hcaoaf/MoleculeQA · Datasets at Hugging Face

text stringlengths 3 799
" C
2313 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=CC=C(C=C1)CN2C3=CC=CC=C3C(=N2)OCC(=O)O
Question about this molecule: Which kind of action does this molecule have/exhibit?
Option A: It inhibits the denaturation of proteins.
Option B: It inhibits cell-wall biosynthesis.
Option C: It selectively inhibits mitosis and cell division.
Option D: It inhibits DNA synthesis.
" A
5732 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=CC=C(C=C1)C2=C(N3C=C(C=CC3=N2)C)CC(=O)N(C)C
Question about this molecule: Which kind of action does this molecule have/exhibit?
Option A: It has a rapid onset of action and short half-life.
Option B: It works quickly and has a short half-life.
Option C: It has a fast onset of action.
Option D: It displays rapid absorption and onset of action with the shortest half-life and duration of action.
" B
6579 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C=CC(=O)N
Question about this molecule: Which kind of action does this molecule have/exhibit?
Option A: It provides a totally novel mode of action with potential importance for diseases associated with ageing of the brain.
Option B: It is commonly associated with serum enzyme elevations during therapy and to rare instances of clinically apparent acute liver injury.
Option C: It may or may not have direct interaction with DNA for cancer induction.
Option D: It has direct actions on blood vessels and increases cardiac output.
" C
5284603 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CN1CC[C@]23[C@@H]4C(=O)CC[C@]2([C@H]1CC5=C3C(=C(C=C5)OC)O4)O
Question about this molecule: Which kind of action does this molecule have/exhibit?
Option A: It closes N-type voltage-operated calcium channels and opens calcium-dependent inwardly rectifying potassium channels.
Option B: It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors and modulates chloride currents through receptor channels.
Option C: It exhibits the actions of closing N-type voltage-operated calcium channels (OP2-receptor agonist) and opening calcium-dependent inwardly rectifying potassium channels (OP3 and OP1 receptor agonist).
Option D: It does not affect calcium influx and does not antagonize the actions of calcium channel blockers.
" A
115224 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1CSC(=NC#N)N1CC2=CN=C(C=C2)Cl
Question about this molecule: Which kind of action does this molecule have/exhibit?
Option A: It inhibits acetylcholinesterase.
Option B: It inhibits cholinesterase enzyme.
Option C: It binds irreversibly to acetylcholinesterase.
Option D: It cannot be broken down by acetylcholinesterase and the binding is irreversible.
" D
104838 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@H]([C@@H]1[C@H]2CC(=C(N2C1=O)C(=O)O)SCCN=CN)O
Question about this molecule: Which kind of action does this molecule have/exhibit?
Option A: It stimulates activation of new platelets and increases platelet aggregation.
Option B: Its effectiveness is enhanced when administered in combination with cilastatin.
Option C: It mediates a cytotoxic action on colorectal cancer cells by inducing cell arrest and apoptosis.
Option D: It inhibits the increase in promoter activity observed following overexpression of PKCdelta, constitutively active Ras, or MEKK1.
" B
3869 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(CCC1=CC=CC=C1)NCC(C2=CC(=C(C=C2)O)C(=O)N)O
Question about this molecule: Which kind of action does this molecule have/exhibit?
Option A: It exhibits the actions of being a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and a centrally acting neurotransmitter.
Option B: It competitively blocks adrenergic stimulation of β-receptors and α1-receptors.
Option C: It acts directly at alpha-adrenoceptors with selectivity for the alpha-1 adrenoceptor subtype similar to phenylephrine.
Option D: It has cardiac stimulant action without evoking vasoconstriction or tachycardia.
" B
6099959 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O.C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O.[Mg+2].[Mg+2].[Mg+2]
Question about this molecule: Which kind of action does this molecule have/exhibit?
Option A: It has a fast onset of action.
Option B: It works primarily through the high osmolarity of the solution.
Option C: It has a slow onset of action and exhibits a ""ceiling effect"".
Option D: It has a rapid onset of action and short half-life.
" B
68617 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CN[C@H]1CC[C@H](C2=CC=CC=C12)C3=CC(=C(C=C3)Cl)Cl
Question about this molecule: Which kind of action does this molecule have/exhibit?
Option A: It has little to no effect on norepinephrine or dopamine reuptake and does not antagonize α- or β-adrenergic, dopamine D2 or histamine H1 receptors.
Option B: It has little to no effect on norepinephrine or dopamine reuptake and does not antagonize α- or β-adrenergic, dopamine D2, or histamine H1 receptors.
Option C: It does not antagonize α- or β-adrenergic, dopamine D2 or histamine H1 receptors.
Option D: It acts as an excitotoxin on glutamate receptors such as NMDA, calcium dependent AMPA and kainite receptors.
" C
991 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCOP(=S)(OCC)OC1=CC=C(C=C1)[N+](=O)[O-]
Question about this molecule: Which kind of action does this molecule have/exhibit?
Option A: It inhibits acetylcholinesterase.
Option B: It inhibits cholinesterase enzyme.
Option C: It acts as an inhibitor of cholinesterase.
Option D: It acts by inhibition of cholinesterase activity.
" C
36811 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(CCC1=CC=C(C=C1)O)NCCC2=CC(=C(C=C2)O)O
Question about this molecule: Which kind of action does this molecule have/exhibit?
Option A: It mediates a cytotoxic action on colorectal cancer cells by inducing cell arrest and apoptosis.
Option B: It exhibits the actions of being a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and a centrally acting neurotransmitter.
Option C: It has cardiac stimulant action without evoking vasoconstriction or tachycardia.
Option D: It is used for the prevention and management of angina pectoris caused by coronary artery disease, but its onset of action is not rapid enough to offset an acute anginal episode.
" C
4054 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC12CC3CC(C1)(CC(C3)(C2)N)C
Question about this molecule: Which kind of action does this molecule have/exhibit?
Option A: It has systemic protective, curative, and eradicant action.
Option B: It has curative, protective, and eradicant action.
Option C: It is a highly potent, competitive, preferential dopamine D3 receptor antagonist, centrally active upon systemic administration.
Option D: It is a noncompetitive NMDA receptor antagonist.
" D
45375808 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@@H](C(=O)OC(C)C)N[P@](=O)(OC[C@@H]1[C@H]([C@@]([C@@H](O1)N2C=CC(=O)NC2=O)(C)F)O)OC3=CC=CC=C3
Question about this molecule: Which kind of action does this molecule have/exhibit?

" C

2313 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: C1=CC=C(C=C1)CN2C3=CC=CC=C3C(=N2)OCC(=O)O

Question about this molecule: Which kind of action does this molecule have/exhibit?

Option A: It inhibits the denaturation of proteins.

Option B: It inhibits cell-wall biosynthesis.

Option C: It selectively inhibits mitosis and cell division.

Option D: It inhibits DNA synthesis.

" A

5732 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: CC1=CC=C(C=C1)C2=C(N3C=C(C=CC3=N2)C)CC(=O)N(C)C

Question about this molecule: Which kind of action does this molecule have/exhibit?

Option A: It has a rapid onset of action and short half-life.

Option B: It works quickly and has a short half-life.

Option C: It has a fast onset of action.

Option D: It displays rapid absorption and onset of action with the shortest half-life and duration of action.

" B

6579 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: C=CC(=O)N

Question about this molecule: Which kind of action does this molecule have/exhibit?

Option A: It provides a totally novel mode of action with potential importance for diseases associated with ageing of the brain.

Option B: It is commonly associated with serum enzyme elevations during therapy and to rare instances of clinically apparent acute liver injury.

Option C: It may or may not have direct interaction with DNA for cancer induction.

Option D: It has direct actions on blood vessels and increases cardiac output.

" C

5284603 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: CN1CC[C@]23[C@@H]4C(=O)CC[C@]2([C@H]1CC5=C3C(=C(C=C5)OC)O4)O

Question about this molecule: Which kind of action does this molecule have/exhibit?

Option A: It closes N-type voltage-operated calcium channels and opens calcium-dependent inwardly rectifying potassium channels.

Option B: It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors and modulates chloride currents through receptor channels.

Option C: It exhibits the actions of closing N-type voltage-operated calcium channels (OP2-receptor agonist) and opening calcium-dependent inwardly rectifying potassium channels (OP3 and OP1 receptor agonist).

Option D: It does not affect calcium influx and does not antagonize the actions of calcium channel blockers.

" A

115224 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: C1CSC(=NC#N)N1CC2=CN=C(C=C2)Cl

Question about this molecule: Which kind of action does this molecule have/exhibit?

Option A: It inhibits acetylcholinesterase.

Option B: It inhibits cholinesterase enzyme.

Option C: It binds irreversibly to acetylcholinesterase.

Option D: It cannot be broken down by acetylcholinesterase and the binding is irreversible.

" D

104838 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: C[C@H]([C@@H]1[C@H]2CC(=C(N2C1=O)C(=O)O)SCCN=CN)O

Question about this molecule: Which kind of action does this molecule have/exhibit?

Option A: It stimulates activation of new platelets and increases platelet aggregation.

Option B: Its effectiveness is enhanced when administered in combination with cilastatin.

Option C: It mediates a cytotoxic action on colorectal cancer cells by inducing cell arrest and apoptosis.

Option D: It inhibits the increase in promoter activity observed following overexpression of PKCdelta, constitutively active Ras, or MEKK1.

" B

3869 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: CC(CCC1=CC=CC=C1)NCC(C2=CC(=C(C=C2)O)C(=O)N)O

Question about this molecule: Which kind of action does this molecule have/exhibit?

Option A: It exhibits the actions of being a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and a centrally acting neurotransmitter.

Option B: It competitively blocks adrenergic stimulation of β-receptors and α1-receptors.

Option C: It acts directly at alpha-adrenoceptors with selectivity for the alpha-1 adrenoceptor subtype similar to phenylephrine.

Option D: It has cardiac stimulant action without evoking vasoconstriction or tachycardia.

" B

6099959 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O.C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O.[Mg+2].[Mg+2].[Mg+2]

Question about this molecule: Which kind of action does this molecule have/exhibit?

Option A: It has a fast onset of action.

Option B: It works primarily through the high osmolarity of the solution.

Option C: It has a slow onset of action and exhibits a ""ceiling effect"".

Option D: It has a rapid onset of action and short half-life.

" B

68617 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: CN[C@H]1CC[C@H](C2=CC=CC=C12)C3=CC(=C(C=C3)Cl)Cl

Question about this molecule: Which kind of action does this molecule have/exhibit?

Option A: It has little to no effect on norepinephrine or dopamine reuptake and does not antagonize α- or β-adrenergic, dopamine D2 or histamine H1 receptors.

Option B: It has little to no effect on norepinephrine or dopamine reuptake and does not antagonize α- or β-adrenergic, dopamine D2, or histamine H1 receptors.

Option C: It does not antagonize α- or β-adrenergic, dopamine D2 or histamine H1 receptors.

Option D: It acts as an excitotoxin on glutamate receptors such as NMDA, calcium dependent AMPA and kainite receptors.

" C

991 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: CCOP(=S)(OCC)OC1=CC=C(C=C1)[N+](=O)[O-]

Question about this molecule: Which kind of action does this molecule have/exhibit?

Option A: It inhibits acetylcholinesterase.

Option B: It inhibits cholinesterase enzyme.

Option C: It acts as an inhibitor of cholinesterase.

Option D: It acts by inhibition of cholinesterase activity.

" C

36811 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: CC(CCC1=CC=C(C=C1)O)NCCC2=CC(=C(C=C2)O)O

Question about this molecule: Which kind of action does this molecule have/exhibit?

Option A: It mediates a cytotoxic action on colorectal cancer cells by inducing cell arrest and apoptosis.

Option B: It exhibits the actions of being a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and a centrally acting neurotransmitter.

Option C: It has cardiac stimulant action without evoking vasoconstriction or tachycardia.

Option D: It is used for the prevention and management of angina pectoris caused by coronary artery disease, but its onset of action is not rapid enough to offset an acute anginal episode.

" C

4054 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: CC12CC3CC(C1)(CC(C3)(C2)N)C

Question about this molecule: Which kind of action does this molecule have/exhibit?

Option A: It has systemic protective, curative, and eradicant action.

Option B: It has curative, protective, and eradicant action.

Option C: It is a highly potent, competitive, preferential dopamine D3 receptor antagonist, centrally active upon systemic administration.

Option D: It is a noncompetitive NMDA receptor antagonist.

" D

45375808 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: C[C@@H](C(=O)OC(C)C)N[P@](=O)(OC[C@@H]1[C@H]([C@@]([C@@H](O1)N2C=CC(=O)NC2=O)(C)F)O)OC3=CC=CC=C3

Question about this molecule: Which kind of action does this molecule have/exhibit?