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527923768+-3769-1.layout.json | [
"Do",
"you",
"have",
"answers",
"to",
"Rick's",
"questions?",
"GE",
"-----Original",
"Message-----",
"From:",
"Berry,",
"Barbara",
"W.",
"Sent:",
"Wednesday,",
"March",
"15,",
"2000",
"2:37",
"PM",
"To:",
"Evans,",
"Glenda",
"M.",
"Subject:",
"RE:",
"Your",
"Assistance!",
"Hi",
"Glenda,",
"Preliminarily,",
"Rick",
"has",
"2",
"questions:",
"1)",
"Does",
"he",
"want",
"2",
"suitc",
"passes",
"or",
"2",
"grandstand",
"tickets?",
"2)",
"The",
"fall",
"race",
"(9/9)",
"is",
"a",
"No",
"Bull",
"5",
"race.",
"Does",
"this",
"matter?",
"Basis",
"the",
"answers",
"1o",
"these",
"questions,",
"we",
"will",
"proceed",
"to",
"assist.",
"Thanks.",
"Hope",
"things",
"arc",
"going",
"well",
"with",
"you!",
"Best",
"regards,",
"Barbara",
"Original",
"Message-----",
"From:",
"Evans,",
"Gienda",
"M.",
"Sent:",
"Wednesday,",
"March",
"15,",
"2000",
"12:01",
"PM",
"To:",
"Sanders,",
"Rick",
"M.",
"Cc:",
"Berry,",
"Barbara",
"W.",
"Subject:",
"Your",
"Assistance!",
"Tommy",
"asked",
"that",
"I",
"contact",
"you",
"regarding",
"a",
"request",
"which",
"he",
"received",
"this",
"morning.",
"Congressman",
"Tom",
"Bliley's",
"office",
"called",
"and",
"asked",
"for",
"two",
"(2)",
"race",
"tickets",
"Richmond,",
"VA",
"cither",
"May",
"6",
"and/or",
"September",
"9.",
"Plcasc",
"Ict",
"me",
"know",
"if",
"we",
"will",
"be",
"able",
"to",
"obtain",
"tickets",
"for",
"Bliley.",
"Thanks!",
"Glenda",
"Evans",
"RJR1283003510",
"70007",
"D368",
"69.¢€",
"26./2S"
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0060143407-4.layout.json | [
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"risk",
"estimates",
"may",
"be",
"due",
"to",
"the",
"substantial",
"difference",
"in",
"the",
"number",
"of",
"surrogates",
"used",
"in",
"the",
"two",
"studies.",
"Two-thirds",
"of",
"the",
"case",
"interviews",
"in",
"the",
"Brownson",
"study",
"were",
"conducted",
"using",
"surrogates,",
"compared",
"to",
"a",
"little",
"over",
"one-third",
"in",
"the",
"Fontham",
"It",
"is",
"hard",
"to",
"imagine",
"how",
"a",
"surrogate",
"could",
"provide",
"useful",
"information",
"about",
"the",
"workplace",
"ETS",
"exposure",
"of",
"a",
"deceased",
"case.",
"In",
"view",
"of",
"the",
"Brownson",
"study’s",
"reliance",
"on",
"surrogate",
"interview",
"data,",
"the",
"Fontham",
"study",
"would",
"appear",
"to",
"provide",
"more",
"relizble",
"data",
"on",
"workplace",
"ETS",
"exposure.",
"(The",
"Brownson",
"and",
"Fontham",
"studies",
"alsc",
"differed",
"with",
"respect",
"to",
"risk",
"from",
"expasure",
"to",
"spousal",
"sroking,",
"so",
"it",
"is",
"not",
"clear",
"that",
"poorer",
"data",
"are",
"responsible",
"for",
"these",
"differences.)",
"Levois",
"and",
"Layard",
"performed",
"a",
"meta-analysis",
"using",
"all",
"13",
"occupational",
"risk",
"estimates",
"and",
"found",
"no",
"association",
"between",
"workplace",
"ETS",
"exposure",
"and",
"lung",
"cancer$®",
"The",
"overall",
"refative",
"risk",
"was",
"1.00,",
"with",
"a",
"85",
"percent",
"confidence",
"interval",
"of",
"0.92",
"to",
"1.09.",
"In",
"&",
"separate",
"meta-analysis",
"using",
"only",
"the",
"8",
"US.",
"studies,",
"the",
"relative",
"risk",
"dropped",
"slightly",
"to",
"0.97,",
"with",
"a",
"95",
"percent",
"confidence",
"interval",
"of",
"0.89",
"to",
"1.07.",
"Therefore,",
"had",
"OSHA",
"performed",
"2",
"meta-analysis,",
"it",
"seems",
"likely",
"that",
"it",
"would",
"bave",
"found",
"no",
"increased",
"lung",
"cancer",
"risk",
"from",
"occupational",
"ETS",
"exposure.",
"Although",
"the",
"Fontham",
"study",
"may",
"have",
"the",
"most",
"dependable",
"workplace",
"data,",
"OSHA",
"has",
"been",
"criticized",
"for",
"Tgnoring",
"the",
"other",
"workplace",
"studies",
"and",
"not",
"Derforming",
"2",
"meta-analysis,",
"as",
"did",
"EPA.",
"An",
"alternative",
"approach",
"would",
"be",
"to",
"9o",
"the",
"estimates",
"of",
"risk",
"from",
"spousal",
"exposure,",
"Warkplace",
"risk",
"could",
"then",
"be",
"estimated",
"by",
"comparing",
"time-activity",
"and",
"exposure",
"patterns",
"in",
"residental",
"and",
"occupational",
"settings.",
"The",
"outcome",
"would,",
"however,",
"depend",
"largely",
"on",
"the",
"choice",
"of",
"a",
"no-threshold",
"vs.",
"threshold",
"model,",
"as",
"discussed",
"in",
"the",
"previous",
"section.",
".",
"OCCUPATIONAL",
"ETS",
"EXPOSURE",
"OSHA",
"estimated",
"that",
"between",
"13.8",
"and",
"48.7",
"percent",
"of",
"nonsmoking",
"workers",
"are",
"potentially",
"exposed",
"to",
"ETS",
"at",
"their",
"worksite,",
"The",
"higher",
"number",
"9!",
"Butler,",
"W.J.",
"Workplacs",
"Exposure",
"to",
"ETS",
"and",
"Lung",
"Cancer:",
"A",
"More",
"Detailed",
"Presentation",
"of",
"the",
"Data",
"from",
"a",
"Negative",
"Study,",
"Browrson",
"et",
"al,",
"(1992).",
"Submitted",
"to",
"OSH4A",
"Docket",
"H-122,",
"August",
"1994,",
"92",
"15",
"the",
"Brownson",
"study,",
"402",
"(65",
"percent)",
"of",
"the",
"618",
"case",
"interviews",
"were",
"with",
"surrogates,",
"compared",
"to",
"241",
"(37",
"percent)",
"of",
"the",
"653",
"case",
"interviews",
"in",
"the",
"Fontham",
"study.",
"23",
"Levois,",
"M.E.",
"and",
"Layard,",
"MW,",
"Inconsistency",
"between",
"workplace",
"and",
"spousal",
"studies",
"of",
"environmental",
"tobaceo",
"smeke",
"and",
"lung",
"cancer.",
"Regulatory",
"Texicol.",
"and",
"Pharmesol,",
"v.",
"18,",
"1994",
"p.",
"309.",
"DRAFT",
"SUBJECT",
"TO",
"REVISION.",
"NOT",
"FOR",
"QUOTATION",
"OR",
"ATTRIBUTION.",
"@o25/038",
"6694089706"
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"Edned",
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")",
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"white",
"o",
"neas-white",
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"McFeely",
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"16:",
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"onsei",
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"puberty",
"in",
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"Endocnnol",
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"1982",
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"FAE.",
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"nature",
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"time",
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"nthe",
"female",
"mouse.",
"Q)",
"Exp",
"Physiol",
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"1930",
"Donovan",
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"Werll",
"ten",
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"J):",
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"RR.",
"Laird",
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"cles.",
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"Febger,",
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"bz",
"%",
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"™N",
"Evans",
"New",
"York,",
"Harper",
"and",
"Row,",
"1973,",
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"132,",
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"O,",
"Kantero",
"RL-",
"A",
"statistica)",
"analysis",
"ol",
"the",
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"Fanriz®",
"girly",
"and",
"ther",
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"Acla",
"Ostet",
"Gyneco)",
"Scand[Supp}i4:",
"1-36.",
"19",
"Petn",
"E",
"Untersuchunge",
"n2ur",
"Erdbbedingthendet",
"Menacche.",
"2",
"Morpho!",
"Anthropol",
"13",
"43-48.19°8",
".",
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"M",
"§",
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"Comparative",
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"ameauy",
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"Genel",
"Hum",
"2-87:102,",
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"IM.",
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"and",
"Development.",
"Insutut",
"Intern,",
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"Foundazuine",
"A",
"Beselh,",
"1960,",
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"1-28",
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"EC,",
"Krohn",
"PL:",
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"numben",
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"J",
"E",
"inod",
"23:",
"469495,",
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"Arrested",
"development",
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"the",
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"Cornell",
"Vet",
"16:)-19,",
"1926",
".",
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"MW:",
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"hamster:",
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")",
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"N:",
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"female",
"gemital",
"mm",
"1",
"mink",
"heterozy.",
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"Heggeda)",
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"(ihadow",
"gene)",
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"Vet",
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"&:",
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"1968",
".",
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"RL,",
"Koop",
"CE.",
"e1",
"a}:",
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"as",
"@",
"simply",
"inti¢rited",
"malformation.",
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"189:",
"B13-816.",
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"Gall",
"JC",
"Jr,",
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"new",
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"Jdermatoglyphic",
"ltvlormulum",
"wnd",
"partiel",
"dophication",
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"the",
"female",
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"J",
"Peciasr",
"77:109.116,",
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"J",
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0011977758-0.layout.json | [
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"DATE:",
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531376115+-6129-7.layout.json | [
"RIRI",
"News",
"Report",
"'",
"May",
"6,",
"1997",
"But",
"a",
"decision",
"to",
"allow",
"this",
"sponsorship",
"to",
"continue",
"would",
"be",
"met",
"with",
"fury",
"from",
"the",
"antismoking",
"lobby,",
"especially",
"as",
"some",
"European",
"countries,",
"including",
"Germany,",
"already",
"have",
"such",
"a",
"ban.",
"Moreover,",
"a",
"report",
"by",
"Euromonitot,",
"the",
"market",
"research",
"consultancy,",
"to",
"be",
"published",
"next",
"month",
"says",
"restrictions",
"on",
"other",
"forms",
"of",
"marketing",
"mean",
"“the",
"route",
"of",
"sponsoring",
"major",
"sporting",
"events",
"that",
"achieve",
"wide",
"coverage",
"on",
"television",
"and",
"other",
"media",
"has",
"become",
"the",
"preferred",
"option”.",
"This",
"is",
"particularly",
"important",
"in",
"the",
"UK,",
"with",
"well-established",
"links",
"between",
"Benson",
"&",
"Hedges",
"and",
"cricket;",
"Embassy",
"and",
"darts.",
"There",
"is",
"also",
"the",
"question",
"of",
"direct",
"mail.",
"This",
"does",
"not",
"attract",
"the",
"same",
"leve!",
"of",
"hostility",
"from",
"the",
"antismoking",
"lobby",
"as",
"poster",
"advertising,",
"because",
"billboards",
"get",
"a",
"widespread",
"audience",
"which",
"includes",
"children",
"and",
"other",
"nonsmokers",
"who",
"may",
"be",
"tempted",
"to",
"take",
"up",
"the",
"habit.",
"Even",
"so,",
"the",
"prospect",
"that",
"at",
"least",
"some",
"of",
"the",
"GBP",
"50",
"million",
"a",
"year",
"spent",
"on",
"tobacco",
"advertising",
"will",
"switch",
"to",
"direct",
"marketing",
"can",
"scarcely",
"be",
"what",
"campaigners",
"for",
"an",
"advertising",
"ban",
"had",
"in",
"mind.",
"But",
"there",
"are",
"already",
"signs",
"that",
"tobacco",
"companies",
"are",
"increasing",
"their",
"activities",
"in",
"this",
"area.",
"For",
"example,",
"Silk",
"Cut",
"has",
"begun",
"producing",
"a",
"free",
"magazine",
"for",
"its",
"smokers.",
"“Many",
"of",
"the",
"promotions",
"on",
"cigarette",
"packets",
"are",
"about",
"collecting",
"data.",
"They",
"are",
"working",
"very",
"hard",
"at",
"building",
"up",
"loyalty,”",
"says",
"David",
"Robottom,",
"director",
"of",
"development",
"at",
"the",
"Direct",
"Marketing",
"Association.",
"Including",
"direct",
"mail",
"in",
"a",
"ban",
"would",
"not",
"be",
"straightforward,",
"however.",
"David",
"Muir,",
"head",
"of",
"new",
"business",
"at",
"ad",
"agency",
"Ogilvy",
"&",
"Mather,",
"which",
"has",
"analyzed",
"the",
"impact",
"of",
"a",
"tobacco",
"ban,",
"points",
"out",
"many",
"direct",
"mail",
"promotions",
"are",
"delivered",
"as",
"letters",
"drawing",
"attention",
"to",
"special",
"offers.",
"These",
"cannot",
"easily",
"be",
"distinguished",
"from",
"other",
"forms",
"of",
"correspondence",
"sent",
"out",
"by",
"companies.",
"“Direct",
"mail",
"is",
"very",
"hard",
"to",
"define",
"for",
"the",
"purposes",
"of",
"legislation,”",
"he",
"says.",
"So",
"the",
"government",
"faces",
"some",
"hard",
"questions",
"on",
"the",
"scope",
"of",
"a",
"new",
"restriction,",
"In",
"deciding",
"its",
"form,",
"it",
"is",
"more",
"a",
"matter",
"of",
"being",
"spoiled",
"for",
"choice.",
"Ministers",
"could",
"take",
"primary",
"legislation",
"through",
"the",
"UK",
"parliament,",
"or",
"try",
"to",
"tilt",
"the",
"balance",
"in",
"the",
"EU",
"council",
"of",
"health",
"ministers",
"by",
"supporting",
"an",
"EU-wide",
"ban.",
"Such",
"a",
"ban",
"currently",
"lacks",
"the",
"mgjority",
"it",
"needs.",
"This",
"would",
"particularly",
"effect",
"countries",
"with",
"liberal",
"laws,",
"such",
"as",
"the",
"Netherlands",
"and",
"Greece.",
"Source:",
"Financial",
"Times;",
"05-May-97",
"Author:",
"Alison",
"Smith",
"New",
"U.K.",
"GOVERNMENT",
"UNLIKELY",
"TO",
"AFFECT",
"EU",
"ToBACCO",
"ADS",
"REGULATION",
"FoRr",
"NEXT",
"12",
"MONTHS",
"The",
"newly-elected",
"Labour",
"government",
"is",
"unlikely",
"to",
"give",
"the",
"go-ahead",
"to",
"a",
"Europe-wide",
"ban",
"on",
"tobacco",
"advertising",
"by",
"removing",
"the",
"U.K.’s",
"blocking",
"vote",
"on",
"a",
"European",
"Union",
"directive",
"within",
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501565196.layout.json | [
"September",
"7,",
"1971",
"Mr,",
"A.",
"H.",
"Galloway:",
"Philip",
"Morris",
"has",
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"Marlboro",
"Lights",
"in",
"New",
"England.",
"It",
"is",
"advertised",
"as",
"having",
"14",
"mg.",
"''tar,\"",
"1.1",
"mg.",
"nicotine.",
"You",
"will",
"note",
"the",
"caution",
"notice",
"on",
"the",
"side",
"of",
"the",
"enclosed",
"package",
"is",
"very",
"difficult",
"to",
"read",
"and",
"at",
"certain",
"angles",
"is",
"illegible.",
"It",
"occurs",
"to",
"me",
"that",
"this",
"could",
"cause",
"the",
"industry",
"some",
"criticism",
"and",
"that",
"we",
"may",
"be",
"well",
"advised",
"to",
"call",
"this",
"to",
"the",
"attention",
"of",
"that",
"cowmpany.",
"It",
"seems",
"appropriate",
"to",
"me",
"that",
"you",
"may",
"want",
"to",
"discuss",
"this",
"with",
"Joe",
"Cullman,",
"in",
"view",
"of",
"his",
"position",
"with",
"the",
"Tobacco",
"Institute",
"and",
"the",
"accomplishments",
"we",
"hope",
"the",
"Institute",
"will",
"be",
"able",
"to",
"carry",
"out",
"in",
"the",
"near",
"future.",
"The",
"alternatives",
"are",
"for",
"Jack",
"Roemer",
"to",
"discuss",
"this",
"with",
"their",
"counsel",
"or",
"I",
"can",
"discuss",
"it",
"with",
"Ross",
"Millhiser,",
"I",
"think",
"discussion",
"with",
"Joe",
"Cullman",
"will",
"accomplish",
"more.",
"Regpectfully,",
"William",
"S.",
"Swmith",
"WSS~-ohf",
"cc:Mr,",
"H.",
"C.",
"Roemer",
"961S",
"96194"
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2046807567_7643-52.layout.json | [
"637",
"15303",
"FEILIP",
"MORRIS",
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2073874045_4052-4.layout.json | [
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"Johnson,",
"Celanese",
"Acetate,",
"Charlotte,",
"NC",
"28232",
"USA.",
"The",
"high",
"speeds",
"and",
"numerous",
"contact",
"points",
"between",
"the",
"tow",
"band",
"and",
"various",
"air",
"spreaders",
"end",
"roll",
"sets",
"results",
"in",
"a",
"significant",
"potential",
"for",
"the",
"build-up",
"of",
"static",
"charge",
"during",
"filter",
"rodmaking,",
"In",
"order",
"to",
"study",
"this",
"phenomenon,",
"a",
"static",
"monitoring",
"system",
"comprised",
"of",
"a",
"multi-channel",
"electrostatic",
"field",
"meter",
"and",
"a",
"high-speed",
"data",
"acquisition",
"system",
"was",
"installed",
"on",
"a",
"KDF-3/AF-3E.",
"The",
"probes,",
"which",
"measure",
"the",
"electrostatic",
"field",
"strength,",
"were",
"located",
"above",
"the",
"tow",
"band",
"near",
"each",
"of",
"three",
"sets",
"of",
"AC-driven",
"static",
"suppression",
"bars.",
"Measurements",
"were",
"collected",
"and",
"analyzed",
"for",
"each",
"sensor",
"with",
"static",
"bars",
"on",
"and",
"off.",
"The",
"relationship",
"between",
"the",
"electrostatic",
"field",
"strength",
"at",
"the",
"three",
"positions",
"will",
"be",
"reviewed.",
"In",
"addition,",
"a",
"factorial",
"trial",
"was",
"conducted",
"to",
"evaluate",
"the",
"impact",
"of",
"key",
"parameters",
"on",
"rodmaking",
"and",
"filter",
"rod",
"performance",
"with",
"and",
"without",
"static",
"bars.",
"The",
"four",
"independent",
"variables",
"were",
"rodmaking",
"speed,",
"threaded",
"roll",
"pressure,",
"tow",
"band",
"width",
"exiting",
"the",
"plasticizer",
"booth,",
"and",
"AC",
"power",
"level",
"to",
"the",
"static",
"bars.",
"The",
"purposc",
"of",
"the",
"latter",
"was",
"to",
"simulate",
"the",
"effect",
"of",
"charge",
"bleed",
"off",
"due",
"to",
"fouling",
"of",
"the",
"static",
"bars",
"over",
"time.",
"Rodmaker",
"response",
"variables",
"include",
"the",
"difference",
"in",
"tow",
"band",
"width",
"and",
"transport",
"jet",
"air",
"usage.",
"Filter",
"response",
"variables",
"include",
"rod",
"yield",
"(i.e.,",
"encapsulated",
"pressure",
"drop",
"at",
"target",
"weight),",
"filter",
"rod",
"firmness,",
"and",
"rod-to-rod",
"pressure",
"drop,",
"weight,",
"and",
"circumference",
"variability.",
"Detailed",
"analysis",
"of",
"the",
"factorial",
"trial",
"results",
"will",
"be",
"presented",
"as",
"well",
"as",
"the",
"future",
"direction",
"of",
"this",
"research.",
"410",
"PM",
"TuesDAY",
"63,",
"THE",
"INFLUENCE",
"OF",
"PLASTICIZER",
"ON",
"CIGARETTE",
"FIITER",
"PERFOR-",
"MANCE.",
"Steven",
"A.",
"Wilson,",
"Eastman",
"Chemical",
"Company,",
"Kingsport,",
"TN",
"37662",
"USA.",
"Plasticizers",
"have",
"traditionally",
"been",
"added",
"to",
"cigarette",
"filters",
"to",
"increase",
"filter",
"firmness",
"and",
"have",
"been",
"found",
"to",
"influence",
"smoke",
"taste.",
"Though",
"the",
"mechanisms",
"for",
"increasing",
"filter",
"firmness",
"have",
"been",
"well",
"studied,",
"the",
"influence",
"of",
"plasticizer",
"on",
"smoke",
"chemistry",
"is",
"complicated",
"and",
"has",
"been",
"difficult",
"to",
"study.",
"In",
"this",
"paper,",
"we",
"present",
"the",
"results",
"of",
"an",
"aging",
"study",
"on",
"ccllulose",
"acetate",
"filters",
"in",
"which",
"a",
"set",
"of",
"filters",
"was",
"made",
"with",
"a",
"range",
"of",
"triacetin",
"plasticizer",
"content",
"and",
"extensively",
"evaluated",
"by",
"measuring",
"their",
"performance",
"in",
"full",
"flavor",
"cigarettes",
"over",
"several",
"months.",
"Traditional",
"smoke",
"testing",
"for",
"tar,",
"nicotine,",
"and",
"water",
"deliveries",
"shows",
"little",
"change",
"during",
"the",
"first",
"few",
"months",
"of",
"fitter",
"aging",
"under",
"controlted",
"conditions,",
"but",
"the",
"smoke",
"chemistry",
"is",
"known",
"to",
"change",
"significantly",
"during",
"the",
"first",
"few",
"weeks.",
"One",
"key",
"change",
"is",
"due",
"to",
"the",
"filter’s",
"selective",
"filtration",
"properties,",
"which",
"we",
"see",
"decreasing",
"as",
"the",
"plasticizer",
"diffuses",
"into",
"the",
"filter’s",
"fibers.",
"During",
"this",
"work,",
"the",
"smoke",
"chemistry",
"changes",
"were",
"closely",
"monitored",
"with",
"a",
"liquid",
"o",
"£2486",
"0102",
"AT",
"v",
"2",
"ey",
"s"
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50517337-7342-1.layout.json | [
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"(20)",
"was",
"adopted.",
"This",
"procedure",
"differed",
"from",
"that",
"of",
"Cheney",
"and",
"Sprent",
"in",
"that",
"the",
"dosage",
"of",
"CsA",
"was",
"higher",
"{15",
"vs.",
"10",
"mg/",
"kg/day),",
"and",
"immunosuppression",
"with",
"CsA",
"was",
"initiated",
"at",
"the",
"time",
"of",
"bone",
"marrow",
"transplantation",
"as",
"opposed",
"to",
"3",
"days",
"after",
"bone",
"marrow",
"transplantation.",
"In",
"addition",
"to",
"the",
"above",
"changes,",
"3-4",
"weeks",
"instead",
"of",
"8-12-week-old",
"animals",
"were",
"used",
"because",
"it",
"had",
"been",
"found",
"that",
"syngeneic",
"GVHD",
"was",
"induced",
"more",
"readily",
"in",
"young",
"compared",
"to",
"old",
"rats",
"(12,",
"13,",
"21).",
"Lethally",
"irradiated",
"DBA/2",
"mice",
"were",
"reconstituted",
"with",
"syngeneic",
"mar-",
"row",
"and",
"then",
"treated",
"for",
"21",
"days",
"with",
"either",
"CsA",
"or",
"diluent.",
"Within",
"1",
"week",
"after",
"cessation",
"of",
"CsA",
"treatment,",
"animals",
"began",
"to",
"exhibit",
"clinical",
"signs",
"characteristic",
"of",
"acute",
"GVHD:",
"runting",
"loss),",
"hunched",
"posture,",
"and",
"development",
"of",
"severe",
"diarrhea",
"(22).",
"The",
"syngeneic-GVHD-like",
"disease",
"(syngeneic",
"GVHD)",
"that",
"developed",
"after",
"discontinuing",
"CsA",
"treatment",
"was",
"fatal",
"for",
"all",
"the",
"animals",
"that",
"survived",
"the",
"CsA",
"treatment",
"period",
"(Fig.",
"1A).",
"The",
"percentage",
"of",
"survival",
"shown",
"in",
"Figure",
"1",
"has",
"been",
"adjusted",
"to",
"100%",
"and",
"represents",
"animals",
"that",
"were",
"alive",
"at",
"day",
"21",
"after",
"bone",
"marrow",
"transplantation.",
"Typically,",
"50%",
"of",
"CsA-treated",
"bone-marrow-reconstituted",
"animals",
"died",
"within",
"the",
"1st",
"7-10",
"days",
"posttransplantation.",
"In",
"contrast,",
"no",
"mortality",
"or",
"clinical",
"abnormalities",
"were",
"observed",
"in",
"normal",
"DBA/2",
"mice",
"treated",
"comparably",
"with",
"CsA",
"(data",
"not",
"shown).",
"A",
"majority",
"of",
"the",
"reconstituted",
"animals",
"that",
"survived",
"the",
"complete",
"course",
"of",
"CsA",
"died",
"within",
"the",
"1st",
"4",
"weeks",
"after",
"cessation",
"of",
"treatment.",
"In",
"all",
"experiments,",
"animals",
"that",
"appeared",
"moribund",
"were",
"sac-",
"rificed",
"and",
"were",
"recorded",
"as",
"mortalities.",
"Death",
"of",
"the",
"treated",
"mice",
"was",
"preceded",
"by",
"weight",
"loss",
"and",
"severe",
"diarrhea.",
"The",
"weight",
"profiles",
"of",
"diluent",
"control",
"and",
"CsA-treated",
"mice",
"are",
"depicted",
"in",
"Figure",
"1B.",
"During",
"the",
"CsA-treatment",
"period",
"(days",
"0-21),",
"both",
"control",
"and",
"CsA-treatment",
"groups",
"increased",
"in",
"average",
"body",
"weight.",
"However,",
"over",
"the",
"remainder",
"of",
"the",
"ex-",
"periment,",
"CsA-treated",
"animals",
"lost",
"weight,",
"falling",
"to",
"25-30%",
"of",
"day",
"21",
"posttransplant",
"body",
"weight.",
"Diluent",
"control",
"animals",
"gained",
"weight",
"over",
"the",
"entire",
"period",
"of",
"the",
"experiment",
"and",
"displayed",
"no",
"sign",
"of",
"overt",
"disease,",
"with",
"all",
"of",
"the",
"animals",
"surviving.",
"While",
"we",
"were",
"able",
"to",
"induce",
"syngeneic",
"GVHD",
"in",
"DBA/2",
"mice",
"(H-2%),",
"we",
"were",
"unable",
"to",
"do",
"so",
"when",
"an",
"identical",
"indue-",
"tion",
"protocol",
"was",
"performed",
"on",
"BALB/c",
"mice",
"(H-29).",
"As",
"seen",
"in",
"Figure",
"2A,",
"BALB/c",
"animals",
"did",
"not",
"readily",
"develop",
"a",
"fatal",
"disease",
"as",
"the",
"CsA-treated",
"mice",
"had",
"a",
"survival",
"rate",
"similar",
"to",
"the",
"diluent-treated",
"mice.",
"In",
"addition,",
"following",
"cessation",
"of",
"CsA,",
"the",
"treated",
"animals",
"gained",
"weight",
"at",
"a",
"rate",
"equal",
"to",
"that",
"of",
"control",
"animals",
"(Fig.",
"2B).",
"Taken",
"together,",
"this",
"data",
"would",
"BRYSON",
"ET",
"AL.",
"1043",
"A",
"|",
"100w",
"I’_.Y",
"t\"-'“)l",
"80",
".‘o\\",
"B—",
"B",
"Controt",
"[",
"T",
"1",
"2",
"60",
"*",
"§",
"4w",
"“R",
"5",
"*..",
"a",
"e",
".",
"20",
"i",
"%,",
"(=30)",
":",
"\"",
"oLb—f—4",
"s",
"0",
"20",
"30",
"40",
"50",
"&0",
"70",
"80",
"Time",
"(days)",
"after",
"Transpiont",
"B",
"20",
"!",
".J../I.H'le.",
"\"",
"ul",
"3",
"ol",
":;:",
"15}",
":",
"R",
"@",
"0",
"¥",
".‘.’:’",
"_9®%-g0",
"§",
"10",
"s",
"Sheemegsin",
"'\\.",
"z",
"w9}",
"§",
"3",
"Ly",
"3",
"121",
"o",
"0",
"10",
"20",
"30",
"40",
"50",
"80",
"70",
"80",
"Time",
"(days)",
"ofter",
"Transplant",
"FiGUrE",
"1.",
"(A)",
"Survival",
"curves",
"of",
"DBA/2",
"mice",
"following",
"the",
"induc-",
"tion",
"of",
"syngeneic",
"GVHD.",
"Mice",
"were",
"irradiated,",
"reconstituted",
"with",
"syngeneic",
"marrow,",
"and",
"treated",
"with",
"CsA,",
"15",
"mg/kg/day",
"for",
"21",
"days",
"as",
"described",
"in",
"the",
"Materials",
"end",
"Methods",
"section.",
"Percentage",
"of",
"survival",
"was",
"adjusted",
"to",
"100",
"percent,",
"which",
"represents",
"animals",
"that",
"were",
"alive",
"at",
"day",
"21",
"after",
"bone",
"marrow",
"transplantation.",
"The",
"data",
"presented",
"are",
"the",
"pooled",
"results",
"from",
"3",
"experiments.",
"The",
"numbers",
"in",
"parentheses",
"represent",
"the",
"number",
"of",
"animals",
"in",
"each",
"treatment",
"group.",
"All",
"the",
"irradiation",
"control",
"animals",
"(n=30)",
"were",
"dead",
"by",
"day",
"15",
"posttransplan-",
"tation.",
"(B)",
"Weight",
"profiles",
"of",
"DBA/2",
"mice",
"following",
"induction",
"of",
"syngeneic",
"GVHD,",
"Animals",
"within",
"each",
"group",
"were",
"weighed",
"three",
"times",
"weekly",
"post-CsA",
"treatment,",
"and",
"the",
"average",
"weight",
"for",
"each",
"group",
"determined.",
"The",
"numbers",
"in",
"parentheses",
"represent",
"the",
"number",
"of",
"animals",
"weighed",
"at",
"each",
"time",
"point.",
"The",
"data",
"are",
"representative",
"of",
"3",
"experiments.",
"indicate",
"that",
"the",
"inducibility",
"of",
"syngeneic",
"GVHD",
"is",
"not",
"linked",
"to",
"the",
"MHC",
"H-2¢",
"haplotype.",
"Histology.",
"Tissue",
"samples",
"from",
"CsA-treated,",
"syngeneic",
"hone-",
"marrow-reconstituted",
"mice",
"with",
"clinical",
"symptoms",
"of",
"disease,",
"as",
"well",
"as",
"diluent",
"controls",
"and",
"normal",
"mice",
"treated",
"with",
"CsA,",
"were",
"examined",
"for",
"pathologic",
"changes.",
"Pathologic",
"changes",
"were",
"observed",
"in",
"the",
"large",
"intestine,",
"spleen,",
"and",
"thymus",
"of",
"CsA-",
"treated",
"animals",
"when",
"compared",
"to",
"diluent",
"controls.",
"In",
"general,",
"no",
"differences",
"in",
"pathology",
"were",
"observed",
"between",
"diluent",
"controls",
"and",
"normal",
"mice",
"treated",
"with",
"CsA.",
"Consequently,",
"only",
"the",
"data",
"from",
"the",
"diluent",
"control",
"animals",
"are",
"represented.",
"Although",
"the",
"observed",
"changes",
"did",
"not",
"represent",
"the",
"full",
"range"
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"to",
"estimate",
"mutagenicity;",
"Rev.",
"=",
"Revertants;",
"Cig.",
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"EPA",
"calculation",
"used",
"a",
"value",
"of",
"Z",
"=",
"1L.75.",
"As",
"a",
"result,",
"it",
"came",
"up",
"with",
"an",
"estimate",
"of",
"lung",
"cancer",
"deaths",
"about",
"3C00",
"Somewhat",
"gz",
"Fontham,",
"et.al.,",
"data",
"even",
"though",
"WMM",
"1.29",
"for",
"the",
"calculations",
"presented",
"above.",
"he",
"EPA",
"results",
"showed",
"about",
"71",
"percent",
"of",
"the",
"lung",
"cancer",
"deaths",
"0",
"Be",
"due",
"to",
"Hackground",
"ETS,",
"either",
"by",
"enhancing",
"the",
"effect",
"of",
"spousal",
"ETS",
"or",
"by",
"acting",
"directly",
"on",
"non-smekers",
"net",
"The",
"effect",
"of",
"changing",
"Z",
"can",
"also",
"be",
"seen",
"by",
"re-calculating",
"the",
"numbers",
"in",
"table",
"1",
"for",
"a",
"different",
"value",
"of",
"Z.",
"For",
"example,",
"in",
"illustration",
"[",
"above,",
"if",
"Z",
"is",
"doubled",
"to",
"5.2,",
"the",
"number",
"of",
"lung",
"cancer",
"deaths",
"drops",
"fram",
"2795",
"to",
"1820",
"and",
"the",
"percentage",
"due",
"to",
"hackground",
"ETS",
"drops",
"from",
"55",
"percent",
"to",
"29",
"percent.",
"Furthermore,",
"over",
"one",
"helf",
"of",
"the",
"deaths",
"attributable",
"to",
"background",
"ETS",
"come",
"from",
"those",
"individuals",
"unexposed",
"to",
"spousal",
"ETS",
"meaning",
"that",
"the",
"effect",
"of",
"background",
"ETS",
"on",
"enhancing",
"spousal",
"ETS",
"drops",
"in",
"relative",
"terms.",
"There",
"are",
"other",
"concerns",
"about",
"this",
"method",
"of",
"Jdetermining",
"the",
"contribution",
"of",
"background",
"ETS.",
"Oge",
"source",
"of",
"uncertainty",
"is",
"the",
"possible",
"variation",
"of",
"background",
"exposure",
"over",
"time.",
"Such",
"behavior",
"is",
"very",
"likely.",
"Whereas",
"spousal",
"ETS",
"exposure",
"is",
"likely",
"to",
"be",
"rather",
"constant",
"over",
"time",
"to",
"the",
"degree",
"that",
"the",
"spouse",
"continues",
"to",
"smoke,",
"background",
"ETS",
"for",
"a",
"given",
"individual",
"could",
"vary",
"substantially.",
"Changing",
"jobs",
"or",
"job",
"Jocations,",
"variations",
"in",
"social",
"settings,",
"and",
"many",
"other",
"changes",
"in",
"a",
"person’s",
"life",
"could",
"substantially",
"change",
"the",
"amount",
"of",
"background",
"ETS",
"to",
"which",
"a",
"person",
"is",
"exposed.",
"Cotinine",
"measurements",
"taken",
"at",
"one",
"time",
"may",
"not",
"represent",
"a",
"true",
"picture",
"of",
"the",
"exposure",
"ratios.",
"To",
"the",
"degree",
"that",
"the",
"sample",
"population",
"selected",
"for",
"cotinine",
"measuremnents",
"represents",
"a",
"variety",
"of",
"background",
"exposure",
"conditions,",
"however,",
"such",
"a",
"problem",
"may",
"not",
"ba",
"serious.",
"It",
"is",
"also",
"possible",
"that",
"background",
"ETS,",
"and,",
"therefore,",
"cotinine",
"levels",
"of",
"non-smokers",
"exposed",
"only",
"to",
"background",
"ETS,",
"are",
"lower",
"today",
"than",
"20",
"or",
"30",
"years",
"ago.",
"The",
"Z",
"values",
"predicted",
"from",
"today’s",
"measurements",
"are",
"likely",
"to",
"be",
"higher",
"then",
"an",
"average",
"Z",
"over",
"the",
"lifetime",
"of",
"the",
"background",
"exposure",
"ang,",
"therefore,",
"would",
"understate",
"the",
"effect",
"of",
"such",
"exposure.",
"At",
"the",
"same",
"time,",
"this",
"downward",
"trend",
"in",
"background",
"ETS",
"is",
"likely",
"to",
"continue.",
"Formal",
"and",
"informal",
"bans",
"on",
"smoking",
"in",
"public",
"areas",
"mean",
"that",
"fewer",
"and",
"fewer",
"non-smokers",
"are",
"exposed",
"to",
"much",
"ETS",
"if",
"at",
"all.",
"In",
"a",
"survey",
"of",
"workplace",
"facilities",
"by",
"the",
"International",
"Facility",
"Management",
"Association,",
"it",
"was",
"found",
"that",
"71",
"percent",
"of",
"-«",
"DRAFT",
"SUBJECT",
"TO",
"REVISION.",
"NOT",
"FOR",
"QUOTATION",
"OR",
"ATTRIBUTION.",
"@o17-038",
"1894089V",
"0%"
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2046807567_7643-21.layout.json | [
"17:26",
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[]
] |
524860047+-0116-48.layout.json | [
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"M",
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"49.",
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"for",
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"smoke.",
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"issues",
"can",
"be",
"analyzed",
"by",
"this",
"procedure",
"with",
"excellent",
"results,",
"2:30",
"pM",
"Tuespay",
"50.",
"THE",
"ANALYSIS",
"OF",
"VOLATILE",
"ALDEHYDES",
"IN",
"MAINSTREAM",
"SMOKE",
"OF",
"CIGARETTES",
"BY",
"GAS",
"CHROMATOGRAPHY,",
"Wu",
"Ming,",
"Li",
"Dong,",
"Zhao",
"Mingyue,",
"Xia",
"Qiaoling,",
"Zhengzhou",
"Tobacco",
"Research",
"Institute",
"of",
"CNTC,",
"No.88,",
"Beierqi",
"Road,",
"Zhengzhou,",
"Henan",
"450000,",
"P.R.China",
"and",
"Wang",
"Fang,",
"China",
"National",
"Tobacco",
"Quality",
"Supervision",
"&",
"Test",
"Center",
"A",
"method",
"was",
"developed",
"for",
"the",
"analysis",
"of",
"volatile",
"aldchydes",
"in",
"mainstream",
"smoke",
"of",
"cigaretles",
"by",
"gas",
"chromatography.",
"The",
"method",
"involved",
"collection",
"of",
"mainstream",
"smoke",
"of",
"cigarettes",
"and",
"reaction",
"of",
"volatile",
"aldehydes",
"with",
"2,4-dinitrophenylhydrazine",
"(2,4-DNPH)",
"in",
"HICI",
"solution.",
"The",
"resultant",
"2,4-dinitrophenyl-hydrazones",
"were",
"separated",
"and",
"finally",
"analyzed",
"by",
"GC",
"with",
"a",
"fused",
"silica",
"capillary",
"column",
"and",
"nitrogen-phosphorous",
"detection",
"(NPD).",
"The",
"method",
"repeatability",
"and",
"the",
"recoveries",
"of",
"formaldehyde,",
"acetaldehyde,",
"and",
"acrolein",
"in",
"mainstream",
"smoke",
"of",
"cigarettes",
"determiined",
"by",
"this",
"method",
"were",
"evaluated.",
"The",
"deliveries",
"of",
"formaldehydc,",
"acetaldehyde,",
"and",
"acrolcin",
"in",
"mainstream",
"smoke",
"of",
"cigarettes",
"frora",
"nine",
"commercial",
"brands",
"were",
"quantitatively",
"determined",
"by",
"internal",
"standard",
"raethod.",
"The",
"filtration",
"cfficiency",
"of",
"cigarette",
"filters",
"for",
"formaldchyde",
"in",
"mainstream",
"smoke",
"of",
"cigarettes",
"was",
"also",
"determined.",
"Twelve",
"aldehydes",
"were",
"identified",
"by",
"GC/MS",
"combined",
"with",
"standard",
"addition",
"method.",
"4",
"52486",
"0095"
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500692166_500692218-2.layout.json | [
"BY",
"ADVERTISING",
"COMMUNICATIONS",
"TEST",
"MRD#",
"79-1965",
"BACKGROUND:",
"BY",
"will",
"be",
"a",
"new",
"non-menthol",
"low",
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"and",
"is",
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"‘through",
"a",
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"imagery.",
"An",
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"communications",
"test",
"was",
"conducted",
"in",
"latter",
"July",
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"four",
"BY",
"advertising",
"executions.",
"These",
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"were",
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"and",
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"through",
"direction",
"received",
"from",
"qualitative",
"groups",
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"Jacksonville.",
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"groups,",
"two",
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"Man\"",
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"\"Contemporary",
"Kentucky",
"Mountain",
"Man\")",
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"appeared",
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"BY's",
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"product",
"and",
"user",
"imagery.",
"A",
"visual",
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"BY's",
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"are",
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"BBDO",
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"will",
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"considered",
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"OBJECTIVES",
"OF",
"RESEARCH:",
"1.",
"Determine",
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"BY",
"advertising",
"executions:",
"A.",
"On",
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"2.",
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"L",
"A.",
"The",
"main",
"idea",
"of",
"the",
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"B.",
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"BY",
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500170050.layout.json | [
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"1974.",
"Laguarda,",
"R.,",
"McCarthy,",
"C.,",
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"D.,",
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"S.,",
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"G.,",
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"G.:",
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"systemic",
"steroids.",
"Clin.",
"Res.",
"22:320,",
"Goodenough,",
"S.,",
"Simmons,",
"G.,",
"Mullane,",
"J.,",
"Feldman,",
"N.",
"and",
"Huber,",
"G.:",
"Impairment",
"of",
"pulmonary",
"antibacterial",
"defenses",
"by",
"experimental",
"stress.",
"Clin.",
"Res,",
"22:442,",
"1974.",
"Parad,",
"R.,",
"Simmons,",
"G.,",
"Feldman,",
"N.",
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"G.:",
"Impairment",
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"by",
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"Res.",
"22:425,",
"1974,",
"Goodenough,",
"S.,",
"0'Comnell,",
"D.,",
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"M.",
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"G.:",
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2076716849b_6850-1.layout.json | [
"subject",
"is",
"very",
"emotional.",
"But",
"will",
"they",
"stand",
"up",
"in",
"court?\"",
"Jim",
"Brucculeri",
"of",
"Merrill",
"Lynch",
"pointed",
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"that",
"the",
"Federal",
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"about",
"$110",
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"in",
"excise",
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"\"On",
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"you",
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"this",
"in",
"the",
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"I'm",
"not",
"so",
"sure",
"they",
"are",
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"Asked",
"about",
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"the",
"federal",
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"on",
"the",
"tobacco",
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"\"It's",
"hard",
"to",
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"valuations",
"improving",
"while",
"we",
"have",
"a",
"federal",
"lawsuit",
"hanging",
"over",
"the",
"group.”",
"One",
"Wall",
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"said",
"the",
"Federal",
"suit",
"could",
"seek",
"damages",
"ranging",
"up",
"to",
"$300",
"billion.",
"\"While",
"the",
"amount",
"of",
"damages",
"is",
"still",
"uncertain,",
"the",
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"is",
"in",
"the",
"$200",
"to",
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"the",
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"desire",
"to",
"get",
"a",
"$0.55",
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"Bill",
"Pecoriello,",
"analyst",
"at",
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"Bernstein,",
"said.",
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"that",
"with",
"a",
"decades-long",
"potential",
"trial,",
"and",
"no",
"appetite",
"in",
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"suit,",
"\"a",
"Repubfican",
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"could",
"seftle",
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"case",
"on",
"more",
"favorable",
"terms.\"",
"\"The",
"Federal",
"filing",
"is",
"a",
"good",
"thing",
"for",
"investors",
"and",
"the",
"catalyst",
"we",
"need",
"to",
"see",
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"industry",
"and",
"the",
"government",
"get",
"to",
"some",
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"Bonnie",
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"sooner",
"rather",
"than",
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"so",
"we",
"can",
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"Herzog",
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"tobacco",
"stocks",
"should",
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"court",
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"as",
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"better",
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"\"The",
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"must",
"prove",
"why",
"people",
"smoke.",
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"the",
"government",
"being",
"put",
"in",
"a",
"position",
"where",
"it",
"is",
"treating",
"these",
"sick",
"people",
"because",
"of",
"something",
"tobacco",
"companies",
"did,",
"or",
"because",
"people",
"wanted",
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"\"The",
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"can",
"allege",
"anything",
"they",
"want",
"and",
"have",
"an",
"audience",
"for",
"it,",
"but",
"thy",
"have",
"to",
"prove",
"it",
"in",
"a",
"courtroom",
"and",
"that's",
"no",
"smali",
"task,\"”",
"Cohen",
"said"
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502636262_502636273-7.layout.json | [
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2060011565.layout.json | [
"12",
"APPENDIX",
"Interview",
"only",
"One",
"Smoker",
"per",
"Household?",
"It",
"appears",
"that",
"the",
"sample",
"completion",
"rate",
"is",
"much",
"lower",
"for",
"second",
"smokers",
"selected",
"in",
"sample",
"households.",
"We",
"have",
"asked",
"for",
"tabula-",
"tions",
"to",
"verify",
"this.",
"If",
"true,",
"we",
"would",
"recommend",
"selecting",
"only",
"one",
"smoker",
"per",
"household",
"and,",
"again,",
"offsetting",
"any",
"extra",
"cost",
"by",
"shrinking",
"the",
"total",
"sample",
"size.",
"Day-of-Week",
"Weighting?",
"Given",
"weighting",
"to",
"equalize",
"weeks",
"(and",
"months),",
"we",
"would",
"also",
"equalize",
"interview",
"day-of-week",
"if",
"and",
"only",
"if",
"analysis",
"shows",
"that",
"(1)",
"key",
"results",
"vary",
"by",
"interview",
"day-of-week",
"and",
"(2)",
"the",
"day-of-",
"week",
"distribution",
"of",
"interviews",
"varies",
"between",
"survey",
"companies",
"(as",
"it",
"seems",
"to).",
"Updated",
"Census",
"Data",
"Updated",
"1990",
"Census",
"data",
"are",
"available",
"from",
"\"Market",
"Statistics\",",
"a",
"division",
"of",
"Sales",
"Management,",
"and",
"should",
"be",
"used",
"in",
"weighting",
"sample",
"adults",
"to",
"match",
"Census.",
"If",
"Smoker",
"Status",
"Uncertain",
"If",
"household",
"\"spokesperson\"",
"uncertain",
"whether",
"a",
"particular",
"adult",
"is",
"a",
"smoker,",
"record",
"as",
"\"Probably",
"Yes\"",
"or",
"\"Probably",
"No\"",
"and",
"count",
"as",
"\"Smoker\"",
"for",
"purposes",
"of",
"respondent",
"selection.",
"If",
"this",
"particular",
"person",
"is",
"selected",
"and",
"interviewed,",
"the",
"detailed",
"interview",
"should",
"clarify",
"whether",
"he/she",
"gqualifies",
"as",
"a",
"\"smoker\".",
"Otherwise,",
"count",
"this",
"adult",
"as",
"\"Smoker'\"",
"if",
"\"Probably",
"Yes\"",
"or",
"\"Non-",
"Smoker\"",
"if",
"\"Probably",
"No\",",
"for",
"the",
"recommended",
"weighting",
"of",
"each",
"smoker",
"interviewed",
"by",
"ratio",
"of",
"number",
"of",
"smokers",
"existing",
"in",
"household",
"to",
"number",
"of",
"smokers",
"interviewed.",
"CISTI00902"
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"point",
"towards",
"a",
"lower",
"price.",
"in",
"the",
"future,",
"however",
"much",
"depends",
"on",
"tue",
"performance",
"that",
"the",
"farmers",
"will",
"obtain",
"from",
"the",
"new",
"resistant",
"varieties.",
"Any",
"improvements",
"gained,",
"of",
"course,",
"will",
"be",
"passed",
"on",
"to",
"B&W.",
"5.",
"For",
"the",
"1987",
"crop",
"we",
"had",
"agreed",
"to",
"the",
"average",
"FOB",
"price",
"at",
"4,50",
"US$/KG",
"and",
"0,45",
"US$/KG",
"for",
"strips",
"and",
"stems",
"respectively.",
"6.",
"For",
"this",
"crop",
"the",
"FOB",
"strip",
"prices",
"have",
"to",
"be",
"adjusted",
"due",
"to'the",
"increase",
"of",
"23%",
"on",
"the",
"farmers",
"prices.",
"The",
"stem",
"prices",
"re",
"maing",
"the",
"same.",
"Taking",
"all",
"these",
"factors",
"into",
"consideration,",
"we",
"indicate",
"the",
"following",
"FOB",
"prices",
"for",
"1988:",
"CASES",
"PROBUCED",
"i",
"GRADE",
"US$/KG",
"1988",
"Bl",
"5,10",
"5",
"BT2",
"5,00",
"g",
"CBl",
"4,90",
"8",
"CB2",
"4,80",
"3",
"xcl",
"4,15",
"2",
"%c2",
"1,05",
"3",
"ST/Y1",
"0,145",
"6",
"'",
"35",
"%",
"204",
"KG/case",
"=",
"7.140",
"kg",
":",
"The",
"final",
"price",
"for",
"1989",
"crops",
"will",
"be",
"discussed",
"in",
"Pebruary",
"next",
"year",
"and",
"are",
"cxpected",
"to",
"be",
"in",
"line",
"with",
"BAT",
"group",
"export",
"price",
"policy.",
"682635799"
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83364727.layout.json | [
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"4m475631824m",
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2023105194.layout.json | [
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] |
508939370_508939517-125.layout.json | [
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2022161585_2022161648-30.layout.json | [
"To:",
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"PHILIP",
"MORRIS",
"U.",
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0000066843.layout.json | [
"BROWN",
"&",
"WILLIAMSON",
"TOBACCO",
"CORPORATION",
"RESEARCH,",
"DEVELOPMENT",
"&",
"ENGINEERING",
"INTERNAL",
"CORRESPONDENCE",
"TO:",
"Mr.",
"E.",
"E.",
"Kohnhorst",
"cC:",
"Mr.",
"M.",
"L.",
"Reynolds",
"Mr.",
"T.",
"F.",
"Riehl",
"Mr.",
"P.",
"R.",
"Fisher",
"Mr.",
"R.",
"H.",
"Honeycutt",
"FROM:",
"Dr.",
"R.",
"R.",
"Johnson",
"DATE:",
"December",
"5,",
"1984",
"SUBJECT:",
"ADDITIONAL",
"GENE-SPLICING",
"RESEARCH",
"AREA/316",
"At",
"your",
"request,",
"I",
"have",
"given",
"thought",
"to",
"other",
"genetic",
"engineering",
"work",
"we",
"may",
"wish",
"to",
"sponsor.",
"One",
"area",
"worth",
"consideration",
"is",
"microbial",
"production",
"of",
"tobacco",
"terpenoids",
"in",
"vats.",
"What",
"would",
"be",
"most",
"useful",
"is",
"a",
"system",
"that",
"allows",
"rapid",
"oxidation",
"of",
"these",
"terpenoids",
"to",
"produce",
"the",
"same",
"flavor",
"products",
"that",
"are",
"produced",
"by",
"slow",
"aging",
"of",
"tobacco.",
"There",
"are",
"three",
"classes",
"of",
"terpenoids",
"of",
"interest:",
"Carotenes",
"—",
"all",
"tobaccos",
"Cembranoids",
"burley",
"and",
"flue-cured",
"tobaccos",
"Labdanoids",
"oriental",
"tobaccos",
"The",
"carotenes,",
"via",
"oxidative",
"degradation,",
"appear",
"to",
"make",
"the",
"largest",
"flavor",
"contribution",
"of",
"the",
"group.",
"Moreover,",
"they",
"are",
"much",
"less",
"tobacco-specific",
"than",
"the",
"other",
"two",
"terpenoid",
"classes,",
"which",
"should",
"lead",
"to",
"more",
"rapid",
"project",
"completion.",
"R.",
"R.",
"J.",
"RRJ/sek",
"08491",
"2hYE950S9"
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530885130+-5136-4.layout.json | [
"Chinese",
"Officials",
"Plan",
"3-Week",
"Visit",
"Chinese",
"officials",
"plan",
"to",
"spend",
"three",
"weeks",
"starting",
"August",
"25\"",
"in",
"North",
"Carolina",
"and",
"Virginia’s",
"tobacco",
"ficlds,",
"warchouses",
"and",
"processing",
"plants",
"in",
"preparation",
"for",
"U.S.",
"leaf",
"exports",
"to",
"China,",
"U.S.",
"farmers",
"and",
"exporters",
"hope",
"that",
"the",
"visit",
"will",
"resull",
"in",
"purchases",
"beginning",
"as",
"early",
"as",
"December",
"1%,",
"boosting",
"quotas",
"for",
"the",
"next",
"scason.",
"U.S.",
"agriculture",
"officials",
"announce",
"next",
"ycar’s",
"quotas",
"on",
"December",
"15\",",
"Opening",
"the",
"Chinesce",
"market",
"to",
"U.S,",
"leaf",
"after",
"an",
"11-year",
"ban,",
"reporiedly",
"due",
"to",
"fears",
"of",
"blue",
"mold",
"disease,",
"could",
"mean",
"sales",
"between",
"$70",
"million",
"to",
"$140",
"million",
"per",
"year.",
"The",
"Sino-U.S.",
"tobacco",
"trade",
"agrecment",
"was",
"signed",
"in",
"July",
"2000",
"afier",
"the",
"U.S.",
"House",
"of",
"Representatives",
"voted",
"in",
"May",
"2000",
"to",
"extend",
"permancnt",
"trade",
"relations",
"(Richmond",
"Times-",
"Dispatch",
"8/22).",
"China:",
"Seized",
"&",
"Discounted",
"Cigarettes",
"Sell",
"Briskly",
"Sales",
"are",
"brisk",
"at",
"shops",
"in",
"Beijing",
"established",
"to",
"scll",
"cigareltes",
"seized",
"by",
"customs",
"officials,",
"Popular",
"brands",
"include",
"Hilton",
"that",
"is",
"selling",
"for",
"50",
"yuan",
"(US$",
"6.00)",
"a",
"carton,",
"30",
"yuan",
"(US$",
"3.62)",
"less",
"than",
"the",
"market",
"value.",
"555",
"sells",
"at",
"a",
"discounted",
"price",
"of",
"90",
"yuan",
"(US$",
"10.90)",
"a",
"carlon.",
"Other",
"available",
"brands",
"include",
"Kent",
"and",
"More",
"(TobaccoChina",
"Online",
"8/22).",
"China:",
"Oriental",
"Cigarette",
"Center",
"Planned",
"The",
"Lli",
"prefecture",
"will",
"launch",
"an",
"oriental",
"cigaretie",
"production",
"center",
"in",
"the",
"Xinjiang",
"Uygur",
"Autonomous",
"Region",
"with",
"the",
"support",
"of",
"the",
"State",
"Tobacco",
"Monopoly",
"Administration.",
"The",
"administration",
"will",
"invest",
"10",
"million",
"yuan",
"(US$",
"1.21",
"mn)",
"in",
"the",
"first",
"phase",
"to",
"build",
"three",
"or",
"four",
"oricntal",
"cigaretic",
"development",
"centers",
"in",
"three",
"Lo",
"four",
"years",
"(TobaccoChina",
"Online",
"8/22).",
"innovative,",
"information",
"technology,",
"and",
"managerial",
"measures",
"Lo",
"improve",
"lcaf",
"quality.",
"It",
"also",
"resolved",
"to",
"take",
"steps",
"to",
"integrate",
"industry",
"with",
"agriculture,",
"encourage",
"research",
"and",
"develop",
"an",
"agricultural",
"information",
"system",
"(TobaccoChina",
"Online",
"8/22).",
"Japan:",
"Kanebo",
"Gum",
"To",
"Replace",
"Cigarettes",
"Kanebo",
"Foods",
"has",
"introduced",
"“Kinen",
"Scki",
"Gum,”",
"a",
"new",
"chewing",
"gum",
"that",
"reportedly",
"can",
"be",
"consumed",
"as",
"a",
"replacement",
"for",
"smoking",
"cigarcttcs.",
"The",
"gum",
"sells",
"for",
"¥200",
"(US$",
"1.80)",
"for",
"five",
"picces.",
"The",
"nicotine-free",
"gum",
"supposedly",
"tastes",
"like",
"menthol",
"cigarettes",
"{New",
"Food",
"Products",
"6/00].",
"Singapore:",
"Smoking",
"Control",
"Chair",
"Opposed",
"To",
"Banning",
"Cigarettes",
"Smoking",
"Control",
"Committee",
"chairman",
"Alex",
"Chan",
"does",
"not",
"support",
"banning",
"cigarettes",
"in",
"Singapore",
"because",
"he",
"belicves",
"the",
"measure",
"would",
"drive",
"the",
"business",
"underground",
"instead",
"of",
"eliminating",
"it.",
"Comparing",
"cigarettes",
"with",
"narcotic",
"drugs,",
"Chan",
"said,",
"“The",
"banning",
"of",
"hard",
"illicit",
"drugs",
"and",
"trendy",
"designer",
"drugs,",
"such",
"as",
"Ecstasy",
"for",
"example,",
"and",
"the",
"imposition",
"of",
"the",
"death",
"penalty",
"for",
"trafficking",
"have",
"not",
"stopped",
"narcotic",
"usage",
"totally",
"in",
"Singapore.”",
"In",
"1999",
"smokers",
"in",
"Singapore",
"spent",
"S$",
"871",
"million",
"(US$",
"500",
"mn)",
"consuming",
"3.23",
"billion",
"cigarettes,",
"according",
"to",
"excise",
"duty",
"collections",
"on",
"tobacco",
"products.",
"The",
"total",
"spending",
"on",
"smoking",
"in",
"the",
"country",
"during",
"the",
"past",
"six",
"years",
"would",
"amount",
"to",
"S$",
"5",
"billion",
"(US$",
"2.91",
"bn)",
"(Straits",
"Times",
"8/20).",
"Hong",
"Kong:",
"Yunnan",
"To",
"Diversify",
"Tobacco",
"products",
"exporter",
"Yunnan",
"Enterpriscs",
"Holdings",
"will",
"diversify",
"into",
"biomedical",
"and",
"information",
"technology",
"areas",
"to",
"offset",
"its",
"falling",
"tobacco",
"exports,",
"according",
"to",
"the",
"company",
"chairman",
"Zi",
"Guorui.",
"He",
"added",
"that",
"Yunnan",
"plans",
"to",
"increase",
"its",
"stake",
"in",
"Shenzhen",
"Xinpeng",
"Biotechnology",
"Engineering",
"Investment",
"to",
"52",
"percent",
"from",
"the",
"current",
"48",
"percent",
"after",
"the",
"biotech",
"company",
"successfully",
"launches",
"high-growth",
"technology",
"companies",
"on",
"the",
"mainland.",
"The",
"company",
"reported",
"a",
"net",
"profit",
"of",
"HK$",
"757,699",
"(US$",
"97,100)",
"for",
"fiscal",
"1999-2000",
"ended",
"March",
"31,",
"2000,",
"compared",
"to",
"a",
"loss",
"of",
"HK$",
"89,626",
"(US$",
"11,490)",
"reported",
"during",
"the",
"previous",
"year,",
"Turnover",
"declined",
"from",
"HK$",
"44",
"(Zhongxin",
"Network",
"8/22),",
"million",
"(US$",
"5.6",
"mn)",
"last",
"year",
"to",
"HK$",
"10.63",
"million",
"&)",
"(US$",
"1.4",
"mn)",
"this",
"year",
"due",
"10",
"sluggish",
"tobacco",
"2",
"China:",
"Hongta",
"Group",
"To",
"Improve",
"Leaf",
"exports",
"(South",
"China",
"Morning",
"Post",
"8/22).",
"®",
"China;",
"Year’s",
"Tobacco",
"Scene",
"Encouraging",
"Keeping",
"pace",
"with",
"the",
"recovery",
"of",
"the",
"Chinese",
"economy",
"in",
"the",
"first",
"half",
"of",
"2000,",
"the",
"tobacco",
"industry",
"is",
"expected",
"to",
"contribute",
"more",
"than",
"10",
"billion",
"yuan",
"(US$",
"1.21",
"bn)",
"in",
"annual",
"taxes.",
"Zhongxin",
"Network",
"reported",
"on",
"August",
"22™",
"that",
"the",
"overall",
"production",
"scenario",
"in",
"China",
"was",
"encouraging",
"in",
"the",
"first",
"half",
"of",
"the",
"year",
"with",
"the",
"quick",
"arrest",
"of",
"a",
"slide",
"in",
"cigaretle",
"production",
"At",
"a",
"conference",
"on",
"development",
"of",
"tobacco",
"leaf",
"and",
"A",
"ecological",
"resources",
"in",
"Yuxi",
"City",
"on",
"August",
"3%,",
"the",
"w",
"Hongta",
"Group",
"resolved",
"to",
"take",
"a",
"number",
"of",
"»",
"WAQ0-34",
"T",
"P.0.",
"Box",
"8019;",
"Princeton,",
"N.J.",
"08543;",
"609-275-4900;",
"609-275-8379",
"(fax);",
"[email protected]",
"5",
"RJR0000001145023422",
".",
"70060",
"0030767"
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2046807567_7643-63.layout.json | [
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145,
185,
142
],
[
186,
185,
144,
145,
150,
187,
143
],
[
151,
144,
150,
152
],
[
145
],
[
146
],
[
147
],
[
148
],
[
149
],
[],
[
187,
152
],
[
177,
152
],
[
187,
188,
153,
177
],
[
189,
154,
177
],
[
155,
176,
177,
190,
189
],
[
156,
191,
176,
175,
190
],
[
192,
157,
174,
173,
175
],
[
193,
192,
158,
173
],
[
159,
194,
171,
172,
173,
193
],
[
160,
195,
194,
171
],
[
196,
198,
161,
195,
169,
170,
171
],
[
198,
162,
169
],
[
199,
198,
168,
163,
167
],
[
200,
199,
201,
167
],
[
203,
165
],
[
202,
166
],
[
201,
167
],
[
168
],
[
169
],
[
170
],
[
171
],
[
172
],
[
173
],
[
174
],
[
175
],
[
176
],
[
177
],
[],
[
271,
269,
219,
179,
218
],
[
180,
218
],
[
181,
217,
218
],
[
216,
217,
182
],
[
183,
215
],
[
184,
214,
215
],
[
185,
213,
214
],
[
212,
186,
213
],
[
211,
187
],
[
210,
211,
188
],
[
209,
189,
210
],
[
208,
209,
190,
207
],
[
191,
207
],
[
206,
192,
207
],
[
205,
206,
193
],
[
204,
194,
205
],
[
224,
195,
204
],
[
224,
196,
197,
223,
222
],
[
198,
197
],
[
198,
222
],
[
199,
222,
221
],
[
221,
220,
200
],
[
201,
228,
220
],
[
202,
227,
226,
228
],
[
226,
203
],
[
225,
226
],
[
224,
245,
205,
244
],
[
206,
243
],
[
242,
243,
207,
241
],
[
241,
208
],
[
209,
241,
239,
240
],
[
239,
238,
210
],
[
211,
238
],
[
212,
237
],
[
213,
236,
237
],
[
214,
236,
235
],
[
215,
234,
235
],
[
216,
234,
233
],
[
217,
232,
233
],
[
231,
230,
218
],
[
219,
229,
230
],
[
229,
269
],
[
221,
228
],
[
248,
222
],
[
248,
247,
246,
223
],
[
224,
246
],
[
245,
246
],
[
251,
226
],
[
251,
250,
227
],
[
250,
249,
228
],
[
249
],
[
230,
272,
269
],
[
276,
272,
231,
278
],
[
278,
232
],
[
278,
281,
233,
285
],
[
234,
285
],
[
235,
289,
285
],
[
236,
292,
297,
289
],
[
297,
237
],
[
297,
238,
301
],
[
239,
306,
301
],
[
240,
306,
311
],
[
241,
317
],
[
322,
317,
242,
325
],
[
243,
325
],
[
331,
244
],
[
331,
334,
245
],
[
246,
339,
334
],
[
247,
345,
343,
339
],
[
345,
248
],
[
345,
352,
355
],
[
250,
363,
360
],
[
251,
365,
363,
367
],
[
367
],
[
258,
257,
253
],
[
254,
258,
260
],
[
255,
260
],
[
256,
261,
260
],
[
261
],
[
265,
259,
258
],
[
259
],
[
265,
260
],
[
261,
266
],
[
373,
266
],
[
270,
263
],
[
264,
268,
267
],
[
265,
268
],
[
272,
266
],
[
273,
274,
275,
272
],
[
268,
269,
271
],
[
269
],
[
271
],
[
271
],
[],
[
276,
273
],
[
274,
277,
276
],
[
275,
277
],
[
280
],
[
278,
277
],
[
278,
279
],
[
281,
279
],
[
282,
281,
280
],
[
283,
282
],
[
282,
286,
287,
285
],
[
283,
288,
290
],
[
291,
284
],
[
376,
377,
309,
291
],
[
289,
286
],
[
289,
287
],
[
289,
288
],
[
290
],
[
292,
293,
290
],
[
291,
294,
293
],
[
295,
309,
296
],
[
297,
293,
298
],
[
298,
294,
299
],
[
295,
300,
299
],
[
296,
300
],
[
309
],
[
298,
301
],
[
302,
303,
299,
301
],
[
303,
300
],
[
303,
304
],
[
306,
302
],
[
303,
306
],
[
307,
306,
304
],
[
305,
307,
308
],
[
308
],
[
311,
307,
313,
312
],
[
308,
313
],
[
315,
314,
313
],
[
310
],
[
378,
379
],
[
312,
317
],
[
313,
318,
317
],
[
319,
318,
314,
320
],
[
315,
321,
320
],
[
316,
321
],
[
384,
328,
329,
383
],
[
322,
318
],
[
319,
323,
322
],
[
324,
320,
323
],
[
324,
321
],
[],
[
325,
323
],
[
324,
326,
325
],
[
326
],
[
332,
326,
331
],
[
332,
333,
327
],
[
338,
328
],
[
338,
329
],
[
330
],
[
387,
386
],
[
334,
332
],
[
335,
333,
334
],
[
336,
337,
335
],
[
335,
340,
339
],
[
336,
340,
341
],
[
342,
337,
341
],
[
338,
342
],
[],
[
340,
343,
344
],
[
341,
344
],
[
342,
349
],
[
349,
350
],
[
345,
346,
344
],
[
348,
347,
346
],
[
352,
346
],
[
352,
347
],
[
348,
352
],
[
353,
349,
352
],
[
353,
350
],
[
351,
354
],
[
371
],
[
355,
356,
353,
357
],
[
354,
359,
357,
358
],
[
371,
359
],
[
360,
356
],
[
357,
360
],
[
360,
361,
358
],
[
359,
361
],
[
361,
362
],
[
361,
363,
364
],
[
362,
364
],
[
396,
371
],
[
365,
364
],
[
366,
365
],
[
367,
368,
366
],
[
370,
369,
368
],
[
368
],
[
369
],
[
370
],
[
398
],
[
372
],
[
393,
392,
394
],
[
401,
374
],
[
375,
401,
402
],
[
376
],
[
377
],
[
378
],
[
408,
407,
379
],
[
407,
380
],
[
381,
406,
407
],
[
382,
405,
406
],
[
404,
383
],
[
404,
403,
384
],
[
411,
385,
403
],
[
411,
417,
386
],
[
417,
416,
387
],
[
388,
415,
416
],
[
415,
414,
389,
413
],
[
390,
413
],
[
391,
413,
426
],
[
392,
425,
424,
426
],
[
424,
393
],
[
423,
394,
424
],
[
395,
423,
422,
431
],
[
431,
396,
430
],
[
430,
397
],
[
398,
429
],
[
428,
429
],
[
400,
401
],
[
434,
401
],
[
434,
402
],
[
434,
435,
408,
436
],
[
404,
411,
412,
444
],
[
409,
405,
444,
443
],
[
409,
406
],
[
407,
440,
441,
409
],
[
410,
408,
440
],
[
410
],
[
441,
442
],
[
438,
439
],
[
417,
412
],
[
445,
444,
419
],
[
426,
414,
418
],
[
415,
418
],
[
416,
421
],
[
417,
421,
420
],
[
419,
420
],
[
450,
449,
421
],
[
446,
445,
420
],
[
447,
446,
421
],
[
448
],
[
455,
423,
431,
456
],
[
454,
424
],
[
425,
427
],
[
426,
452,
451
],
[
451
],
[
454,
453,
452
],
[
460,
459,
429
],
[
459,
430
],
[
432,
431
],
[
432,
456
],
[
458,
456
],
[
462,
461,
434
],
[
435,
462,
464
],
[
436,
464,
465
],
[
471,
437,
465
],
[
438,
470,
471
],
[
470,
469,
439
],
[
467,
468,
440,
469
],
[
467,
441
],
[
467,
466,
442
],
[
488,
443,
466
],
[
487,
488,
444,
486
],
[
486,
445
],
[
446,
485,
486
],
[
447,
485,
484
],
[
448,
484,
483
],
[
449,
482
],
[
481,
450
],
[
481,
480,
451
],
[
479,
452,
480
],
[
478,
477,
453
],
[
477,
454
],
[
455,
476
],
[
475,
457,
456
],
[
457,
458
],
[
474,
475,
458
],
[
459,
473,
474
],
[
460,
472,
473
],
[
489
],
[
502,
463,
462
],
[
463,
464
],
[
502,
464
],
[
490,
465
],
[
490,
471
],
[
467,
496,
488
],
[
495,
468,
496
],
[
495,
494,
469
],
[
470,
493,
492
],
[
471,
492
],
[
492,
491
],
[
473,
489
],
[
474
],
[
475
],
[
476
],
[
477
],
[
478
],
[
479
],
[
480
],
[
481
],
[
482
],
[
483
],
[
501,
484
],
[
485,
501
],
[
500,
486
],
[
487,
499,
498,
500
],
[
488,
498
],
[
496,
497,
498
],
[],
[
491
],
[
492
],
[
493
],
[
494
],
[
495
],
[
496
],
[
497
],
[
498
],
[
499
],
[
500
],
[
501
],
[],
[]
] |
Subsets and Splits