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 43.77063, lon: 142.36489, locations facility: Hospital Hakodate Hokkaido, status: NOT_YET_RECRUITING, city: Hakodate, state: Hokkaido, zip: 041-8680, country: Japan, contacts name: Yusuke Tokuda, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 41.77583, lon: 140.73667, locations facility: Tokeidai Memorial Hospital, status: NOT_YET_RECRUITING, city: Sapporo, state: Hokkaido, zip: 060-0031, country: Japan, contacts name: Michinao Tan, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 43.06667, lon: 141.35, locations facility: Sapporo Medical University Hospital, status: NOT_YET_RECRUITING, city: Sapporo, state: Hokkaido, zip: 060-8543, country: Japan, contacts name: Masato Furuhashi, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 43.06667, lon: 141.35, locations facility: Japan Community Healthcare Organization Hokkaido Hospital, status: RECRUITING, city: Sapporo, state: Hokkaido, zip: 062-8618, country: Japan, contacts name: Masashige Takahashi, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 43.06667, lon: 141.35, locations facility: Hyogo Prefectural Harima-Himeji General Medical Center, status: RECRUITING, city: Himeji, state: Hyogo, zip: 670-8560, country: Japan, contacts name: Tomofumi Takaya, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 34.81667, lon: 134.7, locations facility: Kobe City Medical Center General Hospital, status: NOT_YET_RECRUITING, city: Kobe, state: Hyogo, zip: 650-0047, country: Japan, contacts name: Yutaka Furukawa, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 34.6913, lon: 135.183, locations facility: Higashi Takarazuka Satoh Hospital, status: RECRUITING, city: Takarazuka, state: Hyogo, zip: 665-0873, country: Japan, contacts name: Katsuyuki Hasegawa, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 34.79936, lon: 135.35697, locations facility: Takasago Seibu Hospital, status: RECRUITING, city: Takasago, state: Hyogo, zip: 676-0812, country: Japan, contacts name: Katsunari Matsuoka, role: PRINCIPAL_INVESTIGATOR, locations facility: Tsuchiura Kyodo General Hospital, status: RECRUITING, city: Tsuchiura, state: Ibaraki, zip: 300-0028, country: Japan, contacts name: TSUNEKAZU KAKUTA, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 36.09047, lon: 140.21047, locations facility: Public Matto Ishikawa Central Hospital, status: NOT_YET_RECRUITING, city: Hakusan, state: Ishikawa, zip: 924-0865, country: Japan, contacts name: HIROYUKI ODA, role: PRINCIPAL_INVESTIGATOR, locations facility: Ishikawa Prefectural Central Hospital, status: NOT_YET_RECRUITING, city: Kanazawa, state: Ishikawa, zip: 920-8530, country: Japan, contacts name: Kenji Miwa, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 36.6, lon: 136.61667, locations facility: National Hospital Organization Kanazawa Medical Center, status: RECRUITING, city: Kanazawa, state: Ishikawa, zip: 920-8650, country: Japan, contacts name: Takahiro Saeki, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 36.6, lon: 136.61667, locations facility: Komatsu Municipal Hospital, status: NOT_YET_RECRUITING, city: Komatsu, state: Ishikawa, zip: 923-8560, country: Japan, contacts name: Toshinori Higashikata, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 36.40263, lon: 136.45088, locations facility: Kanazawa Medical University Hospital, status: RECRUITING, city: Uchinada, state: Ishikawa, zip: 920-0293, country: Japan, contacts name: Kouji Kajinami, role: PRINCIPAL_INVESTIGATOR, locations facility: Iwate Prefectural Central Hospital, status: RECRUITING, city: Morioka, state: Iwate, zip: 020-0066, country: Japan, contacts name: Akihiro Nakamura, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 39.7, lon: 141.15, locations facility: Kagawa Prefectural Central Hospital, status: NOT_YET_RECRUITING, city: Takamatsu, state: Kagawa, zip: 760-8557, country: Japan, contacts name: Masayuki Doi, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 34.33333, lon: 134.05, locations facility: Tokai University Hospital- Isehara Campus, status: NOT_YET_RECRUITING, city: Isehara, state: Kanagawa, zip: 259-1193, country: Japan, contacts name: Tsutomu Murakami, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 35.39932, lon: 139.31019, locations facility: Takai Internal Medicine Clinic, status: RECRUITING, city: Kamakura-shi, state: Kanagawa, zip: 247-0056, country: Japan, contacts name: Masahiko Takai, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 35.30889, lon: 139.55028, locations facility: Shonan Oiso Hospital, status: RECRUITING, city: Naka-gun, state: Kanagawa, zip: 259-0114, country: Japan, contacts name: Saeko Takahashi, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 36.05, lon: 140.16667, locations facility: Kitasato University Hospital, status: NOT_YET_RECRUITING, city: Sagamihara, state: Kanagawa, zip: 252-0375, country: Japan, contacts name: Junya Ako, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 35.54899, lon: 139.26064, locations facility: Saiseikai Yokohamashi Tobu Hospital, status: NOT_YET_RECRUITING, city: Yokohama, state: Kanagawa, zip: 230-8765, country: Japan, contacts name: Takamasa Ichijo, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 35.43333, lon: 139.65, locations facility: Yokosukakyosai, status: NOT_YET_RECRUITING, city: Yokosuka, state: Kanagawa, zip: 238-8558, country: Japan, contacts name: Keiichi Hishikari, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 35.28361, lon: 139.66722, locations facility: Osaki Citizen Hospital - Furukawahonami, status: NOT_YET_RECRUITING, city: Ōsaki, state: Miyagi, zip: 989-6183, country: Japan, contacts name: Junpei Yamamoto, role: PRINCIPAL_INVESTIGATOR, locations facility: Miyakonojo Medical Association Hospital - Tarobocho, status: RECRUITING, city: Miyakonojo, state: Miyazaki, zip: 885-0002, country: Japan, contacts name: Hironao Iwakiri, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 31.73333, lon: 131.06667, locations facility: Aizawa Hospital, status: NOT_YET_RECRUITING, city: Matsumoto, state: Nagano, zip: 390-8510, country: Japan, contacts name: Koh Yamashita, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 36.23333, lon: 137.96667, locations facility: National Hospital Organization Shinshu Ueda Medical Center, status: NOT_YET_RECRUITING, city: Ueda, state: Nagano, zip: 386-8610, country: Japan, contacts name: Yasufumi Takahashi, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 36.40265, lon: 138.28161, locations facility: Tachikawa Medical Center, status: NOT_YET_RECRUITING, city: Nagaoka, state: Niigata, zip: 940-8621, country: Japan, contacts name: Koichi Fuse, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 37.45, lon: 138.85, locations facility: Kurashiki Central Hospital, status: NOT_YET_RECRUITING, city: Kurashiki, state: Okayama, zip: 710-8602, country: Japan, contacts name: Kazushige Kadota, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 34.58333, lon: 133.76667, locations facility: Rinku General Medical Center, status: RECRUITING, city: Izumisano, state: Osaka, zip: 598-8577, country: Japan, contacts name: Daisaku Masuda, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 34.41663, lon: 135.31667, locations facility: Medical Corporation Heishinkai OCROM Clinic, status: RECRUITING, city: Suita-shi, state: Osaka, zip: 565-0853, country: Japan, contacts name: Satoshi Inoue, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 34.76143, lon: 135.51567, locations facility: National Cerebral and Cardiovascular Center, status: NOT_YET_RECRUITING, city: Suita, state: Osaka, zip: 564-8565, country: Japan, contacts name: Yu Kataoka, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 34.76143, lon: 135.51567, locations facility: Osaka Medical and Pharmaceutical University Hospital, status: NOT_YET_RECRUITING, city: Takatsuki, state: Osaka, zip: 569-8686, country: Japan, contacts name: Masaaki Hoshiga, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 34.84833, lon: 135.61678, locations facility: Shizuoka Medical Center, status: NOT_YET_RECRUITING, city: Sunto-gun, state: Shizuoka, zip: 411-8611, country: Japan, contacts name: Jun Tanabe, role: PRINCIPAL_INVESTIGATOR, locations facility: International University of Health and Welfare Hospital, status: NOT_YET_RECRUITING, city: Nasushiobara, state: Tochigi, zip: 329-2763, country: Japan, contacts name: Morihiko Takeda, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 36.97817, lon: 140.03054, locations facility: The Institute for Adult Disease, Asahi Life Foundation, status: RECRUITING, city: Chuo-ku, state: Tokyo, zip: 103-0002, country: Japan, contacts name: Yukiko Onishi, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 35.57779, lon: 139.71685, locations facility: Fukuwa Clinic, status: RECRUITING, city: Chuo-ku, state: Tokyo, zip: 104-0031, country: Japan, contacts name: Yasushi Fukushima, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 35.57779, lon: 139.71685, locations facility: National Hospital Organization Tokyo Medical Center, status: NOT_YET_RECRUITING, city: Meguro-ku, state: Tokyo, zip: 152-8902, country: Japan, contacts name: Kojiro Tanimoto, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 42.12755, lon: 143.31736, locations facility: Nogata Clinic, status: RECRUITING, city: Nakano-ku, state: Tokyo, zip: 165-0027, country: Japan, contacts name: Shinji Wakui, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 36.75, lon: 138.36667, locations facility: Medical Corporation Sato Medical clinic, status: NOT_YET_RECRUITING, city: Ootaku, state: Tokyo, zip: 143-0015, country: Japan, contacts name: Nobuyuki Sato, role: PRINCIPAL_INVESTIGATOR, locations facility: Heishinkai Medical Group ToCROM Clinic, status: RECRUITING, city: Shinjuku-ku, state: Tokyo, zip: 160-0008, country: Japan, contacts name: Osamu Matsuoka, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 35.2946, lon: 139.57059, locations facility: Center Hospital of the National Center for Global Health and Medicine, status: NOT_YET_RECRUITING, city: Shinjyuku-ku, state: Tokyo, zip: 162-8655, country: Japan, contacts name: Yukio Hiroi, role: PRINCIPAL_INVESTIGATOR, locations facility: Sekino Hospital, status: RECRUITING, city: Toshimaku, state: Tokyo, zip: 171-0014, country: Japan, contacts name: Hisakuni Sekino, role: PRINCIPAL_INVESTIGATOR, locations facility: Toyama University Hospital, status: NOT_YET_RECRUITING, city: Toyoma, state: Toyama, zip: 930-0194, country: Japan, contacts name: Hiroshi Ueno, role: PRINCIPAL_INVESTIGATOR, locations facility: Tokuyama Central Hospital, status: NOT_YET_RECRUITING, city: Shunan, state: Yamaguchi, zip: 745-8522, country: Japan, contacts name: Takatoshi Wakeyama, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 34.08053, lon: 131.82564, locations facility: University of Yamanashi Hospital, status: NOT_YET_RECRUITING, city: Chuo, state: Yamanashi, zip: 409-3898, country: Japan, contacts name: Takamitsu Nakamura, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 35.57779, lon: 139.71685, locations facility: Fukuoka Wajiro Hospital, status: NOT_YET_RECRUITING, city: Fukuoka, zip: 811-0213, country: Japan, contacts name: Takeshi Serikawa, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 33.6, lon: 130.41667, locations facility: Tenyoukai Chuo Clinic, status: RECRUITING, city: Kagoshima, zip: 892-0822, country: Japan, contacts name: Nobuhiko Atsuchi, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 31.56667, lon: 130.55, locations facility: Jinnouchi Hospital, status: RECRUITING, city: Kumamoto, zip: 862-0976, country: Japan, contacts name: Hideaki Jinnouchi, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 32.80589, lon: 130.69182, locations facility: Rakuwakai Marutamachi Hospital, status: RECRUITING, city: Kyoto, zip: 604-8401, country: Japan, contacts name: Shinichiro Yamaguchi, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 35.02107, lon: 135.75385, locations facility: Rakuwakai Otowa Hospital, status: RECRUITING, city: Kyoto, zip: 607-8062, country: Japan, contacts name: Hirokazu Yokoi, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 35.02107, lon: 135.75385, locations facility: Miyazaki Medical Association Hospital, status: RECRUITING, city: Miyazaki, zip: 880-2102, country: Japan, contacts name: Yoshisato Shibata, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 31.91667, lon: 131.41667, locations facility: Okayama City General Medical Center Okayama City Hospital, status: RECRUITING, city: Okayama, zip: 700-8557, country: Japan, contacts name: Yusuke Kawai, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 34.65, lon: 133.93333, locations facility: National Hospital Organization Okayama Medical Center, status: NOT_YET_RECRUITING, city: Okayama, zip: 701-1192, country: Japan, contacts name: Atsuyuki Watanabe, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 34.65, lon: 133.93333, locations facility: National Hospital Organization - Osaka National Hospital - Institute For Clinical Research, status: NOT_YET_RECRUITING, city: Osaka, zip: 540-0006, country: Japan, contacts name: Yasunori Ueda, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 34.69374, lon: 135.50218, locations facility: Osaka Police Hospital, status: RECRUITING, city: Osaka, zip: 543-0035, country: Japan, contacts name: Yoshiharu Higuchi, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 34.69374, lon: 135.50218, locations facility: Kansai Electric Power Hospital, status: NOT_YET_RECRUITING, city: Osaka, zip: 553-0003, country: Japan, contacts name: Yoshiyuki Initials Hamamoto, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 34.69374, lon: 135.50218, locations facility: Osaka General Medical Center, status: NOT_YET_RECRUITING, city: Osaka, zip: 558-8558, country: Japan, contacts name: Takahisa Yamada, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 34.69374, lon: 135.50218, locations facility: Saga University Hospital, status: NOT_YET_RECRUITING, city: Saga, zip: 849-8501, country: Japan, contacts name: Koichi Node, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 33.23333, lon: 130.3, locations facility: Sanai Hospital - Saitama, status: NOT_YET_RECRUITING, city: Saitama, zip: 338-0837, country: Japan, contacts name: Akitaka Nakata, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 35.90807, lon: 139.65657, locations facility: Gachon University Gil Medical Center, status: RECRUITING, city: Namdong-gu, state: Incheon-gwangyeoksi [Incheon], zip: 21565, country: Korea, Republic of, contacts name: Youngwoo Jang, role: PRINCIPAL_INVESTIGATOR, locations facility: Yonsei University-Wonju Severance Christian Hospital, status: RECRUITING, city: Wonju, state: Kang-won-do, zip: 26426, country: Korea, Republic of, contacts name: Byung-Su Yoo, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 37.35139, lon: 127.94528, locations facility: Chonnam National University Hospital, status: RECRUITING, city: Gwangju-si, state: Kwangju-Kwangyǒkshi, zip: 61469, country: Korea, Republic of, contacts name: Youngkeun Ahn, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 35.15472, lon: 126.91556, locations facility: The Catholic University of Korea, Bucheon St. Mary's Hospital, status: RECRUITING, city: Bucheon-si, state: Kyǒnggi-do, zip: 14647, country: Korea, Republic of, contacts name: SoonJib Yoo, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 37.49889, lon: 126.78306, locations facility: Seoul National University Bundang Hospital, status: NOT_YET_RECRUITING, city: Seongnam, state: Kyǒnggi-do, zip: 13620, country: Korea, Republic of, contacts name: IN-HO CHAE, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 37.43861, lon: 127.13778, locations facility: Seoul National University Bundang Hospital, status: NOT_YET_RECRUITING, city: Seongnam, state: Kyǒnggi-do, zip: 13620, country: Korea, Republic of, contacts name: Sung Hee Choi, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 37.43861, lon: 127.13778, locations facility: Sejong General Hospital, status: NOT_YET_RECRUITING, city: Sosa-gu, state: Kyǒnggi-do, zip: 14754, country: Korea, Republic of, contacts name: Hyun-Jong Lee, role: PRINCIPAL_INVESTIGATOR, locations facility: The Catholic University Of Korea St. Vincent's Hospital, status: NOT_YET_RECRUITING, city: Suwon-si, state: Kyǒnggi-do, zip: 16247, country: Korea, Republic of, contacts name: Seung Hyun Ko, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 37.29111, lon: 127.00889, locations facility: Boramae Medical Center, status: NOT_YET_RECRUITING, city: Dongjak-gu, state: Seoul-teukbyeolsi [Seoul], zip: 07061, country: Korea, Republic of, contacts name: Min Kyong Moon, role: PRINCIPAL_INVESTIGATOR, locations facility: Boramae Medical Center, status: NOT_YET_RECRUITING, city: Dongjak-gu, state: Seoul-teukbyeolsi [Seoul], zip: 07061, country: Korea, Republic of, contacts name: SANG-HYUN KIM, role: PRINCIPAL_INVESTIGATOR, locations facility: Kyung Hee University Hospital, status: NOT_YET_RECRUITING, city: Seoul, state: Seoul-teukbyeolsi [Seoul], zip: 02447, country: Korea, Republic of, contacts name: Weon Kim, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 37.566, lon: 126.9784, locations facility: Korea University Anam Hospital, status: RECRUITING, city: Seoul, state: Seoul-teukbyeolsi [Seoul], zip: 02841, country: Korea, Republic of, contacts name: Soon Jun Hong, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 37.566, lon: 126.9784, locations facility: Seoul National University Hospital, status: NOT_YET_RECRUITING, city: Seoul, state: Seoul-teukbyeolsi [Seoul], zip: 03080, country: Korea, Republic of, contacts name: Hyun-Jae Kang, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 37.566, lon: 126.9784, locations facility: Kangbuk Samsung Hospital, status: RECRUITING, city: Seoul, state: Seoul-teukbyeolsi [Seoul], zip: 03181, country: Korea, Republic of, contacts name: ByungJin Kim, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 37.566, lon: 126.9784, locations facility: Severance Hospital, Yonsei University Health System, status: NOT_YET_RECRUITING, city: Seoul, state: Seoul-teukbyeolsi [Seoul], zip: 03722, country: Korea, Republic of, contacts name: Sang-Hak Lee, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 37.566, lon: 126.9784, locations facility: Asan Medical Center, status: NOT_YET_RECRUITING, city: Seoul, state: Seoul-teukbyeolsi [Seoul], zip: 05505, country: Korea, Republic of, contacts name: KI HOON HAN, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 37.566, lon: 126.9784, locations facility: Asan Medical Center, status: NOT_YET_RECRUITING, city: Seoul, state: Seoul-teukbyeolsi [Seoul], zip: 05505, country: Korea, Republic of, contacts name: WOO JE LEE, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 37.566, lon: 126.9784, locations facility: The Catholic Univ. of Korea Seoul St. Mary's Hospital, status: NOT_YET_RECRUITING, city: Seoul, state: Seoul-teukbyeolsi [Seoul], zip: 06591, country: Korea, Republic of, contacts name: Kiyuk Chang, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 37.566, lon: 126.9784, locations facility: The Catholic Univ. of Korea Seoul St. Mary's Hospital, status: NOT_YET_RECRUITING, city: Seoul, state: Seoul-teukbyeolsi [Seoul], zip: 06591, country: Korea, Republic of, contacts name: Seung-Hwan Lee, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 37.566, lon: 126.9784, locations facility: Kyung Hee University Hospital at Gangdong, status: RECRUITING, city: Seoul, state: Seoul-teukbyeolsi [Seoul], zip: 134-090, country: Korea, Republic of, contacts name: In-Kyung Jeong, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 37.566, lon: 126.9784, locations facility: Daegu Catholic University Medical Center, status: NOT_YET_RECRUITING, city: Daegu, state: Taegu-Kwangyǒkshi, zip: 42472, country: Korea, Republic of, contacts name: SEUNGPYO HONG, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 35.87028, lon: 128.59111, locations facility: Keimyung University Dongsan Hospital, status: RECRUITING, city: Daegu, state: Taegu-Kwangyǒkshi, zip: 42601, country: Korea, Republic of, contacts name: Seung-Ho Hur, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 35.87028, lon: 128.59111, locations facility: Eulji University Hospital, status: NOT_YET_RECRUITING, city: Daejeon, state: Taejǒn-Kwangyǒkshi, zip: 01830, country: Korea, Republic of, contacts name: Jun-Hwa Hong, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 36.32139, lon: 127.41972, locations facility: Ulsan University Hospital, status: NOT_YET_RECRUITING, city: Ulsan, state: Ulsan-Kwangyǒkshi, zip: 44033, country: Korea, Republic of, contacts name: GYUNGMIN PARK, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 35.53722, lon: 129.31667, locations facility: Centro de Investigacion Cardiovascular y Metabólica, status: NOT_YET_RECRUITING, city: Tijuana, state: Baja California, zip: 22500, country: Mexico, contacts name: Pedro Fajardo Campos, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 32.5027, lon: -117.00371, locations facility: Centro Médico Nacional Siglo XXI, status: NOT_YET_RECRUITING, city: Ciudad de México, state: Distrito Federal, zip: 06720, country: Mexico, contacts name: Juan Ivey Miranda, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 19.42847, lon: -99.12766, locations facility: RM Pharma Specialists, status: NOT_YET_RECRUITING, city: Mexico City, state: Distrito Federal, zip: 03100, country: Mexico, contacts name: Mariana Zolandi Crespo, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 19.42847, lon: -99.12766, locations facility: Clínicos Asociados BOCM, status: NOT_YET_RECRUITING, city: Mexico City, state: Distrito Federal, zip: 03300, country: Mexico, contacts name: Israel Olvera-Alvarez, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 19.42847, lon: -99.12766, locations facility: Grupo Medico Camino Sc, status: NOT_YET_RECRUITING, city: Mexico City, state: Distrito Federal, zip: 03310, country: Mexico, contacts name: JORGE SIERRA, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 19.42847, lon: -99.12766, locations facility: Hospital de Jésus, I.A.P., status: NOT_YET_RECRUITING, city: Mexico City, state: Distrito Federal, zip: 06090, country: Mexico, contacts name: Efrain Villeda Espinosa, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 19.42847, lon: -99.12766, locations facility: Clinica Omega, status: NOT_YET_RECRUITING, city: Mexico City, state: Distrito Federal, zip: 06700, country: Mexico, contacts name: Jose Hector Sanchez Mijangos, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 19.42847, lon: -99.12766, locations facility: Centro Especializado En Diabetes, Obesidad Y Prevencion De Enfermedades Cardiovasculares, status: NOT_YET_RECRUITING, city: Mexico City, state: Distrito Federal, zip: 11650, country: Mexico, contacts name: Melchor Alpizar Salazar, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 19.42847, lon: -99.12766, locations facility: ProcliniQ Investigación Clínica SA de CV, status: NOT_YET_RECRUITING, city: Mexico City, state: Distrito Federal, zip: 14050, country: Mexico, contacts name: Mauricio Lopez Meneses, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 19.42847, lon: -99.12766, locations facility: Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, status: NOT_YET_RECRUITING, city: Mexico City, state: Distrito Federal, zip: 14080, country: Mexico, contacts name: Carlos Aguilar Salinas, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 19.42847, lon: -99.12766, locations facility: Clinstile, S.A. de C.V., status: NOT_YET_RECRUITING, city: Mexico, state: Distrito Federal, zip: 06700, country: Mexico, contacts name: Vicente Eduardo Ruiz Ruiz, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 19.42847, lon: -99.12766, locations facility: Medimanage Research, status: NOT_YET_RECRUITING, city: Tlalpan, state: Distrito Federal, zip: 14050, country: Mexico, contacts name: Nydia Avila-Vanzzini, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 19.29513, lon: -99.16206, locations facility: Instituto Cardiovascular de León S.C., status: NOT_YET_RECRUITING, city: León, state: Guanajuato, zip: 37520, country: Mexico, contacts name: Luis Adolfo Venegas Carrillo, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 21.12908, lon: -101.67374, locations facility: Instituto Jalisciense de Investigacion en Diabetes y Obesidad, status: NOT_YET_RECRUITING, city: Guadalajara, state: Jalisco, zip: 04460, country: Mexico, contacts name: Guillermo Gonzalez Galvez, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 20.66682, lon: -103.39182, locations facility: Diseno y Planeacion en Investigacion Medica, status: NOT_YET_RECRUITING, city: Guadalajara, state: Jalisco, zip: 44130, country: Mexico, contacts name: Cesar Calvo, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 20.66682, lon: -103.39182, locations facility: Centro de Investigacion Medica Integral, status: NOT_YET_RECRUITING, city: Guadalajara, state: Jalisco, zip: 44160, country: Mexico, contacts name: Carlos Alejandro Stobschinski de Alba, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 20.66682, lon: -103.39182, locations facility: Unidad de Investigación Clínica y Atención Médica HEPA, status: NOT_YET_RECRUITING, city: Guadalajara, state: Jalisco, zip: 44670, country: Mexico, contacts name: Marisol Herrera Marmolejo, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 20.66682, lon: -103.39182, locations facility: Virgen Cardiovascular Research SC, status: NOT_YET_RECRUITING, city: Guadalajara, state: Jalisco, zip: 44670, country: Mexico, contacts name: Luis Ramon Virgen Carrillo, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 20.66682, lon: -103.39182, locations facility: CINVEC Medica, status: NOT_YET_RECRUITING, city: Guadalajara, state: Jalisco, zip: 44690, country: Mexico, contacts name: Alejandro Avila Carrillo, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 20.66682, lon: -103.39182, locations facility: Clinica de Enfermedades Crónicas y de Procedimientos Especiales, status: NOT_YET_RECRUITING, city: Morelia, state: Michoacán, zip: 58249, country: Mexico, contacts name: Helios Vega, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 19.70078, lon: -101.18443, locations facility: Instituto de Diabetes, Obesidad y Nutricion, status: NOT_YET_RECRUITING, city: Cuernavaca, state: Morelos, zip: 62250, country: Mexico, contacts name: Leobardo Sauque Reyna, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 18.9261, lon: -99.23075, locations facility: CHRISTUS Centro de Excelencia en Investigación (Norte), status: NOT_YET_RECRUITING, city: General Escobedo, state: Nuevo León, zip: 66055, country: Mexico, contacts name: Ivan Rosendo Salinas Cavazos, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 25.79698, lon: -100.31791, locations facility: Accelerium Clinical Research, status: NOT_YET_RECRUITING, city: Monterrey, state: Nuevo León, zip: 64000, country: Mexico, contacts name: Eduardo Roderick Elizondo Moreno, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 25.67507, lon: -100.31847, locations facility: Cardiolink Clin Trials, status: NOT_YET_RECRUITING, city: Monterrey, state: Nuevo León, zip: 64060, country: Mexico, contacts name: Elías García, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 25.67507, lon: -100.31847, locations facility: Hospital Universitario "Dr. Jose Eleuterio Gonzalez", status: NOT_YET_RECRUITING, city: Monterrey, state: Nuevo León, zip: 64460, country: Mexico, contacts name: RAMIRO FLORES-RAMIREZ, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 25.67507, lon: -100.31847, locations facility: Hospital Universitario "Dr. Jose Eleuterio Gonzalez", status: NOT_YET_RECRUITING, city: Monterrey, state: Nuevo León, zip: 64460, country: Mexico, contacts name: Jose Gerardo Gonzalez Gonzalez, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 25.67507, lon: -100.31847, locations facility: Unidad biomedica avanzada monterrey, status: NOT_YET_RECRUITING, city: Monterrey, state: Nuevo León, zip: 64460, country: Mexico, contacts name: Raymundo Garcia Reza, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 25.67507, lon: -100.31847, locations facility: Clínica García Flores SC, status: NOT_YET_RECRUITING, city: Monterrey, state: Nuevo León, zip: 64610, country: Mexico, contacts name: Pedro Alberto Garcia, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 25.67507, lon: -100.31847, locations facility: Centro de investigación y control metabólico, status: NOT_YET_RECRUITING, city: Monterrey, state: Nuevo León, zip: 66465, country: Mexico, contacts name: Víctor Castelán Vargas, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 25.67507, lon: -100.31847, locations facility: Servicios Integrales Nova de Monterrey S.A. de C.V., status: NOT_YET_RECRUITING, city: San Nicolas de los Garza, state: Nuevo León, zip: 66450, country: Mexico, contacts name: Maria Elena Romero-Ibarguengoitia, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 25.74167, lon: -100.30222, locations facility: Centro de Investigacion Clinica de Oaxaca, status: NOT_YET_RECRUITING, city: Oaxaca de Juarez, state: Oaxaca, zip: 68020, country: Mexico, contacts name: Jesus Antonio Perez Ríos, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 17.06542, lon: -96.72365, locations facility: Centro Para El Desarrollo de La Medicina Y de Asistencia Medica Especializada S.C., status: NOT_YET_RECRUITING, city: Culiacan, state: Sinaloa, zip: 80230, country: Mexico, contacts name: Manuel Odin de los Rios Ibarra, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 24.79032, lon: -107.38782, locations facility: Investigación Médica Sonora, S.C., status: NOT_YET_RECRUITING, city: Hermosillo, state: Sonora, zip: 83270, country: Mexico, contacts name: Diego Espinoza Peralta, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 29.1026, lon: -110.97732, locations facility: Meander Medisch Centrum, status: NOT_YET_RECRUITING, city: Amersfoort, state: Utrecht, zip: 3813 TZ, country: Mexico, contacts name: Arend Mosterd, role: PRINCIPAL_INVESTIGATOR, locations facility: Hospital Angeles Xalapa, status: NOT_YET_RECRUITING, city: Xalapa, state: Veracruz, zip: 91193, country: Mexico, contacts name: Gustavo Mendez Machado, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 19.53124, lon: -96.91589, locations facility: Medical Care and Research SA de CV, status: NOT_YET_RECRUITING, city: Merida, state: Yucatán, zip: 97070, country: Mexico, contacts name: Christian Gonzalez, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 20.97537, lon: -89.61696, locations facility: Groene Hart Ziekenhuis, status: NOT_YET_RECRUITING, city: Gouda, state: Zuid-Holland, zip: 2803HH, country: Mexico, contacts name: Stefan Koudstaal, role: PRINCIPAL_INVESTIGATOR, locations facility: Centro de Investigación Cardiometabólica de Aguascalientes, status: NOT_YET_RECRUITING, city: Aguascalientes, zip: 20230, country: Mexico, contacts name: Enrique Cuitlahuac Morales-Villegas, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 21.88234, lon: -102.28259, locations facility: Fundación Cardiovascular de Aguascalientes A.C., status: NOT_YET_RECRUITING, city: Aguascalientes, zip: 20230, country: Mexico, contacts name: Edmundo Alfredo Bayram Llamas, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 21.88234, lon: -102.28259, locations facility: Hospital Cardiologica Aguescalientes, status: NOT_YET_RECRUITING, city: Aguascalientes, zip: 20230, country: Mexico, contacts name: Guillermo Antonio Llamas Esperon, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 21.88234, lon: -102.28259, locations facility: Enclifar Ensayos Clínicos Farmacológicos Sc, status: NOT_YET_RECRUITING, city: Chihuahua, zip: 31110, country: Mexico, contacts name: Luis Alejandro Nevarez, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 28.63528, lon: -106.08889, locations facility: Lahoja. Asociacion Para La Investigacion Y La Farmacovigilancia, status: NOT_YET_RECRUITING, city: Durango, zip: 34000, country: Mexico, contacts name: Juan Carlos Núñez Fragoso, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 24.02032, lon: -104.65756, locations facility: Centro de Estudios Clínicos de Querétaro (CECLIQ), status: NOT_YET_RECRUITING, city: Querétaro, zip: 76000, country: Mexico, contacts name: Marco Antonio Alcocer Gamba, role: PRINCIPAL_INVESTIGATOR, locations facility: PanAmerican Clinical Research - Querétaro - Avenida Antea, status: NOT_YET_RECRUITING, city: Querétaro, zip: 76100, country: Mexico, contacts name: Juan Villagordoa Mesa, role: PRINCIPAL_INVESTIGATOR, locations facility: Centro de Atención e Investigación Cardiovascular del Potosí, status: NOT_YET_RECRUITING, city: San Luis Potosí, zip: 78200, country: Mexico, contacts name: José Rivera Arellano, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 22.14982, lon: -100.97916, locations facility: Universitair Medisch Centrum Utrecht, status: NOT_YET_RECRUITING, city: Utrecht, zip: 3584 CX, country: Mexico, contacts name: Jannick Dorresteijn, role: PRINCIPAL_INVESTIGATOR, locations facility: Instituto Veracruzano en Investigación Clínica S.C., status: NOT_YET_RECRUITING, city: Veracruz, zip: 91851, country: Mexico, contacts name: Rosa Isela Luna Ceballos, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 19.18095, lon: -96.1429, locations facility: Medische Centrum Leeuwarden, status: NOT_YET_RECRUITING, city: Leeuwarden, state: Fryslân, zip: 8934 AD, country: Netherlands, contacts name: T. Vossenberg, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 53.20139, lon: 5.80859, locations facility: Antonius Ziekenhuis, locatie D&A Research and Genetics, status: NOT_YET_RECRUITING, city: Sneek, state: Fryslân, zip: 8601 ZR, country: Netherlands, contacts name: Renee Duitman, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 53.03297, lon: 5.6589, locations facility: Gelre Ziekenhuis, status: NOT_YET_RECRUITING, city: Apeldoorn, state: Gelderland, zip: 7334 DZ, country: Netherlands, contacts name: Bjorn Groenemeijer, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 52.21, lon: 5.96944, locations facility: Slingeland Ziekenhuis, status: NOT_YET_RECRUITING, city: Doetinchem, state: Gelderland, zip: 7009 BL, country: Netherlands, contacts name: Jeroen Jaspers Focks, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 51.965, lon: 6.28889, locations facility: Ziekenhuis Gelderse Vallei, status: NOT_YET_RECRUITING, city: Ede, state: Gelderland, zip: 6716 RP, country: Netherlands, contacts name: Thomas Oosterhof, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 52.03333, lon: 5.65833, locations facility: Ziekenhuis St. Jansdal, status: NOT_YET_RECRUITING, city: Harderwijk, state: Gelderland, zip: 3844 DG, country: Netherlands, contacts name: Marc van der Zee, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 52.34167, lon: 5.62083, locations facility: Radboudumc, status: NOT_YET_RECRUITING, city: Nijmegen, state: Gelderland, zip: 6525 GA, country: Netherlands, contacts name: Saloua El Messaoudi, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 51.8425, lon: 5.85278, locations facility: VieCuri Medisch Centrum, locatie Venlo, status: NOT_YET_RECRUITING, city: Venlo, state: Limburg, zip: 5912 BL, country: Netherlands, contacts name: Wouter Remkes, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 51.37, lon: 6.16806, locations facility: Jeroen Bosch ziekenhuis, status: NOT_YET_RECRUITING, city: Den Bosch, state: Noord-Brabant, zip: 5223 GZ, country: Netherlands, contacts name: Martijn van Eck, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 51.27, lon: 5.59167, locations facility: Catharina Ziekenhuis, status: NOT_YET_RECRUITING, city: Eindhoven, state: Noord-Brabant, zip: 5623 EJ, country: Netherlands, contacts name: Guus Brueren, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 51.44083, lon: 5.47778, locations facility: Bravis Ziekenhuis, locatie Roosendaal, status: NOT_YET_RECRUITING, city: Roosendaal, state: Noord-Brabant, zip: 4708 AE, country: Netherlands, contacts name: Reinhart Dorman, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 51.53083, lon: 4.46528, locations facility: ETZ TweeSteden, status: NOT_YET_RECRUITING, city: Tilburg, state: Noord-Brabant, zip: 5042 AD, country: Netherlands, contacts name: Pascalle Monraats, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 51.55551, lon: 5.0913, locations facility: Maxima Medisch Centrum, locatie Veldhoven, status: NOT_YET_RECRUITING, city: Veldhoven, state: Noord-Brabant, zip: 5504 DB, country: Netherlands, contacts name: Sabine Eijsbouts, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 51.41833, lon: 5.40278, locations facility: Onze Lieve Vrouwe Gasthuis, status: NOT_YET_RECRUITING, city: Amsterdam, state: Noord-Holland, zip: 1091 AC, country: Netherlands, contacts name: Ton Slagboom, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 52.37403, lon: 4.88969, locations facility: Amsterdam UMC, locatie AMC, status: NOT_YET_RECRUITING, city: Amsterdam, state: Noord-Holland, zip: 1105 AZ, country: Netherlands, contacts name: Erik Stroes, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 52.37403, lon: 4.88969, locations facility: Rode Kruis Ziekenhuis, status: NOT_YET_RECRUITING, city: Beverwijk, state: Noord-Holland, zip: 1942 LE, country: Netherlands, contacts name: Iris Westendorp, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 52.48333, lon: 4.65694, locations facility: Spaarne Gasthuis, Haarlem Zuid, status: NOT_YET_RECRUITING, city: Haarlem, state: Noord-Holland, zip: 2035 RC, country: Netherlands, contacts name: Aaf Kuijper, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 52.38084, lon: 4.63683, locations facility: Tergooiziekenhuizen, locatie Hilversum, status: NOT_YET_RECRUITING, city: Hilversum, state: Noord-Holland, zip: 1212 VG, country: Netherlands, contacts name: Pieter Kamphuisen, role: SUB_INVESTIGATOR, geoPoint lat: 52.22333, lon: 5.17639, locations facility: Zaans Medisch Centrum, status: NOT_YET_RECRUITING, city: Zaandam, state: Noord-Holland, zip: 1502 DV, country: Netherlands, contacts name: P.A. Dijkmans, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 52.43854, lon: 4.82643, locations facility: Deventer Ziekenhuis, status: NOT_YET_RECRUITING, city: Deventer, state: Overijssel, zip: 7416 SE, country: Netherlands, contacts name: Elsemiek Engbers, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 52.255, lon: 6.16389, locations facility: Saxenburgh Medisch Centrum, status: NOT_YET_RECRUITING, city: Hardenberg, state: Overijssel, zip: 7772 SE, country: Netherlands, contacts name: Bas Bemmel, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 52.57583, lon: 6.61944, locations facility: Admiraal de Ruyter Ziekenhuis, locatie Goes, status: NOT_YET_RECRUITING, city: Goes, state: Zeeland, zip: 4462 RA, country: Netherlands, contacts name: Fesile Basar, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 51.50417, lon: 3.88889, locations facility: Reinier de Graaf Ziekenhuis, locatie Delft, status: NOT_YET_RECRUITING, city: Delft, state: Zuid-Holland, zip: 2625 AD, country: Netherlands, contacts name: Jan Constandse, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 52.00667, lon: 4.35556, locations facility: Haga Ziekenhuis locatie Leyweg, status: NOT_YET_RECRUITING, city: Den Haag, state: Zuid-Holland, zip: 2545 AA, country: Netherlands, contacts name: Albert Mairuhu, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 52.07667, lon: 4.29861, locations facility: Leids Universitair Medisch Centrum, status: NOT_YET_RECRUITING, city: Leiden, state: Zuid-Holland, zip: 2333 ZA, country: Netherlands, contacts name: Wouter Jukema, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 52.15833, lon: 4.49306, locations facility: Erasmus Medisch Centrum, status: NOT_YET_RECRUITING, city: Rotterdam, state: Zuid-Holland, zip: 3015 GD, country: Netherlands, contacts name: Jeanine Roeters van Lennep, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 51.9225, lon: 4.47917, locations facility: Ikazia Ziekenhuis, status: NOT_YET_RECRUITING, city: Rotterdam, state: Zuid-Holland, zip: 3083 AN, country: Netherlands, contacts name: Mireille Emans, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 51.9225, lon: 4.47917, locations facility: General Practitioners Research Institute (GPRI), status: NOT_YET_RECRUITING, city: Groningen, zip: 9713 GH, country: Netherlands, contacts name: Janwillem WH Kocks, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 53.21917, lon: 6.56667, locations facility: Martini Ziekenhuis, status: NOT_YET_RECRUITING, city: Groningen, zip: 9728 NT, country: Netherlands, contacts name: G.L. Bartels, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 53.21917, lon: 6.56667, locations facility: 4 Wojskowy Szpital Kliniczny z Polikliniką SPZOZ, status: NOT_YET_RECRUITING, city: Wrocław, state: Dolnośląskie, zip: 50-981, country: Poland, contacts name: Bartosz Krakowiak, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 51.1, lon: 17.03333, locations facility: NZOZ Centurm Medyczne SERAFIN-MED, status: NOT_YET_RECRUITING, city: Zarow, state: Dolnośląskie, zip: 58-130, country: Poland, contacts name: Ryszard Serafin, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 50.94116, lon: 16.49466, locations facility: NZOZ Centrum Medyczne KERmed, status: NOT_YET_RECRUITING, city: Bydgoszcz, state: Kujawsko-pomorskie, zip: 85-231, country: Poland, contacts name: Tomasz Lugowski, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 53.1235, lon: 18.00762, locations facility: INTERCOR, status: NOT_YET_RECRUITING, city: Bydgoszcz, state: Kujawsko-pomorskie, zip: 85-605, country: Poland, contacts name: Grzegorz Grzesk, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 53.1235, lon: 18.00762, locations facility: Euromedica, status: NOT_YET_RECRUITING, city: Grudziadz, state: Kujawsko-pomorskie, zip: 86-300, country: Poland, contacts name: Piotr Kubalski, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 53.48411, lon: 18.75366, locations facility: 1 Wojskowy Szpital Kliniczny w Lublinie, status: NOT_YET_RECRUITING, city: Lublin, state: Lubelskie, zip: 20-043, country: Poland, contacts name: Grzegorz Sobieszek, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 51.25, lon: 22.56667, locations facility: CenterMed Lublin NZOZ, status: NOT_YET_RECRUITING, city: Lublin, state: Lubelskie, zip: 20-044, country: Poland, contacts name: Grzegorz Drelich, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 51.25, lon: 22.56667, locations facility: Private Practice - Dr. Michał Tomaszewski, status: NOT_YET_RECRUITING, city: Lublin, state: Lubelskie, zip: 20-068, country: Poland, contacts name: Michal Tomaszewski, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 51.25, lon: 22.56667, locations facility: Clinical Best Solutions, status: NOT_YET_RECRUITING, city: Lublin, state: Lubelskie, zip: 20-078, country: Poland, contacts name: MARZENA JANIK-PALAZZOLO, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 51.25, lon: 22.56667, locations facility: Wielospecjalistyczny Szpital Samodzielny Publiczny Zakład Opieki Zdrowotnej w Nowej Soli, status: NOT_YET_RECRUITING, city: Nowa Sol, state: Lubuskie, zip: 67-100, country: Poland, contacts name: Jaroslaw Hiczkiewicz, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 51.80333, lon: 15.71702, locations facility: WIP Warsaw IBD Point Profesor Kierkus, status: NOT_YET_RECRUITING, city: Warsaw, state: Mazowieckie, zip: 00-728, country: Poland, contacts name: Agata Krzesiak-Lodyga, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 52.22977, lon: 21.01178, locations facility: Balsam Medica, status: NOT_YET_RECRUITING, city: Warsaw, state: Mazowieckie, zip: 01-249, country: Poland, contacts name: Marcin Grabowski, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 52.22977, lon: 21.01178, locations facility: Clinical Best Solutions, status: NOT_YET_RECRUITING, city: Warszawa, state: Mazowieckie, zip: 00-710, country: Poland, contacts name: Joanna Niegowska, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 52.22977, lon: 21.01178, locations facility: Polsko-Amerykańskie Kliniki Serca PAKS Małopolskie Centrum Sercowo-Naczyniowe, status: NOT_YET_RECRUITING, city: Chrzanow, state: Małopolskie, zip: 32-500, country: Poland, contacts name: Aleksander Zurakowski, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 50.13546, lon: 19.40203, locations facility: Centrum Medyczne Linden, status: NOT_YET_RECRUITING, city: Krakow, state: Małopolskie, zip: 30-721, country: Poland, contacts name: Beata Maria Bobrowska, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 50.06143, lon: 19.93658, locations facility: NZOZ Diab-Endo-Met, status: NOT_YET_RECRUITING, city: Krakow, state: Małopolskie, zip: 31-261, country: Poland, contacts name: Magdalena Kwiatkowska, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 50.06143, lon: 19.93658, locations facility: Centrum Szybkiej Diagnostyki Kardiologicznej "Kardiomed" M. Żabówka E. Żabówka, status: NOT_YET_RECRUITING, city: Tarnow, state: Małopolskie, zip: 33-100, country: Poland, contacts name: Maciej Stanislaw Zabowka, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 50.01381, lon: 20.98698, locations facility: Polsko-Amerykańskie Kliniki Serca, status: NOT_YET_RECRUITING, city: Kedzierzyn-Kozle, state: Opolskie, zip: 47-200, country: Poland, contacts name: Janusz Prokopczuk, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 50.34984, lon: 18.22606, locations facility: Wojewodzki Szpital im. Sw. Ojca Pio w Przemyslu, status: NOT_YET_RECRUITING, city: Przemysl, state: Podkarpackie, zip: 37-700, country: Poland, contacts name: Lukasz Wisniowski, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 49.78498, lon: 22.76728, locations facility: Specderm Poznanska, status: NOT_YET_RECRUITING, city: Bialystok, state: Podlaskie, zip: 15-375, country: Poland, contacts name: Katarzyna Ptaszynska, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 53.13333, lon: 23.16433, locations facility: Uniwersyteckie Centrum Kliniczne, status: NOT_YET_RECRUITING, city: Gdańsk, state: Pomorskie, zip: 80-952, country: Poland, contacts name: Agnieszka Mickiewicz, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 54.35205, lon: 18.64637, locations facility: Centrum Kliniczno-Badawcze, status: NOT_YET_RECRUITING, city: Elblag, state: Warmińsko-mazurskie, zip: 82-300, country: Poland, contacts name: Bozena Gornikiewicz-Brzezicka, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 54.1522, lon: 19.40884, locations facility: NZOZ TwojeZdrowie, status: NOT_YET_RECRUITING, city: Elblag, state: Warmińsko-mazurskie, zip: 82-300, country: Poland, contacts name: Waldemar Bieniek, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 54.1522, lon: 19.40884, locations facility: Poliklinika Kardiologiczna Serce, status: NOT_YET_RECRUITING, city: Leszno, state: Wielkopolskie, zip: 64-100, country: Poland, contacts name: Witold Piotrowski, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 51.84034, lon: 16.57494, locations facility: Centra Medyczne Medyceusz, status: NOT_YET_RECRUITING, city: Lodz, state: Łódzkie, zip: 91-053, country: Poland, contacts name: Wlodzimierz Kus, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 51.75, lon: 19.46667, locations facility: Pro Salus Centrum Medyczne, status: NOT_YET_RECRUITING, city: Lodz, state: Łódzkie, zip: 91-473, country: Poland, contacts name: Marcin Ojrzanowski, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 51.75, lon: 19.46667, locations facility: Wojewodzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im. M. Kopernika w Lodzi, status: NOT_YET_RECRUITING, city: Łódź, state: Łódzkie, zip: 93-513, country: Poland, contacts name: Grzegorz Piotrowski, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 51.75, lon: 19.46667, locations facility: Polsko-Amerykańskie Kliniki Serca II Oddział Kardiologiczny, status: NOT_YET_RECRUITING, city: Bielsko-Biala, state: Śląskie, zip: 43-300, country: Poland, contacts name: Krzysztof Milewski, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 49.82245, lon: 19.04686, locations facility: Polsko-Amerykańskie Kliniki Serca, status: NOT_YET_RECRUITING, city: Dabrowa Gornicza, state: Śląskie, zip: 41-300, country: Poland, contacts name: Katarzyna Szymczyk, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 50.31818, lon: 19.2374, locations facility: NZOZ Salvia CM, status: NOT_YET_RECRUITING, city: Katowice, state: Śląskie, zip: 40-772, country: Poland, contacts name: Andrzej Madej, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 50.25841, lon: 19.02754, locations facility: AKA-MED Centrum, status: NOT_YET_RECRUITING, city: Ruda Slaska, state: Śląskie, zip: 41-710, country: Poland, contacts name: Janusz Spyra, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 50.2584, lon: 18.85632, locations facility: Polsko-Amerykańskie Kliniki Serca, status: NOT_YET_RECRUITING, city: Tychy, state: Śląskie, zip: 43-100, country: Poland, contacts name: Adam Janas, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 50.13717, lon: 18.96641, locations facility: Advanced Clinical Research, LLC, status: RECRUITING, city: Bayamón, zip: 00959, country: Puerto Rico, contacts name: Angel Comulada-Rivera, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 18.39856, lon: -66.15572, locations facility: GCM Medical Group, PSC - Hato Rey Site, status: RECRUITING, city: San Juan, zip: 00917, country: Puerto Rico, contacts name: Gregorio Cortes-Maisonet, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 18.46633, lon: -66.10572, locations facility: Nicodiab, status: NOT_YET_RECRUITING, city: Bucharest, state: București, zip: 010507, country: Romania, contacts name: NICOLETA MINDRESCU, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 44.43225, lon: 26.10626, locations facility: Hightech Medical Services SRL-Centrul pentru Studiul Metabolismului, status: RECRUITING, city: Bucharest, state: București, zip: 011053, country: Romania, contacts name: Ciprian Constantin, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 44.43225, lon: 26.10626, locations facility: Centrul Medical NutriLife, status: RECRUITING, city: Bucharest, state: București, zip: 013764, country: Romania, contacts name: Marlena Pascu, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 44.43225, lon: 26.10626, locations facility: Centrul Medical Endocrinologie si Diabet Dr. Paveliu, status: RECRUITING, city: Bucharest, state: București, zip: 50538, country: Romania, contacts name: Fraga Paveliu, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 44.43225, lon: 26.10626, locations facility: Mat Cord Biomedica S.R.L., status: NOT_YET_RECRUITING, city: Buzau, state: Buzău, country: Romania, contacts name: Florin Lucian Matei, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 45.15, lon: 26.83333, locations facility: Spitalul Clinic Județean de Urgență, status: NOT_YET_RECRUITING, city: Craiova, state: Dolj, zip: 200642, country: Romania, contacts name: Octavian Istratoaie, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 44.31667, lon: 23.8, locations facility: Private Practice - Dr. Mercea Corina Delia, status: NOT_YET_RECRUITING, city: Baia Mare, state: Maramureș, zip: 430123, country: Romania, contacts name: DELIA MERCEA, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 47.65529, lon: 23.57381, locations facility: CMI DNBM Dr. Pop Lavinia, status: RECRUITING, city: Baia Mare, state: Maramureș, zip: 430222, country: Romania, contacts name: Lavinia Pop, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 47.65529, lon: 23.57381, locations facility: SC Dentosim Queen SRL - Centrul Medical Diamed, status: RECRUITING, city: Târgu Mureș, state: Mureș, zip: 540098, country: Romania, contacts name: Daniela Ciomos, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 46.54245, lon: 24.55747, locations facility: Cardiomed, status: NOT_YET_RECRUITING, city: Târgu Mureș, state: Mureș, zip: 540124, country: Romania, contacts name: Imre Benedek, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 46.54245, lon: 24.55747, locations facility: Centrul Medical Mediab, status: NOT_YET_RECRUITING, city: Târgu-Mureș, state: Mureș, zip: 540142, country: Romania, contacts name: Carmen Crisan, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 46.54245, lon: 24.55747, locations facility: Centrul Medical Mediab, status: NOT_YET_RECRUITING, city: Târgu-Mureș, state: Mureș, zip: 540142, country: Romania, contacts name: Adriana Cif, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 46.54245, lon: 24.55747, locations facility: Private Practice - Dr. Cristian Podoleanu, status: NOT_YET_RECRUITING, city: Târgu-Mureș, state: Mureș, zip: 540143, country: Romania, contacts name: Cristian Podoleanu, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 46.54245, lon: 24.55747, locations facility: Cabinet Medical Dr.Geru, status: RECRUITING, city: Timisoara, state: Timiș, zip: 300288, country: Romania, contacts name: Polina Geru, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 45.75372, lon: 21.22571, locations facility: Institutul de Boli Cardiovasculare Timișoara, status: NOT_YET_RECRUITING, city: Timișoara, state: Timiș, zip: 300310, country: Romania, contacts name: Dan Gaita, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 45.75372, lon: 21.22571, locations facility: C.M.D.T.A. Neomed, status: NOT_YET_RECRUITING, city: Brasov, zip: 500283, country: Romania, contacts name: Sanziana Barbulescu, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 45.64861, lon: 25.60613, locations facility: Spitalul Universitar de Urgență București, status: NOT_YET_RECRUITING, city: București, zip: 050098, country: Romania, contacts name: DRAGOS VINEREANU, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 44.42802, lon: 26.09665, locations facility: Milena Sante, status: RECRUITING, city: Galați, zip: 800001, country: Romania, contacts name: Cristina-Victoria Mistodie, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 45.45, lon: 28.05, locations facility: Diamed Obesity, status: RECRUITING, city: Galați, zip: 800291, country: Romania, contacts name: Magdalena Morosanu, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 45.45, lon: 28.05, locations facility: Centrul Medical Consultmed, status: NOT_YET_RECRUITING, city: Iași, zip: 700547, country: Romania, contacts name: Delia Reurean-Pintilei, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 47.16667, lon: 27.6, locations facility: Cardiomed Iași, status: NOT_YET_RECRUITING, city: Iași, zip: 700687, country: Romania, contacts name: Sirona Lupu, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 47.16667, lon: 27.6, locations facility: Clinica Korall, status: RECRUITING, city: Satu Mare, zip: 440055, country: Romania, contacts name: Adriana Filimon, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 47.79926, lon: 22.86255, locations facility: Policlinica Astra Sibiu, status: RECRUITING, city: Sibiu, zip: 550371, country: Romania, contacts name: Georgiana Nicolescu, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 45.8, lon: 24.15, locations facility: IN-DIA, status: NOT_YET_RECRUITING, city: Lucenec, state: Banskobystrický Kraj, zip: 984 01, country: Slovakia, contacts name: Livia Tomasova, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 48.33249, lon: 19.66708, locations facility: ENRIN, s.r.o., status: NOT_YET_RECRUITING, city: Rimavská Sobota, state: Banskobystrický Kraj, zip: 979 01, country: Slovakia, contacts name: Jana Horvath Bercikova, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 48.38284, lon: 20.02239, locations facility: Cliniq s.r.o., status: NOT_YET_RECRUITING, city: Bratislava, state: Bratislavský Kraj, zip: 81109, country: Slovakia, contacts name: Alena Ftacnikova, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 48.14816, lon: 17.10674, locations facility: Sin Azucar, status: NOT_YET_RECRUITING, city: Malacky, state: Bratislavský Kraj, zip: 901 01, country: Slovakia, contacts name: Barbora Zobokova, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 48.43604, lon: 17.02188, locations facility: Human Care s.r.o., status: NOT_YET_RECRUITING, city: Kosice, state: Košický Kraj, zip: 04001, country: Slovakia, contacts name: Viera Donicova, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 48.71395, lon: 21.25808, locations facility: Tatratrial s.r.o., status: NOT_YET_RECRUITING, city: Rožňava, state: Košický Kraj, zip: 04801, country: Slovakia, contacts name: Beata Lachova, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 48.66009, lon: 20.53758, locations facility: Areteus s.r.o., status: NOT_YET_RECRUITING, city: Trebisov, state: Košický Kraj, zip: 075 01, country: Slovakia, contacts name: Dasa Skripova, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 48.62858, lon: 21.71954, locations facility: Fakultná nemocnica Nitra, status: NOT_YET_RECRUITING, city: Nitra, state: Nitriansky Kraj, zip: 950 01, country: Slovakia, contacts name: Peter Minarik, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 48.30763, lon: 18.08453, locations facility: IMCORE, status: NOT_YET_RECRUITING, city: Presov, state: Prešovský Kraj, zip: 080 01, country: Slovakia, contacts name: Luboslava Kocurova Frajtova, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 48.99839, lon: 21.23393, locations facility: MEDISPOL, status: NOT_YET_RECRUITING, city: Presov, state: Prešovský Kraj, zip: 080 01, country: Slovakia, contacts name: Daniela Vinanska, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 48.99839, lon: 21.23393, locations facility: MEDIKALS, status: NOT_YET_RECRUITING, city: Piešťany, state: Trnavský Kraj, zip: 921 01, country: Slovakia, contacts name: Slavka Kalinova, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 48.59479, lon: 17.82591, locations facility: ENDIAMED s.r.o, status: RECRUITING, city: Dolny Kubin, state: Žilinský Kraj, zip: 026 01, country: Slovakia, contacts name: Jan Truban, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 49.20983, lon: 19.30341, locations facility: JM-Interna s.r.o, status: NOT_YET_RECRUITING, city: Dolny Kubin, state: Žilinský Kraj, zip: 02601, country: Slovakia, contacts name: Jan Micik, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 49.20983, lon: 19.30341, locations facility: NEDÚ - Národný endokrinologický a diabetologický ústav n.o., status: NOT_YET_RECRUITING, city: Lubochna, state: Žilinský Kraj, zip: 034 91, country: Slovakia, contacts name: Emil Martinka, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 49.12011, lon: 19.16891, locations facility: AMBORA s.r.o. Interna ambulancia, status: NOT_YET_RECRUITING, city: Martin, state: Žilinský Kraj, zip: 036 01, country: Slovakia, contacts name: Boris Raska, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 49.06651, lon: 18.92399, locations facility: MediPrax, s.r.o., status: NOT_YET_RECRUITING, city: Trstena, state: Žilinský Kraj, zip: 028 01, country: Slovakia, contacts name: Ivana Škerdová, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 49.36101, lon: 19.61249, locations facility: CHUAC-Complejo Hospitalario Universitario A Coruña, status: NOT_YET_RECRUITING, city: A Coruña, state: A Coruña [La Coruña], zip: 15001, country: Spain, contacts name: Jose Luis Diaz Diaz, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 43.37135, lon: -8.396, locations facility: Complejo Hospitalario Universitario de Ferrol (CHUF)- Hospital Naval, status: NOT_YET_RECRUITING, city: Ferrol, state: A Coruña [La Coruña], zip: 15405, country: Spain, contacts name: DIEGO BELLIDO GUERRERO, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 43.4896, lon: -8.21942, locations facility: CHUS - Hospital Clinico Universitario, status: NOT_YET_RECRUITING, city: Santiago de Compostela, state: A Coruña [La Coruña], zip: 15706, country: Spain, contacts name: Jose Ramon Gonzalez-Juanatey, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 42.88052, lon: -8.54569, locations facility: Hospital de Denia Marina Salud, status: NOT_YET_RECRUITING, city: Dénia, state: Alicante, zip: 03700, country: Spain, contacts name: ALFONSO VALLE, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 38.84078, lon: 0.10574, locations facility: Hospital Universitario Reina Sofia, status: NOT_YET_RECRUITING, city: Cordoba, state: Andalucía, zip: 14004, country: Spain, contacts name: Jose Lopez Miranda, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 37.89155, lon: -4.77275, locations facility: Hospital Unviersitario Virgen Nieves, status: NOT_YET_RECRUITING, city: Granada, state: Andalucía, zip: 18014, country: Spain, contacts name: Pablo González Bustos, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 37.18817, lon: -3.60667, locations facility: Hospital Universitario Virgen de la Victoria, status: NOT_YET_RECRUITING, city: Malaga, state: Andalucía, zip: 29010, country: Spain, contacts name: Francisco Tinahones Madueno, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 36.72016, lon: -4.42034, locations facility: Hospital de Cabueñes, status: NOT_YET_RECRUITING, city: Gijón, state: Asturias, zip: 33394, country: Spain, contacts name: Juan Rondán, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 43.53573, lon: -5.66152, locations facility: Hospital Universitari Son Espases, status: NOT_YET_RECRUITING, city: Palma, state: Balears [Baleares], zip: 07120, country: Spain, contacts name: Santiago Tofe Povedano, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 39.56939, lon: 2.65024, locations facility: Hospital Germans Trias i Pujol, status: NOT_YET_RECRUITING, city: Badalona, state: Barcelona [Barcelona], zip: 08916, country: Spain, contacts name: Núria Alonso Pedrol, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 41.45004, lon: 2.24741, locations facility: Parc de Salut Mar - Hospital del Mar, status: NOT_YET_RECRUITING, city: Barcelona, state: Barcelona [Barcelona], zip: 08003, country: Spain, contacts name: Miguel Achirica, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 41.38879, lon: 2.15899, locations facility: Hospital Universitario Marqués de Valdecilla, status: NOT_YET_RECRUITING, city: Santander, state: Cantabria, zip: 39008, country: Spain, contacts name: Marta Martin Millan, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 43.46472, lon: -3.80444, locations facility: Hospital Clínic de Barcelona, status: NOT_YET_RECRUITING, city: Barcelona, state: Catalunya [Cataluña], zip: 08036, country: Spain, contacts name: RAMON ESTRUCH, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 41.38879, lon: 2.15899, locations facility: Hospital de la Santa Creu i Sant Pau, status: NOT_YET_RECRUITING, city: Barcelona, state: Catalunya [Cataluña], zip: 08041, country: Spain, contacts name: Xavier Garcia-Moll, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 41.38879, lon: 2.15899, locations facility: Hospital Universitari de Bellvitge, status: NOT_YET_RECRUITING, city: L'Hospitalet de Llobregat, state: Catalunya [Cataluña], zip: 08907, country: Spain, contacts name: Xavier Pintó, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 41.35967, lon: 2.10028, locations facility: Consorci Sanitari Integral. Hospital Moisés Broggi, Sant Joan Despí, status: NOT_YET_RECRUITING, city: Sant Joan Despí, state: Catalunya [Cataluña], zip: 08970, country: Spain, contacts name: CARLOS JERICO ALBA, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 41.36718, lon: 2.0574, locations facility: Hospital Virgen del Camino, status: NOT_YET_RECRUITING, city: Sanlúcar de Barrameda, state: Cádiz, zip: 11540, country: Spain, contacts name: Manuel Beltran Robles, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 36.77808, lon: -6.3515, locations facility: Hospital Virgen de las Montañas, status: NOT_YET_RECRUITING, city: Villamartin, state: Cádiz, zip: 11650, country: Spain, contacts name: Enrique Garcia del Rio, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 36.85979, lon: -5.64485, locations facility: Hospital Universitari de Girona Doctor Josep Trueta, status: NOT_YET_RECRUITING, city: Girona, state: Girona [Gerona], zip: 17007, country: Spain, contacts name: Eduardo Esteve, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 41.98311, lon: 2.82493, locations facility: Hospital Insular de Gran Canaria, status: NOT_YET_RECRUITING, city: Las Palmas de Gran Canaria, state: Las Palmas, zip: 35016, country: Spain, contacts name: Rosa María Sánchez Hernández, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 28.09973, lon: -15.41343, locations facility: Hospital Universitario Fundacion ALcorcon, status: NOT_YET_RECRUITING, city: Alcorcón, state: Madrid, Comunidad De, zip: 28922, country: Spain, contacts name: Carlos Guijarro Herraiz, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 40.34582, lon: -3.82487, locations facility: Hospital Universitario Ramón y Cajal, status: NOT_YET_RECRUITING, city: Madrid, state: Madrid, Comunidad De, zip: 28034, country: Spain, contacts name: Luis Manzano Espinosa, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 40.4165, lon: -3.70256, locations facility: Hospital Universitario Puerta de Hierro Majadahonda, status: NOT_YET_RECRUITING, city: Majadahonda, state: Madrid, Comunidad De, zip: 28220, country: Spain, contacts name: Juan Manuel Escudier Villa, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 40.47353, lon: -3.87182, locations facility: Hospital Universitario Quironsalud Madrid, status: NOT_YET_RECRUITING, city: Pozuelo de Alarcón, state: Madrid, zip: 28223, country: Spain, contacts name: Esteban Jodar Gimeno, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 40.43293, lon: -3.81338, locations facility: Hospital Clínico Universitario Virgen de la Arrixaca, status: NOT_YET_RECRUITING, city: El Palmar, Murcia, state: Murcia, Región De, zip: 30120, country: Spain, contacts name: Domingo Pascual Figal, role: PRINCIPAL_INVESTIGATOR, locations facility: Vithas Hospital Sevilla, status: RECRUITING, city: Seville, state: Sevilla, zip: 41950, country: Spain, contacts name: Cristobal Morales Portillo, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 37.38283, lon: -5.97317, locations facility: Hospital Universitari Sant Joan de Reus, status: NOT_YET_RECRUITING, city: Reus, state: Tarragona [Tarragona], zip: 43204, country: Spain, contacts name: Daiana Ibarretxe Gerediaga, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 41.15612, lon: 1.10687, locations facility: Hospital Clinico de Valencia, status: NOT_YET_RECRUITING, city: Valencia, state: Valenciana, Comunitat, zip: 46010, country: Spain, contacts name: Julio Nunez Villota, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 39.46975, lon: -0.37739, locations facility: Hospital Arnau de Vilanova, status: NOT_YET_RECRUITING, city: Valencia, state: Valenciana, Comunitat, zip: 46015, country: Spain, contacts name: JUAN COSIN SALES, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 39.46975, lon: -0.37739, locations facility: Hospital General Universitario de Valencia, status: NOT_YET_RECRUITING, city: Valencia, state: València, zip: 46014, country: Spain, contacts name: Francesc Puchades, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 39.46975, lon: -0.37739, locations facility: Hospital Infanta Elena, status: NOT_YET_RECRUITING, city: Huelva, zip: 21007, country: Spain, contacts name: Manuel Jesús Romero-Jiménez, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 37.26638, lon: -6.94004, locations facility: Complejo Hospitalario de Jaén, status: NOT_YET_RECRUITING, city: Jaén, zip: 23007, country: Spain, contacts name: Francisco Gomez Delgado, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 37.76922, lon: -3.79028, locations facility: Hospital Lucus Augusti, status: NOT_YET_RECRUITING, city: Lugo, zip: 27003, country: Spain, contacts name: Rosa Argüeso Armesto, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 43.00992, lon: -7.55602, locations facility: Hospital Universitario La Paz, status: NOT_YET_RECRUITING, city: Madrid, zip: 28029, country: Spain, contacts name: Jose Mostaza, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 40.4165, lon: -3.70256, locations facility: Hospital Clinico San Carlos, status: NOT_YET_RECRUITING, city: Madrid, zip: 28040, country: Spain, contacts name: Manuel Mendez, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 40.4165, lon: -3.70256, locations facility: Hospital Universitario 12 de Octubre, status: NOT_YET_RECRUITING, city: Madrid, zip: 28041, country: Spain, contacts name: Agustin Blanco Echevarria, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 40.4165, lon: -3.70256, locations facility: Hospital Universitario de Salamanca - Complejo Asistencial Universitario de Salamanca, status: NOT_YET_RECRUITING, city: Salamanca, zip: 37007, country: Spain, contacts name: ARMANDO OTERINO MANZANAS, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 40.96882, lon: -5.66388, locations facility: Hospital General de Segovia, status: NOT_YET_RECRUITING, city: Segovia, zip: 40002, country: Spain, contacts name: FERNANDO Gomez PERALTA, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 40.94808, lon: -4.11839, locations facility: Hospital Universitario Virgen Macarena, status: NOT_YET_RECRUITING, city: Sevilla, zip: 41009, country: Spain, contacts name: Rafael Jesús Hidalgo Urbano, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 37.38283, lon: -5.97317, locations facility: Hospital Universitario Virgen Del Rocio, status: NOT_YET_RECRUITING, city: Sevilla, zip: 41013, country: Spain, contacts name: Luis Beltrán, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 37.38283, lon: -5.97317, locations facility: Hospital Universitario Miguel Servet, status: NOT_YET_RECRUITING, city: Zaragoza, zip: 50009, country: Spain, contacts name: Fernando Civeira, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 41.65606, lon: -0.87734, locations facility: Changhua Christian Hospital, status: NOT_YET_RECRUITING, city: Changhua County, state: Changhua, zip: 50006, country: Taiwan, contacts name: Ching-Pei Chen, role: PRINCIPAL_INVESTIGATOR, locations facility: Chang Gung Memorial Hospital at Kaohsiung, status: NOT_YET_RECRUITING, city: Kaohsiung Niao Sung Dist, state: Kaohsiung, zip: 83301, country: Taiwan, contacts name: Chih-Yuan Fang, role: PRINCIPAL_INVESTIGATOR, locations facility: Chung Shan Medical University Hospital, status: NOT_YET_RECRUITING, city: Taichung City, state: Taichung, zip: 402, country: Taiwan, contacts name: Kwo-Chang Ueng, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 24.1469, lon: 120.6839, locations facility: Chi Mei Medical Center, status: NOT_YET_RECRUITING, city: Tainan City, state: Tainan, zip: 71004, country: Taiwan, contacts name: Chon Seng Hong, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 22.99083, lon: 120.21333, locations facility: Cathay General Hospital, status: NOT_YET_RECRUITING, city: Taipei City, state: Taipei, zip: 106, country: Taiwan, contacts name: Chi-Hung Huang, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 25.04776, lon: 121.53185, locations facility: Shin Kong Wu Ho-Su Memorial Hospital, status: NOT_YET_RECRUITING, city: Taipei City, state: Taipei, zip: 111, country: Taiwan, contacts name: Kou-Gi Shyu, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 25.04776, lon: 121.53185, locations facility: Tri-Service General Hospital, status: NOT_YET_RECRUITING, city: Taipei City, state: Taipei, zip: 114, country: Taiwan, contacts name: WEI-HSIANG LIN, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 25.04776, lon: 121.53185, locations facility: National Yang Ming Chiao Tung University Hospital, status: NOT_YET_RECRUITING, city: Yilan City, state: Yilan, zip: 260006, country: Taiwan, contacts name: Hsuan-Ming Tsao, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 24.757, lon: 121.753, locations facility: Kaohsiung Medical University Chung-Ho Memorial Hospital, status: RECRUITING, city: Kaohsiung, zip: 807, country: Taiwan, contacts name: Tsung-Hsien Lin, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 22.61626, lon: 120.31333, locations facility: Fu Jen Catholic University Hospital, status: NOT_YET_RECRUITING, city: New Taipei, zip: 24352, country: Taiwan, contacts name: Shih-Chi Liu, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 25.01111, lon: 121.44583, locations facility: National Cheng Kung University Hospital, status: NOT_YET_RECRUITING, city: Tainan, zip: 704, country: Taiwan, contacts name: Yi-Ching Yang, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 22.99083, lon: 120.21333, locations facility: National Taiwan University Hospital, status: NOT_YET_RECRUITING, city: Taipei, zip: 10002, country: Taiwan, contacts name: Tzung-Dau Wang, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 25.04776, lon: 121.53185, locations facility: Taipei Medical University Hospital, status: NOT_YET_RECRUITING, city: Taipei, zip: 110, country: Taiwan, contacts name: Chun-Yao Huang, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 25.04776, lon: 121.53185, locations facility: Taipei Veterans General Hospital, status: NOT_YET_RECRUITING, city: Taipei, zip: 11217, country: Taiwan, contacts name: Chern-En Chiang, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 25.04776, lon: 121.53185, locations facility: Chang Gung Medical Foundation-Linkou Branch, status: NOT_YET_RECRUITING, city: Taoyuan, zip: 333, country: Taiwan, contacts name: Pao-Hsien Pao-Hsien Chu, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 24.95233, lon: 121.20193, locations facility: Bristol Royal Infirmary, status: NOT_YET_RECRUITING, city: Bristol, state: Bristol, City Of, zip: BS2 8HW, country: United Kingdom, contacts name: Paul Downie, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 51.45523, lon: -2.59665, locations facility: Torbay Hospital, status: NOT_YET_RECRUITING, city: Torquay, state: Devon, zip: TQ2 7AA, country: United Kingdom, contacts name: Jamie Smith, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 50.46198, lon: -3.5252, locations facility: Royal Free London NHS Foundation Trust, status: NOT_YET_RECRUITING, city: London, state: England, zip: NW32QG, country: United Kingdom, contacts name: Devaki Nair, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 51.50853, lon: -0.12574, locations facility: Lister Hospital, status: RECRUITING, city: Stevenage, state: Hertfordshire, zip: SG1 4AB, country: United Kingdom, contacts name: Mary Lynch, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 51.90224, lon: -0.20256, locations facility: Hull and East Yorkshire Hospitals NHS Trust, status: RECRUITING, city: Hull, state: Kingston Upon Hull, zip: HU3 2JZ, country: United Kingdom, contacts name: Deepa Narayanan, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 53.7446, lon: -0.33525, locations facility: Panthera Biopartners - Manchester, status: RECRUITING, city: Rochdale, state: Manchester, zip: OL11 4AU, country: United Kingdom, contacts name: Krishnakumar Radhakrishnan, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 53.61766, lon: -2.1552, locations facility: Salford Royal Hospital, status: RECRUITING, city: Salford, state: Manchester, zip: M6 8HD, country: United Kingdom, contacts name: John Gibson, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 53.48771, lon: -2.29042, locations facility: Panthera Biopartners - Glasgow, status: RECRUITING, city: Glasgow, state: Scotland, zip: G51 4TY, country: United Kingdom, contacts name: Raghavendra Madimchetty, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 55.86515, lon: -4.25763, locations facility: Sunderland Royal Hospital, status: RECRUITING, city: Tyne And Wear, zip: SR4 7TP, country: United Kingdom, contacts name: Peter Carey, role: PRINCIPAL_INVESTIGATOR, locations facility: Sandwell General Hospital, status: RECRUITING, city: West Bromwich, zip: B71 4HJ, country: United Kingdom, contacts name: Inessa Tracey, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 52.51868, lon: -1.9945, hasResults: False |
protocolSection identificationModule nctId: NCT06292000, orgStudyIdInfo id: 23-1721, briefTitle: Examining the Effects of Morning and Evening Exercise on Glucose Regulation in Adults With Prediabetes, acronym: TExIS, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-02-01, primaryCompletionDateStruct date: 2026-06, completionDateStruct date: 2026-06, studyFirstPostDateStruct date: 2024-03-04, lastUpdatePostDateStruct date: 2024-03-29, sponsorCollaboratorsModule leadSponsor name: University of Colorado, Denver, class: OTHER, descriptionModule briefSummary: Purpose of the Study: This study is to learn more about how exercising at different times of the day (morning versus evening) affects metabolism of glucose in the body, sleep, activity outside of exercise, and other factors.Procedures:* 2 screening visits to make sure you are eligible to be in the study. This will include a fasting blood draw and heart tracing (EKG).* If you are eligible, you will complete both exercise conditions in a random order. All participants in the study will complete the following separated by 3-4 weeks: * Baseline condition of NO exercise * Morning exercise for 3 days in a row * Evening exercise for 3 days in a row* You will be provided with an example diet to follow for the days you are completing the baseline and exercise conditions (three days total for each condition). This diet will be a "traditional" diet with a controlled amount of carbohydrates, protein, and fat per day. The investigators will provide you with examples of meals to eat during this time.* You will be asked questions and complete questionnaires about your health history, sleeping and awakening habits, and sleepiness levels.* You will undergo one x-ray scan to measure your level of body fat.* You will be asked to wear an activity monitor and sleep monitor for 6 days in a row three times during this study.* You will be asked to wear a continuous glucose monitor (CGM) for 6 days in a row three times during this study.* You will be asked to measure your saliva melatonin levels three times in the study. This will be done once per hour for 5 hours (a total of 6 saliva samples).* You will be asked to complete a procedure called a "hyperinsulinemic-euglycemic clamp" where you will have an IV placed and insulin and glucose infused with frequent lab and finger stick blood sugars monitored closely. This will be done 3 times during the study., conditionsModule conditions: PreDiabetes, conditions: Obesity, conditions: Inactivity/Low Levels of Exercise, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: CROSSOVER, primaryPurpose: TREATMENT, maskingInfo masking: SINGLE, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 25, type: ESTIMATED, armsInterventionsModule interventions name: AM Exercise, interventions name: PM Exercise, outcomesModule primaryOutcomes measure: Peripheral insulin sensitivity, secondaryOutcomes measure: Free Living Glucose, secondaryOutcomes measure: Melatonin offset, secondaryOutcomes measure: AM Cortisol, secondaryOutcomes measure: Physical activity and sedentary behavior, secondaryOutcomes measure: Sleep outcomes, eligibilityModule sex: ALL, minimumAge: 20 Years, maximumAge: 40 Years, stdAges: ADULT, contactsLocationsModule locations facility: University of Colorado, status: RECRUITING, city: Aurora, state: Colorado, zip: 80045, country: United States, contacts name: Rebecca Rosenberg, DO, role: CONTACT, phone: 503-442-0762, email: [email protected], contacts name: Rebecca Rosenberg, DO, role: PRINCIPAL_INVESTIGATOR, contacts name: Seth Creasy, PhD, role: SUB_INVESTIGATOR, contacts name: Victoria Catenacci, MD, role: SUB_INVESTIGATOR, geoPoint lat: 39.72943, lon: -104.83192, hasResults: False |
protocolSection identificationModule nctId: NCT06291987, orgStudyIdInfo id: IRB23-1681, briefTitle: Ivosidenib and Ruxolitinib in Patients With Advanced Myeloproliferative Neoplasms (MPNs) That Have an IDH1 Gene Mutation, acronym: MPN, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-05-20, primaryCompletionDateStruct date: 2026-05, completionDateStruct date: 2026-05, studyFirstPostDateStruct date: 2024-03-04, lastUpdatePostDateStruct date: 2024-04-26, sponsorCollaboratorsModule leadSponsor name: University of Chicago, class: OTHER, descriptionModule briefSummary: The purpose of this research is to gather information on the safety and effectiveness determining maximum tolerated dose (MTD) of ruxolitinib in combination with ivosidenib in IDH1-mutated advanced-phase Ph-negative MPNs while evaluate the efficacy of ruxolitinib in combination with ivosidenib in IDH1-mutated advanced-phase Ph-negative MPNs., conditionsModule conditions: Myeloproliferative Neoplasms, designModule studyType: INTERVENTIONAL, phases: PHASE1, designInfo allocation: NON_RANDOMIZED, interventionModel: SEQUENTIAL, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 18, type: ESTIMATED, armsInterventionsModule interventions name: Ivosidenib, interventions name: Ruxolitinib, outcomesModule primaryOutcomes measure: Maximum tolerated dose, secondaryOutcomes measure: Overall Survival (OS), secondaryOutcomes measure: Overall Response Rate (ORR), secondaryOutcomes measure: Time to Response (TTR), secondaryOutcomes measure: Duration of response (DOR), secondaryOutcomes measure: Progression free survival (PFS), eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: University of Chicago Medicine Comprehensive Cancer Center, city: Chicago, state: Illinois, zip: 60637, country: United States, contacts name: Clinical Trials Intake, role: CONTACT, phone: 855-702-8222, email: [email protected], contacts name: Anand Patel, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 41.85003, lon: -87.65005, hasResults: False |
protocolSection identificationModule nctId: NCT06291974, orgStudyIdInfo id: delta2024, briefTitle: Ankle Foot Orthosis on Muscle Activity in Cerebral Palsy, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-03-15, primaryCompletionDateStruct date: 2024-10-15, completionDateStruct date: 2024-11-30, studyFirstPostDateStruct date: 2024-03-04, lastUpdatePostDateStruct date: 2024-03-07, sponsorCollaboratorsModule leadSponsor name: Delta University for Science and Technology, class: OTHER, descriptionModule briefSummary: To compare the effect of solid ankle foot orthosis and ground reaction foot orthosis on the muscle activity in children with spastic diplegic cerebral palsy (Gross Motor Functional Classification Scale III)., conditionsModule conditions: Cerebral Palsy Spastic Diplegia, designModule studyType: OBSERVATIONAL, designInfo observationalModel: OTHER, timePerspective: PROSPECTIVE, enrollmentInfo count: 30, type: ESTIMATED, armsInterventionsModule interventions name: electromyography, outcomesModule primaryOutcomes measure: muscle activity by Electromyography device, eligibilityModule sex: ALL, minimumAge: 6 Years, maximumAge: 12 Years, stdAges: CHILD, hasResults: False |
protocolSection identificationModule nctId: NCT06291961, orgStudyIdInfo id: CS-101-01, briefTitle: A Safety and Efficacy Study Evaluating CS-101 in Subjects With β-Thalassemia Major, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-03, primaryCompletionDateStruct date: 2025-05, completionDateStruct date: 2025-07, studyFirstPostDateStruct date: 2024-03-04, lastUpdatePostDateStruct date: 2024-03-06, sponsorCollaboratorsModule leadSponsor name: CorrectSequence Therapeutics Co., Ltd, class: INDUSTRY, descriptionModule briefSummary: The goal of this open label, single-arm clinical study is to learn about the safety and efficacy of CS-101 in treating patients with β-thalassemia major anemia., conditionsModule conditions: Beta-Thalassemia Major, designModule studyType: INTERVENTIONAL, phases: PHASE1, designInfo allocation: NA, interventionModel: SINGLE_GROUP, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 8, type: ESTIMATED, armsInterventionsModule interventions name: CS-101 injection, outcomesModule primaryOutcomes measure: AEs(Adverse Events) and SAEs(Serious Adverse Events) after CS-101 infusion, primaryOutcomes measure: Overall survival rate, primaryOutcomes measure: Proportion of subjects with engraftment, primaryOutcomes measure: Time to neutrophil engraftment, primaryOutcomes measure: Time to platelet engraftment, primaryOutcomes measure: Incidence of transplant-related mortality, primaryOutcomes measure: Change in fetal hemoglobin(HbF) concentration over time, primaryOutcomes measure: Change in total hemoglobin(Hb) concentration over time, secondaryOutcomes measure: Chimerism level in Peripheral blood and bone marrow, secondaryOutcomes measure: Proportion of subjects achieving transfusion independence for at least 6 consecutive months, secondaryOutcomes measure: Proportion of subjects achieving fetal hemoglobin(HbF) increase≥2.0 g/dL, secondaryOutcomes measure: Proportion of subjects achieving fetal hemoglobin(HbF) increase≥7.0 g/dL, eligibilityModule sex: ALL, minimumAge: 7 Years, maximumAge: 35 Years, stdAges: CHILD, stdAges: ADULT, contactsLocationsModule locations facility: The First Affiliated Hospital of Guangxi Medical University, city: Nanning, state: Guangxi, country: China, contacts name: Yongrong Lai, M.D., role: CONTACT, contacts name: Yongrong Lai, M.D., role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 22.81667, lon: 108.31667, locations facility: Children's Hospital of Fudan University, city: Shanghai, state: Shanghai, country: China, contacts name: Xiaowen Zhai, M.D., role: CONTACT, contacts name: Xiaowen Zhai, M.D., role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 31.22222, lon: 121.45806, locations facility: Ruijin Hospital Shanghai JiaoTong University School of Medicine, city: Shanghai, state: Shanghai, country: China, contacts name: Saijuan Chen, M.D., role: CONTACT, contacts name: Saijuan Chen, M.D., role: PRINCIPAL_INVESTIGATOR, contacts name: Weili Zhao, M.D., role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 31.22222, lon: 121.45806, hasResults: False |
protocolSection identificationModule nctId: NCT06291948, orgStudyIdInfo id: 0225, briefTitle: A Clinical Study With Adalimumab Biosimilar, statusModule overallStatus: COMPLETED, startDateStruct date: 2022-08-01, primaryCompletionDateStruct date: 2023-01-10, completionDateStruct date: 2023-10-20, studyFirstPostDateStruct date: 2024-03-04, lastUpdatePostDateStruct date: 2024-03-04, sponsorCollaboratorsModule leadSponsor name: Laboratorios Richmond S.A.C.I.F., class: INDUSTRY, collaborators name: FP Clinical Pharma S.R.L., collaborators name: Custom Biologics, descriptionModule briefSummary: The study aims to evaluate the pharmacokinetic profile, safety profile, and immunogenic potential of adalimumab of a new citrate-free formulation of adalimumab (Adalimumab Richmond) \[Test Product\] vs. Humira® AC Pen \[Reference Product\], conditionsModule conditions: Pharmacokinetics, conditions: Safety Issues, designModule studyType: INTERVENTIONAL, phases: PHASE1, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: A Randomized, Double Blind, Parallel groups, Phase 1 Clinical Study comparing the Pharmacokinetic, Safety and Immunogenicity of Adalimumab in Healthy Subjects., primaryPurpose: OTHER, maskingInfo masking: QUADRUPLE, maskingDescription: Study subjects, investigators, Sponsor, monitor, analytical center, and data analyst will be unaware of assigned treatments.Each product in its original primary packaging will be blinded and labeled with a fantasy name "Product A" or "Product B".The link between "Product A or B" with the Test Product or Reference Product will be kept in two separate copies in a sealed envelope. One copy will remain with the Sponsor and the other will be provided to the Principal Investigator. The envelope may only be opened in the event of a medical emergency. The investigator must follow the trial's randomization procedures, and must ensure that the code is broken only in accordance with the protocol. The investigator must promptly document and explain to the Sponsor should the identity of the investigational product be revealed (whether accidentally or due to a serious adverse event)., whoMasked: PARTICIPANT, whoMasked: CARE_PROVIDER, whoMasked: INVESTIGATOR, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 150, type: ACTUAL, armsInterventionsModule interventions name: Humira® (adalimumab) AC Pen [Reference Product], interventions name: Adalimumab Richmond [Test Product], outcomesModule primaryOutcomes measure: Peak Serum Concentration of adalimumab (Cmax), primaryOutcomes measure: Area Under the Serum Concentration-time Curve of adalimumab (ABC0-t), primaryOutcomes measure: Area Under the Serum Concentration- Time Curve ob adalimumab (ABC0-∞), secondaryOutcomes measure: Number of samples with positive Anti-adalimumab serum antibodies, otherOutcomes measure: Adverse Events, otherOutcomes measure: Number of positive Anti-adalimumab serum samples with neutralizing capacity, eligibilityModule sex: ALL, minimumAge: 21 Years, maximumAge: 55 Years, stdAges: ADULT, contactsLocationsModule locations facility: FP Clinical Pharma S.R.L., city: Buenos Aires, zip: C1425BAA, country: Argentina, geoPoint lat: -34.61315, lon: -58.37723, hasResults: False |
protocolSection identificationModule nctId: NCT06291935, orgStudyIdInfo id: VG901-2021 A, secondaryIdInfos id: EU CT: 2023-504383-42-00, type: OTHER, domain: EMA, briefTitle: Safety and Tolerability of Intravitreal Administration of VG901 in Patients With Retinitis Pigmentosa Due to Mutations in the CNGA1 Gene, statusModule overallStatus: RECRUITING, startDateStruct date: 2023-09-01, primaryCompletionDateStruct date: 2025-12, completionDateStruct date: 2025-12, studyFirstPostDateStruct date: 2024-03-04, lastUpdatePostDateStruct date: 2024-03-04, sponsorCollaboratorsModule leadSponsor name: ViGeneron GmbH, class: INDUSTRY, descriptionModule briefSummary: The goal of this phase 1 clinical trial is to learn about the safety and efficacy of a gene therapy, VG901, in patients with a rare disorder of the eye called Retinitis Pigmentosa. The main questions the study aims to answer are:* What is the best tolerated dose and are there any side effects, in particular any inflammatory reactions post drug administration?* Are there any early signs of efficacy on visual function?Participants will be administered a single intravitreal dose of VG901 into the most affected eye through a syringe and followed up for a year to monitor safety and efficacy. There will be two cohorts of participants in this study. Study Cohort 1 will receive the low dose and Study Cohort 2 will receive the high dose as specified in the Protocol., conditionsModule conditions: Retinitis Pigmentosa, designModule studyType: INTERVENTIONAL, phases: PHASE1, designInfo allocation: NA, interventionModel: SEQUENTIAL, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 6, type: ESTIMATED, armsInterventionsModule interventions name: VG901, outcomesModule primaryOutcomes measure: Adverse Events (AEs) and Serious Adverse Events (SAEs), secondaryOutcomes measure: Physical Examination, secondaryOutcomes measure: Pulse rate, secondaryOutcomes measure: Blood pressure, secondaryOutcomes measure: Body temperature, secondaryOutcomes measure: Respiratory rate, secondaryOutcomes measure: Slit lamp examination, secondaryOutcomes measure: Fundus biomicroscopy, secondaryOutcomes measure: Optical coherence tomography (OCT), secondaryOutcomes measure: Fundus autofluorescence, secondaryOutcomes measure: Tonometry, secondaryOutcomes measure: Adeno-associated virus (AAV) spread, secondaryOutcomes measure: Immunopathology, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Center for Ophthalmology, University of Tuebingen, status: RECRUITING, city: Tuebingen, zip: 72076, country: Germany, contacts name: Andrea Rindtorff, role: CONTACT, geoPoint lat: 48.52266, lon: 9.05222, hasResults: False |
protocolSection identificationModule nctId: NCT06291922, orgStudyIdInfo id: 853181, secondaryIdInfos id: R01HL166621, type: NIH, link: https://reporter.nih.gov/quickSearch/R01HL166621, briefTitle: Home-Based Exercise Program Using Mobile Technology After Left Ventricular Assist Device Implantation, acronym: MOVE-LVAD II, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-05, primaryCompletionDateStruct date: 2028-06, completionDateStruct date: 2028-06, studyFirstPostDateStruct date: 2024-03-04, lastUpdatePostDateStruct date: 2024-04-16, sponsorCollaboratorsModule leadSponsor name: University of Pennsylvania, class: OTHER, collaborators name: National Heart, Lung, and Blood Institute (NHLBI), descriptionModule briefSummary: The goal of this clinical trial is to evaluate the effects of a home-based exercise program using mobile technology on physical activity and capacity, frailty and muscle mass, and quality of life in patients with a newly implanted HeartMate 3 left ventricular assist device (HM3 LVAD). Researchers will compare the effects of an exercise intervention vs. usual care on physical activity and capacity, frailty and muscle mass, and quality of life., conditionsModule conditions: Heart Failure, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 80, type: ESTIMATED, armsInterventionsModule interventions name: Exercise Intervention, interventions name: Usual Care, outcomesModule primaryOutcomes measure: Effects of exercise intervention on physical activity and capacity (step count), primaryOutcomes measure: Effects of exercise intervention on physical activity and capacity (distance), secondaryOutcomes measure: Effects of exercise intervention on frailty and muscle mass (frailty status), secondaryOutcomes measure: Effects of exercise intervention on frailty and muscle mass (muscle quantity), secondaryOutcomes measure: Effects of exercise intervention on quality of life, secondaryOutcomes measure: Cost-effectiveness of the exercise intervention vs. usual care, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False |
protocolSection identificationModule nctId: NCT06291909, orgStudyIdInfo id: 205989, briefTitle: Small Steps Towards Improving Activity and Sleep Habits to Decrease the Risk of Dementia, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-04-03, primaryCompletionDateStruct date: 2026-12, completionDateStruct date: 2027-01, studyFirstPostDateStruct date: 2024-03-04, lastUpdatePostDateStruct date: 2024-03-29, sponsorCollaboratorsModule leadSponsor name: University of South Australia, class: OTHER, collaborators name: Flinders University, descriptionModule briefSummary: This is a randomised controlled study aiming to evaluate the implementation of a website ('Small Steps') to support the modification of participants' time-use behaviour to reduce the risk factors for dementia. 'Small Steps' website provides the tools for this with a visual representation of the participant's current use of time and allowing manipulation to demonstrate how small lifestyle changes may improve and meet sleep and physical activity needs. Participants will be assisted to make changes to current behaviours with the aim to reduce the time they spend sitting (sedentary behaviour), increase physical activity, and improve sleep duration and quality.Participants (aged 65 or older) will be randomly allocated to one of two groups, the 'Extended Program' (intervention) group or the 'Condensed Program' (control) group.There are 3 phases (Introductory, Maintenance and Follow-Up; each 12-weeks long) to this program and in total the program is 36-weeks long. Participants will use a tailored website to help support them in making progressive changes over the first 12 weeks. They will then try to maintain these behaviour changes for as long as possible. There will be in-person health testing during each phase and information about sleep habits, sleep quality, and motivation will be assessed using online surveys. Physical activity levels and sleep duration will also be assessed., conditionsModule conditions: Dementia, conditions: Alzheimer Disease, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: PREVENTION, maskingInfo masking: SINGLE, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 88, type: ESTIMATED, armsInterventionsModule interventions name: Small Steps Program, interventions name: Comparator Program, outcomesModule primaryOutcomes measure: Number of participant logins onto the "Small Steps" website, primaryOutcomes measure: Number of participant check-ins on the "Small Steps" dashboard, primaryOutcomes measure: Number of participant behavioural change choices on the "Small Steps" website during the Introduction Phase. The greater number of choices indicates a greater engagement with the intervention and use of the website., primaryOutcomes measure: Time participants spent on the "Small Steps" website, primaryOutcomes measure: Duration of each participant behavioural change choice during the Introductory Phase, primaryOutcomes measure: Holden's Simplified System Usability Scale, primaryOutcomes measure: Health Care Climate Questionnaire, primaryOutcomes measure: Behavioural Automaticity Questionnaire, primaryOutcomes measure: (Behavioural Regulation in Exercise Questionnaire, primaryOutcomes measure: Self-efficacy and Intention Questionnaire, primaryOutcomes measure: Perceived Competence Scale, primaryOutcomes measure: Exit interview, primaryOutcomes measure: Daily activity, primaryOutcomes measure: Sleep quality, primaryOutcomes measure: Sleep Hygiene, primaryOutcomes measure: Sleep quantity, secondaryOutcomes measure: Addenbrooke's Cognitive Exam III, secondaryOutcomes measure: Trail Making Test, secondaryOutcomes measure: Digit Span Test, eligibilityModule sex: ALL, minimumAge: 65 Years, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: University of South Australia, status: RECRUITING, city: Adelaide, state: South Australia, zip: 5001, country: Australia, contacts name: Catherine Yandell, PhD, role: CONTACT, phone: +61 8 83022109, email: [email protected], contacts name: Emma Waters, BSc(Hon), role: CONTACT, contacts name: Ashleigh Smith, PhD, role: PRINCIPAL_INVESTIGATOR, contacts name: Maddison Mellow, PhD, role: SUB_INVESTIGATOR, contacts name: Dorothea Dumuid, PhD, role: SUB_INVESTIGATOR, contacts name: Tyman Stanford, PhD, role: SUB_INVESTIGATOR, contacts name: Timothy Olds, PhD, role: SUB_INVESTIGATOR, contacts name: Hannah Keage, PhD, role: SUB_INVESTIGATOR, contacts name: Ross Smith, PhD, role: SUB_INVESTIGATOR, contacts name: Alison Coates, PhD, role: SUB_INVESTIGATOR, contacts name: Michelle Rogers, PhD, role: SUB_INVESTIGATOR, contacts name: Catherine Yandell, PhD, role: SUB_INVESTIGATOR, contacts name: Emma Waters, BSc(Hon), role: SUB_INVESTIGATOR, contacts name: Kate Laver, PhD, role: SUB_INVESTIGATOR, contacts name: Alexander Wade, PhD, role: SUB_INVESTIGATOR, geoPoint lat: -34.92866, lon: 138.59863, hasResults: False |
protocolSection identificationModule nctId: NCT06291896, orgStudyIdInfo id: UBT 2023-01, briefTitle: A Clinical Investigation to Evaluate Microwave Imaging Via MammoWave® in a Population-based Screening Program for Early Breast Cancer Detection, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-03-15, primaryCompletionDateStruct date: 2026-02-15, completionDateStruct date: 2026-12-15, studyFirstPostDateStruct date: 2024-03-04, lastUpdatePostDateStruct date: 2024-03-08, sponsorCollaboratorsModule leadSponsor name: Umbria Bioengineering Technologies, class: INDUSTRY, collaborators name: Toscana Life Sciences Sviluppo s.r.l., collaborators name: London South Bank University, collaborators name: ELAROS 24/7 Limited (UK), collaborators name: Servicio De Salud De Castilla La Mancha (Spain), collaborators name: IMT School for Advanced Studies Lucca, collaborators name: EVITA - Cancro Hereditário (Portugal), descriptionModule briefSummary: This is an open, multicentric, interventional, prospective, non-randomized clinical investigation. The first aim of the study is to confirm that MammoWave reaches sensitivity\>75% and specificity\>90% in breast cancer (BC) detection on 10.000 volunteers undergoing regular screening programs., conditionsModule conditions: Women's Health: Neoplasm of Breast, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NA, interventionModel: SINGLE_GROUP, interventionModelDescription: Clinical Investigation with class IIa medical device, primaryPurpose: SCREENING, maskingInfo masking: NONE, enrollmentInfo count: 10000, type: ESTIMATED, armsInterventionsModule interventions name: MammoWave, outcomesModule primaryOutcomes measure: MammoWave® sensitivity, primaryOutcomes measure: MammoWave® specificity, secondaryOutcomes measure: Detection rates by type of lesion, secondaryOutcomes measure: Recall rate, secondaryOutcomes measure: Positive-predictive value, secondaryOutcomes measure: Program screening rate, secondaryOutcomes measure: BC detection rates of each by histological type and size of the BC and BI-RADS classification, also by breast density, secondaryOutcomes measure: MammoWave® sensitivity and specificity after retrospective AI adjustment using the data at the end of the study, secondaryOutcomes measure: Agreement between different evaluator (i.e. local versus central), secondaryOutcomes measure: Volunteers' satisfaction questionnaire, eligibilityModule sex: FEMALE, minimumAge: 45 Years, maximumAge: 74 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Ospedale San Giovanni Battista - USL Umbria 2, status: NOT_YET_RECRUITING, city: Foligno, state: Perugia, zip: 06034, country: Italy, contacts name: Riccardo Loretoni, role: CONTACT, email: [email protected], contacts name: Riccardo Loretoni, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 42.95488, lon: 12.70268, locations facility: IRCCS Policlinico San Martino, status: RECRUITING, city: Genova, zip: 16132, country: Italy, contacts name: Massimo Calabrese, role: CONTACT, email: [email protected], contacts name: Massimo Calabrese, role: PRINCIPAL_INVESTIGATOR, contacts name: Alberto Stefano Tagliafico, role: SUB_INVESTIGATOR, geoPoint lat: 44.40478, lon: 8.94438, locations facility: Pomeranian Medical University Hospital, status: NOT_YET_RECRUITING, city: Szczecin, country: Poland, contacts name: Jan Lubinsky, role: CONTACT, email: [email protected], contacts name: Jan Lubinsky, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 53.42894, lon: 14.55302, locations facility: Champalimaud Foundation, status: NOT_YET_RECRUITING, city: Lisboa, country: Portugal, contacts name: Filipa Lourenço Cardoso, role: CONTACT, email: [email protected], contacts name: Celeste Alves, role: PRINCIPAL_INVESTIGATOR, contacts name: Maria Antónia Vasconcelos, role: SUB_INVESTIGATOR, geoPoint lat: 38.71667, lon: -9.13333, locations facility: Clínica Dr. Passos Ângelo in Lisbon, status: NOT_YET_RECRUITING, city: Lisboa, country: Portugal, contacts name: Ângelo Passos, role: CONTACT, email: [email protected], contacts name: Ângelo Passos, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 38.71667, lon: -9.13333, locations facility: Hospital Universitario Reina Sofía- Córdoba, status: NOT_YET_RECRUITING, city: Córdoba, country: Spain, contacts name: Marina Álvarez Benito, role: CONTACT, email: [email protected], contacts name: Marina Álvarez Benito, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 37.89155, lon: -4.77275, locations facility: Hospital General Universitario Morales Meseguer, status: NOT_YET_RECRUITING, city: Murcia, country: Spain, contacts name: María Martínez Gálvez, role: CONTACT, email: [email protected], contacts name: María Martínez Gálvez, role: PRINCIPAL_INVESTIGATOR, contacts name: Este Correo, role: SUB_INVESTIGATOR, geoPoint lat: 37.98704, lon: -1.13004, locations facility: Complejo Hospitalario Universitario de Toledo, status: NOT_YET_RECRUITING, city: Toledo, country: Spain, contacts name: Daniel Alvarez Sánchez-Bayuela, role: CONTACT, email: [email protected], contacts name: Cristina Romero Castellano, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 39.8581, lon: -4.02263, locations facility: Diagnostic and Interventional Radiology, University Hospital Zurich, status: NOT_YET_RECRUITING, city: Zürich, country: Switzerland, contacts name: Thomas Frauenfelder, role: CONTACT, email: [email protected], contacts name: Thomas Frauenfelder, role: PRINCIPAL_INVESTIGATOR, contacts name: Jann Wieler, role: SUB_INVESTIGATOR, geoPoint lat: 47.36667, lon: 8.54999, hasResults: False |
protocolSection identificationModule nctId: NCT06291883, orgStudyIdInfo id: CHUH112-REC2-008, briefTitle: Evaluation of KGR Prescriptions in Suppressing COVID-19 Infection., statusModule overallStatus: COMPLETED, startDateStruct date: 2023-02-09, primaryCompletionDateStruct date: 2023-04-18, completionDateStruct date: 2024-02-08, studyFirstPostDateStruct date: 2024-03-04, lastUpdatePostDateStruct date: 2024-03-06, sponsorCollaboratorsModule leadSponsor name: Sheng-Teng Huang, class: OTHER, descriptionModule briefSummary: These studies offer valuable insights into the potential development of KGR as a novel herbal-based preventive and therapeutic strategy against COVID-19., conditionsModule conditions: Coronavirus Disease 2019, conditions: Severe Acute Respiratory Syndrome Coronavirus 2 Infection, designModule studyType: INTERVENTIONAL, phases: PHASE1, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: BASIC_SCIENCE, maskingInfo masking: SINGLE, whoMasked: PARTICIPANT, enrollmentInfo count: 26, type: ACTUAL, armsInterventionsModule interventions name: Kang Guan Recipe (Treat), interventions name: Kang Guan Recipe (Placebo), outcomesModule primaryOutcomes measure: Serum Infection rate of pseudocells, eligibilityModule sex: ALL, minimumAge: 20 Years, maximumAge: 60 Years, stdAges: ADULT, contactsLocationsModule locations facility: China Medical University Hospital, city: Taichung, state: North District, zip: 404, country: Taiwan, geoPoint lat: 24.1469, lon: 120.6839, hasResults: False |
protocolSection identificationModule nctId: NCT06291870, orgStudyIdInfo id: F4396-P, secondaryIdInfos id: IRB-22-01-4294, type: OTHER, domain: John D. Dingell VA Medical Center, briefTitle: Predictors of Post-COVID Clinical and Cognitive Consequences, acronym: SCLC, statusModule overallStatus: RECRUITING, startDateStruct date: 2023-01-19, primaryCompletionDateStruct date: 2025-07-30, completionDateStruct date: 2025-12-30, studyFirstPostDateStruct date: 2024-03-04, lastUpdatePostDateStruct date: 2024-04-01, sponsorCollaboratorsModule leadSponsor name: VA Office of Research and Development, class: FED, collaborators name: John D. Dingell VA Medical Center, descriptionModule briefSummary: The CDC describes Post-acute sequelae of SARS-COV-2 infection (PASC) for the wide range of physical and mental health consequences experienced by some patients. These sequelae may be present four or more weeks after SARS-COV-2 infection, including patients who had initial mild or asymptomatic acute infection. However, there is complete absence of data whether chronic sleep changes due to COVID-19 infection may influence these physical and mental health consequences. While fatigue is one of the common post-COVID conditions, there are no systematic examinations of sleep disturbances in COVID-19 survivors. This will be a pilot observational retrospective and prospective cohort study, to systematically assess if sleep disturbances and severity of sleep apnea comprise a modifiable facet of PASC as well as the short-term and longer-term effects of COVID-19 infection itself on sleep, cognitive function, exercise capacity and lung function., conditionsModule conditions: Post Acute Sequelae of SARS CoV 2 Infection, conditions: Obstructive Sleep Apnea, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 120, type: ESTIMATED, armsInterventionsModule, outcomesModule primaryOutcomes measure: Neurocognitive function Trails A and Trails B, primaryOutcomes measure: Neurocognitive function PASAT, primaryOutcomes measure: Neurocognitive function Stroop color-word interference, primaryOutcomes measure: Neurocognitive function DIGIT, primaryOutcomes measure: Neurocognitive function WASI, primaryOutcomes measure: Neurocognitive function WMS, primaryOutcomes measure: Neurocognitive function PVT, primaryOutcomes measure: Neurocognitive function HVLT-R, primaryOutcomes measure: Sleepiness ESS, primaryOutcomes measure: Sleep quality PSQI, primaryOutcomes measure: Quality of life SF-36v2, primaryOutcomes measure: Quality of life FOSQ, primaryOutcomes measure: Quality of life SGRQ, primaryOutcomes measure: Fatigue Severity, primaryOutcomes measure: PROMISE Sleep Disturbance, primaryOutcomes measure: Horne and Osteberg Morningness/Eveningness Questionnaire, primaryOutcomes measure: Mini Mental State Examination (MMSE), primaryOutcomes measure: Borg Scale, primaryOutcomes measure: Dyspnea: Six-minute walk test (6MWT) distance, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: John D. Dingell VA Medical Center, Detroit, MI, status: RECRUITING, city: Detroit, state: Michigan, zip: 48201-1916, country: United States, contacts name: Ruchi Rastogi, MS, role: CONTACT, phone: 313-576-4464, email: [email protected], contacts name: Susmita Chowdhuri, MD, MS, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 42.33143, lon: -83.04575, hasResults: False |
protocolSection identificationModule nctId: NCT06291857, orgStudyIdInfo id: CIC-E-301, briefTitle: A Study to Evaluate the Safety and Immunogenicity of COVID-19 Vaccine and Influenza Combination Vaccine, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-08-30, primaryCompletionDateStruct date: 2025-03-15, completionDateStruct date: 2025-04-09, studyFirstPostDateStruct date: 2024-03-04, lastUpdatePostDateStruct date: 2024-03-20, sponsorCollaboratorsModule leadSponsor name: Novavax, class: INDUSTRY, descriptionModule briefSummary: The goal of this Phase 3 study is to compare the effectiveness, safety, and side effects of the CIC vaccine with approved flu vaccines and the Novavax COVID-19 Vaccine with adjuvant., conditionsModule conditions: COVID-19, designModule studyType: INTERVENTIONAL, phases: PHASE2, phases: PHASE3, designInfo allocation: RANDOMIZED, interventionModel: CROSSOVER, primaryPurpose: PREVENTION, maskingInfo masking: SINGLE, whoMasked: PARTICIPANT, enrollmentInfo count: 4000, type: ESTIMATED, armsInterventionsModule interventions name: CIC Vaccine Co-formulated tNIV2, SARSCoV-2 rS and Matrix-M Adjuvant, interventions name: Novavax COVID-19 Vaccine, interventions name: Comparator Influenza Vaccine - Fluarix, interventions name: Comparator Influenza Vaccine -Fluarix High Dose, interventions name: Placebo 0.9% sodium chloride for injection, outcomesModule primaryOutcomes measure: Safety- Solicited AEs over 7 days post-vaccination, For both local injection site symptoms/signs and systemic symptoms/signs, primaryOutcomes measure: Safety-Unsolicited AEs over 21 days post-vaccination and medically attended adverse events (MAAEs)., primaryOutcomes measure: Safety-Treatment-related MAAEs, serious adverse events (SAEs), and adverse events of special interest (AESIs) (including potential immune-mediated medical conditions [PIMMCs] and myocarditis and/or pericarditis) over 6 months, secondaryOutcomes measure: Immunogenicity- HAI antibody titers specific for the HA receptor binding domains of vaccine homologous A and B influenza strains Expressed as GMT, secondaryOutcomes measure: Immunogenicity- HAI antibody titers specific for the HA receptor binding domains of vaccine homologous A and B influenza strains Expressed as GMFR, secondaryOutcomes measure: Immunogenicity- HAI antibody titers specific for the HA receptor binding domains of vaccine homologous A and B influenza strains Expressed as SCR, secondaryOutcomes measure: Immunogenicity- HAI antibody titers specific for the HA receptor binding domains of vaccine homologous A and B influenza strains Expressed as GMTR, secondaryOutcomes measure: Influenza NAb responses: neutralizing antibody titers specific to vaccine homologous wild-type A and B influenza strains, is expressed as GMT, secondaryOutcomes measure: Influenza NAb responses: neutralizing antibody titers specific to vaccine homologous wild-type A and B influenza strains, is expressed as GMFR, secondaryOutcomes measure: Influenza NAb responses: neutralizing antibody titers specific to vaccine homologous wild-type A and B influenza strains, is expressed as SCR, secondaryOutcomes measure: Influenza NAb responses: neutralizing antibody titers specific to vaccine homologous wild-type A and B influenza strains, is expressed as GMTR, secondaryOutcomes measure: SARS-CoV-2 NAb responses: neutralizing antibody titers specific to the homologous SARS-CoV-2 strain Expressed as GMT, secondaryOutcomes measure: SARS-CoV-2 NAb responses: neutralizing antibody titers specific to the homologous SARS-CoV-2 strain Expressed as GMFR, secondaryOutcomes measure: SARS-CoV-2 NAb responses: neutralizing antibody titers specific to the homologous SARS-CoV-2 strain Expressed as SCR, secondaryOutcomes measure: SARS-CoV-2 NAb responses: neutralizing antibody titers specific to the homologous SARS-CoV-2 strain Expressed as GMTR, eligibilityModule sex: ALL, minimumAge: 50 Years, maximumAge: 75 Years, stdAges: ADULT, stdAges: OLDER_ADULT, hasResults: False |
protocolSection identificationModule nctId: NCT06291844, orgStudyIdInfo id: Cohort-Mata-2023-1, briefTitle: Ocular Trauma and COVID-19 in Indonesia, statusModule overallStatus: COMPLETED, startDateStruct date: 2021-01-01, primaryCompletionDateStruct date: 2022-03-31, completionDateStruct date: 2023-06-01, studyFirstPostDateStruct date: 2024-03-04, lastUpdatePostDateStruct date: 2024-03-04, sponsorCollaboratorsModule leadSponsor name: Prof. R. D. Kandou General Hospital, class: OTHER, descriptionModule briefSummary: Ocular injuries, a significant contributor to avoidable blindness globally, impact approximately 55 million individuals each year. Prompt initial treatment is vital for improving vision, yet the scarcity of skilled eye specialists often results in overcrowding at advanced medical centers. Moreover, the COVID-19 outbreak has introduced distinct factors into the management of ocular trauma. This research investigated the epidemiology of ocular injuries during the pandemic and offered observations on the distinctive hurdles and trends encountered., conditionsModule conditions: Ophthalmological Disorder, conditions: Ocular Injury, conditions: COVID-19, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 13, type: ACTUAL, outcomesModule primaryOutcomes measure: Ocular Trauma, eligibilityModule sex: ALL, stdAges: CHILD, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Department of Ophthalmology, Prof. R. D. Kandou General Hospital - Faculty of Medicine, Sam Ratulangi University, city: Manado, state: North Sulawesi, country: Indonesia, geoPoint lat: 1.48218, lon: 124.84892, hasResults: False |
protocolSection identificationModule nctId: NCT06291831, orgStudyIdInfo id: C4671050, briefTitle: A Study to Learn About the Use of Paxlovid in Patients With COVID-19 in the Kingdom of Bahrain., statusModule overallStatus: ACTIVE_NOT_RECRUITING, startDateStruct date: 2024-03-13, primaryCompletionDateStruct date: 2024-05-13, completionDateStruct date: 2024-05-13, studyFirstPostDateStruct date: 2024-03-04, lastUpdatePostDateStruct date: 2024-04-09, sponsorCollaboratorsModule leadSponsor name: Pfizer, class: INDUSTRY, descriptionModule briefSummary: The purpose of this study is to collect information on the:* general information of a group of people such as their age, sex* clinical information of the patients such as any other illness before having COVID 19.* the number of COVID-19 patients who meet and follow the most up to date World Health Organization (WHO) recommendations for medication to treat COVID-19 (such as version 14, published 10Nov2023) compared to Kingdom of Bahrain national recommendations* adult COVID-19 patients' health care resource use and outcomes within the 28-day period In adult patients with COVID-19 who have been prescribed nirmatrelvir and ritonavir treatment.This study will be conducted in the Kingdom of Bahrain. The study will capture information of the adult COVID-19 outpatients and inpatients who have been prescribed nirmatrelvir, ritonavir treatment and those not treated with nirmatrelvir, ritonavir.This study will have about 3000 patients treated with Paxlovid™ therapy and 1000 were not. The study will involve collection of patient information from medical records. The information collected can be either from papers or from computers.The study will include patient information of those who:* had COVID-19 infection during the study period from 16 February 2022 to 30 November 2022.* are 18 years of age or older. This study will help to inform decision-making on use of Paxlovid at the national level., conditionsModule conditions: COVID-19, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: RETROSPECTIVE, enrollmentInfo count: 3000, type: ESTIMATED, armsInterventionsModule interventions name: nirmatrelvir, ritonavir, interventions name: Controls, outcomesModule primaryOutcomes measure: Demographic characteristic of COVID-19 patients who have been Prescribed nirmatrelvir, ritonavir treatment and those not treated COVID antiviral: Age, primaryOutcomes measure: Demographic characteristic of COVID-19 patients who have been Prescribed nirmatrelvir, ritonavir treatment and those not treated COVID antiviral: Gender, primaryOutcomes measure: Demographic characteristic of COVID-19 patients who have been Prescribed nirmatrelvir, ritonavir treatment and those not treated COVID antiviral: Ethnicity, primaryOutcomes measure: Demographic characteristic of COVID-19 patients who have been Prescribed nirmatrelvir, ritonavir treatment and those not treated COVID antiviral: Education, primaryOutcomes measure: Demographic characteristic of COVID-19 patients who have been Prescribed nirmatrelvir, ritonavir treatment and those not treated COVID antiviral: Employment status, primaryOutcomes measure: Clinical characteristic of COVID-19 patients who have been Prescribed nirmatrelvir, ritonavir treatment and those not treated COVID antiviral: Height, primaryOutcomes measure: Clinical characteristic of COVID-19 patients who have been Prescribed nirmatrelvir, ritonavir treatment and those not treated COVID antiviral: Weight, primaryOutcomes measure: Clinical characteristic of COVID-19 patients who have been Prescribed nirmatrelvir, ritonavir treatment and those not treated COVID antiviral: Body Mass Index (BMI), primaryOutcomes measure: Clinical characteristic of COVID-19 patients who have been Prescribed nirmatrelvir, ritonavir treatment and those not treated COVID antiviral: Smoking status, primaryOutcomes measure: Clinical characteristic of COVID-19 patients who have been Prescribed nirmatrelvir, ritonavir treatment and those not treated COVID antiviral: Pre-existing Comorbidities, primaryOutcomes measure: Clinical characteristic of COVID-19 patients who have been Prescribed nirmatrelvir, ritonavir treatment and those not treated COVID antiviral: Concomitant medications for comorbidities at index date, primaryOutcomes measure: Clinical characteristic of COVID-19 patients who have been Prescribed nirmatrelvir, ritonavir treatment and those not treated COVID antiviral: Medications used to treat COVID-19, secondaryOutcomes measure: Assessment of all Participants HRU: Inpatient setting, secondaryOutcomes measure: Assessment of all Participants HRU, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Pfizer Gulf FZ, city: Busaiteen, country: Bahrain, hasResults: False |
protocolSection identificationModule nctId: NCT06291818, orgStudyIdInfo id: 2023-0917, briefTitle: Self-Adhering Magnetic Device to Treat Corneal Exposure, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-03-01, primaryCompletionDateStruct date: 2024-12-01, completionDateStruct date: 2025-04-01, studyFirstPostDateStruct date: 2024-03-04, lastUpdatePostDateStruct date: 2024-03-04, sponsorCollaboratorsModule leadSponsor name: University of Illinois at Chicago, class: OTHER, descriptionModule briefSummary: Paralytic lagophthalmos can be difficult to treat and manage. It has a host of causes and effects, one of which (for the latter) is exposure keratopathy. Untreated, this can lead to corneal ulceration, inflammation, and potentially blindness. Despite a variety of attempts at treating this complex condition, none have satisfactorily reduced complications ranging from ease of use to aesthetics. With improvement in magnetic technology, however, that may change. Barmettler et al (2014) have demonstrated preliminary success of externally affixed magnets in closing both model and patient eyelids. As such, we hypothesize that magnetic devices can be used to treat corneal exposure by controlling eyelid position., conditionsModule conditions: Paralytic Lagophthalmos, conditions: Corneal Exposure, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NA, interventionModel: SINGLE_GROUP, interventionModelDescription: temporary magnetic system for tarsorrhaphy (MST), primaryPurpose: OTHER, maskingInfo masking: NONE, enrollmentInfo count: 25, type: ESTIMATED, armsInterventionsModule interventions name: temporary magnetic system for tarsorrhaphy (MST), outcomesModule primaryOutcomes measure: Number of participants with success of a temporary magnetic system for tarsorrhaphy, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 80 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: University of Illinois - Specialty Care Building, city: Chicago, state: Illinois, zip: 60612, country: United States, contacts name: Pete Setabutr, MD, role: CONTACT, phone: 312-996-9120, email: [email protected], geoPoint lat: 41.85003, lon: -87.65005, hasResults: False |
protocolSection identificationModule nctId: NCT06291805, orgStudyIdInfo id: 1-10-72-189-23, briefTitle: Phenotyping and Characterization of wtATTR-CM (TRACE 1), statusModule overallStatus: RECRUITING, startDateStruct date: 2024-02-20, primaryCompletionDateStruct date: 2025-12, completionDateStruct date: 2025-12, studyFirstPostDateStruct date: 2024-03-04, lastUpdatePostDateStruct date: 2024-03-04, sponsorCollaboratorsModule leadSponsor name: Steen Hvitfeldt Poulsen, class: OTHER, collaborators name: Novo Nordisk A/S, descriptionModule briefSummary: Descriptive cross-sectional study on 100 consecutive ATTRwt-CM patients reflecting all NAC stages aiming primarily to investigate ATTRwt-CM patient's quality of life (QoL) measures and their relation to ATTRwt-CM severity. Secondarily aiming to investigate the possibility to measure misTTR and fragTTR in plasma and urine and to detect fragTTR in endomyocardial biopsies from ATTRwt-CM patients. To investigate whether misTTR and fragTTR levels are correlated with ATTRwt-CM severity., conditionsModule conditions: Transthyretin Amyloidosis, conditions: Transthyretin Amyloid Cardiomyopathy, conditions: Wild-Type Transthyretin-Related (ATTR)Amyloidosis, conditions: Quality of Life, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: CROSS_SECTIONAL, enrollmentInfo count: 120, type: ESTIMATED, armsInterventionsModule, outcomesModule primaryOutcomes measure: Investigation of cardiac amyloidosis severity in patients with Wild-type Transthyretin Amyloidosis Cardiomyopathy., primaryOutcomes measure: Investigation of the relations between cardiac amyloid severity and patient quality of life in patients with Wild-type Transthyretin Amyloidosis Cardiomyopathy., primaryOutcomes measure: Assessment of transthyretin and pathogenic fragments and relation to cardiac amyloid severity in patients with Wild-type Transthyretin Amyloidosis Cardiomyopathy, secondaryOutcomes measure: Validation of a new amyloid specific questionnaire (ATTR-QoL) in comparison with Kansas City Cardiomyopathy Questionnaire (KCCQ), eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Aarhus University Hospital, status: RECRUITING, city: Aarhus, state: Arrhus N, zip: 8200, country: Denmark, contacts name: Sie Kronborg Fensman, role: CONTACT, phone: +45 30 48 88 85, email: [email protected], geoPoint lat: 56.15674, lon: 10.21076, hasResults: False |
protocolSection identificationModule nctId: NCT06291792, orgStudyIdInfo id: FTR001, briefTitle: Otago Exercise Program Applied By Telerehabilitation, acronym: OEPABT, statusModule overallStatus: RECRUITING, startDateStruct date: 2023-11-01, primaryCompletionDateStruct date: 2024-03-01, completionDateStruct date: 2024-03-01, studyFirstPostDateStruct date: 2024-03-04, lastUpdatePostDateStruct date: 2024-03-04, sponsorCollaboratorsModule leadSponsor name: Sinop University, class: OTHER, descriptionModule briefSummary: The aim of this study is to examine the effects of Otago Exercise Program (OEP) on pain, walking speed, lower extremity muscle strength, fear of falling, anxiety, quality of life and balance with the telerehabilitation method in individuals with a history of falling, which is frequently seen in elderly individuals due to aging.45 people between the ages of 65 and 78 participated in the study. They were randomly divided into 3 groups as control, telerehabilitation otago exercise program (TOEG) and face-to-face otago exercise program (FOEG). 45 minutes of OEP was applied 3 times a week for 8 weeks. Pain, walking speed, lower extremity muscle strength, fear of falling, anxiety, quality of life, and balance were evaluated before the Otago Exercise Program, at the 4th week, at the 8th week, and 4 weeks after the end of the exercise program. Significance was evaluated at the p\<0.05 level in the study., conditionsModule conditions: Older People--Abuse of, conditions: Falling, conditions: Balance; Distorted, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: SINGLE, whoMasked: PARTICIPANT, enrollmentInfo count: 40, type: ESTIMATED, armsInterventionsModule interventions name: telerehabilitation otago exercise program, interventions name: face to face otago exercise program, outcomesModule primaryOutcomes measure: Numerical Pain Scale, primaryOutcomes measure: Walking Speed, primaryOutcomes measure: lower extremity muscle strength, primaryOutcomes measure: Fall effectiveness scale, primaryOutcomes measure: Beck anxiety scale, primaryOutcomes measure: Tinetti balance and walking test, primaryOutcomes measure: World Health Organization Quality of Life Scale:, eligibilityModule sex: ALL, minimumAge: 65 Years, maximumAge: 90 Years, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Bahçeşehir University research application center, status: RECRUITING, city: Istanbul, country: Turkey, contacts name: Sefa Haktan Hatık, PhD, role: CONTACT, email: [email protected], geoPoint lat: 41.01384, lon: 28.94966, hasResults: False |
protocolSection identificationModule nctId: NCT06291779, orgStudyIdInfo id: SNUBH-GS- HBP5, secondaryIdInfos id: E-2211-792-350 (local IRB), type: OTHER, domain: Seoul National University Bundang Hospital, briefTitle: Diagnosis of Pancreatic Cancer by Purine Metabolite (Hypoxanthine, Xanthine) in Urine, statusModule overallStatus: RECRUITING, startDateStruct date: 2022-11-30, primaryCompletionDateStruct date: 2024-02-26, completionDateStruct date: 2024-05-31, studyFirstPostDateStruct date: 2024-03-04, lastUpdatePostDateStruct date: 2024-03-04, sponsorCollaboratorsModule leadSponsor name: Ho-Seong Han, class: OTHER, collaborators name: Seoul National University Bundang Hospital, descriptionModule briefSummary: * This study aim to develope a diagnostic method of pancreatic cancer by using a reagent for analyzing purine metabolite (Hypoxanthine, Xanthine) in urine.* It is safe and cost effective compare to radiologic or blood test. It can be used for initial screening test for healty population., conditionsModule conditions: Pancreas Cancer, conditions: Diagnosis, designModule studyType: OBSERVATIONAL, designInfo observationalModel: CASE_CONTROL, timePerspective: PROSPECTIVE, enrollmentInfo count: 120, type: ESTIMATED, armsInterventionsModule interventions name: Purine metabolite (Hypoxanthine, Xanthine) in urine by CubeBio, outcomesModule primaryOutcomes measure: Urine, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 80 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Ho-Seong Han, status: RECRUITING, city: Seongnam, state: Gyeonggi-do, country: Korea, Republic of, geoPoint lat: 37.43861, lon: 127.13778, hasResults: False |
protocolSection identificationModule nctId: NCT06291766, orgStudyIdInfo id: 2022-05498-01, briefTitle: Gestational Diabetes After Gastric Bypass Surgery, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-01-01, primaryCompletionDateStruct date: 2028-12, completionDateStruct date: 2035-12, studyFirstPostDateStruct date: 2024-03-04, lastUpdatePostDateStruct date: 2024-03-04, sponsorCollaboratorsModule leadSponsor name: Region Skane, class: OTHER, descriptionModule briefSummary: The goal of this trial is to compare different means of glucose monitoring in women with gestational diabetes and a history of gastric bypass surgery.The main question it aims to answer is:How does continous glucose monitoring impact the treatment and affect pregnancy outcome in these women.Participants will be randomized to either continous glucose monitoring or regular capillary glucose measurements during the last trimester of their pregnancy. Researchers will compare the glucose measurement outcomes, the glucose lowering treatment given and pregnancy outcomes between groups., conditionsModule conditions: Diabetes, Gestational, conditions: Gastric Bypass Status for Obesity Complicating Pregnancy, Childbirth, or the Puerperium, conditions: Pregnancy in Diabetic, conditions: Blood Glucose Self Monitoring, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 120, type: ESTIMATED, armsInterventionsModule interventions name: FreeStyle Libre 2, continous glucose monitoring, outcomesModule primaryOutcomes measure: Adverse Pregnancy Outcome, secondaryOutcomes measure: Glucose values, secondaryOutcomes measure: Glucose values, secondaryOutcomes measure: Glucose values, secondaryOutcomes measure: Glucose values, secondaryOutcomes measure: Glucose values, secondaryOutcomes measure: Pharmacological treatment, secondaryOutcomes measure: Pharmacological treatment, secondaryOutcomes measure: Pharmacological treatment, secondaryOutcomes measure: Pharmacological treatment, secondaryOutcomes measure: Birthweight, secondaryOutcomes measure: Week of delivery, eligibilityModule sex: FEMALE, minimumAge: 18 Years, maximumAge: 50 Years, stdAges: ADULT, contactsLocationsModule locations facility: Region Skane, status: RECRUITING, city: Lund, zip: 221 85, country: Sweden, contacts name: Ulrika Moll, MD, PhD, role: CONTACT, geoPoint lat: 55.70584, lon: 13.19321, hasResults: False |
protocolSection identificationModule nctId: NCT06291753, orgStudyIdInfo id: SL-B2023-478-01, briefTitle: Characteristics and Tumor Staging Proposal for Primary Malignant Melanoma of the Esophagus, statusModule overallStatus: COMPLETED, startDateStruct date: 2023-09-22, primaryCompletionDateStruct date: 2024-02-18, completionDateStruct date: 2024-02-18, studyFirstPostDateStruct date: 2024-03-04, lastUpdatePostDateStruct date: 2024-03-04, sponsorCollaboratorsModule leadSponsor name: Sun Yat-sen University, class: OTHER, descriptionModule briefSummary: Background: Primary malignant melanoma of the esophagus (PMME) is a malignant tumor originating from esophageal melanocytes with a poor prognosis. No international clinical guidelines or tumor staging systems have been proposed for PMME. This study aimed to analyze the clinical characteristics and treatment outcomes of patients with PMME and propose a tumor staging system in PMME.Materials and Methods: The clinical characteristics of 25 patients with PMME at our cancer center were summarized, and 21 patients were enrolled in a pooled analysis with 162 cases (extracted from 74 eligible articles in PubMed) for further survival analysis and proposal of PMME tumor staging., conditionsModule conditions: Primary Malignant Melanoma of the Esophagus, designModule studyType: OBSERVATIONAL, designInfo observationalModel: CASE_CROSSOVER, timePerspective: RETROSPECTIVE, enrollmentInfo count: 25, type: ACTUAL, outcomesModule primaryOutcomes measure: Overall Survival(OS), primaryOutcomes measure: Disease-free survival (DFS), eligibilityModule sex: ALL, minimumAge: 23 Years, maximumAge: 72 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Qianwen Liu, city: Guangzhou, state: Guangdong, country: China, geoPoint lat: 23.11667, lon: 113.25, hasResults: False |
protocolSection identificationModule nctId: NCT06291740, orgStudyIdInfo id: MTU-EC-EM-2-008/67, secondaryIdInfos id: Faculty of Medicine, type: OTHER, domain: Thammasat University, Thailand, briefTitle: Continuous Versus Intermittent Nebulization Therapy in Acute Asthma Exacerbation at Emergency Department, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04, primaryCompletionDateStruct date: 2025-04, completionDateStruct date: 2025-05, studyFirstPostDateStruct date: 2024-03-04, lastUpdatePostDateStruct date: 2024-03-04, sponsorCollaboratorsModule leadSponsor name: Thammasat University, class: OTHER, descriptionModule briefSummary: The goal of this clinical is to compare treatment outcomes between continuous nebulization and intermittent therapy in the management of acute exacerbation of asthma in the emergency department(ED). Participants will random assign to either continuous or intermittent nebulization. In the continuous group, patients receive budesonide, fenoterol, ipratropium bromide, and normal saline continuously for an hour. In the intermittent group, the same medications are administer every 20 minutes for an hour. Measurements include symptom severity, respiratory rate, oxygen saturation, and pulmonary function tests. Primary endpoints are ED stay length, hospital admission, and ED revisit within 48 hours post-discharge. Adverse events are documented., conditionsModule conditions: Asthma Exacerbation, conditions: Emergency Department, conditions: Nebulization, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: randomized controlled trial (RCT), primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 40, type: ESTIMATED, armsInterventionsModule interventions name: continuous nebulization, interventions name: Intermittent nebulization, outcomesModule primaryOutcomes measure: Length of ED stay, secondaryOutcomes measure: pulmonary function test, otherOutcomes measure: Hospital admission, otherOutcomes measure: ED revisit within 48 hours, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False |
protocolSection identificationModule nctId: NCT06291727, orgStudyIdInfo id: Prisma Upstate, briefTitle: Mepivacaine vs Bupivacaine Spinal Anesthesia for TKA, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-02-16, primaryCompletionDateStruct date: 2025-07-01, completionDateStruct date: 2025-07-01, studyFirstPostDateStruct date: 2024-03-04, lastUpdatePostDateStruct date: 2024-03-04, sponsorCollaboratorsModule leadSponsor name: Prisma Health-Upstate, class: OTHER, descriptionModule briefSummary: This study is a prospective, double-blind prospective randomized controlled trial comparing mepivacaine and bupivacaine spinal anesthesia for same-day discharge readiness following a unilateral primary elective TKA procedure.Study data will be collected during the patient's hospital stay for their TKA procedure, and the primary outcome of same-day discharge readiness will be assessed the day of surgery. Patients will also be contacted at Day 3 post-op to assess for any complications, current level of pain, and pain medication utilization., conditionsModule conditions: Anesthesia, Spinal, conditions: Arthroplasty, Replacement, Knee, designModule studyType: INTERVENTIONAL, phases: PHASE4, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: Patients will be randomized 1:1 to one of two groups; one receiving Mepivacaine spinal anesthesia and the other receiving Bupivacaine spinal anesthesia for total knee arthroplasty (TKA)., primaryPurpose: TREATMENT, maskingInfo masking: DOUBLE, maskingDescription: Investigators and participants will not know which anesthetic agent they receive. Anesthesia providers will be aware in order to provide correct randomization., whoMasked: PARTICIPANT, whoMasked: INVESTIGATOR, enrollmentInfo count: 138, type: ESTIMATED, armsInterventionsModule interventions name: Mepivacaine, interventions name: Bupivacaine, outcomesModule primaryOutcomes measure: Same day discharge rate, secondaryOutcomes measure: Post-operative pain score as assessed by numeric rating scale (NRS), secondaryOutcomes measure: Urinary retention as assessed by time at which patient can voluntarily void bladder post-operatively, secondaryOutcomes measure: Return of sensory and motor function as assessed by ability of patient to plantar and dorsiflex lower extremity, secondaryOutcomes measure: Post-operative nausea and vomiting as assessed by clinical documentation of nausea and vomiting post-operatively, secondaryOutcomes measure: Pain Medications as evaluated by medical morphine equivalents, secondaryOutcomes measure: Patient satisfaction levels as assessed by a 5-item Likert response scale, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Prisma Health Patewood Hospital, status: RECRUITING, city: Greenville, state: South Carolina, zip: 29615, country: United States, contacts name: Kyle Adams, role: CONTACT, phone: 864-455-3449, email: [email protected], geoPoint lat: 34.85262, lon: -82.39401, hasResults: False |
protocolSection identificationModule nctId: NCT06291714, orgStudyIdInfo id: Clearsight, briefTitle: Non-invasive Measurement of the Hypotension Prediction Index for the Reduction of Intraoperative Hypotension, acronym: Clearsight, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04-01, primaryCompletionDateStruct date: 2025-03-31, completionDateStruct date: 2026-03-31, studyFirstPostDateStruct date: 2024-03-04, lastUpdatePostDateStruct date: 2024-03-15, sponsorCollaboratorsModule leadSponsor name: University of Giessen, class: OTHER, collaborators name: Edwards Lifesciences, descriptionModule briefSummary: In order to reduce the incidence of IOH, various goal-directed therapy (GDT) protocols have already been introduced with success regarding the reduction of postoperative AKI and MINS. However, these studies used an invasive hemodynamic monitoring which offered a continuous surveillance of the blood pressure. In contrast, standard non-invasive blood pressure monitoring results in a blind gap between two measurements (mostly three or five minutes). In order to address this limitation, different continuous non-invasive blood pressure monitoring devices have been introduced. The next evolutional step of non-invasive cardiac output monitoring was to prevent IOH before their onset by using the Hypotension Prediction Index (HPI). Based on the Edward ́s monitoring platform, HPI is a monitoring tool which aims to predict IOH (defined as MAP\<65 mmHg for at least one minute) up to 15 min before its onset. The underlying machine learning based algorithm uses analyses features from the pressure waveform and was first calculated from a large retrospective data set of surgical patients and subsequently validated in a prospective cohort. In this study HPI showed a sensitivity of 88% and specificity of 87% for predicting IOH 15 min before its onset. Since then, own and studies of other working groups confirmed the effective prevention of IOH by the use of HPI-based GDT. Until today the arterial waveform analysis was dependent on invasive arterial measurement but since Edwards Lifesciences already promoted the start of the HPI on the ClearSight platform a non-invasive measurement will soon be possible.Further, until now it has not yet been proven that the perioperative use of a continuous non-invasive blood pressure monitoring has a beneficial effect on the patient´s outcome.Study objectives The aim of the study is to investigate whether a hemodynamic protocol based on continuous non-invasive cardiac output monitoring (ClearSight system) compared to standard care can reduce the incidence of IOH, postoperative AKI, and MINS in patients undergoing major trauma and orthopedic surgery., conditionsModule conditions: Intraoperative Hypotension, conditions: Acute Kidney Injury, conditions: Myocardial Injury After Non-cardiac Surgery, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: Management of interventional group patients Prior to the surgery the rest cardiac index and contractility (dp/dt) must be quantified. For this purpose, the cardiac index will be measured in the preoperative night by applicating the HPI ClearSight system through a study team member. If the rest cardiac index is not available throughout the night because the patient´s sleep is altered by the measurements, the awake cardiac index will be quantified until the monitoring is stopped for the night sleep of the patient. This mean baseline measurements (CI and dp/dt) will then be the target cardiac index throughout the study algorithm (figure 1). In case no sleep measurement was achievable, the awake measurement will be accounted as baseline value. The perioperative study intervention period starts with the beginning of anesthesia and ends at the end of surgery. Intraoperative mean arterial pressure will be maintained at least at 65 mmHg and cardiac index and dp/dt will be individually, primaryPurpose: PREVENTION, maskingInfo masking: DOUBLE, maskingDescription: All patients are connected to the Clearsight device but the interface is masked in the control group., whoMasked: PARTICIPANT, whoMasked: CARE_PROVIDER, enrollmentInfo count: 150, type: ESTIMATED, armsInterventionsModule interventions name: GDT-based hemodynamic management based on Clearsight device, outcomesModule primaryOutcomes measure: Change of the frequency of intraoperative hypotension, primaryOutcomes measure: Change of the absolute duration of of intraoperative hypotension, primaryOutcomes measure: Change of the relative duration of intraoperative hypotension, secondaryOutcomes measure: AKI, secondaryOutcomes measure: MINS, eligibilityModule sex: ALL, minimumAge: 45 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False |
protocolSection identificationModule nctId: NCT06291701, orgStudyIdInfo id: ODUSBFFTR-ELIFAYGUNPOLAT-002, briefTitle: The Relationship Between Scapular Endurance, Core Endurance, and Functional Performance in Adolescent Tennis Players, statusModule overallStatus: ACTIVE_NOT_RECRUITING, startDateStruct date: 2024-03-15, primaryCompletionDateStruct date: 2024-04-01, completionDateStruct date: 2024-04-15, studyFirstPostDateStruct date: 2024-03-04, lastUpdatePostDateStruct date: 2024-04-04, sponsorCollaboratorsModule leadSponsor name: T.C. ORDU ÜNİVERSİTESİ, class: OTHER, descriptionModule briefSummary: This study aims to examine the relationship between scapular endurance, core endurance, and upper extremity performance in adolescent tennis players. The hypothesis of this study is that better scapular/core endurance in adolescent tennis players is associated with better upper extremity performance. Establishing this relationship will contribute to identifying the exercise training necessary to improve upper extremity performance in tennis players., conditionsModule conditions: Athletic Injuries, conditions: Sports Physical Therapy, designModule studyType: OBSERVATIONAL, designInfo observationalModel: CASE_ONLY, timePerspective: CROSS_SECTIONAL, enrollmentInfo count: 35, type: ESTIMATED, armsInterventionsModule interventions name: Assessment of scapular endurance, interventions name: Prone Bridge Test, interventions name: Side Bridge Test, interventions name: Closed Kinetic Chain Upper Extremity Stability Test, interventions name: Seated Medicine Ball Throw Test, outcomesModule primaryOutcomes measure: Prone Bridge Test, primaryOutcomes measure: Side Bridge Test, primaryOutcomes measure: Scapular Endurance Values, primaryOutcomes measure: Closed Kinetic Chain Upper Extremity Stability Test, primaryOutcomes measure: Seated Medicine Ball Throw Test, eligibilityModule sex: ALL, minimumAge: 11 Years, maximumAge: 18 Years, stdAges: CHILD, stdAges: ADULT, contactsLocationsModule locations facility: Ordu University, city: Ordu, zip: 52200, country: Turkey, geoPoint lat: 40.97782, lon: 37.89047, hasResults: False |
protocolSection identificationModule nctId: NCT06291688, orgStudyIdInfo id: 202312004RIND, briefTitle: Applying Mobile Healthcare Education to Improve Cutaneous Self-care Capability, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-01-26, primaryCompletionDateStruct date: 2025-12-31, completionDateStruct date: 2026-01-31, studyFirstPostDateStruct date: 2024-03-04, lastUpdatePostDateStruct date: 2024-03-04, sponsorCollaboratorsModule leadSponsor name: National Taiwan University Hospital, class: OTHER, descriptionModule briefSummary: The goal of this clinical interventional study is to compare the efficacy of mobile healthcare education in two ways (game-based or text-based) to improve cutaneous self-care capability in cancer patients receiving EGFR-based target therapy. The main questions it aims to answer are:Impact of different mobile healthcare education ways on cutaneous self-care capability of patients Impact of different mobile healthcare education ways on learning motivation of patients towards cutaneous self-care knowledge and skillsParticipants will be randomly divided into two groups. Both groups will download a healthcare education application on their phone. One group will accept the education about the knowledge and self-care skills of cutaneous adverse drug reaction by playing game. In contrast, the other group will accept the same education content by reading text on the phone. Subjects will be asked to use the application at home for two weeks after giving consent to participate this study, and then completed questionnaire three times during study period. The timepoints of completing questionnaire are listed following:Baseline / pre-intervention test (after signing informed consent form, D1) First post-intervention test (after finishing intervention, D15) Second post-intervention test (D30) Researchers will compare game group and text group to see if game group has better performance on cutaneous self-care capability and learning motivation., conditionsModule conditions: EGFR Gene Mutation, conditions: Drug-Related Side Effects and Adverse Reactions, conditions: Cancer, Treatment-Related, conditions: Cancer, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: OTHER, maskingInfo masking: SINGLE, whoMasked: PARTICIPANT, enrollmentInfo count: 110, type: ESTIMATED, armsInterventionsModule interventions name: Mobile healthcare education game, interventions name: Mobile healthcare education application, outcomesModule primaryOutcomes measure: Change from baseline in the score of cutaneous adverse drug reaction (CADR) knowledge on researcher-designed questionnaire at Day 15 and Day 30., secondaryOutcomes measure: Investigate the learning motivation towards CADR by self-designed questionnaire at Day 15, secondaryOutcomes measure: Change from baseline in the score of the quality of life on DLQI questionnaire at Day 15 and Day 30, secondaryOutcomes measure: Investigate the user-experience of the mobile healthcare education APP by researcher-designed questionnaire at Day 15., secondaryOutcomes measure: Change from baseline in the score of the self-care measurement adherence on researcher-designed questionnaire at Day 15 and Day30., otherOutcomes measure: The correlation among APP usability, learning motivation and self-care capability., eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: National Taiwan University Hospital, status: RECRUITING, city: Taipei, zip: 100225, country: Taiwan, contacts name: XinYi Lin, Bs, role: CONTACT, phone: +886988619601, email: [email protected], geoPoint lat: 25.04776, lon: 121.53185, hasResults: False |
protocolSection identificationModule nctId: NCT06291675, orgStudyIdInfo id: 2083/2022, briefTitle: Gender-Affirming Hormone Therapy and Its Impact on Myocardial Mass and Cardiac Function, Heart, Liver and Pancreatic Fat Content, statusModule overallStatus: RECRUITING, startDateStruct date: 2023-03-03, primaryCompletionDateStruct date: 2026-03-03, completionDateStruct date: 2033-03-03, studyFirstPostDateStruct date: 2024-03-04, lastUpdatePostDateStruct date: 2024-03-04, sponsorCollaboratorsModule leadSponsor name: Medical University of Vienna, class: OTHER, descriptionModule briefSummary: Background: Gender affirming hormone therapy (GAHT) leads to profound changes in sex hormone levels, carrying a wide range of implications for major physiological processes in the body. GAHT has been shown to be associated with changes in cardiovascular parameters, the insulin system, body composition, and the psychological state. However, despite the fact that GAHT is usually a long-term intervention, the majority of the research concerns itself with an overall short duration of the therapy and the data on the mid- to long-term effects of GAHT is scarce.Objectives: The study aims to investigate the effects of gender affirming hormone therapy on the cardiovascular risk profile, insulin system, body composition, various metabolic parameters, and the psychological state after 2, 5, and 10 years of the treatment.Study design: The study is designed as an observational longitudinal monocentric study, which includes transgender men and transgender women who have been taking gender affirming hormone therapy during the past 2 years and took part in our pilot study. Our probands will undergo a magnetic resonance scan, extensive bloodwork, an oral glucose tolerance test, and a psychological self-assessment after 2, 5, and 10 years of the treatment.Materials and methods: The magnetic resonance imaging and spectroscopy will be performed with a 3-Tesla magnetic resonance device. We will also perform an extensive blood analysis and an 75g- 2h oral glucose tolerance test. Additionally, the psychological state of the probands will be assessed with 3 questionnaires.Study population: 30 transgender men 30 transgender women who participated in our pilot study and have been taking the gender affirming hormone therapy for the past 2 years.Relevance and implications of the study: The majority of previous research has focused on the short-term effects of gender affirming hormone therapy. Contrastingly, our study aims to focus on the effects of hormone therapy at 2, 5 and 10 years after the beginning of the treatment. Moreover, our study group utilizes measurements of myocardial, hepatic, and pancreatic fat content as well as an MR-assisted measurement of cardiac function, which is a topic that has not been present in research into the effects of gender affirming hormone therapy outside of our pilot study., conditionsModule conditions: Gender Dysphoria, conditions: Hormone Therapy Induced Morphologic Change, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 50, type: ESTIMATED, armsInterventionsModule interventions name: gender-affirming hormone therapy, outcomesModule primaryOutcomes measure: Myocardial mass, primaryOutcomes measure: Cardiac function - LVEF, primaryOutcomes measure: cardiac function - cardiac output index, primaryOutcomes measure: Organ lipid content, primaryOutcomes measure: Subcutaneous to visceral fat ratio, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Chiari Stoffwechselambulanz, Medical University of Vienna, status: RECRUITING, city: Vienna, zip: 1090, country: Austria, contacts name: Carola Deischinger, MD PhD, role: CONTACT, phone: +43140400, phoneExt: 20690, email: [email protected], contacts name: Alexandra Kautzky-Willer, Prof, MD, role: CONTACT, email: [email protected], contacts name: Alexandra Kautzky-Willer, Prof, MD, role: PRINCIPAL_INVESTIGATOR, contacts name: Carola Deischinger, MD PhD, role: SUB_INVESTIGATOR, geoPoint lat: 48.20849, lon: 16.37208, hasResults: False |
protocolSection identificationModule nctId: NCT06291662, orgStudyIdInfo id: PRECISE_IC, briefTitle: Evaluation of Performance Characteristics and Applicability in Oncology of Devices Customized Medical Devices Made by 3D Printing, statusModule overallStatus: RECRUITING, startDateStruct date: 2021-01-01, primaryCompletionDateStruct date: 2024-12-31, completionDateStruct date: 2025-06-30, studyFirstPostDateStruct date: 2024-03-04, lastUpdatePostDateStruct date: 2024-03-04, sponsorCollaboratorsModule leadSponsor name: Kathleen McGreevy, class: OTHER, descriptionModule briefSummary: Technologies 3D are demonstrating enormous potential for innovation in the field of surgery,introducing the concept of "treatment customization" (from planning surgery to implant design and manufacturing) on the patient's anatomy, simply by taking advantage of the patient's own common diagnostic images and the flexibility of 3D printing. In fact, this new construction technology allows the construction of the complex anatomical geometries with economy, simplicity and on scales of production unattainable by other traditional technologies. This new construction technology allows, in fact, the construction of complex anatomical geometries with economy, simplicity and on scales of production unattainable by other traditional technologies., conditionsModule conditions: Sarcoma, conditions: Intracranial Neoplasm, conditions: Pelvic Bone Neoplasm, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NON_RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: Oncologic patients, primaryPurpose: OTHER, maskingInfo masking: NONE, enrollmentInfo count: 12, type: ESTIMATED, armsInterventionsModule interventions name: 3D printer applications, outcomesModule primaryOutcomes measure: 3D model feasibility for pre-surgical making decisions, primaryOutcomes measure: Surgical time, primaryOutcomes measure: Device feasibility, eligibilityModule sex: ALL, minimumAge: 7 Years, maximumAge: 70 Years, stdAges: CHILD, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Azienda Ospedaliero-Universitaria Careggi (AOUC), status: ACTIVE_NOT_RECRUITING, city: Firenze, country: Italy, geoPoint lat: 43.77925, lon: 11.24626, locations facility: Meyer Children's Hospital IRCCS, status: RECRUITING, city: Firenze, country: Italy, contacts name: Federico Mussa, MD, role: CONTACT, email: [email protected], geoPoint lat: 43.77925, lon: 11.24626, locations facility: Azienda Ospedaliero Universitaria Senese (AOUS), status: ACTIVE_NOT_RECRUITING, city: Siena, country: Italy, geoPoint lat: 43.31822, lon: 11.33064, hasResults: False |
protocolSection identificationModule nctId: NCT06291649, orgStudyIdInfo id: AMIETOX, briefTitle: Multicentre Prospective Observational Study of Acute Intoxications in Paediatric Age, statusModule overallStatus: RECRUITING, startDateStruct date: 2023-04-05, primaryCompletionDateStruct date: 2033-04-05, completionDateStruct date: 2033-08-05, studyFirstPostDateStruct date: 2024-03-04, lastUpdatePostDateStruct date: 2024-03-04, sponsorCollaboratorsModule leadSponsor name: Meyer Children's Hospital IRCCS, class: OTHER, descriptionModule briefSummary: Acute intoxications represent a major public health problem, especially when affect a population such as children, who are vulnerable and at greater risk of unintentional and preventable poisonings.The primary objective of the study is to assess the epidemiology of acute intoxications in paediatric age with respect to the social and care factors associated with it in order to then implement in the future a better diagnostic-therapeutic management modality on a national level.Thi is a prospective non-profit multicentre observational cohort study on acute intoxications in the paediatric age, conducted by AMIETOX, aimed at CAVs (Poison Control Centres) and PSPs (Paediatric emergency room)., conditionsModule conditions: Acute Intoxication, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 90, type: ESTIMATED, outcomesModule primaryOutcomes measure: Determination of Incidence of intoxication in paediatric children, primaryOutcomes measure: Determination of Prevalence of intoxication in paediatric children, eligibilityModule sex: ALL, minimumAge: 1 Month, maximumAge: 16 Years, stdAges: CHILD, contactsLocationsModule locations facility: Ospedale Santa Maria Annunziata, status: RECRUITING, city: Bagno A Ripoli, state: Firenze, zip: 50139, country: Italy, contacts name: Anna Chiara Azzali, role: CONTACT, phone: 055 69361, email: [email protected], geoPoint lat: 43.75115, lon: 11.32252, locations facility: Ospedale Del Mugello, status: RECRUITING, city: Borgo San Lorenzo, state: Firenze, zip: 50139, country: Italy, contacts name: Rosalia Emidia Di Silvio, role: CONTACT, email: [email protected], geoPoint lat: 43.95548, lon: 11.38561, locations facility: Ospedale G B Morgagni, status: RECRUITING, city: Forlì, state: Forlì-Cesena, country: Italy, contacts name: Melodie Aricò, role: CONTACT, email: [email protected], geoPoint lat: 44.22177, lon: 12.04144, locations facility: Mater Salutis, status: RECRUITING, city: Legnago, state: Verona, country: Italy, contacts name: Anna Maria Colombaria, role: CONTACT, email: [email protected], geoPoint lat: 45.19365, lon: 11.30227, locations facility: Ospedale Maggiore, status: RECRUITING, city: Bologna, country: Italy, contacts name: Chiara Ghizzi, role: CONTACT, email: [email protected], geoPoint lat: 44.49381, lon: 11.33875, locations facility: Ospedale Centrale Bolzano, status: RECRUITING, city: Bolzano, country: Italy, contacts name: Ylenia Girtler, role: CONTACT, email: [email protected], geoPoint lat: 46.49067, lon: 11.33982, locations facility: Ospedale Brotzu, status: RECRUITING, city: Cagliari, country: Italy, contacts name: Gabriella Cherchi, role: CONTACT, email: [email protected], geoPoint lat: 39.23054, lon: 9.11917, locations facility: Ospedale San Giuseppe, status: RECRUITING, city: Empoli, zip: 50053, country: Italy, contacts name: Antonino Francesco Capizzi, role: CONTACT, email: [email protected], geoPoint lat: 43.71795, lon: 10.94758, locations facility: Meyer Children's Hospital IRCCS, status: RECRUITING, city: Florence, zip: 50139, country: Italy, contacts name: Marco De Luca, role: CONTACT, phone: 0555662051, email: [email protected], geoPoint lat: 43.77925, lon: 11.24626, locations facility: Ospedale Misericordia, status: RECRUITING, city: Grosseto, zip: 58100, country: Italy, contacts name: Francesca Bonsignori, role: CONTACT, email: [email protected], geoPoint lat: 42.76296, lon: 11.10941, locations facility: Policlinico Messina, status: RECRUITING, city: Messina, country: Italy, contacts name: Laura Colavita, role: CONTACT, email: [email protected], geoPoint lat: 38.19394, lon: 15.55256, locations facility: Ospedale San Francesco, status: RECRUITING, city: Nuoro, country: Italy, contacts name: Antonio Cualbu, role: CONTACT, email: [email protected], geoPoint lat: 40.31991, lon: 9.32568, locations facility: Ao Padova, status: RECRUITING, city: Padova, country: Italy, contacts name: Francesco Corazza, role: CONTACT, email: [email protected], geoPoint lat: 45.40797, lon: 11.88586, locations facility: Nuovo Ospedale Dei Bambini, status: RECRUITING, city: Parma, country: Italy, contacts name: Monica Rubini, role: CONTACT, email: [email protected], geoPoint lat: 44.79935, lon: 10.32618, locations facility: Policlinico San Matteo, status: RECRUITING, city: Pavia, country: Italy, contacts name: Thomas Foiadelli, role: CONTACT, email: [email protected], geoPoint lat: 45.19205, lon: 9.15917, locations facility: Policlinico Pescara, status: RECRUITING, city: Pescara, country: Italy, contacts name: Giorgia Carlone, role: CONTACT, email: [email protected], geoPoint lat: 42.4584, lon: 14.20283, locations facility: Ospedale Santa Chiara - Cisanello, status: RECRUITING, city: Pisa, country: Italy, contacts name: Alessandro Orsini, role: CONTACT, email: [email protected], geoPoint lat: 43.70853, lon: 10.4036, locations facility: Ospedale San Jacopo, status: RECRUITING, city: Pistoia, zip: 51100, country: Italy, contacts name: Francesca Mangiantini, role: CONTACT, email: [email protected], geoPoint lat: 43.93064, lon: 10.92365, locations facility: Ospedale Civile Santa Maria Degli Angel, status: RECRUITING, city: Pordenone, country: Italy, contacts name: Daniele Santori, role: CONTACT, email: [email protected], geoPoint lat: 45.95689, lon: 12.66051, locations facility: Ospedale Santo Stefano, status: RECRUITING, city: Prato, zip: 59100, country: Italy, contacts name: Francesca Grisolia, role: CONTACT, email: [email protected], geoPoint lat: 43.8805, lon: 11.09699, locations facility: Ospedale Infermi, status: RECRUITING, city: Rimini, country: Italy, contacts name: Gianluca Vergine, role: CONTACT, email: [email protected], geoPoint lat: 44.05755, lon: 12.56528, locations facility: CAV Gemelli, status: RECRUITING, city: Roma, country: Italy, contacts name: Maurizio Paolo Soave, role: CONTACT, email: [email protected], geoPoint lat: 41.89193, lon: 12.51133, locations facility: Policlinico Gemelli, status: RECRUITING, city: Roma, country: Italy, contacts name: Antonio Gatto, role: CONTACT, email: [email protected], geoPoint lat: 41.89193, lon: 12.51133, locations facility: Ospedale Regina Margherita, status: RECRUITING, city: Torino, country: Italy, contacts name: Claudia Bondone, role: CONTACT, email: [email protected], geoPoint lat: 45.07049, lon: 7.68682, locations facility: Santa Chiara, status: RECRUITING, city: Trento, country: Italy, contacts name: Stefania Ielo, role: CONTACT, email: [email protected], geoPoint lat: 46.06787, lon: 11.12108, locations facility: Ulss 2 Marca Trevigiana, status: RECRUITING, city: Treviso, country: Italy, contacts name: Valentina Brugnarolo, role: CONTACT, email: [email protected], geoPoint lat: 45.66673, lon: 12.2416, locations facility: Burlo Garofalo, status: RECRUITING, city: Trieste, country: Italy, contacts name: Alessandro Amaddeo, role: CONTACT, email: [email protected], geoPoint lat: 45.64953, lon: 13.77679, locations facility: Clinica Pediatrica Udine, status: RECRUITING, city: Udine, country: Italy, contacts name: Chiara Pilotto, role: CONTACT, email: [email protected], geoPoint lat: 46.0693, lon: 13.23715, locations facility: CAV Veneto, status: RECRUITING, city: Verona, country: Italy, contacts name: Giorgio Ricci, role: CONTACT, email: [email protected], geoPoint lat: 45.4299, lon: 10.98444, locations facility: Ospedale Della Donna E Del Bambino, status: RECRUITING, city: Verona, country: Italy, contacts name: Pietro Soloni, role: CONTACT, email: [email protected], geoPoint lat: 45.4299, lon: 10.98444, locations facility: Ospedale San Bortolo, status: RECRUITING, city: Vicenza, country: Italy, contacts name: Ilaria Tosetto, role: CONTACT, email: [email protected], geoPoint lat: 45.54672, lon: 11.5475, hasResults: False |
protocolSection identificationModule nctId: NCT06291636, orgStudyIdInfo id: R.24.01.2451, briefTitle: Re- Admission Rate Among Survived Patients With Acute Respiratory Failure, statusModule overallStatus: COMPLETED, startDateStruct date: 2023-01-01, primaryCompletionDateStruct date: 2023-12-31, completionDateStruct date: 2024-01-20, studyFirstPostDateStruct date: 2024-03-04, lastUpdatePostDateStruct date: 2024-03-04, sponsorCollaboratorsModule leadSponsor name: Mansoura University, class: OTHER, descriptionModule briefSummary: Readmission to the intensive care unit (ICU) results in increased consumption of medical resources and costs, and has been proposed as a marker for quality of care. ICU readmission rates have been estimated at 4 to 14% and different risk factors have been proposed by various studies Readmitted patients mostly carry poor prognosis compared to newly admitted ones, in addition to the bad psychological impact for both patient and his family, conditionsModule conditions: Respiratory Failure, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: RETROSPECTIVE, enrollmentInfo count: 994, type: ACTUAL, outcomesModule primaryOutcomes measure: Length of hospital and ICU stay and Cause of readmission, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Tamer Awad Elsayed, city: Mansoura, state: Dakhlia, zip: 050, country: Egypt, geoPoint lat: 31.03637, lon: 31.38069, hasResults: False |
protocolSection identificationModule nctId: NCT06291623, orgStudyIdInfo id: Molecular Analysis, briefTitle: Molecular Analysis of Intracanal Microbes After Chemomechanical Procedure and Root Canal Medication: Clinical Study, statusModule overallStatus: COMPLETED, startDateStruct date: 2022-05-03, primaryCompletionDateStruct date: 2023-12-20, completionDateStruct date: 2024-01-15, studyFirstPostDateStruct date: 2024-03-04, lastUpdatePostDateStruct date: 2024-03-04, sponsorCollaboratorsModule leadSponsor name: Mansoura University, class: OTHER, descriptionModule briefSummary: This study aimed to evaluate clinically the intracanal microbes at molecular level after using established root canal medicament Calcium hydroxide and potential root canal medicament Glycyrrhizin.and Decontamination Analysis of Controls samples., conditionsModule conditions: Bacterial Viability of Necrotic Pulp With Asymptomatic Apical Periodontitis, designModule studyType: INTERVENTIONAL, phases: PHASE1, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: SINGLE, whoMasked: PARTICIPANT, enrollmentInfo count: 20, type: ACTUAL, armsInterventionsModule interventions name: Glycyrrhizin, outcomesModule primaryOutcomes measure: minimizing of viable bacteria which showed by Real time PCR, eligibilityModule sex: ALL, minimumAge: 19 Years, maximumAge: 60 Years, stdAges: ADULT, contactsLocationsModule locations facility: Mansoura University, city: Mansoura, state: Dakahliya, zip: 35511, country: Egypt, geoPoint lat: 31.03637, lon: 31.38069, hasResults: False |
protocolSection identificationModule nctId: NCT06291610, orgStudyIdInfo id: Aarhus University Hospital, briefTitle: Feasibility Testing a Decision-support Intervention for Clinical Trials, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-02-19, primaryCompletionDateStruct date: 2025-12-31, completionDateStruct date: 2026-12-31, studyFirstPostDateStruct date: 2024-03-04, lastUpdatePostDateStruct date: 2024-03-04, sponsorCollaboratorsModule leadSponsor name: University of Aarhus, class: OTHER, descriptionModule briefSummary: A decision-support intervention are developed for a Danish nationwide randomised controlled trial (RCT) among patients with laryngeal and pharyngeal cancer referred to curative intended radiotherapy. The primary endpoints in this RCT are levels of dysphagia and xerostomia.The decision-support intervention consists of three components, including (1) a patient decision aid tailored to clinical trial participation and (2) decision coaching consultations carried out by trained healthcare professionals. Finally, (3) a training program in decision coaching will be an integrated part of the intervention.To feasibility test (beta test) the intervention, 60 patient participants will be included, separated into pre- (n=30) and post- (n=30) intervention groups. Pre-intervention to complete the survey based on current clinical practice. Post-intervention to complete the survey following engagement in the decision support intervention.A total of 12 physicians will be recruited and trained in decision coaching. To assess the acceptability of the intervention, the physicians will be interviewed. Additionally, they will be asked to audio-record two decision coaching sessions to test the fidelity of the intervention., conditionsModule conditions: Head and Neck Neoplasms, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NA, interventionModel: SINGLE_GROUP, interventionModelDescription: Pre- and post-intervention measures in two consecutive groups., primaryPurpose: HEALTH_SERVICES_RESEARCH, maskingInfo masking: NONE, maskingDescription: Patients are recruited anonymous, enrollmentInfo count: 60, type: ESTIMATED, armsInterventionsModule interventions name: Clinical trial decision support intervention, outcomesModule primaryOutcomes measure: Decisional conflict scale, primaryOutcomes measure: The decision preparation scale, secondaryOutcomes measure: The stages of decision making measure, secondaryOutcomes measure: Items on health literacy, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Aarhus University Hospital, status: RECRUITING, city: Aarhus, zip: 8200, country: Denmark, contacts name: Anne Kristensen, role: CONTACT, phone: +4530315605, email: [email protected], contacts name: Cai Grau, role: CONTACT, email: [email protected], geoPoint lat: 56.15674, lon: 10.21076, hasResults: False |
protocolSection identificationModule nctId: NCT06291597, orgStudyIdInfo id: 22071, briefTitle: Vaping Adverse Lung and Heart Events Cohort, acronym: VapALERT, statusModule overallStatus: RECRUITING, startDateStruct date: 2021-10-14, primaryCompletionDateStruct date: 2031-12, completionDateStruct date: 2032-06, studyFirstPostDateStruct date: 2024-03-04, lastUpdatePostDateStruct date: 2024-03-04, sponsorCollaboratorsModule leadSponsor name: Laval University, class: OTHER, collaborators name: Ministere de la Sante et des Services Sociaux, descriptionModule briefSummary: This prospective study assesses the pulmonary and cardiovascular effets of vaping in adult electronic cigarette users with biannual visits and a 5-year follow-up., conditionsModule conditions: Vaping, conditions: Electronic Cigarette Use, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 250, type: ESTIMATED, armsInterventionsModule interventions name: Vaping, outcomesModule primaryOutcomes measure: Number of participants who vape daily with impaired lung volumes., primaryOutcomes measure: Number of participants who vape daily with impaired lung diffusion capacity., primaryOutcomes measure: Number of participants who vape daily with impaired spirometry., primaryOutcomes measure: Number of participants who vape daily with airway hyperresponsiveness., primaryOutcomes measure: Number of participants who vape daily with changes in blood cell count., primaryOutcomes measure: Number of participants who vape daily with changes in sputum cell count., primaryOutcomes measure: Vaping, tobacco and cannabis smoking habits of participants., eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: IUCPQ-UL, status: RECRUITING, city: Québec, zip: G1V 4G5, country: Canada, contacts name: Ariane Lechasseur, PhD, role: CONTACT, phone: 418-656-8711, phoneExt: 2652, email: [email protected], contacts name: Mathieu C Morissette, PhD, role: PRINCIPAL_INVESTIGATOR, contacts name: Andréanne Côté, MD, MSc, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 46.81228, lon: -71.21454, hasResults: False |
protocolSection identificationModule nctId: NCT06291584, orgStudyIdInfo id: P20230001, briefTitle: Effects of Exercises on Functional Capacity, statusModule overallStatus: RECRUITING, startDateStruct date: 2023-10-01, primaryCompletionDateStruct date: 2024-05-01, completionDateStruct date: 2024-10-01, studyFirstPostDateStruct date: 2024-03-04, lastUpdatePostDateStruct date: 2024-03-08, sponsorCollaboratorsModule leadSponsor name: Kırklareli University, class: OTHER, descriptionModule briefSummary: In this study, the researchers aim to investigate the effects of strengthening and respiratory exercises on the face and online on functional capacity., conditionsModule conditions: Nicotine Addiction, conditions: Respiratory Disease, conditions: Sedentary Behavior, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: The study consists of three groups. Groups to be formed: Group 1: face-to-face exercise group; Group 2: Online (Telehealth) Exercise Group; Group 3: Control Group, primaryPurpose: TREATMENT, maskingInfo masking: SINGLE, maskingDescription: First of all, the randomization of exercise groups will be performed according to the closed envelope procedure. The student who selects one of the envelopes with the names of the three groups will be included in the group written in the envelope he selected., whoMasked: PARTICIPANT, enrollmentInfo count: 60, type: ESTIMATED, armsInterventionsModule interventions name: Exercise, outcomesModule primaryOutcomes measure: International Physical Activity Questionnaire - Short Form, primaryOutcomes measure: Six-Minute Walk Test- (6MWT), eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 40 Years, stdAges: ADULT, contactsLocationsModule locations facility: Kirklareli University, status: RECRUITING, city: Kırklareli, state: Kayalı, zip: 39000, country: Turkey, contacts name: Fulya DEMIRHAN, Res. Ass., role: CONTACT, phone: +90-532-353-2208, email: [email protected], geoPoint lat: 41.73508, lon: 27.22521, hasResults: False |
protocolSection identificationModule nctId: NCT06291571, orgStudyIdInfo id: 324543, briefTitle: Assessment of Microorganisms and Host Response In Liver Diseases, acronym: MILD, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-03-01, primaryCompletionDateStruct date: 2029-02-28, completionDateStruct date: 2030-03-01, studyFirstPostDateStruct date: 2024-03-04, lastUpdatePostDateStruct date: 2024-03-04, sponsorCollaboratorsModule leadSponsor name: University of Aberdeen, class: OTHER, descriptionModule briefSummary: The normal human gut is home to millions of microbes including bacteria, fungi, and viruses, collectively forming the gut microbiota, which exists in harmony within us. Much research is still required to fully understand the contribution of microbes resident in the large intestine in liver diseases. The liver receives blood from the gut carrying all the necessary nutrients needed for our body but also has to deal with toxins derived from the microbes residing in the intestines. The gut microbiota is altered in liver disease. We still do not know clearly how this change impacts liver function and the health of liver patients. The purpose of our study is to answer this question by assessing the gut microbiota using modern microbiological and molecular methods. By studying the alterations in the gut microbiota in patients with liver disease we can understand how they affect our immune system and metabolism. This will help design novel medicinal products to prevent and treat liver disease., conditionsModule conditions: Gut Microbiome, conditions: Liver Diseases, designModule studyType: OBSERVATIONAL, designInfo observationalModel: CASE_CONTROL, timePerspective: PROSPECTIVE, enrollmentInfo count: 200, type: ESTIMATED, armsInterventionsModule, outcomesModule primaryOutcomes measure: To identify the bacterial, fungal, and virological agents present in patients with liver disease as opposed to controls, secondaryOutcomes measure: To assess the host immune response against specific microbes isolated from patients with liver disease and controls, secondaryOutcomes measure: To characterise the changes in the liver immune microenvironment by analysing liver biopsies from patients, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 70 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False |
protocolSection identificationModule nctId: NCT06291558, orgStudyIdInfo id: P202200027, briefTitle: Exercise Training for Smoking Students, statusModule overallStatus: RECRUITING, startDateStruct date: 2023-10-01, primaryCompletionDateStruct date: 2024-05-01, completionDateStruct date: 2024-10-01, studyFirstPostDateStruct date: 2024-03-04, lastUpdatePostDateStruct date: 2024-03-04, sponsorCollaboratorsModule leadSponsor name: Kırklareli University, class: OTHER, descriptionModule briefSummary: Smoking can damage lung functions as a result of high carbon monoxide and low hemoglobin oxygen carrying capacity in the blood. Smoking between young people continues to increase, which can cause respiratory function problems and lung diseases at an early age. In the studies, it has been seen that smoking may reduce the oppression and exercise ability., conditionsModule conditions: Nicotine Dependence, conditions: Smoking, conditions: Physical Inactivity, conditions: Depression, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: PREVENTION, maskingInfo masking: SINGLE, maskingDescription: The participants will be informed that the study was carried out for scientific purposes and the information will not be shared with third parties. Randomization of exercise groups will be performed according to the closed envelope procedure. The student who selects one of the envelopes with the names of the 3 groups will be included in the group written in the envelope he selected. Information about other groups will not be shared., whoMasked: PARTICIPANT, enrollmentInfo count: 60, type: ESTIMATED, armsInterventionsModule interventions name: Exercise, outcomesModule primaryOutcomes measure: International Physical Activity Questionnaire (Short), primaryOutcomes measure: Six-Minute Walk Test, primaryOutcomes measure: Scoring the Fagerstrom Test for Nicotine Dependence (FTND), primaryOutcomes measure: Beck's Depression Inventory (BDI), primaryOutcomes measure: Lung Function Test, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 40 Years, stdAges: ADULT, contactsLocationsModule locations facility: Kirklareli University, status: RECRUITING, city: Kırklareli, state: Kayalı, zip: 39000, country: Turkey, contacts name: Fulya DEMIRHAN, Res. Ass., role: CONTACT, phone: +90-532-353-2208, email: [email protected], geoPoint lat: 41.73508, lon: 27.22521, hasResults: False |
protocolSection identificationModule nctId: NCT06291545, orgStudyIdInfo id: JW-SBC202202, briefTitle: Effectiveness and Safety of Coronary Scoring Balloon Dilation Catheter in the Pretreatment of Coronary Stenosis Lesions, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-03-20, primaryCompletionDateStruct date: 2024-12-31, completionDateStruct date: 2025-06-30, studyFirstPostDateStruct date: 2024-03-04, lastUpdatePostDateStruct date: 2024-03-05, sponsorCollaboratorsModule leadSponsor name: JW Medical Systems Ltd, class: INDUSTRY, descriptionModule briefSummary: This trial adopts a prospective, multicenter, randomized controlled, and non-inferiority comparison trial design, and plans to recruit 200 eligible subjects who will be randomly assigned to the experimental group or the control group in a 1:1 ratio. All randomly enrolled subjects will be followed up until 30 days after the surgery., conditionsModule conditions: Coronary Artery Disease, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 200, type: ESTIMATED, armsInterventionsModule interventions name: Coronary artery scoring balloon dilation catheter（JW Medical Systems Ltd）, interventions name: ScoreFlex NC Coronary Dilatation Catheter, outcomesModule primaryOutcomes measure: Rate of successful device usage, secondaryOutcomes measure: Rate of success of the surgery, secondaryOutcomes measure: Incidence of in-hospital MACE, secondaryOutcomes measure: Incidence of PoCE within 30 days after surgery, secondaryOutcomes measure: The lumen is obtained immediately, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 80 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False |
protocolSection identificationModule nctId: NCT06291532, orgStudyIdInfo id: VRRS01, briefTitle: Feasibility and Usability of a Virtual Reality System, statusModule overallStatus: ENROLLING_BY_INVITATION, startDateStruct date: 2023-04-01, primaryCompletionDateStruct date: 2025-09-30, completionDateStruct date: 2025-09-30, studyFirstPostDateStruct date: 2024-03-04, lastUpdatePostDateStruct date: 2024-03-04, sponsorCollaboratorsModule leadSponsor name: IRCCS Centro Neurolesi "Bonino-Pulejo", class: OTHER, descriptionModule briefSummary: Intellectual disability (ID) and autism spectrum disorder (ASD) are often co-occurring neurodevelopmental disorders that require composite intervention. However, standardized rehabilitation programs presented several limitations due to behavioral problems and poor engagement in proposed activity. The Virtual Reality Rehabilitation System (VRRS) is a medical device is recognized as one of the most advanced systems to rehabilitate patients with motor, cognitive, linguistic and behavioral disorders. The use of VRRS offers the opportunity to adapting task parameters according to the patient's performance and the virtual system increases engagement and avoids boredom and frustration. the patients underwent a two months experimental intervention integrated into the regular activity of a semi-residential center for autistic adolescents and young adults., conditionsModule conditions: Autism Spectrum Disorder, conditions: Intellectual Disability, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NA, interventionModel: SINGLE_GROUP, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 100, type: ESTIMATED, armsInterventionsModule interventions name: Rehabilitation with VRRS, outcomesModule primaryOutcomes measure: Usability questionnaire, primaryOutcomes measure: Virtual Reality Rehabilitation System (VRRS) electromedical device parameters: screen attention time, primaryOutcomes measure: Virtual Reality Rehabilitation System (VRRS) electromedical device parameters: the number of repetitions of the exercises., primaryOutcomes measure: Virtual Reality Rehabilitation System (VRRS) electromedical device parameters:global scores for exercise., eligibilityModule sex: ALL, minimumAge: 6 Years, maximumAge: 40 Years, stdAges: CHILD, stdAges: ADULT, contactsLocationsModule locations facility: IRCCS Centro Neurolesi Bonino Pulejo, city: Messina, zip: 98124, country: Italy, geoPoint lat: 38.19394, lon: 15.55256, hasResults: False |
protocolSection identificationModule nctId: NCT06291519, orgStudyIdInfo id: SHN50343434, briefTitle: The Effect of Multisensory Stimulus Method on Pain and Physiological Parameters in Infants, statusModule overallStatus: COMPLETED, startDateStruct date: 2023-01-01, primaryCompletionDateStruct date: 2023-12-30, completionDateStruct date: 2023-12-30, studyFirstPostDateStruct date: 2024-03-04, lastUpdatePostDateStruct date: 2024-03-04, sponsorCollaboratorsModule leadSponsor name: Istanbul University - Cerrahpasa (IUC), class: OTHER, descriptionModule briefSummary: This study aimed to investigate the impact of employing the multi-sensory stimulation technique by both the mother and the nurse on the pain and physiological responses of infants aged 2-6 months during vaccination. The significance of pain experienced during vaccination in children is emphasized, potentially leading to avoidance behaviors toward healthcare services. There is growing evidence supporting the efficacy of non-pharmacological interventions. Multi-sensory stimulation, which integrates various stimuli such as taste, touch, and speech, alleviates infant pain. However, there has been a lack of studies assessing the effectiveness of this approach during vaccination administered by different healthcare providers. Hence, this study sought to explore the effects of multi-sensory stimulation by both mother and nurse applied to pain and physiological parameters. It is anticipated that the findings of this study will contribute to both pain management strategies and healthcare practices., conditionsModule conditions: Multisensory Stimulation, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: Randomized controlled experimental design, primaryPurpose: HEALTH_SERVICES_RESEARCH, maskingInfo masking: NONE, enrollmentInfo count: 96, type: ACTUAL, armsInterventionsModule interventions name: Multi-sensory Stimulation Method-Mother Applying the Method to the Baby, interventions name: Multi-sensory Stimulation Method-Nurse Applying the Method to the Baby, interventions name: Breastfeeding Applied Group, outcomesModule primaryOutcomes measure: The Effect of Multiple Sensory Stimulus Method, secondaryOutcomes measure: Comparison of the group in which the mother applied multiple sensory stimuli and the group in which the nurse applied multiple sensory stimuli, eligibilityModule sex: ALL, minimumAge: 2 Months, maximumAge: 6 Months, stdAges: CHILD, contactsLocationsModule locations facility: Istanbul University-Cerrahpasa, city: Istanbul, state: None Selected, zip: 34381, country: Turkey, geoPoint lat: 41.01384, lon: 28.94966, hasResults: False |
protocolSection identificationModule nctId: NCT06291506, orgStudyIdInfo id: 6270, briefTitle: SUbstrate Ablation in Persistent Atrial Fibrillation for Elimination of Recurrences (SUPAFER)., acronym: SUPAFER, statusModule overallStatus: RECRUITING, startDateStruct date: 2023-05-01, primaryCompletionDateStruct date: 2026-05-01, completionDateStruct date: 2026-05-01, studyFirstPostDateStruct date: 2024-03-04, lastUpdatePostDateStruct date: 2024-03-04, sponsorCollaboratorsModule leadSponsor name: Hospital Universitario La Paz, class: OTHER, descriptionModule briefSummary: Antecedents: electrical isolation of pulmonary veins is the standard treatment for patients with atrial fibrillation. However, its efficacy is lower in persistent and chronic forms of this arrhythmia compared to paroxysmal atrial fibrillation. Many complementary techniques have been proposed, that added to pulmonary veins isolation, may reduce the recurrence rate of atrial fibrillation. However, none of them has obtained consistent results. Linear ablation aims to parcellate and modify the left atrial substrate responsible for atrial fibrillation maintenance. Previous studies have offered contradictory results using linear ablation.Methods: SUPAFER is a multicenter, 1:1 randomized clinical trial that compares the efficacy of pulmonary veins isolation alone vs pulmonary vein isolation plus an specific protocol of left atrial linear ablation. Contrary to previous studies, the specific SUPAFER linear ablation is systematic, homogeneous and target atrial areas that have not been systematically ablated in previous trials. The trial aims at demonstrating the superiority of the combined ablative approach during 1-year follow-up. Daily transtelephonic ECG samples a 30 days continuous ECG monitoring are used to maximize de detection of recurrences, even asymptomatic., conditionsModule conditions: Persistent and Long Lasting or Chronic Atrial Fibrillation, conditions: Atrial Fibrillation Ablation, conditions: Linear Left Atrial Ablation, conditions: Daily Transtelephonic Electrocardiogram, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: 1:1 randomization, primaryPurpose: TREATMENT, maskingInfo masking: SINGLE, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 176, type: ESTIMATED, armsInterventionsModule interventions name: Radiofrequency ablation of heart atrial tissue., outcomesModule primaryOutcomes measure: Recurrences of sustained >30 secons atrial arrhythmias measured by daily ECG samples (Kardia Alivecor) and 30 days continuous Holter., secondaryOutcomes measure: Acute intraprocedure efficacy., secondaryOutcomes measure: Complications., eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: La Paz University Hospital - IdiPaz, status: RECRUITING, city: Madrid, country: Spain, contacts name: José Luis Merino, MD, role: CONTACT, phone: +34 912071301, email: [email protected], contacts name: Sergio Castrejón Castrejón, role: SUB_INVESTIGATOR, geoPoint lat: 40.4165, lon: -3.70256, hasResults: False |
protocolSection identificationModule nctId: NCT06291493, orgStudyIdInfo id: CS-2024-0002, briefTitle: Precision Study Measuring Potassium (K) in Capillary Specimens, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-06, primaryCompletionDateStruct date: 2024-10, completionDateStruct date: 2024-12, studyFirstPostDateStruct date: 2024-03-04, lastUpdatePostDateStruct date: 2024-03-22, sponsorCollaboratorsModule leadSponsor name: Abbott Point of Care, class: INDUSTRY, descriptionModule briefSummary: Assessing precision of i-STAT K test using the IUO i-STAT CG8+ cartridge on the i-STAT 1 Analyzer., conditionsModule conditions: Precision of Potassium (K) Test in Capillary Whole Blood, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NA, interventionModel: SINGLE_GROUP, interventionModelDescription: Capillary precision analysis will be performed for Potassium K., primaryPurpose: DIAGNOSTIC, maskingInfo masking: NONE, enrollmentInfo count: 150, type: ESTIMATED, armsInterventionsModule interventions name: Fingerstick blood draw, outcomesModule primaryOutcomes measure: Precision for Potassium (K) Test, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False |
protocolSection identificationModule nctId: NCT06291480, orgStudyIdInfo id: NL78853.058.22 / STRUM, briefTitle: Music Therapy After Stroke (Subacute Phase), statusModule overallStatus: RECRUITING, startDateStruct date: 2023-01-01, primaryCompletionDateStruct date: 2024-08, completionDateStruct date: 2024-12, studyFirstPostDateStruct date: 2024-03-04, lastUpdatePostDateStruct date: 2024-03-04, sponsorCollaboratorsModule leadSponsor name: Universiteit Leiden, class: OTHER, collaborators name: Amstelring, descriptionModule briefSummary: The goal of this longitudinal, single-subject study is to investigate the role of motivation in music therapy for stroke patients within the subacute phase, who experience upper limb and/or attention deficits. The main questions it aims to answer are:* Does music therapy increase patient's motivation to rehabilitate?* Do increases in motivation correlate with functional improvements, in particular upper limb and/or attention skills?Participants will receive up to 9 music therapy sessions within 3-5 weeks, with functional assessments before and after each period. Each participant serves as their own comparison: researchers will compare a period with standard care only (control phase) to a period with music therapy plus standard care (intervention phase), the order of which will be randomized in advance., conditionsModule conditions: Stroke (CVA) or TIA, conditions: Stroke/Brain Attack, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: CROSSOVER, primaryPurpose: TREATMENT, maskingInfo masking: SINGLE, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 20, type: ESTIMATED, armsInterventionsModule interventions name: Neurologic Music Therapy, outcomesModule primaryOutcomes measure: Motivation: Brain Injury Rehabilitation Trust Motivation Questionnaire (BMQ-S) [self-reported], secondaryOutcomes measure: Motor Function: Action Research Arm Test (ARAT), secondaryOutcomes measure: Motor Function: Barthel Index (BI), secondaryOutcomes measure: Cognition: Cancellation Wechsler Adult Intelligence Scale (WAIS-IV), secondaryOutcomes measure: Cognition: Color-Word Interference Test, also known as Stroop test, secondaryOutcomes measure: Cognition: WAIS IV Digit Span Test - Forward and Backward, secondaryOutcomes measure: Cognition: Verbal Fluency Test, secondaryOutcomes measure: Cognition: Trail Making Test (TMT), otherOutcomes measure: Motivation to engage in musical activities: Barcelona Music Reward Questionnaire (BMRQ), otherOutcomes measure: Quality of Life: EuroQol-5 (EQ-5D-5L), otherOutcomes measure: Mood: Depression Anxiety Stress Scale-21 (DASS-21), otherOutcomes measure: Mood: Visual Analogue Mood Scale (VAMS), otherOutcomes measure: Personality Traits: The Big Five Index-Extra Short Form (BFI-2-XS), otherOutcomes measure: Optimism: Life Orientation Test- Revised (LOT-R), otherOutcomes measure: Brief self-report of therapy expectations and satisfaction with treatment, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Leo Polak Rehabilitation centre, status: RECRUITING, city: Amsterdam, state: Nederland, zip: 1069BW, country: Netherlands, contacts name: Theo Dimitriadis, MSc, role: CONTACT, email: [email protected], geoPoint lat: 52.37403, lon: 4.88969, hasResults: False |
protocolSection identificationModule nctId: NCT06291467, orgStudyIdInfo id: RECHMPL23_0121, briefTitle: Plasma Beta-endorphin Levels and Suicidal Behavior, acronym: BEST, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-03, primaryCompletionDateStruct date: 2026-03, completionDateStruct date: 2026-03, studyFirstPostDateStruct date: 2024-03-04, lastUpdatePostDateStruct date: 2024-03-04, sponsorCollaboratorsModule leadSponsor name: University Hospital, Montpellier, class: OTHER, collaborators name: Institut de Génomique Fonctionnelle (IGF) de Montpellier, descriptionModule briefSummary: It is an interventional research, monocentric, which involves only minimal risks and constraints.Psychological pain is closely associated with suicidal ideation (SI) and suicidal behavior, regardless of the severity of the depression. The psychological pain being regulated by the opioidergic system, it seems that a dysfunction of this system exists in suicidal attempters. The aim of this study is to explore the association between levels of β-endorphin and suicidal behavior.The research team will measure plasma levels of β-endorphin in patients hospitalized for suicide attempt (SA) within 72 hours and compare them to those of patients hospitalized for current major depressive episode (EDC) without any lifetime history of SA. In order to follow the kinetics of β endorphin levels, The research team will carry out two measurements: at inclusion and on day 7 (+/- 2 days) of inclusion.The main objective is to compare plasma β-endorphin levels in patients hospitalized following a recent SA (≤72 hours) and in patients hospitalized for an EDC without lifetime history of SA., conditionsModule conditions: Suicide, conditions: Depression, conditions: Beta Endorphin, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NON_RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: OTHER, maskingInfo masking: NONE, enrollmentInfo count: 104, type: ESTIMATED, armsInterventionsModule interventions name: Blood samples, interventions name: questionnaires, outcomesModule primaryOutcomes measure: Comparison of plasma β-endorphin levels between patients with recent suicide attempt (≤ 72 hours) vs. patients with current major depressive episode without any lifetime history of suicide attempt., secondaryOutcomes measure: - The kinetics of β-endorphin levels between two measurement points (inclusion and D7+/-2 days) in patients with recent suicide attempt (≤ 72 hours) vs. patients with current major depressive episode without any history of suicide attempt., secondaryOutcomes measure: The level of depression in the last week before inclusion assessed by a self-administered questionnaire (MADRS), secondaryOutcomes measure: The level of depression in the last week before inclusion assessed by a self-administered questionnaire (QIDS-16), secondaryOutcomes measure: To assess the association between β-endorphin levels and and Suicidal ideation and history of suicidal behavior in the last week before inclusion,, secondaryOutcomes measure: To assess the association between β-endorphin levels and Anhedonia, secondaryOutcomes measure: To assess the association between β-endorphin levels and Current psychological and physical pain as well as usual and maximum over the 15 days before inclusion, secondaryOutcomes measure: To assess the association between β-endorphin levels and Anxiety,, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 65 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: University hospital, city: Montpellier, zip: 34295, country: France, contacts name: Jessica DALAUDIERE, role: CONTACT, email: [email protected], geoPoint lat: 43.61092, lon: 3.87723, hasResults: False |
protocolSection identificationModule nctId: NCT06291454, orgStudyIdInfo id: 741100, briefTitle: GCF Levels of Chemokines in Periodontitis, statusModule overallStatus: COMPLETED, startDateStruct date: 2023-01-01, primaryCompletionDateStruct date: 2023-12-01, completionDateStruct date: 2023-12-01, studyFirstPostDateStruct date: 2024-03-04, lastUpdatePostDateStruct date: 2024-03-08, sponsorCollaboratorsModule leadSponsor name: T.C. ORDU ÜNİVERSİTESİ, class: OTHER, descriptionModule briefSummary: This study aimed to determine CCL19/MIP3beta(β) and CCL20/MIP3alpha(α) in the gingival crevicular fluid (GCF) of the patients with different periodontitis phenotypes.A total of 72 individuals, 24 with Stage III Grade B periodontitis (Group 1), 24 with Stage III Grade C periodontitis (Group 2), and 24 periodontally healthy (control group) (Group 3), were included in the study. GCF and clinical periodontal parameters were obtained at baseline. MIP3β and MIP3α levels in GCF were determined by ELISA., conditionsModule conditions: Periodontal Diseases, designModule studyType: OBSERVATIONAL, designInfo observationalModel: CASE_CONTROL, timePerspective: PROSPECTIVE, enrollmentInfo count: 72, type: ACTUAL, armsInterventionsModule interventions name: Routine periodontal examination, outcomesModule primaryOutcomes measure: CCL19/MIP3beta(β) levels, primaryOutcomes measure: CCL20/MIP3alpha(α) levels, secondaryOutcomes measure: CCL19/MIP3beta(β) levels and clinical parameters, secondaryOutcomes measure: CCL20/MIP3alpha(α) levels and clinical parameters, eligibilityModule sex: ALL, minimumAge: 22 Years, maximumAge: 55 Years, stdAges: ADULT, contactsLocationsModule locations facility: Ordu University, Faculty of Dentistry, city: Ordu, zip: 52100, country: Turkey, geoPoint lat: 40.97782, lon: 37.89047, hasResults: False |
protocolSection identificationModule nctId: NCT06291441, orgStudyIdInfo id: WUIPS, briefTitle: Women Urinary Incontinence Prevalence Study (WUIPS), statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-03, primaryCompletionDateStruct date: 2025-06, completionDateStruct date: 2025-12, studyFirstPostDateStruct date: 2024-03-04, lastUpdatePostDateStruct date: 2024-03-04, sponsorCollaboratorsModule leadSponsor name: IRCCS San Raffaele, class: OTHER, collaborators name: Università Vita-Salute San Raffaele, descriptionModule briefSummary: The goal of this multicenter prospective and prevalence observational study is to punctually investigate and describe prevalence, predictors, quality of life and costs of Urinary Incontinence (UI) among female patients, female caregivers and female personnel in four hospitals in Northern Italy: San Raffaele hospital in Milan, San Raffaele Turro hospital in Milan, Zingonia Policlinico San Marco (BG) and Policlinico San Pietro in Ponte San Pietro (BG)., conditionsModule conditions: Female Urinary Incontinence, designModule studyType: OBSERVATIONAL, designInfo observationalModel: OTHER, timePerspective: PROSPECTIVE, enrollmentInfo count: 1842, type: ESTIMATED, armsInterventionsModule interventions name: No intervention, outcomesModule primaryOutcomes measure: Prevalence of middle-aged women with urinary incontinence, secondaryOutcomes measure: Predictors of urinary incontinence in middle-aged women, secondaryOutcomes measure: Quality of life of middle-aged women with urinary incontinence, secondaryOutcomes measure: Social impact of middle-aged women with urinary incontinence, secondaryOutcomes measure: Costs of urinary incontinence for middle-aged women, eligibilityModule sex: FEMALE, minimumAge: 40 Years, maximumAge: 65 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Policlinico San Marco Zingonia, city: Osio Sotto, state: Bergamo, zip: 24040, country: Italy, contacts name: Elisabetta Bagnato, role: CONTACT, email: [email protected], contacts name: Giulia Villa, role: CONTACT, phone: 0291751779, email: [email protected], geoPoint lat: 45.61608, lon: 9.58905, locations facility: Policlinico San Pietro Ponte San Pietro, city: Bergamo, zip: 24036, country: Italy, contacts name: Elisabetta Bagnato, role: CONTACT, email: [email protected], contacts name: Giulia Villa, role: CONTACT, phone: 0291751779, email: [email protected], geoPoint lat: 45.69601, lon: 9.66721, locations facility: San Raffaele Turro Hospital (MI), city: Milan, zip: 20127, country: Italy, geoPoint lat: 45.46427, lon: 9.18951, locations facility: San Raffaele Hospital (MI), city: Milan, zip: 20132, country: Italy, contacts name: Sara Trapani, role: CONTACT, phone: +39 3389879403, email: [email protected], contacts name: Giulia Villa, role: CONTACT, phone: 0291751779, email: [email protected], contacts name: Stefania Rinaldi, role: SUB_INVESTIGATOR, contacts name: Caglioni Martina, role: SUB_INVESTIGATOR, geoPoint lat: 45.46427, lon: 9.18951, documentSection largeDocumentModule largeDocs typeAbbrev: Prot, hasProtocol: True, hasSap: False, hasIcf: False, label: Study Protocol, date: 2023-08-23, uploadDate: 2024-02-15T07:26, filename: Prot_000.pdf, size: 544090, hasResults: False |
protocolSection identificationModule nctId: NCT06291428, orgStudyIdInfo id: F-CNIC-2024-007, briefTitle: Raman Spectroscopy Compared to Flow Cytometry, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-10-15, primaryCompletionDateStruct date: 2026-12-30, completionDateStruct date: 2026-12-30, studyFirstPostDateStruct date: 2024-03-04, lastUpdatePostDateStruct date: 2024-03-04, sponsorCollaboratorsModule leadSponsor name: Hospital Regional de Alta Especialidad del Bajio, class: OTHER, collaborators name: Optics research center, descriptionModule briefSummary: The detection of MRD is associated with an increased risk of relapse and adverse prognosis in all patient groups diagnosed with acute lymphoblastic leukemia (ALL). However, it has a sensitivity level that detects one leukemic cell in 10,000 normal cells, along with other disadvantages such as the need for a panel of fluorescent antibodies for MRD detection, and its measurement is not standardized in many centers. New determination techniques may be necessary for MRD evaluation. Raman spectroscopy is proposed as a potential technique for MRD measurement, which is based on the inelastic scattering of light that occurs when it interacts with matter, causing optical scattering, where a portion of the radiation changes its wavelength (by Raman effect).Objectives:MAIN OBJECTIVE:To evaluate the presence of MRD in patients with ALL by comparing a standard evaluation method using flow cytometry with a new proposed method using Raman spectroscopy.SPECIFIC OBJECTIVES:* To assess the presence of MRD using flow cytometry in patients with ALL.* To assess the presence of MRD using Raman spectroscopy in patients with ALL.* To perform a comparison between the MRD measurement techniques by determining sensitivity, specificity, positive predictive value, and negative predictive value.* To establish the validation of using Raman spectroscopy as a method for MRD evaluation.Study Design:An observational, cross-sectional, comparative, and diagnostic test study will be conducted on bone marrow aspirate samples from adult and pediatric ALL patients to evaluate the presence of MRD using Raman spectroscopy, comparing the results of this technique with those obtained using flow cytometry. As a diagnostic test study, sensitivity, specificity, positive predictive value, and negative predictive value will be evaluated. The study will be conducted on adult and pediatric patients diagnosed with acute lymphoblastic leukemia treated at the hemato-oncology department of the UMAE No. 1 National Medical Center Bajio and the UMAE Hospital Gynecology-Pediatrics No. 48.Inclusion Criteria:Patients diagnosed with ALL for whom MRD determination is clinically necessary will be included in the study. Their results will be evaluated using the gold standard, flow cytometry, and compared with results obtained through Raman spectroscopy., conditionsModule conditions: Acute Lymphoblastic Leukemia, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 50, type: ESTIMATED, armsInterventionsModule interventions name: Raman spectroscopy, outcomesModule primaryOutcomes measure: measurable residual disease, eligibilityModule sex: ALL, minimumAge: 2 Years, maximumAge: 70 Years, stdAges: CHILD, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False |
protocolSection identificationModule nctId: NCT06291415, orgStudyIdInfo id: 2022-523-GLOB1, briefTitle: The Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of HMPL-523 in Adult Subjects With Immune Thrombocytopenia (ITP), statusModule overallStatus: RECRUITING, startDateStruct date: 2024-04-02, primaryCompletionDateStruct date: 2026-04, completionDateStruct date: 2026-11, studyFirstPostDateStruct date: 2024-03-04, lastUpdatePostDateStruct date: 2024-04-19, sponsorCollaboratorsModule leadSponsor name: Hutchmed, class: INDUSTRY, descriptionModule briefSummary: This is an open-label, multicenter study to evaluate the safety, tolerability, and efficacy of HMPL-523 in adult subjects with ITP., conditionsModule conditions: Immune Thrombocytopenia, conditions: Blood Platelet Disorder, conditions: Hematologic Diseases, conditions: Purpura, Thrombocytopenic, conditions: Purpura, conditions: Blood Coagulation Disorder, conditions: Thrombotic Microangiopathies, conditions: Hemorrhagic Disorders, conditions: Autoimmune Diseases, conditions: Immune System Diseases, conditions: Hemorrhage, conditions: Pathologic Processes, conditions: Skin Manifestations, conditions: Thrombocytopenia, conditions: Purpura, Thrombocytopenic, Idiopathic, conditions: Primary Immune Thrombocytopenia, conditions: ITP - Immune Thrombocytopenia, designModule studyType: INTERVENTIONAL, phases: PHASE1, designInfo allocation: NON_RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: Part 1: Dose escalation stage - subjects will receive one of 3 dose levels of HMPL-523 to determine the recommended dose of HMPL-523 for the randomized dose optimization- stage (Part 2)Part 2: subjects will be randomized in a 1:1 ratio between the 2 dose levels recommended by the SRC to better understand the exposure/efficacy/toxicity relationship. At the end of Part 2, the SRC will evaluate the safety, tolerability, preliminary efficacy, and PK data to determine the Recommended Phase 3 dose (RP3D) of HMPL-523., primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 48, type: ESTIMATED, armsInterventionsModule interventions name: HMPL-523, outcomesModule primaryOutcomes measure: Safety and tolerability of HMPL-523 in adult subjects with primary ITP, primaryOutcomes measure: Dose Limiting Toxicities, secondaryOutcomes measure: Cmax (maximum plasma drug concentration), secondaryOutcomes measure: AUCtau (area under the concentration-time curve over a dosage interval), secondaryOutcomes measure: Tmax (time to reach maximum plasma drug concentration), secondaryOutcomes measure: Cmin (minimum plasma drug concentration), eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Center for Cancer and Blood Disorders, status: RECRUITING, city: Bethesda, state: Maryland, zip: 20817, country: United States, contacts name: Ralph V Boccia, MD, role: CONTACT, contacts name: Ralph V Boccia, MD, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 38.98067, lon: -77.10026, locations facility: Massachusetts General Hospital, status: NOT_YET_RECRUITING, city: Boston, state: Massachusetts, zip: 02114, country: United States, contacts name: David J Kuter, MD, role: CONTACT, contacts name: David J Kuter, MD, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 42.35843, lon: -71.05977, locations facility: Taussig Cancer Institute, status: NOT_YET_RECRUITING, city: Cleveland, state: Ohio, zip: 44106, country: United States, contacts name: Alan Lichtin, MD, role: CONTACT, contacts name: Alan Lichtin, MD, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 41.4995, lon: -81.69541, locations facility: Peninsula Private Hospital, status: NOT_YET_RECRUITING, city: Frankston, state: Victoria, country: Australia, contacts name: Huy Tran, MD, role: CONTACT, contacts name: Huy Tran, MD, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -38.14458, lon: 145.12291, locations facility: The Perth Blood Institute (PBI) Hollywood Specialist Centre, status: NOT_YET_RECRUITING, city: West Perth, state: Western Australia, country: Australia, contacts name: Ross Baker, MD, role: CONTACT, contacts name: Ross Baker, MD, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -31.94896, lon: 115.84199, locations facility: Marien Hospital Dusseldorf, status: NOT_YET_RECRUITING, city: Düsseldorf, zip: 40479, country: Germany, contacts name: Stefanie Groepper, MD, role: CONTACT, contacts name: Stefanie Groepper, MD, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 51.22172, lon: 6.77616, locations facility: Sykehuset Ostfold Kalnes (fosta) / Osfold Hospital Trust (MSL), status: NOT_YET_RECRUITING, city: Grålum, zip: 1714, country: Norway, contacts name: Waleed Ghanima, MD, role: CONTACT, contacts name: Waleed Ghanima, MD, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 59.29048, lon: 11.06668, locations facility: Hospital del Mar Barcelona, status: NOT_YET_RECRUITING, city: Barcelona, zip: 08003, country: Spain, contacts name: Blanca Gonzalez, MD, role: CONTACT, contacts name: Blanca Gonzalez, MD, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 41.38879, lon: 2.15899, locations facility: Hospital Universitari Vall d'Hebron, status: NOT_YET_RECRUITING, city: Barcelona, country: Spain, contacts name: David Ferreiras, MD, role: CONTACT, contacts name: David Ferreiras, MD, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 41.38879, lon: 2.15899, locations facility: University de Burgos, status: NOT_YET_RECRUITING, city: Burgos, zip: 09001, country: Spain, contacts name: Jose Gonzalez Lopez, MD, role: CONTACT, contacts name: Jose Gonzalez Lopez, MD, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 42.34106, lon: -3.70184, locations facility: Hospital Gregorio Maranon Madrid, status: NOT_YET_RECRUITING, city: Madrid, zip: 28007, country: Spain, contacts name: Cristina Izquierdo, MD, role: CONTACT, contacts name: Cristina Izquierdo, MD, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 40.4165, lon: -3.70256, locations facility: Clinica Universidad de Navarra, status: NOT_YET_RECRUITING, city: Madrid, zip: 28027, country: Spain, contacts name: Carlos Garcia Grande, MD, role: CONTACT, contacts name: Carlos Garcia Grande, MD, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 40.4165, lon: -3.70256, locations facility: Hospital Infanta Leonor, status: NOT_YET_RECRUITING, city: Madrid, zip: 28031, country: Spain, contacts name: Angeles Foncillas, MD, role: CONTACT, contacts name: Angeles Foncillas, MD, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 40.4165, lon: -3.70256, locations facility: Fundacion Jimenez Diaz, status: NOT_YET_RECRUITING, city: Madrid, zip: 28040, country: Spain, contacts name: Pilar Llamas Sillero, MD, role: CONTACT, contacts name: Pilar Llamas Sillero, MD, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 40.4165, lon: -3.70256, locations facility: Hospital Morales Meseguer, status: NOT_YET_RECRUITING, city: Murcia, zip: 30008, country: Spain, contacts name: Maria Lozano, MD, role: CONTACT, contacts name: Maria Lozano, MD, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 37.98704, lon: -1.13004, hasResults: False |
protocolSection identificationModule nctId: NCT06291402, orgStudyIdInfo id: RC 34-1-2024, briefTitle: Nasal Packing Duration and Development of Pharyngitis After Septorhinoplasty Surgery, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-03-10, primaryCompletionDateStruct date: 2024-06-15, completionDateStruct date: 2024-06-15, studyFirstPostDateStruct date: 2024-03-04, lastUpdatePostDateStruct date: 2024-03-04, sponsorCollaboratorsModule leadSponsor name: Al-Azhar University, class: OTHER, collaborators name: Benha University, descriptionModule briefSummary: Septoplasty or septal reconstruction is a corrective surgical procedure performed to straighten the nasal septum. It may be associated with numerous complications. To minimize these complications, both nasal cavities are frequently packed with different types of nasal packing. In our study we will try to find relationship between duration of nasal packing and postrhinoplasty sore throat and pharyngitis., conditionsModule conditions: Rhinitis, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 100, type: ESTIMATED, outcomesModule primaryOutcomes measure: Sore throat, secondaryOutcomes measure: Dysphagia, secondaryOutcomes measure: Throat irritation, eligibilityModule sex: ALL, minimumAge: 20 Years, maximumAge: 40 Years, stdAges: ADULT, contactsLocationsModule locations facility: Neveen Kohaf, city: Tanta, zip: 11865, country: Egypt, contacts name: Neveen Kohaf, Ph.D, role: CONTACT, phone: +201060383012, email: [email protected], contacts name: Haney Bauiomy, M.D, role: PRINCIPAL_INVESTIGATOR, contacts name: Ahmed Abosakaya, M.D, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 30.78847, lon: 31.00192, hasResults: False |
protocolSection identificationModule nctId: NCT06291389, orgStudyIdInfo id: RC.2.8.2023, briefTitle: Intraoperative Peak Airway Pressure Changes on Postoperative Pulmonary Function After Muscle Plication, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-03-10, primaryCompletionDateStruct date: 2024-05-15, completionDateStruct date: 2024-05-15, studyFirstPostDateStruct date: 2024-03-04, lastUpdatePostDateStruct date: 2024-03-04, sponsorCollaboratorsModule leadSponsor name: Al-Azhar University, class: OTHER, collaborators name: Benha University, descriptionModule briefSummary: An abdominal panniculus excision procedure is known as an abdominoplasty (panniculectomy). Musculofascial plication is a crucial aspect of abdominoplasty, especially for patients with significant divarication of the recti muscles. This study aimed to evaluate the effect of intraoperative changes in peak airway pressure (PAP) after muscle plication on postoperative pulmonary function., conditionsModule conditions: Abdominal Compartment Syndrome, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 120, type: ESTIMATED, outcomesModule primaryOutcomes measure: Intraoperative peak airway pressure (PAP), secondaryOutcomes measure: Duration of oxygen therapy, secondaryOutcomes measure: Post operative Tidal Volume (Vt) (Measured by spirometer), secondaryOutcomes measure: Post operative Respiratory Rate (RR), secondaryOutcomes measure: Hospital stay., eligibilityModule sex: ALL, minimumAge: 20 Years, maximumAge: 50 Years, stdAges: ADULT, contactsLocationsModule locations facility: Neveen Kohaf, city: Tanta, zip: 11865, country: Egypt, contacts name: Haney Bauiomy, role: PRINCIPAL_INVESTIGATOR, contacts name: Ahmed Abosakaya, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 30.78847, lon: 31.00192, hasResults: False |
protocolSection identificationModule nctId: NCT06291376, orgStudyIdInfo id: D928FC00001, briefTitle: Study of Ravulizumab in Immunoglobulin A Nephropathy (IgAN), acronym: ICAN, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-03-29, primaryCompletionDateStruct date: 2026-02-23, completionDateStruct date: 2029-10-25, studyFirstPostDateStruct date: 2024-03-04, lastUpdatePostDateStruct date: 2024-04-29, sponsorCollaboratorsModule leadSponsor name: Alexion Pharmaceuticals, Inc., class: INDUSTRY, descriptionModule briefSummary: The primary objective of this study to evaluate the efficacy of ravulizumab compared with placebo to reduce proteinuria and slow the rate of eGFR decline in adult participants with IgAN who are at risk of disease progression., conditionsModule conditions: Immunoglobulin A Nephropathy, conditions: IgAN, designModule studyType: INTERVENTIONAL, phases: PHASE3, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: QUADRUPLE, whoMasked: PARTICIPANT, whoMasked: CARE_PROVIDER, whoMasked: INVESTIGATOR, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 470, type: ESTIMATED, armsInterventionsModule interventions name: Ravulizumab, interventions name: Placebo, outcomesModule primaryOutcomes measure: Change from Baseline in Proteinuria Based on 24-hour Urine Protein Creatinine Ratio (UPCR) at Week 34, primaryOutcomes measure: Glomerular Filtration Rate (eGFR) Over 106 Weeks, secondaryOutcomes measure: Change from Baseline in Proteinuria Based on 24-hour Urine Protein Creatinine Ratio (UPCR) at Weeks 10, 26, 34, 50, and 106, secondaryOutcomes measure: Change From Baseline in eGFR at Weeks 34, 50, and 106, secondaryOutcomes measure: Change From Baseline in Albuminuria Based on Urine Albumin to Creatinine Ratio (UACR) at Weeks 10, 26, 34, 50, and 106, secondaryOutcomes measure: Reduction in 24-hour UPCR ≥ 50% From Baseline to Weeks 10, 26, 34, 50, and 106, secondaryOutcomes measure: Number of Participants With Partial Remission at Weeks 34, 50, and 106, secondaryOutcomes measure: Change from Baseline in Functional Assessment of Chronic Illness Therapy (FACIT)-Fatigue at Weeks 34, 50, and 106, secondaryOutcomes measure: Number of Participants With Composite Kidney Failure Endpoint, secondaryOutcomes measure: Reduction in 24-hour UPCR ≥ 50% From Baseline at both Weeks 34 and 106, secondaryOutcomes measure: Number of Participants With Kidney Hierarchical Composite Endpoint, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Research Site, status: NOT_YET_RECRUITING, city: Alabaster, state: Alabama, zip: 35007, country: United States, geoPoint lat: 33.24428, lon: -86.81638, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Phoenix, state: Arizona, zip: 85054, country: United States, geoPoint lat: 33.44838, lon: -112.07404, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Loma Linda, state: California, zip: 92354, country: United States, geoPoint lat: 34.04835, lon: -117.26115, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Los Angeles, state: California, zip: 90022, country: United States, geoPoint lat: 34.05223, lon: -118.24368, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Los Angeles, state: California, zip: 90027, country: United States, geoPoint lat: 34.05223, lon: -118.24368, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Los Angeles, state: California, zip: 90095, country: United States, geoPoint lat: 34.05223, lon: -118.24368, locations facility: Research Site, status: NOT_YET_RECRUITING, city: San Francisco, state: California, zip: 94143, country: United States, geoPoint lat: 37.77493, lon: -122.41942, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Stanford, state: California, zip: 94305, country: United States, geoPoint lat: 37.42411, lon: -122.16608, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Torrance, state: California, zip: 90502, country: United States, geoPoint lat: 33.83585, lon: -118.34063, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Aurora, state: Colorado, zip: 80045, country: United States, geoPoint lat: 39.72943, lon: -104.83192, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Bay Pines, state: Florida, zip: 33744, country: United States, geoPoint lat: 27.81419, lon: -82.77816, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Miami, state: Florida, zip: 33136, country: United States, geoPoint lat: 25.77427, lon: -80.19366, locations facility: Research Site, status: RECRUITING, city: Orlando, state: Florida, zip: 32806, country: United States, geoPoint lat: 28.53834, lon: -81.37924, locations facility: Research Site, status: RECRUITING, city: Acworth, state: Georgia, zip: 30101, country: United States, geoPoint lat: 34.06635, lon: -84.67837, locations facility: Research Site, status: RECRUITING, city: Lawrenceville, state: Georgia, zip: 30046, country: United States, geoPoint lat: 33.95621, lon: -83.98796, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Augusta, state: Maine, zip: 04330, country: United States, geoPoint lat: 44.31062, lon: -69.77949, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Boston, state: Massachusetts, zip: 02111, country: United States, geoPoint lat: 42.35843, lon: -71.05977, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Boston, state: Massachusetts, zip: 02114, country: United States, geoPoint lat: 42.35843, lon: -71.05977, locations facility: Research Site, status: RECRUITING, city: Pontiac, state: Michigan, zip: 48341, country: United States, geoPoint lat: 42.63892, lon: -83.29105, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Minneapolis, state: Minnesota, zip: 55435, country: United States, geoPoint lat: 44.97997, lon: -93.26384, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Minneapolis, state: Minnesota, zip: 55455, country: United States, geoPoint lat: 44.97997, lon: -93.26384, locations facility: Research Site, status: RECRUITING, city: Saint Peters, state: Missouri, zip: 63376, country: United States, geoPoint lat: 38.80033, lon: -90.62651, locations facility: Research Site, status: NOT_YET_RECRUITING, city: North Las Vegas, state: Nevada, zip: 89086, country: United States, geoPoint lat: 36.19886, lon: -115.1175, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Albany, state: New York, zip: 12208, country: United States, geoPoint lat: 42.65258, lon: -73.75623, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Bronx, state: New York, zip: 10468, country: United States, geoPoint lat: 40.84985, lon: -73.86641, locations facility: Research Site, status: NOT_YET_RECRUITING, city: East Setauket, state: New York, zip: 11733, country: United States, geoPoint lat: 40.94149, lon: -73.10594, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Charleston, state: South Carolina, zip: 29425, country: United States, geoPoint lat: 32.77657, lon: -79.93092, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Arlington, state: Texas, zip: 76002, country: United States, geoPoint lat: 32.73569, lon: -97.10807, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Houston, state: Texas, zip: 77054, country: United States, geoPoint lat: 29.76328, lon: -95.36327, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Shenandoah, state: Texas, zip: 77384, country: United States, geoPoint lat: 30.18022, lon: -95.45577, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Charlottesville, state: Virginia, zip: 22903, country: United States, geoPoint lat: 38.02931, lon: -78.47668, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Milwaukee, state: Wisconsin, zip: 53226, country: United States, geoPoint lat: 43.0389, lon: -87.90647, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Ciudad Autonoma Bs As, zip: C1015ABO, country: Argentina, geoPoint lat: -34.61315, lon: -58.37723, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Córdoba, zip: X5016LIG, country: Argentina, geoPoint lat: -31.4135, lon: -64.18105, locations facility: Research Site, status: NOT_YET_RECRUITING, city: La Plata, zip: B1902COS, country: Argentina, geoPoint lat: -34.92145, lon: -57.95453, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Rosario, zip: 2000, country: Argentina, geoPoint lat: -32.94682, lon: -60.63932, locations facility: Research Site, status: WITHDRAWN, city: San Luis, zip: D5700, country: Argentina, geoPoint lat: -33.29501, lon: -66.33563, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Canberra, zip: 2605, country: Australia, geoPoint lat: -35.28346, lon: 149.12807, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Clayton, zip: 3168, country: Australia, geoPoint lat: -37.91667, lon: 145.11667, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Concord, zip: 2139, country: Australia, geoPoint lat: -33.84722, lon: 151.10381, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Herston, zip: 4029, country: Australia, geoPoint lat: -27.44453, lon: 153.01852, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Liverpool, zip: 2170, country: Australia, geoPoint lat: -33.90011, lon: 150.93328, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Southport, zip: 4222, country: Australia, geoPoint lat: -27.96724, lon: 153.39796, locations facility: Research Site, status: NOT_YET_RECRUITING, city: St Albans, zip: 3021, country: Australia, geoPoint lat: -37.73901, lon: 144.80024, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Graz, zip: 8036, country: Austria, geoPoint lat: 47.06667, lon: 15.45, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Innsbruck, zip: 6020, country: Austria, geoPoint lat: 47.26266, lon: 11.39454, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Linz, zip: 4020, country: Austria, geoPoint lat: 48.30639, lon: 14.28611, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Brussels, zip: 1090, country: Belgium, geoPoint lat: 50.85045, lon: 4.34878, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Edegem, zip: 2650, country: Belgium, geoPoint lat: 51.15662, lon: 4.44504, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Leuven, zip: 3000, country: Belgium, geoPoint lat: 50.87959, lon: 4.70093, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Liège, zip: 4000, country: Belgium, geoPoint lat: 50.63373, lon: 5.56749, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Roeselare, zip: 8800, country: Belgium, geoPoint lat: 50.94653, lon: 3.12269, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Belo Horizonte, zip: 30130-100, country: Brazil, geoPoint lat: -19.92083, lon: -43.93778, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Belo Horizonte, zip: 30150-221, country: Brazil, geoPoint lat: -19.92083, lon: -43.93778, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Botucatu, zip: 18618-687, country: Brazil, geoPoint lat: -22.88583, lon: -48.445, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Curitiba, zip: 80440-020, country: Brazil, geoPoint lat: -25.42778, lon: -49.27306, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Fortaleza, zip: 60430-270, country: Brazil, geoPoint lat: -3.71722, lon: -38.54306, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Recife, zip: 50670-901, country: Brazil, geoPoint lat: -8.05389, lon: -34.88111, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Ribeirão Preto, zip: 14051-140, country: Brazil, geoPoint lat: -21.1775, lon: -47.81028, locations facility: Research Site, status: NOT_YET_RECRUITING, city: S.J. Do Rio Preto, zip: 15090-000, country: Brazil, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Salvador, zip: 40170-130, country: Brazil, geoPoint lat: -12.97111, lon: -38.51083, locations facility: Research Site, status: NOT_YET_RECRUITING, city: São Paulo, zip: 04038-002, country: Brazil, geoPoint lat: -23.5475, lon: -46.63611, locations facility: Research Site, status: NOT_YET_RECRUITING, city: São Paulo, zip: 05403-000, country: Brazil, geoPoint lat: -23.5475, lon: -46.63611, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Winnipeg, state: Manitoba, zip: R2V 3M3, country: Canada, geoPoint lat: 49.8844, lon: -97.14704, locations facility: Research Site, status: NOT_YET_RECRUITING, city: London, state: Ontario, zip: N6A 5W9, country: Canada, geoPoint lat: 42.98339, lon: -81.23304, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Araucania, zip: 4781151, country: Chile, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Providencia, zip: 7500000, country: Chile, geoPoint lat: -33.43107, lon: -70.60454, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Santiago, zip: 7500922, country: Chile, geoPoint lat: -33.45694, lon: -70.64827, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Santiago, zip: 8330044, country: Chile, geoPoint lat: -33.45694, lon: -70.64827, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Valdivia, zip: 4070022, country: Chile, geoPoint lat: -39.81422, lon: -73.24589, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Baotou, zip: 14010, country: China, geoPoint lat: 40.65222, lon: 109.82222, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Beijing, zip: 100029, country: China, geoPoint lat: 39.9075, lon: 116.39723, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Beijing, zip: 100034, country: China, geoPoint lat: 39.9075, lon: 116.39723, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Beijing, zip: 100044, country: China, geoPoint lat: 39.9075, lon: 116.39723, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Changsha, zip: 410013, country: China, geoPoint lat: 28.19874, lon: 112.97087, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Chengdu, zip: 610000, country: China, geoPoint lat: 30.66667, lon: 104.06667, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Chengdu, zip: 610072, country: China, geoPoint lat: 30.66667, lon: 104.06667, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Chongqing, zip: 400010, country: China, geoPoint lat: 29.56278, lon: 106.55278, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Guangzhou, zip: 510080, country: China, geoPoint lat: 23.11667, lon: 113.25, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Guangzhou, zip: 510100, country: China, geoPoint lat: 23.11667, lon: 113.25, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Guangzhou, zip: 510280, country: China, geoPoint lat: 23.11667, lon: 113.25, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Hangzhou, zip: 310003, country: China, geoPoint lat: 30.29365, lon: 120.16142, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Hangzhou, zip: 310009, country: China, geoPoint lat: 30.29365, lon: 120.16142, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Jinan, zip: 250012, country: China, geoPoint lat: 36.66833, lon: 116.99722, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Jinan, zip: 250021, country: China, geoPoint lat: 36.66833, lon: 116.99722, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Jinhua, country: China, geoPoint lat: 29.10678, lon: 119.64421, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Lanzhou, zip: 730000, country: China, geoPoint lat: 36.05701, lon: 103.83987, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Luoyang, zip: 471000, country: China, geoPoint lat: 34.68361, lon: 112.45361, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Nanchang, zip: 330006, country: China, geoPoint lat: 28.68396, lon: 115.85306, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Nanchang, zip: 330008, country: China, geoPoint lat: 28.68396, lon: 115.85306, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Nanjing, zip: 210009, country: China, geoPoint lat: 32.06167, lon: 118.77778, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Nanjing, zip: 210011, country: China, geoPoint lat: 32.06167, lon: 118.77778, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Nanjing, zip: 210029, country: China, geoPoint lat: 32.06167, lon: 118.77778, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Ningbo, zip: 315010, country: China, geoPoint lat: 29.87819, lon: 121.54945, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Qingdao, zip: 110016, country: China, geoPoint lat: 36.06488, lon: 120.38042, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Shanghai, zip: 200025, country: China, geoPoint lat: 31.22222, lon: 121.45806, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Shanghai, zip: 200040, country: China, geoPoint lat: 31.22222, lon: 121.45806, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Shanghai, zip: 200065, country: China, geoPoint lat: 31.22222, lon: 121.45806, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Shenyang, zip: 110001, country: China, geoPoint lat: 41.79222, lon: 123.43278, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Shenzhen, zip: 518036, country: China, geoPoint lat: 22.54554, lon: 114.0683, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Shenzhen, zip: 518053, country: China, geoPoint lat: 22.54554, lon: 114.0683, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Urumqi, zip: 831118, country: China, geoPoint lat: 43.80096, lon: 87.60046, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Wuhan, zip: 430060, country: China, geoPoint lat: 30.58333, lon: 114.26667, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Wuxi, zip: 214023, country: China, geoPoint lat: 31.56887, lon: 120.28857, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Xian, zip: 710061, country: China, geoPoint lat: 34.25833, lon: 108.92861, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Yantai, zip: 264000, country: China, geoPoint lat: 37.47649, lon: 121.44081, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Yibin, zip: 610500, country: China, geoPoint lat: 28.76667, lon: 104.62383, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Yinchuan, zip: 750004, country: China, geoPoint lat: 38.46806, lon: 106.27306, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Zhanjiang, zip: 524001, country: China, geoPoint lat: 21.28145, lon: 110.34271, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Zhengzhou, country: China, geoPoint lat: 34.75778, lon: 113.64861, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Barranquilla, zip: 080020, country: Colombia, geoPoint lat: 10.96854, lon: -74.78132, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Bogota, zip: 111411, country: Colombia, geoPoint lat: 4.60971, lon: -74.08175, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Cali, zip: 760032, country: Colombia, geoPoint lat: 3.43722, lon: -76.5225, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Rionegro, zip: 054047, country: Colombia, geoPoint lat: 6.15515, lon: -75.37371, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Nový Jičín, zip: 741 01, country: Czechia, geoPoint lat: 49.59438, lon: 18.01028, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Praha 2, zip: 128 00, country: Czechia, geoPoint lat: 50.08804, lon: 14.42076, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Praha 4, zip: 140 00, country: Czechia, geoPoint lat: 50.08804, lon: 14.42076, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Amiens Cedex 1, zip: 80054, country: France, geoPoint lat: 49.9, lon: 2.3, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Bayonne, zip: 64100, country: France, geoPoint lat: 43.48333, lon: -1.48333, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Brest Cedex, zip: 29200, country: France, geoPoint lat: 48.3903, lon: -4.48628, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Chambéry Cedex, zip: 73011, country: France, geoPoint lat: 45.56667, lon: 5.93333, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Clermont Ferrand, zip: 63003, country: France, geoPoint lat: 45.77966, lon: 3.08628, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Le Kremlin-Bicêtre, zip: 94270, country: France, geoPoint lat: 48.81471, lon: 2.36073, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Marseille, zip: 13385, country: France, geoPoint lat: 43.29551, lon: 5.38958, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Nantes, zip: 44093, country: France, geoPoint lat: 47.21725, lon: -1.55336, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Nice cedex 1, zip: 06002, country: France, geoPoint lat: 43.70313, lon: 7.26608, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Paris, zip: 75015, country: France, geoPoint lat: 48.85341, lon: 2.3488, locations facility: Research Site, status: 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country: Italy, geoPoint lat: 37.31065, lon: 13.57661, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Bari, zip: 70124, country: Italy, geoPoint lat: 41.11148, lon: 16.8554, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Bologna, zip: 40138, country: Italy, geoPoint lat: 44.49381, lon: 11.33875, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Brescia, zip: 25123, country: Italy, geoPoint lat: 45.53558, lon: 10.21472, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Cagliari, zip: 09121, country: Italy, geoPoint lat: 39.23054, lon: 9.11917, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Firenze, zip: 50134, country: Italy, geoPoint lat: 43.77925, lon: 11.24626, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Milano, zip: 20122, country: Italy, geoPoint lat: 45.46427, lon: 9.18951, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Milano, zip: 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59100, country: Malaysia, geoPoint lat: 3.1412, lon: 101.68653, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Seremban, zip: 70300, country: Malaysia, geoPoint lat: 2.7297, lon: 101.9381, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Taiping, zip: 34000, country: Malaysia, geoPoint lat: 4.85, lon: 100.73333, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Chihuahua, zip: 31000, country: Mexico, geoPoint lat: 28.63528, lon: -106.08889, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Culiacan, zip: 80020, country: Mexico, geoPoint lat: 24.79032, lon: -107.38782, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Guadalajara, zip: 44280, country: Mexico, geoPoint lat: 20.66682, lon: -103.39182, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Juriquilla, zip: 76320, country: Mexico, geoPoint lat: 20.71277, lon: -100.45568, locations facility: Research Site, status: 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Turkey, geoPoint lat: 37.87135, lon: 32.48464, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Cambridge, zip: CB2 0QQ, country: United Kingdom, geoPoint lat: 52.2, lon: 0.11667, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Doncaster, zip: DN2 5LT, country: United Kingdom, geoPoint lat: 53.52285, lon: -1.13116, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Leicester, zip: Le5 4PW, country: United Kingdom, geoPoint lat: 52.6386, lon: -1.13169, locations facility: Research Site, status: NOT_YET_RECRUITING, city: London, zip: E1 1BB, country: United Kingdom, geoPoint lat: 51.50853, lon: -0.12574, locations facility: Research Site, status: NOT_YET_RECRUITING, city: London, zip: SE1 9RT, country: United Kingdom, geoPoint lat: 51.50853, lon: -0.12574, locations facility: Research Site, status: NOT_YET_RECRUITING, city: London, zip: SE5 9NU, country: United Kingdom, geoPoint lat: 51.50853, lon: -0.12574, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Salford, zip: M6 8HD, country: United Kingdom, geoPoint lat: 53.48771, lon: -2.29042, hasResults: False |
protocolSection identificationModule nctId: NCT06291363, orgStudyIdInfo id: 2024-3612, briefTitle: Impact of Administration of Esmolol on Nociception Level-guided Control of Nociception., acronym: ESMONOL, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04-04, primaryCompletionDateStruct date: 2025-03-03, completionDateStruct date: 2025-03-04, studyFirstPostDateStruct date: 2024-03-04, lastUpdatePostDateStruct date: 2024-03-25, sponsorCollaboratorsModule leadSponsor name: Ciusss de L'Est de l'Île de Montréal, class: OTHER, descriptionModule briefSummary: This study aims to evaluate esmolol's perfusion impact during induction and maintenance of general anesthesia, using Nociception-Level-guided control of nociception, in adult patients undergoing laparoscopic and lower abdominal surgery, on intraoperative remifentanil consumption and postoperative pain in the Post-Anesthesia Care Unit., conditionsModule conditions: Opioid Use, Unspecified, conditions: Anesthesia, conditions: Nociceptive Pain, designModule studyType: INTERVENTIONAL, phases: PHASE4, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: Two groups of patients randomized into Group "ESMOLOL" for esmolol and group "Standard of Care" for a total of 64 participants., primaryPurpose: TREATMENT, maskingInfo masking: QUADRUPLE, maskingDescription: Randomization will be done prior to the entrance in the OR, the day of the surgery., whoMasked: PARTICIPANT, whoMasked: CARE_PROVIDER, whoMasked: INVESTIGATOR, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 64, type: ESTIMATED, armsInterventionsModule interventions name: Esmolol Hydrochloride, interventions name: Saline, outcomesModule primaryOutcomes measure: Intra operative remifentanil administration, secondaryOutcomes measure: The NOL Index variation before and after orotracheal intubation and first surgical incision, secondaryOutcomes measure: The mean intraoperative blood pressure and heart rate, secondaryOutcomes measure: doses and time weighted of norepinephrine (mg); ephedrine (mg), glycopyrrolate (mg) and atropine (mg), secondaryOutcomes measure: Total time with NOL value above > 25, secondaryOutcomes measure: The total time and time weighted average of hypotension and/or bradycardia, secondaryOutcomes measure: The time to first analgesic requirement in PACU, secondaryOutcomes measure: The amount of morphine equivalent consumption, secondaryOutcomes measure: The intensity of pain at rest and under stress, secondaryOutcomes measure: Postoperative nausea and vomiting (PONV) and antiemetics use, secondaryOutcomes measure: The time spent in PACU, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 65 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Maisonneuve-Rosemont Hospital - CIUSSS de l'Est de l'Île de Montréal, city: Montréal-Est, state: Quebec, zip: H1T2M4, country: Canada, contacts name: Pascal Laferrière-Langois, MD FRQS, role: CONTACT, phone: +1-819-432-5847, email: [email protected], contacts name: Pascal Laferrière-Langois, MD FRQS, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 45.63202, lon: -73.5075, documentSection largeDocumentModule largeDocs typeAbbrev: Prot, hasProtocol: True, hasSap: False, hasIcf: False, label: Study Protocol, date: 2024-02-26, uploadDate: 2024-03-21T17:38, filename: Prot_000.pdf, size: 732855, hasResults: False |
protocolSection identificationModule nctId: NCT06291350, orgStudyIdInfo id: 23-AOI-05, briefTitle: Peridontal and Intestinal Microbiota in Patients With Gingival Scarring Pemphigoid, acronym: MICROPC, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-03-15, primaryCompletionDateStruct date: 2026-03-15, completionDateStruct date: 2026-09-15, studyFirstPostDateStruct date: 2024-03-04, lastUpdatePostDateStruct date: 2024-03-15, sponsorCollaboratorsModule leadSponsor name: Centre Hospitalier Universitaire de Nice, class: OTHER, descriptionModule briefSummary: Patients suffering from Mucous Membrane Pemphigoid with desquamative gingivitis (MMPg) generally present a more degraded periodontal condition compared with controls. Bullous disease could represent a risk factor for plaque-induced periodontal disease, and vice versa.Indeed, the dysbiotic periodontal microbiota could aggravate the gingival damage specific to MMP, either directly by activating inflammatory pathways, or indirectly by degrading cellular and matrix components. On the other hand, areas of erosive gingiva generated by the autoimmune process could increase the virulent power of periodontal pathobionts, by representing accessible, nutrient-rich connective surfaces. Moreover, in recent years, bacterial studies based on a high-throughput metagenomic approach have suggested the existence of a relationship between the oral and intestinal microbiota in patients with degraded periodontal conditions and suffering from autoimmune inflammatory diseases (inflammatory bowel disease, acute graft-versus-host disease). This relationship can also be envisaged in MMPg patients who meet the conditions that allow this type of pathological process to occur: autoimmune disease; disruption of the gingival epithelial barrier in erosive gingival areas (increasing the risk of antigen exposure); large amounts of thick plaque; degraded periodontal condition with the presence of numerous periodontal pockets from which periodontopathogenic bacteria can translocate intra-tissularly and cause distant adverse consequences.The main aim of this observational, multicentre, case-control, matched study is to compare the composition of the periodontal microbiota between MMPg patients and control patients (arm 2 and arm 3). The secondary objectives are to compare the composition of periodontal and intestinal microbiota in cases and control patients (arm 2 and arm 3), to compare periodontal microbiota composition in cases and control patients (arm 2) according to periodontitis severity, and to compare gut microbiota composition between cases and control patients (arm 2 and arm3). To date, no such study exists., conditionsModule conditions: Pemphigoid, Benign Mucous Membrane, conditions: Gingivitis Hyperplastic, designModule studyType: OBSERVATIONAL, designInfo observationalModel: OTHER, timePerspective: PROSPECTIVE, enrollmentInfo count: 45, type: ESTIMATED, armsInterventionsModule interventions name: Plaque sampling and stool collection, interventions name: periodontal examination, outcomesModule primaryOutcomes measure: composition of the periodontal microbiota, secondaryOutcomes measure: Compare the composition (name and number of bacterial colonies) of periodontal in MMP and control patients (arm 2 and arm 3)., secondaryOutcomes measure: Compare the composition (name and number of bacterial colonies) intestinal microbiota in MMP and control patients (arm 2 and arm 3)., secondaryOutcomes measure: Compare (name and number of bacterial colonies) periodontal microbiota composition in MMP and control patients (arm 2) according to periodontitis severity (non-severe/severe), secondaryOutcomes measure: Compare (name and number of bacterial colonies) gut microbiota composition between MMP and control patients (arm 2 and arm3), eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Nice University Hospital, city: Nice, zip: 06000, country: France, contacts name: Sophie DRIDI, PUPH, role: CONTACT, phone: 04 92 03 30 07, email: [email protected], contacts name: Rachida Yatimi, role: CONTACT, phone: 04 92 03 30 07, email: [email protected], contacts name: Sophie DRIDI, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 43.70313, lon: 7.26608, locations facility: Paris hospital Pitié Salpetrière (APHP), city: Paris, zip: 75013, country: France, contacts name: Juliette ROCHEFORT, role: CONTACT, phone: 0142178416, email: [email protected], contacts name: Juliette ROCHEFORT, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 48.85341, lon: 2.3488, locations facility: Paris hospital Bretonneau (APHP), city: Paris, zip: 75018, country: France, contacts name: Anne-Laure AJEIL, role: CONTACT, phone: 0153111800, email: [email protected], contacts name: Anne-Laure AJEIL, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 48.85341, lon: 2.3488, hasResults: False |
protocolSection identificationModule nctId: NCT06291337, orgStudyIdInfo id: Pro2019001483, secondaryIdInfos id: 10-204Mc, type: OTHER, domain: Rutgers IRB, briefTitle: Ibuprofen Inhibits Human Sweet Taste, statusModule overallStatus: COMPLETED, startDateStruct date: 2020-06-01, primaryCompletionDateStruct date: 2023-09-01, completionDateStruct date: 2023-09-30, studyFirstPostDateStruct date: 2024-03-04, lastUpdatePostDateStruct date: 2024-03-04, sponsorCollaboratorsModule leadSponsor name: Rutgers, The State University of New Jersey, class: OTHER, collaborators name: Monell Chemical Senses Center, descriptionModule briefSummary: The sweet taste receptor, TAS1R2-TAS1R3, is expressed both orally, where it signals sweet taste, and extraorally in the intestine and pancreas, where it may affect glucose absorption and metabolism. Recently, ibuprofen and naproxen have been identified to inhibit human T1R3 when heterologously expressed in cells. In the present study, the initial objective was to determine if ibuprofen and naproxen inhibit interactions of sugars with human sweet taste receptor under normal, physiological conditions. Ten healthy participants were asked to rate sweetness intensity for a range of sweet stimuli (sucrose, fructose, sucralose) after a prerinse of ibuprofen, naproxen or water. Both ibuprofen and naproxen inhibited sweet taste intensity in a dose-dependent manner. In association studies, ibuprofen use has been linked to preserved metabolic function, as its use is correlated with lower rates of Alzheimer's disease, diabetes and colon cancer. Here the investigators present a potential novel pathway for systemic ibuprofen to impact these metabolic diseases., conditionsModule conditions: Treatment of Sweet Taste Receptors Without or With an Oral Rinse of Ibuprofen Solution in Healthy Participants, conditions: Treatment of Sweet Taste Receptors Without or With an Oral Rinse of Naproxen Solution in Healthy Participants, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NON_RANDOMIZED, interventionModel: CROSSOVER, interventionModelDescription: We are testing individual sin a within subject control for their sweet taste ratings of sugars without and with oral rinses of ibuprofen and naproxen., primaryPurpose: BASIC_SCIENCE, maskingInfo masking: NONE, enrollmentInfo count: 32, type: ACTUAL, armsInterventionsModule interventions name: Inhibition of Sweet Taste by Ibuprofen Oral Rinses, interventions name: Inhibition of Sweet Taste by Naproxen Oral Rinses, outcomesModule primaryOutcomes measure: Sweet taste ratings, primaryOutcomes measure: Sugar detection thresholds, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 70 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Food Science and Nutritional Sciences, city: New Brunswick, state: New Jersey, zip: 08901, country: United States, geoPoint lat: 40.48622, lon: -74.45182, hasResults: False |
protocolSection identificationModule nctId: NCT06291324, orgStudyIdInfo id: IRB00103472, secondaryIdInfos id: LCI-SUPP-CRF-WATD-001, type: OTHER, domain: Atrium Health, briefTitle: WATD and Cancer-Related Fatigue: A Study For Patients Undergoing Anti-Cancer Treatment, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-05, primaryCompletionDateStruct date: 2025-12-15, completionDateStruct date: 2025-12-15, studyFirstPostDateStruct date: 2024-03-04, lastUpdatePostDateStruct date: 2024-03-04, sponsorCollaboratorsModule leadSponsor name: Wake Forest University Health Sciences, class: OTHER, collaborators name: Atrium Health Levine Cancer Institute, descriptionModule briefSummary: The purpose of this study is to evaluate the feasibility of using a commercial WATD (Wearable Activity Tracker Device) to collect HRV (Heart Rate Variability) data from pancreatic and breast cancer patients., conditionsModule conditions: Pancreatic Cancer, conditions: Breast Cancer, designModule studyType: OBSERVATIONAL, designInfo observationalModel: CASE_ONLY, timePerspective: PROSPECTIVE, enrollmentInfo count: 46, type: ESTIMATED, outcomesModule primaryOutcomes measure: Adherence and acceptability, secondaryOutcomes measure: Theme, secondaryOutcomes measure: Heart rate variability (HRV), eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Levine Cancer Institute, city: Charlotte, state: North Carolina, zip: 28204, country: United States, contacts name: Alicia Patrick, role: CONTACT, phone: 980-292-1746, email: [email protected], contacts name: Dori Beeler, PhD, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 35.22709, lon: -80.84313, hasResults: False |
protocolSection identificationModule nctId: NCT06291311, orgStudyIdInfo id: MT_NIPP-HPV_ERBE, briefTitle: Non-Invasive Plasma Treatment for Cervical Infections: Targeting High- and Low-Risk HPV Variants, statusModule overallStatus: RECRUITING, startDateStruct date: 2023-12-27, primaryCompletionDateStruct date: 2024-06, completionDateStruct date: 2025-12, studyFirstPostDateStruct date: 2024-03-04, lastUpdatePostDateStruct date: 2024-03-04, sponsorCollaboratorsModule leadSponsor name: University Hospital Tuebingen, class: OTHER, descriptionModule briefSummary: This is a prospective, single-center, observational proof-of-principle clinical trial at the Department of Women's Health of the University Hospital Tübingen., conditionsModule conditions: HPV Infection, conditions: Cervical Cancer, designModule studyType: OBSERVATIONAL, designInfo observationalModel: CASE_CONTROL, timePerspective: PROSPECTIVE, enrollmentInfo count: 50, type: ESTIMATED, armsInterventionsModule interventions name: Cold physical Plasma, interventions name: Control group, outcomesModule primaryOutcomes measure: HPV eradication rate, secondaryOutcomes measure: Correlation of HPV Genotyping, secondaryOutcomes measure: HPV-Quality-of-Life (HPV-QoL), secondaryOutcomes measure: Tissue Tolerance and Compatibility of NIPP Treatment, secondaryOutcomes measure: Detection of Intracellular Molecular Plasma Mechanisms, eligibilityModule sex: FEMALE, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: University Hospital Tuebingen, Department of Women's Health, status: RECRUITING, city: Tuebingen, zip: 72076, country: Germany, contacts name: Martin Weiss, Dr. med., role: CONTACT, phone: +4970712982211, email: [email protected], geoPoint lat: 48.52266, lon: 9.05222, hasResults: False |
protocolSection identificationModule nctId: NCT06291298, orgStudyIdInfo id: STUDY006542, briefTitle: Novel Adaptive Cognitive Training in Autistic Adults With Co-occurring Insomnia, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-03-01, primaryCompletionDateStruct date: 2025-03-01, completionDateStruct date: 2025-04-01, studyFirstPostDateStruct date: 2024-03-04, lastUpdatePostDateStruct date: 2024-03-04, sponsorCollaboratorsModule leadSponsor name: University of South Florida, class: OTHER, descriptionModule briefSummary: The proposed study will test the usability and feasibility of a novel cognitive training (COGMUSE) for autistic adults with co-occurring insomnia (COGMUSE- AUT). Participants (n=15) will complete the cognitive training intervention for 60 minutes per day, 3 times per week for 6 weeks at home totaling to 18 hours. Weekly check-ins will be conducted by study staff over Teams to ensure adherence to the treatment and provide an opportunity for qualitative feedback on the game sessions played. During these 6 weeks, participants will fill out daily (2x/day) electronic sleep diaries and wear an actigraph device (GENEActiv). GENEActiv is a watch-like device that monitors light and movement activity., conditionsModule conditions: Autism Spectrum Disorder, conditions: Insomnia, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NA, interventionModel: SINGLE_GROUP, interventionModelDescription: Pilot test COGMUSE-AUT in a small sample of autistic adults with co-occurring insomnia on primary and secondary outcomes., primaryPurpose: OTHER, maskingInfo masking: NONE, enrollmentInfo count: 15, type: ESTIMATED, armsInterventionsModule interventions name: COGMUSE-AUT, outcomesModule primaryOutcomes measure: Objective Cognition-National Institute of Health Toolbox, secondaryOutcomes measure: Objective Slee-Daily Actigraphy, secondaryOutcomes measure: Subjective Sleep- Electronic Daily Sleep Diaries, secondaryOutcomes measure: Insomnia Severity Index, secondaryOutcomes measure: Sleep Habits Questionnaire, secondaryOutcomes measure: Pre-Sleep Arousal, secondaryOutcomes measure: WHO Quality of Life-BREF, secondaryOutcomes measure: Mood, secondaryOutcomes measure: Depression, secondaryOutcomes measure: Adaptive Behavior Assessment System (ABAS-III), secondaryOutcomes measure: Game-related experience (completed during intervention), eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False |
protocolSection identificationModule nctId: NCT06291285, orgStudyIdInfo id: NN7533-7587, secondaryIdInfos id: U1111-1285-7491, type: OTHER, domain: World Health Organization (WHO), briefTitle: A Study to Test How Either a Capsule or a Tablet With NDec (Decitabine and Tetrahydrouridine) Works in the Body of Healthy People, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-02-27, primaryCompletionDateStruct date: 2024-07-11, completionDateStruct date: 2024-07-11, studyFirstPostDateStruct date: 2024-03-04, lastUpdatePostDateStruct date: 2024-03-04, sponsorCollaboratorsModule leadSponsor name: Novo Nordisk A/S, class: INDUSTRY, descriptionModule briefSummary: This study will look at two different oral formulations and compare them. The medicine in the study is called NDec and it is a combination of two medicines (decitabine and tetrahydrouridine). Both medicines are new for the treatment of sickle cell disease, a rare blood disease. The purpose of the study is to compare the absorption of two different NDec versions (a tablet and a capsule). Participant will either get first the tablet and then the capsule, or the other way around. The order in which participant get them is decided by chance. The study will last for about 12 to 45 days depending on the wash-out period between the two stays in the clinic and from recruitment to the first study day., conditionsModule conditions: Healthy Volunteers, designModule studyType: INTERVENTIONAL, phases: PHASE1, designInfo allocation: RANDOMIZED, interventionModel: CROSSOVER, primaryPurpose: TREATMENT, maskingInfo masking: SINGLE, whoMasked: INVESTIGATOR, enrollmentInfo count: 48, type: ESTIMATED, armsInterventionsModule interventions name: Decitabine-THU, interventions name: Decitabine-THU, outcomesModule primaryOutcomes measure: AUC0-inf,DEC,SD: Area under the plasma decitabine concentration-time curve after a single dose, secondaryOutcomes measure: AUC0-inf,THU,SD: Area under the plasma tetrahydrouridine concentration-time curve after a single dose, secondaryOutcomes measure: Cmax,DEC,SD: Maximum plasma concentration of decitabine after a single dose, secondaryOutcomes measure: Cmax,THU,SD: Maximum plasma concentration of tetrahydrouridine after a single dose, secondaryOutcomes measure: t½,DEC,SD: Terminal half-life for decitabine after a single dose, secondaryOutcomes measure: t½,THU,SD: Terminal half-life for tetrahydrouridine after a single dose, secondaryOutcomes measure: tmax,DEC,SD: Time to maximum observed plasma decitabine concentration after a single dose, secondaryOutcomes measure: tmax,THU,SD:: Time to maximum observed plasma tetrahydrouridine concentration after a single dose, secondaryOutcomes measure: Maximum change from pre dose in dNA methyltransferase 1 (DNMT1) protein expression after a single dose, secondaryOutcomes measure: Maximum change from pre dose in cytidine deaminase (CDA) activity after a single dose, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 64 Years, stdAges: ADULT, contactsLocationsModule locations facility: ICON-Salt Lake City, city: Millcreek, state: Utah, zip: 84124, country: United States, geoPoint lat: 40.68689, lon: -111.87549, locations facility: Profil Institut für Stoffwechselforschung GmbH, city: Neuss, zip: 41460, country: Germany, geoPoint lat: 51.19807, lon: 6.68504, hasResults: False |
protocolSection identificationModule nctId: NCT06291272, orgStudyIdInfo id: FMHS 328-0723, briefTitle: Effect of Methylcellulose or Psyllium on Fermentation of inUlin Assessed USing MRI, acronym: RUFUS, statusModule overallStatus: RECRUITING, startDateStruct date: 2023-10-15, primaryCompletionDateStruct date: 2024-06-30, completionDateStruct date: 2024-10-30, studyFirstPostDateStruct date: 2024-03-04, lastUpdatePostDateStruct date: 2024-03-04, sponsorCollaboratorsModule leadSponsor name: University of Nottingham, class: OTHER, collaborators name: Quadram Institute Bioscience, descriptionModule briefSummary: Our challenge is to understand how fibre interacts with whole-gut function to alter colonic fermentation of FODMAPs. We will exploit the recent availability of a range of food grade modified celluloses which can form gels at body temperature to perform human studies to explore whether the beneficial effect of psyllium is unique or will be found with all gelling substances (4). We are currently performing the COCOA2 study using a modified methylcellulose (results awaited). We now wish to perform a pilot study to image what happens in the colon when methylcellulose is ingested to enable us to plan the next step in our research programme., conditionsModule conditions: Colon, Irritable, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: CROSSOVER, interventionModelDescription: 3 way cross -over, primaryPurpose: BASIC_SCIENCE, maskingInfo masking: TRIPLE, maskingDescription: Opaque plastic bags containing test meals prepared by some one not involved in analysis pf results, whoMasked: PARTICIPANT, whoMasked: INVESTIGATOR, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 18, type: ESTIMATED, armsInterventionsModule interventions name: Psyllium, interventions name: Methylcellulose, interventions name: Inulin, interventions name: Maltodextrin, outcomesModule primaryOutcomes measure: colonic gas volume, secondaryOutcomes measure: colonic gas volume at 6 hours, secondaryOutcomes measure: Breath hydrogen, secondaryOutcomes measure: Oro-cecal transit time, secondaryOutcomes measure: 24 hour breath hydrogen, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Nottingham Digestive Disease Centre, status: RECRUITING, city: Nottingham, state: Nottinghamshire, zip: NG7 2UH, country: United Kingdom, contacts name: Alaa Alhasani, BSc, role: CONTACT, phone: 01159429924, email: [email protected], contacts name: Robin Spiller, role: CONTACT, phone: +447824328319, email: [email protected], geoPoint lat: 52.9536, lon: -1.15047, hasResults: False |
protocolSection identificationModule nctId: NCT06291259, orgStudyIdInfo id: CTO 4081, briefTitle: Mpox Prospective Observational Cohort Study, acronym: MPOCS, statusModule overallStatus: RECRUITING, startDateStruct date: 2022-06-21, primaryCompletionDateStruct date: 2024-09, completionDateStruct date: 2024-09, studyFirstPostDateStruct date: 2024-03-04, lastUpdatePostDateStruct date: 2024-03-04, sponsorCollaboratorsModule leadSponsor name: Unity Health Toronto, class: OTHER, descriptionModule briefSummary: The goal of this multicentre prospective observational cohort study is to shed light on the following unknowns:1. The clinical manifestations of Mpox infection since the 2022 outbreak in Canada.2. The social and psychological impacts of Mpox infection since the 2022 outbreak in Canada3. The transmissibility of Mpox infection4. Viral shedding over time in infected individualsThe study is divided into Part 1 (corresponding to the acute phase of illness) and Part 2 (corresponding to the convalescent phase of the illness); part 2 will be optional. Participants enrolled during the acute phase of illness will complete part 1 of the study and will be invited to participate in Part 2 as well. Part 1 of the study will include the following three core components, at baseline and weekly (±3 days) until one week after the resolution of all symptoms (i.e. one week after complete healing of skin lesions):1. Collection of clinical data through chart review and research staff interviews with study participants2. Participant self-administered online questionnaires at baseline and a thrice-weekly 'acute phase participant diary'3. Specimen collection for Mpox-related testing Optional components for Part 1 include baseline-only, questionnaire-only, and frequent sampling.Other optional components for all participants include in the Image Atlas, an online database of clinical images of mpox, designed to provide clinicians and community members of what mpox looks like in real life, and the biobank, which will store research samples for potential future studies., conditionsModule conditions: Monkeypox, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 250, type: ESTIMATED, armsInterventionsModule, outcomesModule primaryOutcomes measure: Description of clinical manifestation, primaryOutcomes measure: Psychosocial impact, primaryOutcomes measure: Transmission-related aspects of mpox infection, primaryOutcomes measure: Virologic aspects of mpox infection over time, eligibilityModule sex: ALL, stdAges: CHILD, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: BC Centre For Excellence, status: RECRUITING, city: Vancouver, state: British Columbia, zip: V6Z 1Y6, country: Canada, contacts name: Brody Lyon, role: CONTACT, phone: 604-682-2344, phoneExt: 66230, email: [email protected], contacts name: Mark Hull, MD, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 49.24966, lon: -123.11934, locations facility: Unity Health Toronto, status: RECRUITING, city: Toronto, state: Ontario, zip: M5B 1T8, country: Canada, contacts name: Shreya Shah, role: CONTACT, phone: 416-360-4000, phoneExt: 77312, email: [email protected], contacts name: Darrell HS Tan, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 43.70011, lon: -79.4163, locations facility: University Health Network, status: RECRUITING, city: Toronto, state: Ontario, country: Canada, contacts name: Asmaa Mabrouk, role: CONTACT, phone: 416-340-4800, phoneExt: 2240, email: [email protected], contacts name: Sharon Walmsley, MD, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 43.70011, lon: -79.4163, hasResults: False |
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